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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 5. Отображено 5.
10-06-2008 дата публикации

Scintillation proximity assay method of measuring acetyl CoA carboxylase enzyme activity

Номер: US0007384757B2
Автор: Ramakrishna Seethala, Dong Cheng, SEETHALA RAMAKRISHNA, CHENG DONG
Принадлежит: Bristol-Myers Squibb Company, SQUIBB BRISTOL MYERS CO, BRISTOL-MYERS SQUIBB COMPANY

The present invention relates generally to enzyme assays and more particularly to a rapid, sensitive, reliable and robust homogeneous assay for acetyl CoA carboxylase activity comprising a coupled enzyme assay in a scintillation proximity format suitable for high-throughput screening. In one aspect, the assay couples ACC and FAS and the product, palmitic acid is then detected by scintillation counting. The invention also relates to the identification of modulators of ACC activity.

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Номер записи: 1
06-10-2005 дата публикации

Scintillation proximity assay method of measuring acetyl CoA carboxylase enzyme activity

Номер: US20050221410A1
Автор: Ramakrishna Seethala, Dong Cheng
Принадлежит: Bristol Myers Squibb Co

The present invention relates generally to enzyme assays and more particularly to a rapid, sensitive, reliable and robust homogeneous assay for acetyl CoA carboxylase activity comprising a coupled enzyme assay in a scintillation proximity format suitable for high-throughput screening. In one aspect, the assay couples ACC and FAS and the product, palmitic acid is then detected by scintillation counting. The invention also relates to the identification of modulators of ACC activity.

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Номер записи: 2
10-04-2008 дата публикации

GLUCOKINASE ACTIVITY ASSAYS FOR MEASURING KINETIC AND ACTIVATION PARAMETERS

Номер: US20080085528A1
Автор: Jovita Marcinkeviciene, Kevin O'Malley, Mark Kirby, Aiying Wang, Lisa Kopcho, Ramakrishna Seethala
Принадлежит: Bristol-Myers Squibb Company

The subject matter disclosed and claimed herein relates to novel in vitro assays for measuring glucokinase activity and use of these assays for identifying modulators of glucokinase.

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Номер записи: 3
09-12-2010 дата публикации

FLUORESCENCE POLARIZATION BINDING ASSAY FOR CHARACTERIZING GLUCOKINASE LIGANDS

Номер: US20100311072A1
Автор: Ramakrishna Seethala, Jessica Leihwa Dong, Kevin M. O'Malley
Принадлежит: Bristol-Myers Squibb Company

The subject matter disclosed and claimed herein concerns measuring the binding affinity of glucokinase (“GK”) using a fluorescence polarization (“FP”) assay. The FP method includes use of modified GK ligands bound to a fluorescent label. Binding affinity is determined by measuring displacement of fluorescent ligand by the known or suspected GK ligands. The subject matter disclosed and claimed herein provides a robust high-throughput FP assay for the determination of binding affinity of ligands to glucokinase. The FP binding assay displayed both glucose and nucleotide dependence, and a useful dynamic range. The binding IC50 data correlated well with GK activation EC50 data.

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Номер записи: 4
08-12-1996 дата публикации

Dihydropyridine npy antagonists: piperazine derivatives

Номер: CA2178413A1
Автор: Charles P. Sloan, Graham Johnson, Graham S. Poindexter, Ivo Monkovic, Karen Leboulluec, Marc Bruce, Michael Kozlowski, Ramakrishna Seethala
Принадлежит: Bristol Myers Squibb Co

A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of piperazine and homopiperazine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I).

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Номер записи: 5