Enantiomerically pure aminoheteroaryl compounds asprotein kinase inhibitors.

Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors.

Enantiomerically pure aminoheteroaryl compounds asprotein kinase inhibitors

Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors

Heteroaryl amides useful as KIF18A inhibitors

The present invention relates to chemical compounds having a general formula (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

INTERCALATED SINGLE-CHAIN VARIABLE FRAGMENTS

Single chain antibody polypeptides with engineered peptide bond crossovers in the light chain and/or heavy chain variable domains, compositions comprising the same, and methods of making and using the same are provided. The antibody polypeptides can be intercalated (crossover) single chain variable fragments (scFvs) or any antibody frameworks which comprise such scFvs, such as diabodies, bispecific antibodies or bssFvs. The single chain antibody polypeptides may or may not contain a linker. The single chain antibody polypeptides are useful in applications where standard (conventional) scFvs are useful, such as in the development of scFv libraries for screening, as therapeutic antibodies, or in in vitro and in vivo targeting applications.

Preparation method of binuclear copper complex with anti-tumor activity

The invention discloses a preparation method of a binuclear copper complex with anti-tumor activity. The preparation method comprises the steps of synthesizing a ligand H4L with branched-chain amino acid, and then, preparing the binuclear copper complex by using H4L. Compared with the prior art, the binuclear copper complex prepared by using the method has the advantages that tumor cells can fall off close to walls, meanwhile, shrinkage and separation phenomena are generated, and the amount of the tumor cells is reduced. The binuclear copper complex has a favorable inhibiting effect on hepatoma carcinoma cells (HepG2), human cervical carcinoma cells (HeLa) and human prostatic cancer (PC3).

Fiber optical laser of L waveband with wavelength tunable

The invention relates to a fiber optical laser of an L waveband with tunable wavelength, which is characterized by wide tuning range, simple structure, narrow width of output laser ray and high stability and etc. The fiber optical laser of an L waveband with tunable wavelength comprises a light source and an annular laser chamber, wherein the light source is used for transmitting the light into the annular chamber; the light is partially output by a coupler, and the another part of the light is sent to an optical fiber grating filter with mechanical sensing growth cycle which is in transition connection with the interior of the annular chamber, wherein the optical fiber grating filter with mechanical sensing growth cycle comprises a pressure groove template of which the cycle is P; the pressure groove template is matched with a pair of smooth base plates; an optical fiber of an optical fiber grating with a growth cycle to be written and a balance optical fiber are arranged between the two ...

Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors

Enantiomerically pure compound of formula (I) are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

METHOD, APPARATUS, AND MEDIUM FOR PROCESSING SPEECH SIGNAL

According to embodiments of the disclosure, a method and an apparatus for processing a speech signal, and a computer-readable storage medium are provided. The method includes obtaining a set of speech feature representations of a speech signal received. The method also includes generating a set of source text feature representations based on a text recognized from the speech signal, each source text feature representation corresponding to an element in the text. The method also includes generating a set of target text feature representations based on the set of speech feature representations and the set of source text feature representations. The method also includes determining a match degree between the set of target text feature representations and a set of reference text feature representations predefined for the text, the match degree indicating an accuracy of recognizing of the text. 1. A method for processing a speech signal , comprising:obtaining a set of speech feature representations of a speech signal received;generating a set of source text feature representations based on a text recognized from the speech signal, each source text feature representation corresponding to an element in the text;generating a set of target text feature representations based on the set of speech feature representations and the set of source text feature representations; anddetermining a match degree between the set of target text feature representations and a set of reference text feature representations predefined for the text, the match degree indicating an accuracy of recognizing of the text.2. The method of claim 1 , further comprising:performing a non-linear transformation on a speech feature representation in the set of speech feature representations; andreplacing the speech feature representation in the set of speech feature representations with the speech feature representation subjected to the non-linear transformation.3. The method of claim 1 , wherein generating ...

PYRAZOL SUBSTITUTING AMINOHETEROARYLVERBINDUNGEN AS PROTEINKINASEHEMMER

Generation of modified polymerases for improved accuracy in single molecule sequencing

CHARACTERIZATION OF MODIFIED NUCLEIC ACIDS

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

GENERATION OF MODIFIED POLYMERASES FOR IMPROVED ACCURACY IN SINGLE MOLECULE SEQUENCING

Provided are compositions comprising modified recombinant polymerases that exhibit branching fractions that are less than the branching fractions of the polymerases from which they were derived, or branching fractions that are less than about 25% for a phosphate-labeled nucleotide analog. Also provided are compositions comprising modified recombinant polymerases that exhibit closed polymerase/DNA complexes with increased stability relative to the parental polymerases. Also provided are compositions comprising modified recombinant polymerases that exhibit decreased rate constants relative to the parental polymerases. Provided are methods for generating polymerases with the aforementioned phenotypes. Provided are methods of using such polymerases to make a DNA or to sequence a DNA template.

Real-time traffic condition information generating method and system thereof

The invention discloses a real-time traffic condition information generating method which comprises the steps of: automatically receiving broadcast; performing speed recognition on a broadcast signal, performing keyword detection, extracting traffic condition information from the broadcast signal, and converting the traffic condition information to text information; converting the text information to a map feature language through natural language processing technique, drawing and feeding back in a map product for forming traffic condition information. Correspondingly, the invention further provides a real-time traffic condition generating system. The real-time traffic condition information generating method can provide real-time traffic condition information for users in a wide area. Based on the real-time traffic condition information, a series of applications of navigation, going-out planning, etc. can be performed. Furthermore a large amount of labor can be saved for a traffic condition ...

Method for preparing soybean sauce rich in soluble dietary fibers

The invention relates to a method for preparing soybean sauce rich in soluble dietary fibers, which comprises the following steps: (1) after bean dreg raw materials are mixed and sterilized, cooling the raw materials to between 40 and 50 DEG C, adjusting the pH to between 3.3 and 3.5, adding composite cellulase into the raw materials to carry out enzymolysis for 0.8 to 1.2 hours, and then raisingthe temperature to between 85 and 95 DEG C to inactivate the enzyme for 8 to 12 minutes; (2) after the enzyme is inactivated, grafting mildew to the raw materials, and culturing the raw materials for24 to 48 hours by shaking fermentation to obtain mature fermentation liquid; and (3) adding a quality modifier into the fermentation liquid, and blending and homogenizing the mixture to obtain a finished product of the soybean sauce rich in the soluble dietary fibers. The dietary fibers in the bean dregs are micronized through the actions of the cellulase and microbe so as to increase the amount of the ...

High-efficiency easy-cleaning sullage heat exchanger

The invention relates to a multipurpose use device for low grade energy, namely, a high-efficiency cleaning sewage heat exchanger. The device comprises a sewage box body, the top of which is provided with a flat-shaped top plate. The sewage box body is internally distributed with more than two snakelike heat exchange tubes evenly. The upper part of the snakelike heat exchange tubes is connected with the inner side surface of the top plate. The inner bottom of the sewage box body is evenly distributed with a lower transverse baffle, the upper part of which extends into the convex position of the snakelike heat exchange pipe. The inner side surface of the top plate is evenly distributed with an upper transverse baffle, the lower part of which extends into a concave downward position of the snakelike heat exchange pipe. The upper part of the sewage box body is provided with a sewage inlet defrosting pan, the lower part is provided with a sewage outlet and the bottom is provided with a water ...

Triazolopyrazine derivatives useful as anti-cancer agents

The invention relates to compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein R<1>, R<2>, R<3> and R<4> are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula (I).

Maintenance method and device for direct-current transmission common grounding electrode system and computer equipment

The invention discloses a direct current transmission common grounding electrode system maintenance method and device and computer equipment. The method comprises the steps that a simulation model comprising a direct-current power transmission common grounding electrode system and a target direct-current power transmission line is established, the direct-current power transmission common grounding electrode system comprises multiple grounding electrode lines and a common grounding electrode, the multiple grounding electrode lines are used for connecting the corresponding multiple direct-current power transmission lines to the common grounding electrode, and the common grounding electrode is used for connecting the multiple direct-current power transmission lines to the target direct-current power transmission line; the plurality of direct-current power transmission lines comprise a target direct-current power transmission line; according to the simulation model, determining electric power ...

Data storage method and device, storage medium and electronic equipment

The invention discloses a data storage method and device, a storage medium and electronic equipment. The method comprises the steps of obtaining target time sequence data to be stored or stored; time dimension reduction processing is conducted on the target time sequence data, time sequence data tables of at least two different time dimensions are obtained, and the time sequence data tables are used for recording time sequence data under all the time dimensions; and performing dimension reduction storage on the target time sequence data according to the at least two time sequence data tables with different time dimensions. The technical problem of low data storage efficiency is solved.

ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS

Enantiomerically pure compound of formula (I) are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers. © KIPO & WIPO 2007 ...

AS ANTI-CANCER MEANS APTITUDE TRIAZOLOPYRAZINDERIVATE

sGC Stimulators

Abstract Compounds of Formulae I' and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed. j (Jc)p N (JB R. N ,1(JB)N N D \ 2 X2- (JD) jA jD Formula I' Formula I ...

HETEROARYL AMIDES USEFUL AS KIF18A INHIBITORS

The present invention relates to chemical compounds having a general formula (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

Radiation tail end performance testing device based on control radiation plates

The invention relates to a radiation tail end performance testing device based on control radiation plates. The device includes a to-be-tested radiation tail end and an enclosed and heat retaining test cabinet. Inner-side walls of the test cabin are provided with a cabinet wall temperature control system. An in-cabinet temperature measurement system for measuring in-cabinet temperature and inner-side wall temperatures of the test cabin is also arranged in the test cabin. The to-be-tested radiation tail end is arranged in the test cabin, close to the inner-side walls of the test cabin. The to-be-tested radiation tail end is connected with a corresponding to-be-tested-radiation-tail-end water system, which is arranged outside the test cabin, through a pipe. The cabinet wall temperature control system includes the control radiation plates which cover the inner-side walls of the test cabin. The testing device controls and simulates a practical wall temperature through the control radiation ...

Dust collecting pipe having telescope steel nozzle

The invention discloses a dust-absorbing tube with collapsible rigidity dust-absorbing tube, which is characterized by the following: comprising collapsible rigidity dust-absorbing pipe connection, absorbing joint on the end of the dust-absorbing tube, dust-absorbing host with handle connected to the other end of the dust-absorbing pipe; setting the collapsible rigidity dust-absorbing pipe as collapsible host, first support, last support, locking bolt group; fixing the first support on one end of the host; fixing the last support on the other end of the host; inserting the last support into the first support; fixing shift length of the fist and last support with the locking bolt group. This invention possesses the advantages of simple structure, light weight and low cost.

Fixation rack with cover of dust-collecting bag for dust collector

The invention relates to a fixed mount provided with a cover for the dust collecting bag of a cleaner and is applied to the arrangement of disposable dust collecting bags. Two sides of the upper part of the fixed mount is provided with two front arms protruding forward, a groove is arranged respectively at the inner side of the two front arms and the openings of the grooves are formed in an inwardly opposite manner. An oblong cover plate is arranged between the two front arms and the size of the cover plant is preferably the size totally covering the gas inlet of the dust collecting bag. The two sides of the cover plant are inserted into the grooves at the inner side of the front arms so as to cause the cover plate to move along the inner side of the front arms. The cover plate is arranged over a fixed plate at the upper part of the dust collecting bag and with two sides inserted into the grooves of the front arms and the movable cover plate can cover round holes forming the gas inlet of ...

Adjustable unmanned aerial vehicle surveying and mapping data acquisition device

The invention relates to the technical field of unmanned aerial vehicles, and particularly discloses an adjustable unmanned aerial vehicle surveying and mapping data acquisition device, which comprises an unmanned aerial vehicle body, driving motors are mounted at four corners of the top of the unmanned aerial vehicle body, propellers are mounted at top output ends of the plurality of driving motors, and a protection mechanism is mounted at the top of the unmanned aerial vehicle body. A device body is arranged at the bottom of the unmanned aerial vehicle body, the unmanned aerial vehicle body can install the device body through an installed installation mechanism, the installation mechanism comprises two clamping plates, and the outer walls of the sides, close to each other, of the two clamping plates abut against the outer wall of the device body. According to the unmanned aerial vehicle, the mounting mechanism is arranged at the bottom of the unmanned aerial vehicle body, so that surveying ...

Preparation and application of molecular target for leukemia screening

The invention discloses preparation and application of a molecular target capable of being used for leukemia screening. The nucleotide sequence of the molecular target is as shown in SEQ ID NO: 3. If the plasma cDNA of the to-be-detected person contains the DNA sequence of which the nucleotide sequence is as shown in SEQ ID NO: 3, the to-be-detected person is a leukemia patient; if the plasma cDNA of the to-be-detected person does not contain the DNA sequence of which the nucleotide sequence is as shown in SEQ ID NO: 3, the to-be-detected person is not the leukemia patient. The kit has the advantages of small trauma, high patient compliance, high detection specificity and sensitivity, simplicity in operation, convenience in material taking and the like, and has an important application value in early screening of leukemia patients.

Preparation method and application of lung cancer cell model with increased proliferation rate

The invention discloses a preparation method and application of a lung cancer cell model with an improved proliferation rate. Based on a dCas9-KRAB transcription inhibition system, after puromycin screening, an A549 stable expression cell line with the highest dCas9 protein relative expression quantity is obtained, and subsequently, sgRNA targeting one or more genes can be introduced into the cell line to inhibit endogenous gene expression in lung cancer cells and research related functional genes. Furthermore, sgRNA of a TP53 binding site in a targeted LTR5Hs sequence is introduced into the cell line, the A549 cell line with the proliferation rate remarkably improved is prepared, the A549 cell line can serve as a disease model to be used for screening drugs for inhibiting lung cancer cell proliferation, and the A549 cell line has important significance on lung cancer treatment and mechanism research.

Vehicle-mounted controller and vehicle-mounted controller design method

The invention discloses a vehicle-mounted controller and a vehicle-mounted controller design method, the vehicle-mounted controller comprises a vehicle domain controller VDCU, a vehicle domain controller BDCU and a central gateway GW, the VDCU, the BDCU and the GW adopt the same multi-core processor, and programs are deployed in different processor cores to serve as central controllers CCUs; the CCU is used for controlling vehicle peripherals within a preset distance range; the CCU is connected with a terminal actuator TAU and used for controlling vehicle peripherals outside a preset distance range through the TAU. According to the invention, the integration of the vehicle domain controller is realized, and the central controller CCU is obtained. The total quantity of cables is reduced on the hardware level, and the cable cost is reduced. The number of domain controllers is reduced on the software level, so that the software development efficiency is improved.

PYRAZOLE-SUBSTITUTED AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS

Jedinjenje formule 1gde su:Y je CR12;A je fenil, supstituisan sa jednom, dve ili tri R3 grupe; R1 se bira izmeuopciono supstituisanim sa jednom, dve ili tri R13 grupe; R2 je vodonik;R3 svaki nezavisno, je halogen, C1-12 alkil, C2-12 alkenil, C2-12 alkinil, C3-12 cikloalkil, C6-12 aril, 3-12-lani heterocikloaliciklil, 5-12-lani heteroaril, -S(O)mR4, -SO2NR4R5, -S(O)2OR4, -NO2, -NR4R5, -CN, -C(O)R4, -OC(O)R4, -O(CR6R7)nR4, -O(CR6R7)(CR6R7)nNR4R5, -O(CR6R7)(CR6R7)nOR4, -NR4C(O)R5, -(CR6R7)nC(O)OR4, -(CR6R7)nOR4, -(CR6R7)nC(O)NR4R5, -C(=NR6)NR4R5, -NR4C(O)NR5R6, ili -NR4S(O)pR5;R4, R5, R6 i R7 svaki nezavisno, je vodonik, halogen, C1-12 alkil, C2-12 alkenil, C2-12 alkinil, C3-12 cikloalkil, C6-12 aril, 3-12-lani heterocikloaliciklil, 5-12-lani heteroaril;R9 je metil, aR10 je vodonik;R12 je vodonik;R13 svaki nezavisno, je halogen, C1-12 alkil, C2-12 alkenil, C2-12 alkinil, -S(O)mR4, -SO2NR4R5, -S(O)2OR4, -NO2, -NR4R5, -CN, -OC(O)R4, -O(CR6R7)nR4, -NR4C(O)R5, -(CR6R7)nC(O)OR4, -(CR6R7)nOR4, - ...

CLASSIFICATION OF NUCLEIC ACID TEMPLATES

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid. 1. A method of determining a sequence of a double-stranded nucleic acid sample and a position of at least one modified base in the sequence , comprising:a) locking the forward and reverse strands of the nucleic acid sample together to form a circular pair-locked molecule;b) obtaining sequence data of the circular pair-locked molecule via single molecule sequencing, wherein sequence data comprises sequences of the forward and reverse strands of the circular pair-locked molecule; andc) determining the sequence of the double stranded nucleic acid sample and the position of the at least one modified base in the sequence of the double stranded nucleic acid sample by comparing the sequences of the forward and reverse strands of the circular pair-locked molecule.2. The method of claim 1 , wherein the double stranded nucleic acid sample comprises at least one modified base chosen from 5-bromouracil claim 1 , uracil claim 1 , 5 claim 1 ,6-dihydrouracil claim 1 , ribothymine claim 1 , 7-methylguanine claim 1 , hypoxanthine claim 1 , and xanthine.3. The method of claim 1 , wherein at least one modified base in the double-stranded nucleic acid sample is paired with a base with a base pairing specificity different from its preferred partner base.4. A method of determining a sequence of a double-stranded nucleic acid sample and a position of at least one modified base in the sequence claim 1 , comprising:a) locking the forward and reverse strands of the nucleic acid sample together to form a circular pair-locked ...

ENANTIOMERENREINE AMINOHETEROARYL CONNECTIONS AS PROTEINKINASEHEMMER

Heteroaryl amides useful as KIF18A inhibitors

The present invention relates to chemical compounds having a general formula (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

TRIAZOLOPYRAZINE DERIVATIVES USEFUL AS ANTI-CANCER AGENTS

The invention relates to compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula (I).

