07-12-2017 дата публикации
Номер: US20170349571A1
Автор:
Baskaran Subramanian,
Bishop Michael J.,
Cone Roger D.,
Cox Helen,
Gimenez Luis Diaz,
Pantel Jaques,
Sebag Julien,
STEWART Eugene L.,
Tough Ian,
Weaver C. David,
Williams Savannah,
Wolfe Lawrence A.
Принадлежит:
Disclosed herein are positive allosteric modulators of melanocortin receptor and methods of using such modulators. 2. The compound of claim 1 , wherein Ris Ccycloalkyl.3. The compound of claim 1 , wherein Ris Calkyl or Calkoxyl.4. The compound of claim 1 , wherein Ris Ccycloheteroalkyl optionally substituted with Calkyl claim 1 , Ccycloalkyl claim 1 , or Cspirocycloalkyl.5. The compound of claim 1 , wherein X claim 1 , X claim 1 , and Xare all CH.6. The compound of claim 1 , wherein Xis N claim 1 , and Xand Xare CR claim 1 , Xis N and Xand Xare CR claim 1 , or Xis N and Xand Xare CR claim 1 , where each Rcan be independently selected from H claim 1 , Calkyl claim 1 , Calkoxyl claim 1 , Ccycloheteroalkyl claim 1 , carboxylic acid claim 1 , ester claim 1 , amino claim 1 , halide claim 1 , hydroxyl claim 1 , nitro claim 1 , Calkylsulfonyl claim 1 , Carylsulfonyl claim 1 , or thiol.7. The compound of claim 1 , wherein Xis CR claim 1 , where Ris chosen from Calkyl claim 1 , Calkoxyl claim 1 , Ccycloheteroalkyl claim 1 , carboxylic acid claim 1 , ester claim 1 , amino claim 1 , halide claim 1 , hydroxyl claim 1 , nitro claim 1 , Calkylsulfonyl claim 1 , Carylsulfonyl claim 1 , or thiol claim 1 , and Xand Xare CH.8. The compound of claim 1 , wherein Xis CR claim 1 , where Ris chosen from Calkyl claim 1 , Calkoxyl claim 1 , Ccycloheteroalkyl claim 1 , carboxylic acid claim 1 , ester claim 1 , amino claim 1 , halide claim 1 , hydroxyl claim 1 , nitro claim 1 , Calkylsulfonyl claim 1 , Carylsulfonyl claim 1 , or thiol claim 1 , and Xand Xcan be CH.10. The compound of claim 9 , wherein one Ris Br or Cl and the other R's are H.11. The compound of claim 9 , wherein Ris methyl claim 9 , ethyl claim 9 , methoxyl claim 9 , cyclopropyl claim 9 , or cyclobutyl.12. The compound of claim 9 , wherein one Ris H and the other Ris methyl or methylsulfonyl.13. The compound of claim 9 , wherein one Ris H and the other Ris morpholino claim 9 , any of which can be optionally substituted with ...
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