Sample Solution Tube and Detection Device

Abstract The present disclosure provides a sample solution tube and a detection device. At least one first protrusion, a circular truncated cone-like side wall and an external thread are arranged on an outer surface of a side wall of the sample solution tube. The present disclosure further provides a detection device including the sample solution tube, which is provided with a liquid storage slot, a liquid sealing piece, chromatographic test paper, and a puncturing mechanism in sequence from bottom to top; an upper surface of the liquid storage slot is provided with an opening; the opening is sealed by the liquid sealing piece; and the liquid sealing piece is openable. By the adoption of the technical solutions, a sealing effect can be better guaranteed; and moreover, the sample solution tube is in threaded connection with a housing of the detection device, so that the connection structure is stabler. After a detection result is recorded, the liquid sealing piece can be opened, and then ...

Magnetic and gravitational separation and comprehensive utilization of vonsenite

The present invention relates to comprehensive utilization of mineral resource. Through stepped grinding, stepped magnetic separation, combined magnetic separation-gravitational separation, B and Fe in vonsenite are separated to produce B concentrate, which is used in producing borax, and B-Fe concentrate, which is used in producing iron and steel product and high activity boron-rich sludge. The present invention enriches B2O3 of raw mineral into B concentrate mainly and Fe into B-Fe concentrate through effective separation and provides high-grade and high-activity un-expensive material for boron producing industry while utilizing reasonably the separated Fe concentrate.

PRC1 INHIBITORS AND METHODS OF TREATMENT THEREWITH

Provided herein are small molecule inhibitors of Polycomb Repressive Complex 1 (PRC1) activity, and methods of use thereof for the treatment of disease, including leukemia and other cancers, as well as other diseases dependent on the activity of PRC1.

Novel sulfonyl substituted benzophenone oxide compounds, prepraring method and application thereof

The present invention relates to the field of medical technology, and in particular relates to a category of novel sulphonyl substituted xanthene ketone compounds that have a structural formula shown as follows, a preparation method and application thereof. The compound has high inhibitory activity for ACAT1/ACAT2; most of the compounds have high inhibitory activity for acyl coenzyme A cholesterol acyltransferase (ACAT). The compounds can be used for preparing anti-atherosclerosis drug combination. Furthermore, the compounds can be used as a preventive or a treating agent of such diseases as angina, myocardial infarction, cerebral infarction, apoplexy, Alzheimer's disease, acute coronary syndrome, PTCA or restenosis of coronary artery after a bracket is arranged. The compounds can be used as a treating agent to adjust the function of sebaceous glands of the skin and inhibit the excessive generation of sebum. And the compounds can be used for treating such diseases as acne-like damage caused ...

Method for detecting contents of 14 antibiotics in edible parts of crabs

The invention discloses a method for detecting the content of 14 antibiotics in edible parts of crabs. The method specifically comprises the following steps: (1) preparing a standard solution; (2) extracting an aqueous two-phase system; and (3) carrying out ultra-high performance liquid chromatography-tandem mass spectrometer (UPLC-MS/MS) determination. According to the method, the extraction solvent, the water phase proportion, the addition amount of formic acid in the extraction solvent and the split-phase salt are optimized, meanwhile, the appropriate internal standard substance is selected, the residual conditions of 14 antibiotics in the edible part of the crab can be detected at a time, and the method has the advantages of being high in recovery rate, sensitivity and stability, low in detection limit, real and reliable in detection result and the like; good application prospects are realized.

Substituted aryl matrine compounds, preparation method and applications thereof

The invention relates to substituted aryl matrine compounds. The structural formula of the matrine compounds is represented in the description, wherein in the formula the R represents mono-substituted aryl/ multi-substituted aryl/substituted naphthalene ring. The invention also provides pharmaceutically-acceptable salts of the matrine compounds, a preparation method, and applications thereof. The cell experiment results show that the substituted aryl matrine compounds and pharmaceutically-acceptable salts thereof have a prominent inhibiting effect on a human liver cancer cell strain (Hun-7), a prominent activity on preventing liver cancer, and a great potential on the preparation of drugs for treating hepatic fibrosis and liver cancer. Moreover, the toxicity of the matrine compounds and salts thereof is low, and the matrine compounds and salts thereof can be used to prepare drugs for treating related inflammatory diseases, in which cell factors and nuclear transcription factors NF[kappa ...

Combined supporting structure of cantilever plate

The invention relates to a combined supporting structure of a cantilever plate, and belongs to the field of cantilever plates, the combined supporting structure comprises a wall body, a pouring box is mounted on the wall body, a feeding hole is formed in the pouring box, a first feeding pipe is arranged on the pouring box, the first feeding pipe is communicated with the feeding hole, a second feeding pipe is arranged outside the pouring box, and the second feeding pipe is communicated with the feeding hole. And an exhaust hole is formed in the pouring box. According to the cantilever plate, concrete is conveyed into the pouring box through the second feeding pipe and the first feeding pipe, when the pouring box is filled with the concrete, conveying of the concrete is stopped, and the pouring box is dismantled after the concrete is solidified, so that the possibility that gaps are generated in the pouring box after the concrete is solidified is reduced, and the structural strength of the ...

Intelligent monitoring method aiming at well drilling overflowing and leakage

The invention discloses an intelligent monitoring method aiming at well drilling overflowing and leakage, belonging to the well drilling monitoring technology. On the basis of the existing hardware device, the method comprehensively utilizes the information of a plurality of site sensors, imitates the experience of experts to put forward the reasonable judgment of accidents such as overflowing, leakage and the like as well as the regulation of alarm control, and realizes automatic monitoring and alarm control by a computer. By using the method, the capability of treating multiple information of the computer can be fully exerted, automatic monitoring wok can be realized under the unsupervised condition, leads the alarm of accidents to be more timely and accurate, reduces the probability offalse alarm, and well solves the problems in oil field well drilling production.

Aluminum industry data supplementary acquisition method and device, medium and electronic equipment

The invention relates to the technical field of aluminum industry, and discloses an aluminum industry data supplementary acquisition method and device, a medium and electronic equipment. The method comprises the steps that a data supplementary collection task list in a preset database is obtained every preset time interval; performing data supplementary collection on supplementary collection tasks in the data supplementary collection task list in sequence; monitoring the collection state of the supplementary collection task; after each supplementary collection task is completed, a collection record is generated; converting first target data corresponding to the supplementary collection task into storable data in an ORC format based on the collection record; and storing the storable data to a hadoop data platform or storing first target data corresponding to the supplementary collection task to a relational database based on the collection record. According to the method and the device, ...

Gene Amplification Tube and Test Cassette

Abstract The present disclosure provides a gene amplification tube and a test cassette. The gene amplification tube includes a tube body and a cap. The tube body is provided with an opening at the top and is sealed at the bottom, the cap seals the opening at the top of the tube body, the tube body includes a side tube wall and a bottom tube wall, the side tube wall includes a cylindrical side tube wall and a conical side tube wall located below the cylindrical side tube wall, the bottom tube wall is provided with a recessed area recessed toward the inside of the tube body, and a thickness of the bottom tube wall in the recessed area is less than a thickness of the side tube wall. By adopting the gene amplification tube in the present disclosure in which the bottom of the gene amplification tube is provided with a recess and the wall thickness at the bottom is set to be smaller, compared with the scotch protruding out of the tube body in the prior art, the gene amplification tube can be ...

