06-01-2022 дата публикации
Номер: US20220002288A1
Автор:
Chang Yujie,
Lin Zeqi,
Lv Kunzhi,
Quan Xu,
Wang XiaoWei,
WANG Yazhou,
Wang Yong,
Xu Tao,
Zhang Jian,
Zhang Xiaoping,
ZHAO Liwen
Monobactam compounds and a use therefor. Specifically provided are chemical compounds represented by formula (I) or isomers, pharmaceutically acceptable salts, solvates, crystals, or prodrugs thereof, preparation methods therefor, pharmaceutical compositions containing said compounds, and a use of said compounds or compositions in treating bacterial infection. The present compounds feature excellent antibacterial activity, and have great hopes of becoming a therapeutic agent for bacterial infection. 110-. (canceled)12. The compound according to claim 11 , or an isomer claim 11 , pharmaceutically acceptable salt claim 11 , solvate claim 11 , crystal or prodrug thereof claim 11 , whereinL is selected from the group consisting of —C(O)NH— and —NHC(O)—; and{'sup': 5', '6, 'sub': 1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '2-6', '2-6', '3-8', '1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '1-6', '1-6, 'Rand Rare each independently selected from the group consisting of halogen, hydroxy, Calkyl, haloCalkyl, hydroxyCalkyl, aminoCalkyl, Calkoxy, haloCalkoxy, hydroxyCalkoxy, aminoCalkoxy, nitro, carboxy, cyano, amino, monoCalkylamino, Calkylamido, aminoCalkylamido, hydroxyaminoCalkylamido, Calkylacyl, carbamoyl, Calkylcarbamoyl, diCalkylamino, Calkenyl, Calkynyl, Ccycloalkyl, 3-8 membered heterocyclyl, 3-8 membered heterocyclylCalkyl, amino 3-8 membered heterocyclyl, aminoCalkyl 3-8 membered heterocyclyl, hydroxyCalkyl 3-8 membered heterocyclyl, aryl, 3-8 membered heteroaryl and oxo, which is optionally substituted by amino, aminoCalkyl, Calkylamino, halogen, hydroxy, Calkyl, haloCalkyl, hydroxyCalkyl, Calkoxy, haloCalkoxy, hydroxyCalkoxy, aminoCalkoxy, nitro, carboxy or cyano.'}16. A pharmaceutical composition comprising the compound according to claim 11 , or an isomer claim 11 , pharmaceutically acceptable salt claim 11 , solvate claim 11 , crystal or prodrug thereof claim 11 , and a ...
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