08-07-2021 дата публикации
Номер: US20210206723A1
Принадлежит:
The present invention provides compounds of formula (I), formula (II) or formula (III), wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases. 2. The compound according to claim 1 , wherein:{'sup': 2', '2A, 'V is a bond or CRR;'}{'sub': 1', '4, 'W is —CH—, —C(C-Calkyl)-, or N;'}n is 1 or 2;{'sub': 8', '10', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6, 'sup': '6', 'A is C-Ccycloalkyl optionally substituted with one, two, or three substituents independently selected from: halo, OH, CN, C-Calkyl, —OC-Calkyl, and 5- to 6-membered heteroaryl optionally substituted with C-Calkyl; or 5- to 6-membered cycloheteroalkyl comprising carbon atoms and 1 to 2 heteroatoms selected from N and NR; said cycloheteroalkyl is optionally substituted with one, two, or three substituents independently selected from: halo, CN, C-Calkyl, —OC-Calkyl, and 5- to 6-membered heteroaryl optionally substituted with C-Calkyl;'}{'sub': 3', '10', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6, 'sup': '6', 'B is C-Ccycloalkyl optionally substituted with one, two, or three substituents independently selected from: halo, OH, CN, C-Calkyl, —OC-Calkyl, and 5- to 6-membered heteroaryl optionally substituted with C-Calkyl; or 5- to 6-membered cycloheteroalkyl comprising carbon atoms and 1 to 2 heteroatoms selected from N and NR; said cycloheteroalkyl is optionally substituted with one, two, or three substituents independently selected from: halo, CN, C-Calkyl, —OC-Calkyl, and 5- to 6-membered heteroaryl optionally substituted with C-Calkyl;'}{'sup': 1', '1A, 'sub': 3', '3', '3', '3, 'Rand Rare independently H, F, Cl, CH, CF, —OCH, or —OCF.'}{'sup': 2', '2A, 'sub': 1', '4, 'Rand Rare independently H or C-Calkyl;'}{'sup': 3', '4, 'sub': 1', '4, 'Rand Rare independently H or C-Calkyl ...
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