Class ii human histone deacetylases, and uses related thereto

The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors.

Lubricating Composition Containing a Compound Derived from a Hydroxy-carboxylic Acid

The invention relates to a lubricating composition comprising (a) a compound derived from a hydroxy-carboxylic acid, and (b) an oil of lubricating viscosity. The invention further provides for the use of the lubricating composition for lubricating a limited slip differential.

Dehydrogenation Process

In a dehydrogenation process a hydrocarbon stream comprising at least one non-aromatic six-membered ring compound and at least one five-membered ring compound is contacted with a dehydrogenation catalyst produced by a method comprising treating the support with a liquid composition comprising the dehydrogenation component or a precursor thereof and at least one organic dispersant selected from an amino alcohol and an amino acid. The contacting is conducted under conditions effective to convert at least a portion of the at least one non-aromatic six-membered ring compound in the hydrocarbon stream to benzene and to convert at least a portion of the at least one five-membered ring compound in the hydrocarbon stream to paraffins. 1. A dehydrogenation process comprising:(a) providing a hydrocarbon stream comprising at least one non-aromatic six-membered ring compound and at least one five-membered ring compound; and(b) producing a dehydrogenation reaction product stream comprising the step of contacting at least a portion of the hydrocarbon stream with a dehydrogenation catalyst comprising a support and a metal component under conditions effective to convert at least a portion of the at least one non-aromatic six-membered ring compound to benzene and to convert at least a portion of the at least one five-membered ring compound to at least one paraffin,wherein the dehydrogenation catalyst is produced by a method comprising treating the support with a liquid composition comprising the metal component or a precursor thereof and at least one organic dispersant selected from an amino alcohol and an amino acid.2. The process of claim 1 , wherein the dehydrogenation catalyst has an alpha value from about 0 to about 20.3. The process of claim 1 , wherein the dehydrogenation catalyst has an alpha value from about 0 to about 5.4. The process of claim 1 , wherein the dehydrogenation catalyst has an alpha value from about 0 to about 1.5. The process of claim 1 , wherein the ...

Dehydrogenation Process

In a process for the dehydrogenation of dehydrogenatable hydrocarbons, a feed comprising dehydrogenatable hydrocarbons is contacted with a catalyst comprising a support and a dehydrogenation component under dehydrogenation conditions effective to convert at least a portion of the dehydrogenatable hydrocarbons in the feed. The catalyst is produced by a method comprising treating the support with a liquid composition comprising the dehydrogenation component or a precursor thereof and at least one organic dispersant selected from an amino alcohol and an amino acid. 1. A process for the dehydrogenation of at least one dehydrogenatable hydrocarbon , the process comprising (i) contacting a feed comprising the at least one dehydrogenatable hydrocarbon with a catalyst comprising a support and a dehydrogenation component under dehydrogenation conditions effective to convert at least a portion of the dehydrogenatable hydrocarbon in the feed , wherein the catalyst is produced by a method comprising treating the support with a liquid composition comprising the dehydrogenation component or a precursor thereof and at least one organic dispersant selected from an amino alcohol and an amino acid.2. The process of claim 1 , wherein the organic dispersant is present in the liquid composition in an amount between about 1 wt % and about 20 wt % of the composition.3. The process of claim 1 , wherein the support is at least one material selected from silica claim 1 , a silicate claim 1 , an aluminosilicate claim 1 , carbon claim 1 , and carbon nanotubes and preferably comprises silica.4. The process of claim 1 , wherein the dehydrogenation component comprises at least one metal component selected from Groups 6 to 10 of the Periodic Table of Elements.5. The process of claim 1 , wherein the dehydrogenation component consists of one metal component selected from Group 10 of the Periodic Table of Elements.6. The process of claim 1 , wherein the dehydrogenation component consists of one metal ...

System for assessing a fit of a femoral implant

A system for virtually planning a size and position of a prosthetic implant for a bone on a patient includes a database containing pre-defined form factor information for a plurality of different implants and a circuit for obtaining surface shape information of the bone. The system further includes a circuit for defining baseline location parameters for an implant location in relation to a virtual representation of the bone based on the surface shape information and a circuit for assessing a fit calculation of each implant in relation to the virtual representation of the bone based on the form factor in formation and a plurality of fit factors at each of a plurality of incremental positions in relation to the bone. Still further, the system includes a circuit for selecting a best fit implant size and position from all of the fit calculations.

Lubricating Composition

The invention relates to a lubricating composition containing (a) an oil of lubricating viscosity, and (b) an oil soluble compound with a >N—R—N< group, wherein R may be a hydrocarbylene group. The invention further provides for the use of the lubricating composition for lubricating a limited slip differential.

Hydrocarbon hydroprocessing using bulk catalyst composition

The invention relates to a method for hydroprocessing hydrocarbon feedstocks, said process comprising contacting a hydrocarbon feedstock under hydroprocessing conditions with a bulk catalyst composition comprising bulk metal particles that comprise at least one Group VIII non-noble metal, at least one Group VIB metal and nanoparticles. The bulk metal catalyst composition comprises bulk metal particles that may be prepared by a manufacturing process comprising the steps of combining in a reaction mixture (i) dispersible nanoparticles having a dimension of less than about 1 μm upon being dispersed in a liquid, (ii) at least one Group VIII non-noble metal compound, (iii) at least one Group VIB metal compound, and (iv) a protic liquid; and reacting the at least one Group VIII non-noble metal compound and the at least one Group VIB metal in the presence of the nanoparticles. 1. A method for hydroprocessing hydrocarbon feedstocks , said method comprising contacting a hydrocarbon feedstock under hydroprocessing conditions with a bulk catalyst composition comprising bulk metal particles , wherein said bulk metal particles compriseat least one Group VIII non-noble metal and at least one Group VIB metal, said metals being in the form of oxides, sulfides, or a combination of oxides and sulfides, andnanoparticles having a dimension of less than 1 μm, said nanoparticles being different in composition from said Group VIII non-noble metal and Group VIB metal oxides, sulfides, or combination of oxides and sulfides.2. The method of claim 1 , whereinthe combined weight of Group VIII non-noble metal and Group VIB metal in said bulk metal particles, calculated as weight of metal oxides relative to the total weight of bulk metal particles, represents from 50 wt. % to 99.5 wt. % of the total weight of the bulk metal particles; and,the weight of nanoparticles in said bulk metal particles represents from 0.5 wt. % to 15 wt. % relative to the total weight of the bulk metal particles.3. The ...

Stabilized Blends Containing Friction Modifiers

The present invention relates to functional fluid compositions containing friction modifiers, and specifically stable compositions containing friction modifiers with limited solubility in and/or limited compatibility with the functional fluids with which they are used. In particular the present invention deals with functional fluids used in internal combustion engines, such as engine oils, and friction modifiers that contain one or more amide functional groups, where the friction modifier is present in the functional fluid composition at levels that would otherwise cause the composition to be unstable and/or hazy.

PROCESSING OF HEAVY HYDROCARBON FEEDS

Systems and methods are provided for hydroconversion of a heavy oil feed under slurry hydroprocessing conditions and/or solvent assisted hydroprocessing conditions. The systems and methods for slurry hydroconversion can include the use of a configuration that can allow for improved separation of catalyst particles from the slurry hydroprocessing effluent. In addition to allowing for improved catalyst recycle, an amount of fines in the slurry hydroconversion effluent can be reduced or minimized. This can facilitate further processing or handling of any “pitch” generated during the slurry hydroconversion. The systems and methods for solvent assisted hydroprocessing can include processing of a heavy oil feed in conjunction with a high solvency dispersive power crude. 1. A process for producing a hydroprocessed product , comprising:exposing a feedstock to a catalyst under effective slurry hydroconversion conditions to form a slurry hydroprocessing effluent, the effective slurry hydroconversion conditions being effective for conversion of at least about 90 wt % of the feedstock relative to a conversion temperature, the catalyst comprising catalyst particles having a particle size of at least about 2 μm; andseparating at least about 95 wt % of the catalyst particles having a particle size of at least about 2 μm from the slurry hydroprocessing effluent using a catalyst recovery system comprising one or more drum separators and a cross-flow filter.2. The process of claim 1 , wherein the feedstock has a T95 distillation point of about 600° C. or less.3. The process of claim 1 , wherein the feedstock has a 10% distillation point of at least about 900° F. (˜482° C.) claim 1 , a Conradson carbon residue of at least about 27.5 wt % claim 1 , or a combination thereof.4. The process of claim 1 , wherein the one or more drum separators comprise cyclone separators.5. The process of claim 1 , further comprising exposing the feedstock to a demetallization catalyst under slurry ...

