24-12-2015 дата публикации
Номер: US20150366836A1
Принадлежит:
The present invention is related to a method and pharmaceutical composition for treating colorectal cancer. The pharmaceutical composition comprises an effective amount of 16-hydroxy-cleroda-3,13-dine-15,16-olide as active ingredient, and a pharmaceutically acceptable carrier. The present method and pharmaceutical composition provides good efficacy in treating colorectal cancer. The present invention also establishes an animal model, which provides a better drug screening platform for the research. 1. A pharmaceutical composition for colorectal cancer treatment , comprising:an effective amount of 16-hydroxy-cleroda-3,13-dine-15,16-olide; anda pharmaceutically acceptable carrier.2. The composition of claim 1 , wherein said effective amount is 0.6 to 6.5 mg/kg body weight.3. The composition of claim 1 , comprising 0.5 to 10 μM of said 16-hydroxy-cleroda-3 claim 1 ,13-dine-15 claim 1 ,16-olide.4. The composition of claim 1 , wherein said pharmaceutically acceptable carrier is water claim 1 , phosphate buffered saline claim 1 , alcohol claim 1 , glycerol claim 1 , chitosan claim 1 , alginate claim 1 , chondroitin claim 1 , Vitamin E claim 1 , mineral oil claim 1 , dimethyl sulfoxide (DMSO) claim 1 , or a combination thereof.5. The composition of claim 1 , wherein an administration route of said composition is via oral administration claim 1 , intravenous injection claim 1 , intrathecal injection claim 1 , intraperitoneal injection claim 1 , or a combination thereof.6. A method for treating a colorectal cancer claim 1 , comprising:administrating an object in need an effective amount of 16-hydroxy-cleroda-3,13-dine-15,16-olide.7. The method of claim 6 , wherein said effective amount is 0.6 to 6.5 mg/kg body weight.8. The method of claim 6 , wherein said administrating is via oral administration claim 6 , intravenous injection claim 6 , intrathecal injection claim 6 , intraperitoneal injection claim 6 , or a combination thereof.9. The method of claim 6 , wherein said 16- ...
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