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09-02-2012 дата публикации

SILICONE BASED MEMBRANES FOR USE IN IMPLANTABLE GLUCOSE SENSORS

Номер: US20120035445A1
Автор: Boock Robert, Rixman Monica
Принадлежит: DexCom, Inc.

Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility. 1. An implantable continuous analyte sensor , comprising:a working electrode; anda membrane disposed over at least a portion of the working electrode, the membrane comprising a blend, the blend comprising a silicone polymer and a hydrophilic polymer.2. The implantable continuous analyte sensor of claim 1 , wherein the silicone polymer is cross-linked with the hydrophilic polymer.3. The implantable continuous analyte sensor of claim 1 , wherein the hydrophilic polymer has a molecular weight of at least about 1 claim 1 ,000 g/mol.4. The implantable continuous analyte sensor of claim 1 , wherein the hydrophilic polymer has a molecular weight of at least about 10 claim 1 ,000 g/mol.5. The implantable continuous analyte sensor of claim 1 , wherein the hydrophilic polymer has a molecular weight of at least about 15 claim 1 ,000 g/mol.6. The implantable continuous analyte sensor of claim 1 , wherein up to 25% of the silicone polymer is covalently linked to the hydrophilic polymer.7. The implantable continuous analyte sensor of claim 1 , wherein up to 15% of the silicone polymer is covalently linked to the hydrophilic polymer.8. The implantable continuous analyte sensor of claim 1 , wherein up to 5% of the silicone polymer is covalently linked to the hydrophilic polymer.9. The implantable continuous analyte sensor of claim 1 , wherein the hydrophilic polymer comprises a material selected from the group consisting of polyvinylpyrrolidone claim 1 , polyhydroxyethyl methacrylate claim 1 , polyvinylalcohol claim 1 , polyacrylic acid claim 1 , polyethers claim 1 , and copolymers thereof ...

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Номер записи: 1
16-02-2012 дата публикации

TECHNIQUES TO IMPROVE POLYURETHANE MEMBRANES FOR IMPLANTABLE GLUCOSE SENSORS

Номер: US20120040101A1
Автор:
Принадлежит: DexCom, Inc.

The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor. 1. A method for fabricating a device for measuring a concentration of an analyte , the method comprising:providing a sensor mechanism configured to measure an analyte or a product of a reaction associated with the analyte;forming a solution comprising a blend of a first polymer and a second polymer, wherein a segment of the first polymer and a segment of the second polymer are both formed of a same monomer unit;maintaining the solution at a temperature sufficient to maintain solubility of the first polymer and the second polymer;applying the solution to the sensor mechanism;forming a film from the solution at the temperature; anddrying the film to form a membrane.2. The method of claim 1 , wherein the monomer unit is selected from the group consisting of a polyurethane claim 1 , a vinyl polymer claim 1 , a polyether claim 1 , a polyester claim 1 , a polyamide claim 1 , a polysiloxane claim 1 , and a polycarbosiloxane.3. The method of claim 1 , wherein the second polymer is a hydrophobic-hydrophilic co-polymer comprising a hydrophobic segment and a hydrophilic segment.4. The method of claim 1 , wherein the second polymer comprises a polyurethane segment.5. The method of claim 1 , wherein the membrane has a thickness of from about 5 microns to about 100 microns.6. The method of claim 1 , wherein the analyte is glucose.7. The method of claim 6 , wherein the membrane has an ...

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Номер записи: 2
23-02-2012 дата публикации

ANALYTE SENSING BIOINTERFACE

Номер: US20120046534A1
Автор:
Принадлежит: DexCom, Inc.

Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface. 1. A glucose sensor configured for implantation in a host , comprising:a biocompatible matrix comprising a scaffolding having a porosity;a working electrode comprising an electrically conductive material, wherein an electroactive surface of the working electrode is distributed throughout the biocompatible matrix; andelectronics electrically coupled to the working electrode, wherein, in use, the electronics are configured to detect a current flowing through the working electrode or a voltage of the working electrode, wherein the current or voltage is indicative of a quantity of an analyte within the porosity.2. The glucose sensor of claim 1 , wherein the scaffolding comprises an electrically non-conductive material.3. The glucose sensor of claim 2 , wherein the scaffolding further comprises an electrically conductive material.4. The glucose sensor of claim 1 , wherein the scaffolding is substantially planar.5. The glucose sensor of claim 1 , wherein the biocompatible matrix comprises an enzyme.6. The glucose sensor of claim 5 , wherein the biocompatible matrix further comprises a resistance domain disposed over the enzyme.7. The glucose sensor of claim 5 , wherein the biocompatible matrix further comprises a bioactive agent.8. A sensor for measuring glucose in a host claim 5 , the sensor comprising:a biointerface, the biointerface comprising a porous biointerface material, wherein electroactive surfaces are distributed within at least some pores in the biointerface, and wherein the electroactive surfaces have a membrane coating disposed thereon; andelectronics electrically ...

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Номер записи: 3
29-03-2012 дата публикации

ADVANCED CONTINUOUS ANALYTE MONITORING SYSTEM

Номер: US20120078071A1
Автор: Bohm Sebastian, Dervaes Mark, JOHNSON Eric, Kamath Apurv Ullas, Larvenz Shawn, Leach Jacob S., Lieu Phong, Mahalingam Aarthi, Miller Tom, Neale Paul V., Peyser Thomas A., Pryor Jack, Rong Daiting, San Vicente Kenneth, Shariati Mohammad Ali, Simpson Peter C., Wightlin Matthew
Принадлежит: DexCom, Inc.

Systems and methods for processing, transmitting, and displaying data received from a continuous analyte (e.g., glucose) sensor are provided. A sensor system can comprise a sensor electronics module that includes power saving features, e.g., a low power measurement circuit that can be switched between a measurement mode and a low power mode, wherein charging circuitry continues to apply power to electrodes of a sensor during the low power mode. The sensor electronics module can be switched between a low power storage mode and a higher power operational mode via a switch, e.g., a reed switch or optical switch. A validation routine can be implemented to ensure an interrupt signal sent from the switch is valid. The sensor can be physically connected to the sensor electronics module in direct wireless communication with a plurality of different display devices. 1. A system for continuous measurement of an analyte in a host , the system comprising:a continuous analyte sensor; anda sensor electronics module coupled to the sensor, the sensor electronics module comprising measurement circuitry, power circuitry, and charging circuitry,wherein the sensor electronics module is configured to switch between a first mode and a second mode,wherein in the first mode the power circuitry is coupled to the measurement circuitry and the charging circuitry, the measurement circuitry is coupled to the continuous analyte sensor, and the charging circuitry is decoupled from the continuous analyte sensor, andwherein in the second mode the power circuitry is decoupled from the measurement circuitry and the charging circuitry, the measurement circuitry is decoupled from the continuous analyte sensor, and the charging circuitry is coupled to the continuous analyte sensor.2. The system of claim 2 , wherein the sensor comprises a plurality of electrodes.3. The system of claim 3 , wherein the measurement circuitry applies a voltage across the electrodes of the sensor during the first mode and the ...

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Номер записи: 4
03-05-2012 дата публикации

CONTINUOUS ANALYTE MONITOR DATA RECORDING DEVICE OPERABLE IN A BLINDED MODE

Номер: US20120108934A1
Автор: Bowman Leif N., Cote Kristin, Price David, Valdes Jorge
Принадлежит: DexCom, Inc.

A system is provided including a continuous analyte sensor that produces a data stream indicative of a host's analyte concentration and a device that receives and records data from the data stream from the continuous analyte sensor. The data received from the continuous analyte sensor may be used to provide alarms to the user when the analyte concentration and/or the rate of change of analyte concentration, as measured by the continuous analyte sensor, is above or below a predetermined range. Data received from the continuous analyte sensor may also be used to prompt the diabetic or caregiver to take certain actions, such as to perform another single point blood glucose measurement. The device may provide for toggling between modes that allow or prevent the display of glucose concentration values associated with the continuous glucose sensor. 1. A system for monitoring glucose concentration , the system comprising:a continuous glucose sensor, the continuous glucose sensor configured to continuously measure glucose concentration and output a data stream associated with glucose concentration; anda device configured to operatively connect with the continuous glucose sensor, the device comprising a single point glucose monitor, at least one processor configured to process the data stream from the continuous glucose sensor, and a user interface configured to display measured glucose concentration values associated with the single point glucose monitor.2. The system of claim 1 , wherein the device is configured to not display glucose concentration values associated with the data stream from the continuous glucose sensor.3. The system of claim 1 , wherein the device is configured for toggling between a first mode allowing for display of glucose concentration values associated with the continuous glucose sensor and a second mode preventing display of glucose concentration values associated with the continuous glucose sensor.4. The system of claim 1 , wherein the at least ...

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Номер записи: 5
24-05-2012 дата публикации

Analyte sensor

Номер: US20120130214A1
Автор: James Brauker, Mark Brister, Sean Saint, Vance Swanson
Принадлежит: Dexcom Inc

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

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Номер записи: 6
05-07-2012 дата публикации

TRANSCUTANEOUS ANALYTE SENSOR

Номер: US20120172691A1
Автор:
Принадлежит: DexCom, Inc.

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 1. A method for calibrating a continuous glucose monitoring system , comprising:positioning at least a portion of an electrochemical glucose sensor in a body of a user;obtaining a signal from the electrochemical glucose sensor;determining, using a processor, a rate of change of the obtained signal; anddetermining, using the processor, whether calibration is appropriate based on the determined rate of change.2. The method of claim 1 , wherein determining whether calibration is appropriate comprises comparing the determined rate of change to a predetermined value.3. The method of claim 2 , wherein the predetermined value is approximately 1 mg/dL per minute or less.4. The method of claim 2 , wherein claim 2 , when the determined rate of change is above the predetermined value claim 2 , determining that calibration is not appropriate.5. The method of claim 4 , further comprising waiting a predetermined time period before performing calibration.6. The method of claim 2 , wherein the predetermined value is approximately 1.5 mg/dL per minute.7. The method of claim 6 , wherein claim 6 , when the determined rate of change is below the predetermined value claim 6 , determining that calibration is appropriate.8. The method of claim 1 , further comprising performing calibration using a blood sample to calibrate the electrochemical glucose sensor signal.9. The method of claim 1 , further comprising determining an acceleration of the obtained signal claim 1 , wherein determining whether calibration is appropriate is based on the determined acceleration of the obtained signal.10. A method for calibrating a continuous glucose monitoring system claim 1 , comprising:positioning at least a portion of a glucose sensor in a body of a user;obtaining a plurality of ...

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Номер записи: 7
12-07-2012 дата публикации

DEVICE AND METHOD FOR DETERMINING ANALYTE LEVELS

Номер: US20120179014A1
Автор: Gilligan Barbara J., Rhodes Rathbun K., Shults Mark C., Tapsak Mark A., Updike Stuart J.
Принадлежит: DexCom, Inc.

Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time. 1. An implantable sensor for measuring an analyte , the sensor comprising:an electrode configured to measure an analyte; anda membrane disposed on at least a portion of the electrode, the membrane comprising a first domain that comprises polyurethane and polyvinylpyrrolidone and a second domain that comprises an enzyme, wherein the first domain is configured to prevent entry of inflammatory cells, and wherein the first domain is distal to the second domain with respect to the electrode.2. The sensor of claim 1 , wherein the polyurethane is polycarbonateurethane.3. The sensor of claim 1 , wherein the first domain further comprises at least one material selected from the group consisting of polytetrafluoroethylene claim 1 , polypropylene claim 1 , polysulfone claim 1 , and polyethylene terephthalate.4. The sensor of claim 1 , wherein the first domain further comprises at least one material selected from the group consisting of polytetrafluoroethylene claim 1 , polypropylene claim 1 , polysulfone claim 1 , and polyethylene terephthalate.5. The sensor of claim 1 , wherein the analyte is glucose.6. The sensor of claim 5 , wherein the enzyme is glucose oxidase. This application is a continuation of Ser. No. 12/696,003, filed Jan. 28, 2010, which is a continuation of Ser. No. 11/546,157, filed Oct. 10, 2006, which is a continuation of Ser. No. 11/039,269, filed Jan. 19, 2005, now U.S. Pat. No. 7,136,689, which is a continuation of Ser. No. 09/916,858, filed Jul. 27, 2001, now U.S. Pat. No. 6,862,465, which is a continuation-in-part of Ser. No. 09/447,227, ...

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Номер записи: 8
26-07-2012 дата публикации

INTEGRATED DELIVERY DEVICE FOR CONTINUOUS GLUCOSE SENSOR

Номер: US20120186581A1
Автор: Brauker James H., Kamath Apurv U., Markovic Dubravka, Mensinger Michael Robert, Neale Paul V., Saint Sean T., Simpson Peter C., Tapsak Mark A.
Принадлежит: DexCom,Inc.

Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction. 1. An integrated system for monitoring and treating diabetes , the system comprising:a glucose sensor, wherein the glucose sensor substantially continuously measures glucose in a host for a period exceeding one hour, and outputs a data stream, including one or more sensor data points;a receiver operably connected to the glucose sensor, wherein the receiver is configured to receive the data stream; anda medicament delivery device, wherein the delivery device is physically detachably connectable to the receiver, wherein at least one of the receiver and the medicament delivery device comprises programming that automatically detects impending clinical risk and calculates a therapy recommendation responsive to the impending clinical risk, and wherein the at least one of the receiver and the medicament delivery device further comprises programming that requires the at least one of the receiver and the medicament delivery device to be at least one of validated and confirmed by a user interaction in response to a prompt ...

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Номер записи: 9
26-07-2012 дата публикации

INTEGRATED DELIVERY DEVICE FOR CONTINUOUS GLUCOSE SENSOR

Номер: US20120190953A1
Автор:
Принадлежит: DexCom, Inc.

Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction. 1. An integrated system for monitoring and treating diabetes , the system comprising:a glucose sensor, wherein the glucose sensor substantially continuously measures glucose in a host for a period exceeding one hour, and outputs a data stream, including one or more sensor data points;a receiver operably connected to the glucose sensor, wherein the receiver is configured to receive the data stream; anda medicament delivery device, wherein the delivery device is at least one of physically and operably connectable to the receiver, wherein the receiver is configured to receive medicament delivery data responsive to medicament delivery for a first time period from the medicament delivery device, and wherein the receiver comprises a processor, and wherein the processor comprises programming configured to determine a host's metabolic response to the medicament delivery by evaluating the sensor data points substantially corresponding to delivery and release of the medicament delivery for the first time period, wherein the ...

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Номер записи: 10
26-07-2012 дата публикации

INTEGRATED DELIVERY DEVICE FOR CONTINUOUS GLUCOSE SENSOR

Номер: US20120191063A1
Автор:
Принадлежит: DexCom, Inc.

Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction. 1. An integrated system for monitoring and treating diabetes , the system comprising:a continuous glucose sensor, wherein the glucose sensor substantially continuously measures glucose in a host for a period exceeding one hour, and outputs a data stream, including one or more sensor data points;a receiver operably connected to the glucose sensor, wherein the receiver is configured to receive the data stream; a medicament delivery device, wherein the delivery device is at least one of physically connectable and operably connectable to the receiver; anda single point glucose monitor configured to receive a biological sample from the host and measure a concentration of glucose in the sample, wherein the single point glucose monitor is operably connectable to the receiver, and wherein the receiver comprises a processor module configured to calculate at least one parameter of a medicament to deliver via the medicament delivery device, wherein the parameter is selected from the group consisting of a type of medicament, ...

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Номер записи: 11
09-08-2012 дата публикации

SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM

Номер: US20120203467A1
Автор:
Принадлежит: DexCom, Inc.

Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as interfering species, ischemia, pH changes, temperatures changes, known or unknown sources of mechanical, electrical and/or biochemical noise, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system processes some or the entire data stream continually or intermittently based at least in part on whether the signal artifact event has occurred. 1. A method for estimating an analyte value from a continuous analyte sensor , the method comprisingreceiving a data stream from the continuous analyte sensor for a time period;evaluating the data stream;estimating at least one analyte value for a future time period based on the data stream; andwherein the estimating is based on the evaluation.2. The method of claim 1 , wherein the evaluating comprises evaluating a rate of change.3. The method of claim 1 , wherein the evaluating comprises performing a first derivative analysis or a second derivative analysis.4. The method of claim 1 , wherein the evaluating comprises determining a level of confidence.5. The method of claim 1 , wherein the estimating is not performed responsive to the evaluation failing a criterion.6. The method of claim 1 , wherein the evaluating comprises determining a residual associated with the data stream.7. The method of claim 1 , wherein the estimating comprises post-processing the data stream.8. A system for estimating an analyte value from a continuous analyte sensor claim 1 , the system comprisinga sensor data receiving module configured to receive a data stream from the continuous analyte sensor for a time period;a processor module configured to evaluate the data stream and estimate at least one analyte value for a future time period based on the data stream based on the ...

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Номер записи: 12
16-08-2012 дата публикации

SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA

Номер: US20120209098A1
Автор:
Принадлежит: DexCom, Inc.

Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor. 1. A method for evaluating clinical acceptability of at least one of reference and sensor analyte data , the method comprising:receiving sensor data from a continuous analyte sensor, including one or more sensor data points;receiving reference data from a reference analyte monitor, including one or more reference data points; and ["(i) said reference data using substantially time corresponding sensor data, wherein said reference data is evaluated for deviation from its substantially time corresponding sensor data in units of blood glucose concentration and clinical risk associated with that deviation based on a user's blood glucose concentration as indicated by at least one of said reference data and said sensor data; and", "(ii) said sensor data using substantially time corresponding reference data, wherein said sensor data is evaluated for deviation from its substantially time corresponding reference data in units of blood glucose concentration and clinical risk associated with that deviation based on a user's blood glucose concentration as indicated by at least one of said sensor data ...

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Номер записи: 13
23-08-2012 дата публикации

SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM

Номер: US20120215086A1
Автор: Brauker James H., Kamath Apurv, LI Ying, Mahalingam Aarthi
Принадлежит: DexCom, Inc.

Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as interfering species, ischemia, pH changes, temperatures changes, known or unknown sources of mechanical, electrical and/or biochemical noise, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system processes some or the entire data stream continually or intermittently based at least in part on whether the signal artifact event has occurred. 1. A method for processing data from a glucose sensor , the method comprising:receiving sensor data corresponding to a time period from the glucose sensor, the sensor data representative of glucose values of a host for the time period;processing and displaying a graphical representation of the sensor data on a hand-held unit; andpost-processing and re-displaying a graphical representation of the sensor data corresponding to the time period on the handheld unit, whereby the post-processed and re-displayed graphical representation more closely represents the actual glucose values of the host for the time period.2. The method of claim 1 , wherein post-processing is conducted responsive to a request.3. The method of claim 1 , wherein post-processing is conducted automatically.4. The method of claim 1 , further comprising determining whether a signal artifact event has occurred claim 1 , wherein the post-processing is based at least in part upon whether the signal artifact event has occurred.5. The method of claim 4 , wherein a signal artifact event is determined to have occurred if a residual associated with the sensor data exceeds a threshold value.6. The method of claim 1 , wherein the displaying comprises displaying calibrated sensor data claim 1 , and wherein the post-processing comprises re-calibrating the sensor data corresponding to the time period claim ...

