Benzoyl hydrazone compounds with antineoplastic activity

The invention relates to an N'-5-substitutent aryl-2-furan-N-substitutent benzoyl hydyne compound (I) with a novel structure. The compound is produced by reaction of substituted aryl formohydrazide and 5-substitent aryl furan-2-formaldehyde. The compound is found through research to have anti-tumor activities in which people are interested, particularly the activities for resisting stomach cancer, human liver cancer and nasopharynx cancer.

Halogenated pyridine substituted disulphur heterocycle hexane compounds, preparation and uses thereof

The invention discloses halogenated pyridine substituted dithiacyclohexane compounds and a preparation method and application thereof, wherein a structural general formula of the compounds is shown in a formula (I). The preparation method of the compounds comprises the following steps: under the catalysis of an organic acid, a compound shown in a structural general formula of a formula (II) and a compound shown in a structural general formula of a formula (III) are subjected to condensation reaction to obtain a product. In the method, the mol ratio of the compound shown in the structural general formula of the formula (II) to the compound shown in the structural general formula of the formula (III) is between 1.0 to 1.0 and 1.5, and the using amount of formic acid accounts for 1 to 5 percent of that of the compound shown in the structural general formula of the formula (II); and the reaction temperature is between 0 and 80 DEG C, and the reaction time is between 0.5 and 10 hours. The preparation ...

Aryl hydrazide compounds with antineoplastic activity

The invention relates to novel N-tert-butyl-N-substituted aroyl group-N'-(5-substituted aryl-2-furanylcarbonyl) hydrazine compounds, which have a general formula (I), wherein Ar1 and Ar2 are as defined in an instruction; and the invention also relates to a preparation method thereof and application of the compounds used as an antitumor depressor.

Novel juvenile hormone synthesis inhibitor-phenylpropyl alcohol-glycerol-bright tripeptide amide analogue

The invention discloses a juvenile hormone synthesis inhibitor with novel structure, which is a phenylpropyl alcohol-glycerol-bright tripeptide amide analogue. The structure general formula of the compound provided by the invention is B: R-Leu-NH2, wherein the R stands for Phe-Gly-, Tyr-Gly-, PhCH2CH2CO-Gly-, PhCH=CHCO-Gly-, Ph(CH2)5CO-, Ph(CH2)4CO-, PhCH2NHCO(CH2)2CO-, PhCH2NHCO(CH2)3CO- or PhCH2NHCOCH2CO-. The compound with formula B simulates the chemical structure of a PHe-Gly-Leu-NH2 fragment of an A type AST and has simple structure and low synthesis cost. The compound has better inhibition activity for the juvenile hormone synthesis of black beetles. In the further application study, the compound obviously influences reproductive systems of female black beetles, inhibits the generation of black beetle eggs, conforms to the characteristic of an insect growth regulator and has better development and application prospects.

Preparation of halogenated pyridine substituted disulphur heterocycle hexane compounds

The invention discloses halogenated pyridine substituted dithiacyclohexane compounds and a preparation method and application thereof, wherein a structural general formula of the compounds is shown in a formula (I). The preparation method of the compounds comprises the following steps: under the catalysis of an organic acid, a compound shown in a structural general formula of a formula (II) and a compound shown in a structural general formula of a formula (III) are subjected to condensation reaction to obtain a product. In the method, the mol ratio of the compound shown in the structural general formula of the formula (II) to the compound shown in the structural general formula of the formula (III) is between 1.0 to 1.0 and 1.5, and the using amount of formic acid accounts for 1 to 5 percent of that of the compound shown in the structural general formula of the formula (II); and the reaction temperature is between 0 and 80 DEG C, and the reaction time is between 0.5 and 10 hours. The preparation ...

Substituted benzamido methyl formate compound as well as preparation method and uses thereof

具有抑制蚊幼虫生长活性的芳基酰肼类化合物

... 本发明涉及新颖的通式为(I)的N-取代芳基-N’-(5-取代芳基-2-呋喃甲酰基)肼类化合物，其中Ar#-[1]和Ar#-[2]如说明书中所定义，以及涉及其制备方法和该类化合物作为蚊幼虫的生长抑制剂的应用。∴ ...

Non-peptide juvenile hormone synthetic inhibitor

The invention discloses a non-peptide juvenile hormone synthetic inhibitor and belongs to the technical field of juvenile hormone synthetic inhibitors. A structural formula of an analogue is shown as a formula A. The non-peptide juvenile hormone synthetic inhibitor with a novel structure, simpleness, low cost and high activity of inhibiting juvenile hormone synthetic separation is obtained by substituting non-peptide micromolecule segments for amino acids in a core pentapeptide except for leucine. The compound of the formula A accords with the characteristics of an insect growth regulator andhas a good development application prospect.

