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Применить Всего найдено 13. Отображено 13.
19-09-2017 дата публикации

Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise

Номер: US9763609B2
Принадлежит: DEXCOM INC, DexCom, Inc.

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

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23-05-2013 дата публикации

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Номер: US20130131478A1
Принадлежит: DexCom, Inc.

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 1. An electrochemical continuous glucose sensor configured for implantation in a host , the glucose sensor comprising:an electrode configured to measure a signal indicative of a glucose concentration of a host, wherein the signal comprises a glucose-related component and a non-glucose related component; anda membrane covering at least a portion of the electrode, wherein the membrane is configured to reduce passage of an interfering species therethrough, whereby the non-glucose-related component of the signal is less than about 20% of the signal over a period of at least one day;wherein the glucose sensor has a sensitivity to glucose of from about 25 pA/mg/dL to about 500 pA/mg/dL.2. The glucose sensor of claim 1 , wherein the interfering species has an oxidation potential that overlaps with an oxidation potential of a measured species indicative of the concentration of the analyte.3. The glucose sensor of claim 1 , wherein the measured species is a product of an enzymatic reaction between glucose and an enzyme and is measured by the electrode.4. The glucose sensor of claim 1 , wherein the membrane comprises a silicone-containing polymer.5. The glucose sensor of claim 4 , wherein the silicone-containing polymer is a polysiloxanes.6. The glucose sensor of claim 4 , wherein the silicone-containing polymer is a polycarbosiloxane.7. The glucose sensor of wherein the silicone-containing polymer is a copolymer comprising a silicone segment and a polyurethane segment.8. The glucose sensor of claim 1 , wherein the membrane comprises a fluorocarbon-based material.9. The glucose sensor of claim 1 , wherein the non-glucose-related component ...

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06-02-2020 дата публикации

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Номер: US20200037874A1
Принадлежит:

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 126-. (canceled)27. A transcutaneous electrochemical glucose sensor configured for implantation in a host , the transcutaneous electrochemical glucose sensor comprising:a first portion configured to remain outside a body of the host during sensor use; and a working electrode comprising a plurality of sensing regions; and', 'a reference electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor., 'a second portion configured to be inserted inside the body of the host during sensor use, wherein the second portion comprises28. The transcutaneous electrochemical glucose sensor of claim 27 , wherein the membrane comprises a layer configured to control a diffusion of glucose therethrough.29. The transcutaneous electrochemical glucose sensor of claim 27 , wherein the layer comprises polyurethane.30. The transcutaneous electrochemical glucose sensor of claim 27 , wherein the transcutaneous electrochemical glucose sensor has a planar shape.31. The transcutaneous electrochemical glucose sensor of claim 27 , wherein the reference electrode further comprises silver and silver chloride.32. The transcutaneous electrochemical glucose sensor of claim 27 , further comprising a counter electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor.33. The transcutaneous electrochemical sensor of claim 27 , wherein each of the plurality of sensing regions comprises a membrane.34. The transcutaneous electrochemical sensor of claim 33 , wherein the membrane comprises an enzyme.35. The transcutaneous electrochemical sensor of claim 33 , wherein the ...

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06-02-2020 дата публикации

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Номер: US20200037875A1
Принадлежит:

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 120-. (canceled)21. A transcutaneous electrochemical glucose sensor configured for implantation in a host , the transcutaneous electrochemical glucose sensor comprising:a first portion configured to remain outside a body of the host during sensor use, wherein the first portion is configured to operably connect with sensor electronics; and a planar substrate;', 'a working electrode disposed over at least a portion of the planar substrate;', 'a membrane layer disposed over at least a portion of the working electrode; and', 'a reference electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor,, 'a second portion configured to be inserted inside the body of the host during sensor use, wherein the second portion comprises22. The transcutaneous electrochemical glucose sensor of claim 21 , wherein the membrane layer is configured to control a diffusion of glucose therethrough.23. The transcutaneous electrochemical glucose sensor of claim 21 , wherein the membrane layer comprises polyurethane.24. The transcutaneous electrochemical glucose sensor of claim 21 , wherein the transcutaneous electrochemical glucose sensor has a planar shape.25. The transcutaneous electrochemical glucose sensor of claim 21 , wherein the reference electrode comprises silver and silver chloride.26. The transcutaneous electrochemical glucose sensor of claim 21 , further comprising a counter electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby ...