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Номер записи: 14
23-08-2012 дата публикации

INTEGRATED DELIVERY DEVICE FOR CONTINUOUS GLUCOSE SENSOR

Номер: US20120215201A1
Автор:
Принадлежит: DexCom, Inc.

Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction. 1. An integrated diabetes management system for selectively switching between fully-automated and semi-automated modes , the system comprising:a glucose sensor, wherein the glucose sensor is configured to substantially continuously measure glucose concentration in a host for a period exceeding one hour, and to output a data stream, including one or more sensor data points; anda processor module operably connected to the glucose sensor, wherein the processor module is configured to receive the data stream, to calculate a therapy comprising instructions for administration of a medicament, and to send the instructions to a medicament delivery device, wherein the processor module is configured to operate the integrated system in a fully-automated mode unless a semi-automated mode is triggered, wherein the fully automated mode does not require user interaction to send instructions to the medicament delivery device, wherein in the semi-automated mode, the processor module is configured to prompt the user for input ...

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Номер записи: 15
23-08-2012 дата публикации

SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA

Номер: US20120215461A1
Автор: Brauker James H., Goode, JR. Paul V., Kamath Apurv U., Thrower James P.
Принадлежит: DexCom, Inc.

Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor. 1. A method for processing at least one of reference glucose data or sensor glucose data , the method comprising:receiving sensor data from a continuous glucose sensor, the sensor data comprising one or more sensor data points;receiving reference data from a reference glucose monitor, the reference data comprising one or more reference data points;forming, using a processor module, a matched data pair by matching at least one sensor data point to at least one substantially time corresponding reference data point;determining, using the processor module, a zone out of a plurality of predetermined zones into which the matched data pair falls based on a deviation of the sensor data and the reference data of the matched data pair and a user's blood glucose concentration value as indicated by at least one of the reference data and the sensor data, wherein the plurality of zones comprises at least one zone of a first type and at least one zone of a second type; andprocessing, using the processor module, at least one of the one or more sensor data points and the one or more reference data points ...

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Номер записи: 16
23-08-2012 дата публикации

SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA

Номер: US20120215462A1
Автор: Brauker James H., Goode, JR. Paul V., Kamath Apur U., Thrower James P.
Принадлежит: DexCom, Inc.

Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor. 1. A method for processing reference glucose values , the method comprising:receiving sensor data from a continuous glucose sensor;receiving reference data from a reference glucose monitor, the reference data corresponding in time to the sensor data;determining, using a processor module, an acceptability of the reference data, the determination comprising evaluating a deviation between the reference data and the sensor data by comparing the sensor data to a range of acceptable values, wherein the range of acceptable values varies depending upon a glucose concentration of a host as indicated by the reference data; andprocessing, using the processor module, the reference data responsive to the acceptability determination.2. The method of claim 1 , wherein the processing comprises calibrating the sensor data based at least in part on the reference data when it is determined that the reference data is acceptable.3. The method of claim 1 , wherein the processing comprises requesting new reference data when it is determined that the reference data is unacceptable by prompting a user to provide ...

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Номер записи: 17
23-08-2012 дата публикации

SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM

Номер: US20120215496A1
Автор:
Принадлежит: DexCom, Inc.

Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as interfering species, ischemia, pH changes, temperatures changes, known or unknown sources of mechanical, electrical and/or biochemical noise, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system processes some or the entire data stream continually or intermittently based at least in part on whether the signal artifact event has occurred. 1. A method for processing sensor data from a continuous glucose sensor , the method comprising:receiving continuous glucose sensor data, the continuous glucose sensor data comprising a plurality of sensor data points;classifying a level of noise associated with the continuous glucose sensor data during a first time period, whereby a noise classification is determined; andselectively displaying one or more of a representation of raw continuous glucose sensor data, a representation of filtered continuous glucose sensor data, a representation of a range of data values associated with the continuous glucose sensor data, a representation of a direction of the continuous glucose sensor data, a representation of a level of confidence of the continuous glucose sensor data, a low resolution representation of the continuous glucose sensor data or a representation of predicted continuous glucose sensor data for a future time period, wherein the one or more representations are selectively displayed based on the noise classification.2. The method of claim 1 , wherein classifying a level of noise comprises performing at least one of a first derivative analysis or a second derivative analysis of the continuous glucose sensor data for a time period.3. The method of claim 1 , wherein classifying a level of noise comprises comparing raw data and filtered data to obtain at ...

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Номер записи: 18
30-08-2012 дата публикации

INTEGRATED DELIVERY DEVICE FOR CONTINUOUS GLUCOSE SENSOR

Номер: US20120220979A1
Автор:
Принадлежит: DexCom, Inc.

Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction. 1. An integrated diabetes management system for selectively switching between fully-automated and semi-automated modes , the system comprising:a glucose sensor, wherein the glucose sensor is configured to substantially continuously measure glucose concentration in a host for a period exceeding one hour, and to output a data stream, including one or more sensor data points; anda processor module operably connected to the glucose sensor, wherein the processor module is configured to receive the data stream, calculate a therapy comprising instructions for administration of a medicament, and send the instructions to a medicament delivery device, wherein the processor module is configured to operate the integrated system in a fully-automated mode unless a semi-automated mode is triggered, wherein the fully automated mode does not require user interaction to send instructions to the medicament delivery device, wherein the semi-automated mode requires user interaction before sending instructions to the medicament ...

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Номер записи: 19
06-09-2012 дата публикации

CALIBRATION TECHNIQUES FOR A CONTINUOUS ANALYTE SENSOR

Номер: US20120226121A1
Автор:
Принадлежит: DexCom, Inc.

Disclosed herein are systems and methods for calibrating a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes one or more electrodes to measure an additional analyte. Such measurements may provide a baseline or sensitivity measurement for use in calibrating the sensor. Furthermore, baseline and/or sensitivity measurements may be used to trigger events such as digital filtering of data or suspending display of data. 1. A method for continuous glucose sensing , the method comprising:generating a glucose signal associated with a glucose concentration in a host using a continuous glucose sensor;measuring a sensitivity change of the continuous glucose sensor over a time period, wherein the measured sensitivity change is not based on a reference glucose measurement from a reference glucose monitor; anddetermining, using electronic circuitry, a stability of the continuous glucose sensor based on the measured sensitivity change; andcalibrating the glucose signal using the measured sensitivity change.2. The method of claim 1 , wherein measuring a sensitivity change comprises measuring a change in glucose transport through a membrane.3. The method of claim 1 , wherein measuring a sensitivity change comprises measuring an analyte other than glucose.4. The method of claim 1 , wherein measuring a sensitivity change comprises measuring a change in oxygen transport through a membrane.5. The method of claim 1 , wherein measuring a sensitivity change comprises switching claim 1 , cycling claim 1 , or pulsing a voltage and evaluating the voltage response.6. The method of claim 1 , wherein measuring a sensitivity change comprises measuring a change in baseline over time.7. The method of claim 1 , wherein measuring a sensitivity change comprises measuring an auxiliary signal.8. The method of claim 7 , wherein the auxiliary signal is indicative of a change in solute transport through a membrane.9. The method of claim 7 , wherein the auxiliary signal ...

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Номер записи: 20
13-09-2012 дата публикации

ELECTRODE SYSTEMS FOR ELECTROCHEMICAL SENSORS

Номер: US20120228134A1
Автор: Brauker James H., Carr-Brendel Victoria E., Petisce James R., Simpson Peter C.
Принадлежит: DexCom, Inc.

The present invention relates generally to systems and methods for improved electrochemical measurement of analytes. The preferred embodiments employ electrode systems including an analyte-measuring electrode for measuring the analyte or the product of an enzyme reaction with the analyte and an auxiliary electrode configured to generate oxygen and/or reduce electrochemical interferants. Oxygen generation by the auxiliary electrode advantageously improves oxygen availability to the enzyme and/or counter electrode; thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. Interferant modification by the auxiliary electrode advantageously renders them substantially non-reactive at the analyte-measuring electrode, thereby reducing or eliminating inaccuracies in the analyte signal due to electrochemical interferants. 1. An electrochemical sensor for determining a presence or a concentration of an analyte in a fluid , the sensor comprising:a membrane system comprising an enzyme, wherein the enzyme reacts with the analyte;an electroactive surface comprising a working electrode, the working electrode comprising a conductive material and configured to measure a product of the reaction of the enzyme with the analyte; andan auxiliary electrode comprising a conductive material and configured to generate oxygen, wherein the auxiliary electrode is situated such that the oxygen generated diffuses to the enzyme or to the electroactive surface.2. The electrochemical sensor of claim 1 , wherein the auxiliary electrode comprises a conductive material selected from the group consisting of a conductive metal claim 1 , a conductive polymer claim 1 , and a blend of a conductive metal and a conductive polymer.3. The electrochemical sensor of claim 1 , wherein the auxiliary electrode comprises a form selected from the group consisting of a mesh claim 1 , a grid claim 1 , and a plurality of spaced wires.4. The electrochemical ...

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Номер записи: 21
20-09-2012 дата публикации

INTEGRATED DELIVERY DEVICE FOR CONTINUOUS GLUCOSE SENSOR

Номер: US20120238852A1
Автор: Brauker James H., Kamath Apurv U., Markovic Dubravka, Mensinger Michael Robert, Neale Paul V., Saint Sean T., Simpson Peter C., Tapsak Mark A.
Принадлежит: DexCom, Inc.

Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction. 1. An integrated diabetes management system for selectively switching between fully-automated and semi-automated modes , the system comprising:a glucose sensor, wherein the glucose sensor is configured to substantially continuously measure glucose concentration in a host for a period exceeding one hour, and is configured to output a data stream, including one or more sensor data points; anda processor module operably connected to the glucose sensor, wherein the processor module is configured to receive the data stream, calculate a therapy comprising instructions for administration of a medicament, and send the instructions to a medicament delivery device, wherein the processor module is configured to operate the integrated system in a fully-automated mode unless a semi-automated mode is triggered, wherein the fully automated mode does not require user interaction to send instructions to the medicament delivery device, wherein the semi-automated mode requires user interaction before sending instructions to the ...

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Номер записи: 22
27-09-2012 дата публикации

SYSTEMS AND METHODS FOR PROCESSING SENSOR DATA

Номер: US20120245448A1
Автор: Dobbles J. Michael, Kamath Apurv Ullas, Mahalingam Aarthi, Shariati Mohammad Ali
Принадлежит: DexCom, Inc.

Systems and methods for processing sensor data are provided. In some embodiments, systems and methods are provided for calibration of a continuous analyte sensor. In some embodiments, systems and methods are provided for classification of a level of noise on a sensor signal. In some embodiments, systems and methods are provided for determining a rate of change for analyte concentration based on a continuous sensor signal. In some embodiments, systems and methods for alerting or alarming a patient based on prediction of glucose concentration are provided. 1. A method for classifying a level of noise in a signal obtained from a continuous glucose sensor based on a signal strength , the method comprising:receiving a signal from a continuous glucose sensor during a sensor session;classifying a level of noise in the signal into one of a plurality of different predetermined noise classifications during the sensor session based a plurality of noise thresholds; andcontrolling an output of information during the sensor session responsive to the noise classification, wherein the information is selected from the group consisting of rate of change information, alarm information, and medicament delivery information.2. The method of claim 1 , further comprising adaptively determining the one or more noise thresholds for classification of the level of noise in the signal during the sensor session.3. The method of claim 2 , further comprising determining a signal strength of the signal from the continuous glucose sensor during the sensor session.4. The method of claim 3 , wherein the one or more noise thresholds are based the signal strength of the signal.5. The method of claim 1 , wherein the output provides an indication of the noise classification to an external device based on the noise classification.6. The method of claim 1 , wherein the output provides an indication of the noise classification on a user interface based on the noise classification.7. The method of claim 1 , ...

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Номер записи: 23
27-09-2012 дата публикации

SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM

Номер: US20120245855A1
Автор:
Принадлежит: DexCom, Inc.

Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as interfering species, ischemia, pH changes, temperatures changes, known or unknown sources of mechanical, electrical and/or biochemical noise, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system processes some or the entire data stream continually or intermittently based at least in part on whether the signal artifact event has occurred. 1. A method for processing data from a glucose sensor , the method comprising:receiving sensor data from a glucose sensor for a time period;evaluating the sensor data to detect signal artifacts; andprocessing the sensor data based on the evaluation.2. The method of claim 1 , wherein the evaluating comprises performing a first derivative analysis.3. The method of claim 1 , wherein the evaluating comprises performing a second derivative analysis.4. The method of claim 1 , wherein the evaluating comprises determining a level of reliability.5. The method of claim 1 , wherein the evaluating comprises determining a confidence interval.6. The method of claim 1 , wherein the processing comprises filtering the sensor data responsive to the evaluation.7. The method of claim 1 , wherein the processing comprises selectively displaying one or more representations of the sensor data based on the evaluation.8. The system of claim 1 , wherein the processing comprises selectively displaying one or more of a representation of raw continuous glucose sensor data claim 1 , a representation of filtered continuous glucose sensor data claim 1 , a representation of a range of data values associated with the continuous glucose sensor data claim 1 , a representation of a direction of the continuous glucose sensor data claim 1 , a representation of a level of confidence of the ...

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Номер записи: 24
11-10-2012 дата публикации

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

Номер: US20120255875A1
Автор: Gauba Indrawati, Vicente Kenneth San, Waichal Siddharth, WALKER Andrew
Принадлежит: DexCom, Inc.

Systems and methods for continuous measurement of an analyte in a host are provided. The system generally includes a continuous analyte sensor configured to continuously measure a concentration of analyte in a host and a sensor electronics module physically connected to the continuous analyte sensor during sensor use, wherein the sensor electronics module is further configured to directly wirelessly communicate sensor information to one or more display devices. Establishment of communication between devices can involve using a unique identifier associated with the sensor electronics module to authenticate communication. Times tracked at the sensor electronics module and the display module can be at different resolutions, and the different resolutions can be translated to facilitate communication. In addition, the frequency of establishing communication channels between the sensor electronics module and the display devices can vary depending upon whether reference calibration information is being updated.

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Номер записи: 25
11-10-2012 дата публикации

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

Номер: US20120258748A1
Автор: Gauba Indrawati, San Vicente Kenneth, Waichal Siddharth, WALKER Andrew
Принадлежит: DexCom, Inc.

Systems and methods for continuous measurement of an analyte in a host are provided. The system generally includes a continuous analyte sensor configured to continuously measure a concentration of analyte in a host and a sensor electronics module physically connected to the continuous analyte sensor during sensor use, wherein the sensor electronics module is further configured to directly wirelessly communicate sensor information to one or more display devices. Establishment of communication between devices can involve using a unique identifier associated with the sensor electronics module to authenticate communication. Times tracked at the sensor electronics module and the display module can be at different resolutions, and the different resolutions can be translated to facilitate communication. In addition, the frequency of establishing communication channels between the sensor electronics module and the display devices can vary depending upon whether reference calibration information is being updated. 1. A method of transmitting data between a first communication device associated with an analyte sensor and a second communication device associated with an analyte value display device , the method comprising:sending messages between the first communication device and the second communication device on a first schedule;requesting an analyte value calibration data point;sending messages between the first communication device and the second communication device on a second schedule more frequent than the first schedule;receiving the analyte value calibration point;calibrating analyte sensor data using the received analyte value calibration point;sending the calibrated analyte sensor data from the first communication device to the second communication device; andresuming sending messages between the first communication device and the second communication device on the first schedule.2. The method of claim 1 , wherein the resuming is responsive to the expiration of a ...

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Номер записи: 26
11-10-2012 дата публикации

SYSTEMS AND METHODS FOR PROCESSING SENSOR DATA

Номер: US20120259191A1
Автор: Dobbles J. Michael, Kamath Apurv Ullas, Mahalingam Aarthi, Shariati Mohammad Ali
Принадлежит: DexCom, Inc.

Systems and methods for processing sensor data are provided. In some embodiments, systems and methods are provided for calibration of a continuous analyte sensor. In some embodiments, systems and methods are provided for classification of a level of noise on a sensor signal. In some embodiments, systems and methods are provided for determining a rate of change for analyte concentration based on a continuous sensor signal. In some embodiments, systems and methods for alerting or alarming a patient based on prediction of glucose concentration are provided. 1. A method for classifying a level of noise in a signal obtained from a continuous glucose sensor based on a signal strength , the method comprising:receiving a signal from a continuous glucose sensor during a sensor session;classifying a level of noise in the signal during the sensor session based on one or more noise thresholds, wherein the one or more noise thresholds are adaptively determined during the sensor session; andcontrolling an output responsive to the noise classification.2. The method of claim 1 , further comprising determining a signal strength of the signal from the continuous glucose sensor during the sensor session.3. The method of claim 2 , wherein the determining a signal strength comprises applying a low pass filter to the signal to determine the signal strength of the signal.4. The method of claim 2 , wherein the classifying comprises adaptively determining the one or more noise thresholds for classification of the level of noise in the signal claim 2 , wherein the one or more noise thresholds are based the signal strength of the signal.5. The method of claim 2 , wherein the one or more noise thresholds are based on a percentage of the signal strength.6. The method of claim 1 , wherein the classifying comprises applying one or more low pass filters to a noise signal to obtain one or more noise indicators and comparing the one or more noise indicators with the one or more noise thresholds.7. ...

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Номер записи: 27
11-10-2012 дата публикации

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

Номер: US20120260323A1
Автор: Gauba Indrawati, San Vicente Kenneth, Waichal Siddharth, WALKER Andrew
Принадлежит: DexCom, Inc.

Systems and methods for continuous measurement of an analyte in a host are provided. The system generally includes a continuous analyte sensor configured to continuously measure a concentration of analyte in a host and a sensor electronics module physically connected to the continuous analyte sensor during sensor use, wherein the sensor electronics module is further configured to directly wirelessly communicate sensor information to one or more display devices. Establishment of communication between devices can involve using a unique identifier associated with the sensor electronics module to authenticate communication. Times tracked at the sensor electronics module and the display module can be at different resolutions, and the different resolutions can be translated to facilitate communication. In addition, the frequency of establishing communication channels between the sensor electronics module and the display devices can vary depending upon whether reference calibration information is being updated. 1. A method for wirelessly exchanging glucose information between a first communication device associated with a continuous glucose sensor and a second communication device associated with a glucose information display device , the method comprising:transmitting a first beacon using the first communication device, the first beacon comprising a first device ID;receiving the first beacon using the second communication device;determining, using the second communication device, if the first device ID transmitted by the first communication device matches a second device ID stored at the second communication device; andexecuting an authentication protocol, using the second communication device, if the second communication device determines that the first device ID matches the second device ID.2. The method of claim 1 , further comprising:receiving user input, using a user interface of the second communication device, comprising an identifier associated with the first ...

