13-09-2012 дата публикации
Номер: US20120232068A1
A compound of formula (I) wherein A, X, Y, Z, Rand Rare described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, Iassociated disorders, and other disorders mediated by ion channel function. 7. The compound claim 6 , enantiomer claim 6 , diastereomer claim 6 , tautomer claim 6 , or salt thereof claim 6 , of claim 6 , wherein:{'sub': 1-10', '1-10', '2', '1', '11', '12, 'X is H, F, Cl, Br, I, Calkoxy, haloCalkyl, —CORor —NRR;'}{'sub': 1-10', '1-10', '2', '11', '11', '12, 'Y is H, F, Cl, Br, I, Calkoxy, haloCalkyl, —CORor —NRR;'}{'sub': 1-10', '1-10', '11', '12, 'Z is H, Cl, Br, I, Calkoxy, haloCalkyl or —NRR;'}{'sub': 11', '12', '1-10', '1-10', '3-10', '6-10', '13, "Rand R, at each occurrence, are independently selected from H, Calkyl, haloCalkyl, Ccycloalkyl, Caryl, a 4- to 12-membered heteroaryl and a 4- to 12-membered heterocyclyl, wherein the alkyl, cycloalkyl, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, or 4 heteroatoms independently selected from the group consisting of N, S, or O;"}{'sub': 13a', '1-10', '2-10', '1-10', '3-10', '2-12', '6-10', '1-10', '2', 'm', '2', '14', '14', '2', '14', '14', '14', '2', 'm', '14', '2', '14', '2', 'm', '14', '2', '14', '14', '14', '2', '14', '14', '2', '14', '14', '14', '2', '14', '14', '14', '14', '2', '14', '14', '14', '14a, "Ris independently H, —OH, F, Cl, Br, I, Calkyl, Calkoxy, haloCalkyl, Ccycloalkyl, Calkenyl, Caryl, a 4- to 12-membered heteroaryl, a 4- to 12-membered heterocyclyl, a 4- to 12-membered heteroaryl-Calkyl, —CN, —(CH)—SOR, —NRSOR, —CONRR, —(CH)—NRSOR, —(CH)—NRSONRR, —NRSONRR, —CONRR, —NRCONRR, —NRCOR, —CORor —NRR, wherein the alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl and heterocyclyl may be optionally substituted with one or more R's and the heteroaryl and heterocyclyl consist of carbon atoms and 1, 2, 3, ...
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