Unterrichtspult

AUTOMATIC ENERGY MANAGEMENT AND ENERGY CONSUMPTION REDUCTION, ESPECIALLY IN COMMERCIAL AND MULTI- BUILDING SYSTEMS

Automatic energy management and energy consumption reduction, especially in commercial and multi- building systems

Antibody L5H5 with CD20-resistant antigen and application thereof

The invention discloses an antibody L5H5 with a CD20-resistant antigen and application thereof. The antibody L5H5 with the CD20-resistant antigen is IgG (intravenous gamma globulin), wherein a light chain of the IgG is composed of a light chain variable region and a light chain constant region, and a heavy chain of the IgG is composed of a heavy chain variable region, a hinge region and a heavy chain constant region; CDR1, CDR2 and CDR3 in the light chain variable region are sequentially 61st-74th amino acid residues, 89th-102nd amino acid residues and 112nd-123rd amino acid residues from the N tail end of a sequence 1 in a sequence table; CDR1, CDR2 and CDR3 in the heavy chain variable region are sequentially 49th-59th amino acid residues, 81st-96th amino acid residues and 106th-119th amino acid residues from the N tail end of a sequence 3 in the sequence table. The invention also discloses the application of the antibody L5H5 to preparation of a drug for treating B-cell lymphoma. The ...

Antibody L5H7 of anit-CD20 antigen and application of antibody L5H7

The invention discloses an antibody L5H7 of anti-CD20 antigen and application of the antibody L5H7. The anti-CD20 antigen provided by the invention is named the L5H7 antibody, and is IgG, wherein a light chain of the IgG is composed of a light chain variable region and a light chain constant region; a heavy chain of the IgG consists of a heavy chain variable region, a hinge region and a heavy chain constant region; CDR1, CDR2 and CDR3 in the light chain variable region are the 61st-74-th-lotus amino acid residue, the 89th-102nd-lotus amino acid residue and 112nd-123rd-lotus amino acid residue from the N tail end of a sequence 1 of a sequence table; the CDR1, CDR2 and CDR3 in the heavy chain variable region are the 50th-67th-lotus amino acid residue, 81st-96th-lotus amino acid residue and 102nd-119th-lotus amino acid residue from the N tail end of the sequence 3 of the sequence table. The invention further protects application of the antibody L5H7 in preparation of a drug for treating B ...

Antibody L4H7 with CD20-resistant antigen and application thereof

The invention discloses an antibody L4H7 with a CD20-resistant antigen and application thereof. The antibody L4H7 with the CD20-resistant antigen is an IgG (intravenous gamma globulin), wherein a light chain of the IgG is composed of a light chain variable region and a light chain constant region, and a heavy chain of the IgG is composed of a heavy chain variable region, a hinge region and a heavy chain constant region; CDR1, CDR2 and CDR3 in the light chain variable region are sequentially 61rt-79th amino acid residues, 89th-102nd amino acid residues and 112nd-123rd amino acid residues from the N tail end of a sequence 1 in a sequence table; CDR1, CDR2 and CDR3 in the heavy chain variable region are sequentially 50th-67th amino acid residues, 81rt-96th amino acid residues and 102nd-119th amino acid residues from the N tail end of a sequence 3 in the sequence table. The invention also discloses the application of the antibody L4H7 to preparation of a drug for treating B-cell lymphoma. The ...

Run-Length Encoding Decompression

Approaches are described to improve database performance by implementing a RLE decompression function at a low level within a general-purpose processor or an external block. Specifically, embodiments of a hardware implementation of an instruction for RLE decompression are disclosed. The described approaches improve performance by supporting the RLE decompression function within a processor and/or external block. Specifically, a RLE decompression hardware implementation is disclosed that produces a 64-bit RLE decompression result, with an example embodiment performing the task in two pipelined execution stages with a throughput of one per cycle. According to embodiments, hardware organization of narrow-width shifters operating in parallel, controlled by computed shift counts, is used to perform the decompression. Because of the decreased time required to perform RLE decompression according to embodiments, the performance of tasks that use embodiments described herein for decompression of run-length encoded data is made more efficient.

Antibody L5H6 with CD20-resistant antigen and application thereof

The invention discloses an antibody L5H6 with a CD20-resistant antigen and application thereof. The antibody L5H6 with the CD20-resistant antigen is an IgG (intravenous gamma globulin), wherein a light chain of the IgG is composed of a light chain variable region and a light chain constant region, and a heavy chain of the IgG is composed of a heavy chain variable region, a hinge region and a heavy chain constant region; CDR1, CDR2 and CDR3 in the light chain variable region are sequentially 61st-74th amino acid residues, 89th-102nd amino acid residues and 112nd-123rd amino acid residues from the N tail end of a sequence 1 in a sequence table; CDR1, CDR2 and CDR3 in the heavy chain variable region are sequentially 57th-67th amino acid residues, 81st-96th amino acid residues and 106th-119th amino acid residues from the N tail end of a sequence 3 in the sequence table. The invention also discloses the application of the antibody L5H6 to preparation of a drug for treating B-cell lymphoma. The ...

Antigen CD20 resisting antibody L1H1 and application thereof

The invention discloses an antigen CD20 resisting antibody L1H1 and application thereof. The antigen CD20 resisting antibody disclosed by the invention is named antibody L1H1 and is IgG (Immunoglobulin G), a light chain of the IgG consists of a light-chain variable region and a light-chain constant region, and a heavy chain of the IgG consists of a heavy-chain variable region, a hinge region and a heavy-chain constant region; CDR1, CDR2 and CDR3 in the light-chain variable region are 37th to 48th amino acid residues, 61st to 79th amino acid residues and 89th to 104th amino acid residues sequentially from the N tail end of a sequence 1 of a sequence table; CDR1, CDR2 and CDR3 in the heavy-chain variable region are 58th to 68th amino acid residues, 85th to 111th amino acid residues and 130th to 136th amino acid residues sequentially from the N tail end of a sequence 3 of the sequence table. The invention further discloses application of the antibody L1H1 in preparation of drugs for treating ...

Antibody L4H5 with CD20-resistant antigen and application thereof

The invention discloses an antibody L4H5 with a CD20-resistant antigen and application thereof. The antibody L4H5 with the CD20-resistant antigen is an IgG (intravenous gamma globulin), wherein a light chain of the IgG is composed of a light chain variable region and a light chain constant region, and a heavy chain of the IgG is composed of a heavy chain variable region, a hinge region and a heavy chain constant region; CDR1, CDR2 and CDR3 in the light chain variable region are sequentially 61st-79th amino acid residues, 89th-102nd amino acid residues and 112nd-123rd amino acid residues from the N tail end of a sequence 1 in a sequence table; CDR1, CDR2 and CDR3 in the heavy chain variable region are sequentially 49th-59th amino acid residues, 81rt-96th amino acid residues and 106th-119th amino acid residues from the N tail end of a sequence 3 in the sequence table. The invention also discloses the application of the antibody L4H5 to preparation of a drug for treating B-cell lymphoma. The ...

Automatic energy management and energy consumption reduction, especially in commercial and multi-building systems

Bicyclic mglur5 positive allosteric modulators and methods of making and using same

In one aspect, the invention relates to bicyclic mGluR5 positive allosteric modulators, for example 6-(phenylethynyl)-3,4-dihydroisoquinolin-1(2H)-one, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME

In one aspect, the invention relates to bicyclic mGluR5 positive allosteric modulators, for example 6-(phenylethynyl)-3,4-dihydroisoquinolin-1(2H)-one, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. 2. The compound of claim 1 ,{'sup': '1', 'sub': 2', 'm', '2', 'm, 'wherein Ris an organic radical comprising 1 to 12 carbon atoms selected from optionally substituted C1-C6 alkyl or C2-C6 alkenyl or C2-C6 alkynyl, optionally substituted C1-C6 heteroalkyl or C2-C6 heteroalkenyl or C2-C6 heteroalkynyl, optionally substituted C3-C8 cycloalkyl or C3-C8 cycloalkenyl or C6-C8 cycloalkynyl, optionally substituted C3-C8 heterocycloalkyl or C3-C8 heterocycloalkenyl or C6-C8 heterocycloalkynyl, optionally substituted aryl, optionally substituted heteroaryl, and —(CH)-aryl or —(CH)-heterocycle, wherein m is 1, 2, 3 or 4; and'}{'sup': '5', 'wherein Ris an organic radical comprising 4 to 14 carbon atoms selected from optionally substituted C3-C8 cycloalkyl or C3-C8 cycloalkenyl, optionally substituted C3-C6 heterocycloalkyl or C3-C6 heterocycloalkenyl, optionally substituted aryl, and optionally substituted heteroaryl.'}15. The method of claim 11 , wherein the mammal is human.16. The method of claim 11 , wherein the mammal has been diagnosed with a need for potentiation of metabotropic glutamate receptor activity prior to the administering step.21. The method of claim 17 , wherein the mammal is human.22. The method of claim 17 , wherein the disorder is a neurological and/or psychiatric disorder ...

PIN DISPENSING SYSTEM AND METHOD

A pin dispensing apparatus including a dispenser configured to present a pin to a user, a transfer member configured to convey the pin to the dispenser, and a delivery mechanism configured to provide the pin to the transfer member. 1. A pin dispensing apparatus comprising:a dispenser, the dispenser configured to present a pin to a user;a transfer member, the transfer member configured to convey the pin to the dispenser; anda delivery mechanism, the delivery mechanism configured to provide the pin to the transfer member.2. The apparatus of claim 1 , wherein the dispenser is configured to liftably engage a pin.3. The apparatus of claim 1 , wherein the transfer member sequentially orders at least one pin claim 1 , and the dispenser presents the at least one pin one at a time.4. The apparatus of claim 1 , wherein the dispenser further comprises:a presenting position;a loading position; anda return mechanism, the return mechanism configured to urge the dispenser towards the presenting position after the dispenser has been depressed from the presenting position towards the loading position.5. The apparatus of claim 4 , wherein the return mechanism comprises a biased spring.6. The apparatus of claim 1 , wherein the transfer member comprises:a first end, the first end disposed near the dispenser;a second end, the second end disposed opposite the first; anda chute, the chute disposed substantially between the first and second ends.7. The apparatus of claim 6 , wherein the chute is configured to receive a pin shank.8. The apparatus of claim 6 , wherein the transfer member is configured to convey a pin from the second end towards the first end at least partially by a gravity feed.9. The apparatus of claim 1 , wherein the delivery mechanism comprises a housing having:at least one sidewall;the at least one sidewall defining a cavity;the at least one sidewall having an end;the end of the at least one sidewall defining an aperture; andan axis of rotation, the axis of rotation ...

Mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and use thereof.

ARYL AND HETEROARYL SULFONES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION

In one aspect, the invention relates to sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. 2. The method of claim 1 , wherein the mammal is a human.3. The method of claim 1 , wherein the dysfunction is Parkinson's disease.4. The method of claim 1 , wherein the dysfunction is schizophrenia claim 1 , psychosis claim 1 , “schizophrenia-spectrum” disorder claim 1 , depression claim 1 , bipolar disorder claim 1 , cognitive disorder claim 1 , delirium claim 1 , amnestic disorder claim 1 , anxiety disorder claim 1 , attention disorder claim 1 , obesity claim 1 , eating disorder claim 1 , or NMDA receptor-related disorder.5. The method of claim 1 , wherein the dysfunction is Parkinson's disease; anxiety; motor effects after alcohol consumption; neurogenic fate commitment and neuronal survival; epilepsy; or certain cancers claim 1 , for example claim 1 , medulloblastoma claim 1 , inflammation (for example claim 1 , multiple sclerosis) and metabolic disorders (for example claim 1 , diabetes) and taste enhancing associated with glutamatergic dysfunction and diseases in which mGluR4 receptor is involved.6. The method of claim 1 , wherein the mammal has been diagnosed with the dysfunction prior to the administering step.7. The method of claim 1 , further comprising the step of identifying a mammal having a need for treatment of the dysfunction.9. The method of claim 8 , wherein the subject is a mammal.10. The method of claim 8 , wherein the subject is a human.11. The method of claim 8 , wherein the subject has been diagnosed with a need for potentiation of mGluR4 receptor activity prior to the administering step.12. The ...

CONTROLLING TIME-SENSITIVE CONTENT IN A TIME-SHIFTED ENVIRONMENT

A device for recording a scheduled program comprises a means adapted for receiving data from a multi-program transport stream system that is configured to transmit multiple audio or video programs over a channel in multiple streams, the multi-program transport stream system further providing program identifiers to the streams in the channel that identifies a first program identifier with a first stream having at least a portion of a scheduled program and indentifies a second program identifier with a second stream having the scheduled program in its entirety; and a storage means adapted for identifying the scheduled program by the second program identifier and recording the scheduled program in its entirety while the unscheduled interrupting program is provided in real time. 1. A system for recording a scheduled program comprising:a multi-program transport stream means that is adapted to transmit multiple audio or video programs over a channel in multiple streams;a means of providing program identifiers to the streams in the channel that identifies a first program identifier with a first stream having at least a portion of a scheduled program and indentifies a second program identifier with a second stream having the scheduled program in its entirety; anda storage means that identifies the scheduled program by the second program identifier and records the scheduled program in its entirety while the unscheduled interrupting program is provided in real time.2. The system of claim 1 , wherein:the scheduled program has a program start time and a program end time; andthe storage means records and stores a recording in which the recording has a recorded program start time and a recorded program end time corresponding the program start time and the program end time.3. The system of claim 2 , wherein the recorded program end time does not extend beyond the program end time.4. A method comprising the steps of:receiving a multi-program transport stream for a scheduled program ...

ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODIES AND USES THEREOF

The present invention discloses humanized anti-epidermal growth factor receptor antibodies, which have favorable binding activity (the binding affinity being 6.13×10mol/L) and are able to inhibit the growth and migration of tumor cells. The present invention also discloses the preparation methods and uses of the antibodies 1. An antibody , wherein the heavy chain variable region of the antibody has the amino acid sequence as set forth by SEQ ID NO. 3 , and the light chain of the antibody has the amino acid sequence as set forth by SEQ ID NO. 2.2. The antibody according to claim 1 , wherein the antibody comprises a heavy chain and the light chain claim 1 , and the heavy chain comprises the heavy chain variable region and a heavy chain constant region.3. The antibody according to claim 2 , wherein the heavy chain constant region comprises an amino acid sequence as set forth by SEQ ID NO. 11.4. An isolated DNA encoding the heavy chain variable region of claim 2 , or an isolated DNA encoding the light chain of .5. The isolated DNA according to claim 4 , wherein the isolated DNA encoding the heavy chain variable region comprises the following 1) claim 4 , 2) or 3):1) an isolated DNA molecule having the nucleotide sequence as set forth by SEQ ID NO. 6;2) an isolated DNA molecule, which hybridizes with the DNA sequence defined in 1) under stringent conditions, and which encodes the heavy chain variable region;3) an isolated DNA molecule encoding the heavy chain variable region, wherein an amino acid sequence encoding the heavy chain variable region contains sequence having more than 70% homology to amino acids at positions 51-70 starting from the N-terminal of SEQ ID NO. 3 (i.e., nucleotides at positions 153 bp-210 bp starting from the 5′ end of SEQ ID NO. 6;an isolated DNA encoding the light chain comprising the following I), II) or III):I) an isolated DNA molecule having the nucleotide sequence as set forth by SEQ ID NO. 5;II) an isolated DNA molecule, which hybridizes ...

METHOD FOR QUANTITATIVE MEASUREMENT OF GENE EXPRESSION FOR INDENTIFYING INDIVIDUALS AT RISK FOR BRONCHOGENIC CARCINOMA

A method measure expression of multiple target genes in a progenitor cell for bronchogenic carcinoma comprising the use of reverse transcription-polymerase chain reaction (RT-PCR) to allow simultaneous expression measurement of the multiple target genes is disclosed. 1. A method to measure expression of multiple target genes in a progenitor cell for bronchogenic carcinoma comprising: using reverse transcription-polymerase chain reaction (RT-PCR) to allow simultaneous expression measurement of the multiple target genes.2. The method of claim 1 , which quantitative competitive RT-PCR is used to measure mRNA levels of glutathione-S-transferases (GSTs) and glutathione peroxidases (GSHPxs) in the progenitor cell.3. The method of claim 2 , in which the progenitor cell comprises a bronchial epithelial cell.4. The method of claim 3 , in which at least one of the mRNA levels of the following glutathione-S-transferases are measured: mGST claim 3 , GSTM3 claim 3 , combined GSTM1 claim 3 , 2 claim 3 , 4 claim 3 , 5 claim 3 , GSTT1 claim 3 , GSTP1 claim 3 , GSHPx claim 3 , and GSHPxA.5. The method of claim 4 , in which the levels of GSTP1 claim 4 , GSTM3 and GSHPx are significantly lower in normal bronchial epithelial cell than in bronchogenic carcinoma cells.6. The method of claim 4 , in which a gene expression index is evaluated by multiplying the values for: mGSTXGSTM3XGSHPxXGSHPxAXGSTP1.7. The method of claim 4 , in which a gene expression index is evaluated by multiplying the values for: mGSTXGSTM3XGSHPxXGSTP1.8. The method of claim 4 , in which a gene expression index is evaluated by multiplying the values for: GSTP1XmGSTXGSHPx.9. The method of claim 4 , in which a gene expression index is evaluated by multiplying the values for: GSTP1XGSHPxXGSTM3.10. The method of claim 4 , in which a gene expression index is evaluated by multiplying the values for: mGSTXGSTM3XGSHPx.11. The method of claim 4 , in which a gene expression index is evaluated by multiplying the values for: ...

ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODIES AND USES THEREOF

The present invention discloses humanized anti-epidermal growth factor receptor antibodies, which have favorable binding activity (the binding affinity being 5.09×10mol/L) and are able to inhibit the growth and migration of tumor cells. The present invention also discloses the preparation methods and uses of the antibodies. 1. An antibody , wherein the heavy chain variable region of the antibody has the amino acid sequence as set forth by SEQ ID NO. 3 , and the light chain of the antibody has the amino acid sequence as set forth by SEQ ID NO. 2.2. The antibody according to claim 1 , wherein the antibody comprises a heavy chain and the light chain claim 1 , and the heavy chain comprises the heavy chain variable region and a heavy chain constant region.3. The antibody according to claim 2 , wherein the heavy chain constant region comprises an amino acid sequence as set forth by SEQ ID NO. 11.4. An isolated DNA encoding the heavy chain variable region of claim 2 , or an isolated DNA encoding the light chain of .5. The isolated DNA according to claim 4 , wherein the isolated DNA encoding the heavy chain variable region comprises the following 1) claim 4 , 2) or 3):1) an isolated DNA molecule having the nucleotide sequence as set forth by SEQ ID NO. 6;2) an isolated DNA molecule, which hybridizes with the DNA sequence defined in 1) under stringent conditions, and which encodes the heavy chain variable region;3) an isolated DNA molecule encoding the heavy chain variable region, wherein an amino acid sequence encoding the heavy chain variable region contains sequence having more than 70% homology to amino acids at positions 51-70 starting from the N-terminal of SEQ ID NO. 3 (i.e., nucleotides at positions 153 bp-210 bp starting from the 5′ end of SEQ ID NO. 6);an isolated DNA encoding the light chain comprising the following I), II) or III):I) an isolated DNA molecule having the nucleotide sequence as set forth by SEQ ID NO. 5;II) an isolated DNA molecule, which hybridizes ...

SEMI-AUTONOMOUS UNDERWATER VEHICLE

A semi-autonomous underwater vehicle has (a) a hull; (b) one or more thruster motors; (c) a preprogrammed controller for controlling the motors and/or separate steering components to carry out a plurality of different maneuvers; and (d) a wireless signal receiver for providing instructions to the controller. 1. A semi-autonomous underwater vehicle comprising:(a) a hull;(b) one or more thruster motors;(c) a preprogrammed controller for controlling the motors and the steering components to carry out a plurality of different pre-programmed maneuvers; and(d) a wireless signal receiver for providing instructions to the controller.2. The semi-autonomous underwater vehicle of wherein the thruster motors provide the vehicle with the ability to steer the vehicle left claim 1 , right claim 1 , up and down.3. The semi-autonomous underwater vehicle of wherein the vehicle further comprises one or more function providers chosen from the list of function providers consisting of lights claim 1 , transducers and vibrators.4. The semi-autonomous underwater vehicle of wherein the function providers are activated and deactivated pursuant to a preprogrammed schedule.5. The semi-autonomous underwater vehicle of wherein the wireless signal receiver is adapted to accept acoustic modem/pulse signals while the vehicle is underwater. This application claims priority from U.S. Provisional Application Ser. No. 61/595,808, filed on Feb. 7, 2012, entitled SEMI-AUTONOMOUS UNDERWATER VEHICLE, the entirety of which is incorporated herein by reference.The invention relates generally to devices useful in defusing emergency situations arising from the overly aggressive behavior of a cetacean (e.g. killer whale) or other large aquatic animal.Emergency situations arising from the overly aggressive behavior of a cetacean or other large aquatic animal occasionally arise. Such emergency situations most often arise with respect to killer whales performing or being trained in an aquatic amusement park.Overly ...

DNS FORWARDER FOR MULTI-CORE PLATFORMS

In a multi-core platform in which secondary processor cores do not have direct WAN connectivity, methods and apparatus are described that enable the secondary cores to provide DNS resolution services to their network applications or to attached client devices. In an exemplary embodiment, a primary processor core having direct WAN connectivity includes a DNS forwarder which shares with the platform's secondary processing cores DNS server IP address information acquired from a WAN-side DHCP server. Each secondary core implements a compatible DNS forwarder client to request DNS information from the primary core DNS forwarder, receive the information, and make it available to its operating system's DNS resolver module. Additionally, or alternatively, the primary core DNS forwarder may push updated DNS server information to each secondary core following a primary core DHCP client lease renewal. 1. A method of providing Domain Name System (DNS) resolution service in a multi-core platform comprising: providing the DNS server information to a secondary processing core of the multi-core platform;', 'generating a DNS query at the secondary processing core using the DNS server information; and', 'sending the DNS query to the DNS server via the primary processing core., 'receiving at a primary processing core of the multi-core platform, DNS server information relating to a DNS server;'}2. The method of comprising sending a request for the DNS server information from the secondary processing core to the primary processing core claim 1 , wherein the primary processing core provides the DNS server information to the secondary processing core in response to the request.3. The method of comprising storing the DNS server information at the primary processing core.4. The method of comprising installing the DNS server information in a DNS resolver of the secondary processing core.5. The method of claim 1 , wherein the DNS server information includes an Internet Protocol (IP) address of ...

DNS PROXY SERVICE FOR MULTI-CORE PLATFORMS

In a multi-core platform in which secondary processing cores do not have direct WAN connectivity, methods and apparatus are described that enable the secondary processing cores to provide DNS resolution services to their network applications and/or client devices attached thereto. In an exemplary embodiment, a primary processing core having direct WAN connectivity and a DHCP client includes a DNS proxy service module which acts as a DNS server to the platform's secondary processing cores. Each secondary processing core sends DNS queries to the primary core DNS proxy service module. A primary core DNS resolver regenerates DNS queries based on the DNS queries from the secondary cores and forwards them for resolution to WAN-side DNS servers whose IP addresses were provided to the DHCP client in response to an IP lease request. The resolved IP addresses are returned by the WAN-side DNS servers to the primary processing core, which provides them to the requesting secondary core applications or client devices, via the DNS proxy service module. 1. A method of providing Domain Name System (DNS) resolution service in a multi-core platform comprising: generating a second DNS query based on the first DNS query;', 'sending the second DNS query to a DNS server to resolve the second DNS query so as to return a network address result to the primary processing core; and', 'sending the network address result from the primary processing core to the secondary processing core., 'sending a first DNS query from a secondary processing core to the primary processing core;'}2. The method of claim 1 , wherein the primary processing core includes a DNS proxy service module which receives the first DNS query from the secondary processing core and sends the network address result to the secondary processing core.3. The method of claim 1 , wherein generating the second DNS query includes re-addressing the first DNS query to the DNS server.4. The method of comprising generating the first DNS ...

Humanized anti-egfr antibody l4-h3 and coding gene thereof

A humanized anti-EGFR antibody L4-H3 and gene encoding the antibody are disclosed. The antibody is composed of a heavy chain and a light chain. The amino acid sequence of the heavy chain variable region is shown as positions 1-145 of SEQ ID NO: 3, the heavy chain constant region is the heavy chain constant region of the human antibody IgG1, and the amino acid sequence of the light chain is shown as SEQ ID NO: 1.

ARTICULATING BIFURCATED INTEGRATED TRANSITION DUCT ASSEMBLY

A transition duct assembly includes a shared connector, and a plurality of primary cooling pathways for cooling one or more systems or components. Each primary cooling pathway includes a transition duct in fluid communication with the shared connector, and a transition connector in fluid communication with the transition duct. 1. A method of directing fluid flow in a cooling system , comprising:providing a shared connector comprising an articulatable partition; disposing a transition duct in fluid communication with the shared connector; and', 'disposing a transition connector in fluid communication with the transition duct, wherein articulation of the articulatable partition from a first to a second position allows for air flow over most or all of the cooling apparatus., 'providing each of a plurality of primary cooling pathways for cooling one or more systems or components, wherein each of the primary cooling pathways is in fluid communication with the shared connector by2. The method of claim 1 , further comprising forming a plurality of channels within the shared connector using at least one articulatable partition within the shared connector claim 1 , wherein each transition duct is in fluid communication with one of the channels within the shared connector.3. The method of claim 1 , wherein the articulatable partition is articulated or actuated.4. The method of claim 1 , wherein:each transition duct comprises at least a portion that is a rigid material, a flexible material, an articulated portion, a flexible portion, or a combination thereof;the shared connector comprises at least a portion that is a rigid material, a flexible material, an articulated portion, a flexible portion, or a combination thereof; oreach transition connector comprises at least a portion that is a rigid material, a flexible material, an articulated portion, a flexible portion, or a combination thereof.5. The method of claim 1 , further comprising disposing one or more secondary cooling ...

POSITIVE ALLOSTERIC MODULATORS FOR MELANOCORTIN RECEPTORS

Positive allosteric modulators of melanocortin receptors, especially allosteric potentiators of the receptors MC3R and MC4R are described herein. Also provided are pharmaceutical compositions containing the positive allosteric modulators and methods of treating obesity or an obesity-related disorder such as type 2 diabetes, comprising administering an effective amount of the positive allosteric modulator. 5. The method of claim 4 , wherein the obesity is dietary obesity.6. The method of claim 4 , wherein the obesity or obesity-related disorder is mediated by dysfunctional melanocortin receptor signaling.7. The method of claim 6 , wherein the disorder is mediated by dysfunctional melanocortin-4 receptor (MC4R) signaling.8. The method of claim 4 , wherein the obesity is severe or morbid obesity due to MC4R haploinsufficiency.9. The method of claim 8 , the obesity is melanocortin obesity syndrome.10. The method of claim 4 , wherein the obesity-related disorder is type 2 diabetes.15. The method of claim 14 , wherein the melanocortin receptor is a melanocortin-3 receptor.16. The method of claim 14 , wherein the melanocortin receptor is a melanocortin-4 receptor.17. The method of claim 14 , wherein the melanocortin receptor is in vivo.19. The method of claim 18 , wherein the melanocortin receptor is a melanocortin-3 receptor.20. The method of claim 18 , wherein the melanocortin receptor is a melanocortin-4 receptor.21. The method of claim 18 , wherein the melanocortin receptor is in vivo.22. A method for characterizing a compound that modulates melanocortin receptor activity claim 18 , the method comprising the steps of:providing a population of cells expressing at least one melanocortin receptor, the cells being disposed in a vessel containing a luminescent substrate;contacting the cell population with a test compound;contacting the cell population with a melanocortin receptor agonist; anddetermining a cAMP response profile for the test compound;wherein the cAMP response ...

