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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 142. Отображено 142.
10-12-2019 дата публикации

Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof

Номер: US0010501550B2

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

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06-02-2008 дата публикации

Adriablastina antineoplastic medicine and gland correlated virus composite preparations and uses thereof

Номер: CN0101116748A
Принадлежит:

The invention belongs to the biologic medicine filed and relates to a novel gene therapy compound preparation and the use and application method thereof. When adeno-associated virus is used as gene delivery carrier, a certain dose of adriamycin is combined in use, and obviously advances expression time of foreign gene mediated by adeno-associated virus, obviously increases the transfer efficiency and gene expression level, and prolongs expression time. The experiment result indicates that the compound preparation does not have obvious toxic and side effects on cells. The compound preparation and application method thereof can be used in instructing and assisting gene therapy for ophthalmopathy, genetic disease and tumor.

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27-08-2021 дата публикации

Embedded skylight structure with drainage function

Номер: CN214062149U
Автор: LI HUIMING, 李辉明
Принадлежит: LI HUIMING, 李辉明

The embodiment of the utility model discloses an embedded skylight structure with a drainage function, which comprises a frame section bar and a sash section bar which are mutually closed, sound insulation and heat insulation glass is arranged in the sash section bar, one side of the frame section bar is hinged to one side of the sash section bar, the frame section bar and the sash section bar are provided with outer edges which are matched in a concave-convex mode, and the sash section bar is provided with an inner section bar frame. An outer profile frame extending outwards is arranged on the inner profile frame, a structure cavity is formed by the inner profile frame and the inner side face of the outer profile frame, the sound insulation and heat insulation glass is arranged at the position of the structure cavity, the frame profile is provided with an installation frame, a hook piece is arranged on the outer edge of the installation frame, a groove is formed in the bottom of the installation ...

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02-06-2010 дата публикации

Improved cuprammonium (amine) quaternary ammonium salt antiseptics for wood

Номер: CN0101279456B
Принадлежит:

The invention discloses an improved copper ammonia doped quaternary ammonium salt wood preservative, which is characterized in that the copper ammonia doped quaternary ammonium salt wood preservativecontains 1, 3, 5-trimethylol sym-triazine. The improved copper ammonia doped quaternary ammonium salt wood preservative of the invention has better anti-mold effects and causes fewer metallic corrosions than the non-improved-modified ACQ wood preservatives does, thereby widening the application range of the ACQ wood preservatives.

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11-05-2011 дата публикации

Three-phase amorphous alloy isolation transformer

Номер: CN0102054573A
Принадлежит:

The invention relates to a three-phase amorphous alloy isolation transformer which comprises an iron core, an inner winding and an outer winding, wherein the iron core is a four-frame and five-column iron core formed by winding amorphous alloy, a metal isolating layer is arranged between the inner winding and the outer winding, the outer side of an iron yoke of the iron core is provided with a hard combined insulation member, the upper end and the lower end of the hard combined insulation member are respectively connected with an upper padding plate and a lower padding plate, cushion blocks are arranged between the windings and the upper padding plate and between the windings and the lower padding plate, the other end of the hard combined insulation member is provided with an upper clamping member, the other end of the lower padding plate is provided with a lower clamping member, and a locator is arranged on the lower end face of the lower clamping member. A metal foil is used as the metal ...

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29-11-2018 дата публикации

ANTIBODIES AGAINST GLUCOCORTICOID-INDUCED TUMOR NECROSIS FACTOR RECEPTOR (GITR) AND USES THEREOF

Номер: US20180339042A1
Принадлежит:

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies. 1. An isolated antibody , or antigen binding fragment thereof , that binds to human glucocorticoid-inducible TNF receptor (GITR) and comprises a heavy chain constant region comprising (1) an amino acid sequence selected from the group consisting of SEQ ID NOs: 223-226 , 283-290 , 383-446 and 480-543 or (2) a heavy chain constant region that differs therefrom in at most 5 amino acids or is at least 95% , 96% , 97% , 98% or 99% identical to an amino acid sequence of SEQ ID NOs: 223-226 , 283-290 , 383-446 and 480-543 , wherein the amino acid modification(s) are not at the specific amino acid(s) in SEQ ID NOs: 223-226 , 283-290 , 383-446 and 480-543 that are not present in the naturally-occurring human heavy chain constant regions.2. The antibody claim 1 , or antigen binding portion thereof claim 1 , of claim 1 , wherein the antibody stimulates an anti-tumor immune response.3. The antibody claim 1 , or antigen binding portion thereof claim 1 , of or claim 1 , wherein the antibody stimulates an antigen-specific T cell response.4. The antibody claim 1 , or antigen binding portion thereof claim 1 , of any one of the preceding claims claim 1 , wherein the antibody increases IL-2 and/or IFN-γ production in GITR-expressing T cells.5. The antibody claim 1 , or antigen binding portion thereof claim 1 , of any one of the preceding claims claim 1 , wherein the antibody increases T cell proliferation.6. The antibody claim 1 , or antigen binding portion thereof claim 1 , of any one of the ...

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10-12-2015 дата публикации

ANTIBODIES AGAINST GLUCOCORTICOID-INDUCED TUMOR NECROSIS FACTOR RECEPTOR (GITR) AND USES THEREOF

Номер: CA0002951234A1
Принадлежит: Bristol Myers Squibb Co

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid- inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

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08-12-2016 дата публикации

ANTI-GITR ANTIBODIES FOR CANCER DIAGNOSTICS

Номер: CA0002988115A1
Принадлежит:

Provided herein are diagnostic antibodies that bind to glucocorticoid-induced tumor necrosis factor receptor (GITR). Such antibodies are useful for methods of detecting the expression of GITR in biological samples, for example, tumor tissue, and identifying a cancer patient likely to respond to anti-GITR immunotherapy or predicting whether a cancer patient will respond to anti-GITR immunotherapy.

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26-05-2017 дата публикации

ANTIBODIES AGAINST GLUCOCORTICOID-INDUCED TUMOR NECROSIS FACTOR RECEPTOR (GITR) AND USES THEREOF

Номер: CA0003005855A1
Принадлежит:

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

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05-11-2014 дата публикации

Automatic cannonball painting device

Номер: CN104128279A
Принадлежит:

The invention belongs to the technical field of intersections of ammunition engineering and environmental protection, and relates to an automatic cannonball painting device. A painting chamber is of a sealed three-dimensional frame structure welded by steel tubes, an inlet and an outlet of the painting chamber are profiling door openings, and a smooth water flowing plate is arranged on the inner wall of one side of the painting chamber. A circulating water system comprises a circulating pool, a water pump and a drainage tube, the circulating pool is installed at the bottom of the painting chamber, the water pump is installed in the circulating pool, and the drainage tube is connected to the bottom of the circulating pool. A paint fog trapping device comprises an air exhaust channel, waved plates and a water dropping plate, the multiple waved plates which are slant and uncrossed are arranged in the air exhaust channel, and the water dropping plate is arranged on the side, adjacent to the ...

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08-12-2016 дата публикации

Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof

Номер: AU2015271709A1
Принадлежит: AJ PARK

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid- inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

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21-02-2019 дата публикации

Antibodies against TIM3 and uses thereof

Номер: AU2017297506A1
Принадлежит: AJ PARK

Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

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18-01-2018 дата публикации

ANTIBODIES AGAINST TIM3 AND USES THEREOF

Номер: CA0003030765A1
Принадлежит:

Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

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26-11-2020 дата публикации

Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof

Номер: AU2015271709B2
Принадлежит: AJ PARK

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid- inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

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25-08-2010 дата публикации

Method and system for third party to real-time monitor remote control process

Номер: CN0101291426B
Принадлежит:

The invention relates to a remote monitoring technique, in particular to a method and a system for realizing a third-party real-time monitoring remote control process, which can carry out third-party monitoring to a control end and a controlled end in a remote monitoring process. The method comprises the following steps that: the connection between the controlled end and a third-party monitoring end is established; based on the connection, the control end, the controlled end and the third-party monitoring end are in the same conversation; the controlled end sends the desktop video thereof to the third-party monitoring end through a virtual display driver; the third-party monitoring end sends preset control strategy to the controlled end.

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25-05-2017 дата публикации

ANTIBODIES AGAINST GLUCOCORTICOID-INDUCED TUMOR NECROSIS FACTOR RECEPTOR (GITR) AND USES THEREOF

Номер: US20170145104A1
Принадлежит:

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies. 168-. (canceled)69. An isolated antibody which binds to human glucocorticoid-inducible TNF receptor (GITR) , comprising:(a) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 20, 21, and 22, respectively, and light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 23, 24, and 25, respectively;(b) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 33, 34, and 35, respectively, and light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 36, 37, and 38, respectively;(c) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 46, 47, and 48, respectively, and light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 49, 50, and 51, respectively;(d) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 62, 63, and 64, respectively, and light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 65, 66, and 67, respectively;(e) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 62, 63, and 64, respectively, and light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 68, 69, and 70, respectively;(f) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 78, 79, and 80, respectively, and light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 81, 82, and 83, respectively;(g) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 91, 92, and 93, respectively, and light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 94, 95, and 96, ...

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12-05-2023 дата публикации

Base station energy saving method and device and computer readable storage medium

Номер: CN116113022A
Принадлежит:

The invention provides a base station energy saving method and device and a computer readable storage medium, relates to the field of communication, and can save the energy consumption of a base station on the basis of not influencing the user experience. The method comprises the following steps: determining a target index set of each target 4G base station in a plurality of target 4G base stations of a fourth generation mobile communication network; the target 4G base station is located in the coverage range of the target 5G base station, the position of the target 4G base station is not provided with the 5G base station, and the position of the target 5G base station is not provided with the 4G base station; determining an entropy value and a weight of each target index in each target index set; generating a target index of each target index set, and moving the target 4G base station corresponding to the target index with the maximum value to the target 5G base station; one target index ...

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10-08-2021 дата публикации

Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof

Номер: US0011084881B2

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

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28-06-2018 дата публикации

Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof

Номер: AU2016356780A1
Принадлежит: AJ PARK

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

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05-01-2016 дата публикации

Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof

Номер: US0009228016B2

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

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23-05-2023 дата публикации

Edge-end data interaction method for distributed resource regulation and control

Номер: CN116155718A
Принадлежит:

The invention provides an edge-end data interaction method for distributed resource regulation and control. The method comprises the following steps: formulating an information interaction model between an edge node and terminal equipment; formulating an equipment registration and conventional information interaction system between the edge node and the terminal equipment, wherein the equipment registration and conventional information interaction system is in the equipment registration and conventional information interaction system; formulating a communication management interface model between the edge node and the terminal equipment; the communication module based on a plug-and-play working mode forms a plug-and-play interaction mode between the edge node and the terminal equipment; and carrying out edge-end data interaction by adopting a plug-and-play interaction mode between the edge node and the terminal equipment, which is formulated and formed in the previous steps. According to ...

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16-05-2023 дата публикации

Circuit breaker opening and closing electromagnet driving performance evaluation method, system and equipment

Номер: CN116125267A
Принадлежит:

The invention relates to the technical field of circuit breaker opening and closing electromagnet detection, in particular to a circuit breaker opening and closing electromagnet driving performance evaluation method, system and device, and the method comprises the steps: determining a control voltage parameter; the control voltage parameters at least comprise control voltage magnitude and control voltage output duration; determining a gap distance between the to-be-evaluated opening and closing electromagnet and the driving force sensor; electrifying the to-be-evaluated opening and closing electromagnet based on the control voltage parameter so as to drive an armature of the to-be-evaluated opening and closing electromagnet to move to impact a driving force sensor; receiving a driving force actual value acquired by a driving force sensor; obtaining a driving force standard value of the opening and closing electromagnet under the conditions of the control voltage parameter and the gap distance ...

