ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 1. An electrochemical continuous glucose sensor configured for implantation in a host , the glucose sensor comprising:an electrode configured to measure a signal indicative of a glucose concentration of a host, wherein the signal comprises a glucose-related component and a non-glucose related component; anda membrane covering at least a portion of the electrode, wherein the membrane is configured to reduce passage of an interfering species therethrough, whereby the non-glucose-related component of the signal is less than about 20% of the signal over a period of at least one day;wherein the glucose sensor has a sensitivity to glucose of from about 25 pA/mg/dL to about 500 pA/mg/dL.2. The glucose sensor of claim 1 , wherein the interfering species has an oxidation potential that overlaps with an oxidation potential of a measured species indicative of the concentration of the analyte.3. The glucose sensor of claim 1 , wherein the measured species is a product of an enzymatic reaction between glucose and an enzyme and is measured by the electrode.4. The glucose sensor of claim 1 , wherein the membrane comprises a silicone-containing polymer.5. The glucose sensor of claim 4 , wherein the silicone-containing polymer is a polysiloxanes.6. The glucose sensor of claim 4 , wherein the silicone-containing polymer is a polycarbosiloxane.7. The glucose sensor of wherein the silicone-containing polymer is a copolymer comprising a silicone segment and a polyurethane segment.8. The glucose sensor of claim 1 , wherein the membrane comprises a fluorocarbon-based material.9. The glucose sensor of claim 1 , wherein the non-glucose-related component ...

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 126-. (canceled)27. A transcutaneous electrochemical glucose sensor configured for implantation in a host , the transcutaneous electrochemical glucose sensor comprising:a first portion configured to remain outside a body of the host during sensor use; and a working electrode comprising a plurality of sensing regions; and', 'a reference electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor., 'a second portion configured to be inserted inside the body of the host during sensor use, wherein the second portion comprises28. The transcutaneous electrochemical glucose sensor of claim 27 , wherein the membrane comprises a layer configured to control a diffusion of glucose therethrough.29. The transcutaneous electrochemical glucose sensor of claim 27 , wherein the layer comprises polyurethane.30. The transcutaneous electrochemical glucose sensor of claim 27 , wherein the transcutaneous electrochemical glucose sensor has a planar shape.31. The transcutaneous electrochemical glucose sensor of claim 27 , wherein the reference electrode further comprises silver and silver chloride.32. The transcutaneous electrochemical glucose sensor of claim 27 , further comprising a counter electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor.33. The transcutaneous electrochemical sensor of claim 27 , wherein each of the plurality of sensing regions comprises a membrane.34. The transcutaneous electrochemical sensor of claim 33 , wherein the membrane comprises an enzyme.35. The transcutaneous electrochemical sensor of claim 33 , wherein the ...

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

DEVICES, SYSTEMS, AND METHODS TO COMPENSATE FOR EFFECTS OF TEMPERATURE ON IMPLANTABLE SENSORS

Systems and methods for compensating for effects of temperature on implantable sensors are provided. In some embodiments, systems and methods are provided for measuring a temperature to determine a change in temperature in a sensor environment. In certain embodiments, a temperature compensation factor is determined based on a change in temperature of the sensor environment. The temperature compensation factor can be used in processing raw data of an analyte signal to report a more accurate analyte concentration.

PARTICLE-CONTAINING MEMBRANE AND PARTICULATE ELECTRODE FOR ANALYTE SENSORS

Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 120-. (canceled)21. A system for continuous in vivo measurement of glucose in a host , the system comprising: a non-conductive material,', 'conductive particles distributed within the non-conductive material, wherein each of the conductive particles has a three-dimensional electroactive surface, wherein the conductive particles comprise silver and silver chloride particles, and', 'a biocompatible membrane located over at least a portion of the electrode; and', 'sensor electronics operably connected to the continuous glucose sensor, wherein the sensor electronics are configured to process the signal from the continuous glucose sensor., 'a continuous glucose sensor configured for implantation in a host and configured to measure in vivo a signal indicative of glucose concentration, wherein the continuous glucose sensor comprises an electrode, wherein the electrode comprises22. The system of claim 21 , wherein the electrode comprises a plurality of sensing elements claim 21 , wherein the sensor electronics are configured to determine the glucose concentration by averaging or integrating signals from the plurality of sensing elements.23. The system of claim 22 , wherein the sensing elements are spaced along a substantial length of an in vivo portion of the continuous glucose sensor.24. system of claim 22 , wherein the plurality of sensing elements comprise more than two electroactive surfaces.25. The system of claim 22 , wherein the plurality of sensing elements comprise more than three electroactive surfaces.26. The system of claim 22 , wherein the plurality of sensing elements are spaced apart within a diffusion distance of a measured glucose.27. The system of claim 21 , wherein ...

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 120-. (canceled)21. A transcutaneous electrochemical glucose sensor configured for implantation in a host , the transcutaneous electrochemical glucose sensor comprising:a first portion configured to remain outside a body of the host during sensor use, wherein the first portion is configured to operably connect with sensor electronics; and a planar substrate;', 'a working electrode disposed over at least a portion of the planar substrate;', 'a membrane layer disposed over at least a portion of the working electrode; and', 'a reference electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor,, 'a second portion configured to be inserted inside the body of the host during sensor use, wherein the second portion comprises22. The transcutaneous electrochemical glucose sensor of claim 21 , wherein the membrane layer is configured to control a diffusion of glucose therethrough.23. The transcutaneous electrochemical glucose sensor of claim 21 , wherein the membrane layer comprises polyurethane.24. The transcutaneous electrochemical glucose sensor of claim 21 , wherein the transcutaneous electrochemical glucose sensor has a planar shape.25. The transcutaneous electrochemical glucose sensor of claim 21 , wherein the reference electrode comprises silver and silver chloride.26. The transcutaneous electrochemical glucose sensor of claim 21 , further comprising a counter electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby ...

Multiple electrode system for a continuous analyte sensor, and related methods

In one embodiment, a continuous analyte sensor having more than one working electrode, and configured to reduce or eliminate crosstalk between the working electrodes. In another embodiment, a continuous analyte sensor having more than one working electrode, and configured so that a membrane system has equal thicknesses over each of the electrodes, despite having differing numbers of layers over each of the electrodes. In another embodiment, a configuration for connecting a continuous analyte sensor to sensor electronics. In another embodiment, methods for forming precise windows in an insulator material on a multi-electrode assembly. In another embodiment, a contact assembly for a continuous analyte sensor having more than one working electrode.

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

SYSTEMS AND METHODS FOR PATIENT MONITORING USING AN HCP-SPECIFIC DEVICE

Systems and methods disclosed provide ways for Health Care Professionals (HCPs) to be involved in initial patient system set up so that the data received is truly transformative, such that the patient not just understands what all the various numbers mean but also how the data can be used. For example, in one implementation, a CGM device is configured for use by a HCP, and includes a housing and a circuit configured to receive a signal from a transmitter coupled to an indwelling glucose sensor. A calibration module converts the received signal into clinical units. A user interface is provided that is configured to display a measured glucose concentration in the clinical units. The user interface is further configured to receive input data about a patient level, where the input data about the patient level causes the device to operate in a mode appropriate to the patient level.

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 1. An analyte monitoring system , the system comprising: a first wire comprising a working electrode configured to generate a signal indicative of an analyte concentration;', 'a second wire comprising a reference electrode; and', 'a third wire comprising a counter electrode; and, "an electrochemical sensor configured to measure a level of an analyte in a biological sample from a patient, wherein the biological sample is a tear, wherein the sensor is configured to be fastened to a portion of a patient's body, wherein the sensor is configured to be powered by inductive coupling, wherein the sensor comprises:"}sensor electronics configured to operatively connect to the sensor, wherein the sensor electronics are configured to process data obtained from the sensor.2. The system of claim 1 , wherein the first wire claim 1 , second wire claim 1 , and third wire are formed of metal.3. The system of claim 1 , wherein the first wire comprises platinum.4. The system of claim 1 , wherein the second wire comprises silver/silver chloride.5. The system of claim 1 , wherein the third wire comprises platinum.6. The system of claim 1 , wherein at least one of the first wire claim 1 , second wire claim 1 , or third wire is in a coiled configuration during sensor use.7. The system of claim 1 , wherein the sensor further comprises a membrane comprising an enzyme configured to react with the analyte claim 1 , wherein at least a portion of the working electrode is covered by the membrane.8. The system of claim 7 , wherein the enzyme is configured to react with glucose to produce hydrogen peroxide.9. The system of claim 8 , wherein the working electrode is configured to oxidize hydrogen peroxide to generate the signal indicative of the analyte concentration.10. The ...

Analyte sensor

Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system 180 is provided having a first working electrode 150 comprising a first sensor element 102 and a second working electrode 160 comprising ...

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

DEVICES USED IN CONNECTION WITH CONTINUOUS ANALYTE MONITORING THAT PROVIDE THE USER WITH ONE OR MORE NOTIFICATIONS, AND RELATED METHODS

Devices and methods for providing a user with alerts are provided. The alerts may take different forms, such as an output to a display, a speaker, a vibration module, a shock module, etc. The alerts provide the user with sufficient information to take appropriate action, but the devices may be of limited functionality to enhance their compactness, discreetness, wearability, etc., while also lowering their cost to manufacture. 1. A wearable device for providing an alert to a user regarding the user's blood glucose value , the device comprising:a communication module for receiving a signal from a transmitter of a continuous glucose monitoring device; andan alert interface configured to provide a first alert when the wearer's blood glucose value is within a predetermined range, and a second alert that the wearer's blood glucose value is outside the predetermined range.2. The device of claim 1 , further comprising a band configured to be worn about a wrist of a wearer claim 1 , wherein the communication module and the alert interface are incorporated into the band.3. The device of claim 2 , wherein the band comprises a closed loop having no endpoints.4. The device of claim 3 , wherein the band is constructed of a resilient material.5. The device of claim 1 , wherein the alert interface comprises a display including at least one of a liquid crystal display claim 1 , one or more light-emitting diodes claim 1 , one or more organic light-emitting diodes claim 1 , an electronic paper display claim 1 , a color- or pattern-changing material claim 1 , or a text display.6. The device of claim 1 , wherein the communication module is configured to relay the signal received from the transmitter to another electronic device.7. The device of claim 6 , wherein the communication module is configured to store data received from the transmitter and relay the data to the other electronic device at regular intervals.8. The device of claim 7 , wherein the device is configured to process or ...