BIOMARKERS FOR CANCER STEM CELLS AND RELATED METHODS OF USE

Novel methods of classifying subjects as candidates for treatment with a cancer associated mesenchymal cell, tumor initiating cancer cell, or cancer stem cell inhibitor treatment and subsequent administration of the cancer associated mesenchymal cell, tumor initiating cancer cell, or cancer stem cell inhibitor are disclosed within. 1. A method of evaluating or treating a subject , comprising:a) optionally, acquiring a subject sample; (i) said first set of genes comprises or consists of:', 'S100A4, SDC2, CYP1B1, FERMT2, CYBRD1, SNAI2, CD44, BIN1, PMP22, CTGF, IGFBP3, ANXA6, MAP1B, TAGLN, ENPP2, FBLN5, PCOLCE, FN1, VIM, PPAP2B, SEM5A, VCAN, NID2, NID1, HAS2, PRRX1, TNFAIP6, CLDN4, FADS2, DDIT4, GNG11, PER1, ISCU, KPNA3, SLC44A1, FKBP5, NR2F1, MLPH, DOCK10, RGS4, IGFBP4; and', '(ii) said second set of genes comprises or consists of:', 'S100A4, SDC2, CYP1B1, FERMT2, CYBRD1, SNAI2, CD44, BIN1, ENPP2, FBLN5, PCOLCE, FN1, VIM, PPAP2B, SEM5A, VCAN, CLDN4, FADS2, DDIT4, GNG11, PER1, ISCU, KPNA3, SLC44A1, FKBP5, IGFBP4; and', '(iii) said third set of genes comprises or consists of:', 'SDC2, CYBRD1, SNAI2, PMP22, CTGF, IGFBP3, ANXA6, MAP1B, TAGLN, PPAP2B, HAS2, NRF2, MLPH, DOCK10, RGS4; and', '(iv) said fourth set of genes comprises or consists of:', 'FERMT2, BIN1, PMP22, CHN1, CTGF, IGFBP3, NID2, CLDN4, CYBRD1, PRR16, ANXA6, PCOLCE, PPAP2B, HAS2, CDH11, MLPH, DOCK10, RGS4, PVRL3, NID2, SLC44A1, FKBP5; and', '(v) said fifth set of genes comprises or consists of:', 'FERMT2, BIN1, PMP22, CHN1, CTGF, IGFBP3, NID2, CLDN4; and', '(vi) said sixth set of genes comprises or consists of:', 'HAS2, BIN1, PCOLCE, FERMT2, CTGF, IGFBP3, NID2, SLC44A1, FKBP5, and MLPH; and, 'b) acquiring a value or values that is a function of the level of gene expression for (each of) a plurality of genes selected from a first and/or second and/or third and/or fourth and or/fifth and/or sixth set of genes, wherein'} (i) classifying said subject; or', '(ii) administering treatment comprising an agent that ...

USING AN UNSUBSTITUTED QUATENARY AMMONIUM SALT COMPOSITION WITH OTHER INGREDIENTS AS A SKIN SANITIZING SOLUTION AND NATURAL SKIN CONDITIONER

A water based, alcohol-free, skin sanitizing solution with a natural skin softener, where the nature of the biocidal enhancer used in the process of making the solution significantly increases efficacy while simultaneously enabling much more economical manufacturing, processing and transportation of the product. Because it is water based, no further moisturizing additives are required, and those with sensitive skin, diabetes, allergies or religious beliefs are able to use the product without concern. 1. A skin sanitizing solution wherein unsubstituted quaternary ammonium salt composition with other ingredients comprises a composition that is alcohol-free , that is highly protonated as a sanitizer with a natural skin conditioner.2. The described unsubstituted quaternary ammonium salt composition with other ingredients according to claim 1 , wherein the composition has a proton count between 4×10and 5.8×10is created by a process involving adding acid to water while stirring vigorously to control the endothermic reaction.3. The solution according to claim 2 , wherein the biocide comprises one or more quaternary ammonium compounds.4. The solution according to claim 2 , wherein the biocide may include a metal sulfate.5. The solution according to claim 2 , wherein the highly protonated claim 2 , non-corrosive claim 2 , nondermatropic ionic carrier may comprise a blend of an inorganic acid and water.6. The solution according to claim 2 , wherein the highly protonated claim 2 , non-corrosive claim 2 , nondermatropic ionic carrier comprises a blend of organic acid and water.7. The solution according to claim 2 , uses the natural moisturizing properties of Carbamide claim 2 , aloe vera and taspine.8. The solution according to claim 2 , where the natural skin moisturizers modifies the allergic reactions by users to dyes and chemicals found in readily available hand sanitizers is avoided.9. The solution according to claim 3 , wherein the quaternary ammonium compound is selected ...

HIGHLY PROTONATED HYDRONIUM AND CARBAMIDE AS A SKIN SANITIZING AND WOUND HEALING SOLUTION

A water-based, alcohol-free, skin sanitizing and wound healing solution with a natural skin softener, where the nature of the biocidal enhancer used in the process of making the solution significantly increases efficacy while simultaneously enabling much more economical manufacturing, processing and transportation of the product. As the present solution is water-based, no further moisturizing additives are required, and those with sensitive skin, diabetes, allergies or religious beliefs are able to use the product without concern. 1. A skin sanitizing and wound healing solution comprising hydronium , having a proton count between about 4×10and about 5.8×10.2. The skin sanitizing and wound healing solution according to claim 1 , further comprising Carbamide.3. The skin sanitizing and wound healing solution according to claim 2 , wherein said Carbamide is supplied in the amount of from about 0.004% to about 4% by weight of the total weight of said skin sanitizing and wound healing solution.4. The skin sanitizing and wound healing solution according to claim 1 , further comprising a blend of an inorganic acid and water.5. The skin sanitizing and wound healing solution according to claim 1 , further comprising a blend of an organic acid and water.6. The skin sanitizing and wound healing solution according to claim 4 , wherein the inorganic acid is selected from the group consisting of Sulfuric acid claim 4 , Hydrochloric acid claim 4 , Nitric acid claim 4 , Phosphoric acid claim 4 , Boric acid claim 4 , Hydrofluoric acid claim 4 , Hydrobromic acid claim 4 , and combinations thereof.7. The skin sanitizing and wound healing solution according to claim 5 , wherein the organic acid is selected from the group consisting of Lactic acid claim 5 , Acetic acid claim 5 , Formic acid claim 5 , Citric acid claim 5 , Oxalic acid claim 5 , Uric acid claim 5 , and combinations thereof.8. The skin sanitizing and wound healing solution according to claim 1 , further comprising a skin ...

Flexible Configuration Hardware Streaming Unit

A processor having a streaming unit is disclosed. In one embodiment, a processor includes a streaming unit configured to load one or more input data streams from a memory coupled to the processor. The streaming unit includes an internal network having a plurality of queues configured to store streams of data. The streaming unit further includes a plurality of operations circuits configured to perform operations on the streams of data. The streaming unit is software programmable to operatively couple two or more of the plurality of operations circuits together via one or more of the plurality of queues. The operations circuits may perform operations on multiple streams of data, resulting in corresponding output streams of data. 1. A processor comprising:a streaming unit configured to load one or more input data streams, wherein the streaming unit includes an internal network having a plurality of queues configured to store streams of data and a plurality of operations circuits configured to perform operations on the streams of data, wherein the streaming unit is programmable to operatively couple two or more of the plurality of operations circuits together via one or more of the plurality of queues.2. The processor as recited in claim 1 , wherein each queue of a first subset of the plurality of queues is internal to a corresponding one of the plurality of operations circuits claim 1 , wherein at least one of the plurality of operations circuits includes a first input queue claim 1 , a second input queue claim 1 , and an output queue claim 1 , the plurality of queues including the first and second input queues and the output queue.3. The processor as recited in claim 2 , wherein the at least one of the plurality of operations circuits is configured to receive a first data stream in its first input queue claim 2 , a second data stream in its second input queue claim 2 , and is configured to produce an output data stream by performing an operation on the first and ...

Hardware Streaming Unit

A processor having a streaming unit is disclosed. In one embodiment, a processor includes one or more execution units configured to execute instructions of a processor instruction set. The processor further includes a streaming unit configured to execute a first instruction of the processor instruction set, wherein executing the first instruction comprises the streaming unit loading a first data stream from a memory of a computer system responsive to execution of a first instruction. The first data stream comprises a plurality of data elements. The first instruction includes a first argument indicating a starting address of the first stream, a second argument indicating a stride between the data elements, and a third argument indicative of an ending address of the stream. The streaming unit is configured to output a second data stream corresponding to the first data stream. 1. A processor comprising:one or more execution units configured to execute instructions of a processor instruction set; anda streaming unit configured to execute a first instruction of the processor instruction set, wherein executing the first instruction comprises the streaming unit loading a first data stream from a memory of a computer system responsive to execution of a first instruction, the first data stream comprising a plurality of data elements, wherein the first instruction includes a first argument indicating a starting address of the first stream and a second argument indicative of an ending address of the first stream;wherein the streaming unit is configured to output a second data stream corresponding to the first data stream.2. The processor as recited in claim 1 , wherein the streaming unit is coupled to provide the second data stream to at least one of the one or more execution units.3. The processor as recited in claim 2 , wherein the second data stream is identical to the first data stream.4. The processor as recited in claim 1 , wherein the streaming unit is further ...

METHOD AND APPARATUS FOR DETECTING AND DISPLAYING AN ALERT DURING PLAYBACK OF A RECORDED SIGNAL

A method of displaying an alert from a broadcast source in an electronic device while the electronic device is not playing back a currently received broadcast signal is disclosed. The method comprises steps of playing back a signal recorded in a first device connected to the electronic device responsive to a user command; detecting an alert from a broadcast source while playing back the recorded signal; and presenting the alert responsive to detecting the alert. 1. A method of displaying an alert from a broadcast source in an electronic device , the method comprising:playing back a signal recorded in a first device connected to the electronic device responsive to a user command;detecting an alert from a broadcast source while playing back the recorded signal; andpresenting the alert responsive to detecting the alert.2. The method of claim 1 , further comprising automatically tuning a channel by the electronic device to receive a broadcast signal from the broadcast source while playing back the recorded signal.3. The method of claim 2 , further comprising if no useable signal is present in the channel claim 2 , automatically tuning another channel by the electronic device until a useable signal is found while playing back the recorded signal.4. The method of claim 1 , further comprising recording the recorded signal from the broadcast source.5. The method of claim 1 , further comprising pausing playback of the recorded signal while presenting the alert.6. The method of claim 5 , further comprising resuming playback of the recorded signal in response to an event.7. The method of claim 6 , wherein the event is one of receiving an end of the alert and receiving a user command to resume the playback of the recorded signal.8. The method of claim 1 , further comprisingresponsive to receiving the alert, displaying a message asking a user whether to pause the playback of the recorded video;if the user indicates to pause the playback, pausing the playback of the recorded ...

Methods of identifying gene isoforms for anti-cancer treatments

Novel methods of classifying subjects as candidates for treatment with agent that inhibits or kills cancer associated mesenchymal cells, tumor initiating cancer cells, or cancer stem cells treatment and subsequent administration of the agent that inhibits or kills cancer associated mesenchymal cells, tumor initiating cancer cells, or cancer stem cells are disclosed within.

Anti-Vasa Antibodies, and Methods of Production and Use Thereof

Anti-VASA antibodies (mAbs), particularly humanized mAbs that specifically bind to VASA with high affinity, are disclosed. The amino acid sequences of the CDRs of the light chains and the heavy chains, as well as consensus sequences for these CDRs, of these anti-VASA mAbs are provided. The disclosure also provides nucleic acid molecules encoding the anti-VASA mAbs, expression vectors, host cells, methods for making the anti-VASA mAbs, and methods for expressing the anti-VASA mAbs. Finally, methods of using the anti-VASA mAbs to isolate and/or purify cells expressing VASA are disclosed. 1. An antibody that specifically binds to a human VASA protein comprising an immunoglobulin heavy chain and an immunoglobulin light chain , (i) a CDR1 region comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 83-88; and/or', '(ii) a CDR2 region comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 89-95; and/or', '(iii) a CDR3 region comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 96-104; and/or;', '(iv) a CDR1 region comprising an amino acid sequence selected from the group consisting of VL CDR1 Motifs 1-2; and/or', '(v) a CDR2 region comprising an amino acid sequence selected from the group consisting of VL CDR2 Motifs 1-3; and/or', '(vi) a CDR3 region comprising an amino acid sequence selected from the group consisting of VL CDR3 Motifs 1-5; and, 'a) wherein the variable region of said light chain comprises (i) a CDR1 region comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 105-112;', '(ii) a CDR2 region comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 113-121; and/or', '(iii) a CDR3 region comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 122-131; and/or', '(iv) a CDR1 region comprising an amino acid sequence selected from the group consisting of VH CDR1 Motifs 1-2; and/or', '(v) a ...

MECHANISM TO BLOCK WEB SITES USING RETURN TRAFFIC

A method and apparatus for blocking websites using return traffic are described including receiving a request for access to a blocked website from a user, determining if the request includes a first domain name, transmitting the request if the request does not include the first domain name, receiving return traffic in response to the transmitted request, determining if a second domain name in the return traffic matches the first domain name, blocking access to the website if the first domain name and the second domain name match and discarding the return traffic if the access is blocked. 1. A method for blocking websites using return traffic , said method comprising:receiving a request for access to a blocked website from a user;determining if said request includes a first domain name;transmitting said request if said request does not include said first domain name;receiving return traffic in response to said transmitted request;determining if a second domain name in said return traffic matches said first domain name;blocking access to said website if said first domain name and said second domain name match; anddiscarding said return traffic if said access is blocked.2. The method according to further comprising:determining, based on said first domain name, if said website is blocked; andblocking access to said website if said website is determined to be blocked.3. The method according to claim 1 , further comprising:determining, based on said first domain name, if said website is blocked;transmitting said request if said website in said request is determined not to be blocked;receiving return traffic in response to said transmitted request;forwarding said return traffic to said user.4. The method according to claim 1 , further comprising transmitting a message to said user that access to the requested website is blocked.5. The method according to wherein said blocking is determined by parental controls.6. An apparatus gateway for blocking websites using return ...