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Номер записи: 28
18-10-2012 дата публикации

POPPET VALVE ASSEMBLY FOR CONTROLLING A PNEUMATIC ACTUATOR

Номер: US20120260993A1
Автор: Penning Bruce R.
Принадлежит: General Equipment and Manufacturing Company, Inc., d/b/a TopWorx, Inc.

A poppet valve assembly to control a pneumatic actuator may include a housing having a central bore. A first module may be disposed within the central bore, and the first module may have a first and second poppet valve. A second module may also be disposed within the central bore, and the second module may have a third and fourth poppet valve. A supply of pressurized fluid may be in fluid communication with a plurality of control valves such that pressurized fluid from the control valves opens and closes the poppet valves. The supply of pressurized fluid may also be in fluid communication with the first module and the second module such that the opening and closing of the poppet valves controls the position of the pneumatic actuator. 1. A poppet valve assembly comprising:a valve housing having a central bore;a first module disposed within the central bore, the first module comprising a first normally closed poppet valve and a second normally closed poppet valve, wherein each of the first and second normally closed poppet valves has an open position and a closed position;a central port formed in the first module, wherein the central port of the first module is adapted to be coupled to a first volume of a pneumatic cylinder;an exhaust port formed in the first module such that the central port is in fluid communication with the exhaust port when the first poppet valve is in the open position; anda supply port formed in the first module such that the central port is in fluid communication with the supply port when second poppet valve is in the open position,wherein the supply port is configured to be in fluid communication with a supply of pressurized fluid such that when the second poppet valve is in the open position, pressurized fluid is provided to the first volume of the pneumatic cylinder, andwherein the exhaust port is configured to vent pressurized fluid from the first volume of the pneumatic cylinder when the first poppet valve is in the open position.2. The ...

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Номер записи: 29
18-10-2012 дата публикации

ADVANCED ANALYTE SENSOR CALIBRATION AND ERROR DETECTION

Номер: US20120262298A1
Автор: Bohm Sebastian, Rong Daiting, Simpson Peter C.
Принадлежит: DexCom, Inc.

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors. 1. A method for determining whether an analyte sensor system is functioning properly , the method comprising:applying a stimulus signal to the analyte sensor;measuring a response to the stimulus signal;estimating a value of a sensor property based on the signal response;correlating the sensor property value with a predetermined relationship of the sensor property and a predetermined sensor sensitivity profile.initiating an error routine if the correlation does not exceed a predetermined correlation threshold.2. The method of claim 1 , wherein correlating includes performing a data association analysis.3. The method of claim 1 , wherein the error routine comprises displaying a message to a user indicating that the analyte sensor is not functioning properly.4. The method of claim 1 , wherein the sensor property is an impedance of the sensor membrane.5. A sensor system configured to implement the method of .6. The sensor system of claim 1 , wherein the sensor system comprises instructions stored in computer memory claim 1 , wherein the instructions claim 1 , when executed by one or more processors of the sensor system claim 1 ...

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Номер записи: 30
18-10-2012 дата публикации

ADVANCED ANALYTE SENSOR CALIBRATION AND ERROR DETECTION

Номер: US20120265035A1
Автор: Bohm Sebastian, Rong Daiting, Simpson Peter C.
Принадлежит: DexCom, Inc

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors. 1. A method for calibrating an analyte sensor , the method comprising:applying a time-varying signal to the analyte sensor;measuring a signal response to the applied signal;determining, using sensor electronics, a sensitivity of the analyte sensor, the determining comprising correlating at least one property of the signal response to a predetermined sensor sensitivity profile; andgenerating, using sensor electronics, estimated analyte concentration values using the determined sensitivity and sensor data generated by the analyte sensor.2. The method of claim 1 , wherein the sensitivity profile comprises varying sensitivity values over time since implantation of the sensor.3. The method of claim 1 , wherein the predetermined sensitivity profile comprises a plurality of sensitivity values.4. The method of claim 1 , wherein the predetermined sensitivity profile is based on sensor sensitivity data generated from studying sensitivity changes of analyte sensors similar to the analyte sensor.5. The method of claim 1 , further comprising applying a bias voltage to the sensor claim 1 , wherein the time-varying signal comprises a step ...

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Номер записи: 31
18-10-2012 дата публикации

ADVANCED ANALYTE SENSOR CALIBRATION AND ERROR DETECTION

Номер: US20120265036A1
Автор: Estes Michael J., Kamath Apurv Ullas, Simpson Peter C.
Принадлежит: DexCom, Inc.

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors. 1. A method for calibrating sensor data generated by a continuous analyte sensor , comprising:generating sensor data using a continuous analyte sensor;iteratively determining, with an electronic device, a sensitivity value of the continuous analyte sensor as a function of time by applying a priori information comprising sensor sensitivity information; andcalibrating the sensor data based at least in part on the determined sensitivity value.2. The method of claim 1 , wherein calibrating the sensor data is performed iteratively throughout a substantially entire sensor session.3. The method of claim 1 , wherein iteratively determining a sensitivity value is performed at regular intervals or performed at irregular intervals claim 1 , as determined by the a priori information.4. The method of claim 1 , wherein iteratively determining a sensitivity value is performed throughout a substantially entire sensor session.5. The method of claim 1 , wherein determining a sensitivity value is performed in substantially real time.6. The method of claim 1 , wherein the a priori information is associated with at least one predetermined ...

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Номер записи: 32
18-10-2012 дата публикации

Advanced analyte sensor calibration and error detection

Номер: US20120265037A1
Автор: Daiting Rong, Peter C. Simpson, Sebastian Böhm
Принадлежит: Dexcom Inc

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

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Номер записи: 33
01-11-2012 дата публикации

TRANSCUTANEOUS ANALYTE SENSOR

Номер: US20120277562A1
Автор: Brister Mark, CODD DANIEL SHAWN, Kline Daniel S., McGee Thomas F., Neale Paul V., Petersen David Michael, Petisce James R., SAINT Sean
Принадлежит: DexCom, Inc.

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 1. A transcutaneous system for measuring an analyte concentration in a host , the system comprising:a sensor adapted for transcutaneous placement through a skin of a host, the sensor comprising a first end and a second end;a housing configured to support the sensor during a period of transcutaneous insertion; andan applicator comprising a needle configured for inserting the sensor into the skin of the host; wherein the needle is capable of inserting the first end of sensor into the host, sliding back over the second end of the sensor, and wherein the needle is configured to be released from the housing during the period of continuous transcutaneous insertion, wherein the first end and second end of the sensor are sized to fully reside within the needle.2. The system of claim 1 , further comprising sensor electronics configured to releasably attach to the housing during the period of transcutaneous insertion.3. The system of claim 1 , wherein the time period of transcutaneous insertion is at least about 3 days.4. A transcutaneous system for measuring an analyte concentration in a host claim 1 , the system comprising:a non-planar sensor adapted for transcutaneous placement through a skin of a host, the sensor comprising a first end and a second end; andan applicator comprising a needle configured for inserting the sensor into the skin of the host, wherein the system is configured such that the needle is capable of inserting the first end of sensor into the host, sliding back over the second end of the sensor, and thereby releasing the sensor from the needle, wherein a portion of the second end of the sensor is configured to provide connectivity between the sensor and sensor electronics.5. The system of claim 4 , wherein the non-planar sensor ...

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Номер записи: 34
01-11-2012 дата публикации

SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA FOR SENSOR CALIBRATION

Номер: US20120277566A1
Автор:
Принадлежит: DexCom, Inc.

Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor. 1. A system for calibrating an analyte sensor , comprising:a sensor data receiving module configured to receive sensor data from a first continuous analyte sensor and a second continuous analyte sensor; anda processor module in data communication with the sensor data receiving module, the processor module configured to calibrate the sensor data from the second continuous analyte sensor using the sensor data from the first continuous analyte sensor,wherein the first continuous analyte sensor and the second continuous analyte sensor are identical transcutaneous sensors.2. The system of claim 1 , wherein the first analyte sensor and the second analyte sensor are each glucose sensors.3. The system of claim 1 , wherein the sensor data from the first analyte sensor comprises at least one sensor data point claim 1 , wherein the sensor data from the second analyte sensor comprises at least one sensor data point claim 1 , and wherein calibrating the sensor data from the second continuous analyte sensor further comprises forming at least one matched data pair by matching at least one sensor data point from the first analyte sensor to at least one sensor data point from the second analyte sensor and forming a calibration set comprising at least one matched data pair.4. The system of claim 1 , ...

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Номер записи: 35
08-11-2012 дата публикации

SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA

Номер: US20120283541A1
Автор:
Принадлежит: DexCom, Inc.

Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor. 1. A method for processing data from an analyte sensor , comprising:receiving, with an electronic device, sensor data from an analyte sensor, wherein the sensor data comprises at least one sensor data point;receiving reference data, wherein the reference data comprises at least one reference data point;matching a first reference data point to a substantially time corresponding first sensor data point to form a calibration set;forming a first conversion function based at least in part on the calibration set, wherein the first conversion function comprises a first baseline and a first analyte sensitivity;forming a second conversion function based at least in part on the calibration set, wherein the second conversion function comprises a second baseline and a second analyte sensitivity, wherein at least one attribute of the first conversion function is different from a corresponding attribute of the second conversion function, wherein the at least one attribute is selected from the group consisting of baseline, analyte sensitivity, and combinations thereof; anddetermining an analyte output ...

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Номер записи: 36
08-11-2012 дата публикации

TRANSCUTANEOUS ANALYTE SENSOR

Номер: US20120283543A1
Автор: Brauker James H., Brister Mark, Goode Paul V., Kamath Apurv U.
Принадлежит: DexCom, Inc

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 1. A system for monitoring glucose concentration in a host , the system comprising:a substantially continuous glucose sensor configured to produce sensor data indicative of a glucose concentration in a host;a communications module configured to receive the sensor data from the substantially continuous glucose sensor and to receive reference data from an in vitro single point glucose monitor, the reference data indicative of a measured glucose concentration in a biological sample from the host, wherein the receiver comprises:a processor module; and instructions configured to cause the processor module to determine a rate of change of the glucose concentration in the host at a time corresponding to the measured glucose concentration in the biological sample;', 'instructions configured to cause the processor module to determine a time lag between the sensor data and the reference data based at least in part on the determined rate of change;', 'instructions configured to cause the processor module to form a matched data pair by matching one or more sensor data points of the sensor data with one or more data points of the reference data using the determined time lag; and', 'instructions configured to cause the processor module to calibrate the sensor data, wherein calibrating the sensor data is based at least in part on the matched data pair., 'a computer readable memory comprising2. The system of claim 1 , wherein the instructions configured to cause the processor module to calibrate the sensor data comprise instructions for prospective calibration of the sensor data.3. The system of claim 1 , wherein the instructions configured to cause the processor module to calibrate the sensor data comprise instructions configured to calibrate during ...

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Номер записи: 37
22-11-2012 дата публикации

Integrated delivery device for continuous glucose sensor

Номер: US20120296311A1
Автор: Apurv U. Kamath, Dubravka Markovic, James H. Brauker, Mark A. Tapsak, Michael Robert Mensinger, Paul V. Neale, Peter C. Simpson, Sean T. Saint
Принадлежит: Dexcom Inc

Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

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Номер записи: 38
29-11-2012 дата публикации

SYSTEMS AND METHODS FOR PROCESSING SENSOR DATA

Номер: US20120302854A1
Автор: Dobbles John Michael, Kamath Apurv Ullas, LI Ying, Mahalingam Aarthi, Mensinger Michael Robert
Принадлежит: DexCom, Inc.

Systems and methods for processing sensor data are provided. In some embodiments, systems and methods are provided for calibration of a continuous analyte sensor. In some embodiments, systems and methods are provided for classification of a level of noise on a sensor signal. In some embodiments, systems and methods are provided for determining a rate of change for analyte concentration based on a continuous sensor signal. In some embodiments, systems and methods for alerting or alarming a patient based on prediction of glucose concentration are provided. 1. A method for calibration of a continuous glucose sensor , the method comprising:receiving sensor data from a continuous analyte sensor, the sensor data comprising one or more sensor data points;receiving and processing calibration information;evaluating a predictive accuracy of the calibration information; andprocessing the sensor data based on the predictive accuracy.2. The method of claim 1 , wherein the processing comprises determining a time period before requesting additional reference data.3. The method of claim 2 , wherein the time period is between about 0 minutes and 7 days.4. The method of claim 2 , further comprising displaying the time period before reference data will be requested.5. The method of claim 1 , wherein the receiving and processing calibration information comprises receiving a matched data pair and forming a calibration set including the matched data pair claim 1 , and wherein the evaluating a predictive accuracy comprises evaluating a discordance of the matched data pair and/or the matched data pairs in the calibration set.6. The method of claim 1 , wherein the receiving and processing calibration information comprises receiving reference data claim 1 , and wherein the evaluating a predictive accuracy comprises evaluating a leverage of the reference data based at least in part on a glucose concentration associated with the reference data.7. The method of claim 1 , wherein the processing ...

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Номер записи: 39
29-11-2012 дата публикации

SYSTEMS AND METHODS FOR PROCESSING SENSOR DATA

Номер: US20120302855A1
Автор: Dobbles John Michael, Kamath Apurv Ullas, LI Ying, Mahalingam Aarthi, Mensinger Michael Robert
Принадлежит: DexCom, Inc.

Systems and methods for processing sensor data are provided. In some embodiments, systems and methods are provided for calibration of a continuous analyte sensor. In some embodiments, systems and methods are provided for classification of a level of noise on a sensor signal. In some embodiments, systems and methods are provided for determining a rate of change for analyte concentration based on a continuous sensor signal. In some embodiments, systems and methods for alerting or alarming a patient based on prediction of glucose concentration are provided. 1. A method for calibration of a continuous glucose sensor , the method comprising:receiving a signal from a continuous glucose sensor;evaluating a sensor performance during a sensor session by determining an amount of drift on the signal over a period of time, wherein determining the amount of drift comprises monitoring a change in calibration information; andprocessing the signal based on the sensor performance.2. The method of claim 1 , wherein the calibration information comprises one or more matched data pairs claim 1 , a calibration set and/or a calibration line.3. The method of claim 1 , wherein the processing comprises determining when to request reference data responsive to the sensor performance determined.4. The method of claim 1 , wherein the processing comprises diagnosing a sensor condition.5. The method of claim 1 , wherein the processing comprises controlling alarms indicative of at least one of hypoglycemia claim 1 , hyperglycemia claim 1 , predicted hypoglycemia claim 1 , or predicted hyperglycemia based on the predictive accuracy.6. The method of claim 1 , wherein the processing comprises controlling insulin delivery and/or insulin therapy instructions based on the predictive accuracy.7. The method of claim 1 , wherein the processing comprises diagnosing a sensor condition based at least in part on the predictive accuracy.8. A system for processing continuous glucose sensor data claim 1 , the ...

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Номер записи: 40
20-12-2012 дата публикации

Systems and methods for replacing signal artifacts in a glucose sensor data stream

Номер: US20120323100A1
Автор: Aarthi Mahalingam, Apurv Kamath, James H. Brauker, Ying Li
Принадлежит: Dexcom Inc

Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as interfering species, ischemia, pH changes, temperatures changes, known or unknown sources of mechanical, electrical and/or biochemical noise, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system processes some or the entire data stream continually or intermittently based at least in part on whether the signal artifact event has occurred.

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Номер записи: 41
03-01-2013 дата публикации

VALVE SIGNATURE DIAGNOSIS AND LEAK TEST DEVICE

Номер: US20130000753A1
Автор: LaFountain Robert L., Li Jingli, Penning Bruce R., Rigsby Bruce
Принадлежит: General Equipment and Manufacturing Company, Inc., d/b/a TopWorx, Inc.

A valve signature diagnosis and leak testing device includes a spool valve operatively connected to a pilot valve, the pilot valve being configured to position the spool valve to one of an open position and a closed position. A blocker valve is fluidly connected to a control fluid outlet of the spool valve. An electrical module is operatively connected to the pilot valve, a supply of control fluid, and the blocker valve, the electrical module being capable of sending pulsed electrical signals to the pilot valve and the blocker valve to selectively position the spool valve and the blocker valve to an open or closed position. 1. A valve signature diagnosis and leak testing device for a control valve , the valve signature diagnosis and leak testing device comprising:a spool valve operatively connected to a pilot valve, the pilot valve being configured to position the spool valve to one of an open position and a closed position, the spool valve including a first control fluid inlet, a first control fluid outlet, and a second control fluid outlet, the first control fluid inlet being fluidly connected to a supply of control fluid and the first control fluid outlet being configured to be connected to a valve actuator;a blocker valve fluidly connected to the second control fluid outlet; andan electrical module operatively connected to the pilot valve, the supply of control fluid, and the blocker valve, the electrical module being capable of sending pulsed electrical signals to the pilot valve and the blocker valve to selectively position the spool valve and the blocker valve to an open or a closed position,wherein the open position of the spool valve fluidly connects the first control fluid inlet to the first control fluid outlet and the closed position of the spool valve fluidly connects the first control fluid outlet to the second control fluid outlet.2. The valve signature diagnosis and leak testing device of claim 1 , wherein the electrical module includes a main ...

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Номер записи: 42
10-01-2013 дата публикации

TRANSCUTANEOUS ANALYTE SENSOR

Номер: US20130012798A1
Автор:
Принадлежит: DexCom, Inc.

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 1. A system for inserting an analyte sensor into a host , comprising: the analyte sensor;', 'a housing configured to receive the analyte sensor and to maintain the analyte sensor in the host after insertion; and', 'an applicator configured to releasably connect with the housing, wherein the applicator comprises a trigger, and wherein the applicator is configured to insert the analyte sensor into the host and to automatically release the applicator from the housing responsive to activation of the trigger., 'an assembly configured to insert an analyte sensor into a host, wherein the assembly comprises2. The system of claim 1 , wherein the housing comprises an adhesive pad located on an underside of the housing and is configured to adhere the housing to the host's skin.3. The system of claim 2 , wherein the assembly is configured such that the housing must be adhered to the host's skin prior to sensor insertion.4. The system of claim 1 , further comprising an electronics unit configured to releasably mate with the housing.5. The system of claim 4 , wherein the electronics unit is configured to slide-fit into a recess in the housing before sensor insertion.6. The system of claim 4 , wherein the electronics unit is configured to releasably mate with at least a portion of the housing before sensor insertion.7. The system of claim 1 , further comprising a safety mechanism configured such that it must be released prior to sensor insertion.8. The system of claim 1 , wherein the assembly further comprises a needle configured to carry at least a portion of the analyte sensor into the host and to subsequently remove the needle from the host thereby leaving the analyte sensor inserted in the host.9. A system for inserting an analyte sensor into a host claim 1 ...

