HOCHAFFINE TELOMERASE-T-ZELLEN-REZEPTOREN

Exhaust line noise absorbing silencer for motor vehicle, has outer casing with blades, where silencer is made of synthetic rubber, and stainless steel tube assembled with olivary part and hook provided for fixation to motor vehicle

L'invention concerne un pot d'échappement pour moteurs à combustion interne deux ou quatre temps. Le pot d'échappement est entièrement réalisé en caoutchouc synthétique : Caoutchouc fluoré, bien connu par les fabricants des pneumatiques, caoutchouc siliconé pour une résistance supérieure à la chaleur ou similaire. Ce pot d'échappement(1) est insensible aux chocs mécaniques, peut être moulé d'une seule pièce, avec des formes multiples, avec l'insertion des lamelles (2) interposées verticalement en caoutchouc pour contrôler le niveau sonore. Les pots pourraient être assemblés avec des tubes (3) en acier inoxydable et des colliers de serrage (5). L'industrialisation d'un tel pot pourrait avoir un coût très inférieur aux pots classiques, le pot est insensible à la rouille et aux autres agressions climatiques, et peut être recyclé.

DEVICE TO REDUCE MAINLY the CARBON DIOXIDE PRODUCED BY ALL INTERNAL COMBUSTION ENGINES AND BY the ACTIVITY OF INDUSTRY

Dispositif pour réduire principalement le dioxyde de carbone produit par tous moteurs à combustion interne et par l'activité industrielle. L'invention concerne un dispositif composé d'un ensemble réservoir, pompe et un injecteur pour injecter directement dans le flux des gaz une solution de chaux hydratée avec d'éventuels adjuvants. Ce dispositif permet de diminuer fortement le rejet de dioxyde de carbone dans l'atmosphère et de réduire les risques du réchauffement de la planète. Device for primarily reducing the carbon dioxide produced by all internal combustion engines and by industrial activity. The invention relates to a device consisting of a reservoir assembly, pump and an injector for injecting directly into the flow of gases a solution of hydrated lime with optional adjuvants. This device greatly reduces the release of carbon dioxide into the atmosphere and reduces the risk of global warming.

Water heater for e.g. swimming pool, has opaque supply tube rolled spirally on cable drum for forming multidirectional bobbin capturing solar energy, where tube is connected to base of tank and channel, and enclosure in laminated glass

L'invention concerne un appareil autonome de chauffage d'eau (ou autre liquide) à énergie solaire par thermosiphon produit par effet de serre. Le réseau tubulaire de circulation du fluide est disposé en spirale à spires jointives multicouche, constituant une bobine (3). Cette bobine (3) installée en position verticale fixe devient un capteur multidirectionnel de l'énergie solaire. L'effet thermosiphon est optimalisé par une serre (4) en verre feuilleté coiffant la bobine(3). Cet appareil est particulièrement destiné au chauffage d'une piscine, d'un bassin d'eau (2) ou d'eaux de forage à utilisation domestique. La figure présente une vue en coupe du capteur et le bassin.

DEVICE TO IMPROVE the OUTPUT Of a CANDLE FOR INTERNAL COMBUSTION ENGINE, TWO OR FOUR TIMES

High affinity ny-eso t cell receptors

The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC SEQ ID NO:126 peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a K D for the said peptide-HLA complex of less than or equal to 1 μM and/or have an off-rate (k off ) of 1×10 −3 S −1 or slower.

Cells expressing modified t cell receptor

This invention provides a cell presenting at least one T cell receptor (TCR) anchored to the membrane by a trans-membrane sequence, said TCR comprising an interchain disulfide bond between extracellular constant domain residues which is not present in native TCRs.

Vector velocimeter

The present invention relates to a compact, reliable and low-cost vector velocimeter for example for determining velocities of particles suspended in a gas or fluid flow, or for determining velocity, displacement, rotation, or vibration of a solid surface, the vector velocimeter comprising a laser assembly for emission of a measurement beam for illumination of an object in a measurement volume with coherent light whereby a signal beam emanating from the object in the measurement volume is formed in response to illumination of the object by the measurement beam, a reference beam generator for generation of a reference beam, a detector system comprising a first detector arrangement arranged in such a way that the signal beam and the reference beam are incident upon the first detector arrangement with the reference beam propagating at an angle relative to a signal beam, and wherein the first detector array comprises a first detector array of first detector elements, each of the first detector elements converting the intensity of the interfering signal beam and reference beam incident thereupon into a corresponding electronic detector element signal thereby generating an oscillating electronic detector element signal when the fringe pattern formed by the interfering signal beam and reference beam moves across the first detector array; and a signal processor that is adapted for generation of a velocity signal corresponding to a first velocity component of movement of the object in the measurement volume in the longitudinal direction of the measurement volume based on the electronic detector element signals from each of the first detector elements.

Non-naturally occurring t cell receptors

A T cell receptor (TCR) having the property of binding to the gp100 YLEPGPVTA peptide-HLA-A2 complex and comprising a TCR alpha variable domain and/or a TCR beta variable domain, characterized in that the domains are mutated relative to a TCR having the extracellular alpha and beta chain sequences SEQ ID NOs: 2 and that the TCR has a binding affinity for, and/or a binding half-life for, the YLEPGPVTA-HLA-A2 complex at least double that of a reference TCR. Embodiments of the invention such as the use of such TCRs in adoptive therapy, and fusions of such TCRs with therapeutic agents are also described.

An infeed system for receiving and turning incoming food products prior to entering a processing machine

An infeed system is arranged for receiving and turning incoming food products before entering a processing machine. The food products are arranged so a longitudinal axis of the food products is essentially parallel to a conveying direction of the incoming food products. The system comprises a pair of conveyor structures having at least two side by side arranged endless belts extending from an infeed end of the infeed system to an outfeed end of the infeed system. The belts are twisted towards the outfeed end so at the outfeed end the conveyor structures are arranged side by side. At the infeed end, the incoming food products are received and clamped between the belts of the conveyor structures and advanced from the infeed end towards the outfeed end while simultaneously rotating the received food products around said longitudinal axis of the food products.

Detection of saxitoxin-producing dinoflagellates

The invention generally relates to the field of saxitoxins and the identification of microorganisms capable of producing them. More specifically, the invention relates to the identification of genes encoding saxitoxin in dinoflagellates, and methods for the specific detection of dinoflagellates that are producers of saxitoxins.

