24-01-2019 дата публикации
Номер: US20190022044A1
Принадлежит:
The present disclosure provides new salts of 5-aminolevulinic acid (5-ALA) and new salts of 5-ALA esters, their preparation, formulation and use as photosensitizing agents in photodynamic therapy, diagnosis and cosmetic cares. 2. The salt of claim 1 , wherein R is selected from the group consisting of hydrogen claim 1 , methyl claim 1 , ethyl claim 1 , propyl claim 1 , butyl claim 1 , pentyl claim 1 , hexyl claim 1 , sec-propyl claim 1 , sec-butyl claim 1 , tert-butyl claim 1 , sec-pentyl claim 1 , sec-hexyl claim 1 , cyclopropyl claim 1 , cyclobutyl claim 1 , cyclopentyl claim 1 , cyclohexyl claim 1 , benzyl claim 1 , 2-methyl benzyl claim 1 , 4-methyl benzyl claim 1 , 4-chloro-benzyl claim 1 , 4-chloro-benzyl claim 1 , 2-nitro-benzyl claim 1 , 4-nitro-benzyl claim 1 , 2-isopropyl benzyl claim 1 , 4-isopropyl benzyl claim 1 , 4-fluoro-benzyl claim 1 , and 4-fluoro-benzyl.34-. (canceled)5. The salt of claim 1 , wherein Rand Rare independently selected from the group consisting of hydrogen and Calkyl.6. The salt of claim 1 , wherein X is selected from the group consisting of —CHCl claim 1 , and —CCl.7. The salt of claim 1 , wherein X is —CCl.8. A salt of selected from the group consisting of 5-aminolevulinic acid 2 claim 1 ,2 claim 1 ,2-trichloroacetate claim 1 , methyl 5-aminolevulinate 2 claim 1 ,2 claim 1 ,2-trichloroacetate claim 1 , hexyl 5-aminolevulinate 2 claim 1 ,2 claim 1 ,2-trichloroacetate claim 1 , benzyl 5-aminolevulinate 2 claim 1 ,2 claim 1 ,2-trichloroacetate claim 1 , and methylbenzy 5-aminolevulinate 2 claim 1 ,2 claim 1 ,2-trichloroacetate.9. A composition comprising the salt of and at least one of a pharmaceutically acceptable carrier and a cosmetically acceptable carrier.1012-. (canceled)13. The composition of claim 1 , wherein the salt of is a first photosensitizing agent claim 1 , and wherein the composition comprises a second photosensitizing agent.14. The composition of claim 13 , wherein the second photosensitizing agent is selected from ...
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