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Номер записи: 43
24-01-2013 дата публикации

WIRELESS MONITORING AND CONTROL OF SAFETY STATIONS IN A PROCESS PLANT

Номер: US20130021167A1
Автор: Harper, JR. Ronald D.
Принадлежит: General Equipment and Manufacturing Company, Inc., d/b/a TopWorx, Inc.

A safety station for use in a process plant includes one or more leverless limit switches to detect activation of one or more parts of the safety station. The safety station further includes a wireless transmitter coupled to the leverless limit switches to transmit signals associated with the safety station to a base station device, which is communicatively coupled to one or more control and/or monitoring devices. 1. A safety station for use in a process plant , the safety station comprising:one or more leverless limit switches to detect activation of one or more parts of the safety station; anda wireless transmitter coupled to the leverless limit switches to transmit signals associated with the safety station to a base station device, wherein the base station device is communicatively coupled to one or more control and/or monitoring modules.2. The safety station of claim 1 , wherein the leverless limit switch is a GO® switch manufactured by the TopWorx corporation.3. The safety station of claim 1 , wherein the leverless limit switch remains latched until physically reset.4702. The safety station of claim 1 , wherein the wireless transmitter is the Rosemount dual input transmitter manufactured by the Emerson corporation.5. The safety station of claim 1 , wherein the wireless transmitter is an intrinsically safe wireless transmitter.6. The safety station of claim 1 , wherein the safety station is a safety shower and/or an eye wash station.7. The safety station of claim 1 , wherein at least one of the one or more control and/or monitoring stations is a remote touch screen panel.8. The safety station of claim 1 , wherein at least one of the one or more control and/or monitoring stations is a paperless recorder.9. The safety station of claim 1 , wherein at least one of the one or more control and/or monitoring stations is a workstation.10. A safety station monitoring and control system in a process plant claim 1 , the system comprising:one or more safety stations ...

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Номер записи: 44
31-01-2013 дата публикации

SWITCH MODULE

Номер: US20130027831A1
Автор: Penning Bruce R.
Принадлежит: General Equipment and Manufacturing Company, Inc., d/b/a TopWorx, Inc.

A switch module used for position sensing may be operated in a number of modes for compatibility with a number of legacy position sensing products. A dry switch circuit can be configured to provide a direct output, emulating dry reed, high-side or low-side switched configurations. Alternatively, the dry switch circuit can be connected to an input of a NAMUR circuit to provide the known current output for that standard. In another configuration the dry switch can be selectively coupled to one of two NAMUR circuits allowing the switch module to provide a low-to-high current NAMUR output or a high-to-low current NAMUR output. 1. A switch module arranged and adapted to report a position of a moveable element external to the switch module , the switch module comprising:a first external connection, a second external connection, and a third external connection;a dry contact relay having a relay contact position responsive to a position of a component external to the switch module, the dry contact relay having a common connection, a normally open connection and a normally closed connection, where the normally open connection corresponds to a first position of the moveable element and the normally closed connection corresponding to a second position of the moveable;a NAMUR circuit having a first input connection pair and a first output connection pair;an electrical connection from the normally open connection of the dry relay to a first input of the first input connection pair of the NAMUR circuit;a selector operable to connect the common connection of the dry contact relay to i) a null contact of the selector or ii) a second input of the first input connection pair of the NAMUR circuit;a second electrical connection from the first output of the NAMUR circuit to one of the first external connection or the second external connection; anda third electrical connection between the second output of the NAMUR circuit to the third external connection;a first jumper that removeably ...

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Номер записи: 45
31-01-2013 дата публикации

TECHNIQUES TO IMPROVE POLYURETHANE MEMBRANES FOR IMPLANTABLE GLUCOSE SENSORS

Номер: US20130030273A1
Автор: McClure Jason D., Rhodes Rathbun K., Shults Mark C., Tapsak Mark A.
Принадлежит: DexCom, Inc.

The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor. 1. A method for preparing an implantable homogeneous membrane , the method comprising:forming a composition comprising a dispersion of a hydrophobic-hydrophilic copolymer within a matrix of a hydrophobic polymer;maintaining the composition at a temperature sufficient to maintain solubility of the hydrophobic-hydrophilic copolymer and the hydrophobic polymer;applying the composition at the temperature to at least one of a substrate or a layer on the substrate to form a film thereon; anddrying the film to form a membrane.2. The method of claim 1 , wherein forming a composition comprises forming a mixture or a blend.3. The method of claim 1 , wherein maintaining the composition at the temperature comprises heating the composition at a temperature of about 70° C.4. The method of claim 1 , wherein the drying the film comprises drying at a temperature of from about 120° C. to about 150° C.5. The method of claim 1 , wherein the hydrophobic-hydrophilic copolymer comprises a hydrophilic component comprising polyethylene oxide.6. The method of claim 1 , wherein the hydrophobic polymer comprises polyurethane.7. The method of claim 1 , wherein the membrane has an oxygen-to-glucose permeability ratio of approximately 200:1.8. The method of claim 1 , wherein the substrate comprises an electrode of a continuous analyte sensor.9. The method of claim 8 , wherein the continuous analyte ...

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Номер записи: 46
07-02-2013 дата публикации

SYSTEMS AND METHODS FOR DETECTING GLUCOSE LEVEL DATA PATTERNS

Номер: US20130035575A1
Автор: Boock Robert J., Bowman Leif N., Hampapuram Hari, Kamath Apurv Ullas, Mayou Phil, Mensinger Michael Robert, Price David, Reihman Eli, Simpson Peter C., Snisarenko Kostyantyn, Weindel Keri
Принадлежит: DexCom, Inc.

Systems and methods for detecting and reporting patterns in analyte concentration data are provided. According to some implementations, an implantable device for continuous measurement of an analyte concentration is disclosed. The implantable device includes a sensor configured to generate a signal indicative of a concentration of an analyte in a host, a memory configured to store data corresponding at least one of the generated signal and user information, a processor configured to receive data from at least one of the memory and the sensor, wherein the processor is configured to generate pattern data based on the received information, and an output module configured to output the generated pattern data. The pattern data can be based on detecting frequency and severity of analyte data in clinically risky ranges. 1. An analyte concentration monitoring system , comprising:a display screen;one or more processors;an input module configured to receive sensor data from an analyte sensor configured to generate sensor data points indicative of a measured an analyte concentration;memory; and instructions to apply a weighted value to each sensor data point falling within a timeframe of sensor data, the weighted value depending upon a concentration value of the sensor data;', 'instructions to aggregate the weighted sensor data according to time of day; and', 'instructions to display the aggregated, weighted sensor data on a chart., 'one or more programs, wherein the one or more programs are stored in the memory and are configured to be executed by the one or more processors, the one or more programs including2. The system of claim 1 , wherein aggregating the sensor data according to time of day includes aggregating each sensor data point that falls within the same five minute interval of a day.3. The system of claim 1 , further comprising instructions to highlight significant time ranges of the displayed sensor data claim 1 , wherein significant time ranges of displayed data ...

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Номер записи: 47
07-02-2013 дата публикации

SYSTEMS AND METHODS FOR DETECTING GLUCOSE LEVEL DATA PATTERNS

Номер: US20130035865A1
Автор: Boock Robert J., Bowman Leif N., Hampapuram Hari, Kamath Apurv Ullas, Mayou Phil, Mensinger Michael Robert, Price David, Reihman Eli, Simpson Peter C., Snisarenko Kostyantyn, Weindel Keri
Принадлежит: DexCom, Inc.

Systems and methods for detecting and reporting patterns in analyte concentration data are provided. According to some implementations, an implantable device for continuous measurement of an analyte concentration is disclosed. The implantable device includes a sensor configured to generate a signal indicative of a concentration of an analyte in a host, a memory configured to store data corresponding at least one of the generated signal and user information, a processor configured to receive data from at least one of the memory and the sensor, wherein the processor is configured to generate pattern data based on the received information, and an output module configured to output the generated pattern data. The pattern data can be based on detecting frequency and severity of analyte data in clinically risky ranges. 1. An analyte monitoring system configured to measure an analyte concentration of a host , the system comprising:a sensor configured to generate sensor data indicative of a concentration of an analyte in a host over time;a memory configured to store the sensor data;a processor configured to receive the sensor data from at least one of the memory and detecting a pattern in the data, the detecting comprising identifying a plurality of events based on the sensor data, associating at least some of the plurality of events based on a criterion to from a set of events, and qualifying the set of events as the detected pattern; andan output module configured to output information representative of the detected pattern.2. The system of claim 1 , wherein the criterion is a timeframe.3. The system of claim 1 , wherein qualifying the set of events as a pattern comprises determining a priority score associated with the set.4. The system of claim 3 , wherein the set qualifies as a pattern if the priority score exceeds a threshold.5. The system of claim 3 , wherein the associating includes forming a plurality of sets claim 3 , and wherein the set qualifies as a pattern if ...

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Номер записи: 48
07-02-2013 дата публикации

SYSTEMS AND METHODS FOR DETECTING GLUCOSE LEVEL DATA PATTERNS

Номер: US20130035871A1
Автор: Boock Robert J., Bowman Leif N., Hampapuram Hari, Kamath Apurv Ullas, Mayou Phil, Mensinger Michael Robert, Price David, Reihman Eli, Simpson Peter C., Snisarenko Kostyantyn, Weindel Keri
Принадлежит: DexCom, Inc.

Systems and methods for detecting and reporting patterns in analyte concentration data are provided. According to some implementations, an implantable device for continuous measurement of an analyte concentration is disclosed. The implantable device includes a sensor configured to generate a signal indicative of a concentration of an analyte in a host, a memory configured to store data corresponding at least one of the generated signal and user information, a processor configured to receive data from at least one of the memory and the sensor, wherein the processor is configured to generate pattern data based on the received information, and an output module configured to output the generated pattern data. The pattern data can be based on detecting frequency and severity of analyte data in clinically risky ranges. 1. A method for alerting a user based on measurements of an analyte concentration , the method comprising:receiving data from at least one input, the data including measurements of an analyte concentration and time of day information;analyzing the received data;detecting a hypoglycemic event based on the data exceeding at least one predetermined threshold; anddisplaying a trend graph of glucose measurements over time on a user interface, wherein the trend graph includes an indication of a hypoglycemic reoccurrence risk associated with a predetermined amount of time following the detected hypoglycemic event.2. The method of claim 1 , wherein detecting the hypoglycemia event comprises determining an average distance and a time a segment of time the measured analyte concentration is below a predetermined analyte concentration level.31. The method of claim 1 , wherein the method of claim C is performed only when a user-selectable setting is turned on.4. The method of claim 1 , wherein the predetermined amount of time is 48 hours.5. The method of claim 1 , further comprising triggering an audible or visual alert using the user interface responsive to detecting ...

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Номер записи: 49
28-02-2013 дата публикации

POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS

Номер: US20130053665A1
Автор: Boock Robert J., Dring Chris W., Hughes Jonathan
Принадлежит: DexCom, Inc.

Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the devices include a membrane that has an interference domain designed to reduce the permeation of one or more interferents. 1. An implantable device for continuous measurement of an analyte concentration , the implantable device comprising:a sensor configured to generate a signal indicative of a concentration of an analyte in a host; anda membrane located over the sensor, the membrane comprising a first domain configured to reduce a flux therethrough of the analyte, a second domain that comprises an enzyme, and a third domain configured to reduce passage therethrough of an interferent, the third domain comprising a plurality of alternating polyelectrolyte layers.2. The implantable device of claim 1 , wherein the plurality of alternating polyelectrolyte layers of the third domain comprise two types of layers.3. The implantable device of claim 2 , wherein the two types of layers comprise a polycationic layer and a polyanionic layer.4. The implantable device of claim 3 , wherein polycationic layers form the most distal layer and the most proximal layer of the third domain with respect to the sensor.5. The implantable device of claim 4 , wherein the third domain comprises an odd number of alternating polyelectrolyte layers.6. The implantable device of claim 5 , wherein the third domain comprises at least three alternating polyelectrolyte layers.7. The implantable device of claim 6 , wherein the first and third most distal layers with respect to the sensor are polycationic layers claim 6 , and wherein the second most distal layer with respect to the sensor is a polyanionic layer.8. The implantable device of claim 5 , wherein the third domain comprises at least five alternating polyelectrolyte layers.9. The implantable device of claim 8 , wherein the first claim 8 , third claim 8 , and fifth most distal layers with respect to the sensor are ...

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Номер записи: 50
28-02-2013 дата публикации

POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS

Номер: US20130053666A1
Автор: Boock Robert J., Dring Chris W., Hughes Jonathan
Принадлежит: DexCom, Inc.

Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the devices include a membrane that has an interference domain designed to reduce the permeation of one or more interferents. 1. A method for forming a membrane on an implantable device configured for continuous measurement of an analyte concentration , comprising:applying a first solution to an implantable sensor or a layer deposited thereon, the first solution having a first pH and comprising polycations;drying the first solution to form a polycationic layer;applying a second solution to the polycationic layer, the second solution having a second pH and comprising polyanions; anddrying the second solution to form a polyanionic layer.2. The method of claim 1 , wherein the first pH is approximately the pKof the polycations.3. The method of claim 1 , wherein the first pH is from about 9 to 10.4. The method of claim 1 , wherein the second pH is approximately the pKof the polyanions.5. The method of claim 1 , wherein the pH is from about 2 to 3.6. The method of claim 1 , further comprising applying a solution comprising an enzyme onto at least one of a polycationic layer or a polyanionic layer to form an enzyme layer.7. The method of claim 5 , wherein the analyte is glucose claim 5 , and wherein the enzyme is glucose oxidase.8. An implantable device for continuous measurement of glucose concentration claim 5 , the device comprising:an electrode configured to generate a signal indicative of a concentration of glucose in a host; and a first domain that comprises an enzyme configured to react with glucose;', 'a second domain configured to reduce passage therethrough of an interferent, the second domain comprising a plurality of alternating polyelectrolyte layers, wherein the plurality of alternating polyelectrolyte layers comprise at least one of a polycationic layer and a polyanionic layer., 'a membrane located over the electrode, the membrane ...

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Номер записи: 51
07-03-2013 дата публикации

SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA FOR SENSOR CALIBRATION

Номер: US20130060112A1
Автор: Brauker James H., Goode Paul V., Kamath Apurv Ullas, Pryor Jack
Принадлежит: DexCom, Inc.

Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor. 1. A method for calibrating a continuous analyte sensor , comprising:receiving sensor data from a continuous analyte sensor, wherein the sensor data is indicative of a glucose concentration in a host;determining a conversion function, using a processor module, wherein the conversion function comprises a slope and a baseline, wherein the slope is representative of a sensor sensitivity, and wherein at least one of the slope or the baseline is determined based on prior distribution information; andconverting the sensor data using the conversion function.2. The method of claim 1 , wherein determining the conversion function comprises determining the slope based on prior slope distribution information.3. The method of claim 2 , wherein determining the slope comprises selecting a most probable slope from a distribution of slopes based on the prior slope distribution information.4. The method of claim 1 , wherein determining the conversion function comprises determining the baseline based on prior baseline distribution information.5. The method of claim 2 , wherein determining the baseline comprises selecting a most probable baseline from a distribution of baselines based on the prior baseline distribution information.6. The method of claim 1 , wherein determining the conversion function ...

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Номер записи: 52
28-03-2013 дата публикации

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

Номер: US20130076531A1
Автор: Grubstein Katherine Yerre, Hampapuram Hari, Leach Jacob S., Reihman Eli, San Vicente Kenneth
Принадлежит: DexCom, Inc.

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are provided. The data can be displayed on a hand-held display device having a display such as a key fob device including a user interface, such as an LCD and one or more buttons that allows a user to view data, and a physical connector, such as USB port. 1. A method for transmitting data between a first communication device associated with an analyte sensor and a primary communication device and a secondary communication device configured to provide user access to analyte values and/or information derived from analyte values , comprising:establishing a communication channel between a secondary communication device and a first communication device during a transmission time window of a sensor session;determining whether a primary communication device has previously been in communication with the first communication device during the sensor session; andrejecting requests for data or commands sent by the secondary communication device to the first communication device if the primary communication device has not been in communication with the first device during the sensor session.2. The method of claim 1 , wherein the communication between the primary communication device and the first communication device comprises control information for initiating a sensor session.3. A system for monitoring an analyte level of a host claim 1 , the system configured to perform the method of claim 1 , wherein the first communication device comprises a sensor electronics module claim 1 , the sensor electronics module configured to electronically couple to an analyte sensor and to generate an analyte data stream using the analyte sensor.4. A method of transmitting data between a first communication device associated with an analyte sensor and a primary communication device and a secondary communication device claim 1 , each of the primary communication device ...

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Номер записи: 53
28-03-2013 дата публикации

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

Номер: US20130076532A1
Автор: Grubstein Katherine Yerre, Hampapuram Hari, Leach Jacob S., Reihman Eli, San Vicente Kenneth
Принадлежит: DexCom, Inc.

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are provided. The data can be displayed on a hand-held display device having a display such as a key fob device including a user interface, such as an LCD and one or more buttons that allows a user to view data, and a physical connector, such as USB port. 1. A method for transmitting data between a first communication device associated with an analyte sensor and one or more second communication devices configured to provide user access to analyte values and/or information derived from analyte values , comprising:establishing a communication channel only with a primary device of a one or more second communication devices during a first time period within a communication window; andestablishing a communication channel with one or more secondary devices of the one or more second communication devices only during a second time period different from the first time period.2. A system for monitoring an analyte level of a host configured to perform the method of claim 1 , comprising a sensor electronics module configured to establish a communication channel with a primary device and establishing the communication channel with one or more secondary devices.3. A method for synchronizing a time for transmitting data between a first communication device associated with an analyte sensor and a primary communication device and a secondary communication device configured to provide user access to analyte values and/or information derived from analyte values claim 1 , the method comprising:receiving a beacon from a first communication device at a primary communication device during a transmission time window defined by the first communication device;establishing a first communication channel between the primary communication device and a secondary communication device;transmitting beacon information from the primary communication device to the secondary ...

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Номер записи: 54
28-03-2013 дата публикации

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

Номер: US20130078912A1
Автор: Grubstein Katherine Yerre, Hampapuram Hari, Leach Jacob S., Reihman Eli, San Vicente Kenneth
Принадлежит: DexCom, Inc.

