15-02-2018 дата публикации
Номер: US20180042844A1
Принадлежит:
The present technology provide compositions that are drug delivery systems for the sustained release of anti-stenotic drugs for the treatment and prevention of occlusion of blood vessels, particularly after perivascular surgery. The compositions include a hydrogel, unimolecular micelles dispersed within the hydrogel, and an effective amount of anti-stenotic drug dispersed within the unimolecular micelle. The hydrogel may be a di-or tri-block copolymer comprising one block of poly(ethylene glycol) (PEG) and one or two blocks of poly(lactic-co-glycolic acid) (PLGA). The unimolecular micelle may include three domains: a dendritic polymer core, hydrophobic block polymers (e.g., PVL, PVCL, and/or PCL) attached to the core and PEG attached to the hydrophobic block polymers. 1. A composition comprising a hydrogel , unimolecular micelles dispersed within the hydrogel , and an effective amount of anti-stenotic drug dispersed within the unimolecular micelles , whereinthe hydrogel is a di-or tri-block copolymer comprising one block of poly(ethylene glycol) (PEG) and one or two blocks of poly(lactic-co-glycolic acid) (PLGA), wherein the di- or tri-block copolymer has a molecular weight of about 1,500 to about 5,000 Da; a dendritic polymer having a molecular weight of 500 to 10,000 Da and terminating in hydroxyl, amino or carboxylic acid groups,', 'hydrophobic block polymers attached to at least a majority of the terminating groups of the dendritic polymer, wherein the hydrophobic block polymers have a molecular weight from about 1,000 to about 5,000 Da and which are selected from the group consisting of poly(valerolactone) (PVL), poly(valerolactone-co-lactic acid) (PVCL), and poly(caprolactone) (PCL), and', {'sub': '2', 'poly(ethylene glycol) attached to the hydrophobic block polymer and terminating in OH, O-alkyl, NH, or biotin, and having a molecular weight of about 1,000 to about 15,000 Da; and'}], 'the unimolecular micelle comprises'}the anti-stenotic drug is selected from ...
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