Five-membered heterocyclic amides wnt pathway inhibitor

Disclosed in the present invention is a five-membered heterocyclic amides Wnt pathway inhibitor, belonging to compounds that regulate the activities of a Wnt signaling pathway, and a method for preparing such compounds and use of such compounds in preparing drugs for antagonizing a Wnt signaling pathway are provided. The five-membered heterocyclic amides Wnt pathway inhibitor provided in the present invention has remarkable anti-tumor activities on the basis of a rational drug design for targets, and can be used in developing a new generation of Wnt pathway inhibitor, having a high clinical application value and a considerable market potential.

Structure and process of internally buried package

The invention discloses a process for an internally buried package. The process comprises the following steps: firstly, providing a metal core layer which is provided with a first surface, a second surface relative to the first surface, an opening for communicating the first surface and the second surface and a plurality of through holes; secondly, arranging a chip in the opening; thirdly, forming a dielectric layer in the opening and the through holes to fix the chip in the opening; fourthly, forming a plurality of conductive passages in the through holes respectively, and insolating the conductive passages from the metal core layer by the part of the dielectric layer positioned in the through holes; and finally, forming a line structure on the first surface of the metal core layer by a layer increasing method, and electrically connecting the line structure, the chip and the conductive passages.

Weighing type oil well metering device

The utility model provides a weighing type oil well metering device. A first liquid inlet, an inner cavity and a first liquid outlet are sequentially communicated. The device further comprises a liquid storage tank, the liquid storage tank is arranged in the inner cavity, the first liquid inlet is communicated with the second liquid inlet, the second liquid outlet is communicated with the first liquid outlet or the inner cavity, and the second liquid inlet, the liquid storage cavity and the second liquid outlet are sequentially communicated; the weighing assembly is connected with the liquid storage tank; the liquid discharging switch assembly is used for cutting off or communicating the second liquid outlet; oil enters the oil storage tank through the first liquid inlet and the second liquid inlet in sequence, the weighing assembly measures the mass of the oil entering the liquid storage tank, the liquid discharging switch assembly is communicated with the second liquid outlet after measurement ...

Degradation-controllable absorbable medical anti-adhesion membrane and preparation method thereof

The invention discloses a degradable and controllable absorbable medical anti-adhesion membrane and a preparation method thereof. The method comprises the following steps: firstly, mixing recombinant humanized collagen with a cross-linking agent for in-situ cross-linking, then adding glycerol, pouring into a mold to form prefabricated glue, and carrying out secondary drying and primary rinsing to finally prepare the absorbable medical anti-adhesion membrane. The absorbable medical anti-adhesion membrane prepared by the invention has the advantages of controllable degradation period, good flexibility and deformation resistance, strong water absorption capacity and good biocompatibility, complete degradation products are amino acids, the amino acids can be completely absorbed by a human body, the safety is high, and the absorbable medical anti-adhesion membrane can be taken out without secondary operation after being used once.

Feed device of straw packaging machine

The invention discloses a feed device of a straw packaging machine. The feed device comprises a frame, a breaking device, a buffer cage, a supporting rod and a transmission device. The breaking device comprises a rotating shaft, a plurality of rotating plates and breaking tools. The rotating shaft mounted at one end of the frame is connected with the transmission device. The rotating plates are mounted on the rotating shaft. The breaking tools are arranged on the rotating plates. One end of the buffer cage is connected to the frame through a shaft, and the other end of the buffer cage is connected with the supporting rod. The buffer cage is composed of a plurality of ribs. Semi-circular arc structures are formed in the middles of the ribs spaced with the rotating plates. The supporting rod and the transmission device are arranged on the frame. According to the arrangement, the straws are broken into uniform size for packaging convenience and effect by the packaging machine; discharge speed ...

Energy -conserving vibration fluidized bed dryer

The utility model discloses an energy -conserving vibration fluidized bed dryer, the processing of mainly used chicken essence seasoning, including box, upper cover, the box middle part is equipped with the fluidization bed board, the fluidization bed board with be equipped with shock dynamo between the bottom half, one side of box is equipped with the air intake, air intake department is equipped with the air heater, the air intake for the opposite side of air heater is equipped with the steam heat air curtain, the steam heat air curtain with be equipped with the air register between the air heater, the box for the opposite side of air intake is equipped with the discharge gate, the upper cover top is equipped with the air outlet, be equipped with bag dust filter in the air outlet. Have that drying rate is fast, energy saving, the occupation of land is little, the big energy consumption of productivity is little, the recruitment is few a great deal of advantage.

GPS Beidou dual-mode positioning device

The invention relates to a GPS Beidou Dual-mode positioning device, and solves the problem about only one positioning signal. According to the technical scheme, the GPS Beidou dual-mode positioning device is powered by a power supply; the power is divided into input power, standby power and digital power after voltage transformation is performed through a low dropout voltage regulator; the GPS Beidou Dual-mode positioning device comprises a baseband chip circuit, a first navigation radio frequency circuit, a second navigation radio frequency circuit, a low-noise amplifier, a Beidou navigation module and a reset circuit, wherein the Beidou navigation module is electrically connected with the baseband chip circuit, and is also in circuit connection with the first navigation radio frequency circuit and the second navigation radio frequency circuit through the low-noise amplifier; the first navigation radio frequency circuit is electrically connected with the second navigation radio frequency ...

Preparation method of needle mushroom noodles

The invention relates to the technical field of food, and in particular relates to a preparation method of needle mushroom noodles. The preparation method comprises the following steps: adding fresh needle mushroom or needle mushroom root and water to a pulping machine to prepare pulp, thus obtaining needle mushroom pulp; and adding the needle mushroom pulp to flour and kneading dough to obtain needle mushroom noodles. By directly pulping the needle mushroom, the preparation method disclosed by the invention avoids drying and grinding, so as to greatly reduce energy consumption; moreover, the preparation method keeps bioactivities of active substances such as polysaccharide and polyphenol to the greatest extent and improves nutritive value of the needle mushroom noodles; the prepared noodle product is white, so that the product is quite good and high in color grade; the noodle product prepared by the method well keeps dietary fiber; compared with a conventional process, the preparation ...

Nvjindan hot sauce

The invention discloses Nvjindan hot sauce. Tartary buckwheat serves as a main raw material and is matched with water chestnuts, codonopsis lanceolata, bamboo shoot mustard, jumble beads, taro roots, Nvjindan and cynanchum glaucescens, the Nvjindan and the cynanchum glaucescens have healthcare functions, and the hot sauce which is thick, exquisite in mouthfeel, deliciously spicy, tasty and refreshing and has nutrition and healthcare functions is made through the processes of raw material pretreatment, mixing, cooking, starter making, fermentation, milling, sterilization, packaging and the like. A finished product has the healthcare functions of moistening the lung for removing phlegm and promoting the secretion of saliva or body fluid for relieving a cough, can serve as everyday appetizer seasoning or dressing for cold vegetable dishes in sauce by people, and is suitable for people of all ages. The processes are simple and easy to implement.

MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR-GAMMA) FOR USE IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES

The present invention relates to novel retinoid-related orphan receptor gamma (ROR?) modulators and their use in the treatment of diseases mediated by ROR?.

Integral type crystallizer

The invention discloses an integral type crystallizer which comprises a crystallizer body. The crystallizer body is provided with a cooling channel and a crystallizing channel, the crystallizing channel is provided with two oppositely-and-symmetrically-arranged long face walls and two oppositely-and-symmetrically-arranged short face walls, the long face walls have radians, the distances between the two long face walls are gradually reduced from the middle to the two sides, the short face walls are of slant structures, and the distances between the two short face walls are gradually reduced from the upper end to the lower end. According to the integral type crystallizer, the smoothness of the appearance of a cast blank can be improved, and the number of air gaps inside the cast blank can be decreased.