METHOD AND APPARATUS FOR RE-INSERTING A COMMERCIAL DURING PLAYBACK OF A RECORDED PROGRAM

A method of playing back, by an electronic device, a recorded program without a first commercial, the recorded program recorded from a first program having the first commercial inserted therein is disclosed. The method comprises steps of obtaining location information of the first commercial in the first program responsive to a command to play back the recorded program; inserting a second commercial at a first location according to the location information of the first commercial; and playing back the recorded program with the inserted second commercial. 1. A method of playing back , by an electronic device , a recorded program without a first commercial , the recorded program recorded from a first program having the first commercial inserted therein , the method comprising:obtaining location information of the first commercial in the first program responsive to a command to play back the recorded program;inserting a second commercial at a first location according to the location information of the first commercial; andplaying back the recorded program with the inserted second commercial.2. The method of claim 1 , wherein the second commercial has the same length as the first commercial.3. The method of claim 1 , wherein the first commercial is different from the second commercial.4. The method of claim 1 , further comprising receiving from a server the second commercial.5. The method of claim 4 , further comprising requesting the server to send the second commercial.6. The method of claim 5 , wherein the requesting step comprises sending a request including an identification of the first commercial to the server.7. The method of claim 1 , wherein the inserting and playing back steps comprise playing back of the recorded program without the second commercial inserted claim 1 , stops playing back the recorded program claim 1 , playing back the second commercial claim 1 , and upon completion of the playback of the second commercial claim 1 , resuming playback of the ...

TELECENTRIC LENS ASSEMBLY PROVIDING A COLLIMATED LIGHT SPACE

Systems and methods for imaging a target are provided. A system includes a detector and a substantially bitelecentric lens assembly positioned between the detector and the target. A first optical assembly is configured to focus light received from the substantially bitelecentric lens assembly onto the detector. The substantially bitelecentric lens assembly and the first optical assembly are configured to produce a collimated light space between the substantially bitelecentric lens assembly and the first optical assembly. A second optical assembly is positioned within the collimated light space. 120-. (canceled)21. An imaging system comprising:a detector;a lens assembly, positioned between the detector and a target;a first optical assembly configured to focus light received from the lens assembly onto the detector, the lens assembly and the first optical assembly being configured to produce a collimated light space between the lens assembly and the first optical assembly; anda beam splitter positioned within the collimated light space.22. The imaging system of claim 21 , wherein the lens assembly is substantially image-space telecentric.23. The imaging system of claim 21 , wherein the beam splitter comprises a polychroic mirror.24. The imaging system of claim 23 , wherein the polychroic mirror comprises a bichroic mirror.25. The imaging system of claim 21 , further comprising a second optical assembly positioned within the collimated light space.26. The imaging system of claim 25 , wherein the second optical assembly is configured to be modular claim 25 , such that the second optical assembly can be removed and replaced with a third optical assembly without disturbance of the detector claim 25 , the lens assembly claim 25 , and the first optical assembly.27. The imaging system of claim 26 , wherein each of the second optical assembly and the third optical assembly comprise at least one filter configured in a filter changer.28. The imaging system of claim 24 , wherein ...

ARTICULATING BIFURCATED INTEGRATED TRANSITION DUCT ASSEMBLY

A transition duct assembly includes a shared connector, and a plurality of primary cooling pathways for cooling one or more systems or components. Each primary cooling pathway includes a transition duct in fluid communication with the shared connector, and a transition connector in fluid communication with the transition duct. 1. A transition duct assembly , comprising:a shared connector; and a transition duct in fluid communication with the shared connector; and', 'a transition connector in fluid communication with the transition duct., 'a plurality of primary cooling pathways for cooling one or more systems or components, wherein each primary cooling pathway comprises2. The assembly of claim 1 , further comprising at least one partition forming a plurality of channels within the shared connector claim 1 , wherein each transition duct is in fluid communication with one of the channels within the shared connector.3. The assembly of claim 1 , wherein the transition ducts partially extend into the shared connector.4. The assembly of claim 1 , wherein the partition is fixed claim 1 , articulated or actuated.5. The assembly of claim 1 , wherein each transition duct comprises at least a portion that is a rigid material claim 1 , a flexible material claim 1 , an articulated portion claim 1 , a flexible portion claim 1 , or a combination thereof.6. The assembly of claim 1 , further comprising one or more secondary cooling pathways claim 1 , wherein each of the one or more secondary cooling pathways comprises a conduit in fluid communication with the transition duct of one of the primary cooling pathways.7. The assembly of claim 6 , wherein each conduit comprises at least a portion that is a rigid material claim 6 , a flexible material claim 6 , an articulated portion claim 6 , a flexible portion claim 6 , or a combination thereof.8. The assembly of claim 6 , wherein each conduit is operably configured to be placed in fluid communication with a distributed cooling device.9. ...

Active Thermal Management for Fire-Tolerant Drive Systems

The present invention includes a thermal management system and method including: a drive shaft; one or more fans or impellers in fluid communication with at least a portion of the drive shaft; and one or more air management baffles configured to direct air flow between the impeller and the portion of the drive shaft. In one embodiment, the system and method further includes insulation positioned about the at least a portion of the drive shaft. 1. A thermal management system , comprising:a drive shaft;one or more fans or impellers in fluid communication with at least a portion of the drive shaft; andone or more air management baffles configured to direct air flow between the impeller and the at least a portion of the drive shaft.2. The system of claim 1 , wherein the portion in fluid communication with the one or more fans or impellers is at least one of a proximate portion claim 1 , a distal portion claim 1 , or an intermediate portion of the drive shaft.3. The system of claim 1 , wherein the one or more fans or impellers are connected to the drive shaft claim 1 , or are powered independently of the drive shaft.4. The system of claim 1 , wherein the drive shaft is a tail rotor drive shaft claim 1 , a main rotor shaft claim 1 , a proprotor shaft claim 1 , a propeller shaft claim 1 , or a wind-turbine shaft.5. The system of claim 1 , further comprising the one or more air management baffles that surround at least a portion of the drive shaft.6. The system of claim 5 , wherein the one or more air management baffles comprise a rigid material claim 5 , a flexible material claim 5 , or combinations thereof.7. The system of claim 1 , wherein at least a portion of the draft shaft comprises a composite material.8. The system of claim 1 , further comprising insulation positioned about at least a portion of the drive shaft.9. The system of claim 8 , wherein the insulation surrounds the portion of the drive shaft adjacent an engine compartment.10. The system of claim 8 , ...

Redundant Cooling System

A cooling apparatus includes a shared cooling device for one or more systems or components, and a plurality of primary cooling pathways. Each of the primary cooling pathways includes a transition duct and a fan. The transition duct is in fluid communication with the shared cooling device. The fan is in fluid communication with the transition duct. 1. A cooling apparatus , comprising:a shared cooling device for one or more systems or components; and a transition duct, wherein the transition duct is in fluid communication with the shared cooling device; and', 'a fan, wherein the fan is in fluid communication with the transition duct., 'a plurality of primary cooling pathways, wherein each of the primary cooling pathways comprises2. The apparatus of claim 1 , further comprising a shared connector in fluid communication with the shared cooling device;wherein the shared connector comprises a plurality of channels; andwherein each of the primary cooling pathways is operably configured to be in fluid communication with one of the channels.3. The apparatus of claim 2 , further comprising a partition within the shared connector claim 2 , wherein the partition separates each of the channels of the plurality of channels from all of the other channels.4. The apparatus of claim 3 , wherein the partition is articulated or actuated to move to place substantially all of the shared cooling device in fluid communication with one primary cooling pathway of the plurality of primary cooling pathways.5. The apparatus of claim 3 , wherein the shared cooling device comprises a plurality of cores claim 3 , wherein each core is configured to cool one of the one or more systems or components claim 3 , and wherein each core is oriented to the partition or the transition ducts such that each core is in fluid communication with at least one of the plurality of primary cooling pathways.6. The apparatus of claim 2 , wherein the shared connector comprises at least a portion that is a rigid material ...

AUTONOMOUS LOADING/UNLOADING OF CARGO

Cargo may be optimally placed within a cargo hold using a cargo mover comprising a flexible conveyor belt extending from a ground location to a cargo hold, data defining a dimensional map of available space existing within the cargo hold for placement of cargo, a conveyor controller operatively in communication with the flexible conveyer belt and comprising packing software, and a smart loader comprising a predetermined set of scanning sensors operative to scan the cargo hold and a processor operatively in communication with the predetermined set of sensors and the conveyor controller. An interior of the cargo hold is scanned to create a dimensional map of the cargo hold and cargo placed onto the flexible conveyor belt where certain of each piece is cargo's physical dimensions are scanned. The processor compares the scanned cargo hold data set with the cargo's physical dimensions as well as with an order in which that piece of cargo will arrive at the smart loader to determine the placement of each piece of cargo. As each piece of cargo is placed into cargo hold, the smart loader continues to scan and update the dimensional map of the cargo hold to determine where each subsequent piece of cargo will be placed in the cargo hold. 1. A cargo mover , comprising:a. a flexible conveyor belt, sized to extend from a ground location to a cargo hold;b. data defining a dimensional map of available space existing within the cargo hold for placement of cargo;c. a predetermined set of sensors disposed proximate a head end of the flexible conveyor belt;d. a conveyor controller operatively in communication with the flexible conveyer belt and comprising packing software executable within the conveyor controller, the conveyor controller operatively in communication with the predetermined set of sensors; i. a predetermined set of scanning sensors disposed proximate to and operative to scan the cargo hold and return data representative of physical space within the cargo hold;', 'ii. a ...

METHOD AND APPARATUS FOR REPLACING A COMMERCIAL IN A RECORDED PROGRAM

A method of playing back, by an electronic device, a recorded program having a first commercial inserted therein is disclosed. The method comprises steps of if a date of playing back the recorded program is less than a date associated with the recorded program, playing back the recorded program including the first commercial; and if the date of playing back the recorded program is more than the associated date, replacing the first commercial in the recorded program with a second commercial and playing back the recorded program including the second commercial. 1. A method of playing back , by an electronic device , a recorded program having a first commercial inserted therein , the method comprising:if a date of playing back the recorded program is less than a date associated with the recorded program, playing back the recorded program including the first commercial; andif the date of playing back the recorded program is more than the associated date, replacing the first commercial in the recorded program with a second commercial and playing back the recorded program including the second commercial.2. The method of claim 1 , wherein the associated date is a date of recording the recorded program plus a predetermined number of days.3. The method of claim 1 , wherein the associated date is a date included in metadata associated with the recorded program.4. The method of claim 3 , further comprising receiving the metadata and the recorded program from a broadcast source.5. The method of claim 3 , wherein the metadata indicates whether the first commercial can be replaced and if the date of playing back the recorded program is more than the associated date and the metadata indicates that the first commercial can be replaced claim 3 , replacing the first commercial in the recorded program with the second commercial and playing back the recorded program including the second commercial.6. The method of claim 3 , wherein the date included in the metadata is the expiration ...

ANTI-VASA ANTIBODIES, AND METHODS OF PRODUCTION AND USE THEREOF

Anti-VASA antibodies (mAbs), particularly humanized mAbs that specifically bind to VASA with high affinity, are disclosed. The amino acid sequences of the CDRs of the light chains and the heavy chains, as well as consensus sequences for these CDRs, of these anti-VASA mAbs are provided. The disclosure also provides nucleic acid molecules encoding the anti-VASA mAbs, expression vectors, host cells, methods for making the anti-VASA mAbs, and methods for expressing the anti-VASA mAbs. Finally, methods of using the anti-VASA mAbs to isolate and/or purify cells expressing VASA are disclosed. 1. A cell transformed with a nucleic acid molecule encoding a heavy chain or light chain of an antibody that specifically binds to a human VASA protein comprising an immunoglobulin heavy chain and an immunoglobulin light chain , (i) a CDR1 region comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 83-88;', '(ii) a CDR2 region comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 89-95; and', '(iii) a CDR3 region comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 96-104; and, 'a) wherein the variable region of said light chain comprises (i) a CDR1 region comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 105-112;', '(ii) a CDR2 region comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 113-121; and', '(iii) a CDR3 region comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 122-131., 'b) wherein the variable region of said heavy chain comprises2. The cell of claim 1 , wherein said nucleic acid molecule is selected from the group consisting of a cloning vector claim 1 , an expression vector claim 1 , a heterologous recombination vector claim 1 , and a viral integration vector.3. The cell of claim 1 , wherein said cell is a mammalian cell.4. The cell of claim 3 , wherein said cell is a rodent cell.5. ...

SEALING LOUVERS FOR ROOF STRUCTURES

Louvered roof systems are provided with one or more louvers. Such louvers can be combined in an assembly that is movable between an open condition and a closed condition. In the closed condition, louvers in the assembly engage one another. In such engagement, a leg extending generally transversely from one louver may include a wing that extends generally transversely to the leg and that abuts a surface of an adjacent louver. Additionally or alternatively, in such engagement, a leg extending transversely from one louver may be received in a notch in an adjacent louver. 1. A louvered roof system comprising: [ (i) a first end;', '(ii) a first leg having a first proximal portion and a first distal portion, the first leg extending generally transverse to the first end and from the first proximal portion to the first distal portion; and', '(iii) a first notch positioned at the first end; and, '(A) a first louver comprising, (i) a second end;', '(ii) a second leg having a second proximal portion and a second distal portion, the second leg extending generally transverse to the second end and from the second proximal portion to the second distal portion;', '(iii) a wing extending generally transverse to a longitudinal axis of the second leg and from the second distal portion of the second leg; and', '(iv) a second notch positioned at the second end;, '(B) a second louver comprising], 'a plurality of louvers configured for movement between an open position and a closed position, the plurality of louvers comprising at leastwherein in the closed position, the first louver and the second louver are engaged with one another such that the first distal portion of the first leg is received in the second notch, the second distal portion of the second leg is received in the first notch, and the wing of the second louver abuts the first end of the first louver, wherein the first louver and the second louver being so engaged with one another obstructs passage of liquid between the first ...