SYSTEM FOR AND METHOD OF SEPARATING OIL AND PARTICLES FROM PRODUCED WATER OR FRACTURING WATER

A system of separating oil and water from produced or fracturing water with an intended separation direction, the system includes: a unit for feeding the produced or fracturing water to a solid-fluid separator; a membrane system configured to output clean water; and a decanter configured to output solids, wherein the decanter or the membrane system is coupled to an output of the solid-fluid separator; wherein the membrane system or the decanter is configured to feed remaining fluid from the membrane system or decanter to an oil extractor system configured to output oil; and wherein the oil extractor system comprises a high speed separator configured to output the oil, and has a feedback conduit for feeding a remaining water containing fluid back to the membrane system. 1. A system of separating oil and water from produced or fracturing water with an intended separation direction , the system comprising:a unit for feeding the produced or fracturing water to a solid-fluid separator;a membrane system configured to output clean water; anda decanter configured to output solids, wherein the decanter or the membrane system is coupled to an output of the solid-fluid separator;wherein the membrane system or the decanter is configured to feed remaining fluid from the membrane system or decanter to an oil extractor system configured to output oil; andwherein the oil extractor system comprises a high speed separator configured to output the oil, and has a feedback conduit for feeding a remaining water containing fluid back to the membrane system.2. The system according to claim 1 , wherein the membrane system is coupled to a flushing system or a backward flush system.3. The system according to claim 2 , wherein the flushing system or the backward flush system is configured to flush or back-flush with a flushing agent.4. The system according to claim 2 , wherein the flushing or the backward flush system is configured to flush with pulses claim 2 , or back-flush with back-pulses. ...

Worm products and methods of use

The present invention relates to the use of a composition comprising a helminth product for prevention, treatment and/or amelioration of a clinical condition associated with the RIG-LISTING and TLR pathways. Specifically, the composition is provided for use in the treatment of clinical conditions associated with constitutive activation of type I interferon (IFN), including monogenic type I interferonopathies and inflammatory or autoimmune disorders. The present invention also relates to different methods of manufacturing a helminth product.

Method for predicting the off-target biding of a peptide which binds to a target peptide presented by a major histocompatibility complex

The invention provides a method for predicting whether a binding peptide, which binds to a target peptide presented by a Major Histocompatibility Complex (MHC) and is for administration to a subject, has the potential to cross react with another peptide in the subject in vivo. The method comprises the steps of identifying at least one binding motif in the target peptide to which the binding peptide binds; and searching for peptides that are present in the subject that comprise the at least one binding motif and that are not the target peptide. The presence of one or more such peptides indicates that the binding peptide has the potential to cross react in vivo.

Ion selective membranes and the preparation thereof

Processes for preparing ion selective membranes are presented which have selectivity for a primary analyte (in particular magnesium) as well as another ion (in particular calcium), wherein said process comprises addition of a) an ionophore (in particular 1,10-phenanthroline), b) a lipophilic salt containing said primary analyte (in particular hemi-magnesium bis[4-octylphenyl]phosphate) and c) a lipophilic salt containing said other ion (in particular hemi-calcium bis[4-octylphenyl]phosphate). Also, ion selective membranes are presented which are prepared using said processes, in particular to membranes selective for magnesium ions. In further aspects, electrodes and potentiometric sensors are presented comprising such membranes and the use thereof for determining ion concentrations in samples.

A System and a Method for Management of Confidential Data

A system and a method for managing confidential data in a cloud service is provided. The system comprises a cryptographic key service comprising two or more cryptographic key servers, S i , each being arranged to compute file encryption keys, k j , on the basis of information regarding data and using one or more cryptographic keys, K j . The cryptographic keys, K j , are secretly shared among the cryptographic key servers, S i , and none of the cryptographic key servers, S i , possesses knowledge of all of the cryptographic keys, K j . A single point of trust at the cryptographic key service is avoided.

Photonic crystal fiber, a method of production thereof and a supercontinuum light source

A Photonic Crystal Fiber (PCF) a method of its production and a supercontinuum light source comprising such PCF. The PCF has a longitudinal axis and includes a core extending along the length of said longitudinal axis and a cladding region surrounding the core. At least the cladding region includes a plurality of microstructures in the form of inclusions extending along the longitudinal axis of the PCF in at least a microstructured length section. In at least a degradation resistant length section of the microstructured length section the PCF includes hydrogen and/or deuterium. In at least the degradation resistant length section the PCF further includes a main coating surrounding the cladding region, which main coating is hermetic for the hydrogen and/or deuterium at a temperature below Th, wherein Th is at least about 50° C., preferably 50° C.<Th<250° C.

Window monitoring system

The invention relates to a window mounting system comprising: a building facade having an interior face and an exterior face and comprising a window opening; and a window mounting collar formed from rigid thermal insulating material, the mounting collar having at least one inside face, at least one outside face, a first open end and a second open end; wherein the window mounting collar is affixed to the exterior face of the building facade so as to surround the window opening and extend outwards from the exterior face of the facade, such that the first end of the mounting collar is proximal to the building facade and the second end of the mounting collar is distal from the building facade; wherein the system further comprises a window frame arranged in the mounting collar such that the window frame is separated from the plane of the exterior face of the building facade by at least 10 mm.

Tcr libraries

The present invention relates to a library of particles, the library displaying a plurality of different T cell receptors (TCRs), wherein the plurality of TCRs consists essentially of TCRs comprising an alpha chain variable domain and a beta chain variable domain, wherein the alpha chain variable domain comprises a TRAV27 gene product and the beta chain variable domain comprises a TRBV9 gene product.

Nicotine pouch product

A nicotine pouched product is disclosed, the nicotine pouched product having a pouch composition and a pouch membrane enclosing the pouch composition, the pouch composition including at least one water-insoluble fiber, water in an amount of at least 15% by weight of the composition, and nicotine, wherein the pouch membrane comprises further nicotine in an amount of at least 15% by weight of a total content of nicotine in the pouched product.

A touch-sensitive device

The present invention relates to an optical touch-sensitive device and a method of determining a position and determining a position change of an object contacting an optical touch sensitive device. In particular, the present invention relates to an optical touch pad and a method of determining a position and determining a position change of an object contacting an optical touch pad. A touch-sensitive device, according to the present invention may comprise a light source, a touch- sensitive waveguide, a detector array, and a first light redirecting member, wherein at least a part of the light propagating towards a specific point of the detector array is prevented from being incident upon the specific point of the detector array when an object contacts a touch-sensitive surface of the touch-sensitive waveguide at a corresponding specific contact point.

Systems for analysis of biological materials

The present invention features methods for self-learning, self-engineering microarrays for the analysis of complex mixtures of nucleic acids and systems and apparatuses embodying such methods. Inmore particular aspects, the present invention features mathods and systems that include imputting data relating to one or more biomolecules into a database; indentifying at least one of a plurality of groupings for data to be obtained (mined) from the universal database; inputting at least one of the groupings into a neutral network program, which can analyze the data and generate new design rules for predicting biological data; and adapting a software program including initial design rules to the new design rules.

