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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 44. Отображено 44.
26-06-2017 дата публикации

COMPOSITION COMPRISING COMPOUNDS ISOLATED FROM NANDINA DOMESTICA FOR PREVENTING OR TREATING VASCULAR INFLAMMATION DISEASES

Номер: KR1020170071770A
Принадлежит:

The present invention relates to a composition comprising an extract of Nandina domestica or compounds isolated from Nandina domestica for preventing or treating vascular inflammation diseases. The extract of Nandina domestica or compounds isolated from Nandina domestica inhibit vascular endothelial functional disorder associated with vascular inflammation, thereby being expected to treat vascular inflammation diseases such as hypertension, ischemic heart diseases, coronary artery diseases, angina, myocardial infarction, arteriosclerosis, cardiovascular diseases, stroke and arrhythmia. COPYRIGHT KIPO 2017 ...

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04-10-2018 дата публикации

COMPOSITION COMPRISING COMPOUND ISOLATED FROM TENEBRIO MOLITOR LARVA FOR ANTITHROMBOSIS

Номер: KR1020180108094A
Принадлежит:

The present invention relates to a composition comprising at least one kind of compounds selected from a group consisting of cyclo (L-proline-L-tyrosine) (compound 1), N-acetyl tyramine (compound 2) and hydroxcitrosol (compound 3) for antithrombosis, antiplatelet or anticoagulation. The compound inhibits a blood coagulation pathway through the inhibition of FXa in HUVEC, inhibits platelet aggregation in vitro and in vivo, and thus can be usefully used as a pharmaceutical composition or health functional food for treatment or prevention of vascular diseases associated with the blood coagulation. COPYRIGHT KIPO 2018 ...

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15-10-2018 дата публикации

COMPOSITION FOR REDUCING SKIN WRINKLES OR FOR SKIN MOISTURIZING COMPRISING PROTAETIA BREVITARSIS EXTRACT OR COMPOUND ISOLATED THEREFROM AS EFFECTIVE COMPONENT

Номер: KR101907850B1

The present invention relates to a composition for reducing skin wrinkles or for skin moisturizing comprising a Protaetia brevitarsis extract or a compound isolated therefrom as an effective component, and specifically, the Protaetia brevitarsis extract and compounds represented by chemical formulas 1 to 5 have little cytotoxicity, the expression of MMP-1 promoted by ultraviolet irradiation is remarkably suppressed, and the content of hyaluronic acid which can enhance skin moisturization is enhanced. Accordingly, the composition of the present invention can be usefully used as a cosmetic composition for reducing skin wrinkles or for skin moisturizing, a pharmaceutical composition for preventing or treating skin wrinkles, or health functional food composition for reducing skin wrinkles or anti-aging. COPYRIGHT KIPO 2018 ...

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05-09-2018 дата публикации

COSMETIC COMPOSITION FOR REDUCING SKIN WRINKLES COMPRISING OXYA CHINENSIS SINUOSA EXTRACT OR COMPOUND ISOLATED FROM EXTRACT AS EFFECTIVE COMPONENT

Номер: KR1020180099563A
Принадлежит:

The present invention relates to a cosmetic composition for preventing or reducing skin wrinkles comprising an Oxya chinensis sinuosa extract containing: a compound of chemical formula 1 or acceptable salt thereof; a compound of chemical formula 2 or acceptable salt thereof; a compound of chemical formula 3 or acceptable salt thereof; or at least one compound selected from compounds of chemical formula 1 to 3, as effective components, wherein the cosmetic composition inhibits cell damage due to ultraviolet irradiation, and remarkably inhibits the expression of MMP-1, thereby being used as cosmetics for reducing the skin wrinkles. COPYRIGHT KIPO 2018 (AA) Expression of MMP-1 (ng/ml) (BB) Concentration of a compound derived from an Oxya chinensis sinuosa extract (CC) Compound A (DD) Compound B (EE) Compound C ...

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13-12-2017 дата публикации

남천으로부터 분리한 화합물을 포함하는 혈관 염증 질환 예방 또는 치료용 조성물

Номер: KR0101808816B1
Автор: 나민균, 이정인, 배종섭

... 본 발명은 남천 추출물 또는 이로부터 분리한 화합물을 포함하는 혈관 염증 질환의 예방 또는 치료용 조성물에 관한 것으로, 남천 추출물 또는 이로부터 분리한 화합물은 혈관 염증과 관련되어 있는 혈관 내피의 기능장애를 억제함으로써 고혈압, 허혈성 심장질환, 관상동맥질환, 협심증, 심근경색, 동맥경화증, 뇌혈관질환, 뇌졸중, 부정맥과 같은 심혈관질환 및 패혈증 등과 같은 혈관 염증 질환을 치료할 수 있을 것으로 기대된다.

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15-02-2016 дата публикации

COMPOSITION COMPRISING HYPEROSIDE FOR PREVENTING OR TREATING SEPSIS

Номер: KR1020160015742A
Принадлежит:

The present invention relates to a composition comprising hyperoside. The composition has excellent effects in inhibiting the expression of high mobility group box 1 (HMGB1) in vascular endothelial cells, and can be easily used as a pharmaceutical composition for preventing or treating sepsis or as a health functional food for preventing or alleviating sepsis. COPYRIGHT KIPO 2016 ...