METHOD TO SELECTIVELY ADD PRIORITY TAGGING TO NETWORK TRAFFIC

A gateway device communicates with a client device on a local area network. The gateway device receives a dynamic host configuration protocol (DHCP) request from the client device; wherein the DHCP request includes information indicating whether, or not, the client device supports quality of service (QoS) treatment; and if the client device supports QoS treatment, the gateway device sends packets destined for the client device with QoS priority tagging information; and if the client device does not support QoS treatment, the gateway device sends packets destined for the client device without QoS priority tagging information. 1. A method for use in a gateway device , the method comprising:communicating with a client device on a local area network for determining whether, or not, Layer 2 Quality of Service treatment is supported by the client device; andadjusting a frame size subsequently communicated with the client device in accordance with the determined Quality of Service treatment.2. The method of claim 1 , wherein the adjusting step includes the steps of:if the client device does not support L2 Quality of Service treatment, subsequently communicating the frame without priority tagging information with the client device; andif the client device does support L2 Quality of Service treatment, subsequently communicating the frame with priority tagging information with the client device.3. The method of claim 2 , wherein the frame without priority tagging information is an Untagged Frame as defined in accordance with IEEE 802.3 and the frame with priority tagging information is a Tagged Frame as defined in accordance with IEEE 802.1Q.4. The method of claim 1 , wherein the communicating step includes the steps of:connecting to the client device on the local area network;receiving identifier information from the client device; anddetermining from the received identifier information whether or not the client device supports L2 Quality of Service treatment.5. The method ...

HIGHLY PROTONATED HYDRONIUM AND PEROXYMONOSULFURIC ACID AS A SANITIZING SOLUTION

A water-based, alcohol-free, skin and hard surfaces sanitizing solution with a natural skin softener, where the nature of the biocidal enhancer used in the process of making the solution significantly increases efficacy while simultaneously enabling much more economical manufacturing, processing and transportation of the product. As the present solution is water-based, no further moisturizing additives are required, and those with sensitive skin, diabetes, allergies or religious beliefs are able to use the product without concern. 1. A sanitizing solution comprising hydronium having a proton count between 4×10and 5.8×10 , inorganic acid , Hydrogen peroxide and water.2. The sanitizing solution according to claim 1 , wherein the inorganic acid is sulfuric acid.3. The sanitizing solution according to claim 1 , further comprising a thickener configured to make a gel formula of the solution.4. The sanitizing solution according to claim 3 , wherein the thickener is Xanthan gum.5. A sanitizing solution comprising hydronium having a proton count between 4×10and 5.8×10 claim 3 , sulfuric acid claim 3 , hydrogen peroxide of about 35% by weight of the weight of said sulfuric acid and water.6. The sanitizing solution according to claim 5 , further comprising a thickener configured to make a gel formula of the solution.7. The sanitizing solution according to claim 6 , wherein8. A sanitizing solution comprising:{'sup': 20', '23, 'a peroxymonosulfuric acid formed by mixing water, sulfuric acid, hydrogen peroxide of about 35% by weight of the weight of said sulfuric acid in hydronium having a proton count between 4×10and 5.8×10.'}9. The sanitizing solution according to claim 8 , further comprising a thickener configured to make a gel formula of the solution.10. The sanitizing solution according to claim 9 , wherein the thickener is Xanthan gum. This continuation-in-part application claims the benefit of priority from application U.S. Ser. No. 14/926,148 filed Oct. 29, 2015. Said ...

OPTIMIZING WIRELESS LOCAL AREA NETWORK COMMUNICATIONS

A method and apparatus for optimizing wireless local area network communications are described including receiving a request, from a wireless device, to join a multicast group in order to receive multicast data, determining if the request is a request from a subsequent wireless device for the same multicast data, converting the multicast data to unicast data, if the request is not from a subsequent wireless device or the request is not for the same multicast data and transmitting the converted data to the wireless device that requested the multicast data. 1. A method for optimizing wireless local area network communications , said method comprising:receiving a request, from a wireless device, to join a multicast group in order to receive multicast data;determining if said request is a request from a subsequent wireless device for the same multicast data;converting said multicast data to unicast data, if said request is not from a subsequent wireless device or said request is not for the same multicast data; andtransmitting said converted data to said wireless device that requested said multicast data.2. The method according to claim 1 , further comprising multicasting said multicast data if request is from a subsequent wireless device and said request is for the same multicast data.3. An apparatus for optimizing wireless local area network communications claim 1 , comprising:means for receiving a request, from a wireless device, to join a multicast group in order to receive multicast data;means for determining if said request is a request from a subsequent wireless device for the same multicast data;means for converting said multicast data to unicast data, if said request is not from a subsequent wireless device or said request is not for the same multicast data; andmeans for transmitting said converted data to said wireless device that requested said multicast data.4. The apparatus according to claim 3 , further comprising means for multicasting said multicast data ...

Concrete Pier Foundation Anchor Bolt Support and Chamfer Form

Embodiments of the Concrete Form include a form tube, chamfer disk, and one or more cross-members. The cross-members are comprised of a center pivot aperture, two bolt guides, which are formed by the cross-members, end clamps, and an optional clamp. The chamfer disk is a disk that sits atop of the form tube and forms side chamfers in positive relief when placed upon the form tube when the concrete cures. The optional conduit clamp can be used to hold any conduit, tube or any other item during the pour. In another embodiment of the Concrete Form is comprised of a form tube, chamfer disk, end clamps, four or more bottom slide arms, and four or more top slide arms. 1a. a form tube,b. a chamfer disk,c. one or more end clamps, andd. one or more cross-members.. A concrete form comprised of This application is a continuation-in-part of pending application Ser. No. 14/197,496 filed on Mar. 5, 2014 and claims benefit of application Ser. No. 14/197,496. Application Ser. No. 14/197,496 in turn claims benefit of U.S. Provisional Application No. 61/773,086, filed on Mar. 5, 2013. U.S. Non-Provisional patent application Ser. No. 14/197,496 and U.S. Provisional Patent Application No. 61/773,086 are incorporated by reference in its entirety for all purposes as if fully set forth herein.Not applicableThe field of the embodiments of the Concrete Form is concrete forms used to contain concrete during the curing process of the concrete.The background of the embodiments of the Concrete Form is the broad use of concrete forms. When forming a support pylon for objects including lamp posts, signs, and structural piers, it is common to use concrete form tubes to contain the concrete while it is curing. Usually the form is a simple, water-resistant tube that the concrete is poured into and allowed to contain the concrete during cure. This simple form does not permit finer finishing of the concrete including the formation of a chamfer on the outer edges of the concrete.In summary, the ...

COMPOSITIONS AND METHODS FOR TREATING CANCER

This present invention compositions and methods of treating cancer and methods of accessing/monitoring the responsiveness of a cancer cell to a therapeutic compound. 143.-. (canceled)44. A method of treating cancer in a subject , comprising:a) determining whether a cell of said cancer is deficient in FANCA, FANCB, FANCD2, FANCE, FANCF, FANCG, or FANCL as compared to a wild type control; andb) if said cell is deficient as determined in step a), administering to said subject an inhibitor specific for at least one different DNA repair pathway than the Fanconi Anemia (FA) pathway selected from the group consisting of: homologous recombination and crosslinking repair (FA/HR), mismatch repair (MMR), nucleotide excision repair (NER), translesion DNA synthesis (TLS), and DNA damage response controls (DDR), wherein said inhibitor is an siRNA.45. The method of claim 44 , further comprising step c) administering a chemotherapeutic agent or radiation therapy to said subject.46. The method of claim 45 , wherein said chemotherapeutic agent is selected from the group consisting of a crosslinking agent claim 45 , a strand break agent claim 45 , an alkylating agent claim 45 , an anti-metabolite agent claim 45 , a microtubule disruptor claim 45 , a radiomimetic agent claim 45 , a radiosensitizer claim 45 , an intercalator claim 45 , a DNA replication inhibitor claim 45 , an anthracycline claim 45 , an etoposide claim 45 , and a topoisomerase II inhibitor.47. The method of claim 44 , wherein said cell is deficient in FANCA claim 44 , FANCD2 claim 44 , FANCE claim 44 , FANCF claim 44 , or FANCG.48. The method of claim 44 , wherein said inhibitor is an ATM inhibitor.49. The method of claim 44 , wherein said inhibitor is a CHK1 inhibitor.50. The method of claim 44 , wherein said cell is deficient in FANCA.51. The method of claim 44 , wherein said cell is deficient in FANCB.52. The method of claim 44 , wherein said cell is deficient in FANCD2.53. The method of claim 44 , wherein said cell ...

Compositions and methods for treating cancer

This present invention compositions and methods of treating cancer and methods of accessing/monitoring the responsiveness of a cancer cell to a therapeutic compound.

Anti-vasa antibodies, and methods of production and use thereof

Anti-VASA antibodies (mAbs), particularly humanized mAbs that specifically bind to VASA with high affinity, are disclosed. The amino acid sequences of the CDRs of the light chains and the heavy chains, as well as consensus sequences for these CDRs, of these anti-VASA mAbs are provided. The disclosure also provides nucleic acid molecules encoding the anti-VASA mAbs, expression vectors, host cells, methods for making the anti-VASA mAbs, and methods for expressing the anti-VASA mAbs. Finally, methods of using the anti-VASA mAbs to isolate and/or purify cells expressing VASA are disclosed.

Floating Ducts

A duct interface system and method includes a duct having a first end and a second end; a first receptacle for the first end of the duct and/or a second receptacle for the second end of the duct; and one or more first seals between the first end of the duct and the first receptacle and/or one or more second seals between the second end of the duct and the second receptacle. 1. A duct interface system , comprising:a duct having a first end and a second end;a first receptacle for the first end of the duct and/or a second receptacle for the second end of the duct; andone or more first seals between the first end of the duct and the first receptacle and/or one or more second seals between the second end of the duct and the second receptacle.2. The system of claim 1 , wherein the one or more first seals are operable to allow motion of the first end of the duct relative to the first receptacle and/or the one or more second seals are configured to allow motion of the second end of the duct relative to the second receptacle.3. The system of claim 2 , wherein the motion does not substantially break a seal formed by the one or more first seals and/or the one or more second seals.4. The system of claim 1 , wherein the first end of the duct and the first receptacle and/or the second end of the duct and the second receptacle are coupled to an inlet port.5. The system of claim 4 , wherein the first end of the duct is coupled to the first receptacle and the second end of the duct is coupled to the second receptacle without any fasteners.6. The system of claim 4 , wherein the first end of the duct is coupled to the first receptacle and/or the second end of the duct is coupled to the second receptacle without any clamps.7. The system of claim 1 , wherein the first seal is the only device coupling the first end of the duct to the first receptacle and/or the second seal is the only device coupling the second end of the duct to the second receptacle.8. The system of claim 1 , wherein ...

DRUG-POLYMER AMORPHOUS SOLID DISPERSIONS USING LINEAR POLY(ACRYLIC ACID) POLYMERS

An amorphous solid dispersion includes a linear poly(acrylic acid) and an active pharmaceutical ingredient. The linear poly(acrylic acid) used to form the amorphous solid dispersion has a Brookfield viscosity of at least 100 cP at 25° C. A method of forming such an amorphous solid dispersion of an active pharmaceutical ingredient includes forming a liquid dispersion of a linear poly(acrylic acid), an active pharmaceutical ingredient, and a solvent system, the linear poly(acrylic acid) having a Brookfield viscosity at 25° C. of at least 100 cP and evaporating the solvent system from the liquid dispersion to form an amorphous solid dispersion. 1. An amorphous solid dispersion comprising:at least 10 wt. % of a linear poly(acrylic acid); andan active pharmaceutical ingredient, wherein:the linear poly(acrylic acid) has a Brookfield viscosity at 25° C. of at least 100 cP,the linear poly(acrylic acid) and the active pharmaceutical ingredient together comprise at least 80 wt. % of the amorphous solid dispersion, and{'sub': '3', 'the linear poly(acrylic acid) has a weight average molecular weight, as determined by size exclusion chromatography on a liquid sample of 1.5 g/L polymer in 0.1M NaNOat pH 10, of least 200,000 Da.'}2. The amorphous solid dispersion of claim 1 , wherein a ratio by weight of active pharmaceutical ingredient:poly(acrylic acid) in the amorphous solid dispersion is at least or up to 6:1.3. The amorphous solid dispersion of claim 1 , wherein the Brookfield viscosity at 25° C. of the linear poly(acrylic acid) is at least 200 cP.46-. (canceled)7. The amorphous solid dispersion of claim 1 , wherein the linear poly(acrylic acid) and the active pharmaceutical ingredient together comprise at least 90 wt. % of the amorphous solid dispersion.8. The amorphous solid dispersion of claim 1 , wherein the amorphous solid dispersion comprises 0-10 wt. % water.9. The amorphous solid dispersion of claim 1 , wherein the active pharmaceutical ingredient is in BCS class II ...

Concrete Pier Foundation Anchor Bolt Support and Chamfer Form

a Embodiments of the Concrete Form include a form tube, chamfer disk, and one or more form cross-members. The form cross-members are comprised of a center pivot, two bolt guides, which are formed by the cross-members, and an optional clamp. The chamfer disk is a disk that sits atop of the form tube and forms side chamfers when placed upon the form tube when the concrete cures. The chamfer disk is a separate formed or molded piece that will sit on top of the tube form in order to form a chamfer in the concrete. The chanfer disk is a ring-shaped device with the chamfer formed in positive relief under the ring of the chamfer disk. The optional clamp can be used to hold any conduit, tube or any other item during the pour.

Extremely high speed data transfer and communications

A pinless connector for subsea data communications comprises contactless connectivity data transmitter coupler, comprising one or more first solid state contactless connectivity data transmitters, and contactless connectivity data receiver coupler, comprising one or more first solid state contactless connectivity data receivers, which can allow for rapid collection and/or download data from subsea vehicles or sensors without having to plug in an external connector or physically remove the data recorder from the unit. Typically, these are operative at a low power level, e.g. less than or around 50 milliwatts, at an extremely high data transfer rate or around 5 GBits/second. The connectors may be incorporated into a subsea system comprising two subsea devices. A slip ring system may similarly comprise one or more first solid state contactless connectivity data transmitters and one or more first solid state contactless connectivity data receivers.