Novel pentapeptide analogue and application thereof

The invention discloses a novel pentapeptide analogue and application thereof. The structure general formula of the compound provided by the invention is C: CR-Xaa-Phe-Gly-Leu-NH2, wherein the Xaa stands for the Gly, Asp, Asn, Ser or Ala; and the R stands for (substituted) benzoyl, (substituted) benzene acetyl, (substituted) hydrocinnamoyl, (substituted) butylbenzene, (substituted) benzene valeryl, (substituted) benzene hexanoyl, (substituted) benzenesulfonyl, 9-dimethoxycarbonyl, or benzyloxycarbonyl. Various organic acids with aromatic rings are introduced to replace Y/F in AST core pentapeptide (Y/FXFGLa) to prepare the pentapeptide analogue with simple structure and good inhibited juvenile hormone synthesis in-vitro activity, and the activity of partial compound with the formula C is superior to that of natural core pentapeptide. The further research indicates that partial compound with the formula C has better in-vivo activity, and the compound with the formula C conforms to the characteristic ...

12-sulfonyl amido-(15-methyl)-1,15-pentadecanolide, preparation method thereof and application as fungicides

The invention relates to a series of compounds of 12-sulfonyl amino-(15-methyl-)1, 15-pentadecalactone with a novel chemical structure and a general formula of CAUWL-2005-Z, a synthesis method and the preparations which can be used as agricultural fungicides. The invention takes 2-nitrocyclododecanone (1) as the raw materials, the 12-oxo-(15-methyl)-1,15-pentadecalactone (2) is obtained after the addition of acrolein or methyl vinyl ketone and the ring expansion, the 12-amino-(15-methyl)-1,15-pentadecalactone hydrochloride (3) is obtained by the reduction and ammonification of the latter, and the series of compounds with the general formular of CAUWL-2005-Z can be obtained by the sulfonylation reaction of (3). In the formula, R1 is hydrogen or methyl, R2 is benzyl, sulfur-containing heterocyclic radical, oxo naphthene base and the phenyl with 0 to 2 substituents, and the substituents can be F, Cl, Br, CH3, CH3O and NO2. The compounds with the general formula of CAUWL-2005-Z are dissolved ...

Insect allatostatin analogue modified by (substituted) phenylacrylic acid and application thereof in black beetle prevention

The invention discloses an insect allatostatin analogue modified by (substituted) phenylacrylic acid and application thereof in black beetle prevention. The structure general formula of the compound provided by the invention is A, wherein X stands for hydrogen, single or polysubstituted halogen, nitryl, methyl, ethide, methoxy or hydroxide radical. The compound with the formula A simulates the chemical structure of allatostatin core pentapeptide (Y/FXFGLa), has characteristics of simple structure and low synthesizing cost, and retains the in-vitro activity of natural allatostatin. The in-vitro activity of partial compounds is much higher than that of natural core pentapeptide, and some compounds have in-vivo activity which does not exist in the natural peptide. In the further application study, the compounds obviously influence reproductive systems of female black beetles, inhibit the generation of black beetle eggs, conform to the characteristic of an insect growth regulator and have better ...

1-thia-2- hydrocarbon imino-3,4-diaza-9- oxa (aza )-10-oxo spiro [4.15]-3- eicosanic, preparation method and usage as fungicide

The invention relates to a series of compounds of 1-thia-2-hydrocarbon imino-3, 4-diaza-9-oxo (aza)-10-oxo spiro (4.15)-3-eicosenyl with the general formula of CAUWL-2006-Lj and with a novel chemical structure, a synthesis method and the preparations as the agricultural fungicides. The invention takes 12-oxo-1, 15-pentadecalactone (lactam) as the raw materials, and the series of compounds with the general formula of CAUWL-2006-Lj can be prepared by condensation with the substituted thiosemicarbazide (1) in the appropriate solvent and the cyclization. In the formula, X is O or NH, R is the phenyl with 0 to 2 substituents, and the substituents are halogen, methyl and methoxy. The compounds with the general formula of CAUWL-2006-Lj are dissolved in the solvent, the surfactant is added, such as Nongru 0203B, 0208, GFC, OP-10, Tween-60 and so on, and the milk oil or the wettable powder can be prepared by even mixing by proportion. The compounds with the general formula of CAUWL-2006-Lj andthe ...

