06-11-2014 дата публикации
Номер: WO2014178468A1
Автор:
KIM, Hyeon Jin,
HONG, Seong Tshool,
CHUNG, Hea Jong,
JOO, Min Kyu,
CHO, Hea Guk,
HONG, Jinny
Принадлежит:
The present invention relates to anticancer nanoparticles with improved target specificity for cancer tissue, and a preparation method therefor, and more specifically, to anticancer nanoparticles with amplified target specificity, wherein an anticancer drug, serum albumin as a nanoparticle base material, and a porphyrin-based compound as a target specific material are noncovalently bonded, and a preparation method therefor. The anticancer drug, the serum albumin as a base material, and the porphyrin as a target specific material are noncovalently bonded in the anticancer nanoparticles with amplified target specificity according to the present invention, and thus it is possible to prevent a toxic side effect, a decrease in efficacy of the anticancer drug and a decrease in target specificity, which frequently appear in anticancer nanoparticles, the nanoparticles are further stabilized, and cancer target specificity is amplified during electromagnetic wave irradiation since an active oxygen-forming ...
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