During double -deck vane type is sour and stirring rake

The utility model discloses a during double -deck vane type is sour and stirring rake, including the stirring pivot, stirring pivot upper end is provided with mounting flange, the lower extreme of stirring pivot is provided with the impulse type turbine, still be provided with in the stirring pivot and be located the curved leaf disc turbine of impulse type turbine top, curved leaf disc turbine includes the arc camber blades and is located the connection ring of the upper and lower both sides of arc camber blades, curved leaf disc turbine middle part is provided with the confession the axle center through -hole that the stirring pivot was passed, be provided with flange in the stirring pivot, flange with it is fixed that the connection ring passes through bolted connection. A during double -deck vane type is sour and stirring rake, can stir fully and avoid the lime stone to sink at the end, make the lime stone cyclic motion that suspends in the acid waste water to evenly distributed each ...

Novel compounds

本發明係關於新穎類視色素相關之孤兒受體伽瑪(RORγ)調節劑及彼等於治療由RORγ媒介的疾病之用途。

MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR-GAMMA) FOR USE IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES

The present invention relates to novel retinoid-related orphan receptor gamma (ROR?) modulators and their use in the treatment of diseases mediated by ROR?.

Built-in capacity cell structure and method for producing same

The present invention relates to a buried capacitive component structure and a manufacturing method of the buried capacitive component structure. The buried capacitive component structure comprises a dielectric layer, a first conducting layer, a second conducting layer, a first panel and a second panel, wherein, the dielectric layer is provided with a thickness. The first conducting layer is positioned on the one side of the dielectric layer, and provided with a first electrical property. The second conducting layer is positioned on the other side of the dielectric layer relative to the first conducting layer, and provided with a second electrical property. The first panel is inserted in the middle of the dielectric layer, and electrically connected with the first conducting layer. The second panel is inserted in the middle of the dielectric layer, and electrically connected with the second conducting layer, and away from a certain distance with the first panel.

Small-end inclined plane center thickness detection device for engine connecting rod production

The utility model provides a small head inclined plane center thickness detection device for engine connecting rod production, comprising a detection bench, a positioning assembly, a calibration block and a dial indicator, the positioning assembly comprises a small head positioning seat and a large head positioning seat, the dial indicator is vertically arranged on a connecting rod, and one end of the connecting rod is provided with a fine tuning assembly. The other end of the connecting rod is arranged on the moving assembly, the moving assembly is movably arranged on the guide rail, limiting columns used for limiting the moving assembly are arranged at the two ends of the guide rail, and the large-head positioning base comprises a large-head base plate, a first protrusion and a second protrusion. According to the device, the dial indicator can continuously move between the calibration block and the workpiece through the moving assembly and the guide rail, and the position of the dial ...

Field graphite grounding equipment

A piece of field graphite grounding equipment comprises a frame, and wheels, a handle, a soil loosening device and a ditching device which are detachably arranged on the frame. The soil loosening device comprises a main shaft, a cutter shaft sleeve, coulter blades and a chain transmission mechanism. The ditching device comprises a forming soil arching head detachably arranged on the vertical lower portion of the frame. The whole structure of the equipment can be separated from and assembled with the frame, the size is reduced, split charging and sharing are facilitated, and the equipment is easier to carry in field trudge. By means of the soil loosening device arranged at the foremost end of the frame, in the process that an operator pushes the frame to advance (or a motor is additionally arranged to drive the wheels to advance), a coulter is utilized to break into a soil layer firstly to loosen soil. After the coulter enters the soil, the forming soil arching head follows up subsequently ...

CoAlCuFeNiB series high-entropy amorphous alloy capable of degrading sewage and realizing double effects of hydrogen evolution and oxygen evolution and application of CoAlCuFeNiB series high-entropy amorphous alloy

The invention discloses a CoAlCuFeNiB series high-entropy amorphous alloy capable of degrading sewage and realizing double effects of hydrogen evolution and oxygen evolution and application, and relates to a high-entropy amorphous alloy and application. The invention aims to solve the problems that an existing catalyst material is low in degradation efficiency and difficult to be suitable for sewage degradation in neutral and alkaline environments, and an amorphous material cannot meet the double-effect requirements of sewage degradation and hydrogen and oxygen evolution at the same time. The invention discloses a CoAlCuFeNiB series high-entropy amorphous alloy capable of degrading sewage and realizing double effects of hydrogen evolution and oxygen evolution. The chemical general formula of the CoAlCuFeNiB series high-entropy amorphous alloy is CoaAlbCucFedNieBf according to atomic percent, according to the application, the CoAlCuFeNiB series high-entropy amorphous alloy serves as a catalyst ...

Flexible covalent organic framework nanofiber membrane, electrochromic device and preparation method

The invention relates to a flexible covalent organic framework nanofiber membrane, an electrochromic device and a preparation method, and the preparation method of the electrochromic device comprises the following steps: adding a covalent organic framework monomer A into a polyacrylonitrile solution, and carrying out electrostatic spinning to obtain a composite nanofiber membrane A; preparing a mixed solution B, and immersing the composite nanofiber membrane into the mixed solution B for reaction to obtain a composite nanofiber membrane B; soxhlet extraction is carried out, such that a covalent organic framework nanofiber electrochromic film is obtained; and forming a gel electrolyte layer on the single-layer coated covalent organic framework nanofiber membrane, covering an ITO (Indium Tin Oxide) transparent conductive thin film, sealing with epoxy resin, and connecting with a power supply to obtain the flexible electrochromic device containing the covalent organic framework nanofiber.

Communication implementation method, virtual machine program product, modem and terminal

A method for implementing communication includes: determining an operating system corresponding to a current time slice, the determined operating system supporting a communication network standard; determining a memory partition; running the determined operating system based on the determined memory partition and driving a Digital Signal Processor, a signal processing module supporting the communication network standard and a Radio Frequency signal transceiver based on a hardware driving program included in a system program of the determined operating system; controlling the signal processing module to read authentication information of the terminal and controlling the Digital Signal Processor to encapsulate, based on a communication protocol, the authentication information of the terminal to generate a communication network signal; and controlling the Radio Frequency signal transceiver to convert the communication network signal into a Radio Frequency signal and send the Radio Frequency signal to a communication network.

Modulators of the retinoid-related orphan receptor gamma (ROR-gamma) for use in the treatment of autoimmune and inflammatory diseases

The present invention relates to novel retinoid-related orphan receptor gamma (ROR) modulators and their use in the treatment of diseases mediated by ROR.

Method and its device for time service based on GPS technology

The invention relates to a method and a device for carrying out calibration and timing of an electric meter, in particular to the method which carries out the timing of the electric meter on the basis of the GPS technology and the device thereof. The method which carries out the timing of the electric meter on the basis of the GPS technology comprises the following steps of: a. using the GPS to obtain the current time information; b. calibrating the current time at the definite time; c. carrying out the timing of the electric meter by a broadcast communication mode. The invention further discloses the device for carrying out the timing of the electric meter on the basis of the GPS technology, comprising a GPS receiving module, an MCU module and a broadcast communication module. The method and the device can ensure the accuracy of a clock of the electric meter and prevent the time and the date from being forged and modified illegally. At the same time, the method and the device are characterized ...

Salinized soil roadbed model test device in different working condition modes

The invention relates to the technical field of salinized soil, in particular to a salinized soil roadbed model test device under different working condition modes, solves the problem that in the prior art, in order to use salinized soil in a larger range and meet the engineering construction requirement of a salinized soil area, provides a reasonable judgment basis for the applicability of a roadbed filler in the salinized soil area, and improves the construction efficiency. And the salinized soil roadbed structure needs to be tested under different working conditions. A saline soil roadbed model test device in different working condition modes comprises a supporting base, two supporting side frames fixedly connected to the two sides of the top of the supporting base and two driving mechanisms arranged on the top of the supporting base in a mirror image mode, and the two sides of the two driving mechanisms are detachably connected with the side walls of the adjacent supporting side frames ...