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09-05-2023 дата публикации

Application of phenethyl alcohol in aspect of inducing plant resistance

Номер: CN116076261A
Принадлежит:

The invention provides application of phenethyl alcohol in the aspect of inducing plant resistance. The model plant arabidopsis thaliana is taken as a test material, and the obvious resistance to the colletotrichum gloeosporioides of the arabidopsis thaliana can be generated after the induction of low-concentration phenethyl alcohol, and the disease condition of the colletotrichum gloeosporioides is The analysis on hormone and transcriptome in arabidopsis thaliana shows that phenethyl alcohol has a positive effect on the aspect of inducing the disease resistance of model plant arabidopsis thaliana, and is an effective plant source resistance inducer.

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03-12-2014 дата публикации

New organic-solvent preservative, its preparation and application

Номер: CN0102273482B
Принадлежит:

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10-09-2008 дата публикации

Wood fire retardant and wood veneer flame-proof processing technique

Номер: CN0101259629A
Принадлежит:

The invention discloses a wood fire retardant which is characterized in that the wood fire retardant consists of the following components in weight percentage: 8 to 12 percent of borax, 8 to 12 percent of boric acid, 8 to 12 percent of cyanogen, 33 to 38 percent of ammonium phosphate, and 33 to 38 percent of ammonium sulfate. The wood fire retardant of the invention can be simply prepared, can offer flame retardancy to wood and can meet requirements for various national standards; the fire retardant property of the wood board which is processed by the board flame retardant of the invention can meet requirements for various national standards; after the fireproof plywood of the invention is subject to the use of the fire retardant of the invention, goes through the veneer processing and then is glue-pressed into complete boards, the flame retardant property of the fireproof plywood is superior to the plywood which is first glud-pressed and then goes through the complete board fame retardant ...

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08-10-2008 дата публикации

Improved cuprammonium (amine) quaternary ammonium salt antiseptics for wood

Номер: CN0101279456A
Принадлежит:

The invention discloses an improved copper ammonia doped quaternary ammonium salt wood preservative, which is characterized in that the copper ammonia doped quaternary ammonium salt wood preservative contains 1, 3, 5-trimethylol sym-triazine. The improved copper ammonia doped quaternary ammonium salt wood preservative of the invention has better anti-mold effects and causes fewer metallic corrosions than the non-improved-modified ACQ wood preservatives does, thereby widening the application range of the ACQ wood preservatives.

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10-12-2014 дата публикации

Matting without warps and processing technology thereof

Номер: CN104188438A
Автор: LI HUIMING
Принадлежит:

The invention relates to a kind of matting without warps. The matting comprises a matting body. Bamboo battens are used as the wefts of the matting, and the adhesive tape is used for replacing warps to bond the bamboo battens so that the matting body can be formed. The adhesive tape is composed of base materials and adhesive. The adhesive is prepared from, by weight, 10 parts to 20 parts of modified SBS resin, 15 parts to 40 parts of tackifying resin, 50 parts to 100 parts of solvent, 1 part to 3 parts of plasticizer, 5 parts to 8 parts of filler, 0.5 part to 1 part of anti-aging agent and 0.5 part to 1 part of antioxidant. According to the processing technology of the matting, first, the bamboo battens are used as the wefts, the bamboo battens are hot-pressed together with the adhesive tape at the temperature from 30 DEG C to 60 DEG C under the pressure from 2 MPa to 6 MPa, and the matting body is obtained; then, the fracture surface of the matting body is wrapped with edge lining cloth ...

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07-04-2010 дата публикации

Benzo or naphtha isoxazolidine derivatives and synthesis method thereof

Номер: CN0101691378A
Принадлежит:

The invention relates to benzo or naphtha isoxazolidine derivatives and a synthesis method thereof. The compounds have a structure as follows, wherein X is -OCH3,-CH3, -H,-Cl or -NO2. The method comprises: taking benzo bis(oxygen disilicon cyclopentadienyl) or oxygen disilicon-based naphthalene as a benzyne or naphthalyne precursor; generating benzyne or naphthalyne under mild conditions; allowing the benzyne or naphthalyne to further react with nitrone; and generating oxygen disilicon-based benzo isoxazolidine derivatives or naphtha isoxazolidine derivatives. The invention has the advantages of high reaction speed, mild reaction conditions, high yield, simple method and the like, provides an effective way for constructing benzo or naphtha isoxazolidine skeletons, and enriches the synthesis method of organic heterocyclic compounds.

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20-01-2016 дата публикации

Special waist belt of resource investigation

Номер: CN0204969621U
Автор: LI HUIMING
Принадлежит:

The utility model belongs to resource investigation equips the field, concretely relates to special waist belt of resource investigation, including the area body and toolbox, the area body passes through the fixture block with the toolbox to be connected, and area body middle part is equipped with the telescopic band, is equipped with pressure sensor and controller on the telescopic band, takes external side to be equipped with the slide, and the slide both ends are equipped with first embedded groove and second embedded groove, the toolbox top be equipped with small tool jack, big instrument jack, handle and toolbox apron, the toolbox right side is equipped with the fixture block, the toolbox left side is equipped with the couple, the embedded groove be connected with the fixture block, the fixture block be the T type, and the right -hand member of fixture block is the same with the embedded groove size, the width of width ratio embedded groove of slide little, the utility model has the ...

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04-08-2023 дата публикации

Gas drive leading edge monitoring method and system

Номер: CN116537762A
Принадлежит:

The invention discloses a gas drive front edge monitoring method and system.The gas drive front edge monitoring method is applied to a horizontal well or a highly-deviated well and comprises the steps that S1, field construction is prepared; and S2, performing on-site exploration, and making an obvious protection mark on a measuring point. And S3, debugging the field equipment. And S4, laying a measuring line along the ground projection of the perforation well section, and carrying out a gas injection test. And S5, obtaining and storing test data, and completing monitoring. And step S6, preprocessing and editing the test data. Therefore, the gas drive front edge monitoring method provided by the invention provides effective support and basis for reasonably regulating and controlling a well opening and closing system and process measures.

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14-11-2018 дата публикации

ANTIBODIES AGAINST TIM3 AND USES THEREOF

Номер: AR0000109262A1
Принадлежит: Bristol Myers Squibb Co

Anticuerpos, o porciones de fijación al antígeno de estos, que se fijan a la proteína 3 que contiene el dominio de mucina e inmunoglobulina de linfocitos T (TIM3). Reivindicación 13: El anticuerpo, o la porción de fijación al antígeno de este, de acuerdo con cualquiera de las reivindicaciones anteriores, caracterizado porque el anticuerpo, o la porción de fijación al antígeno de este, comprende CDR1, CDR2 y CDR3 de la cadena pesada y CDR1, CDR2 y CDR3 de la cadena liviana, en donde CDR3 de la cadena pesada comprende una secuencia de aminoácidos seleccionada del grupo que consiste en: SEQ ID Nº 53, SEQ ID Nº 54, SEQ ID Nº 55, SEQ ID Nº 56, SEQ ID Nº 57, SEQ ID Nº 58, SEQ ID Nº 59, SEQ ID Nº 126, SEQ ID Nº 127, SEQ ID Nº 128 o SEQ ID Nº 129.

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19-08-2015 дата публикации

Measuring device

Номер: CN104841703A
Принадлежит:

A measuring device is used for measuring the thickness of a steel plate on line. The measuring device comprises a support, an ultrasonic wave emitting source, an ultrasonic wave receiving source and a calculation processing device, the device is connected with the ultrasonic wave emitting source and the ultrasonic wave receiving source through data lines respectively and can calculate the thickness of a steel plate according to the relative positions and X-ray angles of the ultrasonic wave emitting source and the ultrasonic wave receiving source; the measuring device comprises a post-processing cooling device which can cool the steel plate directly according to a measurement result. The measuring device is high in accuracy, convenient, rapid, low in energy consumption of the cooling device and good in scale removal effect.

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30-05-2023 дата публикации

Cloud side-end collaborative management and control system based on electric power Internet of Things

Номер: CN116192601A
Принадлежит:

The invention relates to the technical field of cloud side end cooperation of the Internet of Things, and discloses a cloud side end cooperation management and control system based on the electric power Internet of Things. The system comprises an acquisition layer, a network layer and an application layer, the acquisition layer is used for acquiring related power data of each edge node in real time; the network layer comprises an MQTT protocol module and a public information model management module; the MQTT protocol module is used for realizing information release and subscription between the cloud platform and the edge node; the public information model management module is used for managing related power data through a planning database based on a CIM modeling idea; the application layer comprises a cloud platform; and the cloud platform is used for carrying out real-time online monitoring on the related power data, forming a detection report and providing a detection report interface ...

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18-10-2018 дата публикации

ANTIBODIES AGAINST TIM3 AND USES THEREOF

Номер: US20180298097A1
Принадлежит: Bristol-Myers Squibb Company

Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof. 1. An isolated antibody (e.g. , a human antibody) , or antigen binding portion thereof , which binds to human T-cell immunoglobulin and mucin-domain containing-3 (TIM3) and exhibits the following properties:(a) binds to soluble human TIM3;(b) binds to membrane bound human TIM3;(c) induces or enhances T cell activation; and optionally;(d) binds to soluble cynomolgus TIM3; and(e) binds to membrane cynomolgus TIM3.2. The antibody claim 1 , or antigen binding portion thereof claim 1 , of claim 1 , wherein the antibody stimulates an anti-tumor immune response.3. The antibody claim 1 , or antigen binding portion thereof claim 1 , of or claim 1 , wherein the antibody stimulates an antigen-specific T cell response.4. The antibody claim 1 , or antigen binding portion thereof claim 1 , of any one of the preceding claims claim 1 , wherein the antibody increases IFN-γ production in TIM3-expressing T cells.5. The antibody claim 1 , or antigen binding portion thereof claim 1 , of any one of the preceding claims claim 1 , wherein the antibody increases T cell proliferation.6. The antibody claim 1 , or antigen binding portion thereof claim 1 , of any one of the preceding claims claim 1 , wherein the antibody does not bind to Fc receptors claim 1 , or wherein the antibody lacks effector function.7. The antibody claim 1 , or antigen binding portion ...

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20-08-2014 дата публикации

Novel crude fiber healthcare moon cake and production method thereof

Номер: CN103988869A
Принадлежит:

The invention provides a novel crude fiber healthcare moon cake. The novel crude fiber healthcare moon cake comprises a stuffing core. A crisping layer is wrapped outside the stuffing core. A tough layer is wrapped outside the crisping layer. A surface skin layer is wrapped outside the tough layer. An egged layer is wrapped outside the surface skin layer. The novel crude fiber healthcare moon cake has the advantages of being unique in taste, rich in nutrition and the like; the moon cake is of a multilayered structure and has distinct layers, the surface skin is soft and chewy, the intermediate layers are crisp in taste, and the stuffing core is tender and not greasy; the crisping layer is made in the mode that rice bran and corn flour are subjected to solid-state fermentation and mixed with flour after indigestible fibers in the rice bran and the corn flour are decomposed into amino acid, so the novel crude fiber healthcare moon cake is rich in nutrient elements which are essential for ...