Overhanging type steel platform intelligent load limiter

The invention relates to an intelligent load limiter for an overhanging type steel platform, which consists of a sensor processing unit, a terminal operation unit and an alarm unit which are arranged inside a box respectively and connected with each other through serial ports, wherein the sensor processing unit consists of a sensor and a single chip microprocessor; the terminal operation unit consists of a single chip microprocessor, a nixie tube and a scanning matrix keyboard and transmits a command to the sensor processing unit; and the alarm unit consists of an accumulator, an audible and visual alarm and a detection circuit and automatically starts the audible and visual alarm and the internal accumulator when overloading and power supply failures occur. When the loading and unloading platform is operated in the form of excess load, the intelligent load limiter can alarm in time, so that the intelligent load limiter can effectively inhibit safety misadventures, guarantee personal safety ...

Vacuum adsorption tool

The utility model discloses a vacuum adsorption tool uses with evacuating device cooperation, and vacuum adsorption tool includes the base, the base top is equipped with the product location board, be equipped with a plurality of product location grooves on the product location board, place the product on the product location groove, product location tank bottom portion is equipped with a plurality of vacuum and inhales the hole, the vacuum of product location inslot is inhaled the one end that the hole is being close to the product and all is located the coplanar, the base bottom is equipped with vacuum suction box, the inside cavity that is equipped with of vacuum suction box, cavity and each the hole intercommunication is inhaled in the vacuum, vacuum suction box further with evacuating device connects. The product location groove can prevent that the product from removing at the horizontal direction, the hole is inhaled in the vacuum can hold the product bottom surface, and it is effectual ...

Parallel discharge method, storage medium and electronic equipment

The invention provides a parallel discharge method, a storage medium and electronic equipment. The method comprises the following steps: controlling a plurality of target discharge equipment connected in parallel to periodically discharge; the discharge processing comprises the following steps: acquiring data information hi = (Qi, Ui) of the ith target discharge equipment; qi is the to-be-discharged capacity of the battery in the ith target discharge equipment, Ui is the terminal voltage of the battery in the ith target discharge equipment, n is the number of the target discharge equipment, and n is larger than 1; imax is the rated maximum discharge current of the internal battery of the target discharge equipment; controlling the ith target discharge equipment in the plurality of target discharge equipment to discharge at Umin and Ii; ii = Qi/(Umin * t); t is equal to Qmax/(Umin * Imax). Therefore, the discharging efficiency of parallel discharging of the multiple target discharging devices ...

Aminoheteroaryl compounds as protein kinase inhibitors

Intercalated single-chain variable fragments

Single chain antibody polypeptides with engineered peptide bond crossovers in the light chain and/or heavy chain variable domains, compositions comprising the same, and methods of making and using the same are provided. The antibody polypeptides can be intercalated (crossover) single chain variable fragments (scFvs) or any antibody frameworks which comprise such scFvs, such as diabodies, bispecific antibodies or bssFvs. The single chain antibody polypeptides may or may not contain a linker. The single chain antibody polypeptides are useful in applications where standard (conventional) scFvs are useful, such as in the development of scFv libraries for screening, as therapeutic antibodies, or in in vitro and in vivo targeting applications.

DISTRIBUTED STEAM GENERATION PROCESS FOR USE HYDROCARBON RECOVERY OPERATIONS

A method and system for producing steam for use in heavy hydrocarbon recovery operations. In an arrangement with or without a central processing facility and/or a plurality of well pads in communication with the central processing facility, each well pad is provided with equipment for separation of materials produced from its respective wells, and steam generation equipment for that well pad, thus allowing for simplified piping transport.

CLASSIFICATION OF NUCLEIC ACID TEMPLATES

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

TRIAZOLOPYRAZINE DERIVATIVES USEFUL AS ANTI-CANCER AGENTS

The invention relates to compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula (I).

Microelectronic element with elastic conductive projection and method of manufacture

The invention provides a micro-electronics component which has an elastic electric conduction ridge, including the semiconductor chip and conductance ridge which establishes on the semiconductor chip surface, its characteristic lie in: the conductance ridge includes a conducting layer and an elastic conducting layer, the conducting layer electric interlocks with the semiconductor chip surface weld pad, the elastic conducting layer connects with the conducting layer metallurgy. Simultaneously it provided the manufacture method of the micro-electronics component, as well as the seal structure and the liquid crystal display installment. According to the invention, no need to use anisotropy conducting resin coating, the obtained seal structure compares to which used the anisotropy conducting resin coating, it has the lower connection resistance, simultaneously avoids short-circuiting occurrence.

Smoothing method for image processing and mode identification through computer

The invention helps to solve the problems of the prior art that although noise or abnormity can be handled to a certain degree during image processing and mode identification through a computer, defects such as image fuzzy conditions, edge detail distortion and the like often exist. During an image processing and mode identification process through a computer, a comparison operation algorithm, a root operation algorithm and a median operation algorithm are utilized to handle abnormity or noise data. Therefore, high-precision data of high quality can be obtained, and the influence of noise or abnormity upon an image processing and mode identification result is effectively eliminated.

Transformer fault determination method and device, and transformer

The invention discloses a transformer fault determination method and device, and a transformer. The method comprises the steps that vibration signals of the transformer are acquired, and the vibration signals are acquired by a plurality of sensors which are arranged at different positions of the transformer in advance; performing fusion processing on the vibration signal to obtain a fused vibration signal; performing modal decomposition on the fused vibration signal to obtain a modal function component of the vibration signal; determining a time domain characteristic value and a frequency domain characteristic value of the modal function component; and determining whether the transformer has a fault or not according to the size relationship between the time domain characteristic value and the corresponding reference threshold value and the size relationship between the frequency domain characteristic value and the corresponding reference threshold value. According to the invention, the ...

HETEROARYL AMIDES USEFUL AS KIF18A INHIBITORS

The present invention relates to chemical compounds having a general formula (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

STEAM GENERATION SYSTEM

A system and method for generating steam comprising a low energy water treatment and a forced circulation steam generator. The low energy water treatment preferably comprises subjecting the feedwater to one or both of warm lime softening treatment and hot lime softening treatment, and further subjecting the feedwater to one or both of weak acid cation exchange treatment and strong acid cation exchange treatment. The low energy water treatment may comprise a membrane system, electro-coagulation system, or any other alternative to evaporation, and combinations of the same.

PARTIAL UPGRADING SYSTEM AND METHOD FOR HEAVY HYDROCARBONS

Systems and methods for partially upgrading a produced heavy hydrocarbon resource at the production site (at the pad or a central processing facility) using indirect hydrogen addition, comprising a blender for blending the hydrocarbon with a hydrogen donator and a reactor for elevating the mixture to a temperature sufficient to hydrogenate the hydrocarbon to an API level required for pipeline specifications. The partially upgraded hydrocarbon can then be transported by pipeline to a refinery for further processing. The presence of catalysts and on-site hydrogen production equipment conventionally required for upgrading is eliminated. Further, the need for diluent which is conventionally used to enable pipelineability of produced heavy hydrocarbon is reduced or eliminated, thus reducing the diluent freight cost and the required pipeline volume.

Traffic optimization control method based on intersection group

The invention discloses an optimal control method for intersection group traffic flow, which resolves the defect that the smallest unit of current urban traffic control is a single intersection, which cannot satisfy the needs of actual traffic control, can realize the optimization of local traffic flow, and provides helps for micro control of traffic flow. The steps of the method are:(1) real time acquiring actual traffic flow of ''intersection group'' on roads through a ground induction coil which has been paved in a city; (2) constructing an optimal control model with a smart approach and inferring and optimizing the parameters of a controller according to real-time traffic information;(3) the controller carrying out optimal control for traffic flow according to the control model.

Log fault classification model training method and device, equipment and storage medium

The invention discloses a log fault classification model training method and device, equipment and a storage medium. The method comprises the following steps: acquiring a system application log; determining a preorder application log and a postorder application log of the system application log according to the log generation time of the system application log; determining a current log template corresponding to the system application log, a preorder log template corresponding to the preorder application log and a post-order log template corresponding to the post-order application log; constructing feature vectors of the system application logs according to the current log template, the preorder log template and the post-order log template; determining a fault type of the system application log according to the log generation time; constructing a sample training set according to the fault category and the feature vector of the system application log; and training a preset fault classification ...

EXTENSIBLE PIPE FOR VACUUM CLEANER

The present invention relates to an extensible pipe capable of extending and adjusting a length thereof, comprising: an inner pipe, an outer pipe, and a locking device. The inner pipe is inserted into the outer pipe to be connected to be able to slide. The locking device is installed in one end of the outer pipe, and includes a sliding cover plate and a base. The base is projected out to the outside through an installation groove formed in an expanding pipe of one end of the outer pipe from the inside to the outside and the sliding cover plate is connected to the base to be able to move in an axial direction. According to the present invention, the sliding cover plate covers a top of the base, and provides a kind of extensible pipe to cover a section corresponding to the base on an outline of the outer pipe, and a compact and simple locking device is installed, so a user receives enhanced pleasantness and convenience during use, and manufacturing and production capability are also enhanced ...

Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors

Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors

KIF18A INHIBITORS

Compounds of formula (I): (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

Method for preparing porous molybdenum metal by adopting powder metallurgy method

The invention provides a method for preparing a porous molybdenum metal by adopting a powder metallurgy method, which comprises the following steps of: mixing the weighed molybdenum powder and a pore forming agent uniformly; charging the mixture into a steel die for pressing, then drying the pressed powder blank for 6 to 8 hours at the temperature of between 40 and 60 DEG C, putting the dried pressed blank into a sintering furnace for sintering in the protective atmosphere of hydrogen at the sintering temperature of between 1,350 and 1,500 DEG C, and finally cooling the sintered product to room temperature together with the furnace; and cleaning the product by using deionized water to obtain the porous molybdenum metal. The pore distribution of the obtained material is uniform, the volume fraction of pores can be controlled, and the porous molybdenum metal has certain strength (10 to 30MPa) and porosity (55 to 90 percent) and can meet the service requirement of porous metal materials.

Distributed optical fiber sensing system and detection method utilizing same

The invention discloses a distributed optical fiber sensing system and a detection method utilizing the same. The optical fiber sensing system comprises a light source unit, an optical circulator, and a detection unit, wherein the light source unit emits light which is suitable for detecting and processing; the optical circulator receives the light which comes from the light source unit, and transmits the received light into a sensing optical fiber used for the detection; and the detection unit receives backscattered light caused by the light which enters the sensing optical fiber from the optical circulator, interference light formed by Rayleigh scattering light and scattered light of one component of Brillouin in the backscattered light through heterodyne interference is obtained in thedetection unit and is converted into an electrical signal, and the detection unit also detects the electrical signal to obtain the change of the temperature and strain in the sensing optical fiber.

Dry-type fan coil set of air-conditioning system suitable for independent temperature-humidity control

This invention discloses a dry-type fan coil set of air-conditioning system suitable for independent temperature-humidity control, comprising a set housing, a heat exchange coil, a fan and a motor connected with the fan; water discharge pipeline of the heat exchange coil is arranged on the side of the set housing near air inlet, and water charging pipeline of the same is arranged on the side of the set housing near air outlet; side of the set housing is set with a charged water collector pipe and a discharged water collector pipe; the water charging pipeline and water discharging pipeline of the heat exchange coil are respectively connected to the charged water collector pipe and the discharged water collector pipe; bottom of the set housing is set with a water disk; the heat exchange coil consists of three groups of coil units from up to down, which are connected in parallel on the charged water collector pipe and the discharged water collector pipe. Accordingly, this invention is high ...

EXPANDABLE PIPE

The present invention relates to an expandable pipe comprising first and second expandable pipes (1, 2) and a locking device (3). The locking device (3) includes a button (4), a bracket (5), and a base (7). The base (7) protrudes from the inside to the outside through a mounting groove (20a) formed on an expanded pipe (20) of one end of the second expandable pipe (2); the bracket (5) is closely fitted and fixated in a protruding part of the base (7); and the button (4) covers the entire top of the bracket (5) and, at the same time, vertically moves on the top of the bracket (5), and is coupled to the bracket (5) through a button lock (4b) formed on the button. Accordingly, a user locks and unlocks the first expandable pipe in and from the second expandable pipe by only one action to hold or release the locking device, and holds the expandable pipe with a palm to release the locking device of the expandable pipe; thereby providing an effect of enhancing easiness and convenience in use. Moreover ...

sGC Stimulators

Abstract Compounds of Formulae I' and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed. j (Jc)p N (JB R. N ,1(JB)N N D \ 2 X2- (JD) jA jD Formula I' Formula I ...

PRODUCED WATER STEAM GENERATION PROCESS USING PRODUCED WATER BOILER WITH GAS TURBINE

A method and system for producing steam for use in heavy hydrocarbon recovery operations. Water, containing impurities, produced from the well is separated from hydrocarbons and other materials, and subsequently directly passed to a produced water boiler with online pigging. The boiler is indirectly heated by means of a hot flue gas, such as a gas turbine exhaust, which produces electricity (for powering a central processing facility, or alternatively a burner to heat the boiler) and exhaust heat for heating the boiler.

PARTIAL UPGRADING SYSTEM AND METHOD FOR HEAVY HYDROCARBONS

Systems and methods for partially upgrading a produced heavy hydrocarbon resource at the production site (at the pad or a central processing facility) using indirect hydrogen addition, comprising a blender for blending the hydrocarbon with a hydrogen donator and a reactor for elevating the mixture to a temperature sufficient to hydrogenate the hydrocarbon to an API level required for pipeline specifications. The partially upgraded hydrocarbon can then be transported by pipeline to a refinery for further processing. The presence of catalysts and on-site hydrogen production equipment conventionally required for upgrading is eliminated. Further, the need for diluent which is conventionally used to enable pipelineability of produced heavy hydrocarbon is reduced or eliminated, thus reducing the diluent freight cost and the required pipeline volume.

Lifting belt for full-automatic pipe finishing and dropping device of collective doffing spinning frame

The invention relates to a lifting belt for a full-automatic pipe finishing and dropping device of a collective doffing spinning frame, which comprises a lifting belt substrate (1), lifting teeth (2), anti-stacking teeth (3) and a bobbin (4), wherein the lifting teeth (2) and the anti-stacking teeth (3) are arranged on the lifting belt substrate (1); the anti-stacking tooth (3) is arranged on the upper part of the lifting teeth (2); the bobbin (4) is arranged between the lifting teeth (2) and the anti-stacking teeth (3), and the distance between the lifting teeth (2) and the anti-stacking teeth (3) is equal to the diameter of the bobbin (4); and more than two lifting teeth (2) and more than two anti-stacking teeth (3) are arranged on the lifting belt substrate (1). The lifting belt has a simple structure and meets the requirement of inclining backwards; and by arranging the anti-stacking teeth, only one bobbin can be lifted at each time, so labors for putting pipes are reduced substantially ...

Method for preparing soybean sauce rich in soluble dietary fibers

Performance testing device of carbon dioxide refrigeration compressor for refrigeration systems

The invention relates to a performance testing device of a carbon dioxide refrigeration compressor for trans-critical and sub-critical refrigeration systems. The prior art is improved in the way that a component for pressure regulation and pressure reduction is connected between a compressor exhaust opening and an exhaust flowmeter in parallel; a safety valve component A is arranged on an oil separator; a safety valve component B is arranged on a condenser; a safety valve component C is arranged on a liquid reservoir; a subcooler is connected between a shutoff valve C of an outlet of the liquid reservoir and an electromagnetic valve in series; a safety valve component D is arranged on the subcooler; a refrigerant filling and recovering storage tank is connected between an inlet of a mass flowmeter and an outlet of a shutoff valve E in parallel; a recovering shutoff valve and a recovering electromagnetic valve are arranged at the position of an inlet of the refrigerant filling and recovering ...

CRF01AE epidemic recombinant strain LTR fluorescence report system stable transfection strain and construction method thereof

The invention discloses a stably transfected strain of a CRF01AE epidemic recombinant strain LTR fluorescence report system and a construction method of the stably transfected strain. The invention relates to the technical field of biochemistry. A carrier sequence of the luciferase reporter gene containing the HIV-1 GX002LTR is shown as a sequence 1 in a sequence table, the luciferase reporter gene containing the HIV-1 GX002LTR contains a luciferase gene expression cassette, the luciferase gene expression cassette is a double-stranded DNA molecule containing a luciferase gene and a regulatory sequence required by luciferase gene expression, a nucleotide sequence of the luciferase gene is 907th-2559th sites of the sequence 1, and a nucleotide sequence of the luciferase reporter gene containing the HIV-1 GX002LTR is a nucleotide sequence of the sequence 1. The nucleotide sequence of the regulatory sequence (LTR) is the 40th to 845th sites of the sequence 1. The HIV-1 GX002LTR fluorescence ...

Crosslinked polyethylene insulating material aging degree detection method based on yellowness evolution

The invention relates to a method for detecting the aging degree of a crosslinked polyethylene insulating material based on yellowness evolution. The method comprises the following steps: acquiring a first particle yellowness index of a first processing material particle of a target raw material particle, acquiring a second particle yellowness index of a second processing material particle of the target raw material particle, and acquiring an original particle yellowness index corresponding to the target raw material particle, according to the first particle yellowness index, the second particle yellowness index and the original particle yellowness index, production process quality description information is obtained, and according to the production process quality description information, the aging degree corresponding to the second processing material particles is determined. By adopting the method, various yellowness indexes corresponding to the material particles can be directly obtained ...

A549 stable expression cell line constructed based on dCas9-VP64 transcriptional activation system and application of A549 stable expression cell line

The invention discloses an A549 stable expression cell line constructed based on a dCas9-VP64 transcriptional activation system and application of the A549 stable expression cell line. Based on a dCas9-VP64 transcriptional activation system, after puromycin screening, an A549 stable expression cell line with the highest dCas9 protein relative expression quantity is obtained, and subsequently, sgRNA targeting one or more genes can be introduced into the cell line to activate endogenous gene expression in lung cancer cells and carry out research on related functional genes. Furthermore, sgRNA of a TP53 binding site in a targeted LTR5Hs sequence is introduced into the cell line, and the A549 cell line with the proliferation rate remarkably reduced is prepared. The invention discovers a new target spot for treating lung cancer for the first time, and has important significance for lung cancer treatment and mechanism research.

Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors

Enantiomerically pure compound of formula 1, are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

Amide compounds for inhibiting protein kinases

GENERATION OF MODIFIED POLYMERASES FOR IMPROVED ACCURACY IN SINGLE MOLECULE SEQUENCING

Provided are compositions comprising modified recombinant polymerases that exhibit branching fractions that are less than the branching fractions of the polymerases from which they were derived, or branching fractions that are less than about 25% for a phosphate-labeled nucleotide analog. Also provided are compositions comprising modified recombinant polymerases that exhibit closed polymerase/DNA complexes with increased stability relative to the parental polymerases. Also provided are compositions comprising modified recombinant polymerases that exhibit decreased rate constants relative to the parental polymerases. Provided are methods for generating polymerases with the aforementioned phenotypes. Provided are methods of using such polymerases to make a DNA or to sequence a DNA template.

Uterus lifting machine

The utility model provides an uterus lifting machine, aim at solves, when carrying out the operation of peritoneoscope uterus, because operation time is long, controls whole palace frame and can bring very big burden for medical staff, needs solitary medical personnel to operate moreover, has the problem of great drawback. Its technical scheme is, including lifting the palace frame, whole palace frame on be connected with latch device, latch device be connected with the dead lever, the adjustable length of dead lever, latch device be connected with the dead lever, the lower extreme of dead lever be equipped with with ground matched with fixing base. The utility model discloses simple structure can lock the act palace at the operation in -process and put up the angle in vertical plane and horizontal plane, fixes a position lifting palace frame realization, can reduce substantially medical staff and pay in the in -process physical power of performing the operation, can subtract solitary whole ...

Horizontal moving platform hung at high altitude

The invention relates to a horizontal moving platform hung at a high altitude. The horizontal moving platform is mounted on a main steel structure and comprises two fixed steel wire ropes, two sliding steel wire ropes, a plurality of U-shaped buckles, a basket body, a perforated steel plate mesh guardrail, life ropes and rope buckles; the two ends of each of the fixed steel wire ropes are respectively wound on the main steel structure, the end part of the fixed steel wire rope is fixed by the rope buckles; each sliding steel wire rope passes by the bottom of the basket body, and the end part of the sliding steel wire rope is connected with the fixed steel wire rope through the U-shaped buckles; the U-shaped buckles can move along the fixed steel wire ropes; the perforated steel plate mesh guardrail is arranged on the periphery of the basket body; the life ropes are independently arranged on the main steel structure. The horizontal moving platform hung at the high altitude has the benefits ...

Axial-flow fan with forwards folded outer edges of vanes

The invention belongs to the field of fluid machinery and relates to design and manufacture of a sheet vane type axial-flow fan. In an axial-flow fan with forwards folded outer edges of vanes, the outer edges of sheet vanes of an impeller of the axial-flow fan are made into aerofoil-shaped forward folds perpendicular to the working surfaces of the vanes, and an enveloping surface parallel to the axes of the fan is formed and a certain axial aerodynamic force is generated during operation of the impeller, so that the loss of radial flow and whirling flow of air in the impeller is reduced when the axial-flow fan works, and the goals of efficiency improvement and noise reduction are achieved. The invention has simple structure, easy operation, obvious effect, considerable practical value and favorable market prospect.

Transaction volume anomaly detection method and device, equipment and storage medium

The invention discloses a transaction volume anomaly detection method and device, equipment and a storage medium. The method comprises the following steps: acquiring transaction volume data in a to-be-tested time period; carrying out aggregation processing on the transaction volume data to obtain an actual transaction volume corresponding to the to-be-tested time period; acquiring historical transaction volume data according to the to-be-tested time period; according to the historical transaction volume data, determining a predicted transaction volume range of the to-be-tested time period; and determining whether the actual transaction volume in the to-be-tested time period is abnormal or not according to the predicted transaction volume range. According to the technical scheme of the embodiment of the invention, the transaction volume anomaly detection mode is simplified, the detection efficiency and the detection accuracy are improved at the same time, and the method is more universal ...

Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors

sGC stimulators

Compounds of Formulae (I') and (I) are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Classification of nucleic acid templates

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

sGC Stimulators

Abstract Compounds of Formulae I' and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed. j (Jc)p N (JB R. N ,1(JB)N N D \ 2 X2- (JD) jA jD Formula I' Formula I ...

KIF18A INHIBITORS

Compounds of formula (I): (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

FUSED BICYCLIC SGC STIMULATORS

The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable. The compounds are of Formula (I).

CLASSIFICATION OF NUCLEIC ACID TEMPLATES

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

TRIAZOLOPYRIDAZINE DERIVATIVES

The invention relates to compounds of the formula (I) or a pharmaceutical ly acceptable salt thereof, wherein R1, R2, R3 and R3 ' are as defined herei n. The invention also relates to pharmaceutical compositions containing the compounds of formula (I) and to methods of treating hyperproliferative disor ders in a mammal by administering the compounds of formula (I).

Automatic end liquid transfusion system

The utility model relates to an automatic end liquid transfusion system, including the dropping funnel, dropping funnel upper portion is connected with the feed liquor hose, and feed liquor hose upper portion is connected with luer connector, and luer connector upper portion is connected with bottle stopper puncture device, and the dropping funnel sub -unit connection has the automatic liquid -stopping device, and automatic liquid -stopping device sub -unit connection has the liquid of confession hose, supplies liquid hose right side to be connected with the filter, and the filter right side is connected with out the liquid hose, and it has the vein needle to go out liquid hose sub -unit connection, and vein needle upper portion is provided with the needle wing. The inside only liquid film that is provided with of automatic liquid -stopping device. It is provided with a class speed adjusting festival ware to go out liquid hose intermediate position. The utility model discloses an automatic ...

Unclosing structure of vertical cleaner dust collecting device

The invention discloses an opening structure of vertical cleaner dust collecting device, which comprises the following parts; the cleaner body, a dust collecting device capable of being assembled and disassembled on the body, a dust collecting drum used for absorbing the foreign bodies, an upper cover used for covering the upper surface of the dust collecting grum and a handle formed on the uppercover. The invention is characterized in that: a sunken is formed at one side of a sponge cover of the upper cover and a heave is shaped on the surface of the dust collecting drum; a fixed part is shaped on a dust cap of the upper cover, which is connected with a key-press. The invention has the advantages of deduced parts and lowered cost, which is convenient for customer to use and is beautifulat the same time.

Method and device for predicting operation state of service system, equipment and medium

The invention discloses a method, device and equipment for predicting the running state of a service system and a medium, and relates to the technical field of computers. Comprising the following steps: for each system index, determining a predicted index value of the system index in a target time period according to an actual index value of the system index in a first auxiliary time period before the target time period by adopting a target network model of the system index; determining a prediction score of the system in the target time period according to the prediction index value of each system index in the target time period and the weight corresponding to each system index; and determining a target operation state from the candidate operation states according to the prediction score and an association relationship between the candidate operation states and the candidate scores. According to the scheme, the prediction index value of each system index is determined according to the ...

On-line monitoring device and system for potential difference of electrode address field domain of grounding electrode

The invention provides an on-line monitoring device and system for a potential difference of an earth electrode address field domain. The on-line monitoring device for the potential difference of the earth electrode address field domain comprises at least one non-polarized electrode and a voltmeter, the non-polarized electrode is buried in a position with a preset depth underground; the voltmeter is electrically connected with the non-polarized electrode, the voltmeter is used for communicating with a battery swap station, and the voltmeter is used for detecting the potential of the non-polarized electrode, determining a contact potential difference or a step potential difference at least according to the potential of the non-polarized electrode, and sending the contact potential difference or the step potential difference to the battery swap station. Therefore, the purpose of automatically detecting the potential difference is achieved, excessive manpower consumption is avoided, and the ...

METHOD, APPARATUS, DEVICE AND COMPUTER READABLE STORAGE MEDIUM FOR RECOGNIZING AND DECODING VOICE BASED ON STREAMING ATTENTION MODEL

A method, apparatus, device, and computer readable storage medium for recognizing and decoding a voice based on a streaming attention model are provided. The method may include generating a plurality of acoustic paths for decoding the voice using the streaming attention model, and then merging acoustic paths with identical last syllables of the plurality of acoustic paths to obtain a plurality of merged acoustic paths. The method may further include selecting a preset number of acoustic paths from the plurality of merged acoustic paths as retained candidate acoustic paths. Embodiments of the present disclosure present a concept that acoustic score calculating of a current voice fragment is only affected by its last voice fragment and has nothing to do with earlier voice history, and merge acoustic paths with the identical last syllables of the plurality of candidate acoustic paths. 1. A method for recognizing and decoding a voice based on a streaming attention model , comprising:generating a plurality of acoustic paths for decoding the voice using the streaming attention model;merging acoustic paths with identical last syllables among the plurality of acoustic paths to obtain a plurality of merging acoustic paths; andselecting a preset number of acoustic paths from the plurality of merging acoustic paths.2. The method according to claim 1 , wherein the generating a plurality of acoustic paths for decoding the voice using the streaming attention model comprises:generating the plurality of acoustic paths based on a candidate acoustic path of a voice prior to the last voice and a plurality of modeling units of the streaming attention model.3. The method according to claim 1 , wherein the generating a plurality of acoustic paths for decoding the voice using the streaming attention model comprises:determining an acoustic model score of each of the plurality of acoustic paths using the streaming attention model;determining a language model score of each of the plurality ...

Mobile phone camera frame and manufacturing method thereof

The invention discloses a mobile phone camera frame and a manufacturing method thereof, which belong to the technical field of manufacturing mobile phone components. The mobile phone camera frame comprises a frame body. A camera window is disposed in the frame body. One end face of the frame body is provided with a chamfer, and the other end face of the frame body is provided with a plurality of buckles. The manufacturing method of the mobile phone camera frame comprises the steps of processing metal bars into a plurality of ring-shaped members through a turning machine tool; processing an inner cavity in the ring-shaped members; processing the shapes of the ring-shaped members and obtaining preliminarily-formed frame members; conducting polishing and electroplating on the preliminarily-formed frame members. The mobile phone camera frame and the manufacturing method thereof are advantageous in that bars with appropriate specification are adopted for processing; processed frames are separated ...

An ultrasonic sugar infiltration method for candied ginger with low carbohydrates

The present invention relates to an ultrasonic sugar infiltration method for candied ginger with low carbohydrates. The method includes the following steps: taking ginger buds, conducting ultrasonic sugar infiltration method instead of the traditional sugar cooking method on the ginger buds previously treated with peeling, shaping and color protecting with the following ultrasonic sugar infiltration conditions: ratio of candied ginger an sugar infiltration liquid, 1:10-1:20 (W/V); ultrasonic sugar infiltration power, 300-420 W; ultrasonic infiltration sugar temperature, 50-70 DEG C; and ultrasonic sugar infiltration time, 60-100 minutes; and then baking and drying the ginger buds to obtain the candied ginger.

Failure rate prediction method of battery pack

The invention provides a failure rate prediction method for a battery pack, and the method comprises the steps: obtaining a battery data list DATA according to a battery working condition curve and num1 to-be-predicted battery packs; according to the DATA, a capacity attenuation group CAPLOSS is obtained; randomly grouping the capacity attenuation in the CAPLOSS to obtain a target capacity attenuation group corresponding to each to-be-predicted battery pack, and obtaining the maximum predicted capacity attenuation corresponding to each to-be-predicted battery pack to obtain a maximum predicted capacity attenuation group; determining the number num3 of predicted capacity attenuation greater than a preset capacity attenuation threshold in the maximum predicted capacity attenuation group; and determining the failure rate (rate = num < 3 >/num1) of the num1 battery packs to be predicted after the battery packs pass through the tpre. Therefore, the error of the predicted capacity attenuation ...

Optimization design method of breaker nozzle

The invention discloses an optimal design method for a nozzle of a circuit breaker, and relates to the technical field of high-voltage circuit breakers. According to the method, the circuit breaker model is constructed, the first airflow density accurate value of the circuit breaker nozzle area is calculated based on the preset circuit breaker nozzle optimization parameter and the preset circuit breaker nozzle parameter constraint, and then the circuit breaker nozzle optimization model is constructed based on the nozzle parameter sample and the first airflow density accurate value. The breaker nozzle optimization model is optimized by taking preset breaker nozzle parameter constraints as constraint conditions and taking maximization of a first airflow density predicted value of a nozzle area as an optimization target, so that optimal nozzle parameters can be quickly determined, optimal design of a breaker nozzle is realized, and the optimal design efficiency of the breaker nozzle is improved ...

AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS

Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET. © KIPO & WIPO 2007 ...

FUSED BICYCLIC SGC STIMULATORS

sGC Stimulators

Abstract Compounds of Formulae I' and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed. j (Jc)p N (JB R. N ,1(JB)N N D \ 2 X2- (JD) jA jD Formula I' Formula I ...

Ultra-narrow line width ring cavity laser based on parallel feedback

The invention provides an ultra-narrow line width ring cavity laser based on parallel feedback, comprising an Erbium-doped optical fiber amplifier (EDFA), an F-P cavity filter, a single mode optical transmission medium, a multi-mode optical transmission medium, a 90:10 coupler and an isolator, wherein the EDFA is in connected series with the F-P cavity filter, the isolator, the multi-mode optical transmission medium and the 90:10 coupler by the single mode optical transmission medium so as to form a ring cavity; and the through end of the 90:10 coupler is connected into the ring cavity, and the coupling end thereof serves as an optical output port. According to the ultra-narrow line width laser of the invention, an optical transmission structure composed of the single mode optical transmission medium and the multi-mode optical transmission medium can be used for compressing the line width with no need of increasing the Erbium-doped optical fiber length, thus the defects of complicated structure ...

Steel plate net cage reinforced concrete column structure and preparation method

The invention discloses a steel plate net cage reinforced concrete column structure and a preparation method, and belongs to the technical field of building engineering reinforcement. A steel plate net is bound at the outer side of a column plastic hinge area, so that the excellent restraint effect can be provided to concrete, and the early falling of the concrete can be prevented to improve the column ductility. The preparation method comprises the specific operation steps of tailoring of the steel plate net, bending of the steel plate net, mounting of the steel plate net and coating of high-performance mortar. The steel plate net cage reinforced concrete column structure can effectively improve the rotating capacity of the column plastic hinge area, enhance the column ductility and improve the concrete working state.

Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors

Enantiomerically pure compound of formula (I) are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

多功能舌刷

A multifunction tongue brush with magnetic material on brush head is disclosed, which can clean oral cavity, remove odor mucus from tongue for generating fresh mucus, and performing magnetotherapy.

ANCHOR MODEL ADAPTATION DEVICE, INTEGRATED CIRCUIT, AV (AUDIO VIDEO) DEVICE, ONLINE SELF-ADAPTATION METHOD, AND PROGRAM THEREFOR

The present invention provides a device that performs online self-adaption of anchor models for an acoustic space, and a method thereof, the anchor models being used for categorization of an AV stream which is performed based on an audio stream in the AV stream. The device divides an input audio stream into audio segments, each being estimated to have a single acoustic feature, and estimates a single probability model for each audio segment. Then, the device performs clustering on the estimated probability models and probability models stored therein, thereby generating a new anchor model. 1. An anchor model adaptation device comprising:a storage unit storing therein a plurality of anchor models each composed of a different set of probability models, each probability model being generated from a sound having a single acoustic feature;an input unit configured to receive an input of an audio stream;a division unit configured to divide the audio stream into a plurality of audio segments, each being estimated to have a single acoustic feature;an estimation unit configured to estimate a probability model for each audio segment; anda clustering unit configured to perform clustering on the probability models constituting the anchor models in the storage unit and the probability models estimated by the estimation unit, and thereby to generate a new anchor model.2. The anchor model adaptation device of claim 1 , whereinthe clustering unit continuously generates new anchor models with use of a tree splitting method until a number of new anchor models reaches a predetermined number, and updates the anchor models in the storage unit with the predetermined number of new anchor models.3. The anchor model adaptation device of claim 2 , whereinwith use of the tree splitting method, the clustering unitgenerates two new model centers based on a center of a model category having a greatest divergence distance, from among one or more model categories,generates, from the model category ...

ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS

Enantiomerically pure compound of formula 1 2. The compound of claim 1 , wherein Ris hydrogen.3. The compound of claim 1 , wherein Y is N.4. The compound of claim 1 , wherein Y is N and Ris hydrogen.5. The compound of claim 1 , wherein Y is CR.6. The compound of claim 1 , wherein Y is CRand Ris H.7. The compound of claim 1 , wherein Ris a furan claim 1 , thiopene claim 1 , pyrrole claim 1 , pyrroline claim 1 , pyrrolidine claim 1 , dioxolane claim 1 , oxazole claim 1 , thiazole claim 1 , imidazole claim 1 , imidazoline claim 1 , imidazolidine claim 1 , pyrazole claim 1 , pyrazoline claim 1 , pyrazolidine claim 1 , isoxazole claim 1 , isothiazole claim 1 , oxadiazole claim 1 , triazole claim 1 , thiadiazole claim 1 , pyran claim 1 , pyridine claim 1 , piperidine claim 1 , dioxane claim 1 , morpholine claim 1 , dithiane claim 1 , thiomorpholine claim 1 , pyridazine claim 1 , pyrimidine claim 1 , pyrazine claim 1 , piperazine claim 1 , triazine claim 1 , trithiane claim 1 , azetidine or phenyl group claim 1 , and each hydrogen in Ris optionally substituted by R.8. The compound of claim 1 , wherein Ris a 7 to 12-membered fused ring heteroaryl group claim 1 , and each hydrogen in Ris optionally substituted by one or more Rgroups.9. The compound of claim 1 , wherein Ris hydrogen.10. The compound of claim 1 , wherein Ris a halogen.12. An enantiomerically pure compound selected from the group consisting of 5-Bromo-3-[(R)-1-(2 claim 1 ,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyrazin-2-ylamine; 5-iodo-3-[(R)1-(2 claim 1 ,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-ylamine; 5-bromo-3-[1(R)-(2 claim 1 ,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-ylamine; 4-{5-Amino-6-[(R)-1-(2 claim 1 ,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyrazin-2-yl}-benzoic acid; (4-{5-Amino-6-[(R)-1-(2 claim 1 ,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyrazin-2-yl}-phenyl)-piperazin-1-yl-methanone; 4-(4-{5-Amino-6-[(R)-1-(2 claim 1 ,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyrazin-2-yl}-benzoyl)-piperazine-1-carboxyl ...