Visual Immunochromatographic Detection Method with Black Phosphorus-Based Colorimetric/Photothermal Dual Modes for Rapid Detection of Norfloxacin

Abstract The disclosure relates to the technical field of detection with immunochromatographic test strips (ICSs), and provides a visual immunochromatographic detection method with black phosphorus (BP)-based colorimetric/photothermal dual modes for rapid detection of norfloxacin (NFX). A strip used in the detection method includes a bottom plate and a sample application pad, a conjugate pad, a nitrocellulose membrane and a water absorption pad sequentially adhered to the bottom plate, where the nitrocellulose membrane includes a test area and a control area; and the sample application pad is dripped with BP nanosheets. The BP nanosheets dripped to the sample application pad of the disclosure are used as a colorimetric/photothermal developing agent. Colorimetric/photothermal data can be obtained by collecting and analyzing heat on a T line. A "colorimetric/photothermal dual readout" method improves detection accuracy.

COMPOUNDS

Ginkgo and adenophora stricta health care rice crust

The invention discloses ginkgo and adenophora stricta health care rice crust. Ginkgoes which are rich in nutritional ingredients, and have the effects of nourishing yin, maintaining beauty, tonifying the lung and protecting the liver as 'materials with the functions of both food and medicine' published by the Ministry of Health are selected, the ginkgoes are added into rice together with radix glehniae which has the effects of nourishing yin, moistening lungs, tonifying stomach and promoting fluid and sweet potatoes which are rich in lysine, and have the effects of tonifying kidney and spleen and loosening the bowel to relieve constipation, the roasting operation and the like are performed to obtain the finished product; the finished sweet potato rice crust has the advantages that the sweet potatoes contain rich lysine to supplement lysine lacked in conventional rice, so that the comprehensive nutrition is realized, and the crust is uniform in thickness, flat block-shaped, and uniform faint ...

Modulators of the retinoid-related orphan receptor gamma (ROR-gamma) for use in the treatment of autoimmune and inflammatory diseases

The present invention relates to novel retinoid-related orphan receptor gamma (ROR) modulators and their use in the treatment of diseases mediated by ROR.

Rail driving mechanism of movable-static rail type casting hydraulic handling device

The invention discloses a rail driving mechanism of a movable-static rail type casting hydraulic handling device. The rail driving mechanism comprises a frame (1), columns (2), movable connecting rods (3), eccentric shafts (4), mandrels (41), a movable rail (8) and a static rail (7). The eccentric shafts (4) are driven to rotate back and forth through extension movement of hydraulic cylinders (6) so as to enable the static rail (7) to reciprocate up and down, and the static rail (7) is driven through the hydraulic cylinders (6) to move bilaterally so as to realize transportation of sand molds, so that a phenomenon that the sand molds are scattered and damaged due to vibration in the process of traditional crane lifting and locomotive transportation is effectively avoided, and the qualified rate of products is increased.

Lifting double-groove rope wheel

The lifting double-groove rope wheel comprises a motor base, a motor is arranged on the upper surface of the motor base, a rope wheel is arranged at the motor shaft end of the motor, a check ring is fixedly connected to the outer side face of a motor shaft, the rope wheel is located on the left side of the check ring, a shaft end plate is sleeved on the motor shaft on the left side of the rope wheel, and a fastening nut is arranged on the left side of the shaft end plate. An outer wheel groove and an inner wheel groove which are distributed in parallel are formed in the outer side face of therope wheel, an upper through hole and a lower through hole which are vertically symmetrical are formed in the left side of the bottom of the outer wheel groove, an inner through hole is formed betweenthe outer wheel groove and the bottom of the inner wheel groove, and a rope locking mechanism is arranged on the outer end face of the rope wheel. The double-groove rope wheel can control the steel wire ...

Covalent organic framework composite nanofiber electrochromic film and preparation and application thereof

The invention relates to a covalent organic framework composite nanofiber electrochromic film as well as a preparation method and application thereof. The preparation method comprises the following steps: preparing a polymer solution; adding tris (4-aminophenyl) amine into the polymer solution, and stirring to obtain a mixed solution; performing electrostatic spinning to obtain a composite nanofiber membrane; the preparation method comprises the following steps: dissolving thieno [3, 2-b] thiophene-2, 5-diformaldehyde and a catalyst in a solvent to obtain a reaction solution; immersing a nanofiber membrane into the reaction solution, and reacting to obtain a crude product; and washing and drying the crude product to obtain the covalent organic framework composite nanofiber electrochromic film. Compared with the prior art, the covalent organic framework in the prepared nano composite fiber membrane grows uniformly on the fiber surface, and the covalent organic framework agglomeration or ...

Health care nutrition composition capable of relieving asthenopia as well as preparation method and application thereof

The invention discloses a health care nutrition composition capable of relieving asthenopia as well as a preparation method and application thereof. The composition comprises the following raw materials in parts by weight: 20-50 parts of germinative highland barley powder, 5-20 parts of oat powder, 6-16 parts of milk powder, 1-5 parts of yak bone meal, 1-5 parts of fructus lycii powder, 0.1-1 part of taurine, 0.1-1 part of xanthophylls ester micro-capsule powder, 8-15 parts of malt extract, 25-55 parts of white granulated sugar, 0.2-1 part of DHA micro-capsule powder, 2-8 parts of fructo-oligose and 2-10 parts of cocoa powder. The health care nutrition composition has the efficacy of relieving asthenopia according to demands of modern consumers, is natural in raw materials, free of any side effect and well received by the consumers, and tastes excellent.

Voltage mutual inductor resonance step-up method in related full closed combined electrical equipment

The invention relates to a resonance boosting method of a voltage mutual inductor of a relevant fully enclosed composite apparatus. The method of the invention comprises the following steps: firstly, utilizing a variable-frequency power supply to mark the reactive values of different adjusting positions of an adjustable reactor, secondly, utilizing the variable-frequency power supply to guide inductance changes to measure capacitance parameters of the fully enclosed composite apparatus namely a GIS pipeline in situ, thirdly, adjusting the inductance value of the adjustable reactor according to measured equivalent capacitance Cx of a capacitance type mutual inductor and GIS pipeline capacitance, enabling a resonance circuit to reach resonance boosting in 50Hz series resonance, and finishing boosting experiments of a capacitance type potential transformer in GIS. The beneficial effects of the invention is to improve the experiment working efficiency greatly and to save time and labor.

Substrate with built-in chip and manufacturing method thereof

The invention discloses a substrate with a built-in chip. The substrate with the built-in chip comprises a first insulating layer, a core layer, a chip, a second insulating layer, a first circuit layer and a second circuit layer, wherein the core layer is arranged on the first insulating layer and is provided with an opening to ensure that part of the first insulating layer is exposed; the chip is fixed in a groove formed by the opening and the first insulating layer; the second insulating layer is arranged on the core layer in order to cover the chip; the first circuit layer is arranged outside the first insulating layer; the first insulating layer is positioned between the first circuit layer and the core layer; the second circuit layer is arranged outside the second insulating layer; the second insulating layer is positioned between the second circuit layer and the core layer; the first circuit layer is in electric connection with the second circuit layer; and the second circuit layer ...

Dust device at stirring station

The utility model discloses a dust device at stirring station has solved and has told time sending out a police dispatch as dust detector, and when the operational environment who gives the stirring station that does not have that the operator can be timely carried out timely dust lowering processing, the dust existed always to lead to the too high problem of dust concentration, its technical scheme main points are including dust detector, dust detector is connected with the driver, the driver starts when dust detector detects to the default, driver swivelling joint has the atomization component who is used for converting water to the atomizing form, reaches the automatic spraying water mist of dust detector dust device when reaching the default to the effect of dust content in the reduction air.