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 112-. (canceled)13. A system for measuring an analyte concentration in a host , the system comprising:a transcutaneous analyte sensor; andsensor electronics configured to operatively connect to the transcutaneous analyte sensor.14. A method for processing data from a transcutaneous glucose sensor , the method comprising:receiving sensor data from the transcutaneous analyte sensor after the transcutaneous analyte sensor is implanted in a host, wherein the sensor data is indicative of an analyte concentration in the host; andprocessing, using a processor, the sensor data received from the transcutaneous analyte sensor. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 16/674,610, filed Nov. 5, 2019, which is a continuation of U.S. application Ser. No. 16/392,521, filed Apr. 23, 2019, which is a continuation of U.S. application Ser. No. 14/590,483, filed Jan. 6, 2015, now U.S. Pat. No. 10,314,525, which is a continuation of U.S. application Ser. No. 13/909,962, filed Jun. 4, 2013, now U.S. Pat. No. 9,247,900, which is a continuation of U.S. application Ser. No. 11/360,262, filed Feb. 22, 2006, now U.S. Pat. No. 8,615,282. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification. The aforementioned application is incorporated by reference herein in its entirety, and is hereby expressly made a part of this specification.The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods ...

Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

ANALYTE SENSOR WITH INCREASED REFERENCE CAPACITY

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes an electrochemical sensor incorporating a silver/silver chloride reference electrode, wherein a capacity of the reference electrode is controlled.

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 112-. (Canceled)13. A system for measuring an analyte concentration in a host , the system comprising:a transcutaneous analyte sensor; andsensor electronics configured to operatively connect to the transcutaneous analyte sensor.14. A method for processing data from a transcutaneous analyte sensor , the method comprising:receiving sensor data indicative of an analyte concentration in the host; andprocessing, using a processor, the sensor data. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 17/088,446, filed Nov. 3, 2020, which is a continuation of U.S. application Ser. No. 16/924,117, filed Jul. 8, 2020, now U.S. Pat. No. 10,918,315, which is a continuation of U.S. application Ser. No. 16/691,358, filed Nov. 21, 2019, now U.S. Pat. No. 10,709,362, which is a continuation of U.S. application Ser. No. 16/674,610, filed Nov. 5, 2019, now U.S. Pat. No. 10,722,152, which is a continuation of U.S. application Ser. No. 16/392,521, filed Apr. 23, 2019, which is a continuation of U.S. application Ser. No. 14/590,483, filed Jan. 6, 2015, now U.S. Pat. No. 10,314,525, which is a continuation of U.S. application Ser. No. 13/909,962, filed Jun. 4, 2013, now U.S. Pat. No. 9,247,900, which is a continuation of U.S. application Ser. No. 11/360,262, filed Feb. 22, 2006, now U.S. Pat. No. 8,615,282. U.S. patent application Ser. No. 17/088,446 is a continuation-in-part of U.S. application Ser. No. 16/133,469, filed Sep. 17, 2018, now abandoned, which is a continuation of U.S. application Ser. No. 15/686,650, filed Aug. 25, 2017, now abandoned, which is a continuation of U.S. application Ser. No. 14/ ...

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Systems and methods for securing a continuous analyte sensor to a host

Adhesive pad systems that provide longer lasting adherence of the mounting unit to the host's skin are provided. Some systems include a reinforcing overlay that at least partially covers the adhesive pad. The reinforcing overlay may be removable without disturbing the sensor so that the overlay may be replaceable.

ANALYTE SENSORS AND METHODS OF MANUFACTURING SAME

Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 120-. (canceled)21. A transcutaneous electrochemical glucose sensor configured for implantation in a host , the transcutaneous electrochemical glucose sensor comprising:a first portion configured to remain outside a body of the host during sensor use, wherein the first portion is configured to operably connect with sensor electronics; and a working electrode configured for use in measuring a signal indicative of a glucose concentration of the host;', 'a membrane covering at least a portion of the working electrode; and', 'a reference electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor., 'a second portion configured to be inserted inside the body of the host during sensor use, wherein the second portion comprises22. The transcutaneous electrochemical glucose sensor of claim 21 , wherein the membrane comprises a layer configured to control a diffusion of glucose therethrough.23. The transcutaneous electrochemical glucose sensor of claim 22 , wherein the layer comprises polyurethane.24. The transcutaneous electrochemical glucose sensor of claim 21 , wherein the transcutaneous electrochemical glucose sensor has a planar shape.25. The transcutaneous electrochemical glucose sensor of claim 21 , wherein the reference electrode comprises silver and silver chloride.26. The transcutaneous electrochemical glucose sensor of claim 21 , further comprising a counter electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby ...

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 112-. (canceled)13. A system for measuring an analyte concentration in a host , the system comprising:a transcutaneous analyte sensor; andsensor electronics configured to operatively connect to the transcutaneous analyte sensor.14. A method for processing data from a transcutaneous analyte sensor , the method comprising:receiving sensor data indicative of an analyte concentration in the host; andprocessing, using a processor, the sensor data. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 16/924,117, filed Jul. 8, 2020, which is a continuation of U.S. application Ser. No. 16/691,358, filed Nov. 21, 2019, now U.S. Pat. No. 10,709,362, which is a continuation of U.S. application Ser. No. 16/674,610, filed Nov. 5, 2019, now U.S. Pat. No. 10,722,152, which is a continuation of U.S. application Ser. No. 16/392,521, filed Apr. 23, 2019, which is a continuation of U.S. application Ser. No. 14/590,483, filed Jan. 6, 2015, now U.S. Pat. No. 10,314,525, which is a continuation of U.S. application Ser. No. 13/909,962, filed Jun. 4, 2013, now U.S. Pat. No. 9,247,900, which is a continuation of U.S. application Ser. No. 11/360,262, filed Feb. 22, 2006, now U.S. Pat. No. 8,615,282. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification. The aforementioned application is incorporated by reference herein in its entirety, and is hereby expressly made a part of this specification.The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, ...

MULTIPLE ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR, AND RELATED METHODS

In one embodiment, a continuous analyte sensor having more than one working electrode, and configured to reduce or eliminate crosstalk between the working electrodes. In another embodiment, a continuous analyte sensor having more than one working electrode, and configured so that a membrane system has equal thicknesses over each of the electrodes, despite having differing numbers of layers over each of the electrodes. In another embodiment, a configuration for connecting a continuous analyte sensor to sensor electronics. In another embodiment, methods for forming precise windows in an insulator material on a multi-electrode assembly. In another embodiment, a contact assembly for a continuous analyte sensor having more than one working electrode. 1. A continuous analyte sensor , comprising:a first working electrode;a second working electrode; anda membrane overlying at least a portion of the sensor, including the first and second working electrodes, the membrane being continuous, but for a first portion located between the first and second working electrodes that has properties that differ from properties of other portions of the membrane.2. The continuous analyte sensor of claim 1 , wherein at least one of the properties is permeability.3. The continuous analyte sensor of claim 2 , wherein the first portion is cross-linked.4. The continuous analyte sensor of claim 2 , wherein the other portions are cross-linked claim 2 , and the first portion is cross-linked by an amount different from the other portions.5. The continuous analyte sensor of claim 2 , wherein the first portion has a lower content of a hydrophilic species than the other portions.6. The continuous analyte sensor of claim 5 , wherein the hydrophilic species is removed by a secondary removal process claim 5 , a leaching process claim 5 , or a precipitation process involving heat claim 5 , pH claim 5 , or solvents.7. The continuous analyte sensor of claim 1 , wherein the first portion comprises a ...

ANALYTE SENSOR WITH INCREASED REFERENCE CAPACITY

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes an electrochemical sensor incorporating a silver/silver chloride reference electrode, wherein a capacity of the reference electrode is controlled.

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 112-. (canceled)13. A system for measuring an analyte concentration in a host , the system comprising:a transcutaneous analyte sensor; andsensor electronics configured to operatively connect to the transcutaneous analyte sensor.14. A method for processing data from a transcutaneous analyte sensor , the method comprising:receiving sensor data indicative of an analyte concentration in the host; andprocessing, using a processor, the sensor data. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 17/088,446, filed Nov. 3, 2020, which is a continuation of U.S. application Ser. No. 16/924,117, filed Jul. 8, 2020, now U.S. Pat. No. 10,918,315, which is a continuation of U.S. application Ser. No. 16/691,358, filed Nov. 21, 2019, now U.S. Pat. No. 10,709,362, which is a continuation of U.S. application Ser. No. 16/674,610, filed Nov. 5, 2019, now U.S. Pat. No. 10,722,152, which is a continuation of U.S. application Ser. No. 16/392,521, filed Apr. 23, 2019, which is a continuation of U.S. application Ser. No. 14/590,483, filed Jan. 6, 2015, now U.S. Pat. No. 10,314,525, which is a continuation of U.S. application Ser. No. 13/909,962, filed Jun. 4, 2013, now U.S. Pat. No. 9,247,900, which is a continuation of U.S. application Ser. No. 11/360,262, filed Feb. 22, 2006, now U.S. Pat. No. 8,615,282. U.S. patent application Ser. No. 17/088,446 is a continuation-in-part of U.S. application Ser. No. 16/133,469, filed Sep. 17, 2018, now abandoned, which is a continuation of U.S. application Ser. No. 15/686,650, filed Aug. 25, 2017, now abandoned, which is a continuation of U.S. application Ser. No. 14/ ...