Recombinant Polymerases With Increased Phototolerance

Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties include increased resistance to photodamage, and can also include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template. 1. A composition comprising a recombinant DNA polymerase , which recombinant polymerase comprises an amino acid sequence that is at least 80% identical to SEQ ID NO:1 or at least 80% identical to SEQ ID NO:2 , and which recombinant polymerase comprises one or more mutation selected from the group consisting of an amino acid substitution at position 131 , an amino acid substitution at position 132 , a K135Q substitution , a K135S substitution , an H149D substitution , a Q183F substitution , a G197D substitution , a G197E substitution , an I201E substitution , a K206E substitution , an A437N substitution , and a D510S substitution , wherein identification of positions is relative to SEQ ID NO:1.2. The composition of claim 1 , wherein the recombinant polymerase comprises a K131E substitution or a K131Q substitution claim 1 , wherein identification of positions is relative to SEQ ID NO:1.3. The composition of claim 1 , wherein the recombinant polymerase comprises one or more mutation or combination of mutations selected from the group consisting of an amino acid substitution at position 253 claim 1 , an amino acid substitution at position 375 claim 1 , ...

Portable console, workstation and radiography system

A portable console communicates with a workstation of a radiography apparatus to allow a user to control the radiography apparatus via the portable console, the portable console comprising a user interface representing module configured to provide a user operation interface whereby the user inputs a user request, and configured to present a result returned from the workstation to the user, and a user interface service logical module configured to perform a protocol encapsulation and conversion on the user request according to a predefined communication protocol, to send the user request to the workstation, to receive the result returned from the workstation, and to perform a protocol conversion on the received result before sending the result to the user interface representing module.

Designing a GUI Development Toolkit

Designing a GUI development toolkit includes creating a windows event class with a property of window predefined condition events and a property of window drag and drop events; creating a windows adapter class with two trigger methods; creating a windows class with a window listener method configured to cause the window to enter into an edit mode in response to detecting the property of window predefined condition events is triggered; and to obtain and save initial location, dragged-to location and the mapping relationship between thereof for each component in the window in response to detecting that the property of window drag and drop events is triggered; and creating a component class with an action listener method defined to cause components in a window to be dragged to other locations of the window in which the components are located in response to detecting that the window is under the edit mode. 1. A method for designing a graphical user interface (GUI) development tool , comprising:creating a windows event class, in which a property of window predefined condition events and a property of window drag and drop events are defined;creating a windows adapter class, in which a trigger method of window predefined condition events is defined to trigger the property of window predefined condition events defined in the window event class in response to occurrence of the window predefined condition events; anda trigger method of window drag and drop event is defined to trigger, using a processor, the property of window drag and drop event defined in the windows event class under the edit mode in response to occurrence of the window drag and drop events;creating, using the processor, a windows class, in which a window listener method is created which is configured to cause the window to enter into an edit mode in response to detecting the property of window predefined condition events defined in the windows event class is triggered; and to obtain and save initial ...

CLASSIFICATION OF NUCLEIC ACID TEMPLATES

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid. 1. A method of determining a sequence of a double-stranded nucleic acid sample and a position of at least one modified base in the sequence , comprising:a) locking the forward and reverse strands together to form a circular pairlocked molecule;b) obtaining sequence data of the circular pair-locked molecule via single molecule sequencing, wherein the sequence data comprises sequences of the forward and reverse strands of the circular pair-locked molecule;c) determining the sequence of the double-stranded nucleic acid sample by comparing the sequences of the forward and reverse strands of the circular pair-locked molecule;d) obtaining sequencing data of the circular pair-locked molecule via single molecule sequencing, wherein at least one nucleotide analog that discriminates between a base and its modified form is used to obtain sequence data comprising at least one position wherein the at least one differentially labeled nucleotide analog was incorporated; ande) determining the positions of modified bases in the sequence of the double-stranded nucleic acid sample by comparing the sequences of the forward and reverse strands.2. A method of determining a sequence of a double-stranded nucleic acid sample and a position of at least one modified base in the sequence , comprising:a) locking the forward and reverse strands of the nucleic acid sample together to form a circular pair-locked molecule;b) obtaining sequence data of the circular pair-locked molecule via single molecule sequencing, wherein at least ...

KIF18A INHIBITORS

The present invention relates to chemical compounds having a general formula (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A. 8. The compound according to wherein Ris H or methyl.9. The compound according to wherein each of R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and Ris H claim 1 , halo claim 1 , Calk claim 1 , or Chaloalk; and each of Rand Rpair combine with the carbon atom attached to each of them form a saturated 3- claim 1 , 4- claim 1 , or 5-membered monocyclic ring spiro to the Rring; wherein said ring contains 0 claim 1 , 1 claim 1 , 2 or 3 N atoms and 0 or 1 atoms selected from O and S.10. The compound according to wherein each of R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and Ris H claim 1 , methyl claim 1 , or ethyl; and each of Rand Rpair combine with the carbon atom attached to each of them form a cyclopropyl claim 1 , cyclobutyl claim 1 , or cyclopentyl ring spiro to the Rring.12. The compound according to wherein Z is absent claim 1 , —NH— claim 1 , —NHSO— claim 1 , —O— claim 1 , —SONH— claim 1 , —S(═O)(═NH)— claim 1 , —CH—S(═O)(═NH)— claim 1 , —SO— claim 1 , —CH—SO claim 1 , or CH(CH)—SO.13. The compound according to wherein Ris selected from:a) H;(b) F;{'sub': 1-6', '3', '3', '3', '2, '(c) Calk substituted by 0, 1, 2 or 3 group(s) selected from F, Cl, Br, —CF, —C(═O)CH, —OH, —OCH, —NH, cyclopropyl, cyclopropylmethanol, or 3-(trifluoromethyl)-3H-diazirinyl; or'}{'sub': 3', '1-6', '3', '2, '(d) a saturated, partially-saturated or unsaturated 3-, 4-, 5-, 6-, or 7-membered monocyclic ring containing 0, 1, 2 or 3 N atoms and 0 or 1 atoms selected ...

SINGLE MOLECULE SEQUENCING WITH TWO DISTINCT CHEMISTRY STEPS

Methods, Compositions, and Systems are provided for nucleic acid sequencing where the sequential incorporation of nucleotides uses two distinct chemical steps. A plurality of nucleotide analogs, each having a labeled leaving group at its 3′ hydroxyl can be sequentially added to a growing strand in the presence of a selective cleaving activity that cleaves the 3′ hydroxyl leaving group preferentially after it has been incorporated. The selective cleaving agent can comprise an exonuclease activity, and the exonuclease activity can be a polymerase-associated exonuclease activity. Nucleotide analogs having labels on both a cleavable polyphosphate portion and on a 3′ hydroxyl leaving group can provide signals characteristic of nucleotide analog incorporation. Systems having illumination optics, collection optics, and substrates observe signals from the labels as they are being incorporated into a growing nucleic acid strand, allowing for the sequencing of template nucleic acids. 1. A method of determining the nucleotide sequence of a target nucleic acid sequence , comprising the steps of:(a) providing a reaction complex comprising a template nucleic acid comprising a target nucleic acid sequence, a primer nucleic acid comprising a sequence which is complementary to a region of the template nucleic acid, and a polymerase enzyme or an enzyme complex, which comprises 5′ to 3′ polymerization activity and 3′ to 5′ exonuclease activity;(b) contacting the reaction complex with a plurality of nucleotide analogs, wherein an individual nucleotide analog of said plurality comprises at least one base-pairing moiety, at least one non-complementary nucleotide residue and at least one label moiety comprising a photo-detectable label that is indicative of the identity of the base-pairing moiety;(c) allowing the enzyme or enzyme complex to incorporate a nucleotide analog in a template-dependent manner into a nascent strand via the enzyme's or enzyme complex's 5′ to 3′ polymerization ...

METHOD AND DEVICE FOR RECOGNIZING VOICE

A method for recognizing a voice and a device for recognizing a voice are provided. The method includes: collecting voice information input by a user; extracting characteristics from the voice information to obtain characteristic information; decoding the characteristic information according to an acoustic model and a language model obtained in advance to obtain recognized voice information, wherein the acoustic model is obtained by data compression in advance. 1. A method for recognizing a voice , comprising:collecting voice information input by a user;extracting characteristics from the voice information to obtain characteristic information;decoding the characteristic information according to an acoustic model and a language model obtained in advance to obtain recognized voice information, wherein the acoustic model is obtained by data compression in advance.2. The method according to claim 1 , wherein after obtaining characteristic information claim 1 , the method further comprises:filtering the characteristic information to obtain filtered characteristic information, so as to decode the filtered characteristic information.3. The method according to claim 2 , wherein filtering the characteristic information comprises:performing an extraction of frame skipping on the characteristic information.4. The method according to claim 1 , wherein decoding the characteristic information according to an acoustic model and a language model obtained in advance to obtain recognized voice information comprises:performing a data compression on the characteristic information to obtain compressed characteristic information, and calculating the compressed characteristic information according to the acoustic model that is obtained by the data compression in advance to obtain a score of acoustic model;calculating data after acoustic model scoring according to the language model to obtain a score of language model;obtaining the recognized voice information according to the score of ...

METHOD FOR EXTRACTING URANIUM WITH COUPLING DEVICE OF WIND POWER GENERATION AND URANIUM EXTRACTION FROM SEAWATER

A method for extracting uranium with a coupling device of wind power generation and uranium extraction from seawater includes the following steps: adding oxygen vacancy (OV)-containing InOto absolute ethanol, and subjecting a resulting mixture to stirring and ultrasonic treatment to obtain a solution of InOin absolute ethanol; coating the solution uniformly on carbon cloth, and drying to obtain carbon cloth coated with OV-containing InO; inserting the coated carbon cloth (as a working electrode) and another blank carbon cloth (as a counter electrode) into a plastic carrier of a coupling device; fixing a small wind power generation apparatus above the plastic carrier, and connecting the working electrode and the counter electrode to a storage battery of the apparatus via wires; and placing the coupling device in seawater, and after the storage battery is charged, energizing the working electrode and the counter electrode to extract uranium from the seawater. 1. A method for extracting uranium with a coupling device of wind power generation and uranium extraction from seawater , comprising the following steps:{'sub': 2', '3-x', '2', '3-x, 'step 1, adding oxygen vacancy (OV)-containing InOto absolute ethanol to obtain a first mixture, and subjecting the first mixture to stirring for 0.5 h to 1 h and then to ultrasonic treatment for 0.5 h to 1 h to obtain a solution of InOin absolute ethanol;'}{'sub': 2', '3-x', '2', '3-x, 'step 2, coating the solution of InOin absolute ethanol uniformly on carbon cloth; and after the coating is completed, naturally drying the carbon cloth to obtain carbon cloth coated with OV-containing InO;'}{'sub': 2', '3-x, 'step 3, using the carbon cloth coated with OV-containing InOas a working electrode and blank carbon cloth as a counter electrode; and inserting the working electrode and the counter electrode into a plastic carrier of the coupling device, separately;'}step 4, fixing a small wind power generation apparatus above the plastic ...

SPEECH PROCESSING METHOD AND METHOD FOR GENERATING SPEECH PROCESSING MODEL

The present disclosure provides a speech processing method, and a method for generating a speech processing model, related to a field of signal processing technologies. The speech processing method includes: obtaining M speech signals to be processed and N reference signals; performing sub-band decomposition on each of the M speech signals and each of the N reference signals to obtain frequency-band components in each speech signal and each reference signal; processing the frequency-band components in each speech signal and each reference signal by using an echo cancellation model, to obtain an ideal ratio mask corresponding to the N reference signals in each frequency band of each speech signal; and performing echo cancellation on each frequency-band component of each speech signal based on the ideal ratio mask corresponding to the N reference signals in each frequency band of each speech signal, to obtain M echo-cancelled speech signals. 1. A speech processing method , comprising:obtaining M speech signals to be processed and N reference signals, wherein M and N are positive integers equal to or greater than 1;performing sub-band decomposition on each of the M speech signals and each of the N reference signals to obtain frequency-band components in each speech signal and frequency-band components in each reference signal;processing the frequency-band components in each speech signal and the frequency-band components in each reference signal by using an echo cancellation model, to obtain an ideal ratio mask (IRM) corresponding to the N reference signals in each frequency band of each speech signal; andperforming echo cancellation on each frequency-band component of each speech signal based on the ideal ratio mask corresponding to the N reference signals in each frequency band of each speech signal, to obtain M echo-cancelled speech signals.2. The speech processing method according to claim 1 , wherein performing sub-band decomposition on each of the M speech ...

INTERCALATED SINGLE-CHAIN VARIABLE FRAGMENTS

Single chain antibody polypeptides with engineered peptide bond crossovers in the light chain and/or heavy chain variable domains, compositions comprising the same, and methods of making and using the same are provided. The antibody polypeptides can be intercalated (crossover) single chain variable fragments (scFvs) or any antibody frameworks which comprise such scFvs, such as diabodies, bispecific antibodies or bssFvs. The single chain antibody polypeptides may or may not contain a linker. The single chain antibody polypeptides are useful in applications where standard (conventional) scFvs are useful, such as in the development of scFv libraries for screening, as therapeutic antibodies, or in in vitro and in vivo targeting applications. 29-. (canceled)10: The single chain antibody polypeptide antibody framework of comprising the amino acid sequence of SEQ ID NO: 39.11: An antibody framework comprising the single chain polypeptide antibody framework of claim 1 , wherein the the antibody framework is selected from the group consisting of: a Fab fragment comprising crossovers claim 1 , a F(ab′)fragment comprising crossovers claim 1 , an Fv fragment comprising crossovers claim 1 , a diabody comprising crossovers claim 1 , a minibody comprising crossovers claim 1 , a bispecific antibody comprising crossovers claim 1 , a bispecific single-chain Fvs (bsscFvs) comprising crossovers claim 1 , and a chimeric antigen receptor comprising crossovers.12. (canceled)13: The single antibody polypeptide antibody framework of claim 1 , wherein the polypeptide further comprises a linker of 1 claim 1 , 2 claim 1 , 3 claim 1 , 4 claim 1 , 5 claim 1 , 6 claim 1 , 7 claim 1 , or 8 amino acid residues.14: A nucleic acid encoding the single chain polypeptide antibody framework of .15: A vector comprising the nucleic acid of .16: A host cell comprising the nucleic acid of .17: A host cell expressing the single chain polypeptide antibody framework of .18: A method of making a single chain ...

KIF18A INHIBITORS

The present invention relates to chemical compounds having a general formula (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A. 6. The compound according to wherein Ris H or methyl.7. The compound according to wherein each of R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and Ris H claim 1 , halo claim 1 , Calk claim 1 , or Chaloalk; and each of Rand Rpair combine with the carbon atom attached to each of them form a saturated 3- claim 1 , 4- claim 1 , or 5-membered monocyclic ring spiro to the Rring; wherein said ring contains 0 claim 1 , 1 claim 1 , 2 or 3 N atoms and 0 claim 1 , 1 claim 1 , or 2 atoms selected from O and S.8. The compound according to wherein each of R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and Ris H claim 1 , methyl claim 1 , or ethyl; and each of Rand Rpair combine with the carbon atom attached to each of them form a cyclopropyl claim 1 , cyclobutyl claim 1 , or cyclopentyl ring spiro to the Rring.11. The compound according to wherein Z is absent claim 1 , —NH— claim 1 , —NHSO— claim 1 , —SONH— claim 1 , —S(═O)(═NH)— claim 1 , —S— claim 1 , —S(═O)— claim 1 , —SO— claim 1 , —(C═O)— claim 1 , or —(C═O)NH—.12. The compound according to wherein Ris selected from (a) H; (b) Calk substituted by 0 claim 1 , 1 claim 1 , 2 or 3 group(s) selected from F claim 1 , Cl claim 1 , Br claim 1 , —OH claim 1 , —OCH claim 1 , or cyclopropyl; or (c) a saturated claim 1 , partially-saturated or unsaturated 3- claim 1 , 4- claim 1 , 5- claim 1 , 6- claim 1 , or 7-membered monocyclic ring containing 0 claim 1 , 1 claim 1 , 2 or 3 N atoms and 0 or 1 atoms selected from ...

RECOMBINANT POLYMERASES WITH INCREASED PHOTOTOLERANCE

Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties include increased resistance to photodamage, and can also include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template. 120.-. (canceled)21. A composition comprising a φ29-type (phi29-type) recombinant DNA polymerase , which recombinant polymerase comprises an amino acid sequence that is at least 80% identical to SEQ ID NO:2 , and which recombinant polymerase comprises one or more mutation selected from the group consisting of an amino acid substitution at position D17 , an amino acid substitution at position P305 , a Q96W substitution , a K128S substitution , an R258Q substitution , an K303Q substitution , a C452A substitution , an E463K substitution , an E463R substitution , and an E505Q substitution , wherein identification of positions is relative to SEQ ID NO:2 , and wherein said polymerase exhibits polymerase activity.22. The composition of claim 21 , wherein the recombinant polymerase comprises a P305L substitution claim 21 , wherein identification of positions is relative to SEQ ID NO:2.23. The composition of claim 21 , wherein the recombinant polymerase comprises one or more mutation or combination of mutations selected from the group consisting of an amino acid substitution at position 250 claim 21 , an amino acid substitution at position 372 claim 21 , an ...

