24-01-2019 дата публикации
Номер: US20190022049A1
Принадлежит:
Disclosed are hydroquinone compounds, preparation methods therefor, and uses thereof in anti-tumor or immunomodulation. The structural formula of the hydroquinone compounds are shown by formula I, 2. The compounds claim 1 , the salts claim 1 , the hydrates or the solvates according to claim 1 , wherein: the substituent groups in R are halogen claim 1 , amino group claim 1 , nitro group claim 1 , ester group claim 1 , carbonyl group claim 1 , amino acid derivatives claim 1 , natural flavone claim 1 , natural alkaloid claim 1 , polyethylene glycol claim 1 , polyglutamic acid or polysaccharide.3. The compounds claim 1 , the salts claim 1 , the hydrates or the solvates according to claim 1 , wherein:{'sub': '2', 'when X is C═O, Y is NH; when X is CH, Y is O; or'}{'sub': '2', 'X is C═O or CH, Y is absent.'}4. The compounds claim 3 , the salts claim 3 , the hydrates or the solvates according to claim 3 , wherein: the compound is:1) (2-tert-butyl-4-methoxyphenol) (N-benzyl)carbamate,2) (2-tert-butyl-4-methoxyphenol) (N-n-butyl)carbamate,3) (2-tert-butyl-4-methoxyphenol) (N-isopropyl)carbamate,4) (2-tert-butyl-4-methoxyphenol) (N-cyclohexyl)carbamate,5) (2-tert-butyl-4-methoxyphenol) (N-phenethyl)carbamate,6) pivaloyl(2-tert-butyl-4-methoxyphenol-oxyl) methyl ester,7) 2-tert-butyl-4-methoxyphenol benzoate,8) 2-tert-butyl-4-methoxyphenol acetate,9) 2-tert-butyl-4-methoxyphenol nicotinate,10) 2-tert-butyl-4-methoxyphenol isonicotinate,11) 2-tert-butyl-4-methoxyphenol cyclohexenecarboxylate,12) 2-tert-butyl-4-methoxyphenol propionate,13) 2-tert-butyl-4-methoxyphenol acrylate,14) (2-tert-butyl-4-methoxyphenol) 3,4-dimethoxyphenylacetate,15) 2-tert-butyl-4-methoxyphenol butynoate,16) bis(2-tert-butyl-4-methoxyphenol) 2,2′-biphenyldicarboxylate,17) (2-tert-butyl-4-methoxyphenol) 2-chloro-5-trifluoromethylbenzoate,18) (2-tert-butyl-4-methoxyphenol) 3-fluorophenylacetate,19) (2-tert-butyl-4-methoxyphenol) (1H-indole-3-yl)acetate,20) (2-tert-butyl-4-methoxyphenol) 3-(4-fluorophenyl ...
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