Application of matrine compounds in preparing anti-hepatic fibrosis and anti-liver cancer medicaments

The invention relates to application of compounds and salt thereof, and particularly relates to application of matrine compounds and salt thereof in preparation of anti-hepatic fibrosis and anti-liver cancer medicaments. The compounds have the advantages of remarkably inhibiting the proliferation of hepatoma cell lines Hep-G2, Hun-7, MHCC-97L, SMMC-7721 and Hep-3B and proliferation activities of fibroblast BJ, human hepatic stellate cells LX-2 and hepatic stellate cells HSC-T6, and can be used for preparing medicaments for treating hepatic fibrosis and liver cancer.

Application of 12-acetoxycoccinic acid to preparation of drug for preventing and controlling HCV (hepatitis C virus)

The invention relates to application of a compound, in particular to application of the compound, that is, 12-acetoxycoccinic acid, to preparation of a drug for treating or preventing the HCV (hepatitis C virus) disease. The invention further provides application of the 12-acetoxycoccinic acid to preparation of a food and a health product for liver protection. The tetracyclic triterpenoids compound, that is, the 12-acetoxycoccinic acid, has remarkable anti-HCV activity, can be used for preparing the drug for resisting HCV. The invention provides a new source for searching drugs for resisting the HCV.

Treatment of aluminum electrolytic-cell waste lining

Xanthol derivative and application thereof

The invention discloses a xanthohumol derivative, the structural general formula of which is selected from one of the following structures: according to the xanthohumol derivative prepared by the invention, pharmacological experiments show that the compound can promote proliferation and differentiation of osteoblasts and has good anti-osteoporosis activity, especially the activity of a C compound is relatively good, and the compound can be used for preparing anti-osteoporosis drugs. The compound can be used for preparing anti-osteoporosis medicines.

N-acetyl neuraminic acid compounds, medicine compositions thereof and preparation methods and purposes thereof

The invention discloses N-acetyl neuraminic acid compounds shown as the following general formula, medicine compositions thereof and preparation methods and purposes thereof. The compounds can inhibite surface neuraminidase of influenza viruses, thereby resisting the influenza viruses, in particular treating the infections of the influenza viruses resistant to other influenza-resistant medicaments, such as Zanamivir, Oseltamivir and the like.

Matrine derivative and preparation method thereof

The invention relates to a matrine derivative and salts thereof, and in particular relates to a novel matrine derivative having a chemical formula as shown in the specification, and salts thereof; in the formula, X is a sulphur atom, n is 1 or 2, R1 is one selected from alkyl, alkoxy, aryl and substituted aryl, and R2 is one selected from hydrogen, alkyl and substituted alkyl. The invention further provides a matrine derivative and a preparation method of the salts of the matrine derivative. The preparation method is high in productive rate, and prepared compounds are good in antitumour effect and have the advantages of being targeted, low in toxicity and the like; the target molecules obtained by the preparation method are high in stability. Activities of part of the compounds are significantly better than that of the compound M19.

Aluminum electrolysis carbon anode oxidation coating and coating method thereof

The invention relates to an oxidation resistant coating for aluminum electrolytic carbon anode and a coating method thereof. The method is characterized in that the surface of the aluminum electrolytic carbon anode is provided with an anti-oxidation coating formed by dried and mixed coat which is sprayed on the surface of the electrode, wherein the mixed coat comprises the following compositions in weight percentage: 1 to 25 percent of bisphenol A-type waterborne epoxy resin, 0.1 to 16 percent of boron carbide, 2 to 13 percent of boric acid and/or boric oxide, 15 to 50 percent of alumina, 0 to 20 percent of pseudo-boehmite, 10 to 30 percent of alumina sol, 0.1 to 0.3 percent of foam suppressor, and the balance being water. The coating and the method adopt an alumina-based gradient boron carbide oxidation resistant coating with a multilayer structure, and effectively blocks the contact of air and CO2 with carbon anode carbon, thereby avoiding or reducing excessive consumption of the carbon ...

Intelligent physiotherapeutic bed

The invention provides an intelligent physical therapy bed, which stimulates synthesis, coordination and change of human body by making use of various stimulation means such as sound, color, light, touch, etc., to affect micro-movement rate of nervous system and remove the unbalance of nervous system movement, thus realizing removal of bad mood and prevention of psychological disease. The human body is lightly stimulated so as to restrain activities of central nervous and realize low balance of the nervous system movement, thus improving sleep quality, curing nerve, improving performances of pressure resistance and long-time concentration, preventing diseases such as neurasthenia, high blood pressure, etc.; the human body is strongly stimulated so as to improve movement rate of peripheral and central nerves and achieve high balance of nervous system movement, thus eliminating tension, fear of human, improving reaction speed and stability of behaviors, bringing psychological and physiological ...

Similar target segmentation method based on weight set similarity movable contour model

The invention relates to the field of image processing, mode recognizing and computer application, in particular to a similar target segmentation method based on a weight set similarity movable contour model. The similar target segmentation method based on the weight set similarity movable contour model comprises the steps that multiple remarkable areas in which people are interested are extracted from a source image set containing multiple similar targets; the similarities of the common properties of each remarkable area and the multiple similar targets and the corresponding weights are evaluated; the movable contour model based on the weight set similarity and an energy function are established through the cooperation between the acquired weights and the remarkable areas; finally, a stable segmentation result is obtained by optimizing the energy function, and thus segmentation of similar targets in multiple images is achieved. According to the similar target segmentation method based ...

N-acetylneuraminic acid compounds, pharmaceutical composition, preparation method and uses thereof

N-acetylneuraminic acid compounds of formula as follows, a pharmaceutical composition, a preparation method and uses thereof are disclosed. The compounds can inhibit surface neuraminidase of influenza virus, thus can be used for resisting influenza virus, especially, for treating infections caused by the influenza virus which has resistance to other anti-flu drugs such as zanamivir and oseltamivir.

Method for extracting iron from lean hematite ore

A method for extracting iron from lean and impure hematite belongs to the technical field of mineral processing, comprising the following steps: (1) breaking the lean and impure hematite and coal until the grain size is below 10mm; obtaining the lean and impure hematite powder and coal powder; (2) evenly mixing the lean and impure hematite powder and the coal powder; (3) putting the mixed powders into a reducing furnace for deep reduction; (4) putting the materials into water for water quenching; (5) removing coal with magnetic separation equipments, grinding ore to the point that the grain size is below 0.1mm and then conducting magnetic separation, or milling to the degree that the grain size is below 0.1mm and then conducting magnetic separation, thus obtaining iron-containing products. The iron grade of the iron-containing products obtained by the method of the invention is above 70%, the iron grade of ore concentrate is up to 85-95% and the recovery rate of iron is above 85%.