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are provided. The data can be displayed on a hand-held display device having a display such as a key fob device including a user interface, such as an LCD and one or more buttons allows a user to view data, and a physical connector, such as USB port. 1. A method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to analyte values and/or information derived from analyte values , comprising:activating a transceiver of a first communication device associated with an analyte sensor at a first time;establishing a two-way communication channel with the second communication device using an authentication scheme;sending analyte sensor data to the second communication device using the two-way communication channel;deactivating the transceiver of the first communication device at a second time; andperiodically repeating the activating, establishing, sending and deactivating, wherein a difference between the first time and the second time is less than or equal to one minute, and wherein the periodic repeating is performed at least once every 30 minutes.2. The method of claim 1 , wherein activating comprises supplying power to the transceiver claim 1 , and wherein deactivating comprises powering down the transceiver.3. The method of claim 1 , wherein activating comprises waking the transceiver from a low power sleep mode claim 1 , and wherein deactivating the transceiver comprises placing the transceiver into a lower power sleep mode.4. The method of claim 1 , further comprising closing the two-way communication channel before deactivating the transceiver.5. The method of claim 1 , wherein the difference between the first time and second time corresponds to a transmission time window claim 1 , and wherein the analyte sensor data corresponds to ...

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Номер записи: 55
16-05-2013 дата публикации

ANALYTE SENSOR

Номер: US20130123596A1
Автор: Brister Mark, Kamath Apurv Ullas, Leach Jacob S., LI Ying, Rong Daiting, SAINT Sean, Simpson Peter C.
Принадлежит: DexCom, Inc.

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system. 119-. (canceled)20. A method for processing continuous analyte sensor data , the method comprising:placing a continuous analyte sensor in fluid communication with a circulatory system of a host, wherein a sensor system comprises the sensor and sensor electronics, wherein the sensor is configured to generate a signal associated with an in vivo analyte concentration when the sensor is implanted in the host,exposing the sensor to a sample from the host's circulatory system;providing a fail-safe module comprising a processor for executing computer program code stored in memory to cause the processor to:perform a steady state analysis and a transient analysis of the signal;evaluate a relationship between the steady state analysis and the transient analysis; anddetect a malfunction of the system.21. The method of claim 20 , further comprising generating a signal associated with glucose.22. The method of claim 20 , wherein the detecting step further comprises detecting an electrical malfunction.23. The method of claim 20 , wherein the detecting step further comprises detecting a fluidics malfunction.24. The method of claim 20 , wherein the placing step further comprises inserting a vascular access device into the host's circulatory system.25. The method of claim 24 , wherein the placing step further comprises fluidly coupling the sensor to the vascular access device.26. The method of claim 20 , wherein the detecting step further comprises detecting a sensor malfunction.27. The method of claim 20 , wherein the detecting step further comprises performing a waveform analysis of the signal.28. The method of claim 20 , wherein the detecting step further ...

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Номер записи: 56
23-05-2013 дата публикации

ANALYTE SENSOR

Номер: US20130131469A1
Автор: Brister Mark, Leach Jacob S., Simpson Peter C.
Принадлежит: DexCom, Inc.

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system. 121-. (canceled)22. A method for detecting a fluidics malfunction of an analyte sensor system in a circulatory system of a host , the method comprising:providing an apparatus comprising an external surface, a first orifice and a second orifice, wherein at least one of the first orifice and the second orifice is configured to couple with a fluid flow device; a lumen, at least one sensor disposed within the lumen of the apparatus;contacting the at least one sensor with a plurality of samples from the circulatory system of a host; andgenerating a signal from each of the at least one sensors for the plurality of samples;monitoring a pattern of signal increases or decreases generated from each of the at least one sensor from the plurality of samples; anddetecting a fluidics malfunction.23. The method of claim 22 , further comprising processing the signals from each of the sensors.24. The method of claim 22 , wherein the generating step comprises at least one of electrochemically generating claim 22 , optically generating claim 22 , radiochemically generating claim 22 , physically generating claim 22 , chemically generating claim 22 , immunochemically generating claim 22 , and enzymatically generating a signal from each of the plurality of sensors.25. The method of claim 22 , further comprising reinfusing the withdrawn sample into the host.2621. The method of claim claim 22 , further comprising washing the sensors with an infusion fluid.2721. The method of claim claim 22 , further comprising calibrating the signal of at least one of the sensors. This application is a continuation-in-part of U.S. application Ser. No. 11/691,466 filed Mar. 26, 2007; ...

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Номер записи: 57
23-05-2013 дата публикации

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Номер: US20130131478A1
Автор: Boock Robert J., Brister Mark C., Brunner Seth R., Chee Arthur, Markovic Dubravka, Nguyen Lisa, Nicholas Melissa A., Petisce James R., Pryor Jack, Rixman Monica A., Simpson Peter C., Wightlin Matthew D., Woo Kum Ming
Принадлежит: DexCom, Inc.

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 1. An electrochemical continuous glucose sensor configured for implantation in a host , the glucose sensor comprising:an electrode configured to measure a signal indicative of a glucose concentration of a host, wherein the signal comprises a glucose-related component and a non-glucose related component; anda membrane covering at least a portion of the electrode, wherein the membrane is configured to reduce passage of an interfering species therethrough, whereby the non-glucose-related component of the signal is less than about 20% of the signal over a period of at least one day;wherein the glucose sensor has a sensitivity to glucose of from about 25 pA/mg/dL to about 500 pA/mg/dL.2. The glucose sensor of claim 1 , wherein the interfering species has an oxidation potential that overlaps with an oxidation potential of a measured species indicative of the concentration of the analyte.3. The glucose sensor of claim 1 , wherein the measured species is a product of an enzymatic reaction between glucose and an enzyme and is measured by the electrode.4. The glucose sensor of claim 1 , wherein the membrane comprises a silicone-containing polymer.5. The glucose sensor of claim 4 , wherein the silicone-containing polymer is a polysiloxanes.6. The glucose sensor of claim 4 , wherein the silicone-containing polymer is a polycarbosiloxane.7. The glucose sensor of wherein the silicone-containing polymer is a copolymer comprising a silicone segment and a polyurethane segment.8. The glucose sensor of claim 1 , wherein the membrane comprises a fluorocarbon-based material.9. The glucose sensor of claim 1 , wherein the non-glucose-related component ...

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Номер записи: 58
13-06-2013 дата публикации

SYSTEMS AND METHODS FOR PROCESSING SENSOR DATA

Номер: US20130150692A1
Автор: Dobbles John Michael, Kamath Apurv Ullas, Mahalingam Aarthi
Принадлежит: DexCom, Inc.

Systems and methods for processing sensor data are provided. In some embodiments, systems and methods are provided for calibration of a continuous analyte sensor. In some embodiments, systems and methods are provided for classification of a level of noise on a sensor signal. In some embodiments, systems and methods are provided for determining a rate of change for analyte concentration based on a continuous sensor signal. In some embodiments, systems and methods for alerting or alarming a patient based on prediction of glucose concentration are provided. 1. A method for generating analyte measurements of a host , the method comprising:generating sensor data during a first time period using an analyte sensor coupled to a sensor electronics unit, wherein the sensor electronics unit is adhered to a body of a host;receiving, using a receiver in wireless communication with the sensor electronics unit, a reference analyte value generated by a reference analyte monitor;responsive to receiving the reference analyte value, determining a first estimated analyte concentration value to display using a first algorithm, wherein determining the first estimated analyte concentration to display includes using the reference analyte value in a first algorithm;determining a second estimated analyte concentration value to display using the reference analyte value and the sensor data for the first time period in a second algorithm that is different from the first algorithm; anddisplaying, on a display of the receiver, a numerical analyte value selected from the first estimated analyte value and the second estimated analyte value, wherein the first estimated analyte concentration value is selected as the displayed numerical value until the second estimated analyte concentration is available, and subsequently selecting the second estimated analyte concentration value to be the displayed numerical value.2. The method of claim 1 , wherein the sensor data for the first time period is not used ...

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Номер записи: 59
27-06-2013 дата публикации

Analyte Sensor

Номер: US20130165756A1
Автор: Brister Mark, Kamath Apurv U., Simpson Peter C.
Принадлежит: DexCom, Inc.

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system. 1. A method for measuring an analyte in a host , comprising:exposing a continuous analyte detection system to a sample, wherein the continuous analyte detection system comprises a continuous analyte sensor configured for contact with a sample from a circulatory system of a host in vivo and configured to generate a first signal associated with a test analyte and a second signal associated with a reference analyte, and a reference sensor configured to generate a reference signal associated with the reference analyte;receiving the first signal, the second signal, and the reference signal;calculating a calibration factor associated with a sensitivity of the continuous analyte sensor; andcalibrating the first signal, wherein calibrating comprises using the calibration factor.2. The method of claim 1 , wherein the exposing step further comprises simultaneously exposing the continuous analyte sensor and the reference sensor to the sample.3. The method of claim 1 , wherein the receiving step further comprises receiving the first signal from a first working electrode disposed under an enzymatic portion of a membrane system.4. The method of claim 3 , wherein the receiving step further comprises receiving the second signal from the first working electrode.5. The method of claim 3 , wherein the receiving step further comprises receiving the second signal from a second working electrode disposed under the membrane system.7. The method of claim 5 , wherein the receiving step further comprises receiving a non-analyte-related signal from a third working electrode disposed under a non-enzymatic portion of the membrane system.8. The method of claim 1 , wherein ...

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Номер записи: 60
05-09-2013 дата публикации

DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR

Номер: US20130231542A1
Автор: Brister Mark, Pryor Jack, Simpson Peter C., Wightlin Matthew
Принадлежит: DexCom, Inc.

Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data. 1. A continuous glucose sensor configured and arranged for insertion into a host for and detecting glucose in the host , the sensor comprising:a first working electrode comprising a first resistance domain, wherein the first working electrode is configured to generate a first signal having a first noise component related to a noise-causing species;a second working electrode comprising a second resistance domain, wherein the second working electrode is configured to generate a second signal having a second noise component related to the noise-causing species; anda third resistance domain disposed continuously over the first resistance domain and the second resistance domain.2. The sensor of claim 1 , wherein the noise-causing species comprises at least one member selected from the group consisting of externally produced HO claim 1 , urea claim 1 , lactic acid claim 1 , phosphates claim 1 , citrates claim 1 , peroxides claim 1 , amino acids claim 1 , amino acid precursors claim 1 , amino acid break-down products claim 1 , nitric oxide claim 1 , NO-donors claim 1 , NO-precursors claim 1 , reactive oxygen species claim 1 , compounds having electroactive acidic claim 1 , amine or sulfhydryl groups claim 1 , acetaminophen claim 1 , ascorbic acid claim 1 , dopamine claim 1 , ephedrine claim 1 , ibuprofen claim 1 , L-dopa claim 1 , methyldopa claim 1 , salicylate claim 1 , tetracycline claim 1 , tolazamide claim 1 , tolbutamide claim 1 , and triglycerides.3. The sensor of claim 1 , wherein the noise-causing species is non-constant.4. The ...

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Номер записи: 61
12-09-2013 дата публикации

System and methods for processing analyte sensor data

Номер: US20130237786A1
Автор: Apurv Ullas Kamath, James H. Brauker, Paul V. Goode, Jr., Victoria E. Carr-Brendel
Принадлежит: Dexcom Inc

Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.

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Номер записи: 62
19-09-2013 дата публикации

SYSTEMS AND METHODS FOR PROCESSING ANALYTE SENSOR DATA

Номер: US20130245401A1
Автор: Bohm Sebastian Sebastian, Bohnett Lucas, Estes Michael J., Garcia Arturo, Kamath Apurv Ullas, Mahalingam Aarthi, Peyser Thomas A., Rack-Gomer Anna Leigh, Simpson Peter C., Vanslyke Stephen J.
Принадлежит: DexCom, Inc.

Systems and methods for applying time-dependent algorithmic compensation functions to data output from a continuous analyte sensor. Some embodiments determine a time since sensor implantation and/or whether a newly initialized sensor has been used previously. 1. A method of processing sensor data output by a continuous analyte sensor implanted within a body , comprising:measuring a change in sensitivity or baseline of the sensor over a time interval;determining a drift compensation function to be applied to a plurality of time-spaced data points output by the sensor; andapplying the drift compensation function continuously to the data points.2. The method of claim 1 , wherein measuring the change in sensitivity or baseline of the sensor comprises comparing a measured sensitivity or baseline of the sensor to a predetermined sensitivity or baseline of the sensor.3. The method of claim 2 , wherein determining a drift compensation function to be applied is based claim 2 , at least in part claim 2 , on the predetermined sensitivity or baseline.4. The method of claim 2 , wherein a value of the predetermined sensitivity or baseline is encoded on sensor electronics.5. The method of claim 1 , further comprising comparing the measured change in sensitivity or baseline of the sensor to a priori knowledge regarding the change in sensitivity or baseline of the sensor over the time interval.6. The method of claim 1 , further comprising claim 1 , based on the measured change in sensitivity or baseline of the sensor claim 1 , determining whether the sensor has been previously used.7. The method of claim 1 , wherein measuring the change in sensitivity or baseline of the sensor occurs only after the sensor has been implanted within the body for at least a minimum duration.8. The method of claim 1 , further comprising prompting a user for a reference analyte value when the measured change in sensitivity or baseline of the sensor exceeds a criterion.9. The method of claim 1 , further ...

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Номер записи: 63
19-09-2013 дата публикации

ANALYTE SENSOR WITH INCREASED REFERENCE CAPACITY

Номер: US20130245412A1
Автор: Bohm Sebastian, Rong Daiting, Wightlin Matthew D.
Принадлежит: DexCom, Inc.

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes an electrochemical sensor incorporating a silver/silver chloride reference electrode, wherein a capacity of the reference electrode is controlled. 1. An implantable electrochemical sensor for measuring an analyte concentration in a host , comprising:a working electrode configured to measure a concentration of an analyte; anda silver/silver chloride reference electrode, wherein at least a portion of the silver/silver chloride reference electrode is covered with an enzyme layer, wherein the enzyme layer is configured, in vivo, to generate hydrogen peroxide upon exposure to a substrate, whereby the hydrogen peroxide regenerates silver chloride of the reference electrode such that a reference capacity of the reference electrode is increased.2. The implantable electrochemical sensor of claim 1 , wherein the enzyme is an oxidase enzyme.3. The implantable electrochemical sensor of claim 2 , wherein the substrate is selected from the group consisting of glucose claim 2 , urate claim 2 , ascorbate claim 2 , citrate claim 2 , L-lactate claim 2 , succinate claim 2 , D-glucose claim 2 , and ethanol.4. The implantable electrochemical sensor of claim 1 , wherein the analyte is glucose.5. The implantable electrochemical sensor of claim 1 , wherein the reference electrode comprises a chloridized elongated silver body.6. The implantable electrochemical sensor of claim 1 , further comprising a diffusion barrier configured to substantially block diffusion of hydrogen peroxide between the silver/silver chloride reference electrode and the working electrode.7. The implantable electrochemical sensor of claim 1 , wherein the enzyme layer has a thickness from about 0.01 microns to about 12 microns thick.8. The implantable electrochemical sensor of claim 1 , wherein a percentage of a surface area of the reference ...

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Номер записи: 64
19-09-2013 дата публикации

SYSTEMS AND METHODS FOR PROCESSING ANALYTE SENSOR DATA

Номер: US20130245981A1
Автор: Bohm Sebastian, Bohnett Lucas, Estes Michael J., Garcia Arturo, Kamath Apurv Ullas, Mahalingam Aarthi, Peyser Thomas A., Rack-Gomer Anna Leigh, Simpson Peter C., Vanslyke Stephen J.
Принадлежит: DexCom, Inc.

Systems and methods for applying time-dependent algorithmic compensation functions to data output from a continuous analyte sensor. Some embodiments determine a time since sensor implantation and/or whether a newly initialized sensor has been used previously. 1. A method for processing sensor data of a continuous analyte sensor implanted within a body , comprising:initializing the sensor;applying a first set of time-dependent algorithmic functions to data associated with the sensor during a first interval based on a first elapsed time since the sensor was implanted; andapplying a second set of time-dependent algorithmic functions to the data associated with the sensor during a second interval after the first interval based on a second elapsed time since the sensor was implanted.2. The method of claim 1 , wherein initializing the sensor comprises engaging electronics associated with the sensor with a housing.3. The method of claim 2 , wherein engagement of the electronics with the receiving unit is detected and initialization commences automatically upon detection of the engagement.4. The method of claim 1 , further comprising determining whether the sensor has been previously used.5. The method of claim 4 , wherein determining whether the sensor has been previously used comprises comparing a conversion function of the sensor with a conversion function of a previously removed sensor.6. The method of claim 4 , wherein determining whether the sensor has been previously used comprises reading a raw signal of the sensor.7. The method of claim 4 , wherein determining whether the sensor has been previously used comprises comparing a sensitivity and/or baseline of the sensor with a sensitivity and/or baseline of a previously removed sensor.8. The method of claim 4 , wherein determining whether the sensor has been previously used comprises comparing a trend in a signal from the sensor with a trend in a signal from a previously removed sensor.9. The method of claim 4 , ...

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Номер записи: 65
26-09-2013 дата публикации

SYSTEMS AND METHODS FOR PROCESSING SENSOR DATA

Номер: US20130253418A1
Автор: Dobbles J. Michael, Kamath Apurv Ullas, LI Ying, Mahalingam Aarthi, Mensinger Michael Robert
Принадлежит: DexCom, Inc.

Systems and methods for processing sensor data are provided. In some embodiments, systems and methods are provided for calibration of a continuous analyte sensor. In some embodiments, systems and methods are provided for classification of a level of noise on a sensor signal. In some embodiments, systems and methods are provided for determining a rate of change for analyte concentration based on a continuous sensor signal. In some embodiments, systems and methods for alerting or alarming a patient based on prediction of glucose concentration are provided. 1. A method for processing continuous analyte sensor data , comprising:receiving sensor data from a continuous analyte sensor, the sensor data comprising one or more sensor data points;calibrating the sensor data using calibration information;calculating an accuracy of the sensor data; andproviding insulin delivery instructions and/or insulin therapy instructions based on a comparison of the calculated accuracy with one or more thresholds.2. The method of claim 1 , wherein the one or more thresholds delineate at least two predetermined ranges of accuracy.3. The method of claim 1 , wherein the one or more thresholds delineate at least three predetermined ranges of accuracy.4. The method of claim 1 , wherein the calculating the accuracy comprises evaluating the calibration information.5. The method of claim 1 , wherein the calculating the accuracy is based on a signal indicative of drift.6. The method of claim 1 , wherein the calculating the accuracy comprises calculating a difference between the sensor data and its corresponding reference data.7. The method of claim 1 , wherein the calculating the accuracy is performed on calibrated sensor data in units of blood glucose concentration.8. The method of claim 1 , wherein the providing insulin delivery instructions and/or insulin therapy instructions comprises controlling an insulin pump.9. The method of claim 1 , wherein the providing insulin delivery instructions and/ ...

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Номер записи: 66
03-10-2013 дата публикации

TRANSCUTANEOUS ANALYTE SENSOR

Номер: US20130255570A1
Автор: Brauker James, Brister Mark, Ha Victor, NOLTING John, Petisce James R., SAINT Sean, Simpson Peter C., Woo Kum Ming
Принадлежит: DexCom, Inc.