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10-05-2018 дата публикации

AIR CONDITIONING APPARATUS FOR VEHICLE

Номер: KR1020180047052A
Принадлежит:

Disclosed is an air conditioning apparatus for a vehicle, which has an evaporator pipe for maximizing sound absorption and sound insulation effects without an increase in manufacturing costs. The air conditioning apparatus for a vehicle comprises: an evaporator, in which a refrigerant is flowing, transferring heat between air passing through the same and the refrigerant; and the evaporator pipe having an inlet pipe for allowing the refrigerant to flow into a core side of the evaporator and an outlet pipe for discharging the refrigerant. Moreover, a first coating layer made of materials different from the material of the evaporator pipe is formed on at least one of an inner surface and an outer surface of the evaporator pipe. COPYRIGHT KIPO 2018 (AA) Refrigerant ...

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11-10-2018 дата публикации

COMPOSITION, CONTAINING PROTAETIA BREVITARSIS EXTRACT OR COMPOUND ISOLATED THEREFROM AS ACTIVE INGREDIENT, FOR SKIN MOISTURIZATION OR SKIN WRINKLE RELIEF

Номер: WO2018186724A1
Принадлежит:

The present invention relates to a composition, containing a Protaetia brevitarsis extract or a compound isolated therefrom as active ingredient, for skin moisturization or skin wrinkle relief. More specifically, the Protaetia brevitarsis extract and compounds of chemical formulas 1-5 have little cytotoxicity, significantly suppress MMP-1 and MMP-9 expressions promoted by ultraviolet irradiation, also reduce the skin thickness increased by ultraviolet irradiation, increase the content of hyaluronic acid capable of promoting skin moisturization, reduce the transdermal water loss, and increase the skin moisture content. Therefore, the composition of the present invention can be used as a health functional food composition for skin moisturization or wrinkle relief, or as a pharmaceutical composition for skin wrinkle relief or anti-aging action.

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05-09-2018 дата публикации

COMPOSITION FOR PREVENTING, AMELIORATING, OR TREATING SKIN WRINKLES CONTAINING OXYA CHINENSIS SINUOSA EXTRACT OR COMPOUND ISOLATED THEREFROM AS ACTIVE INGREDIENT

Номер: KR1020180099569A
Принадлежит:

The present invention relates to a composition for preventing, ameliorating, or treating skin wrinkles containing an Oxya chinensis sinuosa extract as an active ingredient, comprising a compound represented by chemical formula 1 or an acceptable salt thereof; a compound represented by chemical formula 2 or an acceptable salt thereof; a compound represented by chemical formula 3 or an acceptable salt thereof; or at least one compound selected among compounds represented by chemical formula 1 to 3. The composition of the present invention prevents cell damage caused by ultraviolet irradiation, and significantly suppresses expression of matrix metalloproteinase-1 (MMP-1), thereby being applied as drugs or health functional foods for preventing, ameliorating, or treating skin wrinkles. COPYRIGHT KIPO 2018 ...

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14-12-2017 дата публикации

왕지네 유래 신규 화합물 및 이의 항혈전 용도

Номер: KR0101808196B1

... 본 발명은 왕지네(Scolopendrasubspinipes)로부터 분리한 화학식 1, 화학식 2 및 화학식 3으로 표시되는 화합물, 또는 이들의 약학적으로 허용가능한 염을 유효성분으로 함유하는 항혈전, 항혈소판 및 항응고용 약학적 조성물에 관한 것으로서, 보다 상세하게는 화학식 1, 화학식 2 및 화학식 3으로 표시되는 화합물은 인간 제대정맥혈관내피세포(human umbilical vein endothelial cells, HUVECs)에서 활성화 부분 트롬보플라스틴 시간(activated partial thromboplastin time, aPTT) 및 프로트롬빈 시간(prothrombin time, PT)을 연장하고 트롬빈 및 활성화된 인자 X(activated factor X, FXa)를 억제하며, 트롬빈에 의해 촉매된 피브린 중합 및 혈소판 응집을 억제하고, 폐색전증 모델 및 동맥 혈전증 모델에서 항혈전 효과를 증진시키며, 단백질 키나아제 C(protein kinase C, PKC) 활성 및 칼슘 동원을 방지하고, 마우스에서 항응고 효과를 야기하며, 조직 플라스미노겐 활성화제(tissue plasminogen activator, t-PA)에 대한 플라스미노겐 활성화제 억제제-1(plasminogen activator inhibitor-1, PAI-1)의 비율을 감소시킴으로써, 항혈전제, 항혈소판제 및 항응고제의 유효성분으로 유용하게 사용될 수 있다.

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13-12-2016 дата публикации

COMPOSITION COMPRISING QUINIC ACID DERIVATIVES FOR PREVENTING OR TREATING SEPSIS

Номер: KR1020160142723A
Принадлежит:

The present invention relates to a composition comprising quinic acid derivatives for preventing or treating sepsis. The composition inhibits expression of high mobility group box 1 (HMGB1), and inhibits a death rate according to cecal ligation and puncture (CLP) operation, thereby being used as a composition for preventing or treating sepsis or a health functional food for preventing or alleviating sepsis. COPYRIGHT KIPO 2016 (AA) Compound 1 (BB) Compound 2 (CC) Compound 3 (DD) Compound 4 (EE) Compound 5 (FF) Compound 6 ...