Dry insertion and one-point in vivo calibration of an optical analyte sensor

Disclosed are embodiments that relate to the deployment of a glucose sensor comprising an optical fiber into a physiological fluid, wherein the optical fiber has disposed along a distal region thereof a chemical indicator system comprising a fluorophore and a glucose binding moiety immobilized within a hydrogel, wherein the components of the chemical indicator system are in a dry state before deployment. Also disclosed is a one-point in vivo calibration of the chemical indicator system based on an independently measured glucose concentration.

Intraoperative dynamic trialing

A dynamic trialing method generally allows a surgeon to perform a preliminary bone resection on the distal femur according to a curved or planar resection profile. With the curved resection profile, the distal-posterior femoral condyles may act as a femoral trial component after the preliminary bone resection. This may eliminate the need for a separate femoral trial component, reducing the cost and complexity of surgery. With the planar resection profile, shims or skid-like inserts that correlate to the distal-posterior condyles of the final insert may be attached to the distal femur after the preliminary bone resection to facilitate intraoperative trialing. The method and related components may also provide the ability of a surgeon to perform iterative intraoperative kinematic analysis and gap balancing, providing the surgeon the ability to perform necessary ligament and/or other soft tissue releases and fine tune the final implant positions based on data acquired during the surgery.

Data recovery of data symbols received in error

In one or more embodiments, a data processing apparatus is configured to receive data symbols transmitted from one or more endpoint devices. Each of the data symbols is transmitted in a respective temporal position assigned for communication by one of the plurality of endpoints. The data processing apparatus is configured to recover data from two or more transmission(s)/retransmission(s) (of the same data) that are received in error and have different temporal positions. The corresponding data symbols in error are phase-aligned per a common reference point and energy is accumulated therefrom. The data processing apparatus discerns correct data values from the accumulated energy.

Roof structure including panels and substructure for supporting panels

An outdoor building includes a plurality of vertical posts and a roof structure. The roof structure includes a substructure, a pair of side panels, and a pair of end panels. The substructure is coupled with the vertical posts via post brackets. The pair of side panels and the pair of end panels are coupled with the substructure. A method is also provided.

Morphologically curved sagittal wall of a tibial implant

Disclosed herein are methods of designing and fabricating prosthetic implants having a sagittal wall in which at least a portion thereof traverses a non-linear path. A method of fabricating such a prosthetic implant may include generating a virtual bone model based on image information obtained from at least one bone, determining a proposed height of the prosthetic implant at a first location on the virtual bone model, determining a proposed resection depth into the at least one bone at the first location based at least in part on the proposed height of the prosthetic implant, and determining a curved resection path across a portion of the virtual bone model. The curved resection path may intersect the first location and the prosthetic implant may have a curved sagittal wall corresponding to the curved resection path.

Tent electrical system

An electrical system ( 60, 200 ) for a tent or shelter ( 98, 201 ). Wires ( 60 ) are routed through a tent or shelter ( 98, 201 ) either by attaching the wires to the tent or shelter, running the wires through hems, seams ( 100 ), or sleeves, or integrating the wires into the fabric for the tent or shelter. In accordance with an embodiment, an appliance ( 208 ) is connected to the wiring harness ( 60 ) and is mounted or attached in the tent or shelter. The appliance ( 208 ) may be mounted in a socket ( 234 ) that includes contacts that may engage a fixture or appliance, such as a light. An opposite end of a cord ( 222 ) leading to the socket is attachable to an electrical power supply, such as a battery pack ( 203 ).

HYDROPROCESSING FOR LUBRICANT BASESTOCK PRODUCTION

Methods are provided for hydroprocessing a feed (such as hydrotreating, hydrocracking, or hydrofining a feed) to generate a product with a reduced or minimized aromatics content relative to the severity of the hydroprocessing conditions. In some types of hydroprocessing applications, it can be desirable to select the severity of hydroprocessing conditions to achieve a desired level of removal for sulfur, a desired level for removal of nitrogen, and/or a desired level for increasing the viscosity index of a feed. The severity for heteroatom removal and/or viscosity index uplift can also correspond to an amount of conversion of a feed to lower boiling point products, so the lowest severity conditions suitable for achieving a product quality can be desirable. By improving the aromatics saturation during hydroprocessing, the severity of subsequent aromatics saturation processes can be reduced. 1. A process for selectively hydroconverting a raffinate produced from solvent refining a lubricating oil feedstock , comprising:conducting the lubricating oil feedstock to a solvent extraction zone and separating therefrom an aromatics rich extract and a paraffins rich raffinate;stripping the raffinate of solvent to produce a raffinate feed having a dewaxed oil viscosity index from 80 to 105 and a final boiling point of no greater than 650° C.;passing the raffinate feed to a first hydroconversion zone and processing the raffinate feed in the presence of a mixed metal catalyst under hydroconversion conditions; andpassing the first hydroconverted raffinate to a second reaction zone and conducting cold hydrofinishing of the first hydroconverted raffinate in the presence of a hydrofinishing catalyst under cold hydrofinishing conditions,wherein the mixed metal catalyst comprises a sulfided mixed metal catalyst formed by sulfiding a mixed metal catalyst precursor composition, the mixed metal catalyst precursor composition being produced bya) heating a composition comprising at least ...

Intraoperative Dynamic Trialing

A dynamic trialing method generally allows a surgeon to perform a preliminary bone resection on the distal femur according to a curved or planar resection profile. With the curved resection profile, the distal-posterior femoral condyles may act as a femoral trial component after the preliminary bone resection. This may eliminate the need for a separate femoral trial component, reducing the cost and complexity of surgery. With the planar resection profile, shims or skid-like inserts that correlate to the distal-posterior condyles of the final insert may be attached to the distal femur after the preliminary bone resection to facilitate intraoperative trialing. The method and related components may also provide the ability of a surgeon to perform iterative intraoperative kinematic analysis and gap balancing, providing the surgeon the ability to perform necessary ligament and/or other soft tissue releases and fine tune the final implant positions based on data acquired during the surgery.

NOBLE METAL HYDROGENATION CATALYSTS AND AROMATIC SATURATION METHODS

Methods are provided for modifying hydrogenation catalysts having silica supports (or other non-alumina supports) with additional alumina, and using such catalysts to achieve unexpectedly superior hydrogenation of feedstocks. The modified hydrogenation catalysts can have a relatively low cracking activity while providing an increased activity for hydrogenation. 112.-. (canceled)13. A hydrogenation catalyst , comprising: 1.0 wt % to 2.5 wt %, based on a total catalyst weight, of alumina deposited on the silica support, the catalyst having a ratio of aluminum atoms in tetrahedral sites to octahedral sites of at least 1.0,', 'wherein the silica support comprises an amorphous silica support, a mesoporous silica support, or a combination thereof., '0.1 wt % to 5.0 wt %, based on total catalyst weight, of a Group VIII noble metal on a silica support; and'}14. The hydrogenation catalyst of claim 13 , wherein the Group VIII noble metal comprises Pt claim 13 , Pd claim 13 , or a combination thereof.15. The hydrogenation catalyst of claim 13 , wherein the Group VIII noble metal comprises Pt.16. The hydrogenation catalyst of claim 15 , wherein the Group VIII noble metal further comprises one or more of Pd claim 15 , Ir claim 15 , or Rh claim 15 , a molar ratio of Pt to the one or more of Pd claim 15 , Ir claim 15 , or Rh being at least 1:1.17. The hydrogenation catalyst of claim 13 , wherein the supported catalyst comprises 0.1 wt % to 2.0 wt % of the Group VIII noble metal.18. The hydrogenation catalyst of claim 13 , wherein the ratio of aluminum atoms in tetrahedral sites to octahedral sites is at least 1.5.19. The hydrogenation catalyst of claim 13 , wherein the catalyst comprises 1.0 wt % to 2.1 wt % of alumina deposited on the silica support.20. The hydrogenation catalyst of claim 13 , wherein the catalyst comprises 1.1 wt % to 2.2 wt % of alumina deposited on the silica support. This application is a continuation-in-part application of co-pending U.S. application Ser. No ...

Traction apparatus and methods

A brace and traction device and associated methods of operation. In one embodiment, the device incorporates a forwardly open head and jaw brace which is adjustably supported vertically above a forwardly collar member. The brace and the collar member are adapted such that the brace is able to mate with the collar member while still being able to rotate to the subject's left and right while remaining planar to the collar member. Adjustment may be accomplished for example manually or via an electronic motor controlled by a control mechanism and microprocessor. The microprocessor may be adapted to store information regarding a user's sessions, and facilitate communication with patient and physician personal devices, thus sending these data from recorded sessions. The processor element may also be adapted to implement therapy sessions based on physician-entered program specifications, or based on pre-programmed specifications.

