12-04-2012 дата публикации
Номер: US20120087938A1
Принадлежит:
The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens. 196-. (canceled)97. An isolated protein comprising the sequence of amino acids set forth in , , , , , , , , , , , , , , , , or .98. A nucleic acid comprising a nucleotide sequence that encodes the protein according to .99. The nucleic acid according to wherein the protein comprises the sequence of amino acids set forth in claim 98 , claim 98 , claim 98 , claim 98 , claim 98 , claim 98 , claim 98 , claim 98 , claim 98 , claim 98 , claim 98 , or .100. The nucleic acid according to wherein said nucleic acid comprises the nucleotide sequence set forth in claim 99 , claim 99 , claim 99 , claim 99 , claim 99 , claim 99 , claim 99 , claim 99 , claim 99 , claim 99 , claim 99 , or .101. A nucleic acid comprising a nucleotide sequence encoding:CON6 HIV gp160 protein,subtype C ancestral HIV envelope protein,subtype C consensus HIV envelope protein,subtype C consensus HIV gag protein,subtype C consensus HIV nef protein,Group M consensus HIV envelope protein,subtype A consensus HIV envelope protein,Group M consensus HIV gag protein,Group M consensus HIV pal protein,Group M consensus HIV nef protein,subtype C consensus HIV pol protein,subtype B consensus HIV gag protein, orsubtype B consensus HIV envelope proteinwherein said nucleotide sequence comprises codons optimized for expression in human cells.102. The nucleic acid according to wherein said nucleic acid comprises the nucleotide sequence set forth in claim 101 , claim 101 , claim 101 , claim 101 , claim 101 , claim 101 , claim 101 , claim 101 , claim ...
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