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25-04-2023 дата публикации

튤립나무(Liriodendron tulipifera) 추출물 또는 이로부터 분리한 Alkamide를 포함하는 항염증 조성물

Номер: KR102525843B1
Принадлежит: 충남대학교산학협력단

... 본 발명은 튤립나무(Liriodendron tulipifera) 추출물 또는 이로부터 분리한 화합물을 포함하는 항염증 조성물에 관한 것으로, 구체적으로는 NO(Nitric Oxide) 형성을 억제하고 iNOS, COX-2 및 IL-1β의 발현을 억제하며 IRAK1 분해에 영향을 주지 않으면서 IKK 인산화를 억제하여 NF-κB 신호경로를 차단함으로써 항염활성을 갖는 것을 확인하였으며, 이를 이용하여 염증 예방 또는 치료에 기여할 것으로 기대된다.

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28-08-2015 дата публикации

COMPOSITION CONTAINING EXTRACT OF RHODODENDRON BRACHYCARPUM OR MEGASTIGMANE GLUCOSIDES ISOLATED THEREFROM FOR PREVENTING OR TREATING SEPSIS

Номер: KR1020150098599A
Принадлежит:

The present invention relates to a composition containing an extract of Rhododendron brachycapum or megastigmane glucosides isolated therefrom for preventing or treating sepsis. The composition has an excellent effect of controlling expression of high mobility group box 1 (HMGB1) in vascular endothelial cells, thereby being easily used as a medical composition for preventing or treating sepsis or a health functional food for preventing or alleviating sepsis. COPYRIGHT KIPO 2015 ...

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13-03-2025 дата публикации

테트라셀미스 츄이로부터 분리한 신규 화합물 및 이의 용도

Номер: KR102780726B1

... 본 발명은 테트라셀미스 츄이로부터 분리한 신규 화합물을 포함하는 염증성 질환 또는 안구건조증의 예방, 개선 또는 치료용 조성물에 관한 것으로, 상기 테트라셀미스 츄이로부터 분리한 신규 화합물이 LPS로 유도한 인터루킨-6의 생성량을 감소시키는 효과가 있고, 안구건조증 동물모델에서, 눈물량 감소, 각막표면의 손상 완화, 각막 두께의 증가 및 안구건조증 관련 인자의 유전자 발현량 감소 뿐만 아니라, 각막 조직에서의 염증 관련 마커의 단백질 발현량을 감소시키는 효과가 있으며, 건선 동물모델에서 유발된 피부염을 개선하는 효과가 있으므로, 본 발명의 조성물을 염증성 질환 또는 안구건조증의 예방, 개선 또는 치료용 의약품, 건강기능식품, 의약외품, 또는 사료첨제로 유용하게 이용할 수 있다.

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05-07-2018 дата публикации

COSMETIC COMPOSITION FOR IMPROVING SKIN WRINKLE OR MOISTURIZING SKIN, CONTAINING PROTAETIA BREVITARSIS EXTRACT OR COMPOUND DIVIDED FROM PROTAETIA BREVITARSIS EXTRACT AS EFFECTIVE COMPONENT

Номер: KR101874467B1

The present invention relates to a composition for improving skin wrinkles or moisturizing skin, containing a Protaetia brevitarsis extract or a compound divided from the Protaetia brevitarsis extract as an effective component. Specifically, the composition is to improve the content of hyaluronic acid capable of improving skin moisture and remarkably suppressing a manifestation of MMP-1 increased by radiation of ultraviolet rays. The composition of chemical formulas 1-5 and the Protaetia brevitarsis extract rarely have cytotoxicity. Therefore, according to the present invention, the composition can be used as a cosmetic composition for improving skin wrinkles, a chemical composition for preventing or curing skin wrinkles, or an anti-aging health functional food composition for improving skin wrinkles. COPYRIGHT KIPO 2018 (AA) Concentration of Protaetia brevitarsis extract ( μg / ml) (BB) Compound 1 (CC) Compound 2 (DD) Compound 3 (EE) Compound 4 (FF) Compound 5 (GG) Concentration of compound ...

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15-12-2016 дата публикации

EXPANSION VALVE

Номер: KR1020160143941A
Принадлежит:

Disclosed is an expansion valve to minimize energy loss by spraying refrigerant at an angle which is the closest with respect to a refrigerant progress direction. The expansion valve comprises: a valve body in which a first flow path and a second flow path for the inflow and outflow of refrigerant are formed to be spaced from each other in a longitudinal direction; a rod of which an end portion passes through the first flow path to extend in the second flow path in a longitudinal direction of the valve body; a head provided at one side of a longitudinal direction of the valve body, and moving the rod to reciprocate in a longitudinal direction in accordance with a temperature of the refrigerant; an elastic member provided in the second flow path for an elastic force to be applied to the rod; and an opening and closing unit provided between the end portion of the rod and the elastic member to open and close an orifice hole of the second flow path. Moreover, an inclination portion is formed ...