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 1. A system for manufacturing a continuous glucose sensor , comprising:a plurality of stations; andan automated or semi-automated mechanism configured to continuously move an elongated conductive body through the plurality of stations;wherein the elongated conductive body comprises an electroactive surface, and wherein the plurality of stations are configured to serially deposit a plurality of membrane layers to form a membrane configured to control a flux of glucose to the electroactive surface.2. The system of claim 1 , wherein the plurality of stations comprise a station for cutting the elongated conductive body to form a plurality of continuous glucose sensors.3. The system of claim 1 , wherein the plurality of stations comprises a station for curing the membrane.4. The system of claim 1 , wherein the plurality of stations comprises a station for depositing a coating material to form a layer comprising an enzyme.5. The system of claim 1 , wherein the plurality of stations comprises a station for depositing a coating material to form a layer configured to block or reduce passage of one or more interferents.6. The system of claim 1 , wherein the plurality of stations comprises a station for depositing a coating material to form a layer configured to control a flux of glucose.7. The system for claim 1 , wherein the elongated conductive body comprises at least one material selected from the group consisting of: platinum claim 1 , platinum-iridium claim 1 , palladium claim 1 , graphite claim 1 , gold claim 1 , carbon claim 1 , conductive polymer claim 1 , and alloys or combinations thereof.8. The system of claim 1 , wherein the elongated conductive body comprises a plated wire.9. The system of claim 1 , wherein the automated or semi-automated ...

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Номер записи: 67
10-10-2013 дата публикации

TRANSCUTANEOUS ANALYTE SENSORS, APPLICATORS THEREFOR, AND ASSOCIATED METHODS

Номер: US20130267811A1
Автор: Bohm Sebastian, DeRenzy David, Halac Jason, Kline Daniel S., Lieu Phong, Livingston Adam J., Masterson Steve, Neale Paul V., Pryor Jack, Simpson Peter C., Ubach Antonio Joao
Принадлежит: DexCom, Inc.

The present embodiments relate generally to systems and methods for measuring an analyte in a host. More particularly, the present embodiments provide sensor applicators and methods of use with pushbutton activation that implant the sensor, withdraw the insertion needle, engage the transmitter with the housing, and disengage the applicator from the housing, all in one smooth motion. Some embodiments contemplate engagement of the transmitter with the housing after release of the applicator. 1. A device for applying an on-skin sensor assembly to skin of a host , the device comprising:a base configured to secure a housing, wherein the housing is configured to receive an electronics unit, wherein the electronics unit is configured to generate analyte information based on a signal from a sensor;a sensor insertion mechanism configured to insert the sensor into the host; anda trigger configured, in response to being activated, to cause the sensor insertion mechanism to insert the sensor into the host, to secure the electronics unit to the housing such that the sensor electrically contacts the electronics unit, and to cause the housing to detach from the base.2. The device of claim 1 , wherein the electronics unit is configured claim 1 , in response to the trigger being activated and/or the electrical connection of the sensor to the electronics unit claim 1 , to generate analyte information.3. The device of claim 1 , wherein the housing is configured such that the electronics unit cannot be removed from the housing while the housing is adhered to the skin of the host.4. The device of claim 1 , wherein the base is configured to draw the electronics unit into the housing.5. The device of claim 1 , further comprising a standoff configured to limit an extent to which the electronics unit is inserted into the housing prior to sensor insertion.6. The device of claim 5 , wherein the trigger is further configured claim 5 , in response to being activated claim 5 , to release the ...

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Номер записи: 68
10-10-2013 дата публикации

TRANSCUTANEOUS ANALYTE SENSORS, APPLICATORS THEREFOR, AND ASSOCIATED METHODS

Номер: US20130267812A1
Автор: Bohm Sebastian, DeRenzy David, Halac Jason, Kline Daniel S., Lieu Phong, Livingston Adam J., Masterson Steve, Neale Paul V., Pryor Jack, Simpson Peter C., Ubach Antonio Joao
Принадлежит: DexCom, Inc.

The present embodiments relate generally to systems and methods for measuring an analyte in a host. More particularly, the present embodiments provide sensor applicators and methods of use with pushbutton activation that implant the sensor, withdraw the insertion needle, engage the transmitter with the housing, and disengage the applicator from the housing, all in one smooth motion. Some embodiments contemplate engagement of the transmitter with the housing after release of the applicator. 1. A device for applying an on-skin sensor assembly to skin of a host , the device comprising:a base configured to secure a housing; andan electronics unit including at least one electrical contact, wherein the housing is configured to receive the electronics unit, wherein the electronics unit is configured to generate analyte information based on a signal from a sensor;wherein the base includes a mechanism to apply a seating force to the electronics unit in a direction of insertion of the electronics unit into the housing upon partial seating of the electronics unit within the housing.2. The device of claim 1 , wherein the seating force is about 0.25-3 lbs.3. The device of claim 1 , wherein upon activation of the device claim 1 , a sealing force is applied to the sensor that is about 2-3 times the magnitude of the seating force.4. The device of claim 1 , wherein the mechanism includes a pair of spring arms claim 1 , wherein the spring arms are pre-loaded with stored energy claim 1 , and wherein the device is configured such that partially seating the electronics unit within the housing releases the stored energy.5. The device of claim 1 , wherein the mechanism includes a pair of spring arms claim 1 , and wherein the spring arms are pre-loaded with stored energy claim 1 , and wherein the device is configured such that activating the device releases the stored energy.6. The device of claim 1 , wherein the device is configured such that upon activation of the device the force moves ...

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Номер записи: 69
10-10-2013 дата публикации

TRANSCUTANEOUS ANALYTE SENSORS, APPLICATORS THEREFOR, AND ASSOCIATED METHODS

Номер: US20130267813A1
Автор: Bohm Sebastian, DeRenzy David, Halac Jason, Kline Daniel S., Lieu Phong, Livingston Adam J., Masterson Steve, Neale Paul V., Pryor Jack, Simpson Peter C., Ubach Antonio Joao
Принадлежит: DexCom, Inc.

The present embodiments relate generally to systems and methods for measuring an analyte in a host. More particularly, the present embodiments provide sensor applicators and methods of use with pushbutton activation that implant the sensor, withdraw the insertion needle, engage the transmitter with the housing, and disengage the applicator from the housing, all in one smooth motion. Some embodiments contemplate engagement of the transmitter with the housing after release of the applicator. 1. A method of applying an on-skin sensor assembly to a host , wherein the on-skin sensor assembly comprises a housing secured to the applicator , wherein the housing is configured to receive an electronics unit , comprising:attaching an applicator to a skin of a host, the applicator comprising a sensor insertion mechanism, a trigger, and a base;inserting the electronics unit into the housing, wherein the electronics unit is configured to generate analyte information based on a signal from a sensor;activating the trigger, thereby causing the sensor insertion mechanism to insert a sensor into the host, to secure the electronics unit to the housing such that the sensor electrically contacts the electronics unit, and to cause the housing to detach from the base; andremoving the applicator from the skin of the host, whereby an on-skin sensor assembly comprising the housing, the electronics unit, and the inserted sensor remains on the skin of the host.2. The method of claim 1 , wherein attaching the applicator to the skin of the host occurs before the electronics unit is inserted into the housing.3. The method of claim 1 , wherein attaching the applicator to the skin of the host occurs after the electronics unit is inserted into the housing.4. The method of claim 1 , further comprising claim 1 , before applying the applicator claim 1 , removing a door from the applicator covering a port configured for receiving the electronics unit when the electronics unit is inserted into the housing ...

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Номер записи: 70
21-11-2013 дата публикации

DEVICE AND METHOD FOR DETERMINING ANALYTE LEVELS

Номер: US20130310666A1
Автор: Gilligan Barbara J., Rhodes Rathbun K, Shults Mark C., Tapsak Mark A., Updike Stuart J.
Принадлежит: DexCom, Inc.

Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time. 1. An implantable optical-based continuous glucose sensing device , the device comprising:a membrane comprising partial metallization of a distal side of the membrane, wherein the membrane is configured to interface with tissue;a radiation source;an optical sensor configured to measure a signal indicative of glucose concentration;a housing configured to receive the radiation source and the optical sensor.2. The device of claim 1 , wherein the metallization comprises platinum.3. The device of claim 1 , wherein the metallization comprises vacuum deposited metal.4. The device of claim 1 , further comprising fluorescence sensing molecules configured to detect a presence of glucose.5. The device of claim 1 , wherein the membrane is configured to protect the sensor from in vivo environmental conditions. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 13/411,414, filed Mar. 2, 2012, which is a continuation of U.S. application Ser. No. 12/696,003, filed Jan. 28, 2010, now U.S. Pat. No. 8,155,723, which is a continuation of U.S. application Ser. No. 11/546,157, filed Oct. 10, 2006, now abandoned, which is a continuation of U.S. application Ser. No. 11/039,269, filed Jan. 19, 2005, now U.S. Pat. No. 7,136,689, which is a continuation of U.S. application Ser. No. 09/916,858, filed Jul. 27, 2001, now U.S. Pat. No. 6,862,465, which is a continuation-in-part of U.S. application Ser. No. 09/447, ...

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Номер записи: 71
21-11-2013 дата публикации

SILICONE BASED MEMBRANES FOR USE IN IMPLANTABLE GLUCOSE SENSORS

Номер: US20130310670A1
Автор: Boock Robert J., Rixman Monica A.
Принадлежит: DexCom, Inc.

Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility. 1. An implantable continuous analyte sensor , comprising:a working electrode; anda membrane system disposed over at least a portion of the working electrode, the membrane system comprising a first domain and a second domain, the first domain and the second domain each comprising a blend comprising a silicone-containing polymer and a hydrophilic polymer, the first domain having a blend ratio of silicone-containing polymer to hydrophilic polymer that is different than a blend ratio of silicone-containing polymer to hydrophilic polymer of the second domain.2. The implantable continuous analyte sensor of claim 1 , wherein the first domain is less permeable to an interfering species than to an analyte.3. The implantable continuous analyte sensor of claim 1 , wherein the first domain is configured to provide a greater reduction of transport of an interfering species therethrough than the second domain.4. An implantable continuous analyte sensor claim 1 , comprising:a working electrode; and a first domain configured to have a greater selectivity for reducing permeability therethrough of a first interfering species than a second interfering species;', 'a second domain configured to have a greater selectivity for reducing permeability therethrough of a second interfering species than a first interfering species; and', 'a third domain comprising an enzyme configured to react with an analyte; and', 'wherein the first and second interfering species are molecules that would be electro-reduced or electro-oxidized by the working electrode if they reached an electroactive surface the ...

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Номер записи: 72
05-12-2013 дата публикации

REPORTING MODULES

Номер: US20130321425A1
Автор: Greene Adam R., Root Daniel N., Schumacher Justin E.
Принадлежит: DexCom, Inc.

Methods and apparatus, including computer program products, are provided for processing analyte data. In some exemplary implementations, there is provided a method. The method may include generating, by at least one processor, a view comprising an abstraction distilled from the sensor data over a time period. The view may further comprise a graphical representation comprising a plurality of different graphically distinct elements representative of whether the abstraction over the time period is at least one of at, above, or within a predetermined glucose concentration level for a host; a call out comprising value help for the graphical representation, and a textual legend comprising a description of the graphical representation and the abstraction. The method may further include providing the view as a module. Related systems, methods, and articles of manufacture are also disclosed. 1. A method for generating a user interface associated with sensor data representative of a glucose concentration level in a host , comprising: a graphical representation comprising a plurality of different graphically distinct elements representative of whether the abstraction over the time period is at least one of at, above, or within a predetermined glucose concentration level for the host,', 'a call out comprising value help for the graphical representation, and', 'a textual legend comprising a description of the graphical representation and the abstraction; and, 'generating, by at least one processor, a view comprising an abstraction distilled from the sensor data over a time period, wherein the view further comprisesproviding, by the at least one processor, the view as a module.2. The method of claim 1 , wherein the time frame is selected from the group consisting of 8 hours claim 1 , 1 day claim 1 , 2 days claim 1 , 7 days claim 1 , and 30 days.3. The method of claim 1 , wherein the graphically distinct elements use at least one of different shading or position to represent ...

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Номер записи: 73
05-12-2013 дата публикации

INTEGRATED MEDICAMENT DELIVERY DEVICE FOR USE WITH CONTINUOUS ANALYTE SENSOR

Номер: US20130321426A1
Автор: Kamath Apurv Ullas, Leach Jacob S., Quintana Nelson, Yang Richard C.
Принадлежит: DexCom, Inc.

An integrated system for the monitoring and treating diabetes is provided, including an integrated receiver/hand-held medicament injection pen, including electronics, for use with a continuous glucose sensor. In some embodiments, the receiver is configured to receive continuous glucose sensor data, to calculate a medicament therapy (e.g., via the integrated system electronics) and to automatically set a bolus dose of the integrated hand-held medicament injection pen, whereby the user can manually inject the bolus dose of medicament into the host. In some embodiments, the integrated receiver and hand-held medicament injection pen are integrally formed, while in other embodiments they are detachably connected and communicated via mutually engaging electrical contacts and/or via wireless communication. 1. A graphical user interface on a display device , comprising:a graph having an x-axis representative of time and a y-axis representative of glucose concentration; andone or more representations of sensor data plotted on the graph according to a value of the sensor data as compared to a predetermined target glucose concentration.2. The graphical user interface of claim 1 , wherein the representation of the sensor data is illustrated as a series of bars claim 1 , the series of bars including both bars representative of glucose concentration below the predetermined target and bars representative of glucose concentration above the predetermined target.3. The graphical user interface of claim 1 , further comprising a line representative of the predetermined target glucose concentration claim 1 , wherein representations of sensor data below the predetermined target extend below a target line claim 1 , and representations of sensor data above the predetermined target extend above the target line.4. The graphical user interface of claim 1 , wherein the sensor data is generated by a continuous glucose sensor claim 1 , and wherein the graphical user interface displays the graph ...

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Номер записи: 74
05-12-2013 дата публикации

INTEGRATED MEDICAMENT DELIVERY DEVICE FOR USE WITH CONTINUOUS ANALYTE SENSOR

Номер: US20130324824A1
Автор: Kamath Apurv Ullas, Leach Jacob S., Quintana Nelson, Yang Richard C.
Принадлежит: DexCom, Inc.

An integrated system for the monitoring and treating diabetes is provided, including an integrated receiver/hand-held medicament injection pen, including electronics, for use with a continuous glucose sensor. In some embodiments, the receiver is configured to receive continuous glucose sensor data, to calculate a medicament therapy (e.g., via the integrated system electronics) and to automatically set a bolus dose of the integrated hand-held medicament injection pen, whereby the user can manually inject the bolus dose of medicament into the host. In some embodiments, the integrated receiver and hand-held medicament injection pen are integrally formed, while in other embodiments they are detachably connected and communicated via mutually engaging electrical contacts and/or via wireless communication. 1. A method for processing continuous glucose sensor data and displaying a graphical representation of the processed sensor data , the method comprising:processing continuous glucose sensor data generated using a continuous glucose sensor, the sensor data indicative of a host's glucose concentration;displaying a graphical representation of the processed sensor data on a display device, the displaying including graphing or charting glucose data summaries based on mealtimes of the host.2. The method of claim 1 , wherein the processed sensor data includes averaged glucose values over a time period.3. The method of claim 2 , wherein the time period is one of 1 day claim 2 , 5 days claim 2 , 7 days or 1 month.4. The method of claim 1 , wherein the glucose data summaries are modal day graphs.5. The method of claim 1 , wherein the glucose data summaries include bar charts.6. The method of claim 1 , wherein the glucose data summaries include glucose trend data.7. A system for processing continuous glucose sensor data and displaying a graphical representation of the processed sensor data claim 1 , the system comprising:one or more processors;computer memory; andcomputer-readable ...

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Номер записи: 75
05-12-2013 дата публикации

DYNAMIC REPORT BUILDING

Номер: US20130325504A1
Автор: Greene Adam R., Root Daniel N., Schumacher Justin E.
Принадлежит: DexCom, Inc.

Methods and apparatus, including computer program products, are provided for processing analyte data. In some exemplary implementations, there is provided a method. The method may include selecting at least one module from among a plurality of modules, the selection performed based on metadata including one or more of the following rules: whether the at least one module can be used with a type of device, whether the at least one module can be used with a glycemic state of a host, and whether the at least one module can be used with an expected volume of data generated by the type of device; and generating a report including the selected at least one module configured to present information representative of the glucose concentration level measured in the host. Related systems, methods, and articles of manufacture are also disclosed. 1. A method for generating reports for sensor data representative of a glucose concentration level in a host , comprising:receiving a request to generate a report;selecting, in response to the request, at least one module from among a plurality of modules, the selection performed based on metadata including information representative of at least one of the host and a type of device being used to measure the glucose concentration level;generating the report including the selected at least one module configured to present within a single view information representative of the glucose concentration level measured in the host; andproviding the generated report to a user interface for presentation, wherein the receiving, the selecting, the generated, and the providing are implemented by at least one processor.2. The method of claim 1 , wherein the information representative of the host further comprises at least one of a user preference for the at least one module and host identification information claim 1 , and wherein the metadata further comprises one or more rules.3. The method of claim 2 , wherein the user preference comprises a ...

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Номер записи: 76
02-01-2014 дата публикации

ELECTRODE SYSTEMS FOR ELECTROCHEMICAL SENSORS

Номер: US20140001042A1
Автор: Brauker James H., Carr-Brendel Victoria E., Petisce James R., Simpson Peter C.
Принадлежит: DexCom, Inc.

The present invention relates generally to systems and methods for improved electrochemical measurement of analytes. The preferred embodiments employ electrode systems including an analyte-measuring electrode for measuring the analyte or the product of an enzyme reaction with the analyte and an auxiliary electrode configured to generate oxygen and/or reduce electrochemical interferants. Oxygen generation by the auxiliary electrode advantageously improves oxygen availability to the enzyme and/or counter electrode; thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. Interferant modification by the auxiliary electrode advantageously renders them substantially non-reactive at the analyte-measuring electrode, thereby reducing or eliminating inaccuracies in the analyte signal due to electrochemical interferants. 1. An electrochemical sensor for determining a presence or a concentration of an analyte in a fluid , the sensor comprising:a membrane system comprising an enzyme, wherein the enzyme reacts with the analyte;an electroactive surface comprising a working electrode, the working electrode comprising a conductive material and configured to measure a product of the reaction of the enzyme with the analyte; andan auxiliary electrode comprising a conductive material and configured to modify an electrochemical interferent such that the electrochemical interferent is rendered substantially electrochemically non-reactive at the working electrode.2. The electrochemical sensor of claim 1 , wherein the auxiliary electrode comprises a conductive material selected from the group consisting of a conductive metal claim 1 , a conductive polymer claim 1 , and a blend of a conductive metal and a conductive polymer.3. The electrochemical sensor of claim 1 , wherein the auxiliary electrode comprises a form selected from the group consisting of a mesh claim 1 , a grid claim 1 , and a plurality of spaced wires.4. The ...