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20-01-2016 дата публикации

Special umbrella of resource investigation

Номер: CN0204969865U
Автор: LI HUIMING
Принадлежит:

The utility model belongs to resource investigation equips the field, concretely relates to special umbrella of resource investigation, including umbrella face, umbrella stick and rib, the umbrella stick upper end is connected with the center of rib, and the rib stitches on the umbrella face, and the rib upper end is equipped with the phosphor strip, is equipped with solar cell panel and slide on the umbrella face, is equipped with the couple on the slide, and the umbrella stick lower extreme is connected with the rib, is equipped with intercom, USB interface and controller on the rib, and the controller is connected with intercom, USB interface and solar cell panel respectively, solar cell panel pass through the umbrella stick and be connected with the controller, the controller on be equipped with microprocessor, the utility model has the advantages of simple structure, reasonable in design, safe and reliable, convenient to use, elegant appearance, low cost can on a large scale promote ...

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15-08-2019 дата публикации

ANTIBODIES AGAINST TIM3 AND USES THEREOF

Номер: US20190248893A1
Принадлежит: Bristol-Myers Squibb Company

Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof. 1. An isolated antibody (e.g. , a human antibody) , or antigen binding portion thereof , which binds to human T-cell immunoglobulin and mucin-domain containing-3 (TIM3) and exhibits the following properties:(a) binds to soluble human TIM3;(b) binds to membrane bound human TIM3;(c) induces or enhances T cell activation; and optionally:(d) binds to soluble cynomolgus TIM3; and(e) binds to membrane cynomolgus TIM3.2. The antibody claim 1 , or antigen binding portion thereof claim 1 , of claim 1 , wherein the antibody stimulates an anti-tumor immune response.3. The antibody claim 1 , or antigen binding portion thereof claim 1 , of or claim 1 , wherein the antibody stimulates an antigen-specific T cell response.4. The antibody claim 1 , or antigen binding portion thereof claim 1 , of any one of the preceding claims claim 1 , wherein the antibody increases IFN-γ production in TIM3-expressing T cells.5. The antibody claim 1 , or antigen binding portion thereof claim 1 , of any one of the preceding claims claim 1 , wherein the antibody increases T cell proliferation.6. The antibody claim 1 , or antigen binding portion thereof claim 1 , of any one of the preceding claims claim 1 , wherein the antibody does not bind to Fc receptors claim 1 , or wherein the antibody lacks effector function.7. The antibody claim 1 , or antigen binding portion ...

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06-06-2014 дата публикации

Vehiculo

Номер: CL2013002016S1
Принадлежит:

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18-09-2018 дата публикации

Antibodies against TIM3 and uses thereof

Номер: US0010077306B2

Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

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14-01-2015 дата публикации

Multifunctional health care pillow for infants

Номер: CN104274006A
Автор: LI HUIMING
Принадлежит:

The invention relates to a multifunctional health care pillow for infants. The multifunctional health care pillow for the infants comprises a pillowcase and a pillow interior. The pillow interior comprises a heat-preserving layer and a filling bag, and the filling bag is filled with Chinese herbal medicine filler composed of, by weight, 1-8% of bamboo charcoal, 1-8% of arabian jasmine flowers, 50-70% of negundo chastetree fruits and 20-40% of cassia seeds. According to a preparation method of the multifunctional health care pillow for the infants, the bamboo charcoal is smashed and wrapped by cotton cloth to form a charcoal bag, the cassia seeds, the arabian jasmine flowers and the negundo chastetree fruits are screened, cleaned, dried and disinfected and then mixed with the charcoal bag uniformly according to the proportion of the filler, then the mixture is placed into the filling bag, the bag opening is sewn, the filling bag is placed in the depression of the heat-preserving layer and ...

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05-12-2007 дата публикации

Circular disc type triangular float-valve

Номер: CN0101081336A
Принадлежит:

The present invention discloses one kind of circular float valve, which consists of one circular valve plate, one small triangular valve plate and a valve leg. Setting the small triangular valve plate onto the circular valve plate can increase the effective area of the gas channel, homogenize the gas distribution, lower the gas flow rate, raise the treating capacity, reduce entrained foams, reduce liquid surface gradient and the pressure drop of the column plate a raise mass transferring effect. The present invention may be applied widely in gas-liquid mass transferring columns.

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16-04-2020 дата публикации

ANTIBODIES AGAINST GLUCOCORTICOID-INDUCED TUMOR NECROSIS FACTOR RECEPTOR (GITR) AND USES THEREOF

Номер: US20200115463A1
Принадлежит:

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies. 168-. (canceled)69. An isolated antibody which binds to glucocorticoid-inducible TNF receptor (GITR) , comprising:(a) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 20, 21, and 22, respectively, and light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 23, 24, and 25, respectively;(b) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 33, 34, and 35, respectively, and light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 36, 37, and 38, respectively;(c) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 46, 47, and 48, respectively, and light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 49, 50, and 51, respectively;(d) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 62, 63, and 64, respectively, and light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 65, 66, and 67, respectively;(e) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 62, 63, and 64, respectively, and light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 68, 69, and 70, respectively;(f) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 78, 79, and 80, respectively, and light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 81, 82, and 83, respectively;(g) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 91, 92, and 93, respectively, and light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 94, 95, and 96, ...

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26-08-2015 дата публикации

Link detection method and access equipment

Номер: CN104869027A
Принадлежит:

The invention discloses a link detection method and access equipment. The method comprises the steps that A) whether the access equipment is registered in the IMS core network is detected, if no, a step B) is turned to, and otherwise, a step E) is turned to; B) a link detection message with a preset domain name is sent; C) whether a response message is received is detected, if no, the step B) is turned to, and otherwise, a step D) is turned to; D) SBC identification information by inquiring the preset domain name is obtained and stored, and a step I) is carried out; E) if SBC identification information of the highest priority is not read, the step B) is carried out, and if SBC identification information of the highest priority is read, a step F) is turned to; F) a link detection message with identification information is sent; G) whether a response message is received is detected, if yes, the step I) is carried out, and otherwise, a step H ) is carried out; H) SBC identification information ...

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04-03-2015 дата публикации

Health care mat and manufacturing process thereof

Номер: CN104382429A
Автор: LI HUIMING
Принадлежит:

The invention relates to a health care mat. The health care mat comprises a mat body and a carbon cloth layer arranged on the lower surface of the mat body; the carbon cloth layer comprises a carbon cloth base body and non-woven fabrics arranged on the upper surface and/or the lower surface of the carbon cloth base body; health care components formed by mixing Chinese herbal medicines and natural rubber cement according to the weight ratio of (10-30):100 are sprayed to the surface of the carbon cloth base body; and the using amount of the health care components is 200-230 g/m<2>. The manufacturing process of the health care mat includes the steps of firstly selecting one of a straw mat, a rattan mat, a bamboo mat and a meryl mat to serve as a mat body; then taking the Chinese herbal medicines to be dried and smashed; evenly mixing the Chinese herbal medicines and the natural rubber cement in proportion to spray a mixture of the Chinese herbal medicines and the natural rubber cement to the ...

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23-09-2009 дата публикации

Copper azole wood protective agent

Номер: CN0100542759C
Принадлежит:

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19-01-2005 дата публикации

Neurofender, the novel formulation of preventing and delaying aging and death of human cerebral neurocyte

Номер: CN0001565452A
Автор: LI HUIMING, LI LI, HUIMING LI
Принадлежит:

The invention discloses a medicinal Neurofender comprising two pharmaceutical constituents of caffeine and P38 enzyme inhibitor, these preparations can reinforce nerve cell film electroactivity, increase LTP forming capability for cells, and lower RAP activation.

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28-04-2023 дата публикации

Foundation excavator for steel structure engineering construction

Номер: CN116025021A
Принадлежит:

The invention relates to the technical field of building construction, and discloses a foundation excavator for steel structure engineering construction, which comprises a support frame, an excavating mechanism and a support mechanism, the side, close to the ground, of the cross-shaped supporting frame is fixedly connected with a suspension frame, the middle of the suspension frame is rotationally connected with a first rotating sleeve coaxial with the lead screw, the side, away from the ground, of the first rotating sleeve is provided with a first driven gear, and the side, close to the ground, of the first rotating sleeve is slidably connected with a first telescopic rod. A transverse plate is arranged in the middle of the first telescopic rod, and a soil taking spiral head is arranged at the end of the first telescopic rod. According to the foundation excavator for steel structure engineering construction, the lead screw and the soil taking spiral head rotate separately through vertical ...

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18-06-2020 дата публикации

ANTIBODIES AGAINST TIM3 AND USES THEREOF

Номер: US20200190186A1
Принадлежит: Bristol-Myers Squibb Company

Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof. 124-. (canceled)25. An isolated antibody , which binds to a human TIM3 , comprising a heavy chain CDR1 , CDR2 , and CDR3 and a light chain CDR1 , CDR2 , and CDR3 , wherein:(a1) the heavy chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs: 41, 46, and 53, respectively, and the light chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs: 64, 66, and 68, respectively;(a2) the heavy chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs: 41, 122, and 53, respectively, and the light chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs: 64, 66, and 68, respectively;(a3) the heavy chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs: 41, 123, and 53, respectively, and the light chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs: 64, 66, and 68, respectively;(a4) the heavy chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs: 41, 124, and 53, respectively, and the light chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs: 64, 66, and 68, respectively;(a5) the heavy chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs: 41, 46, and 126, respectively, and the light chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs: 64, 66, and 68, respectively;(a6) the heavy chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs: 41, 46, and 127, respectively, and the light chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs: 64, 66, and 68, respectively;(a7) the heavy chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs: 41, 46, and ...

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04-08-1993 дата публикации

Preparation of colloidal antimony pentoxide by chlorination hydrolysis process

Номер: CN0001074945A
Принадлежит:

Various antimony-containing ore concentrate or other materials such as coarse antimonic oxide and the arsenic basic slag from antimony refining is used as raw materials. Through such technological steps as chlorination leaching with hydrochloric acid or FeCl3 (SbCl5), oxidation with chlorine or hydrogen peroxide, hydrolysis, filter, leaching, dispergation and concentration, a water-soluble sol or organic sol of colloidal Sb2O5 having low viscosity is obtained. After drying, a powdered Sb2O5 with 60-85% of purity is produced.

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20-08-2014 дата публикации

Low-calorie and high-nutrition baked food with health care function

Номер: CN103988863A
Принадлежит:

Low-calorie and high-nutrition baked food with the health care function is made of crude fiber food such as buckwheat powder, wheat bran, sweet potato powder, corn flour, wheat flour, skim milk powder, Konjac powder, nutrient enrichment components and the like, wherein the crude fiber food such as the buckwheat powder, the wheat bran, the sweet potato powder and the corn flour is fermented in advance through probiotics such as bifidobacteria, lactobacilli, bacillus subtilis and yeast powder. The low-calorie and high-nutrition baked food has the advantages of being rich in nutrition and low in content of saturated fatty acid and balancing diet, and the buckwheat powder, the wheat bran and the sweet potato powder are rich in cellulose and decomposed into small molecular weight organics through fermentation, which is beneficial for absorption of the human body; the buckwheat powder serves as a source of protein and is high in protein content and rich in various minerals, and rice bran oil ...