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15-01-2016 дата публикации

AIR CONDITIONER FOR VEHICLE

Номер: KR0101585892B1
Автор: 나민균
Принадлежит: 한온시스템 주식회사

... 본 발명은 차량용 공조장치에 관한 것으로, 열교환기 및 상기 열교환기가 내장 설치됨과 아울러 열교환기의 파이프를 외부로 인출시키도록 형성된 공조케이스를 포함하여 이루어진 차량용 공조장치에 있어서, 상기 공조케이스의 일측에는 상기 열교환기의 파이프 인출위치를 다수 개 형성하여 그 중 하나의 인출위치로 파이프가 선택적으로 인출되도록 이루어진 인출공간이 형성되며, 상기 인출공간 둘레에는 파이프가 선택적으로 안착 고정되는 제1, 2 고정홈이 서로 일정 간격 이격되게 형성되고, 상기 인출공간의 제1, 2 고정홈 사이 영역에 장착되되, 일측은 제1, 2 고정홈 중 파이프가 인출되지 않는 고정홈과 결합되어 고정홈을 차폐함과 아울러 타측은 파이프가 인출되는 고정홈에 대응되어 인출되는 파이프 둘레를 감싸도록 형성된 고정부재를 더 구비한 차량용 공조장치를 제공한다. 본 발명에 따르면, RHD 혹은 LHD와 같은 차량의 사양에 따라 증발기 인출 파이프의 인출 위치가 변하더라도 가변가능한 고정부재를 통해 이를 지지고정함으로써 HVAC의 공조케이스를 공용화시킬 수 있어 설계 및 금형비용을 줄일 수 있고, 조립작업이 용이한 효과를 얻을 수 있다.

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22-09-2017 дата публикации

함초로부터 분리된 화합물을 함유하는 혈관 염증 또는 패혈증의 예방 또는 치료용 조성물

Номер: KR0101781083B1
Автор: 나민균, 배종섭

... 본 발명은 함초 유래의 화합물을 함유하는 혈관 염증 또는 패혈증의 예방 또는 치료용 조성물에 관한 것으로서, 상기 화합물은 플라바논 또는 크로몬 유도체(flavanones or chromones derivatives)로서, 상기 화합물은 HMGB1(high mobility group box 1)의 발현을 억제하고, CLP 수술법(cecal ligation and puncture operation)에 따른 마우스의 사망률을 억제하는 효과가 우수하여 혈관 염증 또는 패혈증의 예방 또는 치료용 의약 조성물이나 혈관 염증 또는 패혈증의 예방 또는 개선용 건강기능식품으로 용이하게 이용가능하다.

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18-07-2017 дата публикации

ANTITHROMBOTIC COMPOSITION CONTAINING COMPOUND ISOLATED FROM PROTAETIA BREVITARSIS SEULENSIS LARVA

Номер: KR101758718B1

The present invention relates to an antithrombotic, antiplatelet, or anticoagulant composition containing one or more compounds selected from 5-hydroxyindolin-2-one (compound 1) isolated from Protaetia brevitarsis seulensis and 1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (compound 2). The compound suppresses an exogenic and endogenetic blood coagulation pathway by suppressing FXa and thrombin production in HUVEC, suppresses secretion of PAI-1 induced by TNF-α, suppresses platelet coagulation in vivo and in vitro, and specifically prevents protein kinase C and calcium kinetics. Thus, the compound can be useful as a pharmaceutical composition or health functional food for treating or preventing blood vessel diseases related to blood coagulation. COPYRIGHT KIPO 2017 ...

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05-07-2017 дата публикации

퀴닉산 유도체를 함유하는 패혈증의 예방 또는 치료용 조성물

Номер: KR0101754142B1
Автор: 나민균, 배종섭

... 본 발명은 퀴닉산 유도체(Quinic acid derivatives)를 함유하는 패혈증의 예방 또는 치료용 조성물에 관한 것으로서, 상기 조성물은 HMGB1(high mobility group box 1)의 발현을 억제하고, CLP 수술법(cecal ligation and puncture operation)에 따른 사망률을 억제하는 효과가 우수하여, 패혈증의 예방 또는 치료용 조성물이나 패혈증의 예방 또는 개선용 건강기능식품으로 용이하게 이용가능하다.

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17-01-2018 дата публикации

ANTITHROMBOTIC COMPOSITION COMPRISING COMPOUND ISOLATED FROM PROTAETIA BREVITARSIS SEULENSIS LARVA

Номер: KR1020180006297A
Принадлежит:

The present invention relates to a composition for antithrombosis, antiplatelet or anticoagulation comprising a compound selected from the group consisting of 5-hydroxyindolin-2-one (compound 1) and 1-methyl-1, 2, 3, 4-tetrahydro-β-carboline-3-carboxylic acid (compound 2) isolated from Protaetia brevitarsis seulensis. The compound inhibits an exogenous and endogenous blood coagulation pathway through inhibition of FXa and thrombin production in HUVEC, suppresses the secretion of PAI-1 induced by TNF-α, inhibits platelet aggregation in vitro, and specifically prevents protein kinase C and calcium mobilization, thereby being useful as a pharmaceutical composition or a health functional food for the treatment or prevention of vascular diseases associated with such blood coagulation. COPYRIGHT KIPO 2018 ...

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07-09-2018 дата публикации

COMPOSITION, CONTAINING OXYA CHINENSIS SINUOSA EXTRACT OR COMPOUND ISOLATED THEREFROM AS ACTIVE INGREDIENT, FOR PREVENTION, RELIEF, OR TREATMENT OF SKIN WRINKLES

Номер: WO2018160021A1
Принадлежит:

The present invention relates to a composition for prevention, relief, or treatment of skin wrinkles, the composition containing, as an active ingredient, an Oxya chinensis sinuosa extract comprising a compound of chemical formula 1 or an acceptable salt thereof, a compound of chemical formula 2 or an acceptable salt thereof, a compound of chemical formula 3 or an acceptable salt thereof, or at least one compound selected from the compounds of chemical formulas 1 to 3. The composition suppresses cell damage caused by ultraviolet irradiation and remarkably inhibits MMP-1 expression, and thus can be utilized as a health functional food or medicinal product for prevention, relief, or treatment of skin wrinkles.

