04-02-2016 дата публикации
Номер: US20160031816A1
Принадлежит:
The present invention provides compounds of Formula (I): 1. A compound of Formula (I):{'sup': 4', '16', '5', '16, 'x and y can be both a single bond; when x is a double bond, then y is a single bond and Rand Rare absent; when y is a double bond, then x is a single bond and Rand Rare absent;'}{'sup': 1', 'b', 'g', 'e', 'b', 'g', 'a, 'sub': 4-18', '2-8', '2', '1-8', '2', '2-8', '2', 'm', '3-10', '2', 'm', '1-12, 'Ris independently selected from the group consisting of: —CONH(Calkyl), —CONHChaloalkyl, —CONH(CH)Ph, —CONHCHCOCalkyl, —(CH)—(Ccarbocycle substituted with 0-2 Rand 0-2 R), —(CH)-(5- to 6-membered heteroaryl comprising: carbon atoms and 1-4 heteroatoms selected from N, NR, O and S; wherein said heteroaryl is substituted with 0-1 Rand 0-2 R), and a Chydrocarbon chain substituted with 0-3 R; wherein said hydrocarbon chain may be straight or branched, saturated or unsaturated;'}{'sup': '2', 'sub': 1-4', '3-4', '1-4, 'Ris independently selected from the group consisting of: Calkyl, Ccycloalkyl, and Chaloalkyl;'}{'sup': '3', 'sub': '1-4', 'Ris independently selected from the group consisting of: H, F, Cl, Calkyl and CN;'}{'sup': 4', '5, 'sub': '1-4', 'Rand Rare independently selected from the group consisting of: H, F, Cl, and Calkyl;'}{'sup': 3', '4, 'when x is a single bond, Rand Rmay be combined with the carbon atom to which they are attached to form a 3- to 6-membered carbocycle;'}{'sup': 6', 'c', 'c', 'j', 'j', 'j', 'j', 'j', 'f', 'j, 'sub': 1-4', '2', '2', 'n', 't', '2', 'm', '2', '1-6', '1', '2', '2', '2', '2, 'Ris independently selected from the group consisting of: H, halo, Calkyl, CN, NO, R, —(CH)—(X)—(CH)R, NH, —CONH(Calkyl), —NHCOXSOR, —NHCOCHPO(OEt), —NHCOCOR, —NHCOCH(OH)R, —NHCOCHCOR, —NHCONHR, and —OCONRR;'}X is independently selected from the group consisting of: O, S, NH, CONH, and NHCO;{'sub': 1', '1-4', '1-4', '3-4, 'Xis independently Chydrocarbon chain optionally substituted with Calkyl or Ccycloalkyl;'}{'sup': 5', '6, 'when y is a single bond, ...
Подробнее