Slip Ring With High Data Rate Sensors

A pinless connector for subsea data communications comprises contactless connectivity data transmitter coupler, comprising one or more first solid state contactless connectivity data transmitters, and contactless connectivity data receiver coupler, comprising one or more first solid state contactless connectivity data receivers, which can allow for rapid collection and/or download data from subsea vehicles or sensors without having to plug in an external connector or physically remove the data recorder from the unit. Typically, these are operative at a low power level, e.g. less than or around 50 milliwatts, at an extremely high data transfer rate or around 5 GBits/second. The connectors may be incorporated into a subsea system comprising two subsea devices. A slip ring system may similarly comprise one or more first solid state contactless connectivity data transmitters and one or more first solid state contactless connectivity data receivers. 1. A slip ring system , comprising: i. a sensor trigger; and', 'ii. a first solid state contactless connectivity transmitter operatively coupled to the sensor trigger and configured to be operative at an extremely high data transfer rate; and, 'a. a rotatable ring comprisingb. a non-contact stationary sensor responsive to the sensor trigger and disposed at a predetermined position proximate an outside diameter of the rotatable ring, the non-contact stationary sensor comprising a first solid state contactless connectivity receiver configured to exchange data with the first solid state contactless connectivity transmitter at a low power level at the extremely high data transfer rate when disposed proximate to the first solid state contactless connectivity transmitter.2. The slip ring system if claim 1 , wherein the rotatable ring comprises a plurality of rotatable rings claim 1 , each rotatable ring comprising:i. a sensor trigger; andii. a first solid state contactless connectivity transmitter operatively coupled to the sensor ...

Passive Gas-Leak Management System

A gas-leak management system including a primary duct; and a leak-management duct, at least a portion of the leak-management duct surrounding at least a portion of the primary duct, wherein the leak-management duct includes a gap between the portion of the primary duct and the portion of the leak-management duct, and including one or more vent holes in fluid communication with the gap. 1. A gas-leak management system , comprising:a primary duct; anda leak-management duct, at least a portion of the leak-management duct surrounding at least a portion of the primary duct, wherein the leak-management duct forms a gap between the portion of the primary duct and the portion of the leak-management duct, and comprising one or more vent holes in fluid communication with the gap.2. The system of claim 1 , further comprising one or more standoff brackets mounted between the primary duct and the leak-management duct.3. The system of claim 1 , wherein the gap comprises an air gap.4. The system of claim 1 , further comprising a porous material disposed within all or part of the gap.5. The system of claim 1 , wherein:the primary duct and/or the leak-management duct comprise a rigid material, a flexible material, or combinations thereof; orthe primary duct comprises a metallic material, a non-metallic material, or a combination thereof; or.the leak-management duct comprises a thin-wall insulation.6. The system of claim 1 , wherein the one or more vent holes are located to vent a gas at one or more selected locations.7. The system of claim 6 , wherein the one or more selected locations are selected to direct the gas to one or more areas where a presence claim 6 , temperature and/or pressure of the gas is acceptable.8. The system of claim 1 , wherein the one or more vent holes are oriented to vent a gas in one or more selected directions.9. The system of claim 8 , wherein the one or more selected directions are selected to direct the gas to one or more areas where a presence claim 8 ...

THERAPEUTIC COMPOSITIONS, COMBINATIONS, AND METHODS OF USE

This invention relates to methods comprising administering a FAK inhibitor and an immunotherapeutic agent such as anti-PD-1 or anti-PD-L1; that are useful in the treatment of abnormal cell growth, such as cancer, in mammals, especially humans. 1. A method for treating a human subject suffering from cancer comprising administering a FAK inhibitor in combination with an immunotherapeutic agent.2. The method of claim 1 , wherein the cancer is a solid tumor claim 1 , soft tissue tumor claim 1 , metastasis claim 1 , or non-solid cancer.3. The method of claim 2 , wherein the cancer is solid tumor.4. The method of claim 3 , wherein the solid tumor is a malignancy of an organ.5. The method of claim 1 , wherein the cancer is a mesothelioma; neurofibromatosis; renal cancer; lung cancer claim 1 , non small cell lung cancer; liver cancer; thyroid cancer; ovarian cancer; breast cancer; a nervous system tumor; schwannoma; meningioma; schwannomatosis; neuroma acoustic;adenoid cystic carcinoma; ependymoma; or ependymal tumors.6. The method of claim 1 , wherein the cancer is mesothelioma claim 1 , breast cancer claim 1 , ovarian cancer claim 1 , lung cancer claim 1 , or a non-hematologic malignancy.7. The method of claim 1 , wherein the cancer is melanoma claim 1 , colorectal cancer claim 1 , leukemia claim 1 , adenocarcinoma claim 1 , or a solid tumor.8. The method of claim 1 , wherein the FAK inhibitor is administered orally.9. The method of claim 8 , wherein the FAK inhibitor is VS-4718 claim 8 , VS-5095 claim 8 , VS-6062 claim 8 , VS-6063 claim 8 , BI 853520 claim 8 , or GSK2256098.10. The method of claim 9 , wherein the FAK inhibitor is VS-4718.11. The method of claim 9 , wherein the FAK inhibitor is VS-6063.12. The method of claim 8 , wherein the FAK inhibitor is administered at least once a day.13. The method of claim 12 , wherein the FAK inhibitor is administered once a day.14. The method of claim 12 , wherein the FAK inhibitor is administered twice a day.15. The method of ...

ELECTRICAL TERMINAL FOR TERMINATING A WIRE

An electrical terminal () having an electrical contact () and a crimp barrel () configured to be crimped around an end of a wire. The crimp barrel () includes a base () and opposing side walls () that define an opening () of the crimp barrel (). The side walls () extend outwardly from the base () to ends () and include base segments () and end segments (). A sealing wing () extends from the end of at least one of the side walls (). The side walls () are configured to be folded over the wire when crimped such that a gap is defined between the end segment () and the base segment () of at least one of the side walls (). The sealing wing () is configured to extend within the gap between the end segment () and the base segment () when the side walls () are crimped over the end of the wire. 1. An electrical terminal for terminating a wire having at least one exposed conductor and an electrical insulation layer , the electrical terminal comprising:an electrical contact; anda crimp barrel extending from the electrical contact, the crimp barrel comprising a first portion configured to be crimped around the electrical insulation layer, and a second portion configured to be crimped around the at least one exposed conductor, wherein when crimped, the second portion substantially encases the at least one exposed conductor.2. The electrical terminal of claim 1 , further comprising a sealant within the second portion that substantially prevents moisture contact with the at least one exposed conductor when the second portion is crimped around the at least one exposed conductor.3. The electrical terminal of claim 1 , wherein the crimp barrel extends a length from a contact end to a wire end claim 1 , and wherein when the crimp barrel has been crimped around the end of the wire claim 1 , at least a portion of the crimp barrel tapers outwardly as the crimp barrel extends from the contact end to the wire end.4. The electrical terminal of claim 1 , wherein the first portion defines a ...

SYSTEM FOR AUTHORIZING ELECTRONIC COMMUNICATION OF CONFIDENTIAL OR PROPRIETARY DATA TO EXTERNAL ENTITIES

A platform for providing authorization of electronic communication of secure data to external entities, e.g., vendors, third parties or the like based on an assessment of the data risk associated with communicating the data to the external entity. The secure data that is to be communicated, in the form of specific data items, are identified as well as the associated security standards. The external identity is assessed to ensure their capabilities to properly meet the enterprise/sender's information security, business privacy and continuity standards, along with applicable industry standards. Based on the results of the assessment, remediation action may be required to address critical vulnerabilities or recommendations may be presented to a decision-making entity to grant authorization to electronically communicate the data in question to the external entity. In response to granting authorization, secure communication channels are allocated and established to allow for communication of the data. 1. An apparatus for granting authorization to electronically communicate secure data to an external entity , the apparatus comprising:a computing platform having a memory and at least one processor in communication with the memory; and an case submission application configured for, in response to a triggering event that requires electronic communication of secure data to an external entity, receiving user inputs that define first information associated with the external entity and second information associated with the secure data,', 'a validation application configured for managing a process for validating the external entity for electronically communicating the secure data to the external entity, wherein the process for validating is based at least in part on the first and second information, and', 'a data transmission application configured for, in response to validating the external entity and granting permission to communicate the secure data, manage a process for ...

Method for Selecting a Treatment for Non-Small Cell Lung Cancer Using Gene Expression Profiles

The present invention identifies and quantifies changes in gene expression associated with non-small cell lung cancer NSCLC by examining gene expression in tissue from normal lung and diseased lung. The present invention also identifies and quantifies expression profiles which serve as useful diagnostic markers as well as markers that are useful to monitor disease states, disease progression, drug toxicity, drug efficacy and drug metabolism. 1. A method for diagnosing bronchogenic carcinoma in an individual , the method comprising the steps of:a) providing a lung cell and/or tissue sample from the individual;b) determining levels of c-myc, E2F-1, and p21 gene products in the lung cell and/or tissue sample, wherein the levels are determine by microarray analysis, quantitative RT-PCR, or a combination of both,c) utilizing the levels of c-myc, E2F-1, and p21 gene products determined in step b), calculating a gene expression ratio of c-mycxE2F-1/p21; and{'sup': 3', '6, 'd) diagnosing bronchogenic carcinoma in an individual when the calculated gene expression ratio is greater than or equal to 7.20E(as molecules per 10β-actin molecules).'}2. The method of claim 1 , wherein the lung cell and/or tissue sample is collected by fine needle biopsy.3. The method of claim 1 , wherein the levels of mRNA for each of c-myc claim 1 , E2F-1 claim 1 , and p21 in the lung cell and/or tissue sample is determined by StaRT-PCR.4. The method of claim 1 , wherein the individual is diagnosed as having bronchogenic carcinoma when the calculated gene expression ratio is greater than or equal to 1.0E(as molecules per 10β-actin molecules).5. The method of claim 1 , wherein the individual is diagnosed as having bronchogenic carcinoma when the calculated gene expression ratio is 7.20E-3.6E(as molecules per 10β-actin molecules).6. The method of claim 1 , wherein the individual is diagnosed as having bronchogenic carcinoma when the calculated gene expression ratio is 1.0E-3.6E(as molecules per 10β- ...

SEALING LOUVERS FOR ROOF STRUCTURES

Louvered roof systems are provided with one or more louvers. Such louvers can be combined in an assembly that is movable between an open condition and a closed condition. In the closed condition, louvers in the assembly engage one another. In such engagement, a leg extending generally transversely from one louver may include a wing that extends generally transversely to the leg and that abuts a surface of an adjacent louver. Additionally or alternatively, in such engagement, a leg extending transversely from one louver may be received in a notch in an adjacent louver. 120-. (canceled)21. A louvered roof system comprising: (i) a first end;', '(ii) a second end opposite the first end;', '(iii) a leg having a proximal portion and a distal portion, the leg extending generally transverse to the second end and from the proximal portion to the distal portion;', '(iv) a top surface positioned on a top side of the louver and between outer edges of the louver, the top surface having a curvature at or adjacent the first end; and', '(v) a wing extending generally transverse to a longitudinal axis of the leg from the distal portion of the leg; wherein the wing is oriented such that, in the closed position, a first louver and a second louver of the plurality of louvers are engaged with one another such that the wing of the second louver abuts the first louver and extends away from the first end of the first louver and toward the second end of the first louver at an angle configured to mate against the curvature of the top surface at or adjacent the first end so as to obstruct passage of liquid between the first louver and the second louver., 'a louver of a plurality of louvers configured for movement between an open position and a closed position, each louver in the plurality of louvers comprising22. The louvered roof system of claim 21 , wherein the louver of the plurality of louvers comprises the second louver and the louvered roof system further comprises the first louver.23. ...

Weed removing and ejecting apparatus

A weed removal device having a handle and a frame through which a rod extends. The rod has a mechanical lock near one end that connects the rod mechanically to the frame, and a base portion near the opposite end. The base portion includes pins that extend into soil around the weed to grasp the weed, and a foot pedal on which the user rests his weight to drive portions of the device into the soil. A spring is compressed when the pins are driven into the soil and grasp the weed, and upon removal of the weed and a plug of soil the mechanical lock can release the spring to expand and thereby eject the weed and soil with force sufficient to propel the weed many feed into a receptacle.

Use of Unmanned Aerial Vehicles for NDT Inspections

An unmanned aerial vehicle (UAV), comprising one or more motors, one or more non-destructive testing data collectors, and an electro-magnet, may be used to inspect a structure to which it can magnetically attach by having the UAV approach the structure and activating the electro-magnet when the UAV is a predetermined distance to the structure to be inspected. Once maneuvered close enough to the structure to allow the electro-magnet to magnetically attach to the structure to be inspected, the UAV may be secured against the structure using the electro-magnet proximate an area to be inspected such that the non-destructive testing data collector is disposed proximate the area to be inspected. Data may then be collected using the non-destructive testing data collector.

METHOD AND APPARATUS FOR STORING MEMORY ATTRIBUTES

A system includes a processor and memory including one or more memory region groups, each including a plurality of distinct memory regions. In embodiments, each memory region of a particular memory region group has a same set of memory attributes and is associated with a same attribute group identifier (AGI). In response to an access request to a memory location of a memory region within the particular memory region group, the AGI may be used to identify the set of memory attributes to be applied when executing the access request. In response to a request to change one or more memory attributes of the particular memory region group, update of a single entry changes the memory attributes for all memory regions of the particular memory region group, without accessing individual metadata of each memory region. The update can be accomplished atomically and substantially simultaneously. 1. A system , comprising:a processor; anda system memory coupled to the processor, wherein the system memory comprises a plurality of regions corresponding to respective portions of a system memory address space for the processor;the processor comprising a memory management unit configured to perform memory operations to respective regions of the plurality of regions of the system memory for memory access instructions executed by the processor; assign a respective attribute group identifier (AGI) for each region of the plurality of regions of the system memory, wherein the plurality of regions comprise one or more memory region groups, wherein each region of a respective memory region group is assigned the same AGI; and', 'store a group attribute table comprising a respective entry for each different AGI of two or more different AGIs, wherein the entry for a particular AGI comprises one or more memory attributes that apply to each region of one of the one or more memory region groups to which the particular AGI is assigned;, 'wherein the processor is configured towherein, for a particular ...

