10-09-2015 дата публикации
Номер: US20150252038A1
Автор:
ANDREZ Jean-Christophe,
BICHLER Paul Robert,
Chen Chien-An,
Chowdhury Sultan,
DECKER Shannon Marie,
DEHNHARDT Christoph Martin,
FOCKEN Thilo,
GRIMWOOD Michael Edward,
HEMEON Ivan William,
Jia Qi,
LI JUN,
LIU Zhiguo,
Ortwine Daniel F.,
SAFINA Brian,
SHENG Tao,
Sun Shaoyi,
SUTHERLIN Daniel,
WHITE Andrew D.,
WILSON Michael Scott,
ZENOVA Alla Yurevna,
Zhu Jiuxiang
Принадлежит:
The invention provides compounds having the general formula I: 2. The compound of or a pharmaceutically acceptable salt thereof claim 1 , wherein:{'sup': 1', '1A', '1B', '1A', '1B', '1A', '1B', '1', 'R1a', 'R1b', 'R1a', 'R1a', 'R1a', 'R1a', 'R1b, 'sub': 1-8', '2-8', '1-8', '1-8', '3-8', '2-7', '1-8', '1-8', '1-4', '1-4', '2', '3', '3-6', '1-8', '1-8, 'b': '1', 'Ris Calkyl, Calkenyl, Chaloalkyl, Calkoxy, Ccarbocycle, C-linked Cheterocycle, or —NRR, wherein Rand Rare each independently selected from the group consisting of hydrogen, Calkyl, Calkoxy, and wherein Rand Rare optionally combined to form a 3 to 8 membered heterocyclic ring optionally comprising additional heteroatom selected from N, O and S; and wherein Ris optionally substituted with from 1 to 5 substituents selected from the group consisting of Calkyl, Chaloalkyl, F, Cl, Br, I, —OH, —CN, —NO, —NRR, —OR, —SR, —Si(R)and Ccarbocycle; wherein Rand Rare independently selected from the group consisting of hydrogen, Calkyl, Chaloalkyl;'}{'sup': 'N', 'sub': 1-4', '1-4, 'Ris hydrogen, Calkyl or Chaloalkyl;'}{'sup': '3', 'sub': 1-8', '1-8', '1-8, 'Ris selected from the group consisting of H, F, Cl, Br, I, —CN, Calkyl, Chaloalkyl and Calkoxy;'}{'sup': '5', 'sub': 1-8', '1-8', '1-8', '3-8', '2-7', '3-8', '2-7, 'Ris selected from the group consisting of F, Cl, Br, I, —CN, Calkyl, Chaloalkyl, Calkoxy, Ccycloalkyl and Cheterocycle, wherein said Ccycloalkyl and Cheterocycle is optionally substituted with 1-3 substituents seleted from F, Cl, Br and I;'}{'sub': 1-4', '2-4', '2-4', '1-4', '1-4, 'L is a linker selected from the group consisting of Calkylene, Calkenylene and Calkynylene, wherein L is optionally substituted with from 1 to 3 substituents selected from the group consisting of ═O, Calkyl, halo, and Chaloalkyl;'}the subscript m represents the integer 0 or 1;{'sup': 1', '2', 'X', 'x', '1', '2, 'sub': 2', '1-8', '1-8', '2', '1-8, 'Xand Xare each independently selected from the group consisting of absent, —O—, —S(O ...
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