18-07-2013 дата публикации
Номер: US20130184294A1
The present invention relates to compounds of Formula I as described herein or a pharmaceutically acceptable salt thereof, pharmaceutical composition comprising a compound of Formula I or a pharmaceutically acceptable salt thereof and methods of treating a disease, disorder, or condition of the central nervous system, including bipolar disorder, depressive disorders, anxiety disorders, cognitive disorders, pain disorders, urogenital disorders, and epilepsy, among the other diseases, disorders or conditions discussed herein as mono-therapy or in combination with another active pharmaceutical ingredient. 2. The compound of claim 1 , wherein:{'sup': '1', 'sub': '5-6', 'Ris Calkyl;'}{'sup': 2', '4', '5', '4', '5, 'sub': 3-6', '3-6', '1-3', '3-6, 'Ris NRR, wherein one of Ror Ris H and the other is Calkyl, Ccycloalkyl, or —Calkyl-Ccycloalkyl;'}{'sup': '3', 'Ris halogen, alkyl, or alkoxy, wherein any alkyl may be substituted with one or more halogen atoms;'}{'sub': 2', '2, '—X—Y— is ═CH—CH═ or —CH—CH—; or a pharmaceutically acceptable salt thereof.'}3. The compound of claim 1 , wherein:{'sup': '1', 'sub': 2', '3', '3, 'Ris —CHC(CH);'}{'sup': '3', 'Ris chloro, methyl, trifluoromethyl or 1,1-difluoroethoxy;'}{'sup': 4', '5, 'Ris H and Ris isopropyl, isobutyl, 1-cyclopropylethyl, cyclobutyl or cyclopentyl;'}{'sub': 2', '2, '—X—Y— is ═CH—CH═ or —CH—CH—; or a pharmaceutically acceptable salt thereof.'}4. The compound of claim 1 , wherein:{'sup': '1', 'sub': '5-6', 'Ris Calkyl;'}{'sup': '2', 'sub': '3-6', 'Ris Ccycloalkyl;'}{'sup': '3', 'Ris halogen, or alkyl, wherein alkyl may be substituted with one or more halogen atoms;'}{'sub': 2', '2, '—X—Y— is ═CH—CH═ or —CH—CH—; or a pharmaceutically acceptable salt thereof.'}5. The compound of claim 1 ,{'sup': '1', 'sub': 2', '3', '3, 'Ris —CHC(CH);'}{'sup': '2', 'Ris cyclopropyl;'}{'sup': '3', 'Ris chloro, methyl, trifluoromethyl or 1,1-difluoroethoxy;'}{'sub': 2', '2, '—X—Y— is ═CH—CH═ or —CH—CH—; or a pharmaceutically acceptable salt ...
Подробнее