ANTI-VASA ANTIBODIES, AND METHODS OF PRODUCTION AND USE THEREOF

Anti-VASA antibodies (mAbs), particularly humanized mAbs that specifically bind to VASA with high affinity, are disclosed. The amino acid sequences of the CDRs of the light chains and the heavy chains, as well as consensus sequences for these CDRs, of these anti-VASA mAbs are provided. The disclosure also provides nucleic acid molecules encoding the anti-VASA mAbs, expression vectors, host cells, methods for making the anti-VASA mAbs, and methods for expressing the anti-VASA mAbs. Finally, methods of using the anti-VASA mAbs to isolate and/or purify cells expressing VASA are disclosed. 1. A cell transformed with a nucleic acid molecule encoding a heavy chain or light chain of an antibody that specifically binds to a human VASA protein comprising an immunoglobulin heavy chain and an immunoglobulin light chain , (i) a CDR1 region comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 83-88;', '(ii) a CDR2 region comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 89-95; and', '(iii) a CDR3 region comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 96-104; and, 'a) wherein the variable region of said light chain comprises (i) a CDR1 region comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 105-112;', '(ii) a CDR2 region comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 113-121; and', '(iii) a CDR3 region comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 122-131., 'b) wherein the variable region of said heavy chain comprises2. The cell of claim 1 , wherein said nucleic acid molecule is selected from the group consisting of a cloning vector claim 1 , an expression vector claim 1 , a heterologous recombination vector claim 1 , and a viral integration vector.3. The cell of claim 1 , wherein said cell is a mammalian cell.4. The cell of claim 3 , wherein said cell is a rodent cell.5. ...

RHODOL-BASED THALLIUM SENSORS FOR HIGH-THROUGHPUT SCREENING OF POTASSIUM CHANNELS

Provided are novel rhodol-based compounds, the preparation method thereof, and use thereof in Tl flux assays. The disclosed compounds may be used as more red-shifted and less pH-sensitive variants of Thallos. 2. The compound of claim 1 , or a salt thereof claim 1 , wherein Z is O.3. The compound of claim 1 , or a salt thereof claim 1 , wherein p1 claim 1 , p2 claim 1 , p3 claim 1 , and p4 are each independently 0 or 1.4. The compound of claim 1 , or a salt thereof claim 1 , wherein p1 claim 1 , p2 claim 1 , p3 claim 1 , and p4 are 0.5. The compound of claim 1 , or a salt thereof claim 1 , wherein Ris Calkyl-CO—.6. The compound of claim 1 , or a salt thereof claim 1 , wherein Ris Calkyl.7. The compound of claim 1 , or a salt thereof claim 1 , wherein Rand Rare each independently hydrogen claim 1 , Calkyl claim 1 , Calkyl-CO— claim 1 , —Calkylene-Ccycloalkyl claim 1 , Ccycloalkyl claim 1 , —Calkylene-Caryl claim 1 , or Caryl claim 1 , wherein the Calkyl claim 1 , Calkyl-CO— claim 1 , —Calkylene-Ccycloalkyl claim 1 , Ccycloalkyl claim 1 , —Calkylene-Caryl claim 1 , and Caryl are optionally substituted with one or more substituents independently selected from the group consisting of halogen claim 1 , Chaloalkyl claim 1 , —CN claim 1 , Calkyl-O— claim 1 , Calkyl-CO—NH— claim 1 , and Calkyl-NH—CO—.8. The compound of claim 1 , or a salt thereof claim 1 , wherein Rand Rare each independently hydrogen claim 1 , Calkyl claim 1 , or cyclohexyl.9. The compound of claim 1 , or a salt thereof claim 1 , wherein Rand Rtogether with the N atom they are attached to form a 4 to 8-membered heterocycle claim 1 , wherein the heterocycle is optionally substituted one or more substituents independently selected from the group consisting of halogen claim 1 , Chaloalkyl claim 1 , —CN claim 1 , Calkyl-O— claim 1 , Calkyl-CO—NH— claim 1 , and Calkyl-NH—CO—.11. The compound of claim 1 , or a salt thereof claim 1 , wherein Rand Rare independently —C-alkylene-O—CO—R claim 1 , and each Ris ...

Sealing louvers for roof structures

Louvered roof systems are provided with one or more louvers. Such louvers can be combined in an assembly that is movable between an open condition and a closed condition. In the closed condition, louvers in the assembly engage one another. In such engagement, a leg extending generally transversely from one louver may include a wing that extends generally transversely to the leg and that abuts a surface of an adjacent louver. Additionally or alternatively, in such engagement, a leg extending transversely from one louver may be received in a notch in an adjacent louver. An end cap can include a downwardly extending flange that directs liquid flow from a louver's top surface and past its bottom surface to form droplets or streams to fall from a lower part of the flange and prevent travel of the liquid flow along the bottom surface of the louver.

THERAPEUTIC COMPOSITIONS, COMBINATIONS, AND METHODS OF USE

This invention relates to methods comprising administering a FAK inhibitor and an immunotherapeutic agent such as anti-PD-1 or anti-PD-L1; that are useful in the treatment of abnormal cell growth, such as cancer, in mammals, especially humans. 1. A method for treating a human subject suffering from cancer , comprising administering a FAK inhibitor in combination with an immunotherapeutic agent or procedure.2. The method of claim 1 , wherein the cancer is a solid tumor claim 1 , soft tissue tumor claim 1 , metastasis claim 1 , or non-solid cancer.3. The method of claim 2 , wherein the cancer is solid tumor.4. The method of claim 3 , wherein the solid tumor is a malignancy of an organ selected from the group consisting of lung claim 3 , breast claim 3 , lymphoid claim 3 , gastrointestinal and genitourinary tracts claim 3 , pharynx claim 3 , prostate claim 3 , and ovary.5. The method of claim 1 , wherein the cancer is a mesothelioma; neurofibromatosis; renal cancer; lung cancer claim 1 , non small cell lung cancer; liver cancer; thyroid cancer; ovarian; breast cancer; a nervous system tumor; schwannoma; meningioma; schwannomatosis; neuroma acoustic; adenoid cystic carcinoma; ependymoma; or ependymal tumors.67-. (canceled)8. The method of claim 1 , wherein the FAK inhibitor is administered orally.9. The method of claim 8 , wherein the FAK inhibitor is VS-4718 claim 8 , VS-5095 claim 8 , VS-6062 claim 8 , VS-6063 claim 8 , BI 853520 claim 8 , or GSK2256098.1014-. (canceled)15. The method of claim 8 , wherein the FAK inhibitor is administered at about 100 mg to about 2000 mg.16. The method of claim 8 , wherein the FAK inhibitor is VS-6063 and the FAK inhibitor is administered at about 200 mg to about 600 mg twice a day.17. (canceled)18. The method of claim 8 , wherein the FAK inhibitor is VS-4718 and the FAK inhibitor is administered at about 300 mg to about 500 mg once a day.19. The method of claim 18 , wherein the FAK inhibitor is VS-4718 and the FAK inhibitor is ...

POSITIVE ALLOSTERIC MODULATORS OF HUMAN MELANOCORTIN-4 RECEPTOR

Disclosed herein are positive allosteric modulators of melanocortin receptor and methods of using such modulators. 2. The compound of claim 1 , wherein Ris Ccycloalkyl.3. The compound of claim 1 , wherein Ris Calkyl or Calkoxyl.4. The compound of claim 1 , wherein Ris Ccycloheteroalkyl optionally substituted with Calkyl claim 1 , Ccycloalkyl claim 1 , or Cspirocycloalkyl.5. The compound of claim 1 , wherein X claim 1 , X claim 1 , and Xare all CH.6. The compound of claim 1 , wherein Xis N claim 1 , and Xand Xare CR claim 1 , Xis N and Xand Xare CR claim 1 , or Xis N and Xand Xare CR claim 1 , where each Rcan be independently selected from H claim 1 , Calkyl claim 1 , Calkoxyl claim 1 , Ccycloheteroalkyl claim 1 , carboxylic acid claim 1 , ester claim 1 , amino claim 1 , halide claim 1 , hydroxyl claim 1 , nitro claim 1 , Calkylsulfonyl claim 1 , Carylsulfonyl claim 1 , or thiol.7. The compound of claim 1 , wherein Xis CR claim 1 , where Ris chosen from Calkyl claim 1 , Calkoxyl claim 1 , Ccycloheteroalkyl claim 1 , carboxylic acid claim 1 , ester claim 1 , amino claim 1 , halide claim 1 , hydroxyl claim 1 , nitro claim 1 , Calkylsulfonyl claim 1 , Carylsulfonyl claim 1 , or thiol claim 1 , and Xand Xare CH.8. The compound of claim 1 , wherein Xis CR claim 1 , where Ris chosen from Calkyl claim 1 , Calkoxyl claim 1 , Ccycloheteroalkyl claim 1 , carboxylic acid claim 1 , ester claim 1 , amino claim 1 , halide claim 1 , hydroxyl claim 1 , nitro claim 1 , Calkylsulfonyl claim 1 , Carylsulfonyl claim 1 , or thiol claim 1 , and Xand Xcan be CH.10. The compound of claim 9 , wherein one Ris Br or Cl and the other R's are H.11. The compound of claim 9 , wherein Ris methyl claim 9 , ethyl claim 9 , methoxyl claim 9 , cyclopropyl claim 9 , or cyclobutyl.12. The compound of claim 9 , wherein one Ris H and the other Ris methyl or methylsulfonyl.13. The compound of claim 9 , wherein one Ris H and the other Ris morpholino claim 9 , any of which can be optionally substituted with ...

MICROLENS ARRAY FOR ENHANCED IMAGING OF MULTIREGION TARGETS

Systems and methods are provided for imaging a target as for example a multiwell plate. A plurality of regions of interest are selected on the target at a system control. The selected plurality of regions of interest are simultaneously imaged to provide an image with the plurality of regions of interest selectively magnified by a microlens array () and the regions that are not of interest are rejected by means of a mirrored aperture array, a mask, or selective illumination of the regions of interest of the target. 1. A system comprisinga target;an imaging system configured to simultaneously image a plurality of regions of interest to provide an image; anda microlens array, interposed between the target and the imaging system; anda region rejection component configured to prevent light reflected from non-ROI portions of the target from reaching the microlens array, the microlens array and the region rejection component being configured to selectively magnify the content of a plurality of regions of interest such that, within the image, at least one region that is not of interest is substantially replaced by the magnified content of the plurality of regions of interest.2. The system of claim 1 , wherein the target includes a multiwall plate having a plurality of wells claim 1 , separated by walls claim 1 , the plurality of regions of interest each including at least a portion of a well claim 1 , and the at least one region that is not of interest includes the walls separating the plurality of wells.3. The system of claim 1 , wherein the plurality of regions of interest is a proper subset of a set of regions of interest associated with the target.4. The system of claim 1 , further comprising a system control configured to select the plurality of regions of interest on the target.5. The system of claim 1 , the microlens array comprising a plurality of discrete microlens components claim 1 , a given microlens component comprising a doublet lens assembly.6. The system of ...

Substituted phenylamine carboxamide analogs as mglur5 negative allosteric modulators and methods of making and using the same

Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction

A method and apparatus for quantitative measurement of gene expression through multiplex competitive reverse transcriptase polymerase chain reaction amplification are disclosed. The method and apparatus are especially useful for analysis of small specimens of cells and tissues.

Subsea contactless connector system and method with extremely high data transfer rate

A pinless connector for subsea data communications comprises contactless connectivity data transmitter coupler, comprising one or more first solid state contactless connectivity data transmitters, and contactless connectivity data receiver coupler, comprising one or more first solid state contactless connectivity data receivers, which can allow for rapid collection and/or download data from subsea vehicles or sensors without having to plug in an external connector or physically remove the data recorder from the unit. Typically, these are operative at a low power level, e.g. less than or around 50 milliwatts, at an extremely high data transfer rate or around 5 GBits/second. The connectors may be incorporated into a subsea system comprising two subsea devices. A slip ring system may similarly comprise one or more first solid state contactless connectivity data transmitters and one or more first solid state contactless connectivity data receivers.

Automatic energy management and energy consumption reduction, especially in commercial and multi-building systems

Automatic energy management is provided, in even the most complex multi-building system. The necessity of a human operator for managing energy in a complex, multi-building system is reduced and even eliminated. Computer-based monitoring and computer-based recognition of adverse energy events (such as the approach of a new energy peak) is highly advantageous in energy management. Immediate automatic querying of energy users within a system of buildings for energy curtailment possibilities is provided. Such immediate, automatic querying may be answered by the energy users through artificial intelligence and/or neural network technology provided to or programmed into the energy users, and the queried energy users may respond in real-time. Those real-time computerized responses with energy curtailment possibilities may be received automatically by a data processing facility, and processed in real-time. Advantageously, the responses from queried energy users with energy curtailment possibilities may be automatically processed into a round-robin curtailment rotation which may be implemented by a computer-based control system. Thus, impact on occupants is minimized, and energy use and energy cost may be beneficially reduced in an intelligent, real-time manner. The invention also provides for early-recognition of impending adverse energy events, optimal response to a particular energy situation, real-time analysis of energy-related data, etc.

Self-vulcanizing synthetic polymers, manufacturing process and products obtained

Carrying out chemical reactions - using microwave energy to heat particles of contact solid

Diagnostics and network provisioning tool for bi-directional communication devices

Method and apparatus for performing remote bi-directional communication device diagnostics and network management. The method and apparatus includes retrieving IP addresses dynamically provided to each of a plurality of bi-directional communication devices respectively coupled to at least one termination system (TS). The retrieved IP addresses are associated with respective media access control (MAC) addresses, and an indicia of updated association of retrieved IP addresses and MAC addresses are stored in a local database. An IP address may be remotely accessed from the local database to perform diagnostics for a subscriber bi-directional communication device.

POSITIVE ALLOSMIC MODULATORS OF BENZAMIDE MGLURS AND METHODS FOR PREPARATION AND USE

Therapeutic compositions, combinations, and methods of use

This invention relates to methods comprising administering a FAK inhibitor and an immunotherapeutic agent such as anti-PD-1 or anti-PD-L1; that are useful in the treatment of abnormal cell growth, such as cancer, in mammals, especially humans.

Heterocyclic sulfone mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction.

Compuestos de sulfona heterocíclica que son útiles como potenciadores alostéricos/moduladores alostéricos positivos del receptor de glutamato metabotrópico del subtipo 4 (mGluR4); y métodos para utilizar los compuestos, por ejemplo, en el tratamiento de trastornos neurológicos y psiquiátricos u otros estados de enfermedad asociados con la disfunción del glutamato.

Methods and compositions for assessing nucleic acids and alleles

Benzisoxazoles and azabenzisoxazoles as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

Benzisoxazole and azabenzisoxazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.