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Номер записи: 77
02-01-2014 дата публикации

USE OF SENSOR REDUNDANCY TO DETECT SENSOR FAILURES

Номер: US20140005505A1
Автор: Bhavaraju Naresh C., Bowman Leif N., Kamath Apurv Ullas, Mahalingam Aarthi, Peyser Thomas A., Pryor Jack, Simpson Peter C.
Принадлежит: DexCom, Inc.

Devices, systems, and methods for providing more accurate and reliable sensor data and for detecting sensor failures. Two or more electrodes can be used to generate data, and the data can be subsequently compared by a processing module. Alternatively, one sensor can be used, and the data processed by two parallel algorithms to provide redundancy. Sensor performance, including sensor failures, can be identified. The user or system can then respond appropriately to the information related to sensor performance or failure. 1. A method for detecting a sensor failure in a continuous analyte monitoring system implanted in a host , the method comprising:receiving first sensor data from a first electrode implanted in the host, wherein the first sensor data are indicative of a property corresponding to the first electrode;receiving second sensor data from a second electrode implanted in the host, wherein the second sensor data are indicative of the property corresponding to the second electrode, the first electrode and the second electrode having substantially same characteristics;comparing, using a processor module, the property corresponding to the first electrode with the property corresponding to the second electrode; andidentifying a failure in at least one of the first electrode or the second electrode when a property magnitude of the first electrode is different from a property magnitude of the second electrode by a predetermined value.2. The method of claim 1 , wherein the property is sensor sensitivity to an analyte.3. The method of claim 1 , wherein the property is baseline.4. The method of claim 1 , wherein the first electrode is located substantially adjacent to the second electrode.5. The method of claim 1 , wherein the first electrode and the second electrode are separated by a distance of less than about 1 mm at a closest proximity.6. The method of claim 1 , wherein the first electrode and the second electrode are separated by a distance of less than about 0.5 ...

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Номер записи: 78
02-01-2014 дата публикации

Devices, systems, and methods to compensate for effects of temperature on implantable sensors

Номер: US20140005508A1
Автор: Jack Pryor, Jennifer Blackwell, Matthew D. Wightlin, Michael J. Estes, Peter C. Simpson, Robert J. Boock, Sebastian Böhm
Принадлежит: Dexcom Inc

Systems and methods for compensating for effects of temperature on implantable sensors are provided. In some embodiments, systems and methods are provided for measuring a temperature to determine a change in temperature in a sensor environment. In certain embodiments, a temperature compensation factor is determined based on a change in temperature of the sensor environment. The temperature compensation factor can be used in processing raw data of an analyte signal to report a more accurate analyte concentration.

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Номер записи: 79
02-01-2014 дата публикации

IMPLANTABLE SENSOR DEVICES, SYSTEMS, AND METHODS

Номер: US20140005509A1
Автор: Bhavaraju Naresh C., Bohm Sebastian, Boock Robert J., Rong Daiting, Simpson Peter C.
Принадлежит: DexCom, Inc.

Disclosed herein are devices, systems, and methods for a continuous analyte sensor, such as a continuous glucose sensor. In certain embodiments disclosed herein, various in vivo properties of the sensor's surroundings can be measured. In some embodiments, the measured properties can be used to identify a physiological response or condition in the body. This information can then be used by a patient, doctor, or system to respond appropriately to the identified condition. 1. A method for processing data from a continuous glucose sensor , the method comprising:receiving sensor data generated by a continuous glucose sensor, wherein the sensor data is indicative of a concentration of glucose in a host;identifying, using a processor module, a post-implantation loss of sensitivity of the continuous glucose sensor; andprocessing the sensor data, using the processor module, responsive to the identification of the loss of sensitivity.2. The method of claim 1 , wherein the sensor data comprises data indicative of a signal response to at least one event selected from the group consisting of a signal response to cessation of blood flow to a site surrounding sensor implantation claim 1 , a signal response to reduction of blood flow to a site surrounding sensor implantation claim 1 , and a signal response to a vasospastic event.3. The method of claim 1 , wherein identifying the post-implantation loss of sensitivity comprises determining a severity of the loss of sensitivity.4. The method of claim 3 , wherein processing the sensor data is performed based on the severity of the loss of sensitivity.5. The method of claim 1 , wherein identifying the post-implantation loss of sensitivity comprises:deactivating the continuous glucose sensor for a time period, whereby a product from a catalyzed reaction of glucose and oxygen accumulates over the time period;activating the continuous glucose sensor and measuring a signal value of the continuous glucose sensor immediately after the time ...

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Номер записи: 80
09-01-2014 дата публикации

SYSTEMS AND METHODS FOR LEVERAGING SMARTPHONE FEATURES IN CONTINUOUS GLUCOSE MONITORING

Номер: US20140012117A1
Автор: Bhavaraju Naresh C., Bowman Leif N., Carlton Alexandra Lynn, Cohen Eric, DeRenzy David, Estes Michael J., Garcia Arturo, Gauba Indrawati, Hall Ashley, Hall Thomas, Hampapuram Hari, Kazalbash Murrad, Mahalingam Aarthi, Mensinger Michael Robert, Pryor Jack, Rack-Gomer Anna Leigh, Reihman Eli, San Vicente Kenneth, Simpson Peter C., Steele Alexander, Valdes Jorge
Принадлежит: DexCom, Inc.

The present embodiments harness a wide variety of capabilities of modern smartphones, and combine these capabilities with information from a continuous glucose monitor to provide diabetics and related people with more information than the continuous glucose monitor can provide by itself. The increased information provides the diabetic with an increased likelihood of good diabetes management for better health. 1. A machine-executed method of continuous glucose monitoring for a host to facilitate management of the host's blood glucose level , the method comprising:displaying a blood glucose trend graph on a display of an electronic device;receiving an input of at least one location on the trend graph;processing the input by determining a value of the host's glucose concentration at the at least one location; andproducing an output of the value on the display.2. The method of claim 1 , wherein the input is locations of two points on the trend graph where the electronic device has sensed a user has placed his or her fingers.3. The method of claim 2 , wherein the processing comprises determining values of glucose concentration at the two points.4. The method of claim 3 , wherein the output is a value of a difference between glucose concentration values at the two points.5. The method of claim 3 , wherein the output is a value of a rate of change of glucose concentration between the two points.6. The method of claim 1 , wherein the glucose concentration trend graph comprises a macro trend graph that displays the user's glucose concentration data for a given length of time claim 1 , and a micro trend graph that displays the user's glucose concentration data for a segment of the time shown on the macro trend graph.7. The method of claim 6 , wherein a movable bar on the macro trend graph highlights the segment of the time on the macro trend graph that is displayed on the micro trend graph.8. The method of claim 7 , wherein the bar is movable to select any desired window of ...

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Номер записи: 81
09-01-2014 дата публикации

SYSTEMS AND METHODS FOR LEVERAGING SMARTPHONE FEATURES IN CONTINUOUS GLUCOSE MONITORING

Номер: US20140012118A1
Автор: Bhavaraju Naresh C., Bowman Leif N., Carlton Alexandra Lynn, Cohen Eric, DeRenzy David, Estes Michael J., Garcia Arturo, Gauba Indrawati, Hall Ashley, Hall Thomas, Hampapuram Hari, Kazalbash Murrad, Mahalingam Aarthi, Mensinger Michael Robert, Pryor Jack, Rack-Gomer Anna Leigh, Reihman Eli, San Vicente Kenneth, Simpson Peter C., Steele Alexander, Valdes Jorge
Принадлежит: DexCom, Inc.

The present embodiments harness a wide variety of capabilities of modern smartphones, and combine these capabilities with information from a continuous glucose monitor to provide diabetics and related people with more information than the continuous glucose monitor can provide by itself. The increased information provides the diabetic with an increased likelihood of good diabetes management for better health. 1. A machine-executed method of continuous analyte monitoring for a host to facilitate management of the host's analyte concentration level , the method comprising:transmitting, using a computing device, an identification of a version of an operating system of the computing device and/or a continuous analyte monitoring (CAM) software application installed on the computing device to a remote server, the CAM software application comprising instructions, when executed by a processor of the computing device, that cause the computing device to process and display analyte concentration information;receiving a response from the remote server responsive indicative of a compatibility check of the version of the operating system with the version of the CAM software application; andproducing an output to responsive to the response.2. The method of claim 1 , wherein the output comprises continuing operating the CAM module.3. The method of claim 1 , wherein the output comprises disabling one or more features of the CAM module.4. The method of claim 1 , wherein the output comprises preventing operation of the CAM module.5. The method of claim 1 , wherein the output comprises displaying a message to a user of the electronic device indicative of the compatibility check.6. The method of claim 5 , wherein the message instructs the user to change at least one of the operating system and the CAM module to a different version.7. The method of claim 1 , wherein the CAM module is a software application stored on the electronic device.8. The method of claim 1 , wherein the ...

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Номер записи: 82
09-01-2014 дата публикации

SYSTEMS AND METHODS FOR LEVERAGING SMARTPHONE FEATURES IN CONTINUOUS GLUCOSE MONITORING

Номер: US20140012510A1
Автор: Bhavaraju Naresh C., Bowman Leif N., Carlton Alexandra Lynn, Cohen Eric, DeRenzy David, Estes Michael J., Garcia Arturo, Gauba Indrawati, Hall Ashley, Hall Thomas, Hampapuram Hari, Kazalbash Murrad, Mahalingam Aarthi, Mensinger Michael Robert, Pryor Jack, Rack-Gomer Anna Leigh, Reihman Eli, San Vicente Kenneth, Simpson Peter C., Steele Alexander, Valdes Jorge
Принадлежит: DexCom, Inc

The present embodiments harness a wide variety of capabilities of modern smartphones, and combine these capabilities with information from a continuous glucose monitor to provide diabetics and related people with more information than the continuous glucose monitor can provide by itself. The increased information provides the diabetic with an increased likelihood of good diabetes management for better health. 1. A machine-executed method of continuous analyte monitoring for a host to facilitate management of the host's blood glucose level , the method comprising:receiving a first input from a timekeeping/scheduling module executed by an electronic device, the first input including information about an upcoming event;receiving a second input from a continuous analyte monitoring (CAM) device including analyte concentration data of the host;processing the first and second inputs by analyzing an event or an operational mode associated with either of the timekeeping/scheduling module or the CAM device; andproducing an output by synchronizing the event or the operational mode of at least one of the timekeeping/scheduling module and the CAM device with the other of the timekeeping/scheduling module and the CAM device.2. The method of claim 1 , wherein the output is to the timekeeping/scheduling module to schedule an event.3. The method of claim 1 , wherein the event is to eat claim 1 , to obtain a reference glucose value claim 1 , or to inject insulin.4. The method of claim 1 , wherein the wherein the output is sent to a user claim 1 , a caretaker claim 1 , a parent claim 1 , a guardian claim 1 , or a healthcare professional.5. The method of claim 1 , wherein the output is a recommendation provided via screen prompt claim 1 , text message claim 1 , e-mail message claim 1 , or a post to a social network.6. The method of claim 1 , wherein the output is a change in the operating mode of the electronic device.7. The method of claim 6 , wherein the operating mode is a vibrate ...

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Номер записи: 83
06-02-2014 дата публикации

INTEGRATED INSULIN DELIVERY SYSTEM WITH CONTINUOUS GLUCOSE SENSOR

Номер: US20140039383A1
Автор: Brauker James H., Dobbles Mike, Kamath Apurv Ullas, Mahalingam Aarthi
Принадлежит: DexCom, Inc.

Systems and methods for integrating a continuous glucose sensor , including a receiver , a medicament delivery device , a controller module, and optionally a single point glucose monitor are provided. Integration may be manual, semi-automated and/or fully automated. 1. An integrated system for monitoring a glucose concentration in a host and for delivering insulin to a host , the system comprising:a continuous glucose sensor, wherein the continuous glucose sensor is configured to substantially continuously measure a glucose concentration in a host, and to provide sensor data associated with the glucose concentration in the host;an electronics module comprising an on/off controller module configured to iteratively determine an insulin therapy instruction in response to an evaluation of a relationship of internally derived data and a glucose boundary, wherein the insulin therapy instruction comprises an instruction selected from the group consisting of on and off; andan insulin delivery device configured to deliver insulin to the host, wherein the insulin delivery device is at least one of physically connected to a receiver and operably connected to a receiver, wherein the insulin delivery device is configured to receive the insulin therapy instruction from the controller.2. The integrated system of claim 1 , wherein the insulin therapy instruction is determined solely on internally derived data and the glucose boundary.3. The integrated system of claim 1 , wherein the glucose boundary is programmable by at least one of the host claim 1 , a caretaker of the host claim 1 , the on/off controller module claim 1 , and a manufacturer of the integrated system.4. The integrated system of claim 1 , wherein the glucose boundary is a glucose concentration of from about 70 mg/dl to about 160 mg/dl.5. The integrated system of claim 1 , wherein an on insulin therapy instruction is determined when the glucose concentration exceeds the glucose boundary.6. The integrated system of ...

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Номер записи: 84
13-02-2014 дата публикации

ANALYTE SENSOR

Номер: US20140046148A1
Автор: Book Robert J., Estes Michael J., Kamath Apurv Ullas, Simpson Peter C., Wightlin Matthew D.
Принадлежит: DexCom, Inc.

Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system is provided having a first working electrode comprising a first sensor element and a second working electrode comprising a second sensor element , and a reference electrode for providing a reference value for measuring the working electrode potential of the sensor elements 1. A sensor system for continuous measurement of a glucose concentration in a host , the sensor system comprising:a first sensor configured to measure glucose concentrations over a first time period of in vivo implantation; anda second sensor configured to measure glucose concentrations over a second time period of in vivo implantation, wherein the first time period and the second time period are different.2. The sensor system of claim 1 , wherein the first time period corresponds to an initial period of in vivo implantation claim 1 , wherein the second time period corresponds to a second time period of in vivo implantation claim 1 , and wherein the second period begins after the initial period of in vivo implantation has begun.3. The sensor system of claim 2 , wherein the first time period and the second time period overlap partially claim ...

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Номер записи: 85
13-02-2014 дата публикации

Analyte sensor

Номер: US20140046149A1
Автор: Apurv Ullas Kamath, Matthew D. Wightlin, Michael J. Estes, Peter C. Simpson, Robert J. Boock
Принадлежит: Dexcom Inc

Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system 180 is provided having a first working electrode 150 comprising a first sensor element 102 and a second working electrode 160 comprising a second sensor element 104 , and a reference electrode 108 for providing a reference value for measuring the working electrode potential of the sensor elements 102, 104.

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Номер записи: 86
13-02-2014 дата публикации

POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS

Номер: US20140046158A1
Автор: Boock Robert J., Estes Michael J., Lawrence Kristina, Rixman Monica A., ZHANG Huashi
Принадлежит: DexCom, Inc.

Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species. 1. A system for continuous in vivo measurement of a glucose concentration , the system comprising:an implantable sensor configured to continuously measure a signal indicative of a glucose concentration in a host; and a polymer comprising a hydrophilic segment, and', 'a polyurethane comprising a plurality of repeating hard segments and repeating soft segments and a hydrophobic end group, wherein a soft segment of the plurality of repeating soft segments has a molecular weight from about 200 Daltons to about 50,000 Daltons, wherein a hard segment of the plurality of repeating hard segments has a molecular weight from about 160 Daltons to about 10,000 Daltons, wherein the blend of the polymer and the polyurethane comprises both hydrophilic and hydrophobic regions, whereby diffusion of glucose and oxygen through the second domain is controlled; and, 'a membrane located over the sensor, wherein the membrane comprises a first domain comprising an enzyme configured to react with glucose to produce a measured species configured to be oxidized at the sensor, wherein the membrane comprises a second domain comprising a blend comprisingsensor electronics operably connected to the sensor, wherein the sensor electronics are configured to measure a current flow produced by the sensor to generate sensor data indicative of glucose concentration.2. The system of claim 1 , wherein the hydrophilic regions collectively comprise 5% to 50% by weight of the second domain.3. The system of claim 1 , wherein the silicone end group is covalently bonded to ...

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Номер записи: 87
20-02-2014 дата публикации

INTEGRATED INSULIN DELIVERY SYSTEM WITH CONTINUOUS GLUCOSE SENSOR

Номер: US20140052091A1
Автор: Brauker James H., Dobbles John Michael, Kamath Apurv Ullas, Mahalingam Aarthi
Принадлежит: DexCom, Inc.

Systems and methods for integrating a continuous glucose sensor , including a receiver , a medicament delivery device , a controller module, and optionally a single point glucose monitor are provided. Integration may be manual, semi-automated and/or fully automated. 1. An integrated system for monitoring a glucose concentration in a host and for delivering insulin to the host , the system comprising:a continuous glucose sensor, wherein the continuous glucose sensor is configured to substantially continuously measure a glucose concentration in a host, and to provide sensor data associated with the glucose concentration of the host;an electronics module comprising a basal controller module configured to iteratively determine an insulin therapy instruction in response to an evaluation of a relationship of internally derived data and a basal profile, wherein the basal profile comprises at least one time block associated with a maximum insulin delivery rate; andan insulin delivery device configured to deliver insulin to the host, wherein the insulin delivery device is at least one of physically connected to a receiver and/or operably connected to a receiver, wherein the insulin delivery device is configured to receive the insulin therapy instruction from the basal controller module, and wherein the insulin therapy instruction is constrained by a maximum insulin delivery rate associated with a current time block.2. The integrated system of claim 1 , wherein the insulin therapy instruction is determined solely on internally derived data and the basal profile.3. The integrated system of claim 1 , wherein the maximum insulin delivery rate is an insulin delivery rate of from about 0.01 U/hour to about 6.0 U/hour.4. The integrated system of claim 1 , wherein the insulin delivery device is configured to deliver insulin automatically in response to receiving the insulin therapy instruction.5. The integrated system of claim 1 , wherein the insulin therapy instruction instructs ...

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Номер записи: 88
20-02-2014 дата публикации

INTEGRATED INSULIN DELIVERY SYSTEM WITH CONTINUOUS GLUCOSE SENSOR

Номер: US20140052092A1
Автор: Brauker James H., Dobbles John Michael, Kamath Apurv Ullas, Mahalingam Aarthi
Принадлежит: DexCom, Inc.