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20-08-2014 дата публикации

Biscuit food and continuous fermentation device thereof

Номер: CN103988870A
Принадлежит:

Disclosed are biscuit food and a continuous fermentation device of the biscuit food. According to the biscuit food, oat, wheat bran and pectin are fermented through a solid state continuous fermentation device, and then the oat, the wheat bran, the pectin, wheatmeal, high-temperature-resisting alpha-diastasum diastace, papain, nisin, soybean meal, food additives and the like are baked to form the biscuit food. The biscuit food has the advantages of being unique in taste, rich in nutrition and the like. The oat, the wheat bran and other raw materials are continuously fermented under the synergistic effect of bifidobacterium species, lactobacillus, bacillus subtilis, active acetic bacteria, fresh yeast and other floras, and the effective constituents are decomposed into small molecular weight organic compounds which are easily absorbed by the human body. The biscuit food overcomes defects of high oil, high sugar and high heat of a traditional biscuit, and has the advantages of resisting cancer ...

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21-07-2023 дата публикации

Method for measuring pretightening force of small-size bolt based on piezoelectric ultrasonic resonance method

Номер: CN116465537A
Принадлежит:

A small-size bolt pre-tightening force measuring method based on a piezoelectric ultrasonic resonance method comprises the following steps that S1, a bolt with the same specification and size as a to-be-measured bolt is selected as a calibration bolt, and an ultrasonic longitudinal wave transducer is arranged at the head of the calibration bolt; s2, performing a pre-tightening force calibration experiment on the calibration bolt by using a high-energy ultrasonic test system to obtain ultrasonic resonance frequency shift under different pre-tightening forces; s3, obtaining a function relationship between the bolt pre-tightening force and the ultrasonic resonance frequency shift amount through linear fitting; s4, arranging an ultrasonic longitudinal wave transducer at the bolt head of the to-be-tested bolt, and after the to-be-tested bolt is tightened, performing ultrasonic resonance frequency sweep excitation on the to-be-tested bolt by adopting a high-energy ultrasonic testing system to ...

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27-01-2016 дата публикации

Radio signal ensures device

Номер: CN0205005050U
Принадлежит:

The utility model provides a radio signal ensures device relates to wireless signal communication and thing networking field. This radio signal ensures device includes: the antenna, with antenna connection's amplifier circuit and with the communicator that amplifier circuit connects, antenna receive base stations's down signal warp after amplifier circuit enlargies, through the communicator sends to the acquisition terminal, the communicator is received the signal that goes upward of gathering terminal acquisition and is passed through after amplifier circuit enlargies, through the antenna sends to the basic station. The utility model discloses a radio signal ensures device can effectively improve the collection terminal equipment's that checks meter signal, solves the problem that radio signal is not enough, and the lower simple to operate of cost.

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04-05-2011 дата публикации

Wood fire retardant and wood veneer flame-proof processing technique

Номер: CN0101259629B
Принадлежит:

The invention discloses a wood fire retardant which is characterized in that the wood fire retardant consists of the following components in weight percentage: 8 to 12 percent of borax, 8 to 12 percent of boric acid, 8 to 12 percent of cyanogen, 33 to 38 percent of ammonium phosphate, and 33 to 38 percent of ammonium sulfate. The wood fire retardant of the invention can be simply prepared, can offer flame retardancy to wood and can meet requirements for various national standards; the fire retardant property of the wood board which is processed by the board flame retardant of the invention can meet requirements for various national standards; after the fireproof plywood of the invention is subject to the use of the fire retardant of the invention, goes through the veneer processing and then is glue-pressed into complete boards, the flame retardant property of the fireproof plywood is superior to the plywood which is first glud-pressed and then goes through the complete board fame retardant ...

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01-08-2023 дата публикации

Efficient scale inhibitor as well as preparation method and application thereof

Номер: CN116514294A
Принадлежит:

The invention provides an efficient scale inhibitor as well as a preparation method and application thereof, and relates to the technical field of sewage treatment. The efficient scale inhibitor provided by the invention is prepared from the following preparation raw materials in parts by weight: 15 to 20 parts of polyaspartic acid, 20 to 30 parts of sodium polyepoxysuccinate, 2 to 5 parts of sodium polyacrylate, 3 to 5 parts of hydrolytic polymaleic anhydride, 3 to 5 parts of etidronic acid, 5 to 12 parts of citric acid, 1 to 3 parts of nonionic emulsifier, 5 to 10 parts of isothiazolinone and 10 to 46 parts of demineralized water. The preparation raw materials are good in synergism and stable in performance under a proper ratio, and the scale inhibitor has the advantages of high scale inhibition efficiency, excellent corrosion and scale inhibition capability and remarkable biological slime stripping effect when being used for treating a high-hardness, high-salt and high-alkalinity landfill ...

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28-12-2018 дата публикации

ANTIBODIES AGAINST GLUCOCORTICOID-INDUCED TUMOR NECROSIS FACTOR RECEPTOR (GITR) AND USES THEREOF

Номер: SG10201810507WA
Принадлежит:

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies. [No Figure] ...

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16-04-2016 дата публикации

Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof

Номер: TW0201613972A
Принадлежит:

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

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04-04-2023 дата публикации

Reactive power compensation device at tail end of power distribution network

Номер: CN115912388A
Принадлежит:

The invention discloses a power distribution network tail end reactive power compensation device which comprises a shell, an indicator lamp, a first air switch, a current transformer, a hinge, an input power plug, a door plate, an antenna, a twisting handle, a reactive power compensation controller, a heat dissipation window, a heat dissipation fan, a capacitor bank, a second air switch, a power module and an Internet of Things module. A door plate is arranged on the front side of the shell, a first air switch, a current transformer and a reactive compensation controller are fixedly installed on the door plate in a transverse penetrating mode, two heat dissipation windows are symmetrically arranged on the two sides of the shell, and a heat dissipation fan is fixedly connected to the position, corresponding to one heat dissipation window, of one side of the inner side of the shell. The reactive power compensation device at the tail end of the power distribution network is connected with ...

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05-02-2014 дата публикации

Measuring equipment

Номер: CN103551399A
Принадлежит:

The invention discloses measuring equipment, which is used for measuring the thickness of a steel plate on-line. The measuring equipment comprises a support frame, an ultrasonic emission source, an ultrasonic reception source and calculation treatment equipment; the calculation treatment equipment is respectively connected with the ultrasonic emission source and the ultrasonic reception source by virtue of data lines; the calculation treatment equipment can be used for figuring out the thickness of the steel plate according to ray angles and relative locations of the ultrasonic emission source and the ultrasonic reception source; the measuring equipment further comprises an aftertreatment cooling device, which can be used for directly carrying out cooling treatment on the steel plate according to measurement results. The measuring equipment is high in accuracy, convenient and fast, the energy consumption of the cooling device is low, and the scale removal effect is good.

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09-06-1999 дата публикации

Mould pressed composite wall and floor and its producing technology

Номер: CN0001218775A
Принадлежит:

The production technique of press-moulding composite wall-and-floor includes wood fiber preparation, semi-finished wall-floor blank preparation, and preparation and installation of wall-and-floor. The ingiedients of the wall-and-floor are wood fiber 60-70 wt%, flyash 10-25 wt%, floated flyash bead 5-15 wt%, ammonium chloride 0.5-1.5 wt%, atoleine 2-4 wt%, and urea-formaldehyde resin adhesive 10-20 wt%. The product has the features of heat-insulating, waterproof and fireproof properties and convenience for decoration and construction.

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05-08-2009 дата публикации

Superhigh temperature wood carbonization method

Номер: CN0101497799A
Принадлежит:

The invention discloses an ultra-temperature wood dry distillation method which is characterized by comprising the following steps: A. placing wood in a dry distillation tank, heating the wood to 100-120 DEG C, and spraying steam on the surface of the wood and keeping for 2-3h; B. drying the wood to enable the water content of the wood to reach 3-4 percent; C. heating the wood to 150-200 DEG C and keeping for 8-10h; D. lowering the temperature in the dry distillation tank to 100 DEG C below, and spraying steam on the surface of the wood during the process. The method can be used for producing carbonized wood.

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01-04-2018 дата публикации

Antibodies against TIM3 and uses thereof

Номер: TW0201811829A
Принадлежит:

Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

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07-07-2023 дата публикации

Method for suppressing communication interference in sea clutter based on linear prediction

Номер: CN116400304A
Принадлежит:

The invention discloses a method for suppressing communication interference in sea clutters based on linear prediction, which comprises the following steps: step 1, echo data received by a radar are recorded as X, and X is an M * K-dimensional complex matrix; step 2, marking whether interference signals exist in each pulse to form a K-dimensional label vector; step 3, performing discrete Fourier transform on the complex matrix; step 4, calculating an interference detection threshold; step 5, carrying out interference filtering processing on the distance frequency domain data of the first pulse; and step 6, performing inverse discrete Fourier transform on the matrix to obtain a time domain data matrix after interference suppression. According to the method disclosed by the invention, linear prediction and interpolation are carried out on interference values of different frequency points by using adjacent non-interference data based on time correlation of sea clutters and target data, so ...

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23-06-2023 дата публикации

Warp tying method for special cloth

Номер: CN116288886A
Принадлежит:

The invention discloses a special cloth warp tying method which comprises the following steps: a preparation stage: configuring a first stranded wire for separating common yarns and special yarns in a loom in yarns of the loom, and configuring a second stranded wire for separating common yarns and special yarns in a size beam in yarns of the size beam; before warp tying, common yarn and special yarn in a loom are separated through a first stranded yarn, and common yarn and special yarn in a size beam are separated through a second stranded yarn; during warp tying, the common yarn in the size beam and the common yarn in the loom are subjected to warp tying through a warp tying machine, and the special yarn in the size beam and the special yarn in the loom are subjected to warp tying manually; by the adoption of the scheme, it can be guaranteed that special yarns are in butt joint during warp tying, common yarns can be subjected to warp tying through the warp tying machine, then the warp ...

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04-03-2015 дата публикации

Ramie and paper straw mix-woven mat and processing technology thereof

Номер: CN104382430A
Автор: LI HUIMING
Принадлежит:

The invention relates to a mat and a processing technology thereof, in particular to a ramie and paper straw mix-woven mat and the processing technology thereof. The ramie and paper straw mix-woven mat is formed by weaving ramie and paper straws in a mixed way. The processing technology of the ramie and paper straw mix-woven mat comprises the following steps of firstly manufacturing the paper straws into paper, cutting the paper into pieces according to the specification of the ramie and paper straw mix-woven mat, then taking the pieces as weft threads by rolling the pieces into rope shapes or core-spun cotton threads in the pieces to form the rope shapes, obtaining ramie fiber by carrying out chemical degumming on the ramie, soaking the ramie fiber by nano-silver antibiotic finishing agent solution of which the PH is 5.0-6.5, and taking the ramie fiber as warp threads for weaving after the ramie fiber is dried, so as to obtain a mat main body; obtaining a mat semi-finished product by carrying ...

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27-08-2021 дата публикации

Bridge supporting structure capable of effectively expanding tension for building

Номер: CN214061224U
Принадлежит: YIN SHAN, 银山

The utility model discloses a bridge supporting structure capable of effectively expanding tension for a building, which comprises a base, and the top surface of the base is fixedly connected with a cement column. The supporting plates and the rib plates are arranged on the two sides of the concrete column, so that the stability of a bridge can be effectively guaranteed, the supporting plates can effectively support the frame body, meanwhile, the n-shaped plates and the fixing rods are arranged, the supporting effect on the frame body can be effectively reinforced, it is guaranteed that the frame body is fixed to the concrete column, and the stability of the bridge is guaranteed. At the moment, the baffles are fixed to the two sides of the frame body, when the cross beam is fixed, the cross beam is effectively supported by inserting the first inserting rods into the inserting grooves, and the I-shaped plate and the baffles on the two sides are effectively fixed together by inserting the ...

