17-11-2016 дата публикации
Номер: US20160333021A1
Автор:
Mihir Mandal,
Haifeng Tang,
Li Xiao,
Jing Su,
Guoqing Li,
Shu-Wei Yang,
Weidong Pan,
Haiqun Tang,
Reynalda DeJesus,
Jacqueline Hicks,
Matthew Lombardo,
Hong Chu,
William Hagmann,
Alex Pasternak,
Xin Gu,
Jinlong Jiang,
Shuzhi Dong,
Fa-Xiang Ding,
Clare London,
Dipshikha Biswas,
Katherine Young,
David N. Hunter,
Zhiqiang Zhao,
Dexi Yang,
MANDAL MIHIR,
TANG HAIFENG,
XIAO LI,
SU JING,
LI GUOQING,
YANG SHU-WEI,
PAN WEIDONG,
TANG HAIQUN,
DEJESUS REYNALDA,
HICKS JACQUELINE,
LOMBARDO MATTHEW,
CHU HONG,
HAGMANN WILLIAM,
PASTERNAK ALEX,
GU XIN,
JIANG JINLONG,
DONG SHUZHI,
DING FA-XIANG,
LONDON CLARE,
BISWAS DIPSHIKHA,
YOUNG KATHERINE,
HUNTER DAVID N,
ZHAO ZHIQIANG,
YANG DEXI,
Mandal Mihir,
Tang Haifeng,
Xiao Li,
Su Jing,
Li Guoqing,
Yang Shu-Wei,
Pan Weidong,
Tang Haiqun,
DeJesus Reynalda,
Hicks Jacqueline,
Lombardo Matthew,
Chu Hong,
Hagmann William,
Pasternak Alex,
Gu Xin,
Jiang Jinlong,
Dong Shuzhi,
Ding Fa-Xiang,
London Clare,
Biswas Dipshikha,
Young Katherine,
Hunter David N.,
Zhao Zhiqiang,
Yang Dexi
The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance. 2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 ,wherein:{'sup': 2', 'B, 'Xis N or CR;'}{'sup': 3', 'C, 'Xis N or CR;'}{'sup': 4', 'D, 'Xis N or CR;'}{'sup': 2', '3', '4, 'wherein no more than 2 of X, X, and Xare N;'}Z is tetrazolyl, wherein Z is linked to the six membered ring through a carbon to carbon bond;{'sup': A', 'a', 'a', 'b', 'a', 'a', 'A', 'A', 'a', 'b', 'a', 'b', 'a', 'b', 'a', 'b, 'sub': 1', '6', '2', '0-3', '3', '8', '3', '1', '6', '2', '0-3', '2', '0-3', '2', '0-1', '2', '1-2', '3', '8', '2', '1-2', '2', '2', '1', '6', '3', '5', '1', '6', '3', '7', '3', '2', '0-3', '2', '1', '6', '2', '1', '6', '2', '3', '6', '2, 'Ris H, C-Calkyl, —(CH)—C-Ccycloalkyl, —CF, C-Calkoxy, —COOR, —CN, —NRR, —(CH)HetA, —(CH)-AryA, —(CH)—O-AryA, —NR(CH)—C-Ccycloalkyl, —NR(CH)-phenyl, —C≡C-pyridinyl, —C≡C—CH-HetC, or —C≡C—CH—O-HetC; wherein the RC-Calkyl or any RC-Ccycloalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from C-Calkoxy, C-Ccycloalkyl, —OH, F, —CF, —CN, —(CH)NRR, —CONRR, —NHCONRR, —NHSO—C-Calkyl, —SO—C-Calkyl, —SO—C-Ccycloalkyl, —SONRR, AryB, and HetB;'}{'sup': B', 'a', 'b', 'B', 'a', 'b', 'a', 'b, 'sub': 1', '6', '1', '6', '1', '6', '3', '1', '6, 'Ris H, C-Calkyl, —OH, C-Calkoxy, —CN, F, Cl, Br, or —NRR, wherein the RC-Calkyl is optionally be substituted with 1, 2 or 3 substituents selected from —OH, —F, —NRR, —CF, C-Calkoxy, and —CONRR;'}{'sup': A', 'B', 'd, 'or Rand Rtogether with the atom(s) to which they are attached form a 5-7 membered fused ring containing 0, 1, or 2 heteroatoms independently selected from N, O and S, wherein N is optionally substituted with R;'}{'sup': 'C', 'sub': 1', '6', '3', '3', '2, 'Ris H, C-Calkyl, F, Cl, —CF, —COOCH, —C(O)NH, or AryC;'}{'sup': D ...
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