Hierarchical distributed processing system for construction, weather and cost information and processing method thereof

The invention provides a hierarchical distributed processing system for construction, weather and cost information. The hierarchical distributed processing system comprises information input terminals, storage systems, a control subsystem and an instruction terminal, wherein the information input terminals are used for inputting construction, weather or cost information of a section of an express highway; the storage systems are connected with the information input terminals and are used for storing the information input to the information input terminals; the control subsystem is connected with the storage systems through a network and comprises a first-stage controller, a second-stage controller, a third-stage controller and a fourth-stage controller which are sequentially connected through a network; the instruction terminal is used for inputting instructions and receiving information and comprises a first-stage port connected with the first-stage controller, a second-stage port connected ...

Application program image display method and device

The embodiment of the invention discloses application program image display method and device. The method comprises the following steps of: receiving a display request from a second operation system, and reading an application program image stored in a storage region; judging whether the application program image needs to be processed by a windows manager according to the configuration of a localimage display system; if so, sending the application program image to the windows manager and sending the application program image processed by the windows manager to a graphic display library for processing; otherwise, directly sending the application program image to the graphic display library for processing; acquiring the position of a display memorizer through a display driver, and sending the application program image processed by the graphic display library to the display memorizer, and displaying the application program image through the display memorizer. The embodiment of the invention ...

A electrical control raceway for concrete mixing plant

The utility model discloses an electrical control raceway for concrete mixing plant has solved when the completion is added water through the closed raceway of valve, because the bore of raceway is great, at the closed in -process of valve, still has a large amount of water to flow out in the raceway, the lower problem of precision of adding water of raceway, and its technical scheme main points are: be responsible for and count the water tank including the water delivery, the delivery pipe branch that is equipped with and counts the water tank intercommunication and to set up is responsible for in the water delivery, and the delivery pipe branch bore is lighter than the water delivery and is responsible for the bore, and the delivery pipe branch is equipped with first ball valve, and thewater delivery is responsible for and is equipped with the second ball valve, is equipped with the drive assembly of the first ball valve of drive and second ball valve switching between first ball valve ...

Application of traditional Chinese medicine composition in preparation of drug for treating chronic obstructive pulmonary disease (COPD)

The invention relates to an application of a traditional Chinese medicine composition in preparation of a drug for treating chronic obstructive pulmonary disease (COPD). The active components of the traditional Chinese medicine composition mainly comprises: exocarpium citrus grandis, honey-fried radix stemonae, poria cocos, pinellia ternata (preparata), cynanchum glaucescens, radix glycyrrhizae, apricot kernel and schisandra chinensis. A pharmacodynamic research result proves that the traditional Chinese medicine composition has significant curative effects of relieving cough and dispelling phlegm on patients in a stable period of the COPD, is quick in effects, is stable in curative effects with the taking time prolonged, and meanwhile alleviates physiological and psychological burdens of patients and further improves life quality of the patients. The advantages of the traditional Chinese medicine composition are greatly in clinical significance. The traditional Chinese medicine composition ...

Dynamic-and-static-rail-type casting hydraulic carrying device

The invention discloses a dynamic-and-static-rail-type casting hydraulic carrying device which comprises a frame (1), stand columns (2), a movable connecting rod (3), eccentric shafts (4), mandrels (41), dynamic rails (8) and static rails (7). The eccentric shafts (4) are driven to rotate in a reciprocating mode through telescopic movement of hydraulic cylinders (6), and therefore the dynamic rails (8) move upwards and downwards in a reciprocating mode; the hydraulic cylinders (6) drive the dynamic rails (8) to move in a front-and-back mode in the rail direction, conveying of sand moulds is achieved, the phenomenon that in the traditional crane hoisting and crane conveying processes, the sand moulds are scattered and damaged because of vibration is effectively reduced, and the product percent of pass is increased.

Accomodate convenient clearance gauge

The utility model discloses an accomodate convenient clearance gauge, its technical scheme main points are including the clearance gauge body, it is articulated with the clearance gauge handle that clearance gauge handle, clearance gauge body pass through the hinge, the clearance gauge handle on be provided with the first chamber of placing, the clearance gauge body pass through the position of hinge after folding with first position of placing the chamber corresponding. The utility model provides a clearance gauge body under the circumstances that the save was not good at, the problem of easy wearing and tearing.

Novel M3 muscarinic acetylcholine receptor antagonists

Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.

Locomotive iron shoe control system and control method

The invention provides a locomotive iron shoe control system and method, and relates to the technical field of railway control and communication networks, and the locomotive iron shoe control system comprises an iron shoe management device and an iron shoe control device; the iron shoe management equipment is arranged in a cab of the locomotive and comprises a first display unit, a first communication unit, an antenna unit, a main control unit and a first power supply module; wherein the main control unit is respectively in communication connection with the first display unit and the first communication unit, and the first communication unit is also in communication connection with the antenna unit; the iron shoe control equipment is arranged on each carriage of the locomotive and comprises a control unit, a second communication unit, a second power supply module, a mechanical arm control module and an iron shoe body; wherein the control unit is in communication connection with the second ...

A protection device for protecting concrete loading attachment separates lock -switch

The utility model discloses a protection device for protecting concrete loading attachment separates lock -switch has solved the finger pattern and separated the lock -switch unstable problem of working in the more environment of dust, and its technical scheme main points are: including box body and lid, install fingerprint sensor in the box body, still be provided with the dust removal subassembly in the box body, the dust removal subassembly is including changeing roller and drive it along the rotatory micro motor of self rotation axis, includes still that the cladding is in to change the roller change the silk on roller surface, the glass board of conflicting with the silk and scrape the dirt subassembly with the dust from what change that the roller surface strikes off, make the lock -switch of separating of this finger pattern can long -term steady job.

Acid-sensitive polymer containing beta-carboxyl amido bond as well as preparation method and application of acid-sensitive polymer

The invention belongs to the technical field of medical materials. A hydrophilic chain segment of the acid-sensitive responsive amphiphilic block polymer is polyethylene glycol, a hydrophobic chain segment of the acid-sensitive responsive amphiphilic block polymer is a homopolymer or copolymer based on a trimethylene carbonate derivative, side chain carboxyl of the hydrophobic chain segment is connected with a main chain through a beta-carboxyl amido bond, and the beta-carboxyl amido bond has the characteristics of being stable under neutral and alkaline conditions and capable of being used for preparing the acid-sensitive responsive amphiphilic block polymer. And the characteristic of fracture under a slightly acidic condition is achieved. A drug carrier prepared from the acid-sensitive responsive amphiphilic block polymer generates electrostatic attraction with an alkaline polypeptide/protein drug through carboxyl of a side chain of the polymer, and has excellent loading performance on ...

NOVEL M3 MUSCARINIC ACETYLCHOINE RECEPTOR ANTAGONISTS

Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.

Compounds

Five-membered heterocyclic amides wnt pathway inhibitor

Disclosed in the present invention is a five-membered heterocyclic amides Wnt pathway inhibitor, belonging to compounds that regulate the activities of a Wnt signaling pathway, and a method for preparing such compounds and use of such compounds in preparing drugs for antagonizing a Wnt signaling pathway are provided. The five-membered heterocyclic amides Wnt pathway inhibitor provided in the present invention has remarkable anti-tumor activities on the basis of a rational drug design for targets, and can be used in developing a new generation of Wnt pathway inhibitor, having a high clinical application value and a considerable market potential.