Single chain recombinant t cell receptors

A single chain T cell receptor (scTCR) comprising an a segment constituted by a TCR α chain variable region sequence fused to the N terminus of a TCR α chain constant region extracellular sequence, a β segment constituted by a TCR β chain variable region fused to the N terminus of a TCR β chain constant region extracellular sequence, and a linker sequence linking the C terminus of the α segment to the N terminus of the β segment, or vice versa, the constant region extracellular sequences of the αand β segments being linked by a disulfide bond, the length of the linker sequence and the position of the disulfide bond being such that the variable region sequences of the α and β segments are mutually orientated substantially as in native αβ T cell receptors. Complexes of two or more such scTCRs, and use of the scTCRs in therapy and in various screening applications are also disclosed.

Modified soluble t cell receptor

The present invention provides a soluble T cell receptor (sTCR), which comprises (i) all or part of a TCR &dollar;g(a) chain, except the transmembrane domain thereof, and (ii) all or part of a TCR &dollar;g(b) chain, except the transmembrane domain thereof. (i) and (ii) each comprise a functional variable domain and at least a part of the constant domain of the TCR chain, and are linked by a disulphide bond between constant domain residues which is not present in native TCR, characterised in that the sTCR recognises a CD1-antigen complex, a bacterial superantigen or a peptide-MHC/superantigen complex.

Delivery date simulation and control

A method and system for determining a merchant ship date and a corresponding customer receipt date when processing an order in an ERP system. The method includes accessing a delivery date simulation form stored in the ERP system during processing of the new order and changing an existing order. The method includes generating a list of alternative merchant ship dates and corresponding customer receipt dates to be displayed on the delivery date simulation form. The list of merchant ship dates and customer receipt dates are calculated based at least partially on customer parameters and at least partially on merchant parameters stored in a database of the ERP system. The method also includes transferring a selected merchant ship date and corresponding customer receipt date from the list of alternative merchant ship dates and corresponding customer receipt dates to the order.

Bread-improving additive comprising a xylanolytic enzyme

The present invention relates to bread-improving additives. More specifically, the invention relates to bread-improving additives comprising xylanolytic enzymes derived from strains of Thermomyces lanuginosus, to methods for preparing baked products, and to methods for improving the baking properties of flour or dough.

Recovery process

Disclosed is a method for recovering a desired fermentation product from a fermentation broth where the desired product has precipitated during the fermentation.

Touch-sensitive device

【課題】低コストで製造することができる接触感応装置を提供する。 【解決手段】接触感応装置２は、光源４と、接触感応導波路８と、検出器アレイ２０と、第１の光方向転換部材１４とを備える。検出器アレイ２０の特定の位置に向かって伝搬する光の少なくとも一部が、対象物が対応する特定の接触点で接触感応導波路８の接触感応面に接触している場合は、検出器アレイ２０の特定の位置に入射するのを妨げる。 【選択図】図１

An encoding device and a method of encoding

The present invention relates to an encoding device, such as an optical position encoder, for encoding input from an object, and a method for encoding input from an object, for determining a position of an object that interferes with light of the device. The encoding device comprises a light source, a waveguide, a number of redirecting structures, and a detector. By means of the waveguide and the number of redirecting structures, light from the light source is guided towards the detector along a path that includes traversing an area in a space next to the planar waveguide. An object may be positioned in the area in the space and may interfere with the light, which interference may be encoded into a position or activation.

Device and method for detecting presence of an object

Method for predicting the off-target biding of a peptide which binds to a target peptide presented by a major histocompatibility complex

The invention provides a method for predicting whether a binding peptide, which binds to a target peptide presented by a Major Histocompatibility Complex (MHC) and is for administration to a subject, has the potential to cross react with another peptide in the subject in vivo. The method comprises the steps of identifying at least one binding motif in the target peptide to which the binding peptide binds; and searching for peptides that are present in the subject that comprise the at least one binding motif and that are not the target peptide. The presence of one or more such peptides indicates that the binding peptide has the potential to cross react in vivo.

Method for predicting the off-target biding of a peptide which binds to a target peptide presented by a major histocompatibility complex

The invention provides a method for predicting whether a binding peptide, which binds to a target peptide presented by a Major Histocompatibility Complex (MHC) and is for administration to a subject, has the potential to cross react with another peptide in the subject in vivo. The method comprises the steps of identifying at least one binding motif in the target peptide to which the binding peptide binds; and searching for peptides that are present in the subject that comprise the at least one binding motif and that are not the target peptide. The presence of one or more such peptides indicates that the binding peptide has the potential to cross react in vivo.

Method for predicting the off-target biding of a peptide which binds to a target peptide presented by a major histocompatibility complex

The invention provides a method for predicting whether a binding peptide, which binds to a target peptide presented by a Major Histocompatibility Complex (MHC) and is for administration to a subject, has the potential to cross react with another peptide in the subject in vivo. The method comprises the steps of identifying at least one binding motif in the target peptide to which the binding peptide binds; and searching for peptides that are present in the subject that comprise the at least one binding motif and that are not the target peptide. The presence of one or more such peptides indicates that the binding peptide has the potential to cross react in vivo.

Method of manufacturing a fibre reinforced composite component having a reinforced hole

The invention relates to a method of manufacturing a composite component with continuous fibre reinforcement and having a reinforced hole. The hole is reinforced by incorporation of at least one reinforcing element (1) into a layered arrangement of continuous fibres. The reinforcing element comprises a circumferential member (2) with a through-going first hole (9) and a plurality of continuous element fibres (3). The at least one reinforcing element (1) is arranged in an overlapping and/or sandwiching engagement with the layered arrangement so that the first hole is arranged within and aligned with a second hole (8) to be reinforced. Hereby an externally force applied to the reinforced hole during use of the component is distributed over a larger region of the material around the hole. Thereby the component can be joined to another part e.g. by a bolted connection which allows for disassembly that would not have been possible if they were joined by adhesive joining.

Inactivation of a production strain using a fatty acid

A method of inactivating the microbial host cell in a fermentation broth comprising an enzyme of interest and the microbial host cell producing the enzyme of interest comprising: a) Adding a fatty acid having a chain length of C4-C12 to the fermentation broth; and b) Mixing the fermentation broth for a sufficient period of time until the microbial host cell is inactivated.

Compositions comprising extracellular vesicles and sting stimulatory agents

This present invention describes extracellular vesicles derived from activated T cells can prime macrophages for enhanced pro-inflammatory response towards stimulation with STING agonists. Further, a direct anti-tumoral effect of extracellular vesicles derived from activated T cells prior to intratumorally injection of cGAMP is demonstrated.

