01-10-2015 дата публикации
Номер: US20150274799A1
Provided is a GLP-1 analogue having the structure as shown in the general formula A: 11. A GLP- analogue having the following general formula A:{'br': None, 'sup': 7', '37, 'sub': 10', '15', '22', '30', '33', '1', '1', '2', '2, 'HAEXTFTSXV SSYLE XQAAK EFIXW LXKGR GnXC nX\u2003\u2003General Formula A,'}{'sub': 10', '15', '22', '30', '33', '10', '15', '22', '30', '33, 'wherein Xis glycine or cysteine, Xis aspartic acid or cysteine, Xis glycine or cysteine, Xis alanine or cysteine, Xis valine or cysteine, and at least one of X, X, X, Xand Xis cysteine;'}{'sub': 1', '1', '1', '1', '1', '1, 'nXmeans that the number of Xis n, n=1-30, and Xis glycine, alanine or valine;'}{'sub': 2', '2', '2', '2', '2', '2, 'nXmeans that the number of Xis n, n=0-30, and Xis glycine, alanine or valine; and both of the two cysteines contained in the general formula A form disulfide bonds.'}3. The GLP-1 analogue as claimed in claim 1 , characterized in that the GLP-1 analogue has the following general formula II:{'br': None, 'sup': 7', '37, 'sub': 1', '1', '2', '2, 'HAEGT FTSCV SSYLE GQAAK EFIAW LVKGR GnXC nX\u2003\u2003General Formula II,'}{'sub': 1', '2', '1', '2, 'n=1-20, n=0-25, and wherein Xis glycine, alanine or valine, Xis glycine, alanine or valine;'}{'sub': 1', '2, 'preferably, n=3-20, n=3-25;'}{'sub': 1', '2, 'further preferably, said n=5-15, n=3-9.'}51. The GLP- analogue as claimed in claim 1 , characterized in that the GLP-1 analogue has the following general formula III:{'br': None, 'sup': 7', '37, 'sub': 1', '1', '2', '2, 'HAEGT FTSCV SSYLE GQAAK EFIAW LVKGR GnXC nX\u2003\u2003General Formula II,'}{'sub': 1', '2', '1', '2', '1', '2, 'wherein n=1-10, n=0-25, Xis glycine, alanine or valine, Xis glycine, alanine or valine; preferably, n=3-10, n=3-25;'}{'sub': 1', '2, 'or, n=1-5, n=10-20;'}{'sub': 1', '2, 'further preferably, n=3-5, n=10-20.'}7. The GLP-1 analogue as claimed in claim 1 , characterized in that the GLP-1 analogue has the following general formula IV:{'br': None, 'sup': ...
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