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 112-. (canceled)13. A system for measuring an analyte concentration in a host , the system comprising:a transcutaneous analyte sensor; andsensor electronics configured to operatively connect to the transcutaneous analyte sensor.14. A method for processing data from a transcutaneous analyte sensor , the method comprising:receiving sensor data from the transcutaneous analyte sensor after the transcutaneous analyte sensor is implanted in a host, wherein the sensor data is indicative of an analyte concentration in the host; andprocessing, using a processor, the sensor data received from the transcutaneous analyte sensor. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 16/691,358, filed Nov. 21, 2019, which is a continuation of U.S. application Ser. No. 16/674,610, filed Nov. 5, 2019, which is a continuation of U.S. application Ser. No. 16/392,521, filed Apr. 23, 2019, which is a continuation of U.S. application Ser. No. 14/590,483, filed Jan. 6, 2015, now U.S. Pat. No. 10,314,525, which is a continuation of U.S. application Ser. No. 13/909,962, filed Jun. 4, 2013, now U.S. Pat. No. 9,247,900, which is a continuation of U.S. application Ser. No. 11/360,262, filed Feb. 22, 2006, now U.S. Pat. No. 8,615,282. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification. The aforementioned application is incorporated by reference herein in its entirety, and is hereby expressly made a part of this specification.The present invention relates generally to systems and methods for measuring an analyte ...

AUTOMATIC ANALYTE SENSOR CALIBRATION AND ERROR DETECTION

Systems and methods are provided that address the need to frequently calibrate analyte sensors, according to implementation. In more detail, systems and methods provide a preconnected analyte sensor system that physically combines an analyte sensor to measurement electronics during the manufacturing phase of the sensor and in some cases in subsequent life phases of the sensor, so as to allow an improved recognition of sensor environment over time to improve subsequent calibration of the sensor. 1. A method for self-calibration of an analyte sensor system that includes an analyte sensor operatively coupled to sensor electronics , comprising:applying a bias voltage with the sensor electronics to the analyte sensor to generate sensor data, the analyte sensor system having an initial characteristic metric determined at a first time;using the sensor electronics at a second time subsequent to the first time to determine a change to the initial characteristic sensitivity metric of the analyte sensor system based at least in part on one or more manufacturing and/or environmental parameters; andusing the sensor electronics to automatically calibrate, without user intervention, the analyte sensor system based at least in part on the determined change to the initial characteristic metric.2. The method of claim 1 , further comprising monitoring the one or more environmental parameters between the first time and second time.3. The method of claim 2 , wherein monitoring the one or more environmental parameters includes measuring an impedance of the analyte sensor by:applying a stimulus signal to the analyte sensor; measuring a signal response to the stimulus signal;calculating the impedance based on the signal response; anddetermining a value for the environmental parameter based on an established relationship between the impedance and the environmental parameter.4. The method of claim 2 , wherein the first time is subsequent to sensor fabrication and the second time is prior to ...

Analyte sensor

Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system 180 is provided having a first working electrode 150 comprising a first sensor element 102 and a second working electrode 160 comprising ...

AUTOMATIC ANALYTE SENSOR CALIBRATION AND ERROR DETECTION

Systems and methods are provided that address the need to frequently calibrate analyte sensors, according to implementation. In more detail, systems and methods provide a preconnected analyte sensor system that physically combines an analyte sensor to measurement electronics during the manufacturing phase of the sensor and in some cases in subsequent life phases of the sensor, so as to allow an improved recognition of sensor environment over time to improve subsequent calibration of the sensor. 1. An analyte sensor system comprising:a continuous analyte sensor operable to obtain measurements indicative of analyte levels in a body of a host; and (i) generating an actual analyte sensor signal from the obtained measurements indicative of analyte levels, the actual analyte sensor signal extending over a first period of time;', '(ii) identifying a start point and an end point of an artifact in the actual analyte sensor signal;', '(iii) replacing the artifact with a predicted analyte sensor signal;', '(iv) evaluating a difference between the predicted analyte sensor signal and the actual analyte sensor signal at the start point and the end point; and', '(v) using the differences as a feedback signal to correct the predicted analyte sensor signal and repeat (iii) using the corrected predicted analyte sensor signal., 'a sensor electronics unit in communications with the continuous analyte sensor and configured for use in retrospectively calibrating the continuous analyte sensor by2. The analyte sensor system of claim 1 , further comprising correcting the predicted analyte sensor signal by distributing the differences over a duration of the predicted analyte sensor signal to eliminate discontinuities in the corrected analyte sensor signal.3. The analyte sensor system of claim 2 , further comprising distributing the differences evenly over the predicted analyte sensor signal.4. The analyte sensor system of claim 2 , further comprising distributing the differences over the ...

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 112-. (canceled)13. A system for measuring an analyte concentration in a host , the system comprising: a first component comprising a sensor; and', 'a second component comprising sensor electronics configured to operatively connect to the sensor., 'a sensor system comprising Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 16/392,521, filed Apr. 23, 2019, which is a continuation of U.S. application Ser. No. 14/590,483, filed Jan. 6, 2015, now U.S. Pat. No. 10,314,525, which is a continuation of U.S. application Ser. No. 13/909,962, filed Jun. 4, 2013, now U.S. Pat. No. 9,247,900, which is a continuation of U.S. application Ser. No. 11/360,262, filed Feb. 22, 2006, now U.S. Pat. No. 8,615,282. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification.The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.Diabetes mellitus is a disorder in which the pancreas cannot create sufficient insulin (Type I or insulin dependent) and/or in which insulin is not effective (Type or non-insulin dependent). In the diabetic state, the victim suffers from high blood sugar, which can cause an array of physiological derangements associated with the deterioration of small blood vessels, for example, kidney failure, skin ulcers, or bleeding into the vitreous of the eye. A hypoglycemic reaction (low blood sugar) can be induced by an inadvertent ...

Devices, systems, and methods to compensate for effects of temperature on implantable sensors

Systems and methods for compensating for effects of temperature on implantable sensors are provided. In some embodiments, systems and methods are provided for measuring a temperature to determine a change in temperature in a sensor environment. In certain embodiments, a temperature compensation factor is determined based on a change in temperature of the sensor environment. The temperature compensation factor can be used in processing raw data of an analyte signal to report a more accurate analyte concentration.

SYSTEMS AND METHODS FOR SECURING A CONTINUOUS ANALYTE SENSOR TO A HOST

Adhesive pad systems that provide longer lasting adherence of the mounting unit to the host's skin are provided. Some systems include a reinforcing overlay that at least partially covers the adhesive pad. The reinforcing overlay may be removable without disturbing the sensor so that the overlay may be replaceable.

PARTICLE-CONTAINING MEMBRANE AND PARTICULATE ELECTRODE FOR ANALYTE SENSORS

Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 1. A system for continuous in vivo measurement of an analyte in a host , the system comprising:a continuous analyte sensor configured for implantation in a host and configured to generate a signal indicative of an analyte concentration; anda layer disposed over at least a portion of the sensor, wherein the layer comprises a particle-containing domain comprising a metal, wherein the particle-containing domain is configured to react with at least one interfering species.2. The system of claim 1 , wherein the particle-containing domain is more distal to the sensor than other domains of the layer.3. The system of claim 1 , wherein the particle-containing domain comprises at least one material selected from the group consisting of platinum claim 1 , platinum-iridium claim 1 , iridium claim 1 , palladium claim 1 , graphite claim 1 , gold claim 1 , silver claim 1 , silver chloride claim 1 , carbon claim 1 , and conductive polymers.4. The system of claim 1 , wherein the metal comprises sputtered metal.5. The system of claim 4 , wherein the sputtered metal is platinum.6. The system of claim 1 , wherein the particle-containing domain comprises a conductive particles concentration that is sufficient for the particle-containing domain to function as a conductive film.7. The system of claim 1 , wherein the particle-containing domain is configured to reduce flux therethrough of hydrogen peroxide.8. The system of claim 1 , wherein the particle-containing domain is non-powered.9. The system of claim 1 , wherein the particle-containing domain is powered.10. The system of claim 9 , wherein the sensor electronics are configured to apply a potential to the particle-containing domain.11. The system ...

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 1. An analyte monitoring system , the system comprising: a first wire comprising a working electrode configured to generate a signal indicative of an analyte concentration;', 'a second wire comprising a reference electrode; and', 'a third wire comprising a counter electrode; and, "an electrochemical sensor configured to measure a level of an analyte in a biological sample from a patient, wherein the biological sample is a tear, wherein the sensor is configured to be fastened to a portion of a patient's body, wherein the sensor is configured to be powered by inductive coupling, wherein the sensor comprises:"}sensor electronics configured to operatively connected to the sensor, wherein the sensor electronics are configured to process data obtained from the sensor.2. The system of claim 1 , wherein the first wire claim 1 , second wire claim 1 , and third wire are formed of metal.3. The system of claim 1 , wherein the first wire comprises platinum.4. The system of claim 1 , wherein the second wire comprises silver/silver chloride.5. The system of claim 1 , wherein the third wire comprises platinum.6. The system of claim 1 , wherein at least one of the first wire claim 1 , second wire claim 1 , or third wire is in a coiled configuration during sensor use.7. The system of claim 1 , wherein the sensor further comprises a membrane comprising an enzyme configured to react with the analyte claim 1 , wherein at least a portion of the working electrode is covered by the membrane.8. The system of claim 7 , wherein the enzyme is configured to react with glucose to produce hydrogen peroxide.9. The system of claim 8 , wherein the working electrode is configured to oxidize hydrogen peroxide to generate the signal indicative of the analyte concentration.10. The ...