Alkali-compensating method in production process of aluminium oxide

Novel sulfonyl substituted benzophenone oxide compounds, prepraring method and application thereof

The present invention relates to the field of medical technology, and in particular relates to a category of novel sulphonyl substituted xanthene ketone compounds that have a structural formula as shown in the right, a preparation method and application thereof. The compound has high inhibitory activity for ACAT1/ACAT2; most of the compounds have high inhibitory activity for acyl coenzyme A cholesterol acyltransferase (ACAT). The compounds can be used for preparing anti-atherosclerosis drug combination. Furthermore, the compounds can be used as a preventive or a treating agent of such diseases as angina, myocardial infarction, cerebral infarction, apoplexy, Alzheimer's disease, acute coronary syndrome, PTCA or restenosis of coronary artery after a bracket is arranged. The compounds can be used as a treating agent to adjust the function of sebaceous glands of the skin and inhibit the excessive generation of sebum. And the compounds can be used for treating such diseases as acne-like damage ...

Word document generation method and device based on JSON data

The invention relates to a word document generation method and device based on JSON (JavaScript Object Notation) data, electronic equipment and a computer readable medium. The method comprises the following steps: generating a plurality of underlying data modules corresponding to chapters, tables and charts on the basis of JSON (JavaScript Object Notation) data; extracting a common function and an association relationship to generate a word style template; real-time online operation of a user is obtained, and an operation instruction is generated; loading a bottom layer data module according to the operation instruction to generate an XML format file; and compressing the XML format file so as to convert the XML format file into a word document which is displayed in real time. According to the word document generation method and device based on the JSON data, the electronic equipment and the computer readable medium, the problems that in the prior art, the dependency on the running environment ...

Treatment of aluminum electrolytic cell waste refractory materials

Glycosylated derivative of cyclic peptide compounds and preparation method and application thereof

The invention relates to a glycosylated derivative of cyclic peptide compounds. The chemical structural formula of the glycosylated derivative of cyclic octapeptide TunicyclinD is shown in the specification, wherein n is equal to 0, 1 or 2; Glycosyl is monosaccharide or disaccharide, the monosaccharide is glucose, galactose, xylose, rhamnose, mannose, ribose, glucosamine or n-acetylglucosamine; the disaccharide is maltose or lactose. The invention also provides a preparation method and application of the glycosylated derivative of the cyclic peptide compounds. The compounds provided by the invention have relatively strong in-vitro antifungal activity, thereby being capable of being used for preparing antifungal drugs; the preparation method provided by the invention is used for successfully introducing different glycosyls on carboxyl of TunicyclinD, and is simple in process and high in yield. The formula is shown in the specification.

Head gesture recognition technology-based wheelchair control method

The invention provides a head gesture recognition technology-based wheelchair control method, and belongs to the field of artificial intelligence technology. A wheelchair body is provided with an image acquisition device, a computation and control unit, a bracket and a motor. When the wheelchair is used, the image acquisition device acquires a head image of a wheelchair user in real time and transmits the head image to the computation and control unit. The computation unit processes, analyzes and computes the image to acquire human face and nose position information and judges the head gesture of the user according to the human face and nose position information. According to the acquired head gesture, the computation and control unit generates a corresponding control command. Finally, the motor drives the wheelchair to move according to the acquired control command. Based on a non-contact image sensing and detecting method, the distribution condition of the human face gesture and thenose ...

Head gesture recognition technology-based wheelchair control method

The invention provides a head gesture recognition technology-based wheelchair control method, and belongs to the field of artificial intelligence technology. A wheelchair body is provided with an image acquisition device, a computation and control unit, a bracket and a motor. When the wheelchair is used, the image acquisition device acquires a head image of a wheelchair user in real time and transmits the head image to the computation and control unit. The computation unit processes, analyzes and computes the image to acquire human face and nose position information and judges the head gesture of the user according to the human face and nose position information. According to the acquired head gesture, the computation and control unit generates a corresponding control command. Finally, the motor drives the wheelchair to move according to the acquired control command. Based on a non-contact image sensing and detecting method, the distribution condition of the human face gesture and the nose ...

Device for preparing hot-press carbon-containing pellet

The invention provides a device for preparing a hot-press carbon-containing pellet, belonging to the technical field of metallurgy. The device comprises a fine iron powder heating machine, wherein the fine iron powder heating machine and a coal powder heating machine are connected together in series through a hot wind pipeline; the outlet of the fine iron powder heating machine is connected with the inlet of an iron powder buffer hopper; the outlet of the coal powder heating machine is connected with the inlet of a coal powder buffer hopper; the outlet of the iron powder buffer hopper and theoutlet of the coal powder buffer hopper are respectively connected with a mixing bunker through an iron powder constant feeder and a coal powder constant feeder; the outlet of the mixing bunker is connected with the inlet of a powerful mixer; the outlet of the powerful mixer is connected with the inlet of a high pressure thermal state briquette press through a pipeline; a raw coke oven gas removing ...

Dibenzyl butane type lignan LCA derivative and application thereof

The invention discloses a dibenzyl butane type lignan LCA derivative or a pharmaceutical salt thereof, the structure of which is shown in the specification. Pharmacological experiments of the dibenzyl butane type lignan LCA derivative prepared by the invention show that the compound has obvious anti-inflammatory activity, can obviously inhibit the release of inflammatory factors, and can be used for preparing anti-inflammatory drugs. The compound can be used for preparing anti-inflammatory drugs for rheumatoid arthritis and other diseases.

Octapeptide, cyclic octapeptide and derivatives, preparation method and application in preparation of antitumor drugs

The invention discloses octapeptide, cyclic octapeptide and derivatives, a preparation method and application in preparation of antitumor drugs. The amino acid residue sequence of the octapeptide S3 disclosed by the invention is as follows: Asp-Ser-Phe-Gly-Leu-Ser-Trp-Leu, and the amino acid residue sequence of the octapeptide S3 is as follows: Asp-Ser-Phe-Gly-Leu; the cyclic octapeptide S4 is a cyclized product of S3, and the amino acid residue sequence of the cyclic octapeptide S4 is Cyclo (Ser-Phe-Gly-Leu-Ser-Trp-Leu-Asp). Experimental results show that the octapeptide and the derivative thereof can significantly enhance the expression of two proteins, namely TIMP-1 and TIMP-2, and inhibit the activity of MMP-2 and MMP-9, so that the ability of non-small cell lung cancer A549 cell metastasis and invasion is weakened, and a way is provided for treatment of malignant tumors.

Crude liquid desilicon method for producing aluminium oxide

A process for desiliconizing the coarse liquid generated during preparing alumina features that the dealuminated dregs as the by-product of recovering Ga is used as the desiliconizing additive, and includes such steps as adding Baeyer-method red mud, desiliconizing reaction, adding the said desiliconizing additive whose surface has been activated, further reaction for 1-3 hr, and solid-liquid separation. Its advantage is high efficiency.

