28-01-2021 дата публикации
Номер: US20210024546A1
The invention provides new heterocyclic compounds having the general formula (Ie) 139-. (canceled)49. The compound of claim 40 , or a pharmaceutically acceptable salt thereof claim 40 , wherein Ris hydrogen.50. The compound claim 40 , or a pharmaceutically acceptable salt thereof claim 40 , wherein Ris selected from the group consisting of hydrogen and halogen.51. The compound of claim 40 , wherein Ris selected from the group consisting of hydrogen and Cl.52. The compound of claim 40 , or a pharmaceutically acceptable salt thereof claim 40 , wherein Ris selected from the group consisting of hydrogen and halogen.53. The compound of claim 40 , or a pharmaceutically acceptable salt thereof claim 40 , wherein Ris selected from the group consisting of hydrogen claim 40 , F and Cl.54. The compound of claim 40 , or a pharmaceutically acceptable salt thereof claim 40 , wherein Ris hydrogen.55. The compound of claim 40 , or a pharmaceutically acceptable salt thereof claim 40 , wherein Ris hydrogen.56. The compound of claim 40 , or a pharmaceutically acceptable salt thereof claim 40 , wherein Ris selected from the group consisting of hydrogen claim 40 , F claim 40 , methoxy claim 40 , and hydroxy.57. The compound of claim 40 , or a pharmaceutically acceptable salt thereof claim 40 , wherein:{'sup': '2', 'Ris hydrogen;'}{'sup': '3', 'Ris selected from the group consisting of hydrogen and halogen;'}{'sup': '4', 'Ris selected from the group consisting of hydrogen and halogen;'}{'sup': '5', 'Ris hydrogen;'}{'sup': '6', 'Ris hydrogen; and'}{'sup': '7', 'Ris selected from the group consisting of hydrogen, F, methoxy, and hydroxy.'}61. The compound of claim 40 , selected from the group consisting of:[(7R,9aR)-7-(4-chlorophenyl)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl]-(3-phenoxyphenyl)methanone;[(7R,9aR)-7-(4-chlorophenyl)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl]-(2-chloro-3-methylphenyl)methanone;[(7R,9aR)-7-(4-chlorophenyl)-1,3,4,6,7,8,9,9a-octahydropyrido[ ...
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