Dose logging device for a drug delivery device

A system comprising a sensor assembly adapted to measure a magnetic field, and a mechanical assembly comprising an indicator element with a magnet moving together therewith, the magnet being configured to generate a spatial magnetic field which relative to the sensor assembly varies corresponding to the spatial position and orientation of the magnet, wherein the indicator element is adapted to both rotate and move axially during operation of the assembly. Processor means is configured to determine on the basis of measured values both a rotational position and an axial position of the indicator element.

Medical delivery system comprising locking ring with L-shaped grooves

A medical delivery system comprising a container which is adapted to be fastened to a dosing assembly. One of the container and the dosing assembly comprises a rotatable element adapted to cooperate with the other one of the container and the dosing assembly, so as to lock/fasten the container to the dosing assembly. Furthermore, the present invention relates to a container and a dosing assembly for use in the medical delivery system.

Medical Delivery System Adapted to be Locked Axially and Unlocked Rotationally

A medical delivery system ( 100 ) comprising a dosing assembly ( 104 ) and a container ( 102 ), wherein the container ( 102 ) is adapted to be locked to the dosing assembly ( 104 ) through a pure translational movement and unlocked from the dosing assembly ( 104 ) through a pure rotational movement. A dosing assembly ( 104 ) and a container ( 152 ) suitable for use in the medical delivery system ( 150 ).

Medical Delivery System Comprising a Coding Mechanism Between Dosing Assembly and Medicament Container

A medical delivery system comprising a container for accommodation of a medicament and a dosing assembly adapted to be fastened to the container. The medical delivery system comprises a coding mechanism ( 150, 152 ) for ensuring that only a predetermined container can be fastened to a predetermined dosing assembly. The coding mechanism comprises axially extending protrusions ( 154, 156, 158 ) arranged at the interface between container and dosing assembly and arranged in a ring configuration concentric with a proximal rim portion of the container. A container for use in the medical delivery system. A dosing assembly for use in the medical delivery system.

Medical Delivery System Comprising Locking Ring with L-Shaped Grooves

A medical delivery system ( 100 ) comprising a container ( 102 ) which is adapted to be fastened to a dosing assembly ( 104 ). One of the container and the dosing assembly comprises a rotatable element ( 106 ) adapted to cooperate with the other one of the container and the dosing assembly, so as to lock/fasten the container to the dosing assembly. Furthermore, the present application relates to a container and a dosing assembly for use in the medical delivery system.

Syringe device

A medical delivery system comprising a container and a coupling mechanism movable between a coupling position wherein distal movement of a drive mechanism is transferred to an actuator, and a non-coupling position wherein distal movement is not transferred to the actuator. Moreover the present invention relates to a dosing assembly for use in the medical delivery system and a container for use in the medical delivery system. Finally, the present invention relates to medical delivery system comprising a dosing assembly having means for preventing a drive stem of the dosing assembly from being moved in a distal direction.

Drug delivery device and logging module assembly

A drug delivery assembly comprises a drug delivery device, an electronic dose logging module releasably attachable to the drug delivery device, and a cap releasably attachable to the logging module to cover an outlet portion of a mounted drug reservoir. The logging module and the drug delivery device comprise mating snap coupling means. The logging module comprises locking means acting on the locking module snap coupling means, wherein the locking means is actuated from the unlocked to the locked state when the cap is attached to the logging module in a first direction, and the locking means is actuated from the locked to the unlocked state when the cap is detached from the logging module in a second direction opposed to the first direction.

Drug injection device with switch arrangement

A drug injection device (1) comprising: a housing portion (2) extending along a central longitudinal axis, an activation element (60, 70) configured to undergo rotational movement around the axis corresponding to one of a dose setting action and a dose expelling action, the activation element (60, 70) comprising at least one protrusion (60.0, 60.1, 70.1) extend- ing radially outwards, a switch arrangement (100) configured as a multi-layer substrate having a dimension extending in parallel with the central longitudinal axis, and comprising: a first flexible sheet (100.1) having a radially outwards facing surface that includes a first electrode carrying surface portion, and a second sheet (100.2) arranged in general parallelism with the first sheet (100.1), the second sheet (100.2) having a radially inwards facing surface opposing the radially outwards facing surface of the first sheet (100.1), the radially inwards facing surface including a second electrode carrying surface portion and defining one or more pair(s) of switch electrodes (160.1, 160.2, 160.3, 170.1), wherein each one or more pairs of switch electrodes of the switch arrangement (100) is configured to assume an inactive state where the first and the second electrode carrying surface portions are spaced apart and an active state where the first and the second electrode carrying surface portions are in contact, and wherein when one of said at least one protrusion (60.0, 60.1, 70.1) assumes an activating position it acts on the first sheet (100.1) to deflect the first electrode carrying surface portion located at the respective pair of switch electrodes (160.1, 160.2, 160.3, 170.1) into con- tact with the second electrode carrying surface portion.

Medical delivery system comprising locking ring with L-shaped grooves

A medical delivery system ( 100 ) comprising a container ( 102 ) which is adapted to be fastened to a dosing assembly ( 104 ). One of the container and the dosing assembly comprises a rotatable element ( 106 ) adapted to cooperate with the other one of the container and the dosing assembly, so as to lock/fasten the container to the dosing assembly. Furthermore, the present application relates to a container and a dosing assembly for use in the medical delivery system.

Therapeutic uses of lna-modified oligonucleotides

The invention relates to therapeutic applications of LNA-modified oligonucleotides. In particular, the invention provides methods for treatment of undesired cell growth as well as treatment of inflammatory related diseases and disorders. Preferably, administration of an LNA-modified oligonucleotide modulates expression of a targeted gene associated with the undesired cell growth or an inflammatory related disease or disorder.

Single chain recombinant T cell receptors

A single chain T cell receptor (scTCR) comprising an a segment constituted by a TCR α chain variable region sequence fused to the N terminus of a TCR α chain constant region extracellular sequence, a β segment constituted by a TCR β chain variable region fused to the N terminus of a TCR β chain constant region extracellular sequence, and a linker sequence linking the C terminus of the α segment to the N terminus of the β segment, or vice versa, the constant region extracellular sequences of the α and β segments being linked by a disulfide bond, the length of the linker sequence and the position of the disulfide bond being such that the variable region sequences of the α and β segments are mutually orientated substantially as in native αβ T cell receptors. Complexes of two or more such scTCRs, and use of the scTCRs in therapy and in various screening applications are also disclosed.

Receptors

A multivalent T cell receptor (TCR) complex comprising at least two TCRs, linked by a non-peptidic polymer chain or a peptidic linker sequence. Preferably the TCR complex comprises TCR heterodimers having a non-native disulfide bond between constant domain residues, said TCRs being linked via an optionally substituted, polyalkylene glycol linker. Therapeutic agents such as cytotoxic drugs may be attached to such complexes for targeted cell delivery. Such TCR complexes may be used in the diagnosis or treatment of cancer, infectious disease, or autoimmune disease.