A Hydrogenation Catalyst, Its Method of Preparation and Use

A method of preparing a hydrogenation catalyst, for example, a phthalate hydrogenation catalyst, comprising contacting a silica support having a median pore size of at least about 10 nm with a silylating agent to form an at least partially coated silica support, calcining said coated silica support to form a treated silica support, and depositing a noble metal, preferably ruthenium, on the treated silica support, and optionally contacting the treated silica support with an optional chelating agent to form the hydrogenation catalyst; a hydrogenation catalyst prepared by that method; and a method of hydrogenating unsaturated hydrocarbons, such as phthalates, in which an unsaturated hydrocarbon is contacted with hydrogen gas in the presence of the hydrogenation catalyst of the invention. 1. A method for the preparation of a silica-supported noble metal hydrogenation catalyst comprising the steps of:(a) contacting a silica support having a median pore size of at least about 10 nm with a silylating agent to coat at least part of the silica support to produce a coated silica support;(b) calcining the coated silica support obtained in step (a) to produce a treated silica support; and(c) depositing a noble metal on the treated silica support obtained in step (b) to produce a noble metal-containing silica support.2. The method of claim 1 , wherein the noble metal is selected from the group consisting of ruthenium claim 1 , rhodium claim 1 , palladium claim 1 , platinum claim 1 , and mixtures thereof.3. The method of claim 2 , wherein the noble metal is ruthenium.4. The method of claim 1 , wherein step (c) includes contacting the treated silica support obtained in step (b) with a solution comprising a noble metal salt and a chelating agent.5. The method of claim 4 , wherein the chelating agent was from 2 to 20 carbon atoms and comprising at least one carboxylic acid or hydroxyl functional group and at least one nitrogen-containing functional group claim 4 , the nitrogen- ...

Hydrogenation Catalyst, Its Method of Preparation and Use

A method of preparing a hydrogenation catalyst, for example, a phthalate hydrogenation catalyst, comprising contacting a silica support having a median pore size of at least about 10 nm with a silylating agent to form an at least partially coated silica support, calcining said coated silica support to form a treated silica support, and depositing a noble metal, preferably ruthenium, on the treated silica support, and optionally contacting the treated silica support with an optional chelating agent to form the hydrogenation catalyst; a hydrogenation catalyst prepared by that method; and a method of hydrogenating unsaturated hydrocarbons, such as phthalates, in which an unsaturated hydrocarbon is contacted with hydrogen gas in the presence of the hydrogenation catalyst of the invention. 123.-. (canceled)24. A method for the preparation of a silica-supported noble metal hydrogenation catalyst comprising the steps of:(a) providing a silica support having a median pore size of at least about 10 nm;(b) steam treating said silica support to increase the hydroxyl concentration on the surface of said silica support after streaming to produce a steamed silica support;(c) contacting said streamed silica support with a silylating agent to coat at least part of said streamed silica support to produce a coated silica support;(d) calcining said coated silica support obtained in step (c) to produce a treated and coated silica support; and(e) dispersing a noble metal by a chelating agent on said treated and coated silica support obtained in step (d) to produce said silica-supported noble metal hydrogenation catalyst having a median pore size of at least 10 nm and no more than 300 nm.25. The method of claim 24 , wherein said noble metal is selected from the group consisting of ruthenium claim 24 , rhodium claim 24 , palladium claim 24 , platinum claim 24 , and mixtures thereof.26. The method of claim 25 , wherein said noble metal is ruthenium.27. The method of claim 24 , wherein said ...

A Hydrogenation Catalyst, Its Method of Preparation and Use

A method of producing a hydrogenation catalyst, for example, a phthalate hydrogenation catalyst, comprising contacting a silica support having a medium pore size of at least about 10 nm with an acid to produce a treated silica support, and depositing a noble metal, preferably ruthenium, on the treated silica support to produce a noble metal-containing silica support, and optionally contacting the noble metal-containing silica support with a chelating agent to form the hydrogenation catalyst; a hydrogenation catalyst prepared by that method; and a method of hydrogenating unsaturated hydrocarbons, such as, phthalates, in which an unsaturated hydrocarbon is contacted with hydrogen gas in the presence of the hydrogenation catalyst of the invention. 1. A method for the preparation of a silica-supported noble metal hydrogenation catalyst comprising the steps of:(a) contacting a silica support having a median pore size of at least about 10 nm with an acid to make a treated silica support; and(b) depositing a noble metal on the treated silica support obtained in step (a) to produce a noble metal-containing silica support.2. The method of claim 1 , wherein the noble metal is selected from the group consisting of ruthenium claim 1 , rhodium claim 1 , palladium claim 1 , platinum and mixtures thereof.3. The method of claim 1 , wherein the noble metal is ruthenium.4. The method of claim 1 , wherein step (b) includes contacting the treated silica support obtained in step (a) with a solution comprising a noble metal salt and a chelating agent.5. The method of claim 4 , wherein the chelating agent comprises at least one carboxylic acid or hydroxyl functional group and at least one nitrogen-containing functional group claim 4 , the nitrogen-containing functional group being an amine or an imine and the chelating agent having from 2 to 20 carbon atoms.6. The method of claim 5 , wherein the chelating agent is triethanolamine.7. The method of claim 1 , further comprising the step of ...

Uses of salt-inducible kinase (sik) inhibitors

The present disclosure provides methods of treating and/or preventing inflammatory bowel disease (IBD) and graft-versus-host disease (GVHD) using salt-inducible kinase (SIK) inhibitors, such as macrocyclic SIK inhibitors of Formula (I), imidazolyl SIK inhibitors of Formula (II), and urea and carbamate SIK inhibitors of Formula (III-A) (e.g., urea and carbamate SIK inhibitors of Formula (III)).

Iridium-Containing Catalysts, Their Production and Use

A process is described for producing a catalyst composition comprising an iridium component dispersed on a support. In the process, silica-containing support is treated with an iridium compound and an organic compound comprising an amino group to form an organic iridium complex on the support. The treated support is then heated in an oxidizing atmosphere at a temperature of about 325° C. to about 475° C. to partially decompose the organic metal complex on the support. The treated support is then heated in a reducing atmosphere at a temperature of about 350° C. to about 500° C. to convert the partially decomposed organic iridium complex into the desired iridium component.

HYDROPROCESSING CATALYSTS AND THEIR PRODUCTION

The precursor of a hydroprocessing catalyst is made by impregnating a metal oxide component comprising at least one metal from Group 6 of the Periodic Table and at least one metal from Groups 8-10 of the Periodic Table with an amide formed from a first organic compound containing at least one amine group, and a second organic compound containing at least one carboxylic acid group. Following impregnation heat treatment follows to form in situ generated unsaturation additional to that in the two organic compounds. The catalyst precursor is sulfided to form an active, sulfide hydroprocessing catalyst. 1. (canceled)2. A method for hydroprocessing a biocomponent feedstock , comprising:exposing a biocomponent feedstock comprising a bio-derived fraction and a mineral oil fraction to a bulk mixed metal catalyst, in the presence of hydrogen under effective deoxygenation conditions, the bulk mixed metal catalyst comprising at least one Group VI metal selected from Mo and W and at least one Group VIII metal selected from Co and Ni; and forming a deoxygenated effluent.3. The method of claim 2 , wherein the bio-derived fraction makes up about 20 wt % of the biocomponent feedstock.4. The method of claim 2 , wherein the bio-derived fraction includes a lipids fraction claim 2 , wherein about 2 wt % to about 40 wt % of lipids in the lipids fraction claim 2 , based on the weight of the bio-derived fraction claim 2 , is sourced from algal sources.5. The method of claim 2 , wherein the deoxygenated effluent is substantially oxygen free.6. The method of claim 2 , wherein the dexoygenation conditions comprise a hydrogen partial pressure of from about 5 barg (0.5 MPag) to about 300 barg (30 MPag) claim 2 , a reaction temperature of from about 392° F. to about 842° F. (200° C. to 450° C.) claim 2 , a liquid hourly space velocity of from about 0.05 hrto about 10 hr claim 2 , and a hydrogen treat gas rate from about 200 scf/B (34 Nm/m) to about 10 claim 2 ,000 scf/B (1685 Nm/m).7. The method ...

Intraoperative dynamic trialing

A dynamic trialing method generally allows a surgeon to perform a preliminary bone resection on the distal femur according to a curved or planar resection profile. With the curved resection profile, the distal-posterior femoral condyles may act as a femoral trial component after the preliminary bone resection. This may eliminate the need for a separate femoral trial component, reducing the cost and complexity of surgery. With the planar resection profile, shims or skid-like inserts that correlate to the distal-posterior condyles of the final insert may be attached to the distal femur after the preliminary bone resection to facilitate intraoperative trialing. The method and related components may also provide the ability of a surgeon to perform iterative intraoperative kinematic analysis and gap balancing, providing the surgeon the ability to perform necessary ligament and/or other soft tissue releases and fine tune the final implant positions based on data acquired during the surgery.