SINGLE MOLECULE SEQUENCING WITH TWO DISTINCT CHEMISTRY STEPS

Methods, Compositions, and Systems are provided for nucleic acid sequencing where the sequential incorporation of nucleotides uses two distinct chemical steps. A plurality of nucleotide analogs, each having a labeled leaving group at its 3′ hydroxyl can be sequentially added to a growing strand in the presence of a selective cleaving activity that cleaves the 3′ hydroxyl leaving group preferentially after it has been incorporated. The selective cleaving agent can comprise an exonuclease activity, and the exonuclease activity can be a polymerase-associated exonuclease activity. Nucleotide analogs having labels on both a cleavable polyphosphate portion and on a 3′ hydroxyl leaving group can provide signals characteristic of nucleotide analog incorporation. Systems having illumination optics, collection optics, and substrates observe signals from the labels as they are being incorporated into a growing nucleic acid strand, allowing for the sequencing of template nucleic acids. 187-. (canceled)88. A method for sequencing a nucleic acid template comprising:providing a sequencing mixture comprising (i) a polymerase enzyme, (ii) a template nucleic acid, (iii) a polymerase regent solution having the components for carrying out template directed synthesis of a growing nucleic acid strand including a plurality of types of nucleotide analogs; wherein each type of nucleotide analog has a labeled leaving group that is cleavable by an exonuclease, and each type of nucleotide analog has a different label, wherein the labeled leaving group blocks further nucleotide incorporations at the 3′ hydroxyl position of the nucleotide analog once it is incorporated; and (iv) an exonuclease activity which cleaves a labeled leaving group from an incorporated nucleotide analog;carrying out nucleic acid synthesis such that a plurality of nucleotide analogs are added sequentially whereby: i) a nucleotide analog is incorporated, then ii) the labeled leaving group on that nucleotide analog is ...

METHOD AND APPARATUS FOR VOICE IDENTIFICATION, DEVICE AND COMPUTER READABLE STORAGE MEDIUM

Embodiments of the present disclosure provide a method and apparatus for voice identification, a device and a computer readable storage medium. The method may include: for an inputted voice signal, obtaining a first piece of decoded acoustic information by a first acoustic model and obtaining a second piece of decoded acoustic information by a second acoustic model, where the second acoustic model being generated by joint modeling of acoustic model and language model. The method may further include determining a first group of candidate identification results based on the first piece of decoded acoustic information, determining a second group of candidate identification results based on the second piece of decoded acoustic information, and then determining a final identification result for the voice signal based on the first group of candidate identification results and the second group of candidate identification results. 1. A method for voice identification , comprising:obtaining, for an inputted voice signal, a first piece of decoded acoustic information and a second piece of decoded acoustic information respectively by a first acoustic model and a second acoustic model, the first acoustic model being generated by acoustic modeling and the second acoustic model being generated by joint modeling of acoustic model and language model;determining a first group of candidate identification results and a second group of candidate identification results respectively based on the first piece of decoded acoustic information and the second piece of decoded acoustic information; anddetermining an identification result for the voice signal based on the first group of candidate identification results and the second group of candidate identification results.2. The method according to claim 1 , wherein the first acoustic model is a connectionist temporal classification (CTC) model claim 1 , the second acoustic model is a streaming multi-layer truncated attention (SMLTA) model ...

KIF18A INHIBITORS

Compounds of formula (I): (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A. 5. The compound according to wherein Ris H or methyl.6. The compound according to wherein each of R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and Ris H claim 1 , halo claim 1 , Calk claim 1 , or Chaloalk; and each of Rand Rpair combine with the carbon atom attached to each of them form a saturated 3- claim 1 , 4- claim 1 , or 5-membered monocyclic ring spiro to the Rring; wherein said ring contains 0 claim 1 , 1 claim 1 , 2 or 3 N atoms and 0 or 1 atoms selected from O and S.7. The compound according to wherein each of R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and Ris H claim 1 , methyl claim 1 , or ethyl; and each of Rand Rpair combine with the carbon atom attached to each of them form a cyclopropyl claim 1 , cyclobutyl claim 1 , or cyclopentyl ring spiro to the Rring.10. The compound according to wherein Z is absent claim 1 , NH— claim 1 , —NHSO—(CH)— claim 1 , —N(CH)—SO—(CH)— claim 1 , —NCHSONH claim 1 , —NHSONH—C(═O)—O— claim 1 , —SONH—(CH)— claim 1 , —(CH)—S(═O)(═NH)— claim 1 , —(CH)—S— claim 1 , —(CH)—S(═O)— claim 1 , (CHCH)—S(═O)— claim 1 , —(CH)—SO— claim 1 , —O— claim 1 , —P(═O) claim 1 , —(C═O)— claim 1 , or —NH(C═O).13. The compound according to wherein Ris a group —Z—R claim 1 , wherein Z is —NHSO— or —SONH—; and Ris oxetanyl claim 1 , cyclopropyl claim 1 , or Ris Calk substituted by 0 claim 1 , 1 claim 1 , 2 or 3 OH group(s).14. The compound according to wherein Ris a group —Z—R claim 1 , wherein Z is —NHSO— and Ris —CH—CH—OH.15. The compound according to wherein Ris halo or a ...

METHOD OF REGISTERING ATTRIBUTE IN SPEECH SYNTHESIS MODEL, APPARATUS OF REGISTERING ATTRIBUTE IN SPEECH SYNTHESIS MODEL, ELECTRONIC DEVICE, AND MEDIUM

A method of registering an attribute in a speech synthesis model, an apparatus of registering an attribute in a speech synthesis model, an electronic device, and a medium are provided, which relate to a field of an artificial intelligence technology such as a deep learning and intelligent speech technology. The method includes: acquiring a plurality of data associated with an attribute to be registered; and registering the attribute in the speech synthesis model by using the plurality of data associated with the attribute, wherein the speech synthesis model is trained in advance by using a training data in a training data set. 1. A method of registering an attribute in a speech synthesis model , comprising:acquiring a plurality of data associated with an attribute to be registered; andregistering the attribute in the speech synthesis model by using the plurality of data associated with the attribute, wherein the speech synthesis model is trained in advance by using a training data in a training data set.2. The method according to claim 1 , wherein in response to the attribute containing a tone claim 1 , the acquiring a plurality of data associated with an attribute to be registered comprises:acquiring a plurality of registration data associated with a tone to be registered, wherein each of the plurality of registration data contains a text content, a tone information of the tone to be registered, an audio information of the text content, and a target acoustic feature information using the tone to be registered to describe the text content.3. The method according to claim 2 , wherein the registering the attribute in the speech synthesis model by using the plurality of data associated with the attribute comprises:generating a predicted acoustic feature information by using a content encoder, a style extractor, a tone encoder, and a decoder in the speech synthesis model, based on the text content, the audio information of the text content, and the tone information in ...

Produced water steam generation process using produced water boiler with gas turbine

A method and system for producing steam for use in heavy hydrocarbon recovery operations. Water, containing impurities, produced from the well is separated from hydrocarbons and other materials, and subsequently directly passed to a produced water boiler with online pigging. The boiler is indirectly heated by means of a hot flue gas, such as a gas turbine exhaust, which produces electricity (for powering a central processing facility, or alternatively a burner to heat the boiler) and exhaust heat for heating the boiler.

DISTRIBUTED STEAM GENERATION PROCESS FOR USE IN HYDROCARBON RECOVERY OPERATIONS

A method and system for producing steam for use in heavy hydrocarbon recovery operations. In an arrangement with or without a central processing facility and/or a plurality of well pads in communication with the central processing facility, each well pad is provided with equipment for separation of materials produced from its respective wells, and steam generation equipment for that well pad, thus allowing for simplified piping transport. 1. A method for separating water from materials produced from a subsurface hydrocarbon recovery operation , wherein the operation comprises a central processing facility in fluid communication with at least one well pad , the at least one well pad for servicing at least one related hydrocarbon recovery well , the method comprising the steps of:locating produced materials treatment means at the at least one well pad;producing produced materials from the at least one related hydrocarbon recovery well at the at least one well pad; andtreating the produced materials using the produced materials treatment means to separate water from the produced materials.2. The method of further comprising the step of treating the produced materials using the produced materials treatment means to separate gas and/or solids and/or hydrocarbon from the produced materials.3. The method of claim 2 , wherein the hydrocarbon is separated claim 2 , further comprising the step of transporting the hydrocarbon from the at least one well pad to the central processing facility.4. The method of further comprising the step of partially upgrading the hydrocarbon at the at least one well pad before transporting the hydrocarbon to the central processing facility.5. The method of claim 2 , wherein the gas is separated claim 2 , further comprising the step of treating the gas at the at least one well pad by using gas treating means located at the at least one well pad.6. The method of wherein treating the gas comprises reducing sulphur content of the gas.7. The method ...

METHOD FOR ELECTROCHEMICAL EXTRACTION OF URANIUM FROM SEAWATER USING OXYGEN VACANCY (OV)-CONTAINING METAL OXIDE

A method for electrochemical extraction of uranium from seawater using an oxygen vacancy (OV)-containing metal oxide includes the following steps: adding glycerin to a solution of indium nitrate in isopropanol, transferring a resulting mixture to a reactor, and conducting reaction to obtain a spherical indium hydroxide solid; dissolving the solid in deionized water, transferring a resulting solution to the reactor, and conducting reaction to obtain a flaky indium hydroxide solid; calcining the solid to obtain calcined OV-containing InO; adding the InO; to ethanol, and adding a membrane solution; coating a resulting solution uniformly on carbon paper, and naturally drying the carbon paper; clamping dried carbon paper with a gold electrode for being used as a working electrode for a three-electrode system; and adding simulated seawater to an electrolytic cell, placing the three-electrode system in the simulated seawater, and stirring the simulated seawater for electrolysis to extract uranium from the seawater. 1. A method for an electrochemical extraction of uranium from seawater using an oxygen vacancy (OV)-containing metal oxide , comprising the following steps:step 1, preparing a solution of indium nitrate in isopropanol with a concentration of 0.024 mol/L to 0.028 mol/L, adding glycerin to the solution of indium nitrate in isopropanol to obtain a first mixture, and subjecting the first mixture to stirring for 0.5 h to 1 h and then to ultrasonic treatment for 0.5 h to 1 h to obtain a mixed solution;step 2, transferring the mixed solution to a high-temperature and high-pressure polytetraftuoroethylene (PTFE) reactor, heating the mixed solution to a first temperature of 160° C. to 200° C. and holding at the first temperature for 1 h to 3 h, and naturally cooling to room temperature; and conducting solid-liquid separation (SLS), washing a resulting solid with deionized water and ethanol to obtain a washed solid, and drying the washed solid in a vacuum drying oven at ...

Sgc stimulators

The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) and/or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP) might be desirable. Various compounds are disclosed, including those of Formula (I).

VOICE PROCESSING SYSTEM AND METHOD, ELECTRONIC DEVICE AND READABLE STORAGE MEDIUM

The present application discloses a voice processing system and method, an electronic device and a readable storage medium, which relates to the field of voice processing technologies. The voice processing system includes: a neural-network processing unit (NPU) and an RISC-V processor; wherein the RISC-V processor includes predefined NPU instructions, and the RISC-V processor is configured to send the NPU instructions to the NPU to cause the NPU to perform corresponding neural network computation; the NPU includes a memory unit and a computing unit, and the memory unit includes a plurality of storage groups; the computing unit is configured to execute one of main computation, special computation, auxiliary computation and complex instruction set computing (CISC) control according to the received NPU instructions. 1. A voice processing system , comprising:a neural-network processing unit (NPU) and an RISC-V processor;wherein the RISC-V processor comprises predefined NPU instructions, the RISC-V processor is configured to send the NPU instructions to the NPU to cause the NPU to perform corresponding neural network computation;the NPU comprises a memory unit and a computing unit, and the memory unit comprises a plurality of storage groups; the computing unit is configured to execute one of main computation, special computation, auxiliary computation and complex instruction set computer (CISC) control according to the received NPU instructions.2. The voice processing system according to claim 1 , wherein the predefined NPU instructions comprise basic vector operation instructions and instructions dedicated to the neural network computation.3. The voice processing system according to claim 1 , wherein the plurality of storage groups comprised in the memory unit are configured to store model parameter data of a neural network and intermediate data generated in a model computation process of the neural network respectively.4. The voice processing system according to claim ...

METHOD, APPARATUS, DEVICE AND COMPUTER STORAGE MEDIUM FOR GENERATING SPEECH PACKET

A method, device and computer storage medium for generating a speech packet which relates to the technical field of speech are disclosed. The method may include: providing a speech recording interface to a user; obtaining speech data entered by the user after obtaining an event of triggering speech recording on the speech recording interface; uploading the speech data to a server side in response to determining that the speech data meets requirements for training a speech synthesis model; receiving a downloading address of the speech packet generated by the server side after training the speech synthesis model with the speech data. An ordinary user may customize a personalized speech packet through the speech recording interface provided by the client, without using professional recording equipment, which may substantially reduce the production cost of the speech packet. 1. A method for generating a speech packet , implemented in a client , wherein the method comprises:providing a speech recording interface to a user;obtaining speech data entered by the user after obtaining an event of triggering speech recording on the speech recording interface;uploading the speech data entered by the user to a server side in response to determining that the speech data entered by the user meets requirements for training a speech synthesis model; andreceiving a downloading address of the speech packet generated by the server side after training the speech synthesis model with the speech data.2. The method according to claim 1 , wherein the event of triggering speech recording comprises at least one of:detecting a gesture of triggering speech recording on the speech recording interface; orreceiving a speech instruction of triggering speech recording from the user when the speech recording interface is displayed.3. The method according to claim 1 , wherein the obtaining speech data entered by the user comprises:displaying on the speech recording interface a preset text sentence and/ ...

THIN FILM TRANSISTOR ASSEMBLY, ARRAY SUBSTRATE AND DISPLAY PANEL

Embodiments of the present disclosure provide a thin film transistor assembly, an array substrate and a display panel. The thin film transistor assembly includes a first thin film transistor and a second thin film transistor disposed on a substrate. The first thin film transistor includes a first source electrode, a first drain electrode, and a first active layer. The second thin film transistor includes a second source electrode. The first source electrode is disposed on a side of the first active layer facing towards the substrate. The first drain electrode is disposed on a side of the first active layer facing away from the substrate. An orthogonal projection of the first source electrode on the substrate overlaps an orthogonal projection of the second source electrode on the substrate. 1. A thin film transistor assembly comprising:a first thin film transistor and a second thin film transistor disposed on a substrate, the first thin film transistor comprises a first source electrode, a first drain electrode, and a first active layer, and the second thin film transistor comprises a second source electrode,', 'the first source electrode is disposed on a side of the first active layer facing towards the substrate,', 'the first drain electrode is disposed on a side of the first active layer facing away from the substrate, and', 'an orthogonal projection of the first source electrode on the substrate overlaps an orthogonal projection of the second source electrode on the substrate., 'wherein2. The thin film transistor assembly of claim 1 , wherein:the orthogonal projection of the second source electrode on the substrate covers the orthogonal projection of the first source electrode on the substrate.3. The thin film transistor assembly of claim 1 , wherein:the second thin film transistor further comprises a second drain electrode, and the second source electrode and the second drain electrode are disposed in a same layer as the first drain electrode.4. The thin film ...

TRAINING METHOD AND APPARATUS FOR A SPEECH SYNTHESIS MODEL, AND STORAGE MEDIUM

The present application discloses a training method and an apparatus for a speech synthesis model, electronic device, and storage medium. The method includes: taking a syllable input sequence, a phoneme input sequence and a Chinese character input sequence of a current sample as inputs of an encoder of a model to be trained, to obtain encoded representations of these three sequences at an output end of the encoder; fusing the encoded representations of these three sequences, to obtain a weighted combination of these three sequences; taking the weighted combination as an input of an attention module, to obtain a weighted average of the weighted combination at each moment at an output end of the attention module; taking the weighted average as an input of a decoder of the model to be trained, to obtain a speech Mel spectrum of the current sample at an output end of the decoder. 1. A training method for a speech synthesis model , comprising:taking a syllable input sequence, a phoneme input sequence and a Chinese character input sequence of a current sample as inputs of an encoder of a model to be trained, to obtain encoded representations of the syllable input sequence, the phoneme input sequence and the Chinese character input sequence at an output end of the encoder;fusing the encoded representations of the syllable input sequence, the phoneme input sequence and the Chinese character input sequence, to obtain a weighted combination of the syllable input sequence, the phoneme input sequence and the Chinese character input sequence;taking the weighted combination of the syllable input sequence, the phoneme input sequence and the Chinese character input sequence as an input of an attention module, to obtain a weighted average of the weighted combination of the syllable input sequence, the phoneme input sequence and the Chinese character input sequence at each moment at an output end of the attention module; andtaking the weighted average of the weighted combination of ...

METHOD AND APPARATUS FOR ALLOCATING MEMORY AND ELECTRONIC DEVICE

The disclosure provides a method and an apparatus for allocating memory, and an electronic device. Multiple frames of speech data are received and input to a neural network model. The neural network model is configured to ask for multiple data tensors when processing the multiple frames of speech data, and the multiple data tensors share a common memory. 1. A method for allocating memory , comprising:receiving multiple frames of speech data; andinputting the multiple frames of speech data to a neural network model, wherein the neural network model is configured to ask for multiple data tensors while processing the multiple frames of speech data and the multiple data tensors share a common memory.2. The method of claim 1 , further comprising:allocating a memory amount for the common memory based on the number of frames of current speech data.3. The method of claim 2 , wherein allocating the memory amount for the common memory based on the number of frames of the current speech data comprises:allocating the memory amount for the common memory in a first allocation mode based on the current speech data being first-frame speech data; andallocating the memory amount for the common memory in a second allocation mode based on the current speech data being not the first-frame speech data.4. The method of claim 3 , wherein claim 3 , allocating the memory amount for the common memory in the first allocation mode comprises:obtaining a memory amount occupied by each of the multiple data tensors asked for when the neural network model processes a single frame of speech data;selecting two first target data tensors from the multiple data tensors based on the memory amount occupied by each of the data tensors;obtaining memories occupied by the two first target data tensors; andallocating the memory amount for the common memory based on the memories occupied by the two first target data tensors.5. The method of claim 3 , wherein allocating the memory amount for the common memory in ...