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29-08-2017 дата публикации

Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof

Номер: US0009745379B2
Принадлежит: BRISTOL-MYERS SQUIBB COMPANY

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

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11-05-2011 дата публикации

Single-phase shell type amorphous alloy dry-type transformer body

Номер: CN0102054569A
Принадлежит:

The invention relates to a single-phase shell type amorphous alloy dry-type transformer body which comprises a shell type core, an iron yoke and a rectangular coil; the shell type core is formed by rolled amorphous alloy; an epoxy resin insulating piece is arranged on the outer side of the iron yoke; an upper positioning plate and a lower positioning plate are mounted on the upper end surface and the lower end surface of the inner side of the rectangular coil respectively, and an upper clamping piece and a lower clamping piece, which correspond to the upper positioning plate and the lower positioning plate, are arranged on the upper end surface and the lower end surface of the outer side of the rectangular coil respectively; a cushion block is arranged between the rectangular coil and the upper positioning plate; and a block is connected to the lower end of the lower clamping piece. Compared with the traditional single-phase dry-type transformer, the epoxy resin insulating piece is adopted ...

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23-06-2020 дата публикации

Anti-GITR antibodies for cancer diagnostics

Номер: US0010690674B2

Provided herein are diagnostic antibodies that bind to glucocorticoid-induced tumor necrosis factor receptor (GITR). Such antibodies are useful for methods of detecting the expression of GITR in biological samples, for example, tumor tissue, and identifying a cancer patient likely to respond to anti-GITR immunotherapy or predicting whether a cancer patient will respond to anti-GITR immunotherapy.

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17-12-2014 дата публикации

Processing technique for China-Hemp and paper straw mixed mat

Номер: CN104207561A
Автор: LI HUIMING
Принадлежит:

The invention relates to a processing technique for mats and particularly relates to a processing technique for a China-Hemp and paper straw mixed mat. The processing technique comprises the following steps: cutting waterproof paper into sheets according to specifications of the mat, then wrapping straws with sheety waterproof paper so as to form ropy paper and then reeling to form wefts, and taking China-Hemp as warps for knitting, so as to obtain a mat main body; spraying water by using an atomizer of a pressing machine, heating, pressing polish and carrying out shrinking treatment on the mat main body, so as to obtain a semi-finished mat; soaking the semi-finished mat into a waterproof agent solution with a pH value of 4.5 to 6.5, and then placing the semi-finished mat into a drying oven for drying; arranging well cut lining cloth on peripheries of the dried semi-finished mat, wrapping the semi-finished mat by using the lining cloth, enabling the lining cloth to be symmetric on upper ...

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25-10-2019 дата публикации

Cable crane device with automatic alignment, pressure bearing and shearing resistance

Номер: CN0209538035U

The utility model discloses a cable crane device with automatic alignment, pressure bearing and shearing resistance. The device comprises a lifting appliance connected with an end beam, heavy parts are fixed at the lower ends of the slings; cable clamps are arranged on the lower sides of the two ends of the end beams; a plurality of pressure-bearing anti-shearing blocks are further arranged at thelower end of the end beam and comprise top plates, bottom plates are fixed to the lower ends of the top plates, reverse hooks are arranged at the four corners of the upper end faces of the top plates, pin shafts are further fixed to the upper end faces of the top plates, end beam bottom plates are arranged on the bottom end face of the end beam, and multiple rows of pin shaft holes correspondingto the pin shafts are formed. The bolt fixing device is used for solving the problems that in a traditional bolt fixing mode between the pressure-bearing anti-shearing block and the end beam, a bolt hole ...

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08-08-2023 дата публикации

Fuze virtual training system, method and equipment and storage medium

Номер: CN116560501A
Принадлежит:

The invention discloses a fuze virtual training system, method and device and a storage medium. Wherein the virtual simulation training system is used for performing detailed three-dimensional viewing on the appearance and the construction principle of the fuze in a three-dimensional environment, designing a corresponding three-dimensional demonstration animation and automatically viewing a corresponding demonstration process; the virtual simulation assessment system is used for performing score assessment on the virtual simulation operation of the student and determining an assessment result; and the user management system is used for dividing different types of users and recording use data of each user in a classified manner, so that students can perform classified statistics and management on data of own permissions. According to the invention, based on virtual reality and man-machine interaction, a highly-simulated virtual environment and object are constructed, and trainees perform ...

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20-08-2014 дата публикации

Health care mooncake and preservative and fresh-keeping box structure thereof

Номер: CN103988871A
Принадлежит:

A health care mooncake comprises a filling core, the filling core is wrapped by a crisp layer which is wrapped by a malleable layer, and the malleable layer is wrapped by a dough layer which is wrapped by an egg liquid layer. According to a preservative and fresh-keeping box of the health care mooncake, a groove is formed in the fresh-keeping box, a layer of metal foil is composited on the inner surface of the groove, a preservative and fresh-keeping piece is composited on the metal foil at the bottom, and the health care mooncake is placed on the preservative and fresh-keeping piece. A box cover is buckled on the top of the preservative and fresh-keeping box, and a preservative and fresh-keeping piece is also composited on the inner surface of the box cover. The mooncake has the advantages of being unique in taste, rich in nutrition and the like, the defects of much oil and high heat of the mooncake are overcome due to the mooncake filling, and camellia oil, soybean peptide, konjac glucomannan ...

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20-01-2010 дата публикации

Method for realizing uniform authentication

Номер: CN0100583761C
Принадлежит:

The invention discloses a user centralization landing identification method, which comprises the following steps: building identification server; establishing user identification account number on identification server; saving user information of multisystems in identification server; linking up built user identification account number and saved user information of multisystems; providing identification sign for user client side which is provided by identification server; making user to use identification sign to enter several systems. The invention provides uniform user landing identification mechanism, which makes the user access applied system of severl authorization and service provider after the user the first landing identification.

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27-03-1996 дата публикации

Process for preparing colloidal Sb2O5 by chlorination hydrolysis

Номер: CN0001031397C
Принадлежит: SN MINE MINERAL BUREAU

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16-08-2011 дата публикации

Method for real-time monitoring a remote control process by a third party and system thereof

Номер: US0008001238B2

The invention relates to a remote monitor technique. In particular, the present invention relates to a method for real-time monitoring a remote control process by a third party and a system thereof, which are able to third-party monitor a control terminal and a controlled terminal in the remote control process. The method comprises steps of establishing a connection between a control terminal and a third party monitoring terminal; arranging the control terminal, the controlled terminal and the third party monitoring terminal in one and the same session based on the connection; the controlled terminal sending its desktop video to the third party monitoring terminal via a virtual display driver; and the third party monitoring terminal sending a predetermined control strategy to the controlled terminal.

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12-05-2023 дата публикации

Intelligent supervision system and method for enterprise management

Номер: CN116108097A
Принадлежит:

The invention discloses an intelligent supervision system and method for enterprise management. The system comprises a transformer substation different department relation unit, a transformer substation workflow determination unit, a management error screening unit, a transformer substation management specification setting unit, a customer demand communication unit, a transformer substation operation guarantee unit, a transformer substation personnel allocation management unit, a transformer substation voltage management unit and a transformer substation voltage promotion unit. And a voltage user feedback unit. According to the enterprise management intelligent supervision system and method provided by the invention, information data of different departments of a transformer substation needing compliance supervision are automatically found through an algorithm, information compliance supervision rules of the different departments of the transformer substation are uniformly formulated through ...

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08-07-2014 дата публикации

Method for implementing unified authentication

Номер: US8776201B2

A method for implementing unified authentication for user logon, the method comprising the steps of: establishing an authentication server; creating a user authentication account number in the authentication server; storing user information which the user uses in a plurality of systems into the authentication server; associating, in the authentication server, the created user authentication account number with the user information which the user uses in the plurality of systems; and providing an authentication flag to the client of the user by the authentication server based on the association between the user authentication account number and the user information which the user uses in the plurality of systems established in the authentication server so that the user can log on the plurality of systems using the authentication flag. The present invention is applied to provide a unified mechanism of user logon authentication in integration and mergence of the service processes provided ...

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10-11-2004 дата публикации

一种新型富含蛋白多肽的营养液的提取制备方法

Номер: CN0001544083A
Принадлежит:

The invention discloses a protein polypeptide obtained from animal serum, cerebrospinal fluid, brain tissue through homogenating, supersonic oscillation to obtain the the protein, which can be applied for taking. The polypeptide is characterized in rich raw material resource, easy production and rich nourishment.

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23-06-2023 дата публикации

Multifunctional isolation switch driving motor power detection system and method

Номер: CN116298496A
Принадлежит:

The invention relates to a multifunctional isolation switch driving motor power detection system and method, and belongs to the technical field of isolation switch driving motor power detection. The method comprises the steps that after power data of a disconnecting switch driving motor are obtained, the motor type is judged through a motor type judgment module according to the power data, and then a preset power calculation formula corresponding to the motor type is called through a motor power calculation module according to the motor type for power calculation. According to the technical scheme, power calculation formulas corresponding to all types are set according to three common motor types of the disconnecting switch, the mechanical performance detection method is suitable for mechanical performance detection of the disconnecting switch of three driving motors, and compared with the prior art that only one type of motor of a three-phase asynchronous motor can be detected, the application ...

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23-05-2012 дата публикации

Oxidation process for aromatic compound

Номер: CN0101423469B
Принадлежит:

The invention can use tert-butyl hydroperoxide and microwave radiation for oxidizing the methylene-substituted aromatic compound. Specially, xylol mainly generates benzene dicarboxylic acid, and toluene generates benzoic acid. The methylene-substituted aromatic compound generates ketone and does not generate acid, wherein the methylene is not methyl part. For example, fluorene generates fluorenone. The method prevents the requirement of existence of metal in catalyst or oxidant. Furthermore the water can be used and the organic solvent is not required. Therefore the method can accord with the ideal of green chemistry.

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16-04-2014 дата публикации

Reinforcement cage pushing gear for manufacturing of tunnel immersed tubes

Номер: CN103726509A
Принадлежит:

The invention relates to the field of manufacturing of subsea tunnel immersed tubes, in particular to a reinforcement cage pushing gear for manufacturing of tunnel immersed tubes. The reinforcement cage pushing gear comprises a plurality of sliding rails, a plurality of sliding square sections, a pushing beam and a power device, wherein the sliding square sections are arranged on the sliding rails in a one-to-one correspondence mode. The pushing beam is fixedly connected with the multiple sliding square sections, the power device drives the pushing beam to drive the sliding square sections to slide on the sliding rails, and each sliding square section is provided with a dust cover. Through the dust covers, dust and the like in a site can be effectively prevented from dropping into the sliding rails, and frictional resistance in the sliding process is reduced; the interiors of the sliding rails are coated with lubricating oil, relevant surface smoothness processing is conducted on the interiors ...

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12-02-2014 дата публикации

Steel plate cooling device

Номер: CN103567238A
Принадлежит:

Disclosed is a steel plate cooling device. The steel plate cooling device comprises an upper-side cooling device and a lower-side cooling device. The upper-side cooling device and the lower-side cooling device are evenly provided with a plurality of atomization cooling nozzles. The atomization cooling nozzles installed on the upper-side cooling device and the lower-side cooling device vertically correspond to each other. The range of the included angles between the atomization cooling nozzles and the forward-motion direction of a steel plate is 30-75 degrees. The steel plate cooling device further comprises an induction measurement device and a control device. When the steel plate cooling device is used, burdens can be economically reduced, and the high consistency of finished products can be texturally kept.

