09-05-2013 дата публикации
Номер: US20130116258A1
Described herein are compounds that are androgen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such androgen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon androgen receptors. 2. The compound of claim 1 , or a pharmaceutically acceptable salt claim 1 , or N-oxide thereof claim 1 , wherein:{'sup': '1', 'sub': 3', '6, 'both Rare taken together with the carbon atom to which they are attached to form a C-Ccycloalkyl;'}or{'sup': '1', 'sub': 1', '4, 'each Ris independently C-Calkyl;'}X is S;ring B is phenyl;{'sup': '4', 'sub': 1', '6', '1', '6', '1', '6, 'Ris H, halogen, —CN, —OH, C-Cfluoroalkyl, C-Cfluoroalkoxy, or C-Calkoxy;'}{'sup': 5', '9', '9', '10', '10', '9', '10', '9', '9', '9', '1', '2', '6, 'sub': 2', '2', '2', '2', '2', '2', '2', '1', '10', '1', '10', '1', '10', '1', '10', '1', '10', '3', '10', '2', '10, 'claim-text': [{'sup': '1', 'sub': 2', '2, 'Lis absent, —O—, —S—, —S(O)—, —S(O)—, —NH—, —C(═O)—, —C(═O)NH—, or —S(═O)NH—;'}, {'sup': '2', 'sub': 1', '6', '1', '6', '1', '6, 'Lis C-Calkylene, C-Cfluoroalkylene or C-Cheteroalkylene;'}, {'sup': 6', '9', '9', '10', '10', '9', '9', '9, 'sub': 2', '2', '2', '2', '2', '2', '3', '10', '2', '10, 'Ris —CN, —NO, —OH, —OR, —SR, —S(═O)R, —S(═O)R, —S(═O)N(R), —COR, —C(═O)N(R), substituted or unsubstituted C-Ccycloalkyl, substituted or unsubstituted C-Cheterocycloalkyl, substituted or unsubstituted monocyclic heteroaryl, substituted or unsubstituted bicyclic heteroaryl, or substituted or unsubstituted aryl.'}], 'Ris halogen, —CN, —NO, —OH, —OR, —SR, —S(═O)R, —S(═O)R, —S(═O)N(R), —C(═O)R, —COR, —N(R), —C(═O)N(R), C-Calkyl, C-Cfluoroalkyl, C-Cfluoroalkoxy, C-Calkoxy, C-Cheteroalkyl, substituted or unsubstituted C-Ccycloalkyl, substituted or unsubstituted C-Cheterocycloalkyl, substituted or unsubstituted phenyl, substituted or ...
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