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19-06-2018 дата публикации

AIR CONDITIONING APPARATUS FOR VEHICLE

Номер: KR1020180066352A
Принадлежит:

The present invention relates to an air conditioning apparatus for a vehicle, and the objective of the present invention is to insulate vibrational noise of an engine and a compressor transferred to an air conditioning case through a refrigerant pipe system so as to prevent oscillation of the air conditioning case caused by transfer of the vibrational noise and prevent amplification of the vibrational noise thereby, and reduce the vibration therethrough so as to improve pleasantness and driving environment inside a passenger compartment. To achieve this, the air conditioning apparatus comprises: the air conditioning case; an evaporator mounted in an evaporator mounting part inside the air conditioning case; and a refrigerant pipe to supply and discharge the refrigerant to and from the evaporator. The refrigerant pipe is received inside the air conditioning case through a pipe hole formed on the air conditioning case to be connected to the evaporator. In order to attenuate the vibrational ...

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06-04-2016 дата публикации

Blower Unit for Car Air Conditioning System

Номер: KR0101609673B1
Автор: 나민균
Принадлежит: 한온시스템 주식회사

... 개시발명은, 내기 유입구(101) 및 외기 유입구(102)를 갖는 에어 인테이크 케이스(100)와, 상기 에어 인테이크 케이스(100)의 아래쪽에 형성되며 내부에 송풍팬(122)이 설치되는 스크롤 케이스(120)와, 상기 에어 인테이크 케이스(100)로부터 상기 스크롤 케이스(120)로 공기의 흡입을 안내하기 위해 상기 스크롤 케이스(120)의 상부에 형성된 벨 마우스(124), 및 상기 에어 인테이크 케이스(100)의 일측면에 형성된 필터 삽입구(104)를 통해 삽입 설치되는 에어필터(130)를 포함하는 자동차용 공조장치의 송풍유닛에 있어서, 상기 에어 인테이크 케이스(100)의 내측면중 상기 벨 마우스(124)와 이격된 위치에 상기 에어필터(130)가 안착되는 안착턱(103)이 형성되며, 상기 에어필터(130)의 저면 가장자리에는 상기 안착턱(103)에 안착되며 자체에 탄성력을 갖고 있어, 상기 에어필터(130)의 설치시 상기 에어필터(130)의 위치를 상승시키는 브릿지(131)가 형성된다. 따라서, 내외기 모드 선택시에 에어 인테이크 케이스 내로 유입되는 공기가 에어필터의 일부분으로만 통과하는일이 없이 원활하게 유동되므로, 종래와 달리 통기저항이 줄어듦에 따라 발생되는 소음이 저감될 뿐만 아니라, 유입공기의 손실도 줄어들기 때문에, 전체적으로 송풍효율이 증대된다.

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23-10-2017 дата публикации

차량용 공조장치

Номер: KR0101789102B1
Автор: 나민균, 박영덕
Принадлежит: 한온시스템 주식회사

... 본 발명은 블로어 유니트에서 발생한 소음이 차실내로 유입하는 것을 방지하여 차량 실내의 정숙성 및 승차감을 향상시키는 차량용 공조장치에 관한 것으로, 상기 차량용 공조장치는 일 측에 공조케이스(40)에 연결되는 토출구(3a)가 형성되고 상부가 개방된 스크롤 케이스(3)와; 상기 스크롤 케이스(3)의 상부에 설치되고, 내,외기가 각각 유입될 수 있도록 외기유입구(2b)와 그릴(110)이 형성된 내기유입구(2a)가 형성되며, 상기 내,외기유입구(2a)(2b)를 선택적으로 개폐하도록 내,외기 전환도어(2c)가 설치된 인테이크 덕트(2)와; 상기 스크롤 케이스(3)에 회전가능하게 설치되는 블로어(5)와; 상기 블로어(5)를 회전시키도록 상기 스크롤 케이스(3)의 하부에 설치되어 상기 블로어(5)와 연결되는 모터(6);를 포함하여 이루어지는 차량용 공조장치에 있어서, 상기 그릴(110)은, 일정 폭을 갖는 복수의 리브면을 갖도록 형성되며, 상기 복수의 리브면은 상기 블로어(5)의 공기 흡입구 중앙을 중심으로 한 복수의 동심원에 접하는 접선방향으로 연장 형성되는 것을 특징으로 한다.

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22-09-2016 дата публикации

만병초 추출물 또는 이로부터 분리된 메가스티그메인 배당체를 함유하는 패혈증의 예방 또는 치료용 조성물

Номер: KR0101655180B1
Автор: 나민균, 배종섭

... 본 발명은 만병초 추출물 또는 이로부터 분리된 메가스티그메인 배당체를 함유하는 패혈증의 예방 또는 치료용 조성물에 관한 것으로서, 상기 조성물은 혈관내피세포에서 HMGB1(high mobility group box 1)의 발현을 억제하는 효과가 우수하여 패혈증의 예방 또는 치료용 의약 조성물이나 패혈증의 예방 또는 개선용 건강기능식품으로 용이하게 이용가능하다.