Method for fusing reducing iron by employing iron ore hot pressing carbon-containing agglomerate

Disclosed is a smelting reduction iron making method by iron ore hot pressing carbon bearing lump into shaft furnace, which takes iron concentrate hot pressing carbon bearing lump as raw material and shaft furnace as smelting reduction reactor. Smelting reduction iron is done by injecting pulverized coal into the shaft furnace with industrial oxygen, hot air or high oxygen hot air agitated; the iron bearing power of iron concentrate hot pressing carbon bearing lump is iron concentrate powder; the hot pressing pulverized coal is bituminous coal powder; quicklime acts as flux; the weight percent of each group is as follow: iron concentrate powder 60 to 75 percent, bituminous coal powder 20 to 35 percent and the quicklime powder 20 to 35 percent; iron concentrate pulverized coal hot pressing lump is fed through double bell mix feeding system at the top of the shaft furnace and is preheated, reduced and smelted in the shaft furnace; the pulverized coal is injected from a tuyere of the shaft ...

A preparation method of candesartan cilexetil and intermediates thereof

Bayer process stripping additive and its preparation and using method

A stripping additive of Baeyer method for decreasing the Al/Si ratio and Na/Si ratio in stripped red mud is hydrated calcium ferriote (3CaO.Fe2O3.6H2O). Its preparing process includes such steps as proportionally mixing calcium carbonate with hematite, calcining at 1000-1300 deg.C for 30-120 min to obtain calcium ferrite, grinding, proportionally mixing it with CaO, reaction at 25-60 deg.C for 4-10 hr, and hydrating by adding lime milk.

Process for preparing vardenafil and its intermediates

The invention provides a process for preparing vardenafil and its intermediates. The process is novel. The invention also provides new intermediates for preparing vardenafil and their preparation methods. The process for preparing vardenafil decreased side reactions in the methods of the prior art and other steps, improved yield and is easy operated, thus has excellent industrial applicability.

Novel triazolols antifungal compound, preparation method and application thereof

The invention relates to the medical technology field, in particular to a new triazole alcohols antifungal compound and salts thereof with the following chemical structure formula and a preparation method and the application thereof; R1 is selected from n-propyl, isopropyl or butyl; R2 is selected from alkyl or halogen; the salts include hydrochloride, hydrobromide and methane sulphonate. The compound has strong antifungal activity on various fungi in shallow parts and deep parts. Compared with the antifungal medicines used in the existing clinical applications, the compound has the advantages of high efficiency, low toxicity, broad antifungal spectrum, etc., which can be used for preparing new antifungal medicines.

Lithium ion battery multi-stage active and passive protection battery module

The lithium ion battery multi-stage active and passive protection battery module comprises a lithium ion battery body and a metal shell, a heat control mechanism is arranged on the inner side of the metal shell, the lithium ion battery body is arranged on the inner side of the heat control mechanism, a tab, a pressure release valve and a flame retardant agent are arranged at the upper end of the lithium ion battery body, and the lithium ion battery body is arranged on the inner side of the heat control mechanism. A liquid cooling plate is arranged at the bottom of the inner side of the metal shell, the lithium ion battery body is arranged at the upper end of the liquid cooling plate, an energy directional guide pipe is fixedly installed on the inner side of the upper end of the metal shell, a fire-resistant and pressure-resistant cover plate is arranged on the inner side of the energy directional guide pipe, and a one-way spray valve is arranged at the upper end of the fire-resistant and ...

Flow load moving method, device, equipment and readable medium

The invention discloses a traffic load moving method, which comprises the following steps: receiving a traffic load, and sending the traffic load to a corresponding partition based on a partition distribution table; monitoring the flow load value of each partition, and judging whether the partition is a hotspot partition or not based on the flow load value; in response to the fact that the partition becomes the hot spot partition, starting part of instances in the hot spot partition in the idle partition, and moving the corresponding flow load in the hot spot partition to the idle partition after starting is completed; and updating the partition distribution table based on the change of the partition where the instance is located, and sending the newly received traffic load to the corresponding partition based on the updated partition distribution table. The invention further discloses a corresponding device, computer equipment and a medium. According to the method, the service availability ...

Stapling peptide of targeted pan-Ras protein and application

The invention discloses a stapled peptide targeting pan-Ras protein and application, a straight-chain peptide Ac-WIGRLLTEIRHRLRNGN-NH2 as shown in SEQ ID NO.1 is used as a peptide chain template, amino acids at the i < th > site and the (i + 4) < th > site are replaced by 2-amino-2-methyl-6-heptenoic acid and cyclized to obtain the stapled peptide, i is any integer of 2, 4, 5, 6, 8, 9 and 11, and RH is L-homoarginine. The stapled peptide disclosed by the invention can inhibit proliferation of cancer cells in a dose-dependent manner, and has a relatively strong proliferation inhibition effect on K-Ras, N-Ras and H-Ras; meanwhile, the polypeptide has excellent cell penetrating capability, and can penetrate through a cell membrane to enter cytoplasm, so that target protein in cells can be better targeted to play a biological function, and meanwhile, cancer cell apoptosis can also be promoted. Therefore, the stable conformation of the alpha H helix of CHDSOS-5 can be kept through the stapled ...

Method for preparing catechin compound

The invention relates to a method for preparing a catechin compound. The method comprises the following steps: by taking 2,4,6-trihydroxy acetophenone and p-hydroxy benzaldehyde as raw materials, carrying out condensation reaction, restored deoxidation, cyclization reaction of acid catalysis, so as to obtain the catechin compound. The invention also provides a technology for producing the catechin compound. In the synthesis process of an immediate 9, reduction is carried out by using sodium borohydride which is catalyzed by a lewis acid, so that side reaction caused by double bond transfer is greatly reduced while a highly toxic reagent osmium tetroxide is replaced with hydrogen peroxide oxidation.

Method for fusing and reducing iron by employing iron ore hot pressing carbon-containing agglomerate

Disclosed is a smelting reduction iron making method by iron ore hot pressing carbon bearing lump into shaft furnace, which takes iron concentrate hot pressing carbon bearing lump as raw material andshaft furnace as smelting reduction reactor. Smelting reduction iron is done by injecting pulverized coal into the shaft furnace with industrial oxygen, hot air or high oxygen hot air agitated; the iron bearing power of iron concentrate hot pressing carbon bearing lump is iron concentrate powder; the hot pressing pulverized coal is bituminous coal powder; quicklime acts as flux; the weight percentof each group is as follow: iron concentrate powder 60 to 75 percent, bituminous coal powder 20 to 35 percent and the quicklime powder 20 to 35 percent; iron concentrate pulverized coal hot pressinglump is fed through double bell mix feeding system at the top of the shaft furnace and is preheated, reduced and smelted in the shaft furnace; the pulverized coal is injected from a tuyere of the shaft furnace ...

Pyramid house

Preparation of Alipioxazole

Production of alipiperazole is carried out by reacting 4-halogen-1-butyl alcohol with 7-hydroxy-3, 4-dihydro-2(1H)-chinoketone. Its advantages include higher polarity and purity, less by-reaction, and easy crystallization.