MULTIPLE ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR, AND RELATED METHODS

In one embodiment, a continuous analyte sensor having more than one working electrode, and configured to reduce or eliminate crosstalk between the working electrodes. In another embodiment, a continuous analyte sensor having more than one working electrode, and configured so that a membrane system has equal thicknesses over each of the electrodes, despite having differing numbers of layers over each of the electrodes. In another embodiment, a configuration for connecting a continuous analyte sensor to sensor electronics. In another embodiment, methods for forming precise windows in an insulator material on a multi-electrode assembly. In another embodiment, a contact assembly for a continuous analyte sensor having more than one working electrode. 1. A continuous analyte sensor , comprising:a first working electrode;a second working electrode; anda membrane overlying at least a portion of the sensor, including the first and second working electrodes, the membrane being continuous, but for a first portion located between the first and second working electrodes that has properties that differ from properties of other portions of the membrane.2. The continuous analyte sensor of claim 1 , wherein at least one of the properties is permeability.3. The continuous analyte sensor of claim 2 , wherein the first portion is cross-linked.4. The continuous analyte sensor of claim 2 , wherein the other portions are cross-linked claim 2 , and the first portion is cross-linked by an amount different from the other portions.5. The continuous analyte sensor of claim 2 , wherein the first portion has a lower content of a hydrophilic species than the other portions.6. The continuous analyte sensor of claim 5 , wherein the hydrophilic species is removed by a secondary removal process claim 5 , a leaching process claim 5 , or a precipitation process involving heat claim 5 , pH claim 5 , or solvents.7. The continuous analyte sensor of claim 1 , wherein the first portion comprises a ...

Particle-containing membrane and particulate electrode for analyte sensors

Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 1. An electrochemical continuous glucose sensor configured for implantation in a host , the glucose sensor comprising:an electrode configured to measure a signal indicative of a glucose concentration of a host, wherein the signal comprises a glucose-related component and a non-glucose related component; anda membrane covering at least a portion of the electrode, wherein the membrane is configured to reduce passage of an interfering species therethrough, whereby the non-glucose-related component of the signal is less than about 20% of the signal over a period of at least one day;wherein the glucose sensor has a sensitivity to glucose of from about 25 pA/mg/dL to about 500 pA/mg/dL.2. The glucose sensor of claim 1 , wherein the interfering species has an oxidation potential that overlaps with an oxidation potential of a measured species indicative of the concentration of the analyte.3. The glucose sensor of claim 1 , wherein the measured species is a product of an enzymatic reaction between glucose and an enzyme and is measured by the electrode.4. The glucose sensor of claim 1 , wherein the membrane comprises a silicone-containing polymer.5. The glucose sensor of claim 4 , wherein the silicone-containing polymer is a polysiloxanes.6. The glucose sensor of claim 4 , wherein the silicone-containing polymer is a polycarbosiloxane.7. The glucose sensor of wherein the silicone-containing polymer is a copolymer comprising a silicone segment and a polyurethane segment.8. The glucose sensor of claim 1 , wherein the membrane comprises a fluorocarbon-based material.9. The glucose sensor of claim 1 , wherein the non-glucose-related component ...

Particle-containing membrane and particulate electrode for analyte sensors

Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

ANALYTE SENSOR WITH INCREASED REFERENCE CAPACITY

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes an electrochemical sensor incorporating a silver/silver chloride reference electrode, wherein a capacity of the reference electrode is controlled. 1. An implantable electrochemical sensor for measuring an analyte concentration in a host , comprising:a working electrode configured to measure a concentration of an analyte; anda silver/silver chloride reference electrode, wherein at least a portion of the silver/silver chloride reference electrode is covered with an enzyme layer, wherein the enzyme layer is configured, in vivo, to generate hydrogen peroxide upon exposure to a substrate, whereby the hydrogen peroxide regenerates silver chloride of the reference electrode such that a reference capacity of the reference electrode is increased.2. The implantable electrochemical sensor of claim 1 , wherein the enzyme is an oxidase enzyme.3. The implantable electrochemical sensor of claim 2 , wherein the substrate is selected from the group consisting of glucose claim 2 , urate claim 2 , ascorbate claim 2 , citrate claim 2 , L-lactate claim 2 , succinate claim 2 , D-glucose claim 2 , and ethanol.4. The implantable electrochemical sensor of claim 1 , wherein the analyte is glucose.5. The implantable electrochemical sensor of claim 1 , wherein the reference electrode comprises a chloridized elongated silver body.6. The implantable electrochemical sensor of claim 1 , further comprising a diffusion barrier configured to substantially block diffusion of hydrogen peroxide between the silver/silver chloride reference electrode and the working electrode.7. The implantable electrochemical sensor of claim 1 , wherein the enzyme layer has a thickness from about 0.01 microns to about 12 microns thick.8. The implantable electrochemical sensor of claim 1 , wherein a percentage of a surface area of the reference ...

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 112-. (canceled)13. A system for measuring an analyte concentration in a host , the system comprising:a transcutaneous analyte sensor; andsensor electronics configured to operatively connect to the transcutaneous analyte sensor.14. A method for processing data from a transcutaneous analyte sensor , the method comprising:receiving sensor data from the transcutaneous analyte sensor after the transcutaneous analyte sensor is implanted in a host, wherein the sensor data is indicative of an analyte concentration in the host; andprocessing, using a processor, the sensor data received from the transcutaneous analyte sensor. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 16/691,358, filed Nov. 21, 2019, which is a continuation of U.S. application Ser. No. 16/674,610, filed Nov. 5, 2019, which is a continuation of U.S. application Ser. No. 16/392,521, filed Apr. 23, 2019, which is a continuation of U.S. application Ser. No. 14/590,483, filed Jan. 6, 2015, now U.S. Pat. No. 10,314,525, which is a continuation of U.S. application Ser. No. 13/909,962, filed Jun. 4, 2013, now U.S. Pat. No. 9,247,900, which is a continuation of U.S. application Ser. No. 11/360,262, filed Feb. 22, 2006, now U.S. Pat. No. 8,615,282. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification. The aforementioned application is incorporated by reference herein in its entirety, and is hereby expressly made a part of this specification.The present invention relates generally to systems and methods for measuring an analyte ...

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 112-. (canceled)13. A system for measuring an analyte concentration in a host , the system comprising:a transcutaneous analyte sensor; andsensor electronics configured to operatively connect to the transcutaneous analyte sensor.14. A method for processing data from a transcutaneous analyte sensor , the method comprising:receiving sensor data from the transcutaneous analyte sensor after the transcutaneous analyte sensor is implanted in a host, wherein the sensor data is indicative of an analyte concentration in the host; andprocessing, using a processor, the sensor data received from the transcutaneous analyte sensor. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 16/691,358, filed Nov. 21, 2019, which is a continuation of U.S. application Ser. No. 16/674,610, filed Nov. 5, 2019, which is a continuation of U.S. application Ser. No. 16/392,521, filed Apr. 23, 2019, which is a continuation of U.S. application Ser. No. 14/590,483, filed Jan. 6, 2015, now U.S. Pat. No. 10,314,525, which is a continuation of U.S. application Ser. No. 13/909,962, filed Jun. 4, 2013, now U.S. Pat. No. 9,247,900, which is a continuation of U.S. application Ser. No. 11/360,262, filed Feb. 22, 2006, now U.S. Pat. No. 8,615,282. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification. The aforementioned application is incorporated by reference herein in its entirety, and is hereby expressly made a part of this specification.The present invention relates generally to systems and methods for measuring an analyte ...

DEVICES USED IN CONNECTION WITH CONTINUOUS ANALYTE MONITORING THAT PROVIDE THE USER WITH ONE OR MORE NOTIFICATIONS, AND RELATED METHODS

Devices and methods for providing a user with alerts are provided. The alerts may take different forms, such as an output to a display, a speaker, a vibration module, a shock module, etc. The alerts provide the user with sufficient information to take appropriate action, but the devices may be of limited functionality to enhance their compactness, discreetness, wearability, etc., while also lowering their cost to manufacture. 1. A wearable device for providing an alert to a user regarding the user's blood glucose value , the device comprising:a communication module for receiving a signal from a transmitter of a continuous glucose monitoring device; andan alert interface configured to provide a first alert when the wearer's blood glucose value is within a predetermined range, and a second alert that the wearer's blood glucose value is outside the predetermined range.2. The device of claim 1 , further comprising a band configured to be worn about a wrist of a wearer claim 1 , wherein the communication module and the alert interface are incorporated into the band.3. The device of claim 2 , wherein the band comprises a closed loop having no endpoints.4. The device of claim 3 , wherein the band is constructed of a resilient material.5. The device of claim 1 , wherein the alert interface comprises a display including at least one of a liquid crystal display claim 1 , one or more light-emitting diodes claim 1 , one or more organic light-emitting diodes claim 1 , an electronic paper display claim 1 , a color- or pattern-changing material claim 1 , or a text display.6. The device of claim 1 , wherein the communication module is configured to relay the signal received from the transmitter to another electronic device.7. The device of claim 6 , wherein the communication module is configured to store data received from the transmitter and relay the data to the other electronic device at regular intervals.8. The device of claim 7 , wherein the device is configured to process or ...

ANALYTE SENSOR

Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system is provided having a first working electrode comprising a first sensor element and a second working electrode comprising a second sensor element , and a reference electrode for providing a reference value for measuring the working electrode potential of the sensor elements 1. A sensor system for continuous measurement of a glucose concentration in a host , the sensor system comprising:a first sensor configured to measure glucose concentrations over a first time period of in vivo implantation; anda second sensor configured to measure glucose concentrations over a second time period of in vivo implantation, wherein the first time period and the second time period are different.2. The sensor system of claim 1 , wherein the first time period corresponds to an initial period of in vivo implantation claim 1 , wherein the second time period corresponds to a second time period of in vivo implantation claim 1 , and wherein the second period begins after the initial period of in vivo implantation has begun.3. The sensor system of claim 2 , wherein the first time period and the second time period overlap partially claim ...

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Analyte sensor

Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system 180 is provided having a first working electrode 150 comprising a first sensor element 102 and a second working electrode 160 comprising ...

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 112-. (canceled)13. A system for measuring an analyte concentration in a host , the system comprising:a transcutaneous analyte sensor; andsensor electronics configured to operatively connect to the transcutaneous analyte sensor.14. A method for processing data from a transcutaneous analyte sensor , the method comprising:receiving sensor data indicative of an analyte concentration in the host; andprocessing, using a processor, the sensor data. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 16/924,117, filed Jul. 8, 2020, which is a continuation of U.S. application Ser. No. 16/691,358, filed Nov. 21, 2019, now U.S. Pat. No. 10,709,362, which is a continuation of U.S. application Ser. No. 16/674,610, filed Nov. 5, 2019, now U.S. Pat. No. 10,722,152, which is a continuation of U.S. application Ser. No. 16/392,521, filed Apr. 23, 2019, which is a continuation of U.S. application Ser. No. 14/590,483, filed Jan. 6, 2015, now U.S. Pat. No. 10,314,525, which is a continuation of U.S. application Ser. No. 13/909,962, filed Jun. 4, 2013, now U.S. Pat. No. 9,247,900, which is a continuation of U.S. application Ser. No. 11/360,262, filed Feb. 22, 2006, now U.S. Pat. No. 8,615,282. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification. The aforementioned application is incorporated by reference herein in its entirety, and is hereby expressly made a part of this specification.The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, ...