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14-01-2020 дата публикации

Antibodies against TIM3 and uses thereof

Номер: US0010533052B2

Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

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23-07-2014 дата публикации

Shield tail sealing grease used for shield tunneling machine

Номер: CN103937590A
Принадлежит:

The invention discloses a shield tail sealing grease used for a shield tunneling machine. The grease comprises following components, by mass, 15%-25% of base oil, 20%-30% of a powdery filling material, 8%-15% of a thickening agent, 2%-8% of tackifier, 0.5%-5% of an auxiliary dispersant, 16%-33% of a waterproof sealing material and 0.1%-3% of an antistatic agent. Compared with present sealing grease, the shield tail sealing grease prepared through a formula of the invention is good in anti-hydraulic-pressure sealing property, adhesiveness and pumping performance. The sealing grease is great in water washout resistance and is free of water leakage and grease leakage at room temperature and under 3.7 Mpa. The sealing grease is excellent in pumping performance with a pumping rate being 44g/min at 20 DEG C and under 10 Bar. The sealing grease can keep a great pumping performance even if the sealing grease is used in a low-temperature environment, which significantly reduces blocking of grease-injection ...

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13-01-2016 дата публикации

Medical cavity form apparatus wash rack

Номер: CN0204953462U
Автор: LI HUIMING, SUN XIAOHUA
Принадлежит:

... (B, ) the utility model relates to a people's flow tube rinses auxiliary device technical field, is a medical cavity form apparatus wash rack, and it includes frame body, slope bridge, slope pole and recess frame, frame body lower floor is fixed with a pair of slope bridge that distributes of controlling, the slope pole that distributes and have many parallels and slope to the inboard top on the bridge that slopes, and the front outline of both sides slope pole is parallel just crisscross arranging, the recess frame that corresponds the crossing position department of both sides slope pole extension line is fixed on frame body upper strata, is equipped with on the recess frame and inclines pole corresponding match's arc recess one by one. The utility model has the advantages of reasonable and compact structure, convenient to use, it is through the cooperation of slope pole and arc recess, will the many tilting fixed that people's flow tube is reliable and stable, rinse simultaneously, and ...

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06-05-2009 дата публикации

Oxidation process for aromatic compound

Номер: CN0101423469A
Принадлежит:

The invention can use tert-butyl hydroperoxide and microwave radiation for oxidizing the methylene-substituted aromatic compound. Specially, xylol mainly generates benzene dicarboxylic acid, and toluene generates benzoic acid. The methylene-substituted aromatic compound generates ketone and does not generate acid, wherein the methylene is not methyl part. For example, fluorene generates fluorenone. The method prevents the requirement of existence of metal in catalyst or oxidant. Furthermore the water can be used and the organic solvent is not required. Therefore the method can accord with the ideal of green chemistry.

Подробнее
21-07-2023 дата публикации

Battery pack cut-off unit and battery pack charge and discharge control circuit

Номер: CN116461336A
Принадлежит:

The invention provides a battery pack cut-off unit and a battery pack charge and discharge control circuit. The battery pack cut-off unit is used for controlling charging and discharging of the battery pack. The battery pack cut-off unit comprises a positive electrode high-voltage control box and a negative electrode high-voltage control box, and the negative electrode high-voltage control box and the positive electrode high-voltage control box are assembled. The anode high-voltage control box is provided with a plurality of anode high-voltage terminals, the cathode high-voltage control box is provided with a plurality of cathode high-voltage terminals, and the plurality of cathode high-voltage terminals are correspondingly and electrically connected with the plurality of anode high-voltage terminals. The battery pack charging and discharging control circuit comprises a battery pack, a controller, a high-voltage charging power supply and the battery pack cut-off unit. The battery pack cut-off ...

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07-10-2015 дата публикации

Cutting is used for processing sawing machine of tire mould graphite

Номер: CN0204687102U
Принадлежит:

The utility model discloses a cutting is used for processing sawing machine of tire mould graphite, sawing machine are equipped with and are used for placing the cutting panel of waiting to cut graphite, the cutting panel passes through the base to be fixed subaerial, upper portion and the lower part of cutting panel one end be equipped with respectively the fixed saw blade of cooperation from driving wheel and action wheel, the action wheel rotatory by actuating mechanism drive. The utility model has the advantages of it is convenient to use, and the cutting efficiency and the precision of improvement graphite that can be very big reduce staff intensity of labour.

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26-05-2016 дата публикации

ANTIBODIES AGAINST GLUCOCORTICOID-INDUCED TUMOR NECROSIS FACTOR RECEPTOR (GITR) AND USES THEREOF

Номер: US20160145342A1
Принадлежит:

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies. 128-. (canceled)29. An isolated antibody , or antigen binding portion thereof , which binds to human glucocorticoid-inducible TNF receptor (GITR) , comprising heavy chain CDR1 , CDR2 , and CDR3 sequences comprising SEQ ID NOs: 20 , 21 , and 22 , respectively , and light chain CDR1 , CDR2 , and CDR3 sequences comprising SEQ ID NOs: 23 , 24 , and 25 , respectively , wherein the antibody binds to membrane-bound human GITR.30. The isolated antibody claim 29 , or antigen binding portion thereof claim 29 , of claim 29 , wherein the antibody binds to membrane-bound human GITR with a Kof 10 nM or less as determined by Scatchard analysis.31. The isolated antibody claim 29 , or antigen binding portion thereof claim 29 , of claim 29 , wherein the antibody binds to membrane-bound human GITR with a Kof 1 nM or less as determined by Scatchard analysis.32. The isolated antibody claim 29 , or antigen binding portion thereof claim 29 , of claim 29 , wherein the antibody claim 29 , or antigen binding portion thereof claim 29 , binds to membrane-bound GITR on activated human T cells.33. The isolated antibody claim 29 , or antigen binding portion thereof claim 29 , of claim 29 , wherein the antibody claim 29 , or antigen binding portion thereof claim 29 , binds to membrane-bound GITR on 3A9 cells ectopically expressing human GITR.34. The isolated antibody claim 29 , or antigen binding portion thereof claim 29 , of claim 29 , which is a human antibody or antigen binding portion thereof.35. The ...

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14-01-2021 дата публикации

ANTI-GITR ANTIBODIES FOR CANCER DIAGNOSTICS

Номер: US20210011022A1
Принадлежит: BRISTOL-MYERS SQUIBB COMPANY

Provided herein are diagnostic antibodies that bind to glucocorticoid-induced tumor necrosis factor receptor (GITR). Such antibodies are useful for methods of detecting the expression of GITR in biological samples, for example, tumor tissue, and identifying a cancer patient likely to respond to anti-GITR immunotherapy or predicting whether a cancer patient will respond to anti-GITR immunotherapy. 139-. (canceled)40. A chimeric antibody which binds to human glucocorticoid-induced tumor necrosis factor receptor (GITR) and comprises a heavy chain comprising a heavy chain constant region , and a light chain comprising a light chain constant region , wherein the heavy chain comprises heavy chain variable region CDR1 , CDR2 , and CDR3 comprising the amino acid sequences set forth in SEQ ID NOs: 5-7 , respectively , and the light chain comprises light chain variable region CDR1 , CDR2 , and CDR3 comprising the amino acid sequences set forth in SEQ ID NOs: 8-10 , respectively , wherein the heavy chain constant region is a non-human constant region.41. The antibody of claim 40 , wherein the non-human constant region comprises a mouse Fc region.42. The antibody of claim 41 , wherein the mouse Fc region is a mouse IgG2a Fc region.43. The antibody of claim 40 , wherein the antibody comprises the heavy and light chain sequences set forth in SEQ ID NOs: 15 and 16 claim 40 , respectively.44. The antibody of claim 40 , wherein the antibody comprises a detectable moiety.45. The antibody of claim 44 , wherein the detectable moiety is selected from the group consisting of: a radiolabel claim 44 , a fluorescent label claim 44 , an enzymatic label claim 44 , biotin claim 44 , a chromophore claim 44 , and an ECL label.46. The antibody of claim 45 , wherein the detectable moiety is a fluorescent label claim 45 , and wherein the fluorescent label is FITC.47. A nucleic acid encoding the heavy chain and light chain of the antibody of .48. An expression vector comprising the nucleic acid of . ...

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05-11-2019 дата публикации

Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof

Номер: US0010465010B2

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

Подробнее
04-01-2018 дата публикации

ANTIBODIES AGAINST GLUCOCORTICOID-INDUCED TUMOR NECROSIS FACTOR RECEPTOR (GITR) AND USES THEREOF

Номер: US20180002432A1
Принадлежит:

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies. 1. An isolated antibody which binds to human glucocorticoid-inducible TNF receptor (GITR) , comprising:(a) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 20, 21, and 22, respectively, and light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 23, 24, and 25, respectively;(b) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 33, 34, and 35, respectively, and light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 36, 37, and 38, respectively;(c) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 46, 47, and 48, respectively, and light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 49, 50, and 51, respectively;(d) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 62, 63, and 64, respectively, and light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 65, 66, and 67, respectively;(e) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 62, 63, and 64, respectively, and light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 68, 69, and 70, respectively;(f) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 78, 79, and 80, respectively, and light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 81, 82, and 83, respectively;(g) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 91, 92, and 93, respectively, and light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 94, 95, and 96, respectively;(h) heavy ...

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18-01-2018 дата публикации

ANTIBODIES AGAINST TIM3 AND USES THEREOF

Номер: US20180016336A1
Принадлежит: BRISTOL-MYERS SQUIBB COMPANY

Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof. 180-. (canceled)81. An isolated antibody , which binds to a human TIM3 , comprising: (a1) a heavy chain CDR1, CDR2, and CDR3 of SEQ ID NOs: 41, 122, and 126, respectively, and a light chain CDR1, CDR2, and CDR3 of SEQ ID NOs: 64, 66, and 68, respectively;', '(a2) a heavy chain CDR1, CDR2, and CDR3 of SEQ ID NOs: 41, 122, and 128, respectively, and a light chain CDR1, CDR2, and CDR3 of SEQ ID NOs: 64, 66, and 68, respectively;', '(a3) a heavy chain CDR1, CDR2, and CDR3 of SEQ ID NOs: 41, 46, and 129, respectively, and a light chain CDR1, CDR2, and CDR3 of SEQ ID NOs: 64, 66, and 68, respectively;', '(a4) a heavy chain CDR1, CDR2, and CDR3 of SEQ ID NOs: 41, 46, and 128, respectively, and a light chain CDR1, CDR2, and CDR3 of SEQ ID NOs: 64, 66, and 68, respectively;', '(a5) a heavy chain CDR1, CDR2, and CDR3 of SEQ ID NOs: 41, 46, and 127, respectively, and a light chain CDR1, CDR2, and CDR3 of SEQ ID NOs: 64, 66, and 68, respectively;', '(a6) a heavy chain CDR1, CDR2, and CDR3 of SEQ ID NOs: 41, 46, and 126, respectively, and a light chain CDR1, CDR2, and CDR3 of SEQ ID NOs: 64, 66, and 68, respectively;', '(a7) a heavy chain CDR1, CDR2, and CDR3 of SEQ ID NOs: 41, 124, and 53, respectively, and a light chain CDR1, CDR2, and CDR3 of SEQ ID NOs: 64, 66, and 68, respectively;', '(a8) a heavy chain CDR1, CDR2, and CDR3 of SEQ ID NOs: 41 ...