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08-05-2014 дата публикации

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Номер: US20140128703A1
Принадлежит: DexCom, Inc.

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 120-. (canceled)21. An electrochemical continuous glucose sensor configured for implantation in a host , the glucose sensor comprising:an electrode comprising a plurality of electroactive surfaces each configured to measure a signal indicative of a glucose concentration of a host; anda membrane covering at least a portion of the electrode, wherein the membrane comprises an enzyme configured to react with glucose.22. The glucose sensor of claim 21 , wherein each of the electroactive surfaces is shaped like a circle.23. The glucose sensor of claim 21 , wherein each of the electroactive surfaces is shaped like a dot.24. The glucose sensor of claim 21 , wherein the plurality of electroactive surfaces all have a substantially equal area.25. The glucose sensor of claim 21 , wherein the plurality of electroactive surfaces are each spaced apart from at least one adjacent electroactive surface by a substantially equal distance.26. The glucose sensor of claim 21 , wherein the plurality of electroactive surfaces are spaced along a substantial length of an in vivo portion of the glucose sensor.27. The glucose sensor of claim 21 , wherein the membrane comprises a layer configured to control a diffusion of glucose therethrough claim 21 , wherein the layer comprises polyurethane.28. The glucose sensor of claim 21 , wherein the glucose sensor has a planar shape.29. The glucose sensor of claim 21 , wherein the plurality of electroactive surfaces comprise at more than two electroactive surfaces.30. The glucose sensor of claim 21 , wherein the plurality of electroactive surfaces comprise at more than three electroactive surfaces.31. The glucose ...

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08-05-2014 дата публикации

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Номер: US20140128704A1
Принадлежит: DexCom, Inc.

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 120-. (canceled)21. An electrochemical continuous glucose sensor configured for implantation in a host , the glucose sensor comprising:an electrode configured to measure a signal indicative of a glucose concentration of a host; anda membrane covering at least a portion of the electrode, wherein the membrane comprises a first domain configured to reduce passage of an interfering species therethrough and a second domain comprising an enzyme configured to react with glucose, wherein the first domain is configured to trap interfering species having a molecular weight equal to or greater than a molecular weight of acetaminophen and configured to prevent the interfering species from reaching the electrode, wherein the first domain is positioned between the second domain and the electrode.22. The glucose sensor of claim 21 , wherein the molecular weight is about 151 Daltons.23. The glucose sensor of claim 21 , wherein the interfering species has an oxidation potential that substantially overlaps with an oxidation potential of a measured species indicative of the concentration of the analyte.24. The glucose sensor of claim 23 , wherein the measured species is a product of an enzymatic reaction between glucose and an enzyme and is measured by the electrode.25. The glucose sensor of claim 21 , wherein the glucose sensor has a sensitivity to glucose of from about 25 pA/mg/dL to about 500 pA/mg/dL.26. The glucose sensor of claim 21 , wherein the membrane further comprises a third domain configured to reduce a flux of glucose therethough.27. The glucose sensor of claim 26 , wherein the third domain comprises a product of a reaction of an ...

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18-06-2020 дата публикации

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Номер: US20200187776A1
Принадлежит:

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 120-. (canceled)21. A transcutaneous electrochemical glucose sensor configured for implantation in a host , the transcutaneous electrochemical glucose sensor comprising:a first portion configured to remain outside a body of the host during sensor use, wherein the first portion is configured to operably connect with sensor electronics; and a working electrode configured for use in measuring a signal indicative of a glucose concentration of the host;', 'a membrane covering at least a portion of the working electrode; and', 'a reference electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor., 'a second portion configured to be inserted inside the body of the host during sensor use, wherein the second portion comprises22. The transcutaneous electrochemical glucose sensor of claim 21 , wherein the membrane comprises a layer configured to control a diffusion of glucose therethrough.23. The transcutaneous electrochemical glucose sensor of claim 22 , wherein the layer comprises polyurethane.24. The transcutaneous electrochemical glucose sensor of claim 21 , wherein the transcutaneous electrochemical glucose sensor has a planar shape.25. The transcutaneous electrochemical glucose sensor of claim 21 , wherein the reference electrode comprises silver and silver chloride.26. The transcutaneous electrochemical glucose sensor of claim 21 , further comprising a counter electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby ...