High affinity NY-ESO T cell receptor

Disclosed is a T-cell receptor (TCR) having the property of binding to SLLMWlTQC-HLA-A*0201 and comprising at least one TCR a chain variable domain and/or at least one TCR beta-chain variable domain characterised in that said TCR (i) is mutated relative to the native 104 TCR alpha chain variable domain (SEQ 10 No: 1) and/or beta-chain variable domain (SEQ 10 NO: 2) in at least one complementarity determining region or in at least one variable domain framework region thereof, and (ii) has a KD for the said SLLMWlTQC-HLA-A*0201 complex of less than or equal to 1microM and/or has an off-rate (koff) for the SLLMWlTQC-HLA-A*0201 complex of 1x10-3 S-1 or slower. Also disclosed is the use of the TCR described above in the treatment of cancer.

T-cell receptors containing a non-native disulfide interchain bond linked to therapeutic agents.

La presente invencion proporciona un TCR dimerico (dTCR) o TCR de cadena sencilla (scTCR) asociado con agentes terapeuticos seleccionados, en donde los TCR comprenden un primer segmento constituido por una secuencia de aminoacido correspondiente a una secuencia de dominio variable de cadena TCR a fusionado a la terminal N de una secuencia de aminoacido correspondiente a la secuencia extracelular de dominio constante de cadena TCR a, un segundo segmento constituido por una secuencia de aminoacido correspondiente a un dominio variable de cadena TCR ?? fusionado a la terminal N de una secuencia de aminoacido correspondiente a la secuencia extracelular de dominio constante de cadena TCR ??, un enlace disulfuro entre la primera y segunda cadena, el enlace disulfuro es uno en los cuales no hay equivalente en los receptores de celulas T ?? nativos y en el caso del scTCRs ademas comprende una secuencia ligadora enlazada a la terminal C del primer segmento a la terminal n del segundo segmento, o viceversa, la longitud de la secuencia ligada y la posicion del enlace disulfuro es tal que la secuencia de dominio variable del primer y segundo segmentos se orientan mutuamente substancialmente como en receptores de celulas T ?? nativos.

Soluble Bifunctional Proteins

The present invention provides a soluble bifunctional protein comprising an association between a T cell receptor and a superantigen. Also provided are therapeutic compositions comprising said bifunctional proteins and methods for the use thereof.

Open substrate platforms suitable for analysis of biomolecules

The invention relates to novel analysis slides or substrates of the open configuration. The slides may be used for any application which normally utilizes a conventional microscope slide and can be used in conjunction with any type of equipment typically used to manipulate or evaluate a standard microscope slide. In particular, the invention provides open slides for covalent immobilization of polypeptides and nucleic acids. Further provided are methods for carrying out biological assays using arrays of biomolecules immobilized on the slides of the invention.

Closed substrate platforms suitable for analysis of biomolecules

The invention relates to a closed substrate platform comprising: a container comprising an area for sample analysis and a microfluidic analysis platform, the container comprising (i) at least one inlet for the introduction of fluid to the sample analysis area and (ii) an outlet for removal of fluid to the sample analysis area; and a vent for expulsion of air from the container. The substrate platform may be used for covalent immobilization of polypeptides and nucleic acids and may be used in conjunction with any type of equipment typically used to manipulate or evaluate a standard microscope slide, such as a scanner.

CD8 as an inhibitor of the cellular immune system

Nicotine pouch product

A nicotine pouched product is disclosed, the nicotine pouched product having a pouch composition and a pouch membrane enclosing the pouch composition, the pouch composition including at least one water-insoluble fiber, water in an amount of at least 15% by weight of the composition, and nicotine, wherein the pouch membrane comprises further nicotine in an amount of at least 15% by weight of a total content of nicotine in the pouched product.

T cell receptor display

Oral product in bag

Un producto oral en bolsa que comprende una bolsa permeable a la saliva, una composición de la bolsa sin tabaco, la composición de la bolsa que comprende - fibras tratadas térmicamente, - nicotina en una cantidad de 0,1-5,0 % en peso de la composición, - agua en una cantidad del 20-65 % en peso de la composición de la bolsa, y - al menos un alcohol de azúcar en una cantidad del 10-60 % en peso de la composición de la bolsa, en donde al menos un alcohol de azúcar se selecciona de xilitol, maltitol, manitol, eritritol, isomalt, sorbitol, lactitol y las mezclas de los mismos, y - conservante en una cantidad de entre 0,05 y 0,5 % en peso de la composición. An oral pouch product comprising a saliva-permeable pouch, a tobacco-free pouch composition, the pouch composition comprising - heat-treated fibers, - nicotine in an amount of 0.1-5.0% by weight of the composition, - water in an amount of 20-65% by weight of the composition of the bag, and - at least one sugar alcohol in an amount of 10-60% by weight of the composition of the bag, where at least one sugar alcohol is selected from xylitol, maltitol, mannitol, erythritol, isomalt, sorbitol, lactitol and mixtures thereof, and - preservative in an amount between 0.05 and 0.5% by weight of the composition .

Tapered optical fiber for supercontinuum generation

The invention relates to a tapered optical fiber and a method and drawing tower for producing such an optical fiber. The tapered optical fiber comprising a core region that is capable of guiding light along a longitudinal axis of said optical fiber and a cladding region surrounding said core region. The optical fiber comprises a tapered section arranged between a first longitudinal position and a second longitudinal position, said tapered section comprising a first taper section having a first length, L1, over which the optical fiber is tapered down to a taper waist, and a second taper section having a second length, L2, over which said optical fiber is tapered up.

Multivalent soluble T cell receptor (TCR) complexes

Described are soluble T cell receptors which comprises (i) at least a part of TCR alpha chain, except the transmembrane domain thereof, and (ii)at least a part of the TCR beta chain, except the transmembrane domain. Each of (i) and (ii) comprise a functional variable domain and at least part of the constant domain if the TCR chain and are linked by a disulphide bond by substituted cysteine residues which are not present in native TCR. Also described are methods of detecting MHC-peptide complexes, obtaining a soluble T cell receptor and pharmaceutical compositions comprising soluble TCR or a multivalent TCR complex.

An element for a preform, a fiber production method and an optical fiber drawn from the preform

A preform element, it production and fiber production methods from preform assemblies are disclosed. The preform element has a length and a center axis along its length, a first and second end defined by its length and an outer preform element surface. The preform element comprises a plurality of longitudinal structures disposed to form longitudinal hole(s) in a background material. At least one slot extending from its outer preform element surface and intersecting at least one of the longitudinal holes, wherein the at least one slot does not fully intersect the preform element. The preform element may be a preform center element or a preform ring element and may be assembled to a form part of a preform assembly for an optical fiber.