ANALYTE SENSORS AND METHODS OF MANUFACTURING SAME

Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.

PARTICLE-CONTAINING MEMBRANE AND PARTICULATE ELECTRODE FOR ANALYTE SENSORS

Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 120-. (canceled)21. A system for measuring an analyte concentration in a host , the system comprising:a working electrode configured to be implanted in a host, wherein the electrode comprises rhodium;a membrane disposed over the electrode, wherein the membrane comprises an enzyme; andsensor electronics configured to generate a signal indicative of a concentration of the species in the host.22. The system of claim 21 , wherein the sensor electronics are configured to apply a potential of from about 0.1V to about 0.8V is applied to the working electrode.23. The system of claim 22 , wherein the sensor electronics are configured to apply a potential of from about 0.3V to about 0.7V to the working electrode.24. The system of claim 23 , wherein the sensor electronics are configured to apply a potential of from about 0.3V to about 0.5V to the working electrode.25. The system of claim 24 , wherein the potential applied is constant.26. The system of claim 22 , wherein potential applied is cyclical claim 22 , pulsed claim 22 , intermittent claim 22 , variable claim 22 , or a combination thereof.27. The system of claim 21 , wherein the membrane comprises polyurethane.28. The system of claim 21 , where the analyte is glucose.29. The system of claim 21 , wherein the analyte is lactate.30. The system of claim 21 , wherein the enzyme is glucose oxidase.31. The system of claim 21 , wherein the working electrode comprises conductive particles that form a network and function as an array of microelectrodes.32. The system of claim 21 , wherein the rhodium is disposed on a substrate.33. The system of claim 32 , wherein the substrate is formed of a metal.34. The system of claim 33 , wherein the ...

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Analyte sensor with increased reference capacity

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes an electrochemical sensor incorporating a silver/silver chloride reference electrode, wherein a capacity of the reference electrode is controlled.

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 112-. (canceled)13. A system for measuring an analyte concentration in a host , the system comprising:a transcutaneous analyte sensor; andsensor electronics configured to operatively connect to the transcutaneous analyte sensor.14. A method for processing data from a transcutaneous analyte sensor , the method comprising:receiving sensor data indicative of an analyte concentration in the host; andprocessing, using a processor, the sensor data. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 16/924,117, filed Jul. 8, 2020, which is a continuation of U.S. application Ser. No. 16/691,358, filed Nov. 21, 2019, now U.S. Pat. No. 10,709,362, which is a continuation of U.S. application Ser. No. 16/674,610, filed Nov. 5, 2019, now U.S. Pat. No. 10,722,152, which is a continuation of U.S. application Ser. No. 16/392,521, filed Apr. 23, 2019, which is a continuation of U.S. application Ser. No. 14/590,483, filed Jan. 6, 2015, now U.S. Pat. No. 10,314,525, which is a continuation of U.S. application Ser. No. 13/909,962, filed Jun. 4, 2013, now U.S. Pat. No. 9,247,900, which is a continuation of U.S. application Ser. No. 11/360,262, filed Feb. 22, 2006, now U.S. Pat. No. 8,615,282. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification. The aforementioned application is incorporated by reference herein in its entirety, and is hereby expressly made a part of this specification.The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, ...

Analyte sensor

Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system 180 is provided having a first working electrode 150 comprising a first sensor element 102 and a second working electrode 160 comprising ...

Automatic analyte sensor calibration and error detection

Systems and methods are provided that address the need to frequently calibrate analyte sensors, according to implementation. In more detail, systems and methods provide a preconnected analyte sensor system that physically combines an analyte sensor to measurement electronics during the manufacturing phase of the sensor and in some cases in subsequent life phases of the sensor, so as to allow an improved recognition of sensor environment over time to improve subsequent calibration of the sensor.

AUTOMATIC ANALYTE SENSOR CALIBRATION AND ERROR DETECTION

Systems and methods are provided that address the need to frequently calibrate analyte sensors, according to implementation. In more detail, systems and methods provide a preconnected analyte sensor system that physically combines an analyte sensor to measurement electronics during the manufacturing phase of the sensor and in some cases in subsequent life phases of the sensor, so as to allow an improved recognition of sensor environment over time to improve subsequent calibration of the sensor. 1. A preconnected sensor assembly comprising:a sensor wire;a housing; andsensor electronics, where the sensor is preconnected to a housing and/or to sensor electronics, and wherein the sensor wire is at least preconnected to an interposer which is configured for allowing measurements of sensor physical properties without requiring a direct connection to the sensor wire.2. The sensor assembly of claim 1 , wherein a battery is preconnected to the sensor wire and the housing and/or sensor electronics.3. The sensor assembly of claim 2 , wherein a radio is preconnected to the battery and the sensor wire and the housing and/or sensor electronics.4. A method of calibrating a sensor claim 1 , the sensor associated with the preconnected sensor assembly of claim 1 , wherein the sensor experiences a plurality of life phases including manufacture claim 1 , shipping claim 1 , storage and insertion and use in a user as part of a sensor session claim 1 , comprising:disposing measurement electronics in operable connection to the sensor;during the manufacture life phase in a factory, the manufacture life phase manufacturing a sensor using a plurality of manufacturing parameters, determining a first calibration factor;during the shipping or storage phases, determining a second calibration factor; andupon insertion in a user, using a combination calibration factor in a user monitoring device to calibrate signals from the sensor, wherein the combination calibration factor is based on both the ...

DEVICES, SYSTEMS, AND METHODS TO COMPENSATE FOR EFFECTS OF TEMPERATURE ON IMPLANTABLE SENSORS

Systems and methods for compensating for effects of temperature on implantable sensors are provided. In some embodiments, systems and methods are provided for measuring a temperature to determine a change in temperature in a sensor environment. In certain embodiments, a temperature compensation factor is determined based on a change in temperature of the sensor environment. The temperature compensation factor can be used in processing raw data of an analyte signal to report a more accurate analyte concentration. 1. A device for continuous in vivo measurement of glucose concentrations in a host , comprising:at least one electrode operatively connected to electronic circuitry configured to generate a signal representative of a concentration of glucose in a host;at least one membrane located over at least a portion of the electrode, the at least one membrane comprising an enzyme configured to catalyze a reaction of glucose and oxygen from a biological fluid in contact with the membrane in vivo; anda temperature sensor configured to measure at least one of an in vivo temperature or a change in temperature in vivo.2. The device of claim 1 , wherein the at least one electrode comprises a first electrode and a second electrode.3. The device of claim 2 , wherein the at least one membrane comprises a first membrane located over at least a portion of the first electrode and a second membrane located over at least a portion of the second electrode claim 2 , and wherein the first membrane and the second membrane each have a different temperature coefficient.4. The device of claim 3 , wherein the first membrane and the second membrane each have a different composition.5. The device of claim 3 , wherein the first membrane and the second membrane are each configured to exhibit a different change in dimension in response to a change in temperature in vivo.6. The device of claim 3 , wherein the first membrane and the second membrane are each configured to exhibit a different change ...

Analyte sensor with increased reference capacity

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes an electrochemical sensor incorporating a silver/silver chloride reference electrode, wherein a capacity of the reference electrode is controlled.

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transeutaneous measurement of glucose in a host. 1. An analyte monitoring system , the system comprising: a first wire comprising a working electrode configured to generate a signal indicative of an analyte concentration;', 'a second wire comprising a reference electrode; and', 'a third wire comprising a counter electrode; and, "an electrochemical sensor configured to measure a level of an analyte in a biological sample from a patient, wherein the biological sample is a tear, wherein the sensor is configured to be fastened to a portion of a patient's body, wherein the sensor is configured to be powered by inductive coupling, wherein the sensor comprises:"}sensor electronics configured to operatively connect to the sensor, wherein the sensor electronics are configured to process data obtained from the sensor.2. The system of claim 1 , wherein the first wire claim 1 , second wire claim 1 , and third wire are formed of metal.3. The system of claim 1 , wherein the first wire comprises platinum.4. The system of claim 1 , wherein the second wire comprises silver/silver chloride.5. The system of claim 1 , wherein the third wire comprises platinum.6. The system of claim 1 , wherein at least one of the first wire claim 1 , second wire claim 1 , or third wire is in a coiled configuration during sensor use.7. The system of claim 1 , wherein the sensor further comprises a membrane comprising an enzyme configured to react with the analyte claim 1 , wherein at least a portion of the working electrode is covered by the membrane.8. The system of claim 7 , wherein the enzyme is configured to react with glucose to produce hydrogen peroxide.9. The system of claim 8 , wherein the working electrode is configured to oxidize hydrogen peroxide to generate the signal indicative of the analyte concentration.10. The ...

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 1. An analyte monitoring system , the system comprising: a first wire comprising a working electrode configured to generate a signal indicative of an analyte concentration;', 'a second wire comprising a reference electrode; and', 'a third wire comprising a counter electrode; and, "an electrochemical sensor configured to measure a level of an analyte in a biological sample from a patient, wherein the biological sample is a tear, wherein the sensor is configured to be fastened to a portion of a patient's body, wherein the sensor is configured to be powered by inductive coupling, wherein the sensor comprises:"}sensor electronics configured to operatively connect to the sensor, wherein the sensor electronics are configured to process data obtained from the sensor.2. The system of claim 1 , wherein the first wire claim 1 , second wire claim 1 , and third wire are formed of metal.3. The system of claim 1 , wherein the first wire comprises platinum.4. The system of claim 1 , wherein the second wire comprises silver/silver chloride.5. The system of claim 1 , wherein the third wire comprises platinum.6. The system of claim 1 , wherein at least one of the first wire claim 1 , second wire claim 1 , or third wire is in a coiled configuration during sensor use.7. The system of claim 1 , wherein the sensor further comprises a membrane comprising an enzyme configured to react with the analyte claim 1 , wherein at least a portion of the working electrode is covered by the membrane.8. The system of claim 7 , wherein the enzyme is configured to react with glucose to produce hydrogen peroxide.9. The system of claim 8 , wherein the working electrode is configured to oxidize hydrogen peroxide to generate the signal indicative of the analyte concentration.10. The ...