Split type crystallizer

The invention discloses a split type crystallizer. The split type crystallizer comprises two large surface walls, two small surface walls and a plurality of graphite flakes, wherein the larger surface walls and the small surface walls jointly form a crystal passage in a surrounding mode, and the graphite flakes are shaped like strips and vertically arranged on the inner wall of the crystal passage. According to the split type crystallizer, the graphite flakes are arranged on the inner wall of the crystal passage, and therefore the high temperature resistance is improved compared with a crystal passage with chrome plated on the inner wall, and the service life of the split type crystallizer is prolonged. In addition, the structure spliced by the multiple strip-shaped graphite flakes is adopted, damaged graphite flakes can be replaced conveniently, and therefore the maintenance cost of the split type crystallizer is lowered, and only the partial damaged graphite flakes are replaced rather ...

Astragalus membranaceus glycoprotein as well as preparation method and usage thereof

The invention discloses an astragalus membranaceus glycoprotein as well as a preparation method and a usage thereof. The astragalus membranaceus glycoprotein of the invention is prepared by the following steps: salting out in astragalus membranaceus water extract by utilizing ammonium sulfate; eliminating free proteins by utilizing a Sevage method; separating and purifying to prepare a new activecomponent by utilizing dialysis and DEAE-C32 anion exchange resin column chromatography; analyzing the new active component to obtain the astragalus membranaceus glycoprotein with the molecular weight of about 53.26kD by utilizing an SDS (Sodium Dodecyl Sulfonate)- polyacrylamide gel electrophoresis method; and further measuring through an experiment and verifying through a drug effect experimentthe physicochemical property of the new active component. The astragalus membranaceus glycoprotein of the invention has the advantages of obvious immunosuppression action and wide market prospects, and can ...

Hydraulic pressure dam

The utility model discloses a hydraulic pressure dam has rotatable dam body, still has: a disjunctor hinge base, wherein, the lower shaft of dam body bottom is rotationally installed on a disjunctor hinge base, install the main piston jar at the dam body back side, wherein, the jar seat of main piston jar is articulated with a disjunctor hinge base, and the piston rod of main piston jar is articulated with the dam body. The main piston jar exposes the installation, and through installing the main piston jar on a disjunctor hinge base, that realizes the main piston jar exposes the installation totally, not with dam foundation basic surface direct contact, avoids that the silt that the installation led to the fact in the ground foundation ditch pollutes, the phenomenon of sealing member accelerated ageing.

Automatic thumb wheel device

This embodiment provides an automatic thumb wheel device, belongs to filling equipment technical field. This automatic thumb wheel device is including entry wheel, export wheel and deflector, the deflector is provided with entry arc concave surface and export arc concave surface. Entry wheel is provided with a plurality of entry spacing grooves that are used for injecing the beverage bottle position along circumference is equidistant, the outer fringe of entry wheel with be provided with the access road that supplies the beverage bottle to pass through between the entry arc concave surface. Export wheel is provided with a plurality of export spacing grooves that are used for injecing the beverage bottle position along circumference is equidistant, the outer fringe of export wheel with be provided with the exit channel who supplies the beverage bottle to pass through between the export arc concave surface. Utilize above -mentioned automatic thumb wheel device, the liquid filling machine ...

Application of recyclable magnetic nanocapsule to dye adsorption

The invention discloses an application of a recyclable magnetic nanocapsule to dye adsorption and belongs to the technical field of nano material application. The application is characterized in that a hydrogen dioxide solution is adopted for performing oxidation treatment on the surface of the magnetic nanocapsule coated with carbon, so that the functional magnetic nanocapsule coated with the carbon is obtained, wherein the surface of the functional magnetic nanocapsule coated with the carbon contains oxygen-containing functional groups, and a dye solution is added for adsorption. After adsorption, magnetic separation is adopted, absolute ethyl alcohol is used for desorption, after desorption, magnetic separation is performed for collecting powder, the powder is further used for dye adsorption, and a cycle experiment is performed with an adsorption-magnetic separation-desorption being a period. The application has the advantages that the magnetic nanocapsule is easy to separate, desorption ...

Model driven layout design for robotics warehouse

Embodiments relate to the design of a (good-to-person) robotics warehouse, and in particular to a warehouse layout model. The warehouse layout model is interposed between a warehouse map/location model containing concrete physical location data (e.g., QR codes), and an overlying warehouse management system generally configured to interact with a robotics system. The warehouse layout model defines basic elements such as •rackspace, •rackspace block, •lane, and •workstation. Those elements may in turn be arranged into basic patterns such as •storage area, •workstation area, •entry area, and others. The layout model also includes a set of basic traveling rules governing the movement of robots in relation to the elements and patterns. The layout model serves as a translator between the generalized warehouse management system, and the location/map model specific to a particular warehouse footprint. The warehouse layout model facilitates adapting the robotic system to changes as the warehouse ...

Five-membered heterocyclic amides wnt pathway inhibitor

Disclosed in the present invention is a five-membered heterocyclic amides Wnt pathway inhibitor, belonging to compounds that regulate the activities of a Wnt signaling pathway, and a method for preparing such compounds and use of such compounds in preparing drugs for antagonizing a Wnt signaling pathway are provided. The five-membered heterocyclic amides Wnt pathway inhibitor provided in the present invention has remarkable anti-tumor activities on the basis of a rational drug design for targets, and can be used in developing a new generation of Wnt pathway inhibitor, having a high clinical application value and a considerable market potential.

Full -automatic PLC level check out test set that burns perpendicularly

The utility model discloses a full -automatic PLC level check out test set that burns perpendicularly, include: the box, measuring sample anchor clamps mechanisms (2), blowtorch mechanism (3) and the PLC control system that have workstation bottom plate (1), it includes to detect sample anchor clamps mechanisms (2): rotatable component, rotatable component at the bottom of divide a bottom card position, dividing the bottom card position and with the first branch of this rotatable component articulated, second branch, second branch quantity is more than two sets of or two sets of, the jib, jib quantity with second branch quantity is corresponding, is connected with second branch in proper order. The utility model discloses an equipment adopts multistation test fixture, and disposable location is experimental in proper order, disposable experimental finishing after the sample pretreatment of every group, the sample support is multi -functional and can conveniently adjust, changed equipment ...

Production method of quick-frozen Rhizoma polygonati chicken meal ball

The invention relates to a method for producing quick-frozen chicken meal balls by using broiler breast meat, and healthy Rhizoma polygonati which is commonly used and belongs to liliaceous plant, starch, pig fat, bone paste and other various seasonings. The finished product has good sensory quality and fresh taste, has effects of benefiting the spleen and stomach and supplementing body essence and marrow, and is characterized in that the meal balls are nutritive and healthy and convenient to eat.

Digit printing processing method of cashmere product

The present invention relates to a digital printing processing method for cashmere products, which comprises the following steps: scanning a garment blank to manufacture a mould, pattern processing, color calibration, placing the pattern simulation to be printed at a requested position by the mould with a computer software, extending and filling the garment blank according to the mould, anti-scanning the garment blank extended and filled according to the mould, checking the printing position of the pattern to be printed at the garment blank with a computer software, digital printing, drying apre-steaming garment blank, steaming, washing using water, drying, slopwork and finishing. Said method is characterized in that: a pretreatment process is set before scanning a garment blank to manufacture a mould, wherein the prescription of the pretreatment solution is that there contains, based on the weight, an adhesion additive of 2-5%, a printing oil of 2-3%, a brightening agent of 2-3%, a paste ...

Automatic emptying frame for reinforcing steel bar coiling and straightening

The utility model provides an automatic emptying frame for reinforcing steel bar coil straightening. The automatic emptying frame for steel bar wire rod circle straightening comprises a concentric-square-shaped ground placing plate, the plurality of transverse connecting rods I are fixedly mounted on the concentric-square-shaped ground placing plate; the concave motor placing seat is arranged in the concentric-square-shaped ground placing plate, and one end of the first transverse connecting rod is fixedly connected with the concave motor placing seat; the driving motor is fixedly mounted on the concave motor placing seat; the circular rotating plate is arranged above the concentric-square-shaped ground placing plate; circular ring type fixed connecting block. The automatic unwinding frame for steel bar coiling and straightening has the advantages of being convenient to use, capable of winding and unwinding steel bars according to needs, capable of adjusting the second strip-shaped placing ...