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24-03-2022 дата публикации

ANTIBODIES AGAINST TIM3 AND USES THEREOF

Номер: US20220089720A1
Принадлежит: BRISTOL-MYERS SQUIBB COMPANY

Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof. 17-. (canceled)8. An isolated antibody , which binds to human T-cell immunoglobulin and mucin-domain containing-3 (TIM3) , comprising a heavy chain CDR1 , CDR2 , and CDR3 and a light chain CDR1 , CDR2 , and CDR3 , wherein:(a) the heavy chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs: 45, 413, and 414, respectively, and the light chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs: 64, 66, and 69, respectively;(b) the heavy chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs: 45, 415, and 416, respectively, and the light chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs: 64, 66, and 68, respectively; or(c) the heavy chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs: 45, 415, and 416, respectively, and the light chain CDR1, CDR2, and CDR3 comprise SEQ ID NOs: 64, 66, and 419, respectively.911-. (canceled)12. The isolated antibody of claim 8 , comprising a heavy chain variable region (VH) and a light chain variable region (VL) claim 8 , wherein the VH comprises an amino acid sequence which is at least about 80% claim 8 , at least about 85% claim 8 , at least about 90% claim 8 , at least about 95% claim 8 , at least about 96% claim 8 , at least about 97% claim 8 , at least about 98% claim 8 , at least about 99% claim 8 , or about 100% identical to the amino acid sequence set forth as SEQ ID NO: 410 or 411.13. The isolated antibody of claim 8 , comprising ...

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12-03-2020 дата публикации

ANTIBODIES AGAINST GLUCOCORTICOID-INDUCED TUMOR NECROSIS FACTOR RECEPTOR (GITR) AND USES THEREOF

Номер: US20200079865A1
Принадлежит:

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies. 128-. (canceled)29. An isolated antibody which binds to glucocorticoid-inducible TNF receptor (GITR) , comprising:(a) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 33, 34, and 35, respectively, and/or light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 36, 37, and 38, respectively;(b) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 46, 47, and 48, respectively, and/or light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 49, 50, and 51, respectively;(c) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 62, 63, and 64, respectively, and/or light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 65, 66, and 67, respectively;(d) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 62, 63, and 64, respectively, and/or light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 68, 69, and 70, respectively;(e) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 78, 79, and 80, respectively, and/or light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 81, 82, and 83, respectively;(f) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 91, 92, and 93, respectively, and/or light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 94, 95, and 96, respectively;(g) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 106, 107, and 108, respectively, and/or light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 109 ...

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09-06-2022 дата публикации

ANTIBODIES AGAINST GLUCOCORTICOID-INDUCED TUMOR NECROSIS FACTOR RECEPTOR (GITR) AND USES THEREOF

Номер: US20220175921A1
Принадлежит:

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies. 168-. (canceled)69. A method for inhibiting the growth of tumor cells in a subject , the method comprising administering to the subject an antibody that binds to human glucocorticoid-inducible TNF receptor (GITR) and comprises a heavy chain constant region comprising (1) an amino acid sequence selected from the group consisting of SEQ ID NOs: 223-226 , 283-290 , 383-446 and 480-543 or (2) a heavy chain constant region that differs therefrom in at most 5 amino acids or is at least 95% , 96% , 97% , 98% or 99% identical to an amino acid sequence of SEQ ID NOs: 223-226 , 283-290 , 383-446 and 480-543 , wherein the amino acid modification(s) are not at the specific amino acid(s) in SEQ ID NOs: 223-226 , 283-290 , 383-446 and 480-543 that are not present in the naturally-occurring human heavy chain constant regions.70. The method of claim 69 , wherein the antibody comprises:(a) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 20, 21, and 22, respectively, and/or light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 23, 24, and 25, respectively;(b) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 33, 34, and 35, respectively, and/or light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 36, 37, and 38, respectively;(c) heavy chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 46, 47, and 48, respectively, and/or light chain CDR1, CDR2, and CDR3 sequences comprising SEQ ID NOs: 49, 50, and 51, respectively;(d) heavy chain ...

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14-06-2018 дата публикации

Anti-gitr antibodies for cancer diagnostics

Номер: US20180164321A1
Принадлежит: Bristol Myers Squibb Co

Provided herein are diagnostic antibodies that bind to glucocorticoid-induced tumor necrosis factor receptor (GITR). Such antibodies are useful for methods of detecting the expression of GITR in biological samples, for example, tumor tissue, and identifying a cancer patient likely to respond to anti-GITR immunotherapy or predicting whether a cancer patient will respond to anti-GITR immunotherapy.

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10-12-2015 дата публикации

ANTIBODIES AGAINST GLUCOCORTICOID-INDUCED TUMOR NECROSIS FACTOR RECEPTOR (GITR) AND USES THEREOF

Номер: US20150353637A1
Принадлежит:

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies. 1. An isolated monoclonal antibody , or antigen binding portion thereof , which binds to human glucocorticoid-inducible TNF receptor (GITR) , comprising heavy chain CDR1 , CDR2 , and CDR3 sequences comprising SEQ ID NOs: 20 , 21 , and 22 , respectively , and light chain CDR1 , CDR2 , and CDR3 sequences comprising SEQ ID NOs: 23 , 24 , and 25 , respectively.24-. (canceled)5. The antibody claim 1 , or antigen binding portion thereof claim 1 , of claim 1 , wherein the antibody stimulates a T cell response.6. The antibody claim 1 , or antigen binding portion thereof claim 1 , of claim 1 , wherein the antibody binds to soluble human GITR with a Kof 10 nM or less as measured by Biacore.7. The isolated monoclonal antibody claim 1 , or antigen binding portion thereof claim 1 , of claim 1 , which comprises heavy and light chain variable region sequences set forth in SEQ ID NOs: 13 and 14 claim 1 , respectively.810-. (canceled)1218-. (canceled)19. A nucleic acid encoding the heavy and/or light chain variable region of the antibody claim 1 , or antigen binding portion thereof claim 1 , of .20. A composition comprising the antibody claim 1 , or antigen binding portion thereof claim 1 , of and a carrier.21. A composition comprising the antibody claim 1 , or antigen binding portion thereof claim 1 , of and one or more additional therapeutics.22. The composition of claim 21 , wherein the one or more additional therapeutics are selected from the group consisting of: an anti-PD1 antibody claim 21 ...

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10-12-2015 дата публикации

Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof

Номер: WO2015187835A2
Принадлежит: BRISTOL-MYERS SQUIBB COMPANY

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid- inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

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26-05-2017 дата публикации

Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof

Номер: WO2017087678A2
Принадлежит: BRISTOL-MYERS SQUIBB COMPANY

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

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18-01-2018 дата публикации

Antibodies against tim3 and uses thereof

Номер: WO2018013818A2
Принадлежит: BRISTOL-MYERS SQUIBB COMPANY

Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

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18-07-2019 дата публикации

Antibodies against tim3 and uses thereof

Номер: WO2019140229A1
Принадлежит: BRISTOL-MYERS SQUIBB COMPANY

Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.

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18-05-2022 дата публикации

Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof

Номер: EP3998079A1
Принадлежит: Bristol Myers Squibb Co

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

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19-02-2020 дата публикации

Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof

Номер: EP3610924A1
Принадлежит: Bristol Myers Squibb Co

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

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24-05-2022 дата публикации

Antibodies against tim3 and uses thereof

Номер: JP2022078102A
Принадлежит: Bristol Myers Squibb Co

【課題】がんの免疫療法を改善するための、TIM3を標的とする薬剤を提供する。【解決手段】ヒトT細胞免疫グロブリンおよびムチンドメイン含有3(TIM3)と結合する、単離された抗体(例えば、ヒト抗体)またはその抗原結合部分であって、以下の特性:(a)可溶性ヒトTIM3と結合すること、(b)膜結合型ヒトTIM3と結合すること、(c)T細胞活性化を誘導または増強すること、ならびに適宜(d)可溶性カニクイザルTIM3と結合すること、および(e)膜カニクイザルTIM3と結合することを示す、抗体またはその抗原結合部分を使用する。【選択図】なし

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04-01-2022 дата публикации

Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR)

Номер: US11213586B2
Принадлежит: Bristol Myers Squibb Co

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

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09-08-2022 дата публикации

Anti-GITR antibodies for cancer diagnostics

Номер: US11408889B2
Принадлежит: Bristol Myers Squibb Co

Provided herein are diagnostic antibodies that bind to glucocorticoid-induced tumor necrosis factor receptor (GITR). Such antibodies are useful for methods of detecting the expression of GITR in biological samples, for example, tumor tissue, and identifying a cancer patient likely to respond to anti-GITR immunotherapy or predicting whether a cancer patient will respond to anti-GITR immunotherapy.

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27-01-2021 дата публикации

ANTIBODIES AGAINST Glucocorticoid-stimulated tumor necrosis factor receptor (GITR) and uses thereof

Номер: CY1122389T1
Принадлежит: BRISTOL-MYERS SQUIBB COMPANY

Παρεχόμενα στο παρόν είναι αντισώματα ή τμήματα σύνδεσης αντιγόνου αυτών, που συνδέονται σε διεγειρόμενο με γλυκοκορτικοειδές υποδοχέα TNF (GITR). Επίσης παρεχόμενες είναι χρήσεις αυτών των πρωτεϊνών σε θεραπευτικές εφαρμογές, όπως στη θεραπεία καρκίνου. Περαιτέρω παρεχόμενα είναι κύτταρα που παράγουν τα αντισώματα, πολυνουκλεοτίδια που κωδικοποιούν τη μεταβλητή περιοχή βαριάς ή/και ελαφράς αλύσου των αντισωμάτων και φορείς που περιλαμβάνουν τα πολυνουκλεοτίδια που κωδικοποιούν τη μεταβλητή περιοχή βαριάς ή/και ελαφράς αλύσου των αντισωμάτων. Provided herein are antibodies, or antigen binding fragments thereof, that bind to glucocorticoid-stimulated TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

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19-02-2018 дата публикации

Anti-gitr antibodies for cancer diagnostics.

Номер: MX2017015260A
Принадлежит: Squibb Bristol Myers Co

Se proporcionan en la presente los anticuerpos de diagnóstico, que se fijan al receptor del factor de necrosis tumoral (GITR) inducido por glucocorticoide. Tales anticuerpos son útiles para los métodos de detección de la expresión de GITR en muestras biológicas, por ejemplo, tejido tumoral, y se identifica a un paciente con cáncer que probablemente responde a la inmunoterapia anti-GITR, o se predice si un paciente con cáncer responderá o no a una inmunoterapia anti-GITR.

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01-08-2018 дата публикации

Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof.

Номер: MX2018006072A
Принадлежит: Squibb Bristol Myers Co

La presente invención se refiere a anticuerpos, o porciones de los mismos de unión al antígeno, que se unen al receptor del TNF inducible por glucocorticoide (GITR). También se proporcionan usos de estas proteínas en aplicaciones terapéuticas, tales como en el tratamiento de cáncer. Además, se proporcionan células que producen los anticuerpos, polinucleótidos que codifican la región variable de cadena pesada y/o ligera de los anticuerpos, y vectores que comprenden los polinucleótidos que codifican la región variable de cadena pesada y/o ligera de los anticuerpos.