Hydrogenation Catalyst, Its Method of Preparation and Use

A method of producing a hydrogenation catalyst, for example, a phthalate hydrogenation catalyst, comprising contacting a silica support having a medium pore size of at least about 10 nm with an acid to produce a treated silica support, and depositing a noble metal, preferably ruthenium, on the treated silica support to produce a noble metal-containing silica support, and optionally contacting the noble metal-containing silica support with a chelating agent to form the hydrogenation catalyst; a hydrogenation catalyst prepared by that method; and a method of hydrogenating unsaturated hydrocarbons, such as, phthalates, in which an unsaturated hydrocarbon is contacted with hydrogen gas in the presence of the hydrogenation catalyst of the invention. 116.-. (canceled)17. A silica-supported noble metal hydrogenation catalyst comprising a noble metal and a chelating agent dispersed on a porous silica support ,wherein the chelating agent has at least one carboxylic acid functional group or hydroxyl functional group and from 2 to 20 carbon atoms; andwherein the silica support has a median pore size of at least about 10 nm and no more than about 300 nm, a silica content of at least 60 wt %, and hydrogen to noble metal chemisorption ratio of at least about 0.50.18. The catalyst of claim 17 , wherein the noble metal is selected from the group consisting of ruthenium claim 17 , rhodium claim 17 , palladium claim 17 , platinum and mixtures thereof.19. The catalyst of claim 17 , wherein the noble metal is ruthenium.20. The catalyst of claim 17 , wherein the catalyst has a crush strength of at least 800 g/mm.21. A method of hydrogenating an unsaturated hydrocarbon claim 17 , comprising the step of contacting an unsaturated hydrocarbon with hydrogen gas in the presence of the silica-supported noble metal hydrogenation catalyst of .22. The method of claim 21 , wherein the unsaturated hydrocarbon is a phthalate.23. A method of hydrogenating an unsaturated hydrocarbon claim 21 , ...

HYDROPROCESSING CATALYSTS AND THEIR PRODUCTION

The precursor of a hydroprocessing catalyst is made by impregnating a metal oxide component comprising at least one metal from Group 6 of the Periodic Table and at least one metal from Groups 8-10 of the Periodic Table with an amide formed from a first organic compound containing at least one amine group, and a second organic compound containing at least one carboxylic acid group. Following impregnation heat treatment follows to form in situ generated unsaturation additional to that in the two organic compounds. The catalyst precursor is sulfided to form an active, sulfide hydroprocessing catalyst. 1. A process for producing an amide-containing catalyst precursor , the process comprising:(a) impregnating a catalyst precursor composition comprising a metal oxide form of (i) at least one metal from Group 6 of the Periodic Table of the Elements and (ii) at least one metal from Groups 8-10 of the Periodic Table of the Elements with a pre-formed amide made from a first organic compound containing at least one amine group and a second organic compound containing at least one carboxylic acid group, to form an organically treated catalyst precursor; and(b) heating the organically treated catalyst precursor at a temperature from about 150° C. to about 275° C. for a time sufficient to form additional in situ unsaturated carbon atoms not present in the first or second organic compounds, or both, but not for so long that the amide substantially decomposes.2. The process of in which the at least one metal from Group 6 is Mo claim 1 , W claim 1 , or a combination thereof claim 1 , and in which the at least one metal from Groups 8-10 is Co claim 1 , Ni claim 1 , or a combination thereof.3. The process of in which the at least one metal from Group 6 is tungsten.4. The process of in which the at least one metal from Group 8 is nickel.5. The process of in which the first organic compound comprises at least 10 carbon atoms.6. The process of in which the first organic compound ...

HYDROPROCESSING FEEDSTOCKS HAVING SILICON CONTENT

The present disclosure provides processes for hydroprocessing hydrocarbon feedstocks comprising a silicon content of about 1 wppm or greater. In at least one embodiment, a process includes introducing, in a reactor or to the reactor, a hydrocarbon feedstock having a silicon content of at least about 1 wppm, based on the total weight of the hydrocarbon feedstock, to a treat gas to produce a hydrocarbon feedstock/treat gas mixture. The process includes introducing the hydrocarbon feedstock/treat gas mixture to a catalyst composition comprising at least one group 6 metal and at least one group 8-10 metal, wherein the molar ratio of group 6 metal to group 8-10 metal is from about 10:1 to about 1:10. The process includes obtaining a liquid product comprising a sulfur content of 5,000 wppm or less. Furthermore, processes of the present disclosure provide hydroprocessing of high Si content feeds using hydrocarbon feeds at high liquid hourly space velocities. 1. A process comprising:introducing, in a reactor or to the reactor, a hydrocarbon feedstock having a silicon content of at least about 1 wppm, based on the total weight of the hydrocarbon feedstock, to a treat gas to produce a hydrocarbon feedstock/treat gas mixture;introducing the hydrocarbon feedstock/treat gas mixture to a catalyst composition comprising at least one group 6 metal and at least one group 8-10 metal, wherein the molar ratio of group 6 metal to group 8-10 metal is from about 10:1 to about 1:10; andobtaining a liquid product having a sulfur content of 5,000 wppm or less, based on the total weight of the liquid product.2. The process of claim 1 , wherein the hydrocarbon feedstock is introduced to the reactor at a feed rate of from about 0.05 hto about 100 h.3. The process of claim 1 , wherein the hydrocarbon feedstock has a sulfur content of about 15 wppm or greater claim 1 , based on the total weight of the hydrocarbon feedstock.4. The process of claim 1 , wherein the hydrocarbon feedstock has a ...

Surgical Plan Options For Robotic Machining

A method of performing surgery on a bone includes providing a robotically controlled bone preparation system and creating at least one hole in the bone with the robotically controlled bone preparation system prior to machining the bone. The bone hole aligns with a hole or a post in a guide for a manual cutting tool. If the robot fails during surgery, or if the surgeon does not wish to complete the procedure with the robot, the guide is attached to the bone after aligning the guide hole with the bone hole. The surgery is completed manually after the guide is attached to the bone, and the robot is not used after the guide is attached to the bone.

Improved Process for Hydrogenation of Benzenepolycarboxylic Acids and Derivatives Thereof

A process for ring hydrogenation of a benzenepolycarboxylic acid or derivative thereof, includes contacting a feed stream comprising the acid or derivative thereof with a hydrogen containing gas in the presence of a catalyst under hydrogenation conditions to produce a hydrogenated product, wherein the catalyst contains rhodium and ruthenium. 1. A process for ring hydrogenation of a benzenepolycarboxylic acid or derivative thereof , said process comprises the step of contacting a feed stream comprising said benzenepolycarboxylic acid or derivative thereof with a hydrogen-containing gas in the presence of a catalyst under hydrogenation conditions to produce a hydrogenated product , wherein said catalyst comprises ruthenium and rhodium applied to a support comprising from 97 to 100 wt. % silica.2. The process of claim 1 , wherein said benzenepolycarboxylic acid or derivative thereof is selected from the group consisting of C-Cphthalates claim 1 , C-Cterephthalates claim 1 , mixtures of Cand Cphthalates claim 1 , mixtures of Cand Cterephthalates claim 1 , mixtures of Cand Cphthalates claim 1 , and mixtures of Cand Cterephthalates.3. The process of claim 1 , wherein said catalyst comprises ruthenium in an amount of from 0.05 to 2.5 wt. % claim 1 , based on said total weight of the catalyst.4. The process of claim 1 , wherein said catalyst comprises rhodium in an amount of from 0.05 to 2.5 wt. % claim 1 , based on the total weight of said catalyst.5. The process of claim 1 , wherein said catalyst comprises ruthenium and rhodium in a weight ratio of from 0.1:1 to 10:1.6. The process of claim 1 , wherein said catalyst comprises ruthenium and rhodium in a total amount of from 0.2 to 2 wt % applied to said support material which comprises silica in an amount of from 99 to 100 wt. %.7. The process of claim 1 , wherein said process is carried out at a pressure of 20 to 220 bar claim 1 , a temperature of 50 to 150° C. claim 1 , a LVVH of from 1 to 5 hand a hydrogen excess of 50 ...