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 112-. (canceled)13. A system for measuring an analyte concentration in a host , the system comprising:a transcutaneous analyte sensor; andsensor electronics configured to operatively connect to the transcutaneous analyte sensor.14. A method for processing data from a transcutaneous analyte sensor , the method comprising:receiving sensor data from the transcutaneous analyte sensor after the transcutaneous analyte sensor is implanted in a host, wherein the sensor data is indicative of an analyte concentration in the host; andprocessing, using a processor, the sensor data received from the transcutaneous analyte sensor. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 16/691,358, filed Nov. 21, 2019, which is a continuation of U.S. application Ser. No. 16/674,610, filed Nov. 5, 2019, which is a continuation of U.S. application Ser. No. 16/392,521, filed Apr. 23, 2019, which is a continuation of U.S. application Ser. No. 14/590,483, filed Jan. 6, 2015, now U.S. Pat. No. 10,314,525, which is a continuation of U.S. application Ser. No. 13/909,962, filed Jun. 4, 2013, now U.S. Pat. No. 9,247,900, which is a continuation of U.S. application Ser. No. 11/360,262, filed Feb. 22, 2006, now U.S. Pat. No. 8,615,282. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification. The aforementioned application is incorporated by reference herein in its entirety, and is hereby expressly made a part of this specification.The present invention relates generally to systems and methods for measuring an analyte ...

Devices used in connection with continuous analyte monitoring that provide the user with one or more notifications, and related methods

Devices and methods for providing a user with alerts are provided. The alerts may take different forms, such as an output to a display, a speaker, a vibration module, a shock module, etc. The alerts provide the user with sufficient information to take appropriate action, but the devices may be of limited functionality to enhance their compactness, discreetness, wearability, etc., while also lowering their cost to manufacture.

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 1. An electrochemical continuous glucose sensor configured for implantation in a host , the glucose sensor comprising:an electrode configured to measure a signal indicative of a glucose concentration of a host, wherein the signal comprises a glucose-related component and a non-glucose related component; anda membrane covering at least a portion of the electrode, wherein the membrane is configured to reduce passage of an interfering species therethrough, whereby the non-glucose-related component of the signal is less than about 20% of the signal over a period of at least one day;wherein the glucose sensor has a sensitivity to glucose of from about 25 pA/mg/dL to about 500 pA/mg/dL.2. The glucose sensor of claim 1 , wherein the interfering species has an oxidation potential that overlaps with an oxidation potential of a measured species indicative of the concentration of the analyte.3. The glucose sensor of claim 1 , wherein the measured species is a product of an enzymatic reaction between glucose and an enzyme and is measured by the electrode.4. The glucose sensor of claim 1 , wherein the membrane comprises a silicone-containing polymer.5. The glucose sensor of claim 4 , wherein the silicone-containing polymer is a polysiloxanes.6. The glucose sensor of claim 4 , wherein the silicone-containing polymer is a polycarbosiloxane.7. The glucose sensor of wherein the silicone-containing polymer is a copolymer comprising a silicone segment and a polyurethane segment.8. The glucose sensor of claim 1 , wherein the membrane comprises a fluorocarbon-based material.9. The glucose sensor of claim 1 , wherein the non-glucose-related component ...

ANALYTE SENSOR WITH INCREASED REFERENCE CAPACITY

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes an electrochemical sensor incorporating a silver/silver chloride reference electrode, wherein a capacity of the reference electrode is controlled. 1. An electrochemical sensor for measuring an analyte concentration in a host , comprising:a working electrode configured to measure a concentration of an analyte; anda reference electrode comprising a material that depletes during sensor use, wherein the material is configured to be regenerated during sensor use, and wherein a rate of material depletion during sensor use substantially correlates with a rate of material regeneration during sensor use over a time period.2. The electrochemical sensor of claim 1 , wherein a correlation between the rate of material regeneration and the rate of material depletion is positive.3. The electrochemical sensor of claim 1 , wherein the sensor is configured to increase the rate of material regeneration responsive to an increase in the rate of material depletion.4. The electrochemical sensor of claim 1 , wherein the sensor is configured to decrease the rate of material regeneration responsive to a decrease in the rate of material depletion.5. The electrochemical sensor of claim 1 , wherein at least a portion of the reference electrode is covered with an enzyme layer.6. The electrochemical sensor of claim 5 , wherein the enzyme is an oxidase enzyme.7. The electrochemical sensor of claim 1 , wherein the analyte is glucose.8. The electrochemical sensor of claim 1 , wherein the material is silver chloride.9. The electrochemical sensor of claim 1 , wherein the reference electrode is formed of a chloridized elongated silver body.10. The electrochemical sensor of claim 1 , wherein the enzyme layer has a thickness from about 0.01 microns to about 12 microns thick.11. The electrochemical sensor of claim 1 , wherein a ...

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 112-. (canceled)13. A system for measuring an analyte concentration in a host , the system comprising:a transcutaneous analyte sensor; andsensor electronics configured to operatively connect to the transcutaneous analyte sensor.14. A method for processing data from a transcutaneous analyte sensor , the method comprising:receiving sensor data indicative of an analyte concentration in the host; andprocessing, using a processor, the sensor data. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 16/924,117, filed Jul. 8, 2020, which is a continuation of U.S. application Ser. No. 16/691,358, filed Nov. 21, 2019, now U.S. Pat. No. 10,709,362, which is a continuation of U.S. application Ser. No. 16/674,610, filed Nov. 5, 2019, now U.S. Pat. No. 10,722,152, which is a continuation of U.S. application Ser. No. 16/392,521, filed Apr. 23, 2019, which is a continuation of U.S. application Ser. No. 14/590,483, filed Jan. 6, 2015, now U.S. Pat. No. 10,314,525, which is a continuation of U.S. application Ser. No. 13/909,962, filed Jun. 4, 2013, now U.S. Pat. No. 9,247,900, which is a continuation of U.S. application Ser. No. 11/360,262, filed Feb. 22, 2006, now U.S. Pat. No. 8,615,282. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification. The aforementioned application is incorporated by reference herein in its entirety, and is hereby expressly made a part of this specification.The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, ...

Devices, systems, and methods to compensate for effects of temperature on implantable sensors

Systems and methods for compensating for effects of temperature on implantable sensors are provided. In some embodiments, systems and methods are provided for measuring a temperature to determine a change in temperature in a sensor environment. In certain embodiments, a temperature compensation factor is determined based on a change in temperature of the sensor environment. The temperature compensation factor can be used in processing raw data of an analyte signal to report a more accurate analyte concentration.

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Automatic analyte sensor calibration and error detection

Systems and methods are provided that address the need to frequently calibrate analyte sensors, according to implementation. In more detail, systems and methods provide a preconnected analyte sensor system that physically combines an analyte sensor to measurement electronics during the manufacturing phase of the sensor and in some cases in subsequent life phases of the sensor, so as to allow an improved recognition of sensor environment over time to improve subsequent calibration of the sensor.

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

DEVICES, SYSTEMS, AND METHODS TO COMPENSATE FOR EFFECTS OF TEMPERATURE ON IMPLANTABLE SENSORS

Systems and methods for compensating for effects of temperature on implantable sensors are provided. In some embodiments, systems and methods are provided for measuring a temperature to determine a change in temperature in a sensor environment. In certain embodiments, a temperature compensation factor is determined based on a change in temperature of the sensor environment. The temperature compensation factor can be used in processing raw data of an analyte signal to report a more accurate analyte concentration.

ANALYTE SENSOR

Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system is provided having a first working electrode comprising a first sensor element and a second working electrode comprising a second sensor element , and a reference electrode for providing a reference value for measuring the working electrode potential of the sensor elements 1. A sensor system for continuous measurement of a glucose concentration in a host , the sensor system comprising:a first sensor configured to measure glucose concentrations over a first time period of in vivo implantation; anda second sensor configured to measure glucose concentrations over a second time period of in vivo implantation, wherein the first time period and the second time period are different.2. The sensor system of claim 1 , wherein the first time period corresponds to an initial period of in vivo implantation claim 1 , wherein the second time period corresponds to a second time period of in vivo implantation claim 1 , and wherein the second period begins after the initial period of in vivo implantation has begun.3. The sensor system of claim 2 , wherein the first time period and the second time period overlap partially claim ...

Particle-containing membrane and particulate electrode for analyte sensors

Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

AUTOMATIC ANALYTE SENSOR CALIBRATION AND ERROR DETECTION

Systems and methods are provided that address the need to frequently calibrate analyte sensors, according to implementation. In more detail, systems and methods provide a preconnected analyte sensor system that physically combines an analyte sensor to measurement electronics during the manufacturing phase of the sensor and in some cases in subsequent life phases of the sensor, so as to allow an improved recognition of sensor environment over time to improve subsequent calibration of the sensor. 1. A method for self-calibration of an analyte sensor system that includes an analyte sensor operatively coupled to sensor electronics , comprising:applying a bias voltage with the sensor electronics to the analyte sensor to generate sensor data, the analyte sensor system having an initial characteristic metric determined at a first time when the analyte sensor is operatively connected to one or more components of the sensor electronics;using the sensor electronics at a second time subsequent to the first time to determine a change to the initial characteristic metric of the analyte sensor system based at least in part on one or more manufacturing and/or environmental parameters, wherein the second time is before or during sensor use in vivo; andusing the sensor electronics to automatically calibrate, without user intervention, the analyte sensor system based at least in part on the determined change to the initial characteristic metric.2. A method for self-calibrating an analyte sensor system that includes an analyte sensor operatively coupled to sensor electronics , comprising:applying a bias voltage with the sensor electronics to the analyte sensor to generate sensor data, the analyte sensor system having an initial calibration factor that is used to convert sensor data to analyte concentration values;using the sensor electronics to update the calibration factor of the analyte sensor system at a plurality of times during one or more life phases of the analyte sensor based ...