Fusion embedded unit and fusion terminal

The invention provides a fusion embedded unit and a fusion terminal, the fusion embedded unit is applied to the fusion terminal, and the fusion embedded unit comprises a 5G module, a 2.4 G downlink communication unit, an interface unit, an antenna unit and a control unit; the 5G module and the 2.4 G downlink communication unit are respectively connected with the antenna unit; a first interface in the interface unit, the 5G module and the 2.4 G downlink communication unit are respectively connected with the control unit, and the 5G module and the 2.4 G downlink communication unit are respectively connected with a second interface in the interface unit. According to the invention, the intelligent fusion terminal does not need to be transformed, so that the manufacturing cost is reduced; therefore, the intelligent fusion terminal has 5G communication and 2.4 G wireless communication capabilities at the same time, and normal return of power business data is ensured.

Method, device and equipment for adjusting opening degree of gate

The invention provides a gate opening degree adjusting method, device and equipment. The method comprises the steps of obtaining water conservancy data of a target hydropower station; determining a flow value of the target hydropower station according to flow velocity data in the water conservancy data; if a difference value between the flow value and a preset flow value is determined to be greater than or equal to a first preset threshold value, inputting the flow value into a preset prediction model to obtain a predicted flow value; and adjusting the gate opening degree of the gate of the target hydropower station according to the predicted flow value. According to the method, the water flow data of the current target hydropower station can be predicted, and the gate opening degree of the hydropower station gate is dynamically adjusted according to the predicted water flow, so that the aim of intelligently transporting the hydropower station is fulfilled, and the operation and maintenance ...

Biaryl urea derivative or salt thereof and preparation process and use for the same

The present invention discloses a biaryl urea RORγt inhibitor, and specifically relates to a biaryl urea derivative, as represented by formula I, with an RORγt inhibiting activity, and a preparation process thereof, and a pharmaceutical composition comprising the compound. Further disclosed is use of the compound for treating an RORγt-related disease.

BIARYL COMPOUND, PREPARATION METHOD AND USE THEREOF

The present invention belongs to the technical field of chemical pharmaceuticals, and relates to a compound represented by general formula (I) or formula (II) and a preparation method thereof. The compounds are biaryl derivatives with RORγt activation activity. The biaryl derivatives disclosed in this invention can effectively activate the RORγt protein receptor, and thereby promote the differentiation of Th17 cells and increasing the production of IL-17, which can be used as an immune modulator for the treatment of various cancers or viral infection-related diseases.

Subdivision formula NBG class gas tightness bulkhead stuffing box test device

The utility model relates to a subdivision formula NBG class gas tightness bulkhead stuffing box test device, including simulation compartment, compartment support, dummy shaft and gravity oil tank, wherein: the compartment support that is equipped with the strengthening rib is located simulation compartment bottom, be equipped with the sealed chamber of detecting on the simulation compartment, the dummy shaft is located sealed opening one side of detecting the chamber, and simulation compartment one side is equipped with the simulation compartment and supports. The support of simulation compartment, sealed detection chamber and dummy shaft are located same axis, be furnished with clamp ring on the dummy shaft, the tip of dummy shaft is furnished with drive arrangement, the gravity oil tank is located the top of dummy shaft, and their difference in height is 0.3 -2.1 rice, and gravity oil tank bottom is equipped with and is surveyed the play oil pipe that packing box oiling mouth docked ...

Network element parameter configuration and error self-recovery method for use in wireless communication system

The invention relates to a network element parameter configuration method for use in a wireless communication system. The method comprises the following steps: recording configuration parameters in a database; generating unique index values of the parameters by using the database; configuring network elements in parallel or in series by a configuration initiator; and unifying configuration interfaces as operation types and the unique index values of the parameters in the database. Through use of the scheme of the invention, the problems of sequence limitation on signaling flows, complex exception handling flows and the like during the establishment, modification and deletion of channels are solved.

Preparation method of waste steel aluminum-based silicon carbide

The invention discloses a preparation method of waste steel aluminum-based silicon carbide, and belongs to the field of aluminum-based composites.The waste steel, 7075 aluminum alloy powder and modified silicon carbide powder are used as raw materials, and the waste steel aluminum-based silicon carbide is fired in a vacuum hot pressing sintering mode. Waste steel is cut, a steel flat bar is prepared to reinforce and toughen an aluminum-based silicon carbide material, the extrusion force and shear force of cutting the waste steel can carry out deformation and dislocation strengthening on the invalid steel, and the performance of the steel is continuously strengthened on the basis of the existing strength; the modified silicon carbide can enhance the wettability and bonding strength with the aluminum powder matrix. The aluminum-based composite material has the advantages that the mechanical property of the aluminum-based composite material is good, subsequent deformation cold and heat treatment ...

FIVE-MEMBERED HETEROCYCLIC AMIDES WNT PATHWAY INHIBITOR

The present invention discloses a five-membered heterocyclic amide WNT pathway inhibitor, which belongs to a compound that regulates the activity of a Wnt signaling pathway, and provides a method for preparing such a compound, and the use of such a compound in preparing a medicament that antagonizes the Wnt signaling pathway. The five-membered heterocyclic amide WNT pathway inhibitor provided by the invention has a remarkable anti-tumor activity based on a target-based rational drug design of, and can be used for the development of a new generation of Wnt pathway inhibitors, and has a great clinical application value and considerable market potential. 7. The five-membered heterocyclic amide Wnt pathway inhibitor according to claim 1 , wherein the aryl group is a phenyl claim 1 , naphthyl or anthryl group; the heterocyclyl group is a morpholinyl claim 1 , piperidyl claim 1 , pyridyl claim 1 , pyrimidinyl claim 1 , pyranyl claim 1 , thienyl claim 1 , furyl claim 1 , pyrrolyl claim 1 , pyrazolyl claim 1 , imidazolyl or thiazolyl group; and the halogen is selected from one of a group consisting of fluorine claim 1 , chlorine claim 1 , bromine and iodine.8. A five-membered heterocyclic amide Wnt pathway inhibitor claim 1 , selected from the following: N-((2′ claim 1 ,3-dimethyl-[2 claim 1 ,4′-bipyridin]-5-yl)methyl)-1-methyl-3-phenyl-1H-pyrazole-5-carboxamide;N-((2′,3-dimethyl-[2,4′-bipyridin]-5-yl)methyl)-5-phenyl-1H-pyrazole-3-carboxamide;N-((2′,3-dimethyl-[2,4′-bipyridin]-5-yl)methyl)-2-phenylthiazole-5-carboxamide;N-((2′,3-dimethyl-[2,4′-bipyridin]-5-yl)methyl)-5-phenylthiazole-2-carboxamide;N-((2′,3-dimethyl-[2,4′-bipyridin]-5-yl)methyl)-2-phenylthiazole-4-carboxamide;N-((2′,3-dimethyl-[2,4′-bipyridin]-5-yl)methyl)-4-phenylthiazole-2-carboxamide;N-((2′,3-dimethyl-[2,4′-bipyridin]-5-yl)methyl)-5-phenylisoxazole-3-carboxamide;N-((2′,3-dimethyl-[2,4′-bipyridin]-5-yl)methyl)-5-phenyl-1,3,4-thiadiazole-2-carboxamide;N-((2′,3-dimethyl-[2,4′-bipyridin]-5-yl)methyl)-1- ...