METHOD AND SYSTEM FOR PRODUCING LOW AROMATIC HYDROCARBON PRODUCTS

Methods are provided for modifying hydrogenation catalysts having silica supports (or other non-alumina supports) with additional alumina, and using such catalysts to achieve unexpectedly superior hydrogenation of feedstocks. The modified hydrogenation catalysts can have a relatively low cracking activity while providing an increased activity for hydrogenation. 1. A method for hydrogenating a feedstock , comprising:exposing a feedstock comprising a hydrocarbonaceous feed to a supported catalyst under effective hydrogenation conditions to form a hydrogenated effluent, the supported catalyst comprising 0.1 wt % to 5.0 wt % of a Group VIII noble metal on a silica support, the supported catalyst further comprising about 0.3 wt % to about 2.5 wt % alumina deposited on the silica support, the supported catalyst having a ratio of aluminum atoms in tetrahedral sites to octahedral sites of at least 1.0.2. The method of claim 1 , wherein the hydrocarbonaceous feed comprises a diesel boiling range portion.3. The method of claim 1 , wherein the hydrocarbonaceous feed comprises about 50 wppm of sulfur or less.4. The method of claim 1 , wherein the catalyst comprises about 0.3 wt % to about 2.1 wt % alumina deposited on the silica support.5. The method of claim 1 , wherein the catalyst comprises about 0.5 wt % to about 2.2 wt % alumina deposited on the silica support.6. The method of claim 1 , wherein the effective hydrogenation conditions comprise a temperature from about 75° C. to about 425° C.; a hydrogen partial pressure from about 100 psi (0.7 MPa) to about 3000 psi (20.7 MPa); a liquid hourly space velocity from about 0.1 hrto about 5 LHSV; and a hydrogen treat gas rate of from about 36 Sm/mto about 1780 Sm/m(200 SCF/B to 10000 SCF/B).7. The method of claim 1 , wherein the Group VIII noble metal comprises Pt.8. The method of claim 7 , wherein the Group VIII noble metal further comprises one or more of Pd claim 7 , Ir claim 7 , or Rh claim 7 , a molar ratio of Pt to the one ...

NOBLE METAL HYDROGENATION CATALYSTS AND AROMATIC SATURATION METHODS

Methods are provided for modifying hydrogenation catalysts having silica supports (or other non-alumina supports) with additional alumina, and using such catalysts to achieve unexpectedly superior hydrogenation of feedstocks. The modified hydrogenation catalysts can have a relatively low cracking activity while providing an increased activity for hydrogenation. 1. A method for forming a lubricant boiling range product , comprising:exposing a 600° F.+ (316° C.+) portion of a hydrocracked effluent to a supported catalyst under effective hydrogenation conditions to form a hydrogenated effluent, the supported catalyst comprising 0.1 wt % to 5.0 wt % of a Group VIII noble metal on a silica support, the supported catalyst further comprising 0.3 wt % to 2.5 wt % alumina deposited on the silica support, the supported catalyst having a ratio of aluminum atoms in tetrahedral sites to octahedral sites of at least 1.0;dewaxing the hydrogenated effluent under catalytic dewaxing conditions to form a dewaxed effluent; andhydrofinishing at least a portion of the dewaxed effluent under hydrofinishing conditions to form a hydrofinished effluent comprising a lubricant boiling range product.2. The method of claim 1 , further comprising exposing a feedstock comprising a lubricant boiling range portion to a hydrocracking catalyst under hydrocracking conditions to form the hydrocracked effluent; andseparating the hydrocracked effluent to form a fraction comprising the 600° F.+ (316° C.+) portion of the hydrocracked effluent.3. The method of claim 2 , wherein the feedstock comprises a hydrotreated feedstock.4. The method of claim 3 , wherein the hydrotreated feedstock comprises a hydrotreated effluent claim 3 , the hydrotreated effluent being cascaded to the hydrocracking catalyst without intermediate separation.5. The method of claim 1 , wherein the 600° F.+ (316° C.+) portion of the hydrocracked effluent comprises 50 wppm or less of sulfur.6. The method of claim 1 , wherein the catalyst ...

Selective inhibition of gluconeogenic activity

The present invention provides compounds, pharmaceutical compositions and methods for treating and/or preventing a metabolic condition, such as diabetes.

Noble metal hydrogenation catalysts with low cracking activity

Methods are provided for modifying hydrogenation catalysts having silica supports (or other non-alumina supports) with additional alumina, and using such catalysts to achieve unexpectedly superior hydrogenation of feedstocks. The modified hydrogenation catalysts can have a relatively low cracking activity while providing an increased activity for hydrogenation.

PROCESSING OF HEAVY HYDROCARBON FEEDS

Systems and methods are provided for hydroconversion of a heavy oil feed under slurry hydroprocessing conditions and/or solvent assisted hydroprocessing conditions. The systems and methods for slurry hydroconversion can include the use of a configuration that can allow for improved separation of catalyst particles from the slurry hydroprocessing effluent. In addition to allowing for improved catalyst recycle, an amount of fines in the slurry hydroconversion effluent can be reduced or minimized. This can facilitate further processing or handling of any “pitch” generated during the slurry hydroconversion. The systems and methods for solvent assisted hydroprocessing can include processing of a heavy oil feed in conjunction with a high solvency dispersive power crude. 115.-. (canceled)16. A process for producing a hydroprocessed product , comprising:{'sup': '−1', 'exposing a combined feedstock comprising a heavy oil feed component and at least about 5 wt % of a High Solvency Dispersive Power (HSDP) crude component to a hydroprocessing catalyst under effective fixed bed hydroprocessing conditions to form a hydroprocessed effluent, the effective fixed bed hydroprocessing conditions including a pressure of about 1500 psig (˜10.3 MPa) or less, a temperature of at least about 360° C., and a liquid hourly space velocity of the fraction of the combined feedstock boiling above 1050° F. (˜566° C.) of at least about 0.10 hr,'}the HSDP crude component having a TAN of at least about 0.3 and a solubility blending number of at least about 75, the HSDP crude component optionally comprising an aromatics content of at least about 50 wt %.17. The process of claim 16 , wherein the HSDP crude component has a 10% distillation point of at least about 800° F. (˜427° C.).18. The process of claim 16 , wherein the heavy oil feed component has a 10% distillation point of at least about 900° F. (˜482° C.).19. The process of claim 16 , wherein the effective fixed bed hydroprocessing conditions are ...

PROCESSING OF HEAVY HYDROCARBON FEEDS

Systems and methods are provided for hydroconversion of a heavy oil feed under slurry hydroprocessing conditions and/or solvent assisted hydroprocessing conditions. The systems and methods for slurry hydroconversion can include the use of a configuration that can allow for improved separation of catalyst particles from the slurry hydroprocessing effluent. In addition to allowing for improved catalyst recycle, an amount of fines in the slurry hydroconversion effluent can be reduced or minimized. This can facilitate further processing or handling of any “pitch” generated during the slurry hydroconversion. The systems and methods for solvent assisted hydroprocessing can include processing of a heavy oil feed in conjunction with a high solvency dispersive power crude. 120.-. (canceled)21. A process for producing a hydroprocessed product , comprising:passing a feedstock comprising resid to a first reactor operating at about 1000 psig (˜6.9 MPag) or less,demetallizing at least about 60 wt % and up of the feedstock to create a liquid product,passing the liquid product from the first reactor to a fractionator,separating out in the fractionator a heavy residuum fraction having a boiling point of about 1050° F. (˜566° C.),passing the heavy residuum fraction from the fractionator to a second reactor operating at from about 1500 psig (˜10.4 MPag) to about 3400 psig (˜23.5 MPag).22. The process of claim 21 , wherein the temperature of first reactor is between 650° F. (˜343° C.) and 850° F. (˜454° C.).23. The process of claim 21 , wherein demetallizing further comprises exposing the feedstock to a demetallization catalyst at a pressure of about 300 psig (˜2.1 MPag) to about 800 psig (˜5.6 MPag) and a temperature of about 600° F. (˜316° C.) to about 1000° F. (˜538° C.).24. The process of claim 23 , whereina) the demetallization catalyst has a mean pore diameter of 60 Å or less,{'sup': 2', '3, 'b) the demetallization catalyst comprises a catalyst with a surface area of at least ...

Manganese-spinel catalysts in CO/H2 olefin synthesis

Single phase, unsupported, Group IA or IIA metal salt promoted manganese-containing iron spinel catalysts, having Fe:Mn atomic ratios of 2:1 or above, have been found to be highly active for the selective conversion of CO/H 2 to alpha olefins.

Method for the production of hydrocarbons using iron-carbon-based catalysts

This invention relates to a promoted finely divided or supported iron carbide-based catalyst which is produced by a gas phase pyrolytic decomposition reaction driven by a laser and the use of such a catalyst to produce various heavier hydrocarbons from CO and H 2 .

Hydroprocessing catalysts and their production

In a process for producing a hydroprocessing catalyst, a particulate metal oxide composition comprising an oxide of at least one first metal selected from Group 6 of the Periodic Table of the Elements can be mixed with particles of a sulfide of at least one second metal selected from Groups 8 to 10 of the Periodic Table of the Elements to produce a particulate catalyst precursor. The particulate catalyst precursor can then be sulfided under conditions sufficient to at least partially convert the particulate catalyst precursor into a layered metal sulfide having defect sites associated with the second metal sulfide.