INTERACTIVE VOICE-CONTROL METHOD AND APPARATUS, DEVICE AND MEDIUM

The present disclosure discloses an interactive voice-control method and apparatus, a device and a medium. The method includes: obtaining a sound signal at a voice interaction device and recognized information that is recognized from the sound signal; determining an interaction confidence of the sound signal based at least on at least one of an acoustic feature representation of the sound signal and a semantic feature representation associated with the recognized information; determining a matching status between the recognized information and the sound signal; and providing the interaction confidence and the matching status for controlling a response of the voice interaction device to the sound signal. 1. An interactive voice-control method , comprising:obtaining a sound signal at a voice interaction device and recognized information that is recognized from the sound signal;determining an interaction confidence of the sound signal based at least on at least one of an acoustic feature representation of the sound signal and a semantic feature representation associated with the recognized information;determining a matching status between the recognized information and the sound signal; andproviding the interaction confidence and the matching status for controlling a response of the voice interaction device to the sound signal.2. The method of claim 1 , wherein determining the interaction confidence comprises: extracting the acoustic feature representation of the sound signal, and', 'determining an acoustic confidence that the sound signal indicates speech for human-machine interaction, based on the acoustic feature representation; and, 'executing one or more of the following operations by using an acoustic confidence modeldetermining the interaction confidence based on at least one of the acoustic feature representation and the acoustic confidence by using a fusion model.3. The method of claim 2 , wherein the acoustic confidence model is trained based on a first ...

METHOD, APPARATUS, DEVICE AND COMPUTER-READABLE STORAGE MEDIUM FOR VOICE INTERACTION

According to embodiments of the present disclosure, a method, apparatus, device, and computer readable storage medium for voice interaction are provided. The method includes: determining a text corresponding to the voice signal based on a voice feature of a received voice signal. The method further includes: determining, based on the voice feature and the text, a matching degree between a reference voice feature of an element in the text and a target voice feature of the element. The method further includes: determining a first possibility that the voice signal is an executable command based on the text. The method further includes: determining a second possibility that the voice signal is the executable command based on the voice feature. 1. A method for voice interaction , comprising:determining, based on a voice feature of a received voice signal, a text corresponding to the voice signal;determining, based on the voice feature and the determined text, a matching degree between a reference voice feature of an element in the text and a target voice feature of the element in the voice feature;determining, based on the text, a first possibility that the voice signal is an executable command;determining, based on the voice feature, a second possibility that the voice signal is the executable command; anddetermining, based on the matching degree, the first possibility, and the second possibility, information related to processing of the voice signal.2. The method according to claim 1 , wherein determining the matching degree comprises:determining, from the voice feature, the reference voice feature corresponding to the element in the text; anddetermining the matching degree based on the reference voice feature and the target voice feature of the element.3. The method according to claim 1 , wherein determining information related to processing of the voice signal comprises:determining whether the voice signal is the executable command, based on the matching degree, the ...

GRAMMAR COMPILING METHODS, SEMANTIC PARSING METHODS, DEVICES, COMPUTER STORAGE MEDIA, AND APPARATUSES

A corresponding grammar description file and a word category description file are defined based on a logical grammar by manifest language LGML according to a common sentence expression of a semantic meaning, in the grammar description file, the description for a common sentence is composed by operators, word categories, and functions, the word category description file is used to describe specific values for the word categories; the grammar description file and the word category description file are generated, with a reduction method according to a defined sequence, into a grammar tree for the grammar description file and word category trees for the word category description file; the word category trees are grafted at the positions of corresponding word categories on the grammar tree, forming a grammar tree for the semantic meaning, in this way, grammar compiling is accomplished. Based on the grammar tree of a semantic meaning with aforementioned ways, semantic parsing is carried out with whole-sentence matching, semantic mapping matching, or a combination of whole-sentence matching and semantic mapping matching. 1. A grammar compiling method , wherein the method defines a corresponding grammar description file and a corresponding word category description file based on a logical grammar by manifest language LGML according to a common sentence expression of a semantic meaning , in the grammar description file , the description for a common sentence is composed by operators , word categories , and functions , the word category description file is used to describe specific values for the word categories;the grammar description file and the word category description file are respectively generated, with a reduction method according to a defined sequence, into a grammar tree for the grammar description file and word category trees for the word category description file; andthe word category trees are grafted at the positions of corresponding word categories on the ...

VOICEPRINT LOGIN METHOD AND APPARATUS BASED ON ARTIFICIAL INTELLIGENCE

Disclosed is a voiceprint login method based on artificial intelligence. The method includes: S1: receiving a login request from a user and acquiring user information of the user; S2: generating a login string and replacing at least one character of the login string according to character replacement reference information corresponding to the user information; S3: providing the login string after replacement to the user and receiving speech information of the user reading the login string; and S4: performing a login authentication on the user according to speech information of the user reading the login string. With the method, by using the voiceprint authentication method combining the voiceprint and the character replacement reference information set by the user, the safety of the voiceprint password is increased, and some characters are hidden according the user's preferences, which satisfies the user's psychological demand of not wishing the password to be displayed explicitly. 1. A computer-implemented voiceprint login method based on artificial intelligence , comprising:receiving, at one or more computing devices, a login request of a user, and obtaining, at the one or more computing devices, user information of the user;generating, at the one or more computing devices, a login string, and replacing, at the one or more computing devices, at least one character of the login string according to character replacement reference information corresponding to the user information;providing, at the one or more computing devices, the login string after replacement to the user, and receiving, at the one or more computing devices, speech information of the user reading the login string; andperforming, at the one or more computing devices, a login authentication on the user according to the speech information of the user reading the login string.2. The method according to claim 1 , wherein performing claim 1 , at the one or more computing devices claim 1 , a login ...

RECOMBINANT POLYMERASES WITH INCREASED PHOTOTOLERANCE

Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties include increased resistance to photodamage, and can also include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template. 120-. (canceled)21. A composition comprising a ϕ29-type (phi29-type) recombinant DNA polymerase , which recombinant polymerase comprises an amino acid sequence that is at least 80% identical to SEQ ID NO:1 , and which recombinant polymerase comprises one or more mutation selected from the group consisting of an amino acid substitution at position S10 , an amino acid substitution at position E244 , an amino acid substitution at position A444 , an amino acid substitution at position I460 , a T231S substitution , a K361R substitution , a T573E substitution , a T573G substitution , and a T573S substitution , wherein identification of positions is relative to SEQ ID NO:1 , and wherein said polymerase exhibits polymerase activity.22. The composition of claim 21 , wherein the recombinant polymerase comprises one or more mutation selected from the group consisting of an S10V substitution claim 21 , an E244K substitution claim 21 , an E244Q substitution claim 21 , an E244R substitution claim 21 , an A444G substitution claim 21 , an A444L substitution claim 21 , an A444S substitution claim 21 , an A444V substitution claim 21 , an 1460F substitution claim 21 , ...

Speech recognition method, device, and computer-readable storage medium

The disclosure provides a speech recognition method, a device and a computer-readable storage medium. The method includes obtaining a first voice signal collected from a first microphone in a microphone array and a second voice signal collected from a second microphone in the microphone array, the microphone array including at least two microphones, such as two, three or six microphones. The method further includes extracting enhanced features associated with the first voice signal and the second voice signal through a neural network, and obtaining a speech recognition result based on the enhanced features extracted.

METHOD AND APPARATUS FOR VOICE INTERACTION, DEVICE AND COMPUTER READABLE STORATE MEDIUM

A method, apparatus, device, and storage medium for voice interaction. A specific embodiment of the method includes: extracting an acoustic feature from received voice data, the acoustic feature indicating a short-term amplitude spectrum characteristic of the voice data; applying the acoustic feature to a type recognition model to determine an intention type of the voice data, the intention type being one of an interaction intention type and a non-interaction intention type, and the type recognition model being constructed based on the acoustic feature of training voice data; and performing an interaction operation indicated by the voice data, based on determining that the intention type is the interaction intention type. 1. A method for voice interaction , the method comprising:extracting an acoustic feature from received voice data, the acoustic feature indicating a short-term amplitude spectrum characteristic of the voice data;applying the acoustic feature to a type recognition model to determine an intention type of the voice data, the intention type being one of an interaction intention type and a non-interaction intention type, and the type recognition model being constructed based on acoustic feature of training voice data; andperforming, based on determining that the intention type is the interaction intention type, an interaction operation indicated by the voice data.2. The method according to claim 1 , further comprising:labeling the training voice data, the labeled training voice data being positive training voice data indicating an interaction intention or negative training voice data indicating a non-interaction intention; andconstructing the type recognition model by using the labeled training voice data.3. The method according to claim 2 , wherein the labeling the training voice data comprises:labeling the training voice data as the positive training voice data, based on determining at least one of:semantics of the training voice data is correctly ...

PARTIAL UPGRADING SYSTEM AND METHOD FOR HEAVY HYDROCARBONS

Systems and methods for partially upgrading a produced heavy hydrocarbon resource at the production site (at the pad or a central processing facility) using indirect hydrogen addition, comprising a blender for blending the hydrocarbon with a hydrogen donator and a reactor for elevating the mixture to a temperature sufficient to hydrogenate the hydrocarbon to an API level required for pipeline specifications. The partially upgraded hydrocarbon can then be transported by pipeline to a refinery for further processing. The presence of catalysts and on-site hydrogen production equipment conventionally required for upgrading is eliminated. Further, the need for diluent which is conventionally used to enable pipeline ability of produced heavy hydrocarbon is reduced or eliminated, thus reducing the diluent freight cost and the required pipeline volume. 1. A system for partially upgrading a produced heavy hydrocarbon , the system comprising:a first source for supplying the heavy hydrocarbon;a second source for supplying a hydrogen donator;blending means for blending the heavy hydrocarbon and the hydrogen donator to form a mixture; andheating means for heating the mixture to a temperature necessary to liberate hydrogen molecules from the hydrogen donator and allow the hydrogen molecules to bond with the heavy hydrocarbon, resulting in a partially hydrogenated heavy hydrocarbon.2. The system of further comprising cooling means for cooling the partially hydrogenated heavy hydrocarbon.3. The system of wherein the heavy hydrocarbon has a viscosity above pipeline specifications and the partially hydrogenated heavy hydrocarbon has a viscosity within the pipeline specifications.4. The system of wherein the heavy hydrocarbon is bitumen.5. The system of wherein the hydrogen donator is prepared from a material that has the ability to take up hydrogen in a hydrocracking zone and to readily release it to a hydrogen-deficient heavy hydrocarbon under thermal conditions in the absence of a ...

CLASSIFICATION OF NUCLEIC ACID TEMPLATES

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid. 171-. (canceled)72. A method of identifying a barcode , the method comprising:a) providing a sequencing template comprising a nucleic acid linked to a barcode, wherein the barcode consists of a nucleotide sequence comprising a base modification;b) subjecting the sequencing template to a single-molecule sequencing reaction;c) collecting reaction data in real time during the single-molecule sequencing reaction, wherein said reaction data comprises a sequence read for the sequencing template, and wherein the reaction data further comprises a kinetic change in the single-molecule sequencing reaction, wherein the kinetic change is indicative of the base modification in the nucleotide sequence of the barcode; andd) analyzing both the sequence read and the kinetic change in the reaction data to detect the nucleotide sequence of the barcode, thereby identifying the barcode in the sequencing template.73. The method of claim 72 , wherein the sequencing template comprises a first polynucleotide region and a second polynucleotide region complementary to the first polynucleotide region claim 72 , where the first polynucleotide region and the second polynucleotide region are on a single strand of the sequencing template.74. The method of claim 72 , wherein the sequencing template is subjected to a treatment to alter the modified base prior to the single-molecule sequencing reaction.75. The method of claim 72 , wherein the single-molecule sequencing reaction comprises a polymerase enzyme.76. The method of claim 72 , ...

NEURAL NETWORK PROCESSING UNIT, NEURAL NETWORK PROCESSING METHOD AND DEVICE

A neural network processing method, a neural network processing unit (NPU) and a processing device are provided. The method includes: obtaining by a quantizing unit in the NPU float type input data, quantizing the float type input data to obtain quantized input data, and providing the quantized input data to an operation unit; performing by the operation unit of the NPU a matrix-vector operation and/or a convolution operation to the quantized input data to obtain an operation result of the quantized input data; and performing by the quantizing unit inverse quantization to the operation result output by the operation unit to obtain an inverse quantization result. 1. A neural network processing unit (NPU) , comprising: a quantizing unit and an operation unit; wherein ,the quantizing unit is configured to obtain float type input data; quantize the float type input data to obtain quantized input data; provide the quantized input data to the operation unit to obtain an operation result; and perform inverse quantization to the operation result output by the operation unit to obtain an inverse quantization result; andthe operation unit is configured to perform at least of a matrix-vector operation and a convolution operation to the quantized input data to obtain the operation result of the quantized input data.2. The NPU of claim 1 , wherein when the operation unit is configured to perform the matrix-vector operation claim 1 , the quantizing unit is configured to:obtain a first parameter for quantization and a second parameter for inverse quantization, based on the float type input data stored in a memory of a digital signal processor (DSP);obtain a multiplied value by multiplying a float value to be quantized in the float type input data by the first parameter, and round the multiplied value into a numerical value to obtain numerical input data;send the numerical input data to the operation unit;convert the operation result obtained by the operation unit into a float type ...

INTERCALATED SINGLE-CHAIN VARIABLE FRAGMENTS

Single chain antibody polypeptides with engineered peptide bond crossovers in the light chain and/or heavy chain variable domains, compositions comprising the same, and methods of making and using the same are provided. The antibody polypeptides can be intercalated (crossover) single chain variable fragments (scFvs) or any antibody frameworks which comprise such scFvs, such as diabodies, bispecific antibodies or bssFvs. The single chain antibody polypeptides may or may not contain a linker. The single chain antibody polypeptides are useful in applications where standard (conventional) scFvs are useful, such as in the development of scFv libraries for screening, as therapeutic antibodies, or in in vitro and in vivo targeting applications. 1. A single chain antibody polypeptide comprising a heavy chain variable domain and a light chain variable domain , wherein the antibody polypeptide comprises at least one interdomain crossover , at least one intradomain crossover , or at least one intradomain crossover and at least one interdomain crossover , wherein each crossover is an engineered peptide bond producing an intercalated structure (arrangement or organization) selected from the group consisting of:a) at least one portion of the heavy chain variable domain intercalated (inserted) into the light chain variable domain;b) at least one portion of the light chain variable domain intercalated (inserted) into the heavy chain variable domain;c) at least one portion of the light chain variable domain intercalated (inserted) into a different portion of the light chain variable domain; and,d) at least one portion of the heavy chain variable domain intercalated (inserted) into a different portion of the heavy chain variable domain.2. The single chain antibody polypeptide of claim 1 , comprising at least one intradomain crossover and at least one interdomain crossover.3. The single chain antibody polypeptide of claim 1 , comprising at least two intradomain crossovers.4. The ...

Method and Apparatus For Training Speech Spectrum Generation Model, and Electronic Device

The present application discloses a method and an apparatus for training a speech spectrum generation model, as well as an electronic device, and relates to the technical field of speech synthesis and deep learning. A specific implementation is as follows: inputting a first text sequence into the speech spectrum generation model to generate an analog spectrum sequence corresponding to the first text sequence, and obtain a first loss value of the analog spectrum sequence according to a preset loss function; inputting the analog spectrum sequence corresponding to the first text sequence into an adversarial loss function model, which is a generative adversarial network model, to obtain a second loss value of the analog spectrum sequence; and training the speech spectrum generation model based on the first loss value and the second loss value. 1. A method for training a speech spectrum generation model , the method comprising:inputting a first text sequence into the speech spectrum generation model to generate an analog spectrum sequence corresponding to the first text sequence, and to obtain a first loss value of the analog spectrum sequence according to a preset loss function;inputting the analog spectrum sequence corresponding to the first text sequence into an adversarial loss function model, which is a generative adversarial network model, to obtain a second loss value of the analog spectrum sequence; andtraining the speech spectrum generation model based on the first loss value and the second loss value.2. The method according to claim 1 , wherein prior to inputting the analog spectrum sequence corresponding to the first text sequence into the adversarial loss function model to obtain the second loss value of the analog spectrum sequence claim 1 , the method further comprises:obtaining a real spectrum sequence corresponding to a second text sequence, and an analog spectrum sequence corresponding to the second text sequence, which is generated by the speech ...

METHOD FOR PRODUCING SILENCING DEVICE, SILENCING DEVICE AND AIR PURIFIER

A silencing device, an air purifier, and a method for producing the same are provided. The method includes that: a sound wave spectrum when an air purifier to be silenced performs operations is acquired; a frequency value, which exceeds a sound wave frequency limit for the air purifier, of the sound wave spectrum is calculated; and a silencing device adapted to the air purifier to be silenced is produced according to the frequency value. At least one structural parameter of the silencing device is configured according to the frequency value. The silencing device is configured to reduce a sound with the frequency value exceeding the sound wave frequency limit. 1. A method for producing a silencing device , comprising:acquiring a sound wave spectrum when an air purifier to be silenced performs operations;calculating a frequency value within the sound wave spectrum, which exceeds a sound wave frequency limit for the air purifier; andproducing a silencing device adapted to the air purifier according to the frequency value, wherein at least one structural parameter of the silencing device is configured according to the frequency value, and wherein the silencing device is configured to reduce a sound with the frequency value exceeding the sound wave frequency limit.2. The method of claim 1 , wherein the silencing device comprises a sound insulation mesh plate and silencing cotton attached to the sound insulation mesh plate claim 1 , and a plurality of meshes are in the sound insulation mesh plate; a sound wave frequency f absorbed by the silencing device is equal to the frequency value; andthe at least one structural parameter of the silencing device comprises a mesh area of the sound insulation mesh plate, a silencing cotton volume corresponding to each mesh and a depth of each mesh.4. The method of claim 3 , wherein the mesh area A is ranged from 0.0625 πmmto 100 πmm claim 3 , the depth L of each mesh is ranged from 0.2 mm to 5 mm claim 3 , and a thickness of the ...