A preparation method of candesartan cilexetil and intermediates thereof

A preparation method of candesartan cilexetil and intermediates thereof. A compound of formula I, wherein R1 is chloride, bromide, iodide, hydroxy, sulfonyl, mesyl, p-tosyloxy, methanesulfonyloxy, acetoxy, benzoyloxy, or dimethylmercapto group. A preparation method of candesartan cilexetil from the compound of formula I. The material used in the method is stable.

Preparation method of aluminate base blue color fluorescent powder

Preparation method and application of scorpion toxin-derived cell-penetrating polypeptide

The invention relates to the technical field of biomedical engineering, and provides a preparation method and application of a scorpion toxin-derived cell-penetrating polypeptide. According to the invention, an OpiCalcin1 polypeptide is optimized in a truncation manner, and two polypeptides, namely, Opi1 17-33 CSKKCKRRGTNPEKRCR and Opi1 23-33 RRGTNPEKRCR, which are excellent in transmembrane function and relatively low in cytotoxicity, are provided. Experiments prove that the two cell-penetrating peptides are excellent in cell-penetrating effect and low in cell toxicity, meanwhile, the defect that time and labor are wasted when a complete sequence of scorpion toxin OpiCalcin1 is synthesized is overcome, the two cell-penetrating peptides can be used for preparing transporters of drugs, nuclear localization sequences, probes and the like, and the targeting efficiency is improved. Compared with a traditional method using scorpion venom as a medicine, the scorpion venom is synthesized to explore ...

Heat-insulating coating material for aluminum electrolytic inert anode and use thereof

The invention discloses a heat-insulating coating material for an aluminum electrolytic inert anode. The heat-insulating coating material consists of Me3AlF6 and Al2O3 fibers, wherein Me is at least one of Na, K and Li. The using method of the heat-insulating coating material comprises the following steps of: mixing materials according to the weight percentage of the components of the heat-insulating coating material for the aluminum electrolytic inert anode; coating the mixed material on the outer surface of the aluminum electrolytic inert anode or the inert anode set, wherein the coating thickness of the mixed material is between 1.5 and 5.0 centimeters; and then heating to 850 to1,010 DEG C and calcining for 4 to 24 hours to obtain the inert anode of inert anode set coated with the heat-insulating coating material. In the heat-insulating coating material, the polycrystalline Al2O3 fiber with high chemical stability, heat resistance and high anti-shock and toughening performance is used ...

Method for storing and managing dynamic data based on 'impounding reservoir' principle

The invention discloses a method for storing and managing dynamic data based on an 'impounding reservoir' principle, which relates to real-time storage and management of a large number of dynamic data and belongs to the field of data storage and information processing. Aiming at the problems existing in the aspects of integrity and real-time property for the single use of a database or a file container, the invention provides the idea of an 'impounding reservoir' container. The data are stored in the 'impounding reservoir' container and the file container respectively. The 'impounding reservoir' mainly stores current data, and the volume of the 'impounding reservoir' changes dynamically so as to ensure the real-time property of data processing and result display. A plurality of files are used for storing original data so as to ensure the integrity of data storage and the timeliness and the accuracy of history playback. The method for storing and managing a large number of the dynamic data ...

Alkali-compensating method in process of aluminium oxide

The invention relates to a method for supplementing alkali in the alumina production process by using mixed joint method for compensating alkali loss in Bayer process system. It is characterized by that CaO is added to the carbon component mother liquor in sintering method to make causticization reaction, the peralkali concentration of carbon component mother liquor of sintering method in 60g/l-150g/l by Na2O, the addition amount of CaO is 50%-200% of chemometrics, causticizatino reaction temp. is 80 deg.C-100 deg.C, and the causticization time is 1-3 hr. Said method can change the sodium carbonate in the carbon component mother liquor into caustic sodium NaOH, after the causticization reaction the sodium carbonate component in the solution is equal to seed component mother liquor.

Non-reference image quality evaluation method based on gradient relevance

The invention provides a non-reference image quality evaluation method based on gradient relevance, and belongs to computer image analysis. The method comprises the following steps: firstly, determining three sub-characters, namely, an image gradient amplitude character, an image gradient direction change character and an image gradient amplitude change character, which are easily influenced by distortion in an image gradient; performing M*M image blocking on the three characters, and determining a statistic variance of the three characters in each image block, wherein the average number of the statistic variances of all the image blocks in the whole image is taken as an image characteristic; and finally, determining the image quality by combining a support vector with a two-step frame in image quality evaluation. The method provided by the invention has the advantages of being small in time complexity, high in subjective consistency, low in image feature dimension and good in universality ...

Sulfur/nitrogen-containing azole antifungal compound as well as preparation method and application of sulfur-containing azoles antifungal compound

The invention is a sulfur/nitrogen-containing azole antifungal compound as well as a preparation method and an application of the sulfur/nitrogen-containing azole antifungal compound, relates to the technical field of medicine. The sulfur/nitrogen-containing azole antifungal compound is a novel azole antifungal compound and has a chemical structural formula which is shown in the specification, wherein, R1 is hydrogen or a straight-chain or branched-chain saturated or unsaturated lower alkyl having 1-6 carbon atoms; R2 is selected from hydrogen, alkyl, halogen, cyano group, a nitro group, an amino and an alkoxy, can be located at the ortho, meta or para position of the benzene ring and can be monosubstituted or polysubstituted. The invention also provides a preparation method and an application of the compound. The compound disclosed by the invention has strong antifungal activity on the deep fungal, has the advantages of high efficiency, low toxicity, broad anti-fungal spectrum and the ...

一种网络游戏接入控制与计费方法

The method includes following steps: by-pass audio monitor is connected between LNS and game server cluster network; game users sends request to game server to build TCP; analyzing source IP address, target IP address and target port of the connection by using by-pass audio monitor; based on established control strategy, by-pass audio monitor carries out control; clocking and charging are summarized for built TCP by using audio monitor. The invention is suitable for diversified users to log on network through access modes. Authorization function can be added to game channel with no inference on users to play game normally.

N-acetylneuraminic acid compounds, pharmaceutical composition, preparation method and uses thereof

Method of on-line thread feeding and furnace protecting of ironmaking blast furnace and thread feeding device thereof

The invention provides a wire-feeding and furnace protection method of blast furnaces and the wire-feeding device. The purpose is to solve the following problems: conventionally, the Ti-containing furnace protection materials are added into the furnace together with the furnace materials through the top of the furnace. The application of Ti-containing powders will have significant impact on the production system of the furnace. At the same time, the Ti-containing materials will decrease the output of the furnace. In addition, the titanium oxide of the Ti-containing materials is uniformly mixed in the entire slag so that the titanium oxide density in the slag is lowered significantly. The key points of the invention are described in the followings: a wire-feeding device is connected with the coal-spraying mouth of the furnace blast blowpipe. The furnace protection material cored wires are sent to the furnace along the cored wire access of the wire-feeding device. The port through which the ...