An insulating roof support assembly, a method of installing such roof support assembly and an insulating roof construction

Device and method for detecting presence of an object

The present invention relates to a method (60) and device (2, 40, 50) for detecting presence of an object (52) by means of influencing propagation of light (16) arriving to a detector (14). The device (2, 40, 50) for detecting presence of the object (52) at the device (2, 40, 50) comprises a light source (4), a first redirecting structure (6), a second redirecting structure (10), and a light detector device (14). The light source (4) is adapted to emit light (16) towards the first redirecting structure (6), which is adapted to redirect light (16) from the light source (4) towards the second redirecting structure (10), which is adapted to return light (16) from the first redirecting structure (6) back towards the first redirecting structure (6), which is adapted to redirect light (16) from the second redirecting structure (10) towards the light detector device (14). The device (2, 40, 50) has a sensing zone (18) formed by light (16) propagating between the first redirecting structure (6) and the second redirecting structure (10).

Unloading device

A touch-sensitive device

The present invention relates to an optical touch-sensitive device and a method of determining a position and determining a position change of an object contacting an optical touch sensitive device. In particular, the present invention relates to an optical touch pad and a method of determining a position and determining a position change of an object contacting an optical touch pad. A touch-sensitive device, according to the present invention may comprise a light source, a touch- sensitive waveguide, a detector array, and a first light redirecting member, wherein at least a part of the light propagating towards a specific point of the detector array is prevented from being incident upon the specific point of the detector array when an object contacts a touch-sensitive surface of the touch-sensitive waveguide at a corresponding specific contact point.

High affinity hiv t cell receptors

The present invention provides TCRs having an affinity (KD) of less than or equal to l~M, and/or an off-rate (koff) of 1x10-3 S-1 or slower, for the SLYNTVATL-HLA- A* 0201 complex PROVIDED THAT when the said TCR is presented by cell and comprises SEQ ID NOs: 1 and 2, the cell is not a native T cell. Such TCRs are useful, either alone or associated with a therapeutic agent, for targeting HIV infected cells presenting that complex.

Hollow core optical fiber and a laser system

A hollow core photonic crystal fiber (PCF) comprising an outer cladding region and 7 hollow tubes surrounded by the outer cladding region. Each of the hollow tubes is fused to the outer cladding to form a ring defining an inner cladding region and a hollow core region surrounded by the inner cladding region. The hollow tubes are not touching each other, but are arranged with distance to adjacent hollow tubes. The hollow tubes each have an average outer diameter d2 and an average inner diameter d1, wherein d1/d2 is equal to or larger than about 0.8, such as equal to or larger than about 0.85, such as equal to or larger than about 0.9. Also a laser system is disclosed.

T SOLUBLE CELL RECEIVER.

Un receptor de células T (TCR) recombinante replegado que comprende: i) un dominio extracelular de la cadena o de TCR recombinante que tiene un primer péptido de dimerización C-terminal heterólogo; y ii) un dominio extracelular de la cadena a o de TCR recombinante que tiene un segundo péptido de dimerización C-terminal que se heterodimeriza específicamente con el primer péptido de dimerización para formar un dominio de heterodimerización, en el que está ausente un enlace de disulfuro presente en TCRs naturales entre las cadenas y a o y adyacentes al dominio citoplásmico. A folded recombinant T-cell receptor (TCR) comprising: i) a recombinant chain or TCR extracellular domain having a first heterologous C-terminal dimerization peptide; and ii) an extracellular domain of the ao chain of recombinant TCR having a second C-terminal dimerization peptide that specifically heterodimerizes with the first dimerization peptide to form a heterodimerization domain, in which a disulfide bond is absent present in natural TCRs between the yaoy chains adjacent to the cytoplasmic domain.

CD8alpha mutants

The present invention provides modified CD8 molecules whose binding to MHC is enhanced compared to wild-type CD8, wherein Ser 53 of at least one CD8α chain thereof is mutated to another amino acid. It also provides nucleic acids encoding such molecules and methods of using such molecules and nucleic acids in immunosuppressive therapy, in particular as inhibitors of cytotoxic T cell responses.

Device, a system and a method of encoding a position of an object

The present invention relates to a device for encoding a position of an object, comprising a first light source; a first collimating element adapted to form first collimated light from the first light source; a carrier adapted to guide light and comprising a first primary light redirecting structure and a second primary light redirecting structure; and a detector device for encoding the position of an object with respect to an active area of an encoding plane; wherein the first primary light redirecting structure is adapted to redirect at least a part of a first light beam through the active area into the second primary light redirecting structure; and wherein the second primary light redirecting structure is adapted to redirect light received from the first primary light redirecting structure onto the detector device. Thereby is achieved that a collimated light beam is propagated along the carrier and from the carrier into the active area via the first primary light redirecting means. The collimated light ensures a controlled part of the carrier is utilized for the propagation of the collimated light.

Window mounting system

DERRICK

A derrick (1) for drilling and maintenance of oil and/or gas wells comprises a portal-shaped derrick structure installed on the drilling deck, consisting of an upper traverse (2) and two spaced-apart, substantially parallel, upright derrick components (3,4) which together define a free space (5), within which a hydraulic elevator (6) connected to a drilling machine (18) for the drill string (15) is adapted to travel along stationary, upright rack rails (10). The vertically movable elevator (6), in a manner known per se, is driven by means of hydraulic motors having gears (9) that engage with the rack rails (10).

A pen-shaped torsion spring driven injection device

The invention relates to a pen-shaped torsion spring driven injection device for apportioning set dose of a liquid drug. A piston rod having an external thread is driven forward by a rotatable piston rod guide engaging the piston rod. The piston rod guide is rotated by a torsion spring encompassed between the housing and the piston rod guide. A scale drum having a thread engaging the external thread of the piston rod is provided, and the scale drum is rotated up and down the piston rod by a proximal located rotatable dose setting member cooperating with the scale drum. The scale drum thus move helically when rotated as the piston rod is held inrotatable during dose setting.

Fabrication of microstructured fibres

A trimming system for trimming fish

A trimming system for fish which is placed with belly sides on opposite sides of a supporting structure. A force supplying means applies opposite forces onto the belly sides towards the supporting structure. A profile measuring means determines the profile of the belly sides, and a cutting means trims the belly sides. Opposite forces are supplied by the force supplying means while the belly sides are measured by the profile measuring means, and the opposite forces are supplied while the belly sides are simultaneously trimmed.

