13-03-2014 дата публикации
Номер: US20140073524A1
Concentrations of certain miRNA, mRNA and/or protein markers in the biological fluids and/or tissues of a subject are used to determine the probability that the subject does or does not have Posttraumatic Stress Disorder (PTSD). The concentrations of these markers in fluids and/or tissues are different in subjects with PTSD as compared to subjects who do not suffer from this disorder. 1. A panel for determining the probability of the presence or absence of posttraumatic stress disorder (PTSD) in a subject wherein said panel containsdetection reagents for at least two microRNA selected from the group consisting of hsa-let-7a, hsa-let-7a*, hsa-miR-16, hsa-miR-33b, hsa-miR-146a, hsa-miR-185, hsa-miR-185*, hsa-miR-188-5p, hsa-miR-188-3p, hsa-miR-210, hsa-miR-505, hsa-miR-551, hsa-miR-598 and hsa-miR-663; and/ordetection reagents for at least two mRNA selected from the group consisting of HGD, RGS18, ND1, NT5C3, IGF2BP3, NEXN, HEXM2, DAPP1, SAV1, ID4, CXCR5, HS3ST1, CD72, TLR10, BANK1, MS4A1, FCRLA, CD79B, PPAPDC1B, TLC1A, KCNG1, FCRL1, FCRL2, BCOR, TC2N, LYPLAL1, RPA1, HMBOX1, RAMP1, FCGR1B, ADM, PRDM1, B4GALT5, MXRA7, TXNDC5, IGJ and LOC729451; and/ordetection reagents for at least two proteins selected from the group consisting of ANK2, AP3B2, APLP1, ANK3, APOD, BCAS1, BSN, CADM3, CAMK2A, CNP, CACNA1B, CLSTN1, CNTN1, CNTN2, CRH, CTNNA2, DCLK1, DDN, DOCK3, DPP10, EFNB3, ELAVL3, ENC1, EPHA5, FSD1, FOXG1, GBP3, GDAP1L1, gfap, GNAO1, GRIA1, GRIA2, GRIA3, GRIN1, GRM7, HIVEP2, JMY2, KCNC1, KIF1B, KIF3A, KIF5C, L1CAM, LGI1, LRRTM4, MAG, map, MAP1B, MAP3K12, MBP, MBP1, MYO16, NAP1L5, NCAM1, NCAM2, NCAN, NRXN3, OLFM1, OLFM3, PCDHA5, PCDHGA5, PCLO, PCSK2, PEA15, PKA1B, PRKAR1B, PSD2, PTPRD, RASGRF1, RGS4, RPH3A, SCG3, SLC4A10, SNAP25, SPTBN4, SST, STMN2, SYN1, SYNE1, SYT3, TAGLN3, UCHL1, WNT10B, ACTC1, ATP1A2, TNNI3K, CLDN18, IL8, CD117, A1BG, CFHR1, CRP, SCGB1A1, TSPAN19, NR0B2, HGFAC, FGA, UGT1A10, and NPHS2.2. The panel of wherein said at least one detection reagent is for ...
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