14-05-2020 дата публикации
Номер: US20200149034A1
Автор:
Jin Li,
Barry A. Morgan,
Jinqiao Wan,
Dengfeng Dou,
Guansai Liu,
Yong Chang,
Qiuxia Chen,
Xing Wang,
Yanshan Xu,
Dongyan Hu,
Jian Liu,
Xuemin Cheng,
LI JIN,
MORGAN BARRY A,
WAN JINQIAO,
DOU DENGFENG,
LIU GUANSAI,
CHANG YONG,
CHEN QIUXIA,
WANG XING,
XU YANSHAN,
HU DONGYAN,
LIU JIAN,
CHENG XUEMIN,
Li, Jin,
Morgan, Barry A.,
Wan, Jinqiao,
Dou, Dengfeng,
Liu, Guansai,
Chang, Yong,
Chen, Qiuxia,
Wang, Xing,
Xu, Yanshan,
Hu, Dongyan,
Liu, Jian,
Cheng, Xuemin
Принадлежит:
Methods of producing compounds and combinatorial compound libraries, the compounds and libraries produced via the methods are provided, and methods of using the libraries to identify compounds having a desired property, such as a desired biological activity and the compounds identified using these methods are provided. 2. The compound of claim 1 , wherein X is a carbon atom claim 1 , a phosphorus atom claim 1 , or a polyatomic scaffold such as C1-12 alkyl claim 1 , C2-12 alkenyl claim 1 , C3-12 alkynyl claim 1 , C5-18 cycloalkyl claim 1 , C5-18 cycloalkenyl claim 1 , C3-18 heterocycloalkyl claim 1 , C3-18 heterocycloalkenyl claim 1 , C6-18 aryl or C3-18 heteroaryl group3. The compound of claim 1 , wherein the first and/or second functional groups are amine groups.5. The compound of claim 4 , wherein Y1 and/or Y2 at each occurrence is a different functional moiety.6. The compound of claim 4 , wherein Y1 and/or Y2 at each occurrence is the same functional moiety.7. The compound of claim 4 , wherein S1 and S2 each independently comprises an alkylene chain or an poly(ethylene glycol) chain claim 4 , wherein n is an integer from 1 to 20.8. The compound of claim 4 , wherein Z1 and Z2 each further comprise a PCR primer binding site sequence.9. The compound of claim 4 , wherein Y1 and Y2 each independently comprise a functional group claim 4 , selected from an amino group claim 4 , a hydroxyl group claim 4 , a carboxylic acid group claim 4 , a thiol group claim 4 , a halide claim 4 , an azido group claim 4 , an alkyne group claim 4 , or an alkene group.10. The compound of claim 4 , wherein L1 and L2 each are —OPO—(CHCHO)—PO— claim 4 , wherein n is an integer selected from 1 to 10.11. A compound library comprising at least about 10distinct compound species claim 1 , each species having the compound of claim 1 , wherein each species comprises at least two functional moieties that are operably linked to a double-stranded oligonucleotide which uniquely identifies the at least ...
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