10-04-2014 дата публикации
Номер: US20140099371A1
A medicinal carrier is provided. The medicinal carrier comprises a first component, which is a biocompatible polymer with an amino group (—NH); a saccharide; and a second component which is a biocompatible material. The saccharide grafts to the first component via the amino group (—NH) of the first component, and the first component bonds to the second component via an ionic bond. The medicinal carrier can protect the medicine from gastric acid and swell or decompose to release the medicine under a specific pH condition, thus, showing a good applicability. 1. A medicinal carrier , comprising:{'sub': '2', 'a first component, which is a biocompatible polymer with an amino group (—NH);'}a saccharide, which is selected from the group consisting of glucose, fucose, galactosamine, mannose, and combinations thereof; anda second component, which is a biocompatible material;{'sub': '2', 'wherein the saccharide grafts to the first component via the amino group (—NH) of the first component and the first component bonds to the second component via ionic bond.'}2. The carrier as claimed in claim 1 , wherein the first component is selected from the group consisting of chitosan claim 1 , collagen claim 1 , gelatin claim 1 , ethylene glycol-chitosan claim 1 , poly(ethylene glycol)-chitosan claim 1 , and combinations thereof and the second component is selected from the group consisting of heparin claim 1 , poly(glutamic acid) claim 1 , tripolyphosphoric acid claim 1 , poly(acrylic acid) claim 1 , phospholipid claim 1 , sodium alginate claim 1 , tea polyphenol claim 1 , and combinations thereof.3. The carrier as claimed in claim 2 , wherein the first component is selected from the group consisting of chitosan claim 2 , gelatin claim 2 , and combinations thereof; the second component is selected from the group consisting of heparin claim 2 , poly(glutamic acid) claim 2 , sodium alginate claim 2 , catechin claim 2 , and combinations thereof; and the saccharide is fucose.4. The carrier ...
Подробнее