PROTECTED DATA SHARING BETWEEN ADVERTISERS AND PUBLISHERS

Methods, computer systems, and computer-storage media are provided for facilitating the exchange of meaningful information between an advertiser and an advertisement publisher in a protected manner using common identifiers (IDs). A third-party agency service receives user advertiser IDs from the advertiser and user publisher IDs from the advertisement publisher and, for each user, maps a user's advertiser ID to its corresponding publisher ID. The third-party agency service assigns a common ID to each mapped pair and communicates the common IDs to the advertiser and the advertisement publisher. Using the common IDs, the advertiser is able to directly request online behavior data for different consumer buying segments from the advertisement publisher. In turn, the advertisement publisher utilizes the common IDs to directly communicate the request results back to the advertiser. 1. One or more computer-storage media having computer-executable instructions embodied thereon that , when executed by one or more computing devices , perform a method of facilitating the exchange of information between an advertiser and an advertisement publisher in a protected manner using common identifiers (ID) , the method comprising: receiving one or more sets of user data from an advertiser, each set of the one or more sets of user data being associated with a user having an advertising ID;', 'receiving one or more sets of user data from an advertisement publisher, each set of the one or more sets of user data being associated with a user having a publisher ID;', 'mapping at least one advertising ID to at least one publisher ID, the at least one advertising ID and the at least one publisher ID being associated with a first user;', 'assigning a common ID to the first user; and', 'communicating the common ID associated with the first user to the advertiser and to the advertisement publisher., 'at a third-party agency service2. The media of claim 1 , wherein the advertising ID uniquely ...

PYRAZOLE DERIVATIVES AS SGC STIMULATORS

Compounds are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed. 2. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , and one or more excipients.3. A method of treating a disease claim 1 , health condition or disorder in a subject in need of treatment claim 1 , comprising administering a therapeutically effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , to the subject in need of treatment claim 1 , wherein the disease claim 1 , health condition or disorder is selected from:disorders related to high blood pressure and decreased coronary blood flow; increased acute and chronic coronary blood pressure; arterial hypertension; vascular disorder resulting from cardiac and renal complications; vascular disorders resulting from heart disease, stroke, cerebral ischemia or renal failure; resistant hypertension; diabetic hypertension; essential hypertension; secondary hypertension; gestational hypertension; pre-eclampsia; portal hypertension; myocardial infarction;heart failure, HFPEF, HFREF; acute and chronic HF; more specific forms of HF: acute decompensated HF, right ventricular failure, left ventricular failure, total HF, ischemic cardiomyopathy, dilated cardiomyopathy, congenital heart defects, HF with valve defects, mitral valve stenosis, mitral valve insufficiency, aortic valve stenosis, aortic valve insufficiency, tricuspid stenosis, tricuspic insufficiency, pulmonary valve stenosis, pulmonary valve insufficiency, combined valvular defects; diabetic heart failure; alcoholic cardiomyopathy or storage cardiomyopathies; diastolic HF, systolic HF; acute phases of an existing chronic HF (worsening HF); diastolic or systolic dysfunction; coronary insufficiency; arrhythmias; reduction of ...

Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors

Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

SEMICONDUCTOR DEVICE AND RELATED MANUFACTURING METHOD

A semiconductor device may include a substrate, a p-channel device, and an n-channel device. The p-channel device may include a first metal member, a first dielectric layer positioned between the substrate and the first metal member, a first barrier layer positioned between the first dielectric layer and the first metal member, a first first-type work function layer directly contacting the first barrier layer and positioned between the first barrier layer and the first metal member, and a first second-type work function layer directly contacting both the first first-type work function layer and the first metal member. The n-channel device may include a second metal member, a second dielectric layer positioned between the substrate and the second metal member, and a second second-type work function layer directly contacting both the second dielectric layer and the second metal member. 1. A semiconductor device comprising:a substrate;a first p-channel device, which comprises: a first metal member, a first dielectric layer positioned between the substrate and the first metal member, a first barrier layer positioned between the first dielectric layer and the first metal member, a first first-type work function layer directly contacting the first barrier layer and positioned between the first barrier layer and the first metal member, and a first second-type work function layer directly contacting both the first first-type work function layer and the first metal member and positioned between the first first-type work function layer and the first metal member; anda first n-channel device, which comprises: a second metal member, a second dielectric layer positioned between the substrate and the second metal member, and a second second-type work function layer directly contacting both the second dielectric layer and the second metal member and positioned between the second dielectric layer and the second metal member.2. The semiconductor device of comprising:a second p- ...

METHOD AND APPARATUS FOR RECOGNIZING VOICE

A method and an apparatus for recognizing a voice are provided. The method may include: inputting a target voice into a pre-trained voice recognition model to obtain an initial text output by at least one recognition network in the voice recognition model, the recognition network including a plurality of preset types of processing layers, and at least one type of processing layer of the recognition network being obtained by training based on a voice sample in a preset direction interval; and determining a voice recognition result of the target voice, based on the initial text. 1. A method for recognizing a voice , the method comprising:inputting a target voice into a pre-trained voice recognition model to obtain an initial text output by at least one recognition network in the voice recognition model, the recognition network comprising a plurality of preset types of processing layers, and at least one type of processing layer of the recognition network being obtained by training based on a voice sample in a preset direction interval; anddetermining a voice recognition result of the target voice, based on the initial text.2. The method according to claim 1 , wherein in response to the voice recognition model being a first voice recognition model claim 1 , the at least one recognition network is one recognition network.3. The method according to claim 2 , wherein the first voice recognition model further comprises a Fourier transform network;the inputting a target voice into a pre-trained voice recognition model to obtain an initial text output by at least one recognition network in the voice recognition model, comprises:inputting the target voice into a pre-trained first voice recognition model, and performing Fourier transform on the target voice using the Fourier transform network to obtain a transformed voice;predicting a text corresponding to the transformed voice using the one recognition network to obtain the initial text; andthe determining a voice recognition ...

Recombinant Polymerases With Increased Phototolerance

Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties include increased resistance to photodamage, and can also include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template. 124.-. (canceled)25. A composition comprising a φ29-type recombinant DNA polymerase , which recombinant polymerase comprises an amino acid sequence that is at least 80% identical to SEQ ID NO:1 , and which recombinant polymerase comprises one or more mutation selected from the group consisting of an amino acid substitution at position E20 , an amino acid substitution at position R308 , a Q99W substitution , a K131S substitution , an R261Q substitution , a C290F substitution , an R306Q substitution , a C455A substitution , an E466K substitution , an E466R substitution , and an E508Q substitution , wherein identification of positions is relative to SEQ ID NO:1 , and wherein said polymerase exhibits polymerase activity.26. The composition of claim 25 , wherein the recombinant polymerase comprises an E20D substitution or an R308L substitution claim 25 , wherein identification of positions is relative to SEQ ID NO:1.27253375484512510148224239250437235515141142504508513523536539205472437253508510. The composition of claim 25 , wherein the recombinant polymerase comprises one or more mutation or combination of mutations selected from the group consisting of ...

Method for non-destructive analysis of multiple structural parameters

A system and method for non-destructive analysis of a structure. A probe acquires a transient time based reference signal and at least one test signal. The reference signal and test signals are transformed to the frequency domain. The frequency domain test signal can be normalized using the frequency domain reference signal. Parameters of interest are evaluated at each test location by iteratively determining estimated parameter values, generating an estimated frequency domain test signal using the estimated parameter values and determining the convergence between the estimated frequency domain test signal and the normalized frequency domain test signal. The parameters values are determined as the estimated parameter values resulting in a maximized convergence between the estimated signal and the normalized test signal. The parameter values can be used to visualize and model various features of the structure.

MICROCHANNEL HEAT EXCHANGER STRUCTURE WITH NOZZLE AND WORKING METHOD THEREOF

A microchannel heat exchanger structure with a nozzle and a working method thereof. The microchannel heat exchanger structure with a nozzle, includes a first heat exchange portion, a second heat exchange portion, and at least one nozzle portion between the first heat exchange portion and the second heat exchange portion, the first heat exchange portion having a high-pressure heat exchange channel, a first micro-fin array being provided inside the high-pressure heat exchange channel, and the second heat exchange portion having a low-pressure heat exchange channel, the high-pressure heat exchange channel and the low-pressure heat exchange channel being in communication through at least one nozzle disposed in the nozzle portion. The heat exchanger structure has a good heat exchange effect and can achieve a better heat flux during heat exchange. 1. A microchannel heat exchanger structure with a nozzle , comprising: a first heat exchange portion , a second heat exchange portion , and at least one nozzle portion between the first heat exchange portion and the second heat exchange portion , the first heat exchange portion having a high-pressure heat exchange channel , a first micro-fin array being provided inside the high-pressure heat exchange channel , and the second heat exchange portion having a low-pressure heat exchange channel , the high-pressure heat exchange channel and the low-pressure heat exchange channel being in communication through at least one nozzle disposed in the nozzle portion , the nozzle being a Laval nozzle or a conical nozzle.2. The microchannel heat exchanger structure with a nozzle according to claim 1 , wherein a first groove is provided on an end surface of the first heat exchange portion located on one side at which the nozzle portion is located claim 1 , and a medium inlet is provided on the other end surface claim 1 , the medium inlet being in communication with the first groove.3. The microchannel heat exchanger structure with a nozzle ...

Recombinant Polymerases for Improved Single Molecule Sequencing

Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties can include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template. 143-. (canceled)44. A composition comprising a recombinant DNA polymerase , which recombinant polymerase comprises an amino acid sequence that is at least 80% identical to SEQ ID NO:1 or SEQ ID NO:2 , which recombinant polymerase comprises one or more mutation selected from the group consisting of an amino acid substitution at position V19 , an amino acid substitution at position C22 , an amino acid substitution at position L142 , an amino acid substitution at position Y224 , an amino acid substitution at position E239 , an amino acid substitution at position N409 , an E508R substitution , an E508K substitution , a D510K substitution , a D510R substitution , and an E515Q substitution , wherein identification of positions is relative to SEQ ID NO:1 , and which recombinant polymerase exhibits polymerase activity.45. The composition of claim 44 , wherein the recombinant polymerase comprises one or more mutation selected from the group consisting of a V19C substitution claim 44 , a C22V substitution claim 44 , an L142K substitution claim 44 , a Y224K substitution claim 44 , an E239G substitution claim 44 , and an N409C substitution claim 44 , wherein identification of positions is relative to SEQ ID NO:1.46 ...

Method and apparatus for predicting mouth-shape feature, and electronic device

A method and apparatus for predicting a mouth-shape feature, and an electronic device are provided. A specific implementation of the method comprises: recognizing a phonetic posterior gram (PPG) of a phonetic feature; and performing a prediction on the PPG by using a neural network model, to predict a mouth-shape feature of the phonetic feature, the neural network model being obtained by training with training samples and an input thereof including a PPG and an output thereof including a mouth-shape feature, and the training samples including a PPG training sample and a mouth-shape feature training sample.

METHODS, DEVICES AND COMPUTER-READABLE STORAGE MEDIA FOR REAL-TIME SPEECH RECOGNITION

Methods, apparatuses, devices and computer-readable storage media for real-time speech recognition are provided. The method includes: based on an input speech signal, obtaining truncating information for truncating a sequence of features of the speech signal; based on the truncating information, truncating the sequence of features into a plurality of subsequences; and for each subsequence in the plurality of subsequences, obtaining a real-time recognition result through attention mechanism. 1. A method for real-time speech recognition , comprising:based on an input speech signal, obtaining, by one or more computing devices, truncating information for truncating a sequence of features of the speech signal;based on the truncating information, truncating, by the one or more computing devices, the sequence of features into a plurality of subsequences; andfor each subsequence in the plurality of subsequences, obtaining, by the one or more computing devices, a real-time recognition result through attention mechanism.2. The method of claim 1 , wherein the obtaining the truncating information for truncating the sequence of features of the speech signal claim 1 , comprises:obtaining, by the one or more computing devices, spike information related to the speech signal by performing connectionist temporal classification (CTC) on the sequence of features; anddetermining, by the one or more computing devices, the truncating information based on the spike information.3. The method of claim 1 , wherein the obtaining the real-time recognition result through the attention mechanism claim 1 , comprises:performing, by the one or more computing devices, a first attention modeling of an attention model on a first one of the plurality of subsequences, the attention model for enabling to select a feature for weighting; andperforming, by the one or more computing devices, a second attention modeling of the attention model on a second one of the plurality of subsequences, the first ...

RECOMBINANT POLYMERASES FOR IMPROVED SINGLE MOLECULE SEQUENCING

Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties can include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template. 1. A composition comprising a recombinant DNA polymerase , which recombinant polymerase comprises an amino acid sequence that is at least 80% identical to SEQ ID NO:1 or SEQ ID NO:2 , which recombinant polymerase comprises one or more mutation selected from the group consisting of an amino acid substitution at position A83 , an amino acid substitution at position C106 , an amino acid substitution at position A134 , an amino acid substitution at position R261 , an amino acid substitution at position R306 , an amino acid substitution at position W436 , and an amino acid substitution at position D476 , wherein identification of positions is relative to SEQ ID NO:1 , and which recombinant polymerase exhibits polymerase activity.2. The composition of claim 1 , wherein the recombinant polymerase comprises one or more mutation selected from the group consisting of a C106S substitution claim 1 , an A134S substitution claim 1 , an R261K substitution claim 1 , a W436Y substitution claim 1 , and a D476H substitution claim 1 , wherein identification of positions is relative to SEQ ID NO:1.3. The composition of claim 1 , wherein the recombinant polymerase comprises an amino acid sequence that is at least 90% ...

Voice Response Method and Device, and Smart Device

A voice response method, apparatus and intelligent device are disclosed. The method includes: receiving voice information sent by a user; determining whether the voice information contains a wake-up word; and if so, outputting a response voice according to a preset response rule. Thus, if there is a wake-up word in voice information received by the intelligent device, the intelligent device outputs a response voice according to a preset response rule. That is, after the user sends a wake-up word, the intelligent device outputs a voice to respond to the wake-up word. Therefore, the user can directly determine that the device has been woken up and can have a better experience.

KIF18A INHIBITORS

Compounds of formula (I): 4. The compound of claim 1 , or the pharmaceutically-acceptable salt thereof claim 1 , wherein Ris H or methyl.5. The compound of any one of to claim 1 , or the pharmaceutically-acceptable salt thereof claim 1 , wherein each of R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and Ris H claim 1 , halo claim 1 , Calk claim 1 , or Chaloalk; and each of Rand Rpair combine with the carbon atom attached to each of them form a saturated 3- claim 1 , 4- claim 1 , or 5-membered monocyclic ring spiro to the Rring; wherein said ring contains 0 claim 1 , 1 claim 1 , 2 or 3 N atoms and 0 claim 1 , 1 claim 1 , or 2 atoms selected from O and S.6. The compound of claim 1 , or the pharmaceutically-acceptable salt thereof claim 1 , wherein each of R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and Ris H claim 1 , methyl claim 1 , or ethyl; and each of Rand Rpair combine with the carbon atom attached to each of them form a cyclopropyl claim 1 , cyclobutyl claim 1 , or cyclopentyl ring spiro to the IV ring.10. The compound of claim 1 , or the pharmaceutically-acceptable salt thereof claim 1 , wherein Ris —CN claim 1 , or a group —Z—R claim 1 , wherein Z is a bond claim 1 , —NH— claim 1 , —NHSO— claim 1 , —SONH— claim 1 , —S(═O)(═NH)— claim 1 , —S— claim 1 , —S(═O)— claim 1 , —SO— claim 1 , —(C═O)— claim 1 , —(C═O)NH— claim 1 , or —NH(C═O)—; and{'sup': '12', '(a) Ris H;'}{'sup': '12', '(b) Ris oxetanyl, cyclopropyl; or'}{'sup': '12', 'sub': '1-6', '(c) Ris Calk substituted by 0, 1, 2 or 3 OH group(s).'}12. The compound of claim 1 , or the pharmaceutically-acceptable salt thereof claim 1 , wherein Ris a group —Z—R claim 1 , wherein Z is —NHSO— or —SONH—; and Ris oxetanyl claim 1 , cyclopropyl claim 1 , or Ris Calk substituted by 0 claim 1 , 1 claim 1 , 2 or 3 OH group(s).13. The compound of claim 1 , or the pharmaceutically-acceptable salt thereof claim 1 , wherein Ris a group —Z—R claim 1 , ...

sGC STIMULATORS

The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable. The compounds are of Formula I: 3. A compound according to claim 2 , or a pharmaceutically acceptable salt thereof claim 2 , wherein n is an integer selected from 1 or 2 and each Jis independently selected from halogen claim 2 , a Calkyl claim 2 , —ORor —OR.4. A compound according to claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , wherein n is 1.515-. (canceled)16. A compound according to claim 2 , or a pharmaceutically acceptable salt thereof claim 2 , wherein ring B is phenyl.17. A compound according to claim 16 , or a pharmaceutically acceptable salt thereof claim 16 , wherein n is 1 or 2.18. A compound according to claim 17 , or a pharmaceutically acceptable salt thereof claim 17 , wherein a Jis ortho to the attachment of the methylene linker between ring B and the core of the molecule claim 17 , and the Jis halogen.1923-. (canceled)2528-. (canceled)30. A compound according to claim 29 , or a pharmaceutically acceptable salt thereof claim 29 , wherein Ris H claim 29 , NRR claim 29 , —C(O)NRR claim 29 , C(O)R claim 29 , —SOR claim 29 , —SR claim 29 , halo claim 29 , —OCF claim 29 , —CN claim 29 , hydroxyl claim 29 , Calkenyl optionally and independently substituted with 0-2 occurrences of R claim 29 , Calkynyl optionally and independently substituted with 0-2 occurrences of R; Calkyl optionally and independently substituted with 0-5 occurrences of R claim 29 , Calkoxy optionally and independently substituted with 0-3 occurrences of R claim 29 , phenyl optionally and independently substituted with 0-3 occurrences ...