Systems and methods for integrating a continuous glucose sensor , including a receiver , a medicament delivery device , a controller module, and optionally a single point glucose monitor are provided. Integration may be manual, semi-automated and/or fully automated. 1. An integrated system for monitoring a glucose concentration in a host and for delivering insulin to the host , the system comprising:a continuous glucose sensor, wherein the continuous glucose sensor is configured to substantially continuously measure a glucose concentration in a host, and to provide sensor data associated with the glucose concentration of the host;an electronics module comprising a bolus controller module configured to iteratively determine an insulin therapy instruction in response to an evaluation of a relationship of internally derived data and an engageable bolus constraint, wherein a relationship of internally derived data to the bolus constraint is evaluated in response to engagement of the bolus constraint, and wherein the bolus constraint comprises a maximum total insulin dose that can be delivered within a predefined time period in response to engagement of the bolus constraint; andan insulin delivery device configured to deliver insulin to the host, wherein the insulin delivery device is at least one of physically connected to a receiver and/or operably connected to a receiver, and wherein the insulin delivery device is configured to receive the insulin therapy instruction from the controller module.2. The integrated system of claim 1 , wherein the insulin therapy instruction is determined solely on internally derived data and the bolus constraint.3. The integrated system of claim 1 , wherein the system further comprises at least one of a selectable button configured to allow a user to engage the engageable bolus constraint claim 1 , a scroll wheel configured to allow a user to engage the engageable bolus constraint claim 1 , or a menu selection configured to allow a user ...

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Номер записи: 89
20-02-2014 дата публикации

INTEGRATED INSULIN DELIVERY SYSTEM WITH CONTINUOUS GLUCOSE SENSOR

Номер: US20140052093A1
Автор: Brauker James H., Dobbles John Michael, Kamath Apurv Ullas, Mahalingam Aarthi
Принадлежит: DexCom, Inc.

Systems and methods for integrating a continuous glucose sensor , including a receiver , a medicament delivery device , a controller module, and optionally a single point glucose monitor are provided. Integration may be manual, semi-automated and/or fully automated. 1. A method for diabetes management , the method comprising:controlling insulin delivery to a host, using a processor comprising a controller module;iteratively evaluating internally derived data relative to a predetermined glucose boundary; andselectively turning the controller on or off responsive to the iterative evaluation.2. The method of claim 1 , wherein the internally derived data comprises processed glucose data.3. The method of claim 2 , wherein the selectively turning the controller on or off comprises selectively turning the insulin delivery off when the processed glucose sensor data meets a predetermined criterion relative to the predetermined glucose boundary.4. The method of claim 3 , wherein the predetermined criterion for selectively turning the controller module off comprises the host's glucose falling below the glucose boundary.5. The method of claim 2 , wherein the selectively turning the controller on or off comprises selectively turning the insulin delivery on when the processed glucose sensor data meets a predetermined criterion relative to the predetermined glucose boundary.6. The method of claim 5 , wherein the predetermined criterion for selectively turning the controller module on comprises the host's glucose surpassing the glucose boundary.7. The method of claim 1 , wherein the predetermined glucose boundary comprises a set point.8. The method of claim 7 , wherein the predetermined glucose boundary comprises more than one set point.9. The method of claim 8 , wherein the more than one set point comprises a first set point to select the on instruction and a second set point to select the off instruction.10. The method of claim 1 , wherein the processed glucose sensor data is ...

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Номер записи: 90
20-02-2014 дата публикации

Integrated insulin delivery system with continuous glucose sensor

Номер: US20140052094A1
Автор: Aarthi Mahalingam, Apurv Ullas Kamath, James H. Brauker, John Michael Dobbles
Принадлежит: Dexcom Inc

Systems and methods for integrating a continuous glucose sensor 12 , including a receiver 14 , a medicament delivery device 16 , a controller module, and optionally a single point glucose monitor 18 are provided. Integration may be manual, semi-automated and/or fully automated.

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Номер записи: 91
20-02-2014 дата публикации

INTEGRATED INSULIN DELIVERY SYSTEM WITH CONTINUOUS GLUCOSE SENSOR

Номер: US20140052095A1
Автор: Brauker James H., Dobbles John Michael, Kamath Apurv Ullas, Mahalingam Aarthi
Принадлежит: DexCom, Inc.

Systems and methods for integrating a continuous glucose sensor , including a receiver , a medicament delivery device , a controller module, and optionally a single point glucose monitor are provided. Integration may be manual, semi-automated and/or fully automated. 1. A method for diabetes management of a host , the method comprising:receiving sensor data generated by a continuous glucose monitoring device, wherein the sensor data is indicative of a glucose concentration;determining an insulin therapy instruction, using a controller module of a processor, based on the sensor data and a system error; anddelivering insulin, using an insulin infusion device, to the host based on the insulin therapy instruction from the controller module.2. The method of claim 1 , wherein the sensor data comprises at least one of a glucose concentration claim 1 , a change in glucose concentration claim 1 , a rate of change of glucose concentration claim 1 , an acceleration of a rate of change of glucose concentration claim 1 , a deceleration of a rate of change of glucose concentration claim 1 , a direction of a change in glucose concentration claim 1 , a predicted glucose concentration for a future time claim 1 , an estimated glucose concentration claim 1 , a possible variation of glucose concentration claim 1 , or glucose concentration trend information.3. The method of claim 2 , wherein the sensor data comprises the possible variation of glucose concentration based on the system error.4. The method of claim 1 , comprising monitoring an error associated with the system claim 1 , whereby the system error is determined.5. The method of claim 4 , comprising iteratively evaluating the determined system error over time and adjusting one or more system parameters based on the iterative evaluation.6. The method of claim 5 , wherein the one or more system parameters are selected from the group consisting of target range claim 5 , glucose boundary claim 5 , bolus constraint claim 5 , basal ...

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Номер записи: 92
27-02-2014 дата публикации

ANALYTE SENSOR

Номер: US20140058235A1
Автор: Brister Mark C., Kamath Apurv Ullas, LI Ying, Yang Richard C.
Принадлежит: DexCom, Inc.

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system. 1. A method for evaluating a change in a sensitivity of an implanted analyte sensor over a predetermined time period , comprising:receiving sensor data from an analyte sensor implanted in a host, wherein the implanted sensor is configured to generate sensor data, wherein the sensor data comprises one or more sensor analyte values measured in a biological sample of a host;intermittently calculating a sensitivity of the analyte sensor; andevaluating, using an electronic device, a change in sensitivity by evaluating a plurality of time-spaced sensitivity calculations over a predetermined time period, wherein evaluating a change in sensitivity is based at least in part on using a priori sensitivity information throughout a sensor session, wherein the plurality of time spaced sensitivity calculations are not based on a blood-glucose measurement.2. The method of claim 1 , wherein the predetermined time period is less than or equal to about 30 minutes.3. The method of claim 1 , wherein the predetermined time period is less than or equal to about 20 minutes.4. The method of claim 1 , wherein the predetermined time period is less than or equal to about 10 minutes.5. The method of claim 1 , wherein evaluating a change in sensitivity comprises evaluating at least two sensitivity measurements during the predetermined time period.6. The method of claim 5 , further comprising averaging and/or filtering the at least two sensitivity measurements prior to evaluating the at least two sensitivity measurements.7. The method of claim 1 , wherein evaluating a change in sensitivity comprises comparing the change in sensitivity with one or more criteria.8. The method ...

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Номер записи: 93
27-03-2014 дата публикации

MULTIPLE ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR, AND RELATED METHODS

Номер: US20140088389A1
Автор: Bohm Sebastian, Boock Robert J., Simpson Peter C., Wightlin Matthew D., ZHANG Huashi
Принадлежит: DexCom, Inc.

In one embodiment, a continuous analyte sensor having more than one working electrode, and configured to reduce or eliminate crosstalk between the working electrodes. In another embodiment, a continuous analyte sensor having more than one working electrode, and configured so that a membrane system has equal thicknesses over each of the electrodes, despite having differing numbers of layers over each of the electrodes. In another embodiment, a configuration for connecting a continuous analyte sensor to sensor electronics. In another embodiment, methods for forming precise windows in an insulator material on a multi-electrode assembly. In another embodiment, a contact assembly for a continuous analyte sensor having more than one working electrode. 1. A continuous analyte sensor , comprising:a first working electrode;a second working electrode; anda membrane overlying at least a portion of the sensor, including the first and second working electrodes, the membrane being continuous, but for a first portion located between the first and second working electrodes that has properties that differ from properties of other portions of the membrane.2. The continuous analyte sensor of claim 1 , wherein at least one of the properties is permeability.3. The continuous analyte sensor of claim 2 , wherein the first portion is cross-linked.4. The continuous analyte sensor of claim 2 , wherein the other portions are cross-linked claim 2 , and the first portion is cross-linked by an amount different from the other portions.5. The continuous analyte sensor of claim 2 , wherein the first portion has a lower content of a hydrophilic species than the other portions.6. The continuous analyte sensor of claim 5 , wherein the hydrophilic species is removed by a secondary removal process claim 5 , a leaching process claim 5 , or a precipitation process involving heat claim 5 , pH claim 5 , or solvents.7. The continuous analyte sensor of claim 1 , wherein the first portion comprises a ...

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Номер записи: 94
27-03-2014 дата публикации

Analyte Sensor

Номер: US20140088391A1
Автор: Brister Mark, Leach Jacob S., Simpson Peter C., Yang Richard C.
Принадлежит: DexCom, Inc.

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system. 1. An integrated sensor system for measuring an analyte in a sample of a host and for fluid infusion into the host , comprising:an analyte sensor configured and arranged for measuring an analyte concentration in a biological sample of a circulatory system of a host;a vascular access device;tubing assembly comprising tubing; anda flow control device configured to regulate exposure of the analyte sensor to a biological sample and to a reference solution according to a flow profile, wherein the flow control device comprises a valve, and wherein the valve is configured and arranged with a gravity flow position and a controlled flow position.2. The system of claim 1 , wherein the system is configured such that the analyte sensor is flushed by the reference solution when the valve is in the gravity flow position.3. The system of claim 2 , wherein the gravity flow position comprises a first flow rate of the solution claim 2 , wherein the controlled flow position comprises a second flow rate of the solution claim 2 , and wherein a ratio of the first flow rate to the second flow rate is at least about 10:1.4. The system of claim 3 , wherein the gravity flow position has a flow rate of at least about 600 ml/hr.5. The system of claim 3 , wherein the controlled flow position has a flow rate of from about 0.5 ml/hr to about 4.0 ml/hour.6. The system of claim 1 , wherein the valve is configured and arranged to receive the tubing in a substantially linear configuration.7. The system of claim 6 , wherein the valve and the tubing assembly are configured and arranged such that the tubing is in a stretched state after installation of the tubing in the valve.8. ...

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Номер записи: 95
03-04-2014 дата публикации

RECEIVERS FOR ANALYZING AND DISPLAYING SENSOR DATA

Номер: US20140091940A1
Автор: Chico Holly, Constantine Kassandra, Hall Thomas, Hampapuram Hari, JOHNSON Eric, Mensinger Michael Robert, Reihman Eli, Simpson Peter C., Snisarenko Kostyantyn
Принадлежит: DexCom, Inc.

This disclosure provides systems, methods and apparatus for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor. The system may include a display device with at least one input device. In response to movement of or along the input device, the display device may change a glucose data output parameter and update an output of the display device using the changed output parameter. 120-. (canceled)21. The method for presenting an interactive glucose chart on a display device , comprising:displaying on a touch-sensitive display of a computing device a glucose trend chart displaying monitored glucose levels of a host over a first time range; anddisplaying on the display a navigation bar simultaneously with the glucose trend chart, the navigation bar displaying a graph of the monitored glucose levels of the host over a second time range that is greater than and encompasses the first time range, wherein predetermined user interaction with the navigation bar detected by the computing device changes the first time range of glucose data.22. The method of claim 21 , wherein the navigation bar is positioned adjacent to the glucose trend chart on the display.23. The method of claim 21 , wherein the navigation bar includes an indication of the first time range.24. The method of claim 23 , wherein the graph of the navigation bar displays the glucose data encompassed by the first time range differently than the glucose data not encompassed by the first time range.25. The method of claim 24 , wherein the glucose data encompassed by the first time range displayed on the navigational bar is shaded differently than the data not encompassed by the first time range.26. The method of claim 23 , wherein the indication of the first time range includes a selectable slider bar that can be touched and dragged by a user across the navigational bar to change the first time range.27. The method of claim 23 , further comprising increasing a ...

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Номер записи: 96
03-04-2014 дата публикации

RECEIVERS FOR ANALYZING AND DISPLAYING SENSOR DATA

Номер: US20140091941A1
Автор: Chico Holly, Constantine Kasandra, Hall Thomas, Hampapuram Hari, JOHNSON Eric, Mensinger Michael Robert, Reihman Eli, Simpson Peter C., Snisarenko Kostyantyn
Принадлежит: DexCom, Inc.

This disclosure provides systems, methods and apparatus for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor. The system may include a display device with at least one input device. In response to movement of or along the input device, the display device may change a glucose data output parameter and update an output of the display device using the changed output parameter. 120-. (canceled)21. A glucose monitoring system for monitoring a host's glucose levels , the system comprising a computing device having a touch-sensitive display , wherein the computing device is configured to:display on the touch-sensitive display a first chart and a second chart adjacent to one another, each chart having a y-axis in units of an analyte concentration and an x-axis in units of time, and each x-axis of the first and second charts extending different periods of time, wherein the x-axis of the first chart extends a first period of time and the x-axis of the second chart extends a second period of time, the first period of time being a sub-set of the second period of time, and wherein the second chart additionally comprises an indication of the first time period.22. The computing device of claim 21 , wherein the computing device is further configured to change the first time period in response to the computing device detecting a predefined user input.23. The computing device of claim 22 , wherein the predefined user input comprises a predefined user gesture on the user interface.24. The computing device of claim 23 , wherein the predefined user gesture comprises a tap on the display claim 23 , a swipe on the display claim 23 , or a selection and dragging of an icon on the display.25. The computing device of claim 21 , wherein the indication of the first time period comprises a bar extending along the y-axis of the second chart claim 21 , and wherein the bar moves along the x-axis of the second chart responsive to a user changing ...

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Номер записи: 97
03-04-2014 дата публикации

ZWITTERION SURFACE MODIFICATIONS FOR CONTINUOUS SENSORS

Номер: US20140094671A1
Автор: Boock Robert J., Dring Chris W.
Принадлежит: DexCom, Inc.

Devices are provided for measurement of an analyte concentration, e.g., glucose in a host. The device can include a sensor configured to generate a signal associated with a concentration of an analyte; and a sensing membrane located over the sensor. The sensing membrane comprises a diffusion resistance domain configured to control a flux of the analyte therethrough. The diffusion resistance domain comprises one or more zwitterionic compounds and a base polymer comprising both hydrophilic and hydrophobic regions. 1. A device for measurement of an analyte concentration , the device comprising:a sensor configured to generate a signal associated with a concentration of an analyte; anda sensing membrane located over the sensor, the sensing membrane comprising a diffusion resistance domain configured to control a flux of the analyte therethrough, wherein the diffusion resistance domain comprises a base polymer and one or more zwitterionic compounds, and wherein the base polymer comprises both hydrophilic and hydrophobic regions.2. The device of claim 1 , wherein an amount of the one or more zwitterionic compounds in the diffusion resistance domain is less than about 10% wt. of the resistance domain.3. The device of claim 1 , wherein an amount of the one or more zwitterionic compounds in the diffusion resistance domain is less than about 5% wt. of the resistance domain.4. The device of claim 1 , wherein the one or more zwitterionic compounds comprise a betaine compound or derivative thereof.5. The device of claim 1 , wherein the one or more zwitterionic compounds comprise at least one compound selected from the group consisting of a carboxyl betaine compound claim 1 , a sulfo betaine compound claim 1 , a phosphor betaine compound claim 1 , and derivatives thereof.6. The device of claim 1 , wherein the one or more zwitterionic compounds comprise at least one compound selected from the group consisting of cocamidopropyl betaine claim 1 , oleamidopropyl betaine claim 1 , ...

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Номер записи: 98
03-04-2014 дата публикации

RECEIVERS FOR ANALYZING AND DISPLAYING SENSOR DATA

Номер: US20140094673A1
Автор: Chico Holly, Constantine Kassandra, Hall Thomas, Hampapuram Hari, JOHNSON Eric, Mensinger Michael Robert, Reihman Eli, Simpson Peter C., Snisarenko Kostyantyn
Принадлежит: DexCom, Inc.

This disclosure provides systems, methods and apparatus for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor. The system may include a display device with at least one input device. In response to movement of or along the input device, the display device may change a glucose data output parameter and update an output of the display device using the changed output parameter. 120-. (canceled)22. The method of claim 21 , wherein changing the time period comprises receiving user input indicative of a request to change the time period.23. The method of claim 21 , wherein the associated event is selected from the group consisting of food claim 21 , insulin claim 21 , exercise claim 21 , sleep claim 21 , and illness.24. A method for displaying glucose information to a user using a hand-held computing device claim 21 , comprising:displaying on a touch-sensitive display of a computing device a glucose chart including a trend line indicative of a glucose level of a host over a first time period;displaying one or more event indicators on the chart, each event indicator positioned on the chart to indicate when an associated event occurred in time; andadding an indicator to the chart in response to the computing device detecting a predefined user input.25. The method of claim 24 , wherein the predefined user input comprises touching a selected portion of the glucose chart.26. The method of claim 24 , wherein the associated event is selected from the group consisting of food claim 24 , insulin claim 24 , exercise claim 24 , sleep claim 24 , and illness.27. A method for displaying glucose information to a user using a hand-held computing device claim 24 , comprising:displaying on a touch-sensitive display of a computing device a glucose chart including a trend line indicative of a glucose level of a host over a first time period;displaying one or more event indicators on the chart, each event indicator positioned on the chart ...

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Номер записи: 99
03-04-2014 дата публикации

ANALYTE DATA RETRIEVER

Номер: US20140095577A1
Автор: Greene Adam R., Root Daniel N., Schumacher Justin E., Shields Stewart Alan
Принадлежит: DexCom, Inc.

Methods and apparatus, including computer program products, are provided for processing analyte data. In some example implementations, a method may include receiving, at a first processing system including a user interface, an installation package including a plug-in and code configured to provide at the first processing system an interface between a sensor system configured to measure an analyte concentration level in a host and a second processing system; storing, by the first processing system, the installation package in a location based on a role of a user initiating the installation of the code; installing the plug-in for the user interface to enable the plug-in to control one or more aspects of an installation of the code; and initiating, by at least the plug-in, the installation of the code at the first processing system to provide the interface. Related systems, methods, and articles of manufacture are also disclosed. 1. A method comprising:retrieving, using a first processing system comprising an interface, analyte sensor data from an analyte sensor system configured to measure an analyte concentration level in a host; andforwarding, by the interface, the received analyte sensor data as a pass-through by at least forwarding the received analyte sensor data to a second processing system coupled to the interface via a network including an internet, wherein the pass-through comprises forwarding the received analyte sensor data without storing the received analyte sensor data in a persistent storage at the first processing system comprising the interface.2. The method of claim 1 , wherein the first processing system further comprises a display for presenting the analyte sensor data claim 1 , and wherein the first processing system couples to the sensor system via a first encrypted connection and further couples through a second encrypted connection to the second processing system claim 1 , wherein the second processing system authorizes the first encrypted ...

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Номер записи: 100