Vision feedback control method based on wavelet nerve network

Self-adaptive particle filter-based robot vision servo control method

The invention discloses a self-adaptive particle filter-based robot vision servo control method which belongs to the technical field of computer artificial intelligence. The method comprises the following steps of: providing an expected target image characteristic and corresponding robot joint angle according to practical demand; then shooting the image and reading the robot joint angle at the moment; calculating the practical image characteristic of an object according to the image; calculating image characteristic deviation and transformation; if image characteristic deviation is zero, indicating that a robot arrives in the preset position and finishing the control process; otherwise, obtaining an image jacobian matrix; and finally, obtaining an estimating value of joint angle variation according to the obtained image jacobian matrix and image characteristic transformation. The estimating value of joint angle variation is input into a robot controller, and the controller controls and ...

Method for desilication of concentrate through reverse flotation for bauxite

The present invention relates to a predesilicification method of reverse floatation concentrate in the process of producing alumina by adopting reverse floatation concentrate. It is characterized by that the raw material for preparing green ore pulp is reverse floatation concentrate obtained by utilizing low-grade bauxite through reverse floatation desilicification process, the alumina-silica ratio in the reverse floatation concretrate is 8-15, and in the green ore pulp the reverse floatation concentrate, circulating alkali liquor and lime milk are added, and in the predesilicification tank the predesilicification can be made for 6-12 hr, at 90-110 deg.c so as to obtain the predesilicified ore pulp whose predesilicification rate is greater than 400.

Prevention and treatment medicament for plant diseases and insect pests of walnut trees and preparation method of prevention and treatment medicament

The invention relates to a prevention and treatment medicament for plant diseases and insect pests of walnut trees. The prevention and treatment medicament comprises gingko testa, common monkshood mother roots, rhizoma rohdeae japonicae, mexican tea herb, japanese flowering fern rhizome, root-bark of tree peony, cercis chinensis bunge barks, crotons, black false hellebores, rangooncreeper fruits and cloves. According to the prevention and treatment medicament, all the components are weighed and are decocted with water respectively; all extraction solutions are combined and are subjected to alcohol extraction with ethanol; and sediment is filtered to prepare a finished product. After water boiling and alcohol precipitation treatment, all effective insecticidal components of the components are extracted and are matched, so that diseases including rots, cankers and the like and insect pests including small llatheaded borers, batocera horsfieldi, drosicha corpulenta, cicadella viridis and the ...

Method of reverse flotation for preparing alumina from concentrate of beauxite

The method for producing alumina by adopting reverse floatation bauxite concentrate is characterized by that: a. using reverse floatation concentrate, lime milk and alkali liquor to prepare green ore pulp; b. preheating ore pulp to 220 deg.C, making desilicification and titanium-removing reaction, then more heating to 260-280 deg.C, making insulation resolution for 30-90 min, in the insulation tank, c. crystal seed decomposition adopts one-stage method including high-temp. agglomeration, low-temp, growing up and intermediate cooling process to make crystal seed decomposition to produce alumina; and d. making settlement and separation of red mud.

Method for storing and managing dynamic data

The invention discloses a method for storing and managing dynamic data, which relates to real-time storage and management of a large number of dynamic data and belongs to the field of data storage and information processing. Aiming at the problems existing in the aspects of integrity and real-time property for the single use of a database or a file container, the invention provides a vector container. The data are stored in the vector container and the file container respectively. The vector container mainly stores current data, and the volume of the vector container changes dynamically so as to ensure the real-time property of data processing and result display. A plurality of files are used for storing original data so as to ensure the integrity of data storage and the timeliness and the accuracy of history playback. The method for storing and managing a large number of the dynamic data not only can ensure the integrity of the data, but also can ensure the real-time property of the data ...

High-yield culture method of Thai Bink No.3 earthworm

The invention discloses a high-yield culture method of Thai Bink No.3 earthworm, which comprises the following steps that: earthworms are put inside a culture base stock, the earthworms and the culture base stock are completely separated from each other every 15 to 20 days, and the earthworm cocoon is put in the culture base stock; new culture base stock is added, so the earthworms continue to lay eggs, and the nutrition liquid is continuously added; and all earthworm cocoons are discharged at a heat-preservation place to be incubated, the moisture content in the culture base stock accounts for 55 to 75 percent (weight), and young earthworms which are incubated from the earthworm cocoons are separated to culture every 8 to 12 days. The high-yield culture method has the advantages that the breeding speed of the earthworm is fast, the pH value resistance range of the earthworm is large, the disease resistance is strong, and the yield is high.

Ecologic residential house building module

The invention discloses an ecologic residential house building module. The module comprises a frame, and is characterized in that an insulation plate, a support skeleton, a cushion plate, an extrusion molding plate and a floor are laid on the bottom layer of the frame from bottom to top to form a house body ground; waterproof insulation gum is coated on the bottom surface of the insulation plate; an insulation plate, a cushion plate, a roof support skeleton and an indoor decoration plate are laid on the top surface of the frame from bottom to top to form a roof; waterproof insulation gum is coated on the top surface of the insulation plate; or a triangular skeleton is arranged at the top of the frame; a color plate is laid on the triangular skeleton; a solar power generation plate is arranged on the color plate at the sunny side of a house body; and the triangular skeleton, the color plate and the solar power generation plate form the roof. The ecologic residential house building module ...

Method for preparing hot pressed balls of iron ore concentrate and powdered coal

Method for intensifying Bayer method seed-distribution

Aluminum electrolysis carbon anode oxidation coating and coating method thereof

The invention relates to an oxidation resistant coating for aluminum electrolytic carbon anode and a coating method thereof. The method is characterized in that the surface of the aluminum electrolytic carbon anode is provided with an anti-oxidation coating formed by dried and mixed coat which is sprayed on the surface of the electrode, wherein the mixed coat comprises the following compositions in weight percentage: 1 to 25 percent of bisphenol A-type waterborne epoxy resin, 0.1 to 16 percent of boron carbide, 2 to 13 percent of boric acid and/or boric oxide, 15 to 50 percent of alumina, 0 to 20 percent of pseudo-boehmite, 10 to 30 percent of alumina sol, 0.1 to 0.3 percent of foam suppressor, and the balance being water. The coating and the method adopt an alumina-based gradient boron carbide oxidation resistant coating with a multilayer structure, and effectively blocks the contact of air and CO2 with carbon anode carbon, thereby avoiding or reducing excessive consumption of the carbon ...

Soil DNA sample preparation kit and preparation method thereof

The invention discloses a soil DNA sample preparation reagent box and a manufacturing method, the reagent box comprises a box body and a baffle board, a reagent bottle A which is filled with solution I, a reagent bottle B which is filled with solution II, a reagent bottle C which is filled with solution III, a reagent bottle D which is filled with solution IV, a reagent bottle E which is filled with suspension liquid, a centrifuge tube F which is filled with acid cleaning glass bead, a mini filter G and a PCR(chain type polyase reaction) pipe H. A reagent box which is designed through the technical proposal of the invention has the advantages of simple employment and stable result, which can effectively save time and cost of users.