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07-11-2019 дата публикации

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Номер: US20190335997A1
Принадлежит:

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 1. An electrochemical continuous glucose sensor configured for implantation in a host , the glucose sensor comprising:an electrode configured to measure a signal indicative of a glucose concentration of a host, wherein the signal comprises a glucose-related component and a non-glucose related component; anda membrane covering at least a portion of the electrode, wherein the membrane is configured to reduce passage of an interfering species therethrough, whereby the non-glucose-related component of the signal is less than about 20% of the signal over a period of at least one day;wherein the glucose sensor has a sensitivity to glucose of from about 25 pA/mg/dL to about 500 pA/mg/dL.2. The glucose sensor of claim 1 , wherein the interfering species has an oxidation potential that overlaps with an oxidation potential of a measured species indicative of the concentration of the analyte.3. The glucose sensor of claim 1 , wherein the measured species is a product of an enzymatic reaction between glucose and an enzyme and is measured by the electrode.4. The glucose sensor of claim 1 , wherein the membrane comprises a silicone-containing polymer.5. The glucose sensor of claim 4 , wherein the silicone-containing polymer is a polysiloxanes.6. The glucose sensor of claim 4 , wherein the silicone-containing polymer is a polycarbosiloxane.7. The glucose sensor of wherein the silicone-containing polymer is a copolymer comprising a silicone segment and a polyurethane segment.8. The glucose sensor of claim 1 , wherein the membrane comprises a fluorocarbon-based material.9. The glucose sensor of claim 1 , wherein the non-glucose-related component ...

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24-12-2020 дата публикации

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Номер: US20200397291A1
Принадлежит:

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 1. An electrochemical continuous glucose sensor configured for implantation in a host , the glucose sensor comprising:an electrode configured to measure a signal indicative of a glucose concentration of a host, wherein the signal comprises a glucose-related component and a non-glucose related component; anda membrane covering at least a portion of the electrode, wherein the membrane is configured to reduce passage of an interfering species therethrough, whereby the non-glucose-related component of the signal is less than about 20% of the signal over a period of at least one day;wherein the glucose sensor has a sensitivity to glucose of from about 25 pA/mg/dL to about 500 pA/mg/dL.2. The glucose sensor of claim 1 , wherein the interfering species has an oxidation potential that overlaps with an oxidation potential of a measured species indicative of the concentration of the analyte.3. The glucose sensor of claim 1 , wherein the measured species is a product of an enzymatic reaction between glucose and an enzyme and is measured by the electrode.4. The glucose sensor of claim 1 , wherein the membrane comprises a silicone-containing polymer.5. The glucose sensor of claim 4 , wherein the silicone-containing polymer is a polysiloxanes.6. The glucose sensor of claim 4 , wherein the silicone-containing polymer is a polycarbosiloxane.7. The glucose sensor of wherein the silicone-containing polymer is a copolymer comprising a silicone segment and a polyurethane segment.8. The glucose sensor of claim 1 , wherein the membrane comprises a fluorocarbon-based material.9. The glucose sensor of claim 1 , wherein the non-glucose-related component ...

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11-10-2007 дата публикации

Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise

Номер: US20070235331A1
Принадлежит: Dexcom Inc

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

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29-01-2013 дата публикации

Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise

Номер: US8364229B2
Принадлежит: Dexcom Inc

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

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06-10-2020 дата публикации

Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise

Номер: US10791928B2
Принадлежит: Dexcom Inc

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

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13-08-2019 дата публикации

Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise

Номер: US10376143B2
Принадлежит: Dexcom Inc

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

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