Devices, systems, and methods to compensate for effects of temperature on implantable sensors

Systems and methods for compensating for effects of temperature on implantable sensors are provided. In some embodiments, systems and methods are provided for measuring a temperature to determine a change in temperature in a sensor environment. In certain embodiments, a temperature compensation factor is determined based on a change in temperature of the sensor environment. The temperature compensation factor can be used in processing raw data of an analyte signal to report a more accurate analyte concentration.

Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

SYSTEMS AND METHODS FOR SECURING A CONTINUOUS ANALYTE SENSOR TO A HOST

Adhesive pad systems that provide longer lasting adherence of the mounting unit to the host's skin are provided. Some systems include a reinforcing overlay that at least partially covers the adhesive pad. The reinforcing overlay may be removable without disturbing the sensor so that the overlay may be replaceable. 1. An adhesive pad system for securing a continuous analyte sensor assembly to skin of a host , the system comprising:a housing configured to receive a sensor electronics unit;an adhesive layer configured to adhere to a host's skin, the adhesive layer having an upper surface and an undersurface, wherein the undersurface of the adhesive layer includes an adhesive material configured to adhere the adhesive layer to the skin of the host; anda cushioning layer configured to adhere to the adhesive layer, the cushioning layer having an upper surface and an undersurface, wherein the undersurface of the cushioning layer includes an adhesive material configured to adhere the cushioning layer to the upper surface of the adhesive layer, the cushioning layer further having a first thickness.2. The system of claim 1 , wherein the adhesive layer has a second thickness that is less than the first thickness claim 1 , wherein the adhesive layer has a larger perimeter dimension than the cushioning layer claim 1 , such that the adhesive layer extends outwardly on all sides from a periphery of the cushioning layer when the cushioning layer is positioned over the adhesive layer.3. The system of claim 1 , further comprising a layer of double-sided tape configured to be interposed between the adhesive layer and the sensor electronics unit housing.4. The system of claim 3 , wherein the double-sided tape has a smaller perimeter dimension than both the overlay and the cushioning layer.5. The system of claim 1 , wherein the upper surface of the cushioning layer abuts and adheres to a bottom surface of the electronics unit housing.6. The system of claim 1 , wherein the housing ...

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 1. An analyte monitoring system , the system comprising: a first wire comprising a working electrode configured to generate a signal indicative of an analyte concentration;', 'a second wire comprising a reference electrode; and', 'a third wire comprising a counter electrode; and, "an electrochemical sensor configured to measure a level of an analyte in a biological sample from a patient, wherein the biological sample is a tear, wherein the sensor is configured to be fastened to a portion of a patient's body, wherein the sensor is configured to be powered by inductive coupling, wherein the sensor comprises:"}sensor electronics configured to operatively connected to the sensor, whereinthe sensor electronics are configured to process data obtained from the sensor.2. The system of claim 1 , wherein the first wire claim 1 , second wire claim 1 , and third wire are formed of metal.3. The system of claim 1 , wherein the first wire comprises platinum.4. The system of claim 1 , wherein the second wire comprises silver/silver chloride.5. The system of claim 1 , wherein the third wire comprises platinum.6. The system of claim 1 , wherein at least one of the first wire claim 1 , second wire claim 1 , or third wire is in a coiled configuration during sensor use.7. The system of claim 1 , wherein the sensor further comprises a membrane comprising an enzyme configured to react with the analyte claim 1 , wherein at least a portion of the working electrode is covered by the membrane.8. The system of claim 7 , wherein the enzyme is configured to react with glucose to produce hydrogen peroxide.9. The system of claim 8 , wherein the working electrode is configured to oxidize hydrogen peroxide to generate the signal indicative of the analyte concentration.10. The ...

PARTICLE-CONTAINING MEMBRANE AND PARTICULATE ELECTRODE FOR ANALYTE SENSORS

Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 120-. (canceled)21. A system for continuous in vivo measurement of glucose in a host , the system comprising:a continuous glucose sensor configured for implantation in a host and configured to measure in vivo a signal indicative of a glucose concentration, wherein the continuous glucose sensor comprises an electrode, wherein the electrode comprises a metal oxide and a plurality of sensing elements, wherein each sensing element comprises an electroactive surface, and wherein each sensing element is configured to detect the signal related to glucose concentration;a biocompatible membrane located over at least a portion of the electrode, wherein the biocompatible membrane is configured to reduce a flux of glucose therethrough; andsensor electronics operably connected to the continuous glucose sensor, wherein the sensor electronics are configured to process the signal from the continuous glucose sensor.22. The system of claim 21 , wherein the system is configured to determine glucose concentration by averaging or integrating signals from plurality of sensing elements.23. The system of claim 21 , wherein each of the electroactive surfaces is shaped like a circle.24. The system of claim 21 , wherein each of the electroactive surfaces is shaped like a dot.25. The system of claim 21 , wherein the electroactive surfaces all have a substantially equal area.26. The system of claim 21 , wherein the electroactive surfaces are each spaced apart from at least one adjacent electroactive surface by a substantially equal distance.27. The system of claim 21 , wherein the electroactive surfaces are spaced along a substantial length of an in vivo portion of the glucose sensor.28. The system of ...

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

SYSTEMS AND METHODS FOR PATIENT MONITORING USING AN HCP-SPECIFIC DEVICE

Systems and methods disclosed provide ways for Health Care Professionals (HCPs) to be involved in initial patient system set up so that the data received is truly transformative, such that the patient not just understands what all the various numbers mean but also how the data can be used. For example, in one implementation, a CGM device is configured for use by a HCP, and includes a housing and a circuit configured to receive a signal from a transmitter coupled to an indwelling glucose sensor. A calibration module converts the received signal into clinical units. A user interface is provided that is configured to display a measured glucose concentration in the clinical units. The user interface is further configured to receive input data about a patient level, where the input data about the patient level causes the device to operate in a mode appropriate to the patient level. 1. A method of configuring a continuous glucose monitoring device for use by a patient , the configuring performed by an HCP , comprising:establishing a communication session associated with an HCP account between an HCP client device and a server;on a user interface associated with the HCP client device, prompting an HCP to enter patient data;also on the user interface associated with the client device, prompting an HCP to enter identifying data corresponding to a transmitter and/or sensor, the transmitter and/or sensor associated with the continuous glucose monitoring device;receiving the entered patient data and the sensor identifying data, and transmitting the entered patient data and the identifying data to the server for storage and association with a patient account.2. The method of claim 1 , wherein the identifying data is identifying data about a transmitter.3. The method of claim 1 , further comprising receiving an output from the server in response to the transmitting entered patient data and the identifying data to the server claim 1 , wherein the received output includes a code ...

ANALYTE SENSOR WITH INCREASED REFERENCE CAPACITY

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes an electrochemical sensor incorporating a silver/silver chloride reference electrode, wherein a capacity of the reference electrode is controlled.

ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 112-. (canceled)13. A system for measuring an analyte concentration in a host , the system comprising:a transcutaneous analyte sensor; andsensor electronics configured to operatively connect to the transcutaneous analyte sensor.14. A method for processing data from a transcutaneous glucose sensor , the method comprising:receiving sensor data from the transcutaneous analyte sensor after the transcutaneous analyte sensor is implanted in a host, wherein the sensor data is indicative of an analyte concentration in the host; andprocessing, using a processor, the sensor data received from the transcutaneous analyte sensor. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 16/674,610, filed Nov. 5, 2019, which is a continuation of U.S. application Ser. No. 16/392,521, filed Apr. 23, 2019, which is a continuation of U.S. application Ser. No. 14/590,483, filed Jan. 6, 2015, now U.S. Pat. No. 10,314,525, which is a continuation of U.S. application Ser. No. 13/909,962, filed Jun. 4, 2013, now U.S. Pat. No. 9,247,900, which is a continuation of U.S. application Ser. No. 11/360,262, filed Feb. 22, 2006, now U.S. Pat. No. 8,615,282. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification. The aforementioned application is incorporated by reference herein in its entirety, and is hereby expressly made a part of this specification.The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods ...

DEVICES, SYSTEMS, AND METHODS TO COMPENSATE FOR EFFECTS OF TEMPERATURE ON IMPLANTABLE SENSORS

Systems and methods for compensating for effects of temperature on implantable sensors are provided. In some embodiments, systems and methods are provided for measuring a temperature to determine a change in temperature in a sensor environment. In certain embodiments, a temperature compensation factor is determined based on a change in temperature of the sensor environment. The temperature compensation factor can be used in processing raw data of an analyte signal to report a more accurate analyte concentration. 1. A device for continuous in vivo measurement of glucose concentrations in a host , comprising:at least one electrode operatively connected to electronic circuitry configured to generate a signal representative of a concentration of glucose in a host;at least one membrane located over at least a portion of the electrode, the at least one membrane comprising an enzyme configured to catalyze a reaction of glucose and oxygen from a biological fluid in contact with the membrane in vivo; anda temperature sensor configured to measure at least one of an in vivo temperature or a change in temperature in vivo.2. The device of claim 1 , wherein the at least one electrode comprises a first electrode and a second electrode.3. The device of claim 2 , wherein the at least one membrane comprises a first membrane located over at least a portion of the first electrode and a second membrane located over at least a portion of the second electrode claim 2 , and wherein the first membrane and the second membrane each have a different temperature coefficient.4. The device of claim 3 , wherein the first membrane and the second membrane each have a different composition.5. The device of claim 3 , wherein the first membrane and the second membrane are each configured to exhibit a different change in dimension in response to a change in temperature in vivo.6. The device of claim 3 , wherein the first membrane and the second membrane are each configured to exhibit a different change ...