COMMUNICATION METHOD AND APPARATUS, AND ELECTRONIC DEVICE AND PROGRAM PRODUCT THEREOF

The present application provides a communication method and apparatus, and an electronic device and program product thereof. The method includes: acquiring a communication request of a first virtual machine application, packaging the communication request on a second virtual machine, and sending the packaged communication request to a communication component; and/or receiving communication data sent by a communication component, parsing the communication data on a second virtual machine, and sending the parsed communication data to a first virtual machine application. According to the present application, on the basis that a connection is established between the second virtual machine and the communication component, a connection between the first virtual machine and the communication component may be also established via the second virtual machine, further the first virtual machine may implement communication directly based on the connection relationship when necessary.

Intelligent tablet computer telephone system based on WIFI (Wireless Fidelity)

The invention provides an intelligent tablet computer telephone system based on WIFI (Wireless Fidelity). The intelligent tablet computer telephone system comprises a PSTN (Public Switched Telephone Network) base which comprises a PSTN telephone channel unit, a first voice A/D (Analog to Digital) conversion unit, a first main control unit and a WIFI wireless routing unit, and a tablet computer which comprises a WIFI wireless receiving/transmitting unit, a second main control unit, a second voice A/D conversion unit, a voice input/output unit and a user input/output interaction unit, wherein the WIFI wireless routing unit of the PSTN base is in WIFI wireless communication connection with the wireless receiving/transmitting unit of the tablet computer; the tablet computer is used for providing an input interface for user telephone operation; and the PSTN base is used for executing a telephone operation request input into the tablet computer. As a brand new PSTN telephone system, a conventional ...

A sweeping structure for dust collection device

The utility model discloses a sweeping structure for dust collection device has solved and has carried out the in -process collected through collecting bag to the dust, and the dust adsorbs in collecting bag easily in the stopper of the line seal lock on the dust sucking bag, has reduced collecting bag filtration efficiency's problem, and its technical scheme main points are: including collectingbag, still include a ring tooth, first gear and motor, a ring tooth and collecting bag cup joint, first gear and ring tooth meshing, the motor is connected with first gear drive, the preforming that aring tooth inner wall fixedly connected with and collecting bag conflicted, a ring tooth terminal surface is equipped with the ring channel along its self circumferencial direction, and swing joint has solid fixed ring in the ring channel, and a solid fixed ring terminal surface fixedly connected with is used for supporting solid fixed ring's connecting rod, has improvement collecting bag filtration ...

Method and Device for Displaying Application Image

A method and a device for displaying an application image are provided, and the method includes the following steps: receiving a display request from a second operating system, and reading the application image stored in a storage area; judging whether it is required to process the application image through a window manager according to the configuration of the local image display system, and if required, sending the application image to the window manager, and sending the application image processed by the window manager to a display graphics library for processing; if not, directly sending the application image to the display graphics library for processing; and acquiring the location of the display memory through a display driver, sending the application image processed by the display graphics library to the display memory, and displaying the application image through the display memory. Using the solution, the application image of the installable operating system can be displayed in the local operating system. 1. A method for displaying an application image , which is applicable in a device comprising a first operating system and a second operating system with the first operating system comprising a memory comprising a storage area assigned to the application of the second operating system and which comprises:receiving a display request from the second operating system and reading the application image stored in the storage area;judging whether a window manager is needed to process the application image according to the configuration of a local image display system, and if the window manager is needed, transmitting the application image to the window manager and transmitting the application image processed by the window manager to a display graphic library for processing; otherwise, transmitting the application image directly to the display graphic library for processing; andacquiring the location of a frame buffer through a display driver, transmitting the ...

BENZOFURAN PYRAZOLE AMINE KINASE INHIBITOR

The present invention discloses a compound for regulating protein kinase activity and used for treating or preventing diseases associated with protein kinases. Specifically, the present invention relates to a benzofuran pyrazole amine protein kinase inhibitor which belongs to compounds that regulate anaplastic lymphoma kinase (ALK), and provides a method of preparing such a compound and a pharmaceutical use of such a compound in the treatment or prevention of diseases associated with ALK. The inhibitor can solve the problem of the drug resistance of the first generation and the second generation of ALK inhibitors. 7. The benzofuran pyrazolamines protein kinase inhibitor according to claim 1 , wherein the aryl is phenyl claim 1 , naphthyl or anthryl; the heterocyclyl is morpholinyl claim 1 , piperidyl claim 1 , pyranyl claim 1 , pyrazolyl claim 1 , furyl claim 1 , pyridyl or pyrimidinyl; and the halogen is selected from one or more of the group consisting of fluorine claim 1 , chlorine claim 1 , bromine and iodine.8. A benzofuran pyrazolamines protein kinase inhibitor selected from the following compounds:{'sup': 2', '4, '(R)-5-chloro-N-(2,5-dimethyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-N-(3-(isopropylsulfonyl)-1-methyl-1H-pyrazol-4-yl)pyrimidine-2,4-diamine;'}{'sup': 2', '4, '(R)-5-chloro-N-(2,5-dimethyl-4-(1-methylpiperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-N-(3-(isopropylsulfonyl)-1-methyl-1H-pyrazol-4-yl)pyrimidine-2,4-diamine;'}{'sup': '4', '(R)—N2-(2,5-dimethyl-4-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-N-(3-(isopropylsulfonyl)-1-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;'}{'sup': 2', '4, '(R)—N-(2,5-dimethyl-4-(1-methylpiperidin-4-yl)-2,3-dihydrobenzofuran-7-yl)-N-(3-(isopropylsulfonyl)-1-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)pyrimidine-2,4-diamine;'}(R)-2-(4-(7-((4-((3-(isopropylsulfonyl)-1-methyl-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2,5-dimethyl-2,3-dihydrobenzofuran-4-yl)piperidin-1-yl) ...

Water-soluble fertilizer by complexing humic acid with plurality of nutrient elements and preparation method thereof

The invention belongs to the technical field of agriculture, in particular relates to a water-soluble fertilizer by complexing humic acid with a plurality of nutrient elements and a preparation method thereof. The water-soluble fertilizer is prepared by complexing the following raw materials by weight parts: 8 parts of potassium humic acid powder containing more than or equal to 50 percent of humic acid component, more than or equal to 10 percent of potassium oxide component and less than or equal to 2 percent of water-insoluble substances, 42-46 parts of water, 33-38 parts of major element compound, 10 parts of trace element compound, 1.3-1.5 parts of additives and 1.8-2.5 parts of plant growth regulator. The preparation method comprises six steps. The water-soluble fertilizer has the advantages of complete nutrient elements, higher crop absorption utilization rate and stronger directivity.

Flexible supporting method of large-aperture lens

The invention discloses a flexible supporting method of a large-aperture lens, which comprises the steps of; firstly, machining three bosses on the excircle of a circular lens base with a certain thickness at intervals of 120 DEG , machining a connecting part with a cuboid structure on the outer side of each boss, machining an installing hole and a pin hole on the outer side of each boss along the radial direction of the lens base, machining an installing hole and a pin hole on the connecting part along the axial direction of the lens base, machining an installing hole on each boss along the axial direction of the lens base, and machining a small boss with a step on the inner side of each boss; secondly, machining three corresponding installing surfaces on the excircle of the lens at intervals of 120 DEG, and machining radial flexible elements and axial press plates; thirdly, bonding the radial flexible elements with the lens, and fixing the bonded assembly in the lens base through the ...

Self -discharging van -type mine car

The utility model discloses a self -discharging van -type mine car, including tramway, vehicle wheel to, body frame and mine car carriage, the both sides that the mine car carriage is located the direction of motion are lifting side and discharge side respectively, the mine car carriage the discharge side is provided with the baffle of unloading, the mine car carriage the discharge side bottom still is provided with and is on a parallel with the trip shaft of tramway, the mine car carriage passes through the trip shaft with the top surface of body frame is connected, the mine car carriage the lifting side is provided with the lifting stabilizer blade, the bottom of lifting stabilizer blade is provided with the perpendicular to the lifting running roller of tramway, still including being on a parallel with the guide rail of unloading of tramway setting, being provided with of guide rail of unloading has the lifting top surface of domatic structure, the lifting running roller place in on ...