Triazolopyrimidine thioether compounds as new herbicide

A kind of 1,2,4-triazole (1,5-a) pyrimidine-2-thioether compouds used as herbicide is prepared by reaction of triazolopyrimidine thioether on substituted sulfamide (substituted aniline) in DMF, DMSO,or dioxhexacycle solvent. After dissolved in solvent, said compound is proportionally mixed with suractant such as GFC, OP-10, 0204, or Tween-80 to obtain emulsified oil or wettable powder, which hasinhibition action to common crabgrass herb, barnyard grass, rape and three-coloured amaranth, especially playing very good contact herbicide role to rape and three-coloured amaranth.

[E]-beta-farnesene analogue, preparing method and application of the same

[inverse]-beta- farnesene analogue, preparing method and application of the same

The invention discloses a preparing method of inverse-beta-fanihene analogue and application, which is characterized by the following: possessing compound with structural formula as formula 1; setting Y as O or S; setting Z as O, S or NCN; possessing good chemical activity for aphid. This compound possesses big molecular weight and good stability, which can get actual utility in agricultural production.

1-thia-2- hydrocarbon imino-3,4-diaza-9- oxa (aza )-10-oxo spiro [4.15]-3- eicosanic, preparation method and usage as fungicide

The invention relates to a series of compounds of 1-thia-2-hydrocarbon imino-3, 4-diaza-9-oxo (aza)-10-oxo spiro (4.15)-3-eicosenyl with the general formula of CAUWL-2006-Lj and with a novel chemical structure, a synthesis method and the preparations as the agricultural fungicides. The invention takes 12-oxo-1, 15-pentadecalactone (lactam) as the raw materials, and the series of compounds with the general formula of CAUWL-2006-Lj can be prepared by condensation with the substituted thiosemicarbazide (1) in the appropriate solvent and the cyclization. In the formula, X is O or NH, R is the phenyl with 0 to 2 substituents, and the substituents are halogen, methyl and methoxy. The compounds with the general formula of CAUWL-2006-Lj are dissolved in the solvent, the surfactant is added, such as Nongru 0203B, 0208, GFC, OP-10, Tween-60 and so on, and the milk oil or the wettable powder can be prepared by even mixing by proportion. The compounds with the general formula of CAUWL-2006-Lj and the ...

Practical bacteriocide 13-azl, 15-pentadecanolide borofluoride

Peptide analogue juvenile hormone synthesis inhibitor containing phenylpropyl alcohol-glycerol-bright tripeptide fragment

The invention discloses a novel peptide analogue juvenile hormone synthesis inhibitor which has a structure general formula D: R-Phe-Gly-Leu-NH2, wherein the R stands for (substituted) benzoyl, (substituted) benzene acetyl, (substituted) hydrocinnamoyl, (substituted) butylbenzene, (substituted) benzene valeryl, (substituted) benzene hexanoyl, (substituted) benzene acryloyl, diacid, fatty acid, hydrophobic amino acid, or the like. For the compound with the formula D, a tripeptide fragment Phe-Gly-Leu-NH2 of AST is used as a primer, and an N-end modification method is adopted to obtain a novel peptide analogue compound containing Phe-Gly-Leu-NH2 tripeptide which has simple structure. The activity of most compounds with the formula D is superior to that of the tripeptide fragment Phe-Gly-Leu-NH2, and the activity of an individual compound is equal to or superior than the activity of core pentapeptide of the natural AST. In the further application study, the partial compounds with the formula ...

Iron fillings motor sweeper

The utility model relates to an iron fillings motor sweeper, which comprises a carriage body, the bottom of automobile body is equipped with the wheel, is equipped with hand push frame and magnetism collection device on the automobile body, the both sides of automobile body are equipped with the brush of playing a minor role. Compared with the prior art, the utility model discloses iron fillings motor sweeper's beneficial effect does: (1 )The brush of playing a minor role can be swept the iron fillings of dead angle department to bottom of the car body, collects iron fillings through magnetism collection device, cleans effectually, (2 )Magnetism collection device's high, the appearance bits ability reinforce of degree of automation can improve and clean efficiency.

Aryl furfuran formyl hydrazone compounds with antineoplastic activity

The invention relates to an N'-5-substitutent aryl-2-furan formoxyl-N-substitutent benzoyl hydyne compound (II) with a novel structure. The compound is produced by reaction of substituted aryl formaldehyde and 5-substitutent aryl-2-furan formohydrazide. The compound is found through research to have anti-tumor activities in which people are interested, particularly the activities for resisting stomach cancer, human liver cancer and nasopharynx cancer.

2-keto naphthene sulfamide, its preparing method and use as germicide

Substituted benzamido methyl formate compound as well as preparation method and uses thereof

Aryl hydrazide compound with activity of inhibiting growth of mosqito larva

The present invention relates to one kind of N-substituted aryl-N'-(5-substituted aryl-2-furylformyl) hydrazine compounds, its preparation and application as mosquito larva inhibitor.