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21-02-2019 дата публикации

벼메뚜기 추출물 또는 이로부터 분리한 화합물을 유효성분으로 함유하는 피부주름 개선용 화장료 조성물

Номер: KR0101949956B1
Автор: 채성욱, 임아랑, 나민균

... 본 발명은 화학식 1의 화합물 또는 이의 허용가능한 염; 화학식 2의 화합물 또는 이의 허용가능한 염; 화학식 3의 화합물 또는 이의 허용가능한 염; 또는 화학식 1~3의 화합물 중에서 선택된 하나 이상의 화합물을 포함하는 벼메뚜기(Oxya chinensis sinuosa) 추출물을 유효성분으로 함유하는 피부주름의 예방 또는 개선용 화장료 조성물에 관한 것으로, 자외선 조사에 의한 세포 손상을 억제하며, MMP-1의 발현을 현저하게 억제하므로 피부주름 개선용 화장품으로 활용할 수 있다.

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02-11-2015 дата публикации

SWASH PLATE TYPE COMPRESSOR HAVING VIBRATION REDUCTION FUNCTION

Номер: KR1020150122359A
Принадлежит:

Disclosed is a swash plate type compressor having a vibration reduction function capable of setting each central shaft line at an incline with respect to a central shaft line of a rotary shaft with respect to multiple cylinder bores attended in a radially symmetrical structure around a rotary shaft inside a casing of a compressor, reducing a shaft direction component by generating a vector component generated in a radial direction with respect to a central shaft line of each cylinder bore, thereby reducing a shaft force generated in the direction of a shaft of a cylinder bore when a compressor is driven and minimizing a degree of generating vibrations and noises through the medium of the same. In the disclosed swash plate type compressor, as a central shaft line (165) of a cylinder bore (160) arranged in a radially symmetrical structure with respect to a central shaft line (145) of a rotary shaft (140) is arranged at an incline with respect to the central shaft line (145) of the rotary ...

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24-01-2017 дата публикации

만병초 추출물 또는 이로부터 분리된 메가스티그메인 배당체를 함유하는 패혈증의 예방 또는 치료용 조성물

Номер: KR0101699378B1
Автор: 나민균, 배종섭

... 본 발명은 만병초 추출물 또는 이로부터 분리된 메가스티그메인 배당체를 함유하는 패혈증의 예방 또는 치료용 조성물에 관한 것으로서, 상기 조성물은 혈관내피세포에서 HMGB1(high mobility group box 1)의 발현을 억제하는 효과가 우수하여 패혈증의 예방 또는 치료용 의약 조성물이나 패혈증의 예방 또는 개선용 건강기능식품으로 용이하게 이용가능하다.

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10-06-2016 дата публикации

EXPANSION VALVE OF AIR CONDITIONING SYSTEM FOR AUTOMOTIVE VEHICLES

Номер: KR1020160066123A
Принадлежит:

The present invention relates to an expansion valve of an air-conditioning system for an automotive vehicle which prevents a refrigerant leakage sound as well as a refrigerant contact noise from a baffle plate by improving the structure of the baffle plate installed on the lower portion of a throttling flow pathway, and thus riding comfort for passengers is enhanced. Accordingly, the present invention relates to the expansion valve of an air-conditioning system for an automotive vehicle, equipped with the throttling flow pathway expanding high-pressure refrigerant introduced from the condenser under lower pressure and inputting the refrigerant to an evaporator, comprising: a space expansion-type baffle plate installed on a downstream side of the throttling flow pathway. The space expansion-type baffle plate comprises: a baffle hole capable of allowing a predetermined amount of refrigerant on the downstream side of the throttling flow pathway to pass through; a baffling plate body unit controlling ...

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13-07-2017 дата публикации

NOVEL COMPOUND DERIVED FROM SCOLOPENDRA SUBSPINIPES, AND ANTITHROMBOTIC USE THEREOF

Номер: WO2017119562A1
Принадлежит:

The present invention relates to an antithrombotic, antiplatelet and anticoagulant pharmaceutical composition containing, as an active ingredient, a compound isolated from Scolopendra subspinipes. More specifically, the compound of the present invention has effects of extending activated partial thromboplastin time and prothrombin time in human umbilical vein endothelial cells, inhibiting thrombin and activated factor X, inhibiting thrombin-catalyzed fibrin polymerization and platelet aggregation and increasing an antithrombotic effect in a pulmonary thrombosis model and a thrombosis model. In addition, since protein kinase C activity and calcium mobilization is prevented, an anticoagulant effect is caused in mice, and the ratio of plasminogen activator inhibitor-1 to tissue plasminogen activator is decreased, the compound of the present invention can be useful as an active ingredient of an antithrombotic agent, an antiplatelet agent and an anticoagulant.

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28-08-2015 дата публикации

COMPOSITION CONTAINING EXTRACT OF RHODODENDRON BRACHYCARPUM OR MEGASTIGMANE GLUCOSIDES ISOLATED THEREFROM FOR PREVENTING OR TREATING SEPSIS

Номер: KR1020150098460A
Принадлежит:

The present invention relates to a composition containing an extract of Rhododendron brachycapum or megastigmane glucosides isolated therefrom for preventing or treating sepsis. The composition has excellent effect of controlling expression of high mobility group box 1 (HMGB1) in vascular endothelial cells, thereby being easily used as a medical composition for preventing or treating sepsis or a health functional food for preventing or treating sepsis. COPYRIGHT KIPO 2015 ...

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28-04-2016 дата публикации

AIR CONDITIONER FOR VEHICLE

Номер: KR1020160045966A
Принадлежит:

Disclosed is an air conditioner for a vehicle with an improved noise prevention structure which can effectively prevent a phenomenon wherein noise by the flow of a refrigerant escapes to the outside of an evaporator pipe. The air conditioner has an evaporator pipe which connects an evaporator and an expansion valve and enables a refrigerant to flow therein. In the evaporator pipe, a tube is provided to divide the refrigerant and an inner wall surface of the evaporator pipe. Thus, the tube acts as a resistor on a path through which noise by the flow of the refrigerant passes to minimize the noise escaping to the outside of the evaporator pipe. COPYRIGHT KIPO 2016 ...

