18-06-2015 дата публикации
Номер: US20150166559A1
Автор:
Cao Shousong,
Han Yongxin,
Huang Yuanyuan,
Li Yuliang,
Luo Hong,
Peng Yong,
Wang He,
Wang Huting,
Wang Zhe,
Xiao Dengming,
ZHANG Hul,
Zhao Ruiyu,
ZHU Yan
Принадлежит:
The present disclosure relates to a compound of formula I, a pharmaceutical composition thereof and the use thereof as an anti-tumor drug. 2. The compound according to claim 1 , wherein:{'sub': 1', '2', '3', '4', '5', '1-6', '1-6', '1-6', '3-8', '1-6, 'R, R, R, Rand Rare independently selected from the group consisting of hydrogen, halogen, hydroxy, Calkoxy, amino, mono (Calkyl) amino, di (Calkyl) amino, Ccycloalkyl amino, mercapto, Calkylthio or cyano; or'}{'sub': 3', '4', '4', '5', '5', '1, 'both Rand R, both Rand R,or both Rand R,together with the carbon atoms which they link to form a 5- to 7-membered non-aromatic ring having 0 to 3 heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur; or'}a pharmaceutically acceptable salt, solvate, polymorph, tautomer or prodrug thereof.3. The compound according to claim 1 , wherein:{'sub': 1', '2', '3', '4', '5', '1-6', '1-6', '1-6', '1-6, 'R, R, R, R, and Rare independently selected from the group consisting of hydrogen, hydroxy, Calkoxy, amino, mono (Calkyl) amino, di (Calkyl) amino, mercapto, or Calkylthio; or'}a pharmaceutically acceptable salt, solvate, polymorph, tautomer or prodrug thereof.4. The compound according to claim 1 , wherein:{'sub': 1', '2, 'Rand Rare both hydrogen;'}{'sub': 3', '4', '5', '1-6', '1-6', '1-6, 'R, R, and Rare independently selected from the group consisting of hydrogen, hydroxy, Calkoxy, amino, mono (Calkyl) amino, or di (Calkyl) amino; or'}a pharmaceutically acceptable salt, solvate, polymorph, tautomer or prodrug thereof.7. The compound according to claim 6 , wherein:{'sub': 4', '5', '1', '2', '3', '1-6', '1-6', '1-6', '3-8, 'both Rand Rtogether with the carbon atoms which they link to form a 5- to 7-membered non-aromatic ring having one heteroatom selected from the group consisting of nitrogen, oxygen, or sulfur, and R, Rand Rare independently selected from the group consisting of hydrogen, halogen, hydroxy, Calkoxy, amino, mono (Calkyl) amino, di (Calkyl) amino, ...
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