17-10-2013 дата публикации
Номер: US20130274254A1
The present application provides for a compound of formula I, and related compounds, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods that include the administration of such compounds with at least one additional therapeutic agent. 2. The compound of wherein:{'sup': 1', '1', '1', '1', '2, 'sub': 1', '6', '1', '6', '1', '6', '3', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '3', '6', '1', '6', '1', '6, 'Ais (C-C)alkyl, aryl(C-C)alkyl, heteroaryl(C-C)alkyl, (C-C)carbocyclyl(C-C)alkyl or heterocyclyl(C-C)alkyl, wherein any (C-C)alkyl of Ais optionally substituted with one or more Zgroups and wherein any aryl(C-C)alkyl, heteroaryl(C-C)alkyl, (C-C)carbocyclyl(C-C)alkyl or heterocyclyl(C-C)alkyl of Ais optionally substituted with one or more Zgroups;'}{'sup': 2', '2', '1', '2', '2', 'a', 'b', 'a1', 'b1', 'c', 'd', 'e, 'sub': 1', '6', '1', '6', '1', '6', '3', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '3', '6', '1', '6', '1', '6', '2, 'Ais (C-C)alkyl, aryl(C-C)alkyl, heteroaryl(C-C)alkyl, (C-C)carbocyclyl(C-C)alkyl or heterocyclyl(C-C)alkyl, wherein any (C-C)alkyl of Ais optionally substituted with one or more Zgroups and wherein any aryl(C-C)alkyl, heteroaryl(C-C)alkyl, (C-C)carbocyclyl(C-C)alkyl or heterocyclyl(C-C)alkyl of Ais optionally substituted with one or more Zgroups; X is —C(O)NRR, —C(O)NRR, —C(O)OR, —S(O)Ror —C(O)R;'}{'sup': 'f', 'Y is —C(O)O— or —C(O)NR—;'}{'sup': 1', '2', '2', '3', '2', '4', '1', '2', '5, 'sub': 1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6, 'Ris H or (C-C)alkyl, and Ris heterocyclyl(C-C)alkyl, awl, aryl(C-C)alkyl, heteroaryl(C-C)alkyl or (C-C)alkyl, wherein any heterocyclyl(C-C)alkyl, awl, aryl(C-C)alkyl or heteroaryl(C-C)alkyl of Ris optionally substituted with one or more Zgroups and wherein any (C-C)alkyl of Ris optionally ...
Подробнее