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22-12-2017 дата публикации

ANTITHROMBOTIC COMPOSITION COMPRISING COMPOUND ISOLATED FROM OXYA CHINENSIS SINUOSA

Номер: KR101811588B1

The present invention relates to an antithrombotic, antiplatelet, or anticoagulant composition which comprises one or more compounds selected from the group consisting of (2R,3R)-2-(3′,4′-dihydroxyphenyl)-3-acetylamino-7-(N-acetyl-2″-aminoethyl)-1,4-benzodioxane (compound 1), (2R,3R)-2-(3′,4′-dihydroxyphenyl)-3-acetylamino-6-(N-acetyl-2″-aminoethyl)-1,4-benzodioxane (compound 2), (2R,3S)-2-(3′,4′-dihydroxyphenyl)-3-acetylamino-6-(N-acetyl-2″aminoethyl)-1,4-benzodioxane (compound 3), and (2R,3S)-2-(3′,4′-dihydroxyphenyl)-3-acetylamino-7-(N-acetyl-2″-aminoethyl)-1,4-benzodioxane (compound 4), all of which are isolated from Oxya chinensis sinuosa. The compounds suppress a blood coagulation pathway by suppressing FXa in HUVEC, and suppress coagulation of platelets in vivo and in vitro, and thus may be beneficially used in pharmaceutical compositions or functional health foods for treating or preventing vascular diseases related to such blood coagulation. COPYRIGHT KIPO 2018 ...

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15-12-2016 дата публикации

EXPANSION VALVE

Номер: KR1020160143944A
Принадлежит:

Disclosed is an expansion valve to solve the problem with respect to noise by discharging liquefied refrigerant to an orifice hole in advance to discharge gasified refrigerant when the refrigerant flowing into the expansion valve is separated to be liquefied and gasified. The expansion valve comprises: a valve body in which a first flow path and a second flow path for the inflow and outflow of refrigerant are formed; a rod provided to slide in the valve body; a head provided at one side of the valve body, and moving the rod to reciprocate in accordance with a temperature of the refrigerant; an elastic member provided in the second flow path for an elastic force to be applied to the rod; an opening and closing unit provided between the rod and the elastic member to open and close an orifice hole of the second flow path; and a liquefied refrigerant guide unit discharging liquefied refrigerant of refrigerant flowing into the second flow path to the orifice hole in advance compared to gasified ...

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28-04-2016 дата публикации

AIR CONDITIONING SYSTEM FOR VEHICLE

Номер: KR1020160045970A
Принадлежит:

The present invention relates to an air conditioning system for a vehicle. An objective of the present invention is to change a structure of an air conditioning case to prevent whistle noise and air blowing noise produced in a small gap between a temporary door and a door seating surface to improve comfort in a vehicle. To achieve the objective, the air conditioning system for a vehicle comprises a door seated on a door seating surface of an air passage or separated from the door seating surface to block or allow a flow of air, and has an empty space of a closed structure formed on the inside of the door seating surface during an injection molding process of an air conditioning case. The air conditioning system for a vehicle further comprises an air inflow hole formed on a portion of the door seating surface to allow air passing though a small gap between the door and the door seating surface to flow into the empty space of the air conditioning case when the door is controlled to a position ...

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12-02-2018 дата публикации

흰점박이꽃무지 유충으로부터 분리된 화합물을 함유하는 항혈전용 조성물

Номер: KR0101828294B1

... 본 발명은 흰점박이꽃무지로부터 분리된 5-히드록시인돌린-2-온(5-hydroxyindolin-2-one, 화합물 1) 및 1-메틸-1,2,3,4-테트라히드로-β-카르볼린-3-카르복실산(1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid, 화합물 2) 중 1종 이상 선택되는 화합물을 함유하는 항혈전, 항혈소판 또는 항응고용 조성물에 관한 것이다. 상기 화합물은 HUVEC에서 FXa 및 트롬빈 생산의 억제를 통해 외인적 및 내인적 혈액 응고 경로를 억제하고, TNF-α에 의해 유도된 PAI-1의 분비를 억제하며, 생체내외에서 혈소판 응집을 억제하고, 단백질 키나제 C 및 칼슘 동원을 특이적으로 방지함으로써, 이런 혈액응고와 관련된 혈관 질환의 치료 또는 예방을 위한 약학적 조성물 또는 건강기능식품으로서 유용하게 사용할 수 있다.

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16-12-2015 дата публикации

Air conditioner for vehicle

Номер: KR0101578098B1
Автор: 나민균
Принадлежит: 한온시스템 주식회사

... 본 발명은, 입구측에 공기유입구가 형성되고 출구측에는 디프로스트 벤트, 페이스 벤트, 플로어 벤트가 형성되며, 냉/온기 또는 냉기와 온기를 상기 벤트로 안내하기 위해 공통적으로 사용되는 공기통로가 형성되며, 상기 벤트들중 상기 플로어 벤트의 입구부가 상기 공기통로에 가장 인접하여 형성된 공조케이스를 포함하여 이루어진 차량용 공조장치에 있어서, 상기 플로어 벤트의 입구부와 상기 공기통로(MC)를 선택적으로 개폐하는 로터리 타입 플로어 도어와; 상기 공기통로(MC)내의 공기 유동 방향을 가변시켜 공기가 안내되도록, 상기 공기통로(MC)상에 설치되며, 상기 로터리 타입 플로어 도어와 연동되는 공기 안내도어를 포함하는 것을 특징으로 한다. 이와 같은 본 발명의 특징적인 구성에 의해 냉기와 온기의 혼합성이 향상되어 공조케이스에서 토출되는 공기의 상,하 온도차를 줄여 탑승자의 쾌적성을 향상시킬 수 있게 된다.