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31-05-2022 дата публикации

Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof

Номер: CA2951234C
Принадлежит: Bristol Myers Squibb Co

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid- inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

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25-11-2021 дата публикации

Methods of treating cancer with antibodies against tim3

Номер: US20210363242A1
Принадлежит: Bristol Myers Squibb Co

This disclosure provides a method for treating a subject afflicted with a tumor or a cancer, wherein the method comprises administering to the subject therapeutically effective amounts of an anti-TIM3 antibody, alone or in combination with an inhibitor of the PD-1 signaling pathway (e.g., anti-PD-1 antibody). In some embodiments, the antibody is administered as a flat dose or a weight-based dose.

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27-08-2009 дата публикации

Method For Implementing Unified Authentication

Номер: US20090217366A1
Принадлежит: Lenovo Beijing Ltd

A method for implementing unified authentication for user logon, the method comprising the steps of: establishing an authentication server; creating a user authentication account number in the authentication server; storing user information which the user uses in a plurality of systems into the authentication server; associating, in the authentication server, the created user authentication account number with the user information which the user uses in the plurality of systems; and providing an authentication flag to the client of the user by the authentication server based on the association between the user authentication account number and the user information which the user uses in the plurality of systems established in the authentication server so that the user can log on the plurality of systems using the authentication flag. The present invention is applied to provide a unified mechanism of user logon authentication in integration and mergence of the service processes provided by a plurality of Internet information systems or Internet providers, and thus the user can access all authorized application systems or service providers with only one logon authentication.

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30-11-2023 дата публикации

Antibodies against tim3 and uses thereof

Номер: US20230382992A1
Принадлежит: Bristol Myers Squibb Co

Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

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30-01-2024 дата публикации

Tim3に対する抗体およびその使用

Номер: JP2024012285A
Принадлежит: Bristol Myers Squibb Co

【課題】T細胞免疫グロブリンおよびムチンドメイン含有3(TIM3)タンパク質に結合する抗体またはその抗原結合部分、癌処置などの治療適用における、これら抗体またはその抗原結合部分の使用を提供する。さらに、抗体またはその抗原結合部分を産生する細胞、抗体またはその抗原結合部分の重鎖および/または軽鎖領域をコードするポリヌクレオチドおよび抗体またはその抗原結合部分の重鎖および/または軽鎖領域をコードするポリヌクレオチドを含むベクターを提供する。【解決手段】ヒトT細胞免疫グロブリンおよびムチンドメイン含有3(TIM3)に結合し、それぞれ特定の配列を含む、重鎖CDR1、CDR2およびCDR3および軽鎖CDR1、CDR2およびCDR3を含む、単離抗体を提供する。【選択図】なし

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21-02-2024 дата публикации

Tim3に対する抗体およびその使用

Номер: JP2024023302A
Принадлежит: Bristol Myers Squibb Co

【課題】新しいがんの免疫療法を設計し、従来的ながんの免疫療法を改善するためのT細胞免疫グロブリンおよびムチンドメイン含有3(TIM3)を標的とする薬剤およびそのような薬剤を使用する方法を提供する。【解決手段】TIM3タンパク質と結合する抗体またはその抗原結合部分が、本明細書において提供される。治療用途、例えば、がんの処置における、これらの抗体またはその抗原結合部分の使用もまた、提供される。抗体またはその抗原結合部分を産生する細胞、抗体またはその抗原結合部分の重鎖および/または軽鎖領域をコードするポリヌクレオチド、ならびに抗体またはその抗原結合部分の重鎖および/または軽鎖領域をコードするポリヌクレオチドを含むベクターが、さらに提供される。【選択図】なし

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31-10-2023 дата публикации

Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof

Номер: US11802162B2
Принадлежит: Bristol Myers Squibb Co

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

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04-01-2024 дата публикации

Antibodies against tim3 and uses thereof

Номер: MY200602A
Принадлежит: Bristol Myers Squibb Co

ANTIBODIES AGAINST TIM3 AND USES THEREOF Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

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16-05-2024 дата публикации

Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof

Номер: US20240158524A1
Принадлежит: Bristol Myers Squibb Co

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

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12-02-2016 дата публикации

Automovil.

Номер: CL2015002284S1
Принадлежит: Great Wall Motor Co Ltd

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05-04-2024 дата публикации

Vacuum-flocculation-solidification integrated apparatus for waste mud and using method thereof

Номер: LU505229B1
Принадлежит: Univ Zhejiang City College

A vacuum-flocculation-solidification integrated apparatus for waste mud and a using method thereof are provided, and the apparatus includes an outer support truss, a vacuum barrel wall, a flocculation stirring device, and a rotary spraying solidification device. The using method of the apparatus includes: flattening a site and installing a support truss and a vacuum barrel wall; assembling a flocculation stirring device and then hoisting and installing to a top of the vacuum barrel wall; checking an air tightness; adding an APAM flocculant, starting the flocculation stirring device and a vacuum pump; starting an air compressor; and squeezing solidified soil from soil outlets. Beneficial effects of apparatus are that: multiple procedures of flocculation, vacuum drainage, solidification and discharging soil for the waste mud are continuously performed; a solidification agent is fully mixed with solidified soil through rotary spraying; and the apparatus is convenient to be disassembled, reassembled, and reused.

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24-10-2023 дата публикации

Vacuum-flocculation-solidification integrated apparatus for waste mud and using method thereof

Номер: US11795075B1
Принадлежит: Hangzhou City University

A vacuum-flocculation-solidification integrated apparatus for waste mud and a using method thereof are provided, and the apparatus includes an outer support truss, a vacuum barrel wall, a flocculation stirring device, and a rotary spraying solidification device. The using method of the apparatus includes: flattening a site and installing a support truss and a vacuum barrel wall; assembling a flocculation stirring device and then hoisting and installing to a top of the vacuum barrel wall; checking an air tightness; adding an APAM flocculant, starting the flocculation stirring device and a vacuum pump; starting an air compressor; and squeezing solidified soil from soil outlets. Beneficial effects of apparatus are that: multiple procedures of flocculation, vacuum drainage, solidification and discharging soil for the waste mud are continuously performed; a solidification agent is fully mixed with solidified soil through rotary spraying; and the apparatus is convenient to be disassembled, reassembled, and reused.

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30-05-2024 дата публикации

Methods of treating cancer with antibodies against tim3

Номер: US20240174749A1
Принадлежит: Bristol Myers Squibb Co

This disclosure provides a method for treating a subject afflicted with a tumor or a cancer, wherein the method comprises administering to the subject therapeutically effective amounts of an anti-TIM3 antibody, alone or in combination with an inhibitor of the PD-1 signaling pathway (e.g., anti-PD-1 antibody). In some embodiments, the antibody is administered as a flat dose or a weight-based dose.

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03-04-2020 дата публикации

一种电池模组组件及车辆

Номер: CN210245569U

本实用新型提供一种电池模组组件,包括电池模组、电池包底盘、固定轴和磁性安装部,所述电池包底盘设置在所述电池模组的下方,所述固定轴设置在所述电池模组上,所述磁性安装部设置在所述电池包底盘上,所述电池模组通过所述固定轴和所述磁性安装部拆卸安装在所述电池包底盘上;在所述电池模组组件的基础上,本实用新型还保护一种车辆,包括车身和上述电池模组组件,所述电池包底盘设置车身上。本实用新型提供的一种电池模组组件,结构简单,无需外加其他工具即可实现对所述电池模组的拆卸、更换和安装,节省工时和成本;其中多个所述电池模组之间可互相独立,能够提高单个所述电池模组的利用效率。

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03-08-2023 дата публикации

Temperature monitoring apparatus and battery module having same

Номер: US20230243707A1

A temperature monitoring apparatus and a battery module having the temperature monitoring apparatus. The temperature monitoring apparatus comprises an isolation plate, a connecting aluminum bar, a flexible printed circuit board, and a temperature measuring assembly. A first mounting frame and a second mounting frame are provided on the isolation plate. The connecting aluminum bar is embedded in the first mounting frame. The flexible printed circuit board is laid on the surface of the isolation plate in a manner of partially overlapping with the second mounting frame. The temperature measuring assembly is provided on the part of the flexible printed circuit board where the flexible circuit board overlaps the second mounting frame.

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20-09-2022 дата публикации

Intelligent method for diagnosing mechanical fault of high-voltage isolating switch based on transfer learning

Номер: NL2032669A

The present disclosure relates to the technical field of intelligent diagnosis for a high-voltage isolating switch, and in particular, to an intelligent method for diagnosing a 5 mechanical fault of a high-voltage isolating switch based on transfer learning. The method includes: obtaining a large number of power-time signals of a driving motor under various mechanical states of the high-voltage isolating switch by using an electromechanical co-simulation technology, training a multilayer neural network model by using the obtained simulation results as training samples, and further training last 10 several layers of the multilayer neural network by using experimental or field measurement data as small samples, to achieve optimal parameters for a single or composite fault diagnosis model. The present disclosure can solve the problem of low accuracy of an intelligent diagnosis algorithm of the high-voltage isolating switch due to insufficient training samples, and can improve the accuracy of the technology for 15 mechanical state diagnosis of the high-voltage isolating switch based on the deep neural network, thus making an intelligent diagnosis result of the high-voltage isolating switch recognized by industry.

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10-05-2023 дата публикации

Temperature monitoring apparatus and battery module having same

Номер: EP4177584A1

A temperature monitoring apparatus and a battery module having the temperature monitoring apparatus. The temperature monitoring apparatus comprises an isolation plate (3), a connecting aluminum bar (4), a flexible printed circuit board (2). and a temperature measuring assembly (5). A first mounting frame (31) and a second mounting frame (32) are provided on the isolation plate (3). The connecting aluminum bar (4) is embedded in the first mounting frame (31). The flexible printed circuit board (2) is laid on the surface of the isolation plate (3) in a manner of partially overlapping with the second mounting frame (32). The temperature measuring assembly (5) is provided on the part of the flexible printed circuit board (2) where the flexible circuit board (2) overlaps the second mounting frame (32).

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23-05-2023 дата публикации

Intelligent method for diagnosing mechanical fault of high-voltage isolating switch based on transfer learning

Номер: NL2032669B1

The present disclosure relates to the technical field of intelligent diagnosis for a high-voltage isolating switch, and in particular, to an intelligent method for diagnosing a 5 mechanical fault of a high-voltage isolating switch based on transfer learning. The method includes: obtaining a large number of power-time signals of a driving motor under various mechanical states of the high-voltage isolating switch by using an electromechanical co-simulation technology, training a multilayer neural network model by using the obtained simulation results as training samples, and further training last 10 several layers of the multilayer neural network by using experimental or field measurement data as small samples, to achieve optimal parameters for a single or composite fault diagnosis model. The present disclosure can solve the problem of low accuracy of an intelligent diagnosis algorithm of the high-voltage isolating switch due to insufficient training samples, and can improve the accuracy of the technology for 15 mechanical state diagnosis of the high-voltage isolating switch based on the deep neural network, thus making an intelligent diagnosis result of the high-voltage isolating switch recognized by industry.

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27-06-2024 дата публикации

Antibodies against tim3 and uses thereof

Номер: US20240209083A1
Принадлежит: Bristol Myers Squibb Co

Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

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29-10-2024 дата публикации

Antibodies against TIM3 and uses thereof

Номер: US12129297B2
Принадлежит: Bristol Myers Squibb Co

Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.

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