Bearer with built-in part and its making method

The invention discloses a loader with an embedded element and a method for manufacturing the same. The loader with an embedded element comprises a substrate and at least one embedded element, the substrate is provided with at least a groove hole and a first composite layer, the embedded element is arranged in the groove hole of the substrate, the first composite layer is provided with an exhausting structure, at least a first through hole and at least a fixation piece, wherein the exhausting structure is corresponding to the groove hole, the embedded element is exposed out of the first throughhole, the first fixation piece is formed in the first through hole and can contact the embedded element. The loader with an embedded element can make steam inside the loader under a high temperatureenvironment exhaust outside by the exhausting structure, and can increase the combination strength between the embedded element and the substrate by the first fixation piece contacting the embedded element ...

Built-in capacity cell structure and method for producing same

The present invention relates to a buried capacitive component structure and a manufacturing method of the buried capacitive component structure. The buried capacitive component structure comprises adielectric layer, a first conducting layer, a second conducting layer, a first panel and a second panel, wherein, the dielectric layer is provided with a thickness. The first conducting layer is positioned on the one side of the dielectric layer, and provided with a first electrical property. The second conducting layer is positioned on the other side of the dielectric layer relative to the firstconducting layer, and provided with a second electrical property. The first panel is inserted in the middle of the dielectric layer, and electrically connected with the first conducting layer. The second panel is inserted in the middle of the dielectric layer, and electrically connected with the second conducting layer, and away from a certain distance with the first panel.

Vehicle carrying plate ascending limiting device for stereo garage

The utility model relates to a vehicle carrying plate ascending limiting device for a stereo garage. Mounting plate, a first mounting seat and a second mounting seat are respectively arranged on the mounting plate; the second mounting base is positioned below the first mounting base; the first mounting base and the second mounting base are detachably connected with the mounting plate; meanwhile, afirst travel switch is further mounted on the first mounting base; a second travel switch is further mounted on the second mounting seat; the device further comprises a collision block mechanism installed on the vehicle carrying plate, the collision block mechanism comprises a horizontally-arranged bottom plate, a vertically-arranged vertical plate and an obliquely-arranged collision plate, the bottom plate is detachably connected with the vehicle carrying plate, the bottom end of the vertical plate is connected with the bottom plate, and the top end of the vertical plate is connected with the ...

Mortar consistency tester of centre gripping formula slide bar

The utility model discloses a mortar consistency tester of centre gripping formula slide bar, including slide bar and support, it is connected with the horizontal pole to slide on the support, and theone end that the support was kept away from to the horizontal pole is slided and is connected with the slide bar that is vertical state, the one end that the support was kept away from to the horizontal pole is equipped with the clamping part, and the clamping part includes grip block and spring that two pairs of symmetries set up, and the one end of grip block is located to the spring, and underthe spring natural state, the one end that the spring was kept away from with the grip block to the spring is contradicted in the side of slide bar, be equipped with separately the opening part of slide bar and grip block on the horizontal pole, the experimenter when the clamping block pole, use opening part two grip blocks separately to make leave among them can the clamping block pole the space, the ...

Sea sand chlorine ion content detection device

The utility model discloses a sea sand chlorine ion content detection device has solved and has utilized among the prior art precipitation titration to examine time measuring to extra large sand chlorine ion content, and the operator is easy because judge inaccurately and there is the technical problem of great error in extra large sand chlorine ion content that lead to detecting to the precipitate colour, and its technical scheme main points are: include: examine test table, mixing tank sets up examine on the test table for mix extra large sand and deionized water, reaction vessel sets up onexamining test table, with the mixing tank intercommunication is used for receiving the aqueous solution of the chlorion of formation in the mixing tank, the colorimetric card sets up examine on the test table for it compares to carry out the colour with the precipitate of formation in the reaction vessel, through setting up the colorimetric card as the object of reference, opportunity that the operator ...

High-strength fireproof door and preparation method thereof

The invention relates to the technical field of fireproof door preparation, in particular to a high-strength fireproof door and a preparation method thereof. The preparation method of the high-strength fireproof door comprises the following steps of continuous casting of molten steel to form a blank, rough rolling and finish rolling, water flow injection and air injection cooling alkali washing, preparation of a fireproof door plate through annealing shearing, preparation of a fireproof filling core material, gluing and edge sealing inspection. The door plate of the fireproof door is prepared from the cold-rolled steel plate, the strength and hardness of the cold-rolled steel plate are improved, the cold-rolled steel plate is more heat-resistant than a hot-rolled steel plate, and the air injection device is used for uniformly spraying laminar cooling water flow on the steel plate in the preparation process, so that the temperature of each part of the steel plate is uniform, uneven heating ...

System and process for recovering nickel from nickel plating wastewater

The invention relates to a nickel-plating wastewater nickel recovery system and process, and belongs to the technical field of heavy metal ion electroplating wastewater treatment.The nickel-plating wastewater nickel recovery system comprises a concentration device and an electrolysis device.The concentration device comprises a collection pool, a multi-stage membrane system and a reverse osmosis system, and the collection pool is used for conveying wastewater into the multi-stage membrane system; the multi-stage membrane system is used for intercepting nickel ions in the wastewater and concentrating step by step, the multi-stage membrane system is used for producing concentrated water and produced water, the electrolysis device is used for electrolyzing the concentrated water to recover nickel metal, and the reverse osmosis system is used for recovering the produced water. The nickel ion recovery device has the advantages that the nickel ion recovery rate and recovery efficiency are improved ...

Foldable hanging type protection structure

The invention belongs to the technical field of protection and provides a foldable hanging type protection structure. The foldable hanging type protection structure is provided with a flexible base material (1) which covers the surface of a protected target completely in the tangential direction, wherein multiple flat protection plates (2) are arranged on the flexible base material in sequence in the tangential direction of the protected target, and the multiple flat protection plates (2) are in lap joint to form an integral structure used for seamless protection of the protected target. According to the foldable hanging type protection structure, seamless protection of a curved-surface type protected target is realized, the flexible hinge type design enables the multiple flat protection plates to be folded to form a stereo blocky vertically-stacked structure, modular folding packaging is realized, and installation and transportation are facilitated.

Two -way hydraulic pressure of combined type plays to rise dam

The utility model discloses a two -way hydraulic pressure of combined type plays to rise dam has: hydraulic means, pivot and dam body, dam body fixed mounting are in the pivot, and the pivot is rotationally installed on the bearing frame, and through setting up first piston rod into hollow structure, the second piston rod stretches into in the through -hole of first piston rod and can slide in the through -hole, the one end and second piston rod packing of cylinder bobbin base are kept away from to the second piston rod, the second piston rod is connected with the dam body, with the oil circuit that fuel feeding mechanism is connected, the oil circuit respectively is equipped with an oil pipe and has let in pole chamber and nos pole chamber, hinders and also can put the dam smoothly and fall dam, low in manufacturing cost, processing conveniently even receive the debris card.

Preparation of 6-substituted-4-chromanone-2-carboxylic acid

The invention discloses a method for preparing a 6-substituted-4-chromanone-2-methanoic acid. The method uses phenol or derivatives thereof, and maleic anhydride as raw materials. The method comprises the following steps: 1) phenol esterification, in which, the phenol or the derivatives thereof react with the maleic anhydride under base catalysis; 2) carboxyl esterification, in which, 3-(4-substituted phenyl)-3-keto-2-crotonic acid is dissolved in an organic solvent I, and an esterification catalyst and ethanol are added to the mixed solvent to react; 3) Fries recomposition, in which, the 3-(4-substituted phenyl