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29-04-2016 дата публикации

Composition comprising hyperoside for preventing or treating sepsis

Номер: KR0101616872B1
Автор: 나민균, 배종섭

... 본 발명은 하이페로사이드(hyperoside)를 함유하는 조성물에 관한 것으로서, 상기 조성물은 혈관내피세포에서 HMGB1(high mobility group box 1)의 발현을 억제하는 효과가 우수하여 패혈증의 예방 또는 치료용 의약 조성물이나 패혈증의 예방 또는 개선용 건강기능식품으로 용이하게 이용가능하다.

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21-03-2017 дата публикации

COMPOSITION CONTAINING COMPOUND ISOLATED FROM SALICORNIA HERBACEA, AND PREVENTING OR TREATING VASCULAR INFLAMMATION OR SEPSIS

Номер: KR101718357B1

The present invention relates to a composition for preventing or treating vascular inflammation or sepsis, wherein the composition contains a compound derived from Salicornia herbacea. The compound, as a flavanone or chromone derivative, inhibits the expression of high mobility group box 1 (HMGB1), and has an excellent effect in controlling the mortality of a mouse according to a cecal ligation and puncture (CLP) operation scheme. Thus, the compound can be easily used as a medical composition for preventing or treating vascular inflammation or sepsis or as a health functional food for preventing or alleviating vascular inflammation or sepsis. COPYRIGHT KIPO 2017 (AA) Compound 1 (BB) Compound 2 (CC) Compound 3 (DD) Compound 4 (EE) Compound 5 (FF) Compound 6 ...

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18-09-2017 дата публикации

COMPOSITION COMPRISING COMPOUNDS ISOLATED FROM SALICORNIA HERBACEA L. FOR PREVENTING OR TREATING VASCULAR INFLAMMATION OR SEPSIS

Номер: KR1020170104920A
Принадлежит:

The present invention relates to a composition comprising compounds isolated from Salicornia herbacea L. for preventing or treating vascular inflammation or sepsis. The compounds are flavanone or chromone derivatives and are effective in suppressing expression of high mobility group box 1 (HMGB1) and mortality of mice according to cecal ligation and puncture (CLP) operation, thereby being used as a pharmaceutical composition for preventing or treating vascular inflammation or sepsis or a health functional food for preventing or alleviating vascular inflammation or sepsis in an easy manner. COPYRIGHT KIPO 2017 (AA) Compound 1 (BB) Compound 2 (CC) Compound 3 (DD) Compound 4 (EE) Compound 5 (FF) Compound 6 ...

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17-08-2017 дата публикации

EXPANSION VALVE OF AIR CONDITIONING SYSTEM FOR VEHICLES

Номер: KR1020170094035A
Принадлежит:

The purpose of the present invention is to provide an expansion valve of an air conditioning system for a vehicle, which is capable of preventing a refrigerant leakage sound coming from a throttle channel caused by variation of pressure of a refrigerant by maintaining the pressure of the refrigerant downstream of the throttle channel constant without being affected by a flow rate of the refrigerant, thereby improving ride quality and comfort in the interior of the vehicle. To this end, provided is the expansion valve of the vehicle air conditioning system having a throttle channel expanding a high-pressure refrigerant introduced from a condenser for the refrigerant to have a low pressure and introducing the refrigerant to an evaporator. The expansion valve includes a flexible inner tube on a downstream side of the throttle channel so that the flexible inner tube can induce the refrigerant moving from the throttle channel and discharge the same to an inlet pipe side of the evaporator. Since ...

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21-11-2013 дата публикации

NOVEL USE FOR ASTERUBIN

Номер: WO2013172528A1
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing or treating metabolic syndrome and to a food composition for preventing or alleviating metabolic syndrome, the composition comprising asterubin (asterubine) or a pharmaceutically acceptable salt thereof as an active ingredient. The asterubin of the present invention exhibits an effect whereby the phosphorylation of AMPK (AMP-activated protein kinase) and ACC (acetyl-CoA carboxylase) is increased and the glucose absorption ability of muscle cells is increased, and so can advantageously be used in pharmaceutical compositions and health and functional foods for preventing or treating metabolic syndrome based on this effect.

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18-07-2017 дата публикации

NOVEL COMPOUND DERIVED FROM SCOLOPENDRID AND ANTITHROMBOTIC USE THEREOF

Номер: KR1020170083291A
Принадлежит:

The present invention relates to a pharmaceutical composition for antithrombotic, antiplatelet, and anticoagulant purposes, containing compounds which are represented by chemical formula 1, 2, and 3 and isolated from scolopendrid, or a pharmaceutically acceptable salt thereof as an active ingredient. The compounds represented by chemical formula 1, 2, and 3 can be useful as active ingredients for antithrombotics, antiplatelet drugs, and anticoagulants. COPYRIGHT KIPO 2017 ...

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