RECOMBINANT POLYMERASES FOR IMPROVED SINGLE MOLECULE SEQUENCING

Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties can include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template. 1. A composition comprising a recombinant DNA polymerase , which recombinant polymerase comprises an amino acid sequence that is at least 80% identical to SEQ ID NO:1 or SEQ ID NO:2 , which recombinant polymerase comprises one or more mutation selected from the group consisting of an amino acid substitution at position A68 , an amino acid substitution at position A83 , an amino acid substitution at position C106 , an amino acid substitution at position A134 , an amino acid substitution at position R261 , an amino acid substitution at position R306 , an amino acid substitution at position W436 , an amino acid substitution at position D476 , and an amino acid substitution at position P558 , wherein identification of positions is relative to SEQ ID NO: 1 , and which recombinant polymerase exhibits polymerase activity.2. The composition of claim 1 , wherein the recombinant polymerase comprises one or more mutation selected from the group consisting of an A68S substitution claim 1 , a C106S substitution claim 1 , an A134S substitution claim 1 , an R261K substitution claim 1 , a W436Y substitution claim 1 , a D476H substitution claim 1 , and a P558A substitution claim 1 , wherein identification of positions ...

STEAM GENERATION SYSTEM

The instant disclosure relates to steam generation systems. The disclosed steam generation systems, in some aspects, may relate to a forced circulation boiler that may be used in association with low energy water treatment systems. In certain aspects, the disclosed steam generation systems may allow for more environmentally-responsible steam generation. 1. A system for generating steam comprising:a low energy water treatment; anda forced circulation steam generator.2. A method of generating steam comprising the steps of:treating water using a low energy water treatment; anddirecting the water to a forced circulation steam generator.3. A method of treating feedwater for a forced circulation boiler comprising the steps of:subjecting the feedwater to at least one of WLS treatment and HLS treatment; andsubjecting the feedwater to at least one of WAC treatment, SAC treatment, and a combination of WAC and SAC treatments. This application claims benefit of and priority to U.S. Provisional Patent Application Ser. No. 61/971,605, filed Mar. 28, 2014, entitled “Steam Generation System,” the contents of which are incorporated herein for all purposes.This invention is in the field of steam generation, and more specifically to such systems that use forced circulation boilers.The generation of steam is frequently required for various applications, including for power generation, mining, and hydrocarbon production such as in Steam-Assisted Gravity Drainage (SAGD) and Cyclic Steam Stimulation (CSS) processes.Two common options for generating steam are through the use of steam generators in once-through steam generation (OTSG) and conventional drum boilers. In either case, treatment of the feedwater into the generator or boiler can be required to remove contaminants and protect the steam-generating equipment. The method and extent of this treatment can depend on the quality of water going into the system, and more importantly, the level of water quality required by the steam ...

Method and device for implementing voice input

A network device for implementing voice input comprises an input-obtaining module for obtaining voice input information, a sequence-determining module for determining an input character sequence corresponding to the voice input information based on a voice recognition model, an accuracy-determining module for determining appearance-probability information corresponding to word segments in the input character sequence so as to obtain accuracy information of the word segments, and a transmitting module for transmitting, to a user device, the input character sequence and the accuracy information of the word segments corresponding to the voice input information.

SYSTEM AND METHOD OF MEDICAL IMAGING

A system of medical imaging including a marking module, a classifying module, a region-of-interest determining module, a curve acquiring module and a delay calculating module. The marking module is used for marking one or more feature regions from pre-scanned images; the classifying module is used for classifying the feature regions by using a classification algorithm model; the region-of-interest determining module is used for selecting a feature region of the same type as a specific diagnostic tissue as a region of interest; the curve acquiring module is used for acquiring a curve of CT values of the region of interest in function of time, based on a relationship between the CT values and scanning time points; the delay calculating module is used for detecting a peak value of the curve and calculating a scan delay time based on a time point corresponding to the peak value. 1. A system of medical imaging , comprising:a marking module for marking one or more feature regions from a plurality of pre-scanned images;a classifying module for classifying the feature regions by using a classification algorithm model;a region-of-interest determining module for selecting a feature region of the same type as a specific diagnostic tissue as a region of interest;a curve acquiring module for acquiring a curve of CT values of the region of interest in function of time, based on a relationship between the CT values of the region of interest in the pre-scanned images and scanning time points of the corresponding images; anda delay calculating module for detecting a peak value of the curve and calculating a scan delay time based on a time point corresponding to the peak value.2. The system of medical imaging according to claim 1 , wherein the classification algorithm model comprises a K-means classification model or a VSM claim 1 , and the classifying module uses feature parameters of the marked feature regions as input values of the K-means classification model or the VSM to ...

Recombinant polymerases for improved single molecule sequencing

Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties can include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template.

sGC STIMULATORS

Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed. 1169-. (canceled)172. A pharmaceutical composition comprising a compound of claim 171 , or a pharmaceutically acceptable salt thereof claim 171 , and one or more excipients.174. A method of treating a disease claim 171 , health condition or disorder in a subject in need of treatment claim 171 , comprising administering a therapeutically effective amount of the compound of claim 171 , or a pharmaceutically acceptable salt thereof claim 171 , to the subject in need of treatment claim 171 , wherein the disease claim 171 , health condition or disorder is selected from: disorders related to high blood pressure and decreased coronary blood flow; increased acute and chronic coronary blood pressure; arterial hypertension; vascular disorder resulting from cardiac and renal complications, heart disease, stroke, cerebral ischemia or renal failure; resistant hypertension; diabetic hypertension; congestive heart failure; diastolic or systolic dysfunction; coronary insufficiency; arrhythmias; reduction of ventricular preload; cardiac hypertrophy; heart failure/cardiorenal syndrome; portal hypertension; endothelial dysfunction or injury;', "thromboembolic disorders and ischemias; myocardial infarction; stroke; transient ischemic attacks (TIAs); obstructive thromboanginitis; stable or unstable angina pectoris; coronary spasms; variant angina; Prinzmetal's angina; restenosis resulting from thrombolysis therapies; thrombogenic disorders;", "Alzheimer's disease; Parkinson's disease; dementia; vascular cognitive impairment; cerebral vasospasm; traumatic brain injury;", "peripheral arterial disease; peripheral occlusive arterial disease; peripheral vascular disease; hypertonias; Raynaud's syndrome or phenomenon; critical limb ischemia ...

RECOMBINANT POLYMERASES WITH INCREASED PHOTOTOLERANCE

Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties include increased resistance to photodamage, and can also include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template. 1. A composition comprising a Φ29-type (phi29-type) recombinant DNA polymerase , which recombinant polymerase comprises an amino acid sequence that is at least 80% identical to SEQ ID NO:2 , and which recombinant polymerase comprises one or more mutation selected from the group consisting of an amino acid substitution at position K128 , a K132Q substitution , a K132S substitution , an H146D substitution , a Q180F substitution , a G194D substitution , a G194E substitution , an I198E substitution , a K203E substitution , and an A434N substitution , wherein identification of positions is relative to SEQ ID NO:2 , and wherein said polymerase exhibits polymerase activity.2. The composition of claim 1 , wherein the recombinant polymerase comprises a K128E substitution or a K128Q substitution claim 1 , wherein identification of positions is relative to SEQ ID NO:2.3. The composition of claim 1 , wherein the recombinant polymerase comprises one or more mutation or combination of mutations selected from the group consisting of an amino acid substitution at position 250 claim 1 , an amino acid substitution at position 372 claim 1 , an amino acid substitution ...

METHOD, DEVICE, AND COMPUTER-READABLE STORAGE MEDIUM FOR SPEECH SYNTHESIS IN PARALLEL

The disclosure provides a method, an apparatus, a device, and a computer-readable storage medium for speech synthesis in parallel. The method includes: splitting a piece of text into a plurality of segments; based on the piece of text, obtaining a plurality of initial hidden states of the plurality of segments for a recurrent neural network. The method further includes: synthesizing the plurality of segments in parallel based on the plurality of initial hidden states and input features of the plurality of segments. 1. A method for speech synthesis in parallel , comprising:splitting a piece of text into a plurality of segments;based on the piece of text, obtaining a plurality of initial hidden states of the plurality of segments for a recurrent neural network; andsynthesizing the plurality of segments in parallel based on the plurality of initial hidden states and input features of the plurality of segments.2. The method of claim 1 , wherein each segment in the plurality of segments comprises any of a phoneme claim 1 , a syllable and a prosodic word claim 1 , and synthesizing the plurality of segments in parallel comprises:synthesizing each segment serially in an autoregressive manner based on the initial hidden state and the input feature of each segment.3. The method of claim 1 , wherein obtaining the plurality of initial hidden states of the plurality of segments for the recurrent neural network comprises:determining a phoneme-level input feature of each segment in the plurality of segments; andbased on the phoneme-level input feature of each segment, predicting the initial hidden state of each segment by using a hidden state prediction model subjected to training.4. The method of claim 3 , wherein synthesizing the plurality of segments in parallel comprises:determining a frame-level input feature of each segment in the plurality of segments;based on the frame-level input feature, obtaining a sample-point level feature by utilizing an acoustic condition model; ...

Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors

Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

Kif18a inhibitors

Compounds of formula (I): (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

Kif18a inhibitors

Compounds of formula (I): (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

Heteroaryl amides useful as kif18a inhibitors

The present invention relates to chemical compounds having a general formula (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

Heteroaryl amides useful as kif18a inhibitors

The present invention relates to chemical compounds having a general formula (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors

Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

HETEROARYL AMIDES USEFUL AS KIF18A INHIBITORS

KIF18A inhibitors

Compounds of formula (I): (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

Intercalated single-chain variable fragments

Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors

Enantiomerically pure compound of formula (I) are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors

Compounds of formula (1) are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

Sequencing methods using enzyme conformation

Systems and methods are provided for single-molecule sequencing of template nucleic acids in which the signal from a label attached to a polymerase enzyme is used to monitor conformational changes in the polymerase which occur while labeled nucleotides or nucleotide analogs are added to a growing nucleic acid chain which is complementary to the template nucleic acid. The signal indicative of the conformational state of the enzyme is used to determine with higher confidence when true nucleotide or nucleotide analog incorporation events occur, allowing for the improved quality of base calls and sequence determination.

Pyrazole-substituted amino heteroaryl compounds as protein kinase inhibitors.

Forbindelser med formel (1) er tilveiebragt, så vel som fremgangsmåter for deres syntese og anvendelse. Foretrukne forbindelser er pontente inhibitorer av c-Metproteinkinase og er anvendelige ved behandling av abnormal cellevekstforstyrrelser, slik som kreft.

Triazolopyrazine derivatives useful as anti-cancer agents.

La invención se refiere a compuestos de fórmula I (ver fórmula (I)) o una sal farmacéuticamente aceptable de los mismos, en la que R1, R2, R3 y R4 son como se definen en esta invención. La invención también se refiere a composiciones farmacéuticas que contienen los compuestos de fórmula I y a procedimientos de tratamiento de trastornos hiperproliferativos en un mamífero mediante administración de los compuestos de fórmula I.

HETEROARYL AMIDES USEFUL AS KIF18A INHIBITORS

Training method and apparatus for a speech synthesis model, and storage medium

The present application discloses a training method and an apparatus for a speech synthesis model, electronic device, and storage medium. The method includes: taking a syllable input sequence, a phoneme input sequence and a Chinese character input sequence of a current sample as inputs of an encoder of a model to be trained, to obtain encoded representations of these three sequences at an output end of the encoder; fusing the encoded representations of these three sequences, to obtain a weighted combination of these three sequences; taking the weighted combination as an input of an attention module, to obtain a weighted average of the weighted combination at each moment at an output end of the attention module; taking the weighted average as an input of a decoder of the model to be trained, to obtain a speech Mel spectrum of the current sample at an output end of the decoder.

Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors

Enantiomerically pure compound of formula (I) are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

Aminoheteroaryl compounds as protein kinase inhibitors

Opisani su aminopiridinski i aminopirazinski spojevi formule (1), pripravci koji uključuju ove spojeve, postupci za njihovu upotrebu i postupci za njihovu upotrebu. Poželjni spojevi formule 1 imaju aktivnost inhibitora proteinskih kinaza, uključuju inhibitore c-MET.

Low operation-voltage constant-current circuit

Human-computer interaction method, device, electronic apparatus, storage media and computer program

【課題】音声インタラクションの効率を向上させ、ユーザのインタラクティブ体験を向上させるヒューマンコンピュータインタラクション方法、装置、電子機器、記憶媒体およびコンピュータプログラムを提供する。【解決手段】ヒューマンコンピュータインタラクション方法は、音声コマンドを取得するステップと、音声コマンドに対して音声認識を行い、対応する音声テキストを確定するステップと、予め設定された情報送信条件を満たすことに応答して、音声テキストをクラウドに送信するステップと、クラウドから返された、音声コマンドに対応するリソースを受信するステップと、リソースに基づいて、音声コマンドに応答するステップと、を含む。【選択図】図２

Bolt locking method, bolt unlocking method, bolt locking and unlocking method, and automotive battery replacing method

Disclosed are a bolt locking method, a bolt unlocking method, a bolt locking/unlocking control method, and a vehicle battery replacement method. The bolt locking method is used for a bolt locking device, which comprises a bolt screwing element and a locking-assisting check block used for providing a reaction force to adjust a screwing torque of the bolt screwing element; and the bolt locking method comprises: a docking step S110, wherein the bolt screwing element is driven to be centered and engaged with a bolt end at a first speed in a first set interval of numbers of screwing turns for docking, and at this moment the bolt screwing element abuts against the locking-assisting check block; and a locking step S120, wherein the bolt screwing element is driven to screw a bolt at a second speed in a set interval of numbers of screwing turns for locking until a screwing torque is increased to a set locking torque, and at this moment it is determined that the bolt is successfully locked; and meanwhile, the bolt screwing element counteracts the reaction force of the locking-assisting check block. With the bolt locking/unlocking method, effective protection of the bolt locking/unlocking process and flexible control of bolt locking/unlocking are achieved.

Triazolopyrazine derivatives useful as anti-cancer agents

Disclosed are triazolopyrazine derivatives of formula I wherein the substituents are disclosed within the specification or a pharmaceutically acceptable salt thereof. Also disclosed is the use of a pharmaceutical composition comprising a compound of formula I for treatment of c-Met related disorders in mammals.

ENANTIOMETRICALLY PURE AMINOHETEROARILO COMPOUNDS AS PROTEIN QUINASE INHIBITORS

Se proporciona un compuesto enantiomericamente puro de formula 1 asi como procedimeintos para su sintesis y uso. Los compuestos preferidos son potentes inhibidores de la proteina quinasa c-Met, y son utiles en el tratamiento de trastornos del crecimiento celular anormal, tales como canceres.

PROCESS FOR PLANTING PEANUTS ON A SALINE SOIL WITH ALKALIS AND SPECIAL FERTILIZER APPLIED IN THIS PROCEDURE

La présente invention concerne un procédé de plantation d’une culture sur une terre saline à alcalis comprenant les étapes suivantes : réaliser une culture après fertilisation, avec une largeur de 70 à 110 cm ; former un petit sillon d’une largeur et une profondeur de 8 à 12 cm au milieu d’une zone de semis ; former des exhaussements d’une hauteur de 10 à 20 cm et d’une largeur inférieure de 15 à 25 cm sur les bords latéraux ; prévoir un écartement entre rangs de 35 à 55 cm ; pailler sur toute la largeur à des fins de plantation, mais laisser 3 à 10 cm non paillés sur deux bords latéraux de la largeur ; creuser des trous dans une couche de fond dans le petit sillon à intervalles de 3 à 8 cm, et ensuite recouvrir les trous avec de la terre. The present invention relates to a method of planting a crop on saline alkali soil comprising the following steps: producing a crop after fertilization, with a width of 70 to 110 cm; form a small furrow 8 to 12 cm wide and deep in the middle of a seedling area; form raises with a height of 10 to 20 cm and a lower width of 15 to 25 cm on the side edges; provide a spacing between rows of 35 to 55 cm; mulch the full width for planting, but leave 3-10 cm unmulched on two side edges of the width; dig holes in a base layer in the small furrow at 3-8 cm intervals, and then cover the holes with soil.

Aminoheteroaryl compounds as protein kinase inhibitors

Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET.

Waste lead-acid battery electrolyte treatment device

本实用新型公开了一种废旧铅酸电池电解液处理装置，包括过滤池、沉淀收集池和浓缩池，过滤池内依次间隔设置若干个锥形过滤箱，相邻两个锥形过滤箱之间通过第一导液管连通，各锥形过滤箱内分别嵌装有倾斜的过滤网，各锥形过滤箱底部设置有与沉淀收集池顶部连通的出料管，抽吸泵的吸入端通过第二导管与相近的锥形过滤箱的导出室连通，抽吸泵的输出端通过第三导管与浓缩室顶部连通，浓缩池底部外侧设置有与锥形底的底部连通的出液口，浓缩池外侧于出液口上方设置有与浓缩室连通的收集口；本实用新型通过设置多个锥形过滤箱，利用网孔依次减小的过滤网对电解液进行多级过滤，然后再经浓缩池进行浓缩处理，预处理效果好。

Method for human-computer interaction, apparatus for human-computer interaction, device, and storage medium

The present disclosure provides a method for a human-computer interaction, an apparatus for a human-computer interaction, a device, and a storage medium, and the present disclosure relates to the field of artificial intelligence, such as deep learning and voice. A specific implementation includes: acquiring a voice command; performing voice recognition on the voice command to determine a corresponding voice text; sending, in response to satisfying a preset information sending condition, the voice text to a cloud; receiving a resource for the voice command returned from the cloud; and responding to the voice command based on the resource.

Method for producing silencing device, silencing device and air purifier

A silencing device, an air purifier, and a method for producing the same are provided. The method includes that: a sound wave spectrum when an air purifier to be silenced performs operations is acquired; a frequency value, which exceeds a sound wave frequency limit for the air purifier, of the sound wave spectrum is calculated; and a silencing device adapted to the air purifier to be silenced is produced according to the frequency value. At least one structural parameter of the silencing device is configured according to the frequency value. The silencing device is configured to reduce a sound with the frequency value exceeding the sound wave frequency limit.