Analyte sensor with increased reference capacity

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes an electrochemical sensor incorporating a silver/silver chloride reference electrode, wherein a capacity of the reference electrode is controlled.

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

ANALYTE SENSOR

Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system is provided having a first working electrode comprising a first sensor element and a second working electrode comprising a second sensor element , and a reference electrode for providing a reference value for measuring the working electrode potential of the sensor elements 1. A sensor system for continuous measurement of a glucose concentration in a host , the sensor system comprising:a first sensor configured to measure glucose concentrations over a first time period of in vivo implantation; anda second sensor configured to measure glucose concentrations over a second time period of in vivo implantation, wherein the first time period and the second time period are different.2. The sensor system of claim 1 , wherein the first time period corresponds to an initial period of in vivo implantation claim 1 , wherein the second time period corresponds to a second time period of in vivo implantation claim 1 , and wherein the second period begins after the initial period of in vivo implantation has begun.3. The sensor system of claim 2 , wherein the first time period and the second time period overlap partially claim ...

Analyte sensor

Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system 180 is provided having a first working electrode 150 comprising a first sensor element 102 and a second working electrode 160 comprising a second sensor element 104 , and a reference electrode 108 for providing a reference value for measuring the working electrode potential of the sensor elements 102, 104.

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 120-. (canceled)21. An electrochemical continuous glucose sensor configured for implantation in a host , the glucose sensor comprising:an electrode comprising a plurality of electroactive surfaces each configured to measure a signal indicative of a glucose concentration of a host; anda membrane covering at least a portion of the electrode, wherein the membrane comprises an enzyme configured to react with glucose.22. The glucose sensor of claim 21 , wherein each of the electroactive surfaces is shaped like a circle.23. The glucose sensor of claim 21 , wherein each of the electroactive surfaces is shaped like a dot.24. The glucose sensor of claim 21 , wherein the plurality of electroactive surfaces all have a substantially equal area.25. The glucose sensor of claim 21 , wherein the plurality of electroactive surfaces are each spaced apart from at least one adjacent electroactive surface by a substantially equal distance.26. The glucose sensor of claim 21 , wherein the plurality of electroactive surfaces are spaced along a substantial length of an in vivo portion of the glucose sensor.27. The glucose sensor of claim 21 , wherein the membrane comprises a layer configured to control a diffusion of glucose therethrough claim 21 , wherein the layer comprises polyurethane.28. The glucose sensor of claim 21 , wherein the glucose sensor has a planar shape.29. The glucose sensor of claim 21 , wherein the plurality of electroactive surfaces comprise at more than two electroactive surfaces.30. The glucose sensor of claim 21 , wherein the plurality of electroactive surfaces comprise at more than three electroactive surfaces.31. The glucose ...

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 120-. (canceled)21. An electrochemical continuous glucose sensor configured for implantation in a host , the glucose sensor comprising:an electrode configured to measure a signal indicative of a glucose concentration of a host; anda membrane covering at least a portion of the electrode, wherein the membrane comprises a first domain configured to reduce passage of an interfering species therethrough and a second domain comprising an enzyme configured to react with glucose, wherein the first domain is configured to trap interfering species having a molecular weight equal to or greater than a molecular weight of acetaminophen and configured to prevent the interfering species from reaching the electrode, wherein the first domain is positioned between the second domain and the electrode.22. The glucose sensor of claim 21 , wherein the molecular weight is about 151 Daltons.23. The glucose sensor of claim 21 , wherein the interfering species has an oxidation potential that substantially overlaps with an oxidation potential of a measured species indicative of the concentration of the analyte.24. The glucose sensor of claim 23 , wherein the measured species is a product of an enzymatic reaction between glucose and an enzyme and is measured by the electrode.25. The glucose sensor of claim 21 , wherein the glucose sensor has a sensitivity to glucose of from about 25 pA/mg/dL to about 500 pA/mg/dL.26. The glucose sensor of claim 21 , wherein the membrane further comprises a third domain configured to reduce a flux of glucose therethough.27. The glucose sensor of claim 26 , wherein the third domain comprises a product of a reaction of an ...

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host using a transcutaneous analyte sensor system including an applicator (12), a mounting unit (14), an electronics unit (16), a base (24), a sensor (32), and one or more contacts (28) configured to provide secure electrical contact between the sensor and the electronics unit (16).

Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host using a transcutaneous analyte sensor system including an applicator (12), a mounting unit (14), an electronics unit (16), a base (24), a sensor (32), and one or more contacts (28) configured to provide secure electrical contact between the sensor and the electronics unit (16).

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host using a transcutaneous analyte sensor system including an applicator (12), a mounting unit (14), an electronics unit (16), a base (24), a sensor (32), and one or more contacts (28) configured to provide secure electrical contact between the sensor and the electronics unit (16).

Analyte sensor

Herein is disclosed a glucose measuring system, the system comprising an on-skin device configured to measure, process and store glucose sensor data, the on-skin device including a mounting unit adapted for mounting on a skin of a host, an electronics unit connected to the mounting unit, the electronics unit configured to perform the processing and storing, and a sensor for measuring a level of glucose in a host, the sensor comprising an in vivo portion for insertion through the skin at an exit site of the host and an ex vivo portion connected to the mounting unit, wherein the sensor is operably connected to the electronics unit; and a receiver for receiving and processing the glucose sensor data, and displaying the processed glucose sensor data on a user interface of the receiver, wherein the on-skin device is configured to transmit stored glucose sensor data when requested by the receiver, wherein the receiver requests the on-skin device to transmit the requested stored glucose sensor data when the receiver is held in close proximity to the device, and wherein the requesting and transmission use inductive coupling data transmission.

Analyte sensor

Herein is disclosed a glucose measuring system, the system comprising an on-skin device configured to measure, process and store glucose sensor data, the on-skin device including a mounting unit adapted for mounting on a skin of a host, an electronics unit connected to the mounting unit, the electronics unit configured to perform the processing and storing, and a sensor for measuring a level of glucose in a host, the sensor comprising anin vivoportion for insertion through the skin at an exit site of the host and anex vivoportion connected to the mounting unit, wherein the sensor is operably connected to the electronics unit; and a receiver for receiving and processing the glucose sensor data, and displaying the processed glucose sensor data on a user interface of the receiver, wherein the on-skin device is configured to transmit stored glucose sensor data when requested by the receiver, wherein the receiver requests the on-skin device to transmit the requested stored glucose sensor data when the receiver is held in close proximity to the device, and wherein the requesting and transmission use inductive coupling data transmission.

Analyte sensor

Herein is disclosed a glucose measuring system, the system comprising an on-skin device configured to measure, process and store glucose sensor data, the on-skin device including a mounting unit adapted for mounting on a skin of a host, an electronics unit connected to the mounting unit, the electronics unit configured to perform the processing and storing, and a sensor for measuring a level of glucose in a host, the sensor comprising an in vivo portion for insertion through the skin at an exit site of the host and an ex vivo portion connected to the mounting unit, wherein the sensor is operably connected to the electronics unit; and a receiver for receiving and processing the glucose sensor data, and displaying the processed glucose sensor data on a user interface of the receiver, wherein the on-skin device is configured to transmit stored glucose sensor data when requested by the receiver, wherein the receiver requests the on-skin device to transmit the requested stored glucose sensor data when the receiver is held in close proximity to the device, and wherein the requesting and transmission use inductive coupling data transmission.

Analyte sensor

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host using a transcutaneous analyte sensor system including an applicator (12), a mounting unit (14), an electronics unit (16), a base (24), a sensor (32), and one or more contacts (28) configured to provide secure electrical contact between the sensor and the electronics unit (16).

Systems and methods for patient monitoring using an hcp - specific device

Systems and methods disclosed provide ways for Health Care Professionals (HCPs) to he involved in initial patient system set up so that the data received is truly transformative, such that the patient not just understands what all the various numbers mean but also how the data can be used. For example, in one implementation, a CGM device is configured for use by a HCP, and includes a housing and a circuit configured to receive a signal from a transmitter coupled to an indwelling glucose sensor. A calibration module converts the received signal into clinical units. A user interface is provided that is configured to display a measured glucose concentration in the clinical units. The user interface is further configured to receive input data about a patient level, where the input data about the patient level causes the device to operate in a mode appropriate to the patient level.

Analyte sensor

Sistema de medición de glucosa, comprendiendo el sistema: un dispositivo sobre la piel configurado para medir, procesar y almacenar datos de sensor de glucosa, incluyendo el dispositivo sobre la piel una unidad (14) de montaje adaptada para montarse sobre la piel de un huésped y una unidad (16) de electrónica conectada a la unidad (14) de montaje, estando la unidad (16) de electrónica configurada para realizar el procesamiento y el almacenamiento; y un sensor para medir un nivel de glucosa en el huésped, comprendiendo el sensor una porción in vivo para su inserción a través de la piel en un sitio de salida del huésped y una porción ex vivo conectada a la unidad (14) de montaje, en el que el sensor está operativamente conectado a la unidad (16) de electrónica; y comprendiendo el sistema además un receptor (158), que es un dispositivo informático portátil remoto con respecto al dispositivo sobre la piel para recibir y procesar los datos de sensor de glucosa, y visualizar los datos de sensor de glucosa procesados en una interfaz de usuario del receptor (158), caracterizado porque el dispositivo sobre la piel está configurado para transmitir datos de sensor de glucosa almacenados cuando lo pide el receptor (158), en el que el receptor (158) pide al dispositivo sobre la piel que transmita los datos de glucosa almacenados pedidos cuando el receptor (158) se mantiene en estrecha proximidad con el dispositivo sobre la piel, en el que la petición y la transmisión usan transmisión de datos por acoplamiento inductivo. Glucose measurement system, the system comprising: a skin device configured to measure, process and store glucose sensor data, the skin device including a mounting unit (14) adapted to be mounted on the skin of a host and an electronics unit (16) connected to the mounting unit (14), the electronics unit (16) being configured to perform processing and storage; and a sensor for measuring a glucose level in the host, the sensor comprising an in vivo portion for ...

Analyte sensor