Stabilized blends containing friction modifiers

The present invention relates to functional fluid compositions containing friction modifiers, and specifically stable compositions containing friction modifiers with limited solubility in and/or limited compatibility with the functional fluids with which they are used. In particular the present invention deals with functional fluids used in internal combustion engines, such as engine oils, and friction modifiers derived from hydroxy-carboxylic acids, where the friction modifier is present in the functional fluid composition at levels that would otherwise cause the composition to be unstable and/or hazy.

Stabilized blends containing friction modifiers

The present invention relates to functional fluid compositions containing friction modifiers, and specifically stable compositions containing friction modifiers with limited solubility in and/or limited compatibility with the functional fluids with which they are used. In particular the present invention deals with functional fluids used in internal combustion engines, such as engine oils, and friction modifiers that contain one or more amide functional groups, where the friction modifier is present in the functional fluid composition at levels that would otherwise cause the composition to be unstable and/or hazy.

Ion tolerant corrosion inhibitors and inhibitor combinations for fuels

This invention relates to compositions and methods for inhibiting corrosion and deposit formation in fuel handling equipment, with reduced or eliminated incidence of fuel filter plugging and internal diesel injector deposits (IDID) in the equipment that eventually employs the final commercially blended form of the fuel. More specifically, the invention relates to inhibiting corrosion from the walls of fuel pipelines and storage equipment and preventing deposits in engines.

Manganese-spinel catalysts in CO/H2 olefin synthesis

Single phase, unsupported, Group IA or IIA metal salt promoted manganese-containing iron spinel catalysts, having Fe:Mn atomic ratios of 2:1 and above, have been found to be highly active for the selective conversion of CO/H 2 to alpha olefins.

High surface area dual promoted iron/managanese spinel compositions

Slurried, high surface area, Cu and Group IA or IIA dual metal promoted Mn-Fe spinels which are fully reduced and carburized provide exceptionally high catalytic activity and selectivity in the conversion ofCo/H 2 to alpha-olefins, particularly when reduced and carbided in-situ. These copper and Group IA or IIA metal promoted iron-manganese catalysts maintain good activity and selectively under low pressure reaction conditions.

Promoted iron-cobalt spinel catalyst for Fischer-Tropsch processes

Iron-cobalt spinels which contain low levels of cobalt, in an iron/cobalt atomic ratio of 7:1 to 35:1, are converted to Fischer-Tropsch catalysts upon reduction and carbiding that exhibit high activity and selectivity to C 2 --C 6 olefins and low CH 4 production.

Fischer-Tropsch hydrocarbon synthesis with copper promoted iron/cobalt spinel catalyst

Slurried, high surface area, copper promoted Fe-Co spinels which are fully reduced/carburized provide exceptionally high activity and selectivity in the conversion of CO/H 2 to alpha-olefins. These copper promoted iron-cobalt catalysts maintain good activity and selectivity under low pressure reaction conditions.

Cobalt-promoted catalysts for use in Fischer-Tropsch slurry process

Slurried low initial surface area Fe--Co spinels, containing low levels of cobalt, which are fully reduced/carburized ex situ, provide exceptionally high activity and selectivity in the conversion of CO/H 2 to alpha olefins in a slurry type process. These slurried unsupported iron-cobalt catalysts maintain good activity and selectivity under low pressure reaction conditions.

Process for preparing high surface area iron/cobalt Fischer-Tropsch slurry catalysts

Slurried high surface area Fe-Co spinels which are fully reduced/carburized provide exceptionally high activity and selectivity in the conversion of CO/H 2 to alpha-olefins. These iron-cobalt catalysts maintain good activity and selectivity under low pressure reaction conditions.

Fischer-Tropsch hydrocarbon synthesis with high surface area Cu and K promoted reduced-carbided iron/manganese spinels

Slurried, high surface area, Cu and Group IA or IIA dual metal promoted Mn-Fe spinels which are fully reduced and carburized provide exceptionally high catalytic activity and selectivity in the conversion of CO/H 2 to alpha-olefins, particularly when reduced and carbided in-situ. These copper and Group IA or IIA metal promoted iron-manganese catalysts maintain good activity and selectivity under low pressure reaction conditions.

Process for preparing high surface area iron/cobalt Fischer-Tropsch slurry catalysts

Slurried high surface area Fe-Co spinels which are fully reduced/carburized provide exceptionally high activity and selectivity in the conversion of CO/H 2 to alpha-olefins. These iron-cobalt catalysts maintain good activity and selectivity under low pressure reaction conditions.

Copper promoted iron/cobalt spinels and their preparation

Slurried, high surface area, Cu promoted Fe-Co spinels which are fully reduced/carburized provide exceptionally high activity and selectivity in the conversion of CO/H 2 to alpha-olefins, particularly when carbided in-situ in the reactor. These copper iron-cobalt catalysts maintain good activity and selectivity under low pressure reaction conditions.

Manganese - spinel catalysts in co/h.sub.2 olefin synthesis

OLEFIN SYNTHESIS ABSTRACT OF THE DISCLOSURE Single phase, unsupported, Group IA or IIA metal salt promoted manganese-containing iron spinel catalysts, having Fe:Mn atomic ratios of 2:1 or above, have been found to be highly active for the selective conversion of CO/H2 to alpha olefins.

Promoted iron-carbon-based catalysts produced in the presence laser radiation

This invention relates to a promoted finely divided or supported iron carbide-based catalyst which is produced by a gas phase pyrolytic decomposition reaction driven by a laser and the use of such a catalyst to produce various heavier hydrocarbons from CO and H 2 .

Iron carbide-based catalyst produced in the presence of laser radiation

This invention relates to a finely divided iron carbide-based catalyst which is produced by a gas phase pyrolytic decomposition reaction driven by a laser. The catalysts may be used to produce various hydrocarbons, including olefins, from CO and H 2 .

Laser produced iron carbide-based catalysts

This invention relates to a finely divided iron carbide-first row transition metal-based catalyst which is produced by a gas phase pyrolytic decomposition reaction driven by a laser. The catalysts may be used to produce various hydrocarbons, including olefins, from CO 2 and H 2 .

Method for producing olefins from H2 and CO2 using an iron carbide based catalyst

This invention relates to a process for producing C 2 -C 20 olefins from a feed stream consisting of H 2 and CO 2 using an iron-carbide based catalyst.

Iron-zinc based catalysts for the conversion of synthesis gas to alpha-olefins

New copper-potassium promoted iron-zinc catalysts wherein the iron:zinc atomic ratio is 5:1 or greater, exhibit improved activity, selectivity and stability in the synthesis of alpha-olefins from hydrogen and carbon monoxide.

Method and apparatus for assessing hemodynamic parameters and blood vessel location within the circulatory system of a living subject

An improved method and apparatus for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises a method of measuring a hemodynamic parameter by measuring a non-calibrated value of the parameter non-invasively, and inducing a stress of the circulatory system while measuring a second parameter. The response of the circulatory system to the stress is determined directly from the subject, and a calibration function is derived from the response and applied to the non-calibrated measured value to produce a calibrated measure of the actual value of the hemodynamic parameter. Methods of using backscattered acoustic energy for determination of hemodynamic markers are also disclosed.

Control circuit with automatic DC offset

An automatic gain control circuit in the feedback path for a laser wavelength control circuit is described herein. This gain control circuit automatically adjusts the amplification of the analog signals output from a photodetector array, where the array detects a fringe pattern created by a laser beam. Another feature of the preferred embodiment feedback circuit is the automatic setting of a DC offset voltage that compensates for errors in the feedback path and enables an accurate determination of a dark level signal in the fringe pattern signal. This dark level signal provides a reference for measuring the magnitude of the fringe pattern signal. Varying photodetector outputs may now be more accurately measured. The preferred embodiment feedback circuit also employs a very fast amplifier anti-saturation circuit using LED's connected in a clamp circuit.

Laser wavelength control circuit having automatic DC offset and gain adjustment

An automatic gain control circuit in the feedback path for a laser wavelength control circuit is described herein. This gain control circuit automatically adjusts the amplification of the analog signals output from a photodetector array, where the array detects a fringe pattern created by a laser beam. Another feature of the preferred embodiment feedback circuit is the automatic setting of a DC offset voltage that compensates for errors in the feedback path and enables an accurate determination of a dark level signal in the fringe pattern signal. This dark level signal provides a reference for measuring the magnitude of the fringe pattern signal. Varying photodetector outputs may now be more accurately measured. The preferred embodiment feedback circuit also employs a very fast amplifier anti-saturation circuit using LED's connected in a clamp circuit.