Data processing method and device, electronic equipment and storage medium

The invention provides a data processing method and device, electronic equipment and a storage medium, and relates to the technical field of cloud computing, the method comprises the following steps: creating a new function instance under the condition that the concurrency number of an existing function instance processing service request exceeds a concurrency threshold and does not exceed the concurrency degree of a pre-configured function instance; the concurrent threshold is dynamically changed according to the service operation state information; and under the condition that the concurrency number exceeds the concurrency degree of the function instance, starting a new function instance, and processing the received service request. In the embodiment, when the concurrency number of the service request processed by the existing function instance exceeds the concurrency threshold value, the new function instance is created, so that the time delay caused by cold start of the function instance ...

Method and device for removing image motion blur based on GAN and medium

The embodiment of the invention discloses a GAN-based method and device for removing image motion blur, and a medium. The method comprises the steps that a training set composed of a plurality of blurred images and corresponding clear images is acquired, and the blurred images comprise non-uniform motion blurred images; training a generator and a discriminator of a GAN model based on the training set, so that features obtained after a blurred image passes through the generator and the discriminator tend to be consistent with features obtained after a corresponding clear image passes through the discriminator; and extracting a trained generator from the trained GAN model, and performing deblurring on an image needing to be deblurred by using the trained generator. According to the embodiment, non-uniform motion blur in the image is removed.

Early warning method for abnormal operation of aluminum electrolysis cell

The embodiment of the invention provides an early warning method for abnormal operation of an aluminum electrolysis cell, which is applied to a roasting stage and comprises the following steps: in the roasting stage, acquiring a voltage value of a target electrolysis cell according to a preset time interval; determining an early warning analysis parameter according to each obtained voltage value, wherein the early warning analysis parameter is a parameter reflecting the change condition of the voltage value; determining whether the target electrolytic cell runs abnormally or not based on the early warning analysis parameters; and if the target electrolytic cell runs abnormally, outputting an alarm signal. According to the technical scheme provided by the embodiment of the invention, the operation state of the aluminum electrolysis cell in the roasting stage can be accurately monitored, so that abnormal conditions occurring in the roasting stage can be found in time, related technicians ...

Method and system for determining running state of electrolytic cell

The embodiment of the invention provides a method and system for determining the running state of an electrolytic bath, and the method comprises the steps: obtaining the running parameters and the reference running state of a target electrolytic bath, and the reference running state is the running state, counted by an electrolytic bath control system, of the target electrolytic bath; the theoretical operation state of the target electrolytic cell is determined according to the operation parameters; and the theoretical operation state is verified based on the reference operation state, and the current operation state of the target electrolytic cell is obtained. According to the technical scheme provided by the embodiment of the invention, the current running state of each series of electrolytic cells can be automatically and accurately determined in time, so that the manual operation is reduced, and the statistical accuracy of the running state data of the electrolytic cells is improved.

Difference method-based indoor video monitoring and alarming method

The invention discloses a difference method-based indoor video monitoring and alarming method, which belongs to the technical field of security guard and monitoring. The method comprises the following steps: firstly, acquiring an image in a normal state as a background image; shooting the images at a certain time interval and calculating an absolute value of a difference between pixel values of corresponding points in each image and the background image to obtain a difference image; scanning each pixel point of the difference image, if the pixel value of some a pixel point is greater than 0, determining the pixel value at the pixel point is remarkably changed with respect to the pixel value of the corresponding point in the background image, if the total number n of the changed pixel points is not less than a preset threshold K, determining an abnormity exists indoors at the time, recording pictures, storing video in a monitoring computer and sending alarming information to a user; otherwise ...

Method for testing toxicity of environmental estrogen on whitebait embryonic development

The invention discloses a method for testing toxicity of environmental estrogen on whitebait embryonic development. The method of the invention utilizes the sensitivity of embryo to the simulation of environmental pollutant or chemical matter to perform a test under semi-static state on whitebait embryo which is exposed in standard diluted aqueous solution of subject having a series of concentrations. The test lasts about 30 days, begins as exposing a live embryo at the blastula stage in the aqueous solution of subject, and ends with hatching all embryos in a control group and an exposed group. The toxicity endpoint contains death, monstrosity and delayed hatching. The method comprises the steps of confirming the toxicity of the subject on the whitebait embryonic development by observing the toxicity endpoint of the exposed group and comparing with the control group; researching on the influence of two natural estrogens E2 and EE2 on the whitebait embryo-yolk sac stage so as to confirm ...

Vision feedback control method based on wavelet nerve network

Comprehensive experiment system for adsorbing and desorbing VOCs gas by using activated carbon

The invention discloses a comprehensive experiment system for adsorption and desorption of VOCs gas by activated carbon, which comprises a water vapor generator, a VOCs gas source tank, a nitrogen tank, a mixing buffer tank, an adsorption box, a gas chromatograph, a VOCs gas storage and collection tank, a quantitative gas pump, a flowmeter, a bidirectional gas pump, an air dryer and a stop valve, and belongs to the technical field of oil and gas well downhole operation. The device is suitable for testing and researching related parameters such as efficiency of adsorbing and desorbing the VOCs gas by the activated carbon. According to the invention, the adsorption experiment and desorption experiment of the active carbon on the VOCs gas can be carried out, and the influence of the active carbon type, the working temperature of the adsorption box, and the VOCs gas humidity and flow velocity on the adsorption and desorption efficiency can be researched respectively. And the cooling time of ...

Substituted-amino dithiocarbamic acid ester matrine derivative and preparation method and application

The invention relates to a substituted-amino dithiocarbamic acid ester matrine derivative. Please see the general molecular formula of the matrine derivative in the specifications, wherein, the R is selected from fat amino or a cyclic amine group or benzyl. The invention further provides salts capable of being accepted by the matrine derivative in pharmacy, and the preparation method and application of the matrine derivative. According to preliminary cell tests, the substituted-amino dithiocarbamic acid ester matrine derivative and the salts capable of being accepted by the same in pharmacy have the advantages of being capable of remarkably inhibiting the human hepatocarcinoma cell line Hun-7, having the remarkable anti-hepatoma activity, having great potential in preparation of anti-hepatic fibrosis and anti-hepatoma drugs, being low in toxicity, and being capable of being used for preparing the drugs for treating relative inflammation diseases involving cell factors and the nuclear transcription ...

Method of reverse flotation for preparing alumina from concentrate of beauxite

The method for producing alumina by adopting reverse floatation bauxite concentrate is characterized by that: a. using reverse floatation concentrate, lime milk and alkali liquor to prepare green orepulp; b. preheating ore pulp to 220 deg.C, making desilicification and titanium-removing reaction, then more heating to 260-280 deg.C, making insulation resolution for 30-90 min, in the insulation tank, c. crystal seed decomposition adopts one-stage method including high-temp. agglomeration, low-temp, growing up and intermediate cooling process to make crystal seed decomposition to produce alumina; and d. making settlement and separation of red mud.