Insulation system for covering a facade of a building

This invention relates to an improved insulation system for covering a facade of a building consisting of at least one insulation element (3), at least one mechanical fastener (4), which fastener fixes the insulation element (3) to the facade (2) of the building, and a rendering system (5) being arranged on the outer surface of the insulation element (3) whereby the insulation element has at least a first and a second layer being connected to each other; whereby the first layer being directed to the facade having a bulk density being lower than the bulk density of the second layer and whereby at least one layer is made of mineral fibres, especially stone wool fibres and a binding agent, or of cellular plastic, especially expanded polystyrene (EPS). To achieve an insulation system which has very good insulation characteristics, which can be produced for low costs and which can be fixed to the facade of a building without causing high labour costs the insulation element (3) has a third layer (10) made of mineral fibres and a binding agent, which third layer (10) has a bulk density being higher than the bulk density of the second layer (9) and which third layer (10) has a high receptiveness and/or adhesion for the rendering system (5) without using any surface primer, coating and/or an additive.

Stacks.

High affinity NY-ESO T cell receptor

The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a K for the said that peptide-HLA complex of less than or equal to 1µM and/or have an off-rate (k) of 1x10 S or slower.

An infeed system for receiving and turning incoming food products prior to entering a processing machine

This invention relates to an infeed system (100) for receiving and turning incoming food products, in particular de-headed fish, prior to entering a processing machine, where the food products are arranged such that a longitudinal axis of the food products is essentially parallel to a conveying direction of the incoming food products, comprising: - a pair of conveyor structures (101, 102), where the pair of conveyor structures comprises at least two side by side arranged endless belts (103, 104) extending from an infeed end (106) of the infeed system to an outfeed end (107) of the infeed system, where, at the infeed end, the conveyor structures are arranged above and below each other, and where the belts are twisted towards the outfeed end such that at the outfeed end the conveyor structures are arranged side by side, - a driving unit (111a,b) for driving the conveyor structures in opposite rotational directions such that adjacent sides of the conveyor structures are moving in the same direction (108, 109) from the infeed end towards the outfeed end, wherein at the infeed end the incoming food products are received and clamped between the belts of the conveyor structures and advanced from the infeed end towards the outfeed end while simultaneously rotating the received food products around said longitudinal axis of the food products.

METHOD FOR FOLDING A CIRCULAR LID ON A CAN BODY

Method

The present invention provides a method for identifying an entity which binds to a peptide-Major Histocompatibility Complex (pMHC) complex. In the method, a pMHC complex is formed between a predetermined MHC and a peptide which is obtained from a protein sequence and is not known to be capable of being complexed with the predetermined MHC. The resulting pMHC is used to screen for an entity which binds to the pMHC complex.

Method for photochemical immobilization of ligands using quinones

Insulation system for covering a facade of a building

This invention relates to an improved insulation system for covering a facade of a building consisting of at least one insulation element (3), at least one mechanical fastener (4), which fastener fixes the insulation element (3) to the facade (2) of the building, whereby the insulation element has at least a first (8) and a second layer (9), the first layer (8) being directed to the facade (2) having a bulk density being lower than the bulk density of the second layer (9), whereby at least one layer is made of mineral fibres, especially stone wool fibres and a binding agent and whereby the fastener (2) has a shaft (11) erecting through the insulation element (3) into the building and a plug-plate (12) being arranged on or in the outer surface (35) of the insulation element (3). To achieve an insulation system which has very good insulation characteristics, which can be produced for low costs and which can be fixed to the facade of a building without causing high labour costs the shaft (11) if the fastener (4) partly erects into the first layer (8) of the insulation element (3) in a direction parallel to the surface of the facade (2).

Single chain recombinant t cell receptors

Auxiliary component for a medical visualisation device

Disclosed is an auxiliary component and a medical visualisation device comprising a main device part and the auxiliary component. The auxiliary component being couplable to the main device part to form a medical visualisation device. The main device part comprises an image sensor adapted to generate image data indicative of a view from the main device part, a light emitter adapted to 5provide illumination of the view, and a main coupling part having one or more main terminals electrically connected to the light emitter and the image sensor. The auxiliary component comprising a device wireless communication module adapted to communicate with a monitor wireless communication module of a monitor device, the device wireless communication module being adapted to transmit encoded image data using a downstream data channel to the monitor wireless 0communication module.

Porous unit without reflective layer for optical analyte measurements

There is presented a porous unit (1) for detection of an analyte (96) in a liquid (99) by optical probing, comprising a translucent element (2) with a front side (3), and a backside (4) facing away from the front side (3), wherein the front side (3) is adapted for being contacted directly with the liquid (99), or separated from the liquid (99), such as exclusively separated from the liquid (99), by one or more layers at the front side (3) of the translucent element (2), the one or more layers (5) being adapted to be non-reflective to light reaching the one or more layers at least at one angle of incidence, such as at least at normal incidence, from the translucent element (2), and/or allow internal reflection, such as total internal reflection, at an interface, such as an external interface, of light reaching the interface from the translucent element (2), wherein the translucent element (2) comprises pores (6), wherein the pores (6) are dead end pores (6) extending from respective openings (7) fluidically connecting them with the liquid (99) at the front side (3) into the translucent element (2), wherein a cross-sectional dimension of the openings (7) of the pores (6) is dimensioned so as to prevent larger particles or debris from entering the pores (6), while allowing the analyte in the liquid (99) to enter the pores (6) via diffusion.

Non-tobacco oral nicotine pouch composition

A non-tobacco oral nicotine pouch composition is disclosed, the pouch composition comprising water in an amount of at least 15 % by weight of the pouch composition, nicotine, and at least one sugar alcohol, wherein the pouch composition is free of humectants consisting of alginate, propylene glycol, hydroxypropyl cellulose and glycerol. Also, an oral pouched nicotine product is disclosed.

An insulating roof support assembly, a method of installing such roof support assembly and an insulating roof construction

The present invention concerns an insulating roof support assembly for a roof structure comprising a plurality roof elongated rafters spaced apart in a predetermined distance with insulation boards therebetween, wherein elongated mineral wool fibre insulation elements are provided on the top of each of the elongated roof rafters and elongated wooden elements on top of said insulation elements with at least one impermeable membrane between at least two neighbouring insulation elements sandwiched between the wooden elements and the insulation elements.

Fish farm and associated systems and methods

A fish farm (100) comprising an enclosure (1) for fish configured to be arranged in a body of water (2), the enclosure (1) being rotatable about a substantially horizontal axis (3). A fish farm (100) comprising an enclosure (1) for fish configured to be arranged in a body of water (2), the enclosure (1) being rotatable about a substantially horizontal axis (3).