Polymer Alkylation of hydroxyaromatic compounds

A process for alkylating hydroxyaromatic compounds with a terminally unsaturated polymer in the presence of a partially or completely dehydrated heteropoly catalyst. The alkylated hydroxyaromatic compounds so formed are useful as precursors for the production of fuel and lubricant additives.

Exhaust control apparatus

Deacetylase inhibitors and uses thereof

The present invention provides novel compounds of formula (I) and pharmaceutical compositions thereof. The inventive compounds are useful as deacetylase inhibitors (e.g., histone deacetylase inhibitors) and may be useful in the treatment of proliferative diseases such as cancer. In particular, the inventive compounds are HDAC6 inhibitors. The invention also provide synthetic methods for preparing the inventive compounds.

Histone deacetylases, and uses related thereto

The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.

Dimerization catalyst and process therefor

A solid, acid catalyst, supported or unsupported, comprised of an anion modified Group IVB oxide is used to dimerize C 3 or C 4 containing feedstreams.

Stabilized blends containing friction modifiers

The present invention relates to functional fluid compositions containing friction modifiers, and specifically stable compositions containing friction modifiers with limited solubility in and/or limited compatibility with the functional fluids with which they are used. In particular the present invention deals with functional fluids used in internal combustion engines, such as engine oils, and friction modifiers derived from hydroxy-carboxylic acids, where the friction modifier is present in the functional fluid composition at levels that would otherwise cause the composition to be unstable and/or hazy.

Method of preparing a hydrotreating catalyst on a support containing a rare earth metal

This invention relates to supported multi-metallic catalysts for use in the hydroprocessing of hydrocarbon feeds, as well as a method for preparing such catalysts. The catalysts are prepared from a catalyst precursor comprised of at least one Group VIII metal and a Group VI metal and an organic agent selected from the group consisting of amino alcohols and amino acids.

Method for stabilizing titania supported cobalt catalyst and the catalyst for use in Fischer-Tropsch process

A method of preparing catalyst compositions of cobalt composited with ternary metal oxide supports of substituted titania having the general formula Co/Ti x M 1-x O 2 where x ranges from 0.01 to 0.14 and M is selected from the group consisting of silicon, zirconium, and tantalum and wherein the titania is an anatase polymorph stable under oxidative regeneration temperatures from about 400° to about 750° C.

Molecular sieve catalyst composition, its making and use in conversion processes

The invention relates to a molecular sieve catalyst composition, to a method of making or forming the molecular sieve catalyst composition, and to a conversion process using the catalyst composition. In particular, the invention is directed to a making a molecular sieve catalyst composition by forming a slurry by combining a molecular sieve, a binder and a matrix material, wherein the slurry has a pH, above or below the isoelectric point of the molecular sieve. The catalyst composition has improved attrition resistance, particularly useful in a conversion process for producing olefin(s), preferably ethylene and/or propylene, from a feedstock, preferabl y an oxygenate containing feedstock.

Quaternary ammonium functionalized dendrimers and methods of use therefor

Quaternary ammonium functionalized dendrimers are described which are suitable for controlling the growth of microorganisms. The quaternary ammonium functionalized dendrimer biocides of the present invention are effective against a wide variety of microbial species including bacteria, spores, yeast, fungi, mold and multicellular microorganisms.

Coprocessing of biofeeds with group VI metal catalysts

Feedstocks containing biocomponent materials are coprocessed with mineral feeds using a Group VI metal catalyst prior to hydrodesulfurization of the feedstocks. The Group VI metal catalyst is optionally a physically promoted Group VI metal catalyst.

Hydroprocessing catalysts and their production

Described herein is a catalyst precursor composition comprising at least one metal from Group 6 of the Periodic Table of the Elements, at least one metal from Groups 8-10 of the Periodic Table of the Elements, and a reaction product formed from (i) a first organic compound containing at least one amine group, and (ii) a second organic compound separate from said first organic compound and containing at least one carboxylic acid group. A process for preparing the catalyst precursor composition is also described, as is sulfiding the bulk mixed metal oxide catalyst precursor composition to form a hydroprocessing catalyst.

Hydroprocessing using bulk Group VIII/Group VIB catalysts (HEN-9901)

Hydroprocessing of petroleum and chemical feedstocks using bulk Group VIII/Group VIB catalysts. Preferred catalysts include those comprised of Ni-Mo-W.

Hydroprocessing catalysts and their production

Described herein is a catalyst precursor composition comprising at least one metal from Group 6 of the Periodic Table of the Elements, at least one metal from Groups 8-10 of the Periodic Table of the Elements, and a reaction product formed from (i) a first organic compound containing at least one amine group and at least 10 carbon atoms or (ii) a second organic compound containing at least one carboxylic acid group and at least 10 carbon atoms, but not both, wherein the reaction product contains additional unsaturated carbon atoms, relative to the first or second organic compound, wherein the metals of the catalyst precursor composition are arranged in a crystal lattice, and wherein the reaction product is not located within the crystal lattice. A process for preparing the catalyst precursor composition is also described, as is sulfiding the catalyst precursor composition to form a hydroprocessing catalyst.

Bulk bi-metallic catalysts made from precursors containing an organic agent

Bulk bi-metallic catalysts for use in the hydroprocessing of hydrocarbon feeds, as well as a method for preparing such catalysts. The catalysts are prepared from a catalyst precursor containing an organic agent.

Hydroprocessing catalysts and their production

Described herein is a catalyst precursor composition comprising at least one metal from Group 6 of the Periodic Table of the Elements, at least one metal from Groups 8-10 of the Periodic Table of the Elements, and a reaction product formed from (i) a first organic compound containing at least one amine group, and (ii) a second organic compound separate from said first organic compound and containing at least one carboxylic acid group. A process for preparing the catalyst precursor composition is also described, as is sulfiding the bulk mixed metal oxide catalyst precursor composition to form a hydroprocessing catalyst.

Hydroprocessing catalysts and their production

In a process for producing a hydroprocessing catalyst, a particulate metal oxide composition comprising an oxide of at least one first metal selected from Group 6 of the Periodic Table of the Elements, preferably molybdenum and tungsten, can be mixed with particles of a sulfide of at least one second metal selected from Groups 8 to 10 of the Periodic Table of the Elements, preferably nickel and cobalt, to produce a particulate catalyst precursor. The particulate catalyst precursor can then be sulfided under conditions sufficient to at least partially convert the particulate catalyst precursor into a layered metal sulfide having defect sites associated with the second metal sulfide.

Hydroprocessing catalysts and their production

In a process for producing a hydroprocessing catalyst, a particulate metal oxide composition comprising an oxide of at least one first metal selected from Group 6 of the Periodic Table of the Elements can be mixed with particles of a sulfide of at least one second metal selected from Groups 8 to 10 of the Periodic Table of the Elements to produce a particulate catalyst precursor. The particulate catalyst precursor can then be sulfided under conditions sufficient to at least partially convert the particulate catalyst precursor into a layered metal sulfide having defect sites associated with the second metal sulfide.

Hydroprocessing catalysts and their production

In a process for producing a hydroprocessing catalyst, a particulate metal oxide composition comprising an oxide of at least one first metal selected from Group 6 of the Periodic Table of the Elements can be mixed with particles of a sulfide of at least one second metal selected from Groups 8 to 10 of the Periodic Table of the Elements to produce a particulate catalyst precursor. The particulate catalyst precursor can then be sulfided under conditions sufficient to at least partially convert the particulate catalyst precursor into a layered metal sulfide having defect sites associated with the second metal sulfide.

Bulk bi-metallic catalysts made from precursors containing an organic agent

Bulk bi-metallic catalysts for use in the hydroprocessing of hydrocarbon feeds, as well as a method for preparing such catalysts. The catalysts are prepared from a catalyst precursor containing an organic agent.

Bulk bimetallic catalysts, method of making bulk bimetallic catalysts and hydroprocessing using bulk bimetallic catalysts

The invention relates to a process for upgrading hydrocarbonaceous feedstreams by hydroprocessing using bulk bimetallic catalysts. More particularly, the invention relates to a catalytic hydrotreating process for the removal of sulfur and nitrogen from a hydrocarbon feed such as a fuel or a lubricating oil feed. The catalyst is a bulk catalyst comprising a Group VIII metal and a Group VIB metal.

Hydroprocessing catalysts and their production

In a process for producing a hydroprocessing catalyst, a particulate metal oxide composition comprising an oxide of at least one first metal selected from Group 6 of the Periodic Table of the Elements can be mixed with particles of a sulfide of at least one second metal selected from Groups 8 to 10 of the Periodic Table of the Elements to produce a particulate catalyst precursor. The particulate catalyst precursor can then be sulfided under conditions sufficient to at least partially convert the particulate catalyst precursor into a layered metal sulfide having defect sites associated with the second metal sulfide.

Hydroprocessing catalysts and their production

The precursor of a hydroprocessing catalyst is made by impregnating a metal oxide component comprising at least one metal from Group 6 of the Periodic Table and at least one metal from Groups 8-10 of the Periodic Table with an amide formed from a first organic compound containing at least one amine group, and a second organic compound containing at least one carboxylic acid group. Following impregnation heat treatment follows to form in situ generated unsaturation additional to that in the two organic compounds. The catalyst precursor is sulfided to form an active, sulfide hydroprocessing catalyst.

Hydroprocessing catalysts and their production

The precursor of a hydroprocessing catalyst is made by impregnating a metal oxide component comprising at least one metal from Group 8 of the Periodic Table and at least one metal from Groups 8-10 of the Periodic Table with an amide formed from a first organic compound containing at least one amine group, and a second organic compound containing at least one carboxy!ic acid group. Following impregnation heat treatment follows to form in situ generated unsaturation additional to that in the two organic compounds. The catalyst precursor is sulfided to form an active, sulfide hydroprocessing catalyst.

Nickel molybodtungstate hydrotreating catalysts (law444)

A hydrodenitrogenation catalyst is prepared by decomposing a nickel (ammonium) molybdotungstate precursor and sulfiding, either pre-use or in situ, the decomposition product.

Process for upgrading naphtha

A method for upgrading a naphtha feed to a naphtha product containing less than about 10 wppm of nitrogen and less than about 15 wppm sulfur, the method comprising contacting said naphtha feed with hydrogen in the presence of a bulk multimetallic catalyst under effective reactor conditions to hydrodesulfurize and hydrodenitrogenize said naphtha feed to produce said naphtha product, wherein said bulk multimetallic catalyst comprises at least one Group VIII non-noble metal and at least two Group VIB metals.

Bulk Ni-Mo-W catalysts made from precursors containing an organic agent

Novel bulk tri-metallic catalysts for use in the hydroprocessing of hydrocarbon feeds, as well as a method for preparing such catalysts. The catalysts are prepared from a catalyst precursor containing an organic agent.

Bulk ni-mo-w catalysts made from precursors containing an organic agent

Novel bulk tri-metallic catalysts for use in the hydroprocessing of hydrocarbon feeds, as well as a method for preparing such catalysts. The catalysts are prepared from a catalyst precursor containing an organic agent.

Processing of heavy hydrocarbon feeds

Systems and methods are provided for hydroconversion of a heavy oil feed under slurry hydroprocessing conditions and/or solvent assisted hydroprocessing conditions. The systems and methods for slurry hydroconversion can include the use of a configuration that can allow for improved separation of catalyst particles from the slurry hydroprocessing effluent. In addition to allowing for improved catalyst recycle, an amount of fines in the slurry hydroconversion effluent can be reduced or minimized. This can facilitate further processing or handling of any "pitch" generated during the slurry hydroconversion. The systems and methods for solvent assisted hydroprocessing can include processing of a heavy oil feed in conjunction with a high solvency dispersive power crude.

Processing of heavy hydrocarbon feeds

Systems and methods are provided for hydroconversion of a heavy oil feed under slurry hydroprocessing conditions and/or solvent assisted hydroprocessing conditions. The systems and methods for slurry hydroconversion can include the use of a configuration that can allow for improved separation of catalyst particles from the slurry hydroprocessing effluent. In addition to allowing for improved catalyst recycle, an amount of fines in the slurry hydroconversion effluent can be reduced or minimized. This can facilitate further processing or handling of any “pitch” generated during the slurry hydroconversion. The systems and methods for solvent assisted hydroprocessing can include processing of a heavy oil feed in conjunction with a high solvency dispersive power crude.

Hydroprocessing catalysts and their production

In a process for producing a hydroprocessing catalyst, a particulate metal oxide composition comprising an oxide of at least one first metal selected from Group 6 of the Periodic Table of the Elements can be mixed with particles of a sulfide of at least one second metal selected from Groups 8 to 10 of the Periodic Table of the Elements to produce a particulate catalyst precursor. The particulate catalyst precursor can then be sulfided under conditions sufficient to at least partially convert the particulate catalyst precursor into a layered metal sulfide having defect sites associated with the second metal sulfide.

Hydroprocessing catalysts and their production

In a process for producing a hydroprocessing catalyst, a particulate metal oxide composition comprising an oxide of at least one first metal selected from Group 6 of the Periodic Table of the Elements, preferably molybdenum and tungsten, can be mixed with particles of a sulfide of at least one second metal selected from Groups 8 to 10 of the Periodic Table of the Elements, preferably nickel and cobalt, to produce a particulate catalyst precursor. The particulate catalyst precursor can then be sulfided under conditions sufficient to at least partially convert the particulate catalyst precursor into a layered metal sulfide having defect sites associated with the second metal sulfide.

Hydroprocessing catalysts and their production

In a process for producing a hydroprocessing catalyst, a particulate metal oxide composition comprising an oxide of at least one first metal selected from Group 6 of the Periodic Table of the Elements can be mixed with particles of a sulfide of at least one second metal selected from Groups 8 to 10 of the Periodic Table of the Elements to produce a particulate catalyst precursor. The particulate catalyst precursor can then be sulfided under conditions sufficient to at least partially convert the particulate catalyst precursor into a layered metal sulfide having defect sites associated with the second metal sulfide.

Hydroprocessing catalysts and their production

In a process for producing a hydroprocessing catalyst, a particulate metal oxide composition comprising an oxide of at least one first metal selected from Group 6 of the Periodic Table of the Elements can be mixed with particles of a sulfide of at least one second metal selected from Groups 8 to 10 of the Periodic Table of the Elements to produce a particulate catalyst precursor. The particulate catalyst precursor can then be sulfided under conditions sufficient to at least partially convert the particulate catalyst precursor into a layered metal sulfide having defect sites associated with the second metal sulfide.

Hydroprocessing catalysts and their production

In a process for producing a hydroprocessing catalyst, a particulate metal oxide composition comprising an oxide of at least one first metal selected from Group 6 of the Periodic Table of the Elements can be mixed with particles of a sulfide of at least one second metal selected from Groups 8 to 10 of the Periodic Table of the Elements to produce a particulate catalyst precursor. The particulate catalyst precursor can then be sulfided under conditions sufficient to at least partially convert the particulate catalyst precursor into a layered metal sulfide having defect sites associated with the second metal sulfide.

Hydroprocessing using hydrothermally-prepared bulk multimetallic catalysts

Bone pads

Implante protésico (400) que comprende una superficie articular (420); y una superficie de contacto con el hueso (424) opuesta a la superficie articular, en el que la superficie de contacto con el hueso presenta una zona anterior (421), una zona exterior (422) y una zona posterior (423), que corresponden a unas superficies discretas de contacto y cada una de entre las zonas anterior, exterior y posterior presentan un perfil de tolerancia más estricto que otros aspectos del implante protésico, y que la zona anterior (421), la zona exterior (422) y la zona posterior (423) están diseñadas para acoplarse con el hueso preparado (310) que presenta una zona anterior (321), una zona exterior (322) y una zona posterior (323) respectivas, estando el implante protésico (400) caracterizado por que la zona anterior presenta un primer perfil de tolerancia, la zona exterior presenta un segundo perfil de tolerancia y la zona posterior presenta un tercer perfil de tolerancia, presentando cada una de entre las zonas anterior (421), exterior (422) y posterior (423) un perfil de tolerancia diferente. Prosthetic implant (400) comprising an articular surface (420); and a bone contact surface (424) opposite the articular surface, in which the bone contact surface has an anterior zone (421), an outer zone (422) and a posterior zone (423), which they correspond to discrete contact surfaces and each one of the anterior, external and posterior zones has a more strict tolerance profile than other aspects of the prosthetic implant, and that the anterior zone (421), the exterior zone (422) and the posterior area (423) are designed to engage with the prepared bone (310) having an anterior zone (321), an external zone (322) and a posterior zone (323) respectively, the prosthetic implant (400) being characterized in that The anterior zone has a first tolerance profile, the outer zone has a second tolerance profile and the posterior zone has a third tolerance profile, each one presenting between the ...

Nickel molybdotungstate hydrotreating catalysts

A hydrodenitrogenation catalyst is prepared by decomposing a nickel (ammonium) molybdotungstate precursor and sulfiding, either pre-use or in situ, the decomposition product.

Hydroprocessing using bulk bimetallic catalysts

The invention relates to a process for upgrading hydrocarbonaceous feedstreams by hydroprocessing using bulk bimetallic catalysts. More particularly, the invention relates to a catalytic hydrotreating process for the removal of sulfur and nitrogen from a hydrocarbon feed such as a fuel or a lubricating oil feed. The catalyst is a bulk catalyst containing a Group VIII metal and a Group VIB metal.