Method for extracting iron from poor mixed hematite

The invention relates to a method for extracting iron from low-grade complicated hematite ore, belonging to the field of minerals processing technology. The method comprises the following steps: crushing: crushing the low-grade complicated hematite ore and coal to same granularity, the largest granularity being 1mm to 5mm; mixing: uniformly mixing the coal powder and ore powder in a proportion of (10 to 40): 100; reducing: putting the mixed coal powder and ore powder into a reduction furnace, and then heating to 1200 DEG C to 1400 DEG C, holding this temperature for 30 to 90 minutes; cooling: cooling the ore powder to a temperature below 600 DEG C, getting out the ore powder from the reduction furnace and cooling to normal temperature; magnetic separating: after the above material being cooled, eliminating the excessive protection coal from protective coal seam by a magnetic extractor, and then recycling and reusing, low-grade concentrated ore being acquired after the magnetic separating ...

Molecular specific marker primer for Sakura variety 'C.serrulata Kanzan' and detection method thereof

The invention relates to a molecular specific marker primer for Sakura variety 'C.serrulata Kanzan' with high specificity, and a method for rapidly identifying the Sakura variety 'C.serrulata Kanzan'. The primer comprises the following sequences: a forward primer: 5'-TGAGTCCAAACCGGACCAAGTT-3', and a reverse primer: 5'-GACTGCGTACGAATTTGAAAAGCT-3'. The molecular specific marker primer disclosed by the invention can perform rapid preliminary identification on the Sakura variety 'C.serrulata Kanzan', and the method is simple, rapid and accurate and is a molecular method which cannot be replaced for identifying the apparent characteristics of the Sakura varieties.

PRC1 INHIBITORS AND METHODS OF TREATMENT THEREWITH

Provided herein are small molecule inhibitors of Polycomb Repressive Complex 1 (PRC1) activity, and methods of use thereof for the treatment of disease, including leukemia and other cancers, as well as other diseases dependent on the activity of PRC1. 2. (canceled)3. The PRC1 inhibitor of claim 1 , comprising a pyrrole claim 1 , furan claim 1 , or thiophene ring displaying the substituents of one or more of the compounds of Table A claim 1 , in any suitable combination.4. The PRC1 inhibitor of claim 3 , comprising a compound of Table A.6. The PRC1 inhibitor of claim 5 , wherein A claim 5 , A′ claim 5 , E claim 5 , and E′ are independently selected from the rings of Table 1.9. The PRC1 inhibitor of comprising any combination of substituents depicted on the compounds of Table A.10. The PRC1 inhibitor of claim 7 , wherein the compound is selected from the compounds of Table A.11. A pharmaceutical composition comprising the PRC1 inhibitor of and a pharmaceutically acceptable carrier.12. The pharmaceutical composition of claim 11 , wherein the pharmaceutical composition is formulated for oral administration.13. The pharmaceutical composition of claim 11 , wherein the pharmaceutical composition is formulated for injection.14. A method of inhibiting PRC1 with an effective amount of a pharmaceutical composition of .15. The method of claim 14 , wherein PRC1 activity is inhibited by binding of the compound or pharmaceutical composition to PRC1.16. A method of treating a subject comprising administering to the subject a pharmaceutical composition of .17. (canceled)18. The method of claim 16 , wherein the subject suffers from cancer.19. The method of claim 18 , wherein the cancer comprises leukemia claim 18 , hematologic malignancy claim 18 , solid tumor cancer claim 18 , breast cancer claim 18 , prostate cancer claim 18 , colon cancer claim 18 , pancreatic cancer claim 18 , ovarian cancer claim 18 , liver cancer or thyroid cancer.20. The method of claim 19 , wherein the ...

Molecular specific marker primer and detection method for Sakura variety 'Cerasus yedoensis Sakuyahime'

The invention relates to a molecular specific marker primer with high specificity for Sakura variety 'Cerasus yedoensis Sakuyahime' and a method capable of rapidly identifying the Sakura variety 'Cerasus yedoensis Sakuyahime'. The primer has the following sequences: an upstream primer: 5'-TGAGTCCAAACCGGACCGAGAAG-3', and a downstream primer: 5'-GACTGCGTACGAATTGACGGGAAT-3'. The molecular specific marker primer disclosed by the invention can realize rapid preliminary identification of the Sakura variety 'Cerasus yedoensis Sakuyahime', and the method is simple, rapid and accurate and is a molecular method which cannot be replaced for identifying apparent characteristics of the Sakura variety.

Inertial electrode low-temperature aluminium electrolytic cell

The invention discloses an inertial electrode low-temperature aluminium electrolytic cell comprising a electrolytic cell body, a metallic ceramic inertial anode, a wettable cathode and a low-temperature electrolyte, wherein, the wettable cathode is arranged at the bottom of the electrolytic cell body; the low-temperature electrolyte is arranged in the electrolytic cell body; the metallic ceramic inertial anode is arranged at the upper part of the electrolytic cell body, and end part of the metallic ceramic inertial anode extends into the low-temperature electrolyte; the metallic ceramic inertial anode is composed of at least two groups of metal ceramic inertial anode sets; each metallic ceramic inertial anode set is composed of at least two metallic ceramic inertial anode monomers; the metallic ceramic inertial anode sets and the metal ceramic inertial anode monomers in the same metal ceramic inertial anode sets are both in electrical parallel connection. The inertial electrode low-temperature ...

Detecting Separator Lines in a Web Page

A system and method of detecting separator lines in a web page may include determining coordinates of visible web elements on a web page, generating an edge image of the web page based on the coordinates of the web elements, filtering edges belonging to non-separator line elements within the edge image, detecting horizontal lines within the edge image, detecting vertical lines within the edge image, and filtering short lines within the edge image. A system for detecting separator lines in a web page may include a memory device, and a processor communicatively coupled to the memory, in which the processor determines coordinates of visible web elements on a web page, generates an edge image of the web page based on the coordinates of the web elements, filters edges belonging to non-separator line elements within the edge image, detects horizontal lines within the edge image, detects vertical lines within the edge image, and filters short lines within the edge image. 1. A method performed by a physical computing device comprising at least one processor for detecting separator lines in a web page comprising:determining, with the computing system, coordinates of visible web elements on a web page;generating, with the computing system, an edge image of the web page based on the coordinates of the web elements;filtering, with the computing system, edges belonging to non-separator line elements within the edge image;detecting, with the computing system, horizontal lines within the edge image;detecting, with the computing system, vertical lines within the edge image; andfiltering, with the computing system short lines within the edge image to provide an indication of the separator lines.2. The method of claim 1 , in which determining coordinates of visible web elements on a web page comprises:querying each of a plurality of text nodes of a data structure representing the web page;wrapping each of the plurality of ext nodes in a pair of mark-up language tags;obtaining the co- ...

PRC1 inhibitors and methods of treatment therewith

Provided herein are small molecule inhibitors of Polycomb Repressive Complex 1 (PRC1) activity, and methods of use thereof for the treatment of disease, including leukemia and other cancers, as well as other diseases dependent on the activity of PRC1.

Prc1 inhibitors and methods of treatment therewith

Prc1 inhibitors and prc1 inhibitors for use in methods of treatment therewith