Semi-submersible fish farming system

Present invention relates to a semisubmersible fish-faring system, comprising: a ring-shaped or polygonal lower buoyancy member (7), a ring- shaped or polygonal upper buoyancy member (9) and a plurality of pillars (8) connecting the buoyancy member (8, 9), and a fish pen (3) connected to the lower buoyancy member (7), and a net roof (5) closing off the top of the fish pen (3),said system can be located in at least two different submerged positions by ballasting/deballasting, a first position (service position) (15) where the system is floating on the lower buoyancy member (7) and the pillars (8) and upper buoyancy member (9) is above the water surface, and a second, operational position (16), where the lower buoyancy member (7) and the major parts or all the extension of the pillars (8) is below the water surface. The present invention relates to a semisubmersible fish-faring system comprising: a ring-shaped or polygonal lower buoyancy member (7), a ring-shaped or polygonal upper buoyancy member (9) and a plurality of pillars (8) connecting the buoyancy member (8, 9), and a fish pen (3) connected to the lower buoyancy member (7), and a net roof (5) closing off the top of the fish pen (3), said system can be located in at least two different submerged positions by ballasting / deballasting, a first position (service position) (15) where the system is floating on the lower buoyancy member (7) and the pillars (8) and upper buoyancy member (9) is above the water surface , and a second, operational position (16), where the lower buoyancy member (7) and the major parts or all the extension of the pillars (8) is below the water surface.

Nucleic acid detection method

Solid-phase nucleic acid isolation

High throughput epitope identification and t cell receptor specificity determination using loadable detection molecules

The present invention relates to detection of interactions between antigenic peptides and binding partners, such as T cell receptors (TCR) and antigenic peptide responsive T cells. In particular, the present invention relates to the provision of loadable detection molecules with peptide-free MHC molecules utilized for high throughput epitope identification and TCR specificity determination. Each of the at least one antigenic peptide is represented by at least two different detectable labels, or at least one detectable label which is a nucleic acid label. The interaction between a T cell receptor (TCR) or antigenic peptide responsive T cell and a library of antigenic peptides can be determined. The T peptide-free MHC class I molecule comprise a heavy chain comprising an alpha-1 domain and an alpha-2 domain connected by a disulfide bridge, with a mutant cysteine residue positioned at amino acid residue 84 or 85 in the alpha-1 domain and a mutant cysteine residue positioned at amino acid residue 139 in the alpha-2 domain. A composition comprising at least two loadable detection molecules or at least three loadable detection molecules each comprising a different detectable label is also claimed.

CD8 as an inhibitor of the cellular immune system

BIFUNCTIONAL POLYPEPTIDES

A bifunctional polypeptide comprising a specific binding partner for a peptide-MHC epitope, such as an antibody or a T cell receptor ("TCR"), and an immune effector, such as an antibody or a cytokine, the immune effector part being linked to the N- terminus of the peptide-MHC binding part.

An insulating wall, a column assembly therefor, and a method of constructing the insulating wall

The present invention concerns a columns assembly for an insulating wall of a building structure, said column having a side surfaces adapted to receive and retain insulation panels of the insulating wall, said column assembly comprising an inner spacer element made of mineral wool fibres, a central element made of mineral wool fibres, an outer spacer element made of mineral wool fibres, wherein the spacer elements are assembled with first and second intermediate profiles between the spacer elements, and wherein the density of the mineral wool in the central element is higher than the density in the inner and outer spacer elements. The invention also concerns an insulating wall assembly of a building structure with such a column assembly and a method of constructing such insulating wall.

Multivalent t cell receptor complexes

The present invention relates to a synthetic multivalent T cell receptor complex for binding to an MHC-peptide complex, which multivalent T cell receptor complex comprises a plurality of T cell receptors specific for the MHC-peptide complex. It is preferred that the T cell receptors are refolded recombinant soluble T cell receptors. The synthetic multivalent T cell receptor complex can be used for delivering therapeutic agents or for detecting MHC-peptide complexes, and methods for such uses are also provided.

Crystal metabolite recovery

A method for producing a crystalline and/or amorphous metabolite suspension from a cell fermentation broth in a continuous centrifuge process comprising (a) adding at a separate inlet to the centrifuge the fermentation broth comprising the cells and the metabolite of interest, wherein the metabolite is partly or wholly on crystalline and/or amorphous form; (b) adding at another inlet to the centrifuge an aqueous liquid comprising a salt and/or a carbohydrate having a higher density than the cells and a lower density than the metabolite of interest in its precipitated form; (c) removing the cells at a separate outlet to the centrifuge; and (d) removing the suspension comprising the crystalline and/or amorphous metabolite of interest at another outlet to the centrifuge.

Optical displacement sensor

T cell receptor display

A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identification of high affinity TCRs. Several high affinities are disclosed.

Tcr libraries

The present invention relates to a library of particles, the library displaying a plurality of different T cell receptors (TCRs), wherein the plurality of TCRs consists essentially of TCRs comprising an alpha chain variable domain from a natural repertoire and a beta chain variable domain from a natural repertoire, wherein the alpha chain variable10 domain comprises a TRAV12-2 or a TRAV21 gene product and the beta chain variable domain comprises a TRBV6 gene product.

Dynamic allocation of random access time slots in a mobile communication system

A processor (108) for use in a fixed infrastructure (101) of a communication system (100) (eg TETRA) including also a plurality of mobile stations (109, 110) each operable to request on a control channel by a random access procedure access to a shared communication resource (PDCH) of the system, the processor being operable to adjust dynamically, according to a detected demand as measured by a number of collisions occurring in a given period of time, a number of random access opportunities (i.e time slots) available to the mobile stations to make requests for access to the shared resource by the random access procedure.

Bifunctional polypeptides

Una molécula bifuncional que comprende un compañero de unión polipeptídico específico para un epítopo de pMHC dado, y un polipéptido efector inmunológico, estando el extremo N-terminal del compañero de unión a pMHC unido al extremo C-terminal del polipéptido efector inmunológico, CON LA CONDICIÓN DE QUE dicho compañero de unión polipeptídico no sea un receptor de linfocitos T que comprenda la cadena alfa de SEQ ID No: 7 y la cadena beta de SEQ ID No: 9 y en la que el polipéptido efector inmunológico es una citocina. A bifunctional molecule comprising a polypeptide binding partner specific for a given pMHC epitope, and an immune effector polypeptide, the N-terminal end of the pMHC binding partner being attached to the C-terminal end of the immune effector polypeptide, WITH THE CONDITION THAT said polypeptide binding partner is not a T-lymphocyte receptor that comprises the alpha chain of SEQ ID No: 7 and the beta chain of SEQ ID No: 9 and wherein the immune effector polypeptide is a cytokine.

Immunoassay for pesticides and their degradation products