02-02-2017 дата публикации
Номер: US20170029902A1
Принадлежит:
In particular, disclosed is a method for treating a patient with prostate cancer that involves genotyping a nucleic acid sample from the subject for one or more single nucleotide polymorphism (SNP) alleles in one or more genes angiogenesis, comparing the one or more SNP alleles to control allele frequencies to produce a SNP signature, and analyzing the SNP signature to generate a risk score. The risk score can represent the likelihood that the patient's prostate cancer will recur following radical prostatectomy. In particular embodiments, a high risk score in a patient with positive margins is an indication of a high risk of prostate cancer recurrence. 1. A method for treating a patient with prostate cancer , comprisinga) genotyping a nucleic acid sample from the subject for one or more single nucleotide polymorphism (SNP) alleles in angiogenesis genes selected from the group consisting of ANGPT1, CACNA1C, CDH12, CDH13, CDH6, COL4A3, DDI1, ELK3, FBLN1, FGF12, FGF2, FGFR2, FN1, HDAC3, ID3, IGF2, IL16, IL1A, IL6, ITGA9, ITGAV, ITGB2, ITGB3, LECT1, LZTS1, MAP3K7IP2, MMP15, MMP16, MMP28, NCOA3, NOS2, NRP1, P2RY5, PDGFRB, PGE PTK2, ROBO1, RSPO3, SAMD14, STAB1, TEK, TFP1, TGFB2, THBS2, and TYR;b) comparing the one or more SNP alleles to control allele frequencies to produce a SNP signature;c) analyzing the SNP signature to generate a risk score;d) prescribing adjuvant therapy if the patient has a high risk score for recurrence, and not prescribing adjuvant therapy if the patient has a low risk score for recurrence.2. The method of claim 1 , wherein the patient has undergone radical prostatectomy.3. The method of claim 2 , wherein the patient has positive margins after the radical prostatectomy.4. The method of any one of to claim 2 , wherein step a) comprises genotyping the nucleic acid sample for at least 10 SNP alleles in the angiogenesis genes.5. The method of any one of to claim 2 , wherein step a) comprises genotyping the nucleic acid sample for one or more SNP ...
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