Methods and systems for monitoring traffic received from and loading simulated traffic on broadband communication link

Methods and systems for loading and receiving traffic from a broadband communication link, such as an OC-3, link are disclosed. A system (100) for loading a broadband communication link includes a simulated traffic generator (113) for generating simulated traffic to be sent over the broadband communication link. Cascadable processing modules (102a-102n) receive and aggregate the simulated traffic to load a broadband communication link. The cascadable processing modules (102a-102n) can also receive and process data from a broadband communication link. Each cascadable processing module (102a-102n) filters and processes a portion of received traffic. A single platform can be configured to simultaneously load a broadband communication link and receive traffic from the broadband communication link.

Aryl and heteroaryl sulfones as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

In one aspect, the invention relates to sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.

Concrete pier foundation anchor bolt support and chamfer form

Embodiments of the Concrete Form include a form tube, chamfer disk, and one or more form cross-members. The form cross-members are comprised of a center pivot, two bolt guides, which are formed by the cross-members, and an optional clamp. The chamfer disk is a disk that sits atop of the form tube and forms side chamfers when placed upon the form tube when the concrete cures. The chamfer disk is a separate formed or molded piece that will sit on top of the tube form in order to form a chamfer in the concrete. The chanfer disk is a ring-shaped device with the chamfer formed in positive relief under the ring of the chamfer disk. The optional clamp can be used to hold any conduit, tube or any other item during the pour.

Method for wetting and dispersion of acrylic acid polymers

The disclosed technology concerns a method for wetting and dispersing a pulverulent polycarboxylic acid containing polymer in aqueous media without the need of a steric stabilizer and/or a wetting agent, said method comprises a) providing a pulverulent pre-neutralized carboxylic acid containing polymer or copolymer, wherein said polymer or copolymer is prepared from a monomer mixture comprising at least one olefinically unsaturated carboxylic acid group containing monomer, and wherein from about 1 to about 10 wt.% of said carboxylic acid group containing monomer(s) is neutralized; b) mixing said pulverulent pre-neutralized carboxylic acid containing polymer or copolymer in aqueous medium; and c) mixing a deswelling agent selected from an acid, a salt, and combinations thereof with said aqueous medium, and optionally d). adjusting the pH.

Mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and use thereof.

Crimping tool for fiber optic splice connector

Crimping apparatus for butt splicing two optical fibers in a connector requiring application of both radial and axial force comprises a frame, a workstation for holding the connector, a pair of radial die sets, and a pair of axial die sets. A disk journaled to the frame beneath the workstation has an integral ring-like member connected to respective die sets by four toggle links at ninety degree intervals. Rotating the disk causes the die sets to converge on a connector at the workstation.

Gear Pumps and Motors

1,177,922. Rotary positive-displacement pumps and motors. DOWTY HYDRAULIC UNITS Ltd. May 9, 1967 [Feb.17, 1966], No.6993/66. Heading F1F. In a rotary positive-displacement hydraulic pump, or motor, of the externally-meshing gear-type, pressure-loaded bearing-bushes 20-- 23 for shafts 16--19 carrying a pair of gears 14, 15 are lubricated by small quantities of working fluid at low-pressure entering a groove 48 in each bush through a radial slot 46, or 47, in the face of the bush adjacent the respective gear and an annular groove 38, 39, 40 or 41 in the corresponding shaft, the slot aforesaid being located adjacent a low-pressure port for said fluid. The working fluid enters each of the slots 46, 47 whenever one of the gear-tooth spaces is in register therewith. To ensure proper lubrication, a groove 50 in each bush is connected to the associated groove 48 by a further groove 53 and to another groove 55 by a chamber 36, 37, 42 or 43 and a channel 54, the groove 55 being situated such that suction is effected therein by the gear-teeth on each gear that are disengaging the gear-tooth spaces on the other gear. Pressureloading is effected by chambers 34, 35 connected to the high-pressure side of the gears and sealed by rings 30, 31 located eccentrically by projections 28, 29 to distribute axial thrust in accordance with the hydraulic gradient across the gears. The bushes 20, 22 and 21, 23 may be rendered integral with each other; and each of the grooves 53 may be replaced by at least one helical groove. There may be more than two gears.

Extremely high speed data transfer and communications

Floor box with improved activation ring

A plastic floor box assembly for use with electrical raceways installed in concrete floors, having a plastic box, an activation ring, a cover plate for retaining an electrical outlet, and an outlet cover securable to the cover plate. The activation ring is secured within the open top of the floor box by a plurality of retaining clips, having barbs extending outwardly and upwardly therefrom. The barbs allow easy insertion of the activation ring into the box, while preventing withdrawal. In a second embodiment designed for use in tile floors, a pair of support clips are also provided on the activation ring to prevent over-insertion of the ring into the box.

Anti-vasa antibodies and methods of production and use thereof

<p>SE DIVULGAN ANTICUERPOS ANTI-VASA (MABS), PARTICULARMENTE MABS HUMANIZADOS QUE SE UNEN ESPECÍFICAMENTE A VASA CON ALTA AFINIDAD. SE PROPORCIONAN LAS SECUENCIAS DE AMINOÁCIDOS DE LOS CDRS DE CADENAS LIGERAS Y CADENAS PESADAS, ASÍ COMO SECUENCIAS DE CONSENSO PARA ESTOS CDRS, DE ESTOS MABS ANTI-VASA. LA DIVULGACIÓN TAMBIÉN PROPORCIONA MOLÉCULAS DE ÁCIDO NUCLÉICO QUE CODIFICAN LOS MABS ANTI VASA, VECTORES DE EXPRESIÓN, CÉLULAS HUÉSPED, MÉTODOS PARA HACER LOS MABS ANTI-VASA Y MÉTODOS PARA EXPRESAR LOS MABS ANTI-VASA. FINALMENTE, SE DIVULGAN MÉTODOS PARA USAR LOS MABS ANTI-VASA PARA AISLAR Y/O PURIFICAR LAS CÉLULAS QUE EXPRESAN VASA.</p> <p> ANTI-VASE ANTIBODIES (MABS) ARE DISCLOSED, PARTICULARLY HUMANIZED MABS THAT SPECIFICALLY JOIN VESSEL WITH HIGH AFFINITY. THE AMINO ACID SEQUENCES OF THE CDRS OF LIGHT CHAINS AND HEAVY CHAINS ARE PROVIDED, AS WELL AS CONSENSUS SEQUENCES FOR THESE CDRS, OF THESE MABS ANTI-VASA. DISCLOSURE ALSO PROVIDES NUCLETIC ACID MOLECULES THAT CODIFY ANTI-VASE MABS, EXPRESSION VECTORS, GUEST CELLS, METHODS FOR MAKING ANTI-VASE MABS AND METHODS TO EXPRESS MABS. FINALLY, METHODS ARE DIVULATED TO USE ANTI-VASE MABS TO ISOLATE AND / OR PURIFY CELL EXPRESSING CELLS. </p>

Method and apparatus for using an IC to facilitate downloading content

A method and apparatus for using an integrated circuit card to facilitate downloading reusable content from a server into a terminal. Specifically, the method comprises the steps of verifying that an entitlement contained in the integrated circuit card is correct for receiving the reusable content from the server and downloading the reusable content from the server into a memory of the terminal. The apparatus comprises a terminal, coupled to a remote server and an integrated circuit card, coupled to the terminal via the interface circuit, for enabling the server to download the reusable content in the terminal. The terminal comprises a processor for processing the download of the content from the server, a memory for receiving the downloaded content and an integrated circuit card interface circuit.

o-benzyl nicotinamide analogues as positive allosteric modulators of mglur5

Use of unmanned aerial vehicles for ndt inspections

An unmanned aerial vehicle (UAV), comprising one or more motors, one or more non-destructive testing data collectors, and an electro-magnet, may be used to inspect a structure to which it can magnetically attach by having the UAV approach the structure and activating the electro-magnet when the UAV is a predetermined distance to the structure to be inspected. Once maneuvered close enough to the structure to allow the electro-magnet to magnetically attach to the structure to be inspected, the UAV may be secured against the structure using the electromagnet proximate an area to be inspected such that the non-destructive testing data collector is disposed proximate the area to be inspected. Data may then be collected using the nondestructive testing data collector.

Methods and compositions for assessing nucleic acids and alleles

The present invention is directed to methods and compositions for evaluating allelic variations with improved quality controls, methods of preparing such compositions, and applications employing such compositions and methods. In particular, the present invention provides methods and compositions for reducing false positives and/or false negatives in nucleic acid measurements.

Computer implemented method for marketing business services

This invention is directed to a computer implemented method for marketing business services. The invention more particularly relates to a computer implemented method for generating a document to market business services.

Anti-vasa antibodies, and methods of production and use thereof.

Anti-VASA antibodies (mAbs), particularly humanized mAbs that specifically bind to VASA with high affinity, are disclosed. The amino acid sequences of the CDRs of the light chains and the heavy chains, as well as consensus sequences for these CDRs, of these anti- VASA mAbs are provided. The disclosure also provides nucleic acid molecules encoding the anti-VASA mAbs, expression vectors, host cells, methods for making the anti-VASA mAbs, and methods for expressing the anti-VASA mAbs. Finally, methods of using the anti-VASA mAbs to isolate and/or purify cells expressing V ASA are disclosed.

Compositions and methods for treating cancer

This present invention composi-tions and methods of treating cancer and methods of accessing/monitoring the responsiveness of a cancer cell to a therapeutic compound.

O-benzyl nicotinamide analogs as mglur5 positive allosteric modulators

In one aspect, the invention relates to 0-benzyl nicotinamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions.

Releasable locking device

In a releasable locking device, which is useful at a beam-to-column connection in a storage rack, a housing having a lateral wall with two parallel slots has an end wall at an outer end and is open at the inner end, a locking pin having an internal portion movable within and along the lateral wall is movable between a retracted position and an extended position, toward which the locking pin is biased, and an outer sleeve is movable outside and along the lateral wall of the housing and is connected to the locking pin via a connecting pin extending through the locking pin, through the parallel slots, at each end to the outer sleeve. The outer sleeve has an external flange to facilitate pulling of the outer sleeve to move the locking pin toward the retracted position.

3.3.0 bicyclic glyt1 inhibitors and methods of making and using same

In one aspect, the invention relates to compounds which are useful as inhibitors of glycine type 1 transporter (GIyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GIyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Substituted heteroarylamine carboxamide analogs as mglur5 negative allosteric modulators and methods of making and using the same

Storage rack having roller track supported on horizontally extending front and back beams

A storage rack comprises horizontally extending front and back beams having upper surfaces, on which is supported a roller track comprising two side rails, a series of rollers journalled between and projecting above the side rails, and a series of tie rods extending between and bracing the side rails. The roller track is secured to the front and back beams by a front clip embracing an underside of the front beam, a J-bolt connected to the front clip and hooked over a front one of the tie rods, a back clip embracing an underside of the back beam, and a J-bolt connected to the back clip and hooked over a back one of the tie rods.

method and system for firing mode suppression control

MéTODO E SISTEMA PARA CONTROLE DE SUPRESSãO DO MODO DE ARTlFìClO. O presente pedido provê um método e sistema para o controle de esquemas de supressão do modo de artifício em conteúdo de mídia de tal modo que suporte ao modo de artifício pode ser reabilitado para o conteúdo recebido. Em uma modalidade da presente invenção, um método para controle de supressão de modo de artifício inclui examinar um sinal de conteúdo de mídia, recebido, para identificar porção(ões) porção de conteúdo de mídia com modo de artifício desabilitado. O método inclui ainda monitorar as porções identificadas do conteúdo de mídia com o modo de artifício desabilitado, para determinar qual porção(ões) de uma porção do conteúdo de mídia com modo de artifício desabilitado foi assistida. Em uma modalidade, a funcionalidade de modo de artifício é então restaurada para as porções do conteúdo de mídia com modo de artifício desabilitado que satisfaçam às condições prévias definidas no conteúdo de mídia à medida que ela está sendo assistida. METHOD AND SYSTEM FOR CONTROL OF SUPPRESSION OF THE ARTlFICLE MODE. The present application provides a method and system for controlling artifice suppression schemes in media content such that support for artifice mode can be rehabilitated for received content. In one embodiment of the present invention, a method for controlling firing mode suppression includes examining a received media content signal to identify portion (s) of media content with disabled firing mode. The method further includes monitoring the identified portions of the media content with the artifice disabled, to determine which portion (s) of a portion of the media content with the artifice disabled has been watched. In one embodiment, the artifice functionality is then restored to those portions of the media content with artifice disabled that satisfy the preconditions defined in the media content as it is being watched.

Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction

A method and apparatus for quantitative measurement of gene expression through multiplex competitive reverse transcriptase polymerase chain reaction amplification are disclosed. The method and apparatus are especially useful for analysis of small specimens of cells and tissues.

Automatic energy management and energy consumption reduction, especially in commercial and multi-building systems

Automatic energy management is provided, in even the most complex multi-building system. The necessity of a human operator for managing energy in a complex, multi-building system is reduced and even eliminated. Computer-based monitoring and computer-based recognition of adverse energy events (such as the approach of a new energy peak) is highly advantageous in energy management. Immediate automatic querying of energy users within a system of buildings for energy curtailment possibilities is provided. Such immediate, automatic querying may be answered by the energy users through artificial intelligence and/or neural network technology provided to or programmed into the energy users, and the queried energy users may respond in real-time. Those real-time computerized responses with energy curtailment possibilities may be received automatically by a data processing facility, and processed in real-time. Advantageously, the responses from queried energy users with energy curtailment possibilities may be automatically processed into a round-robin curtailment rotation which may be implemented by a computer-based control system. Thus, impact on occupants is minimized, and energy use and energy cost may be beneficially reduced in an intelligent, real-time manner. The invention also provides for early-recognition of impending adverse energy events, optimal response to a particular energy situation, real-time analysis of energy-related data, etc.

Method and apparatus for storing memory attributes

A system includes a processor and memory including one or more memory region groups, each including a plurality of distinct memory regions. In embodiments, each memory region of a particular memory region group has a same set of memory attributes and is associated with a same attribute group identifier (AGI). In response to an access request to a memory location of a memory region within the particular memory region group, the AGI may be used to identify the set of memory attributes to be applied when executing the access request. In response to a request to change one or more memory attributes of the particular memory region group, update of a single entry changes the memory attributes for all memory regions of the particular memory region group, without accessing individual metadata of each memory region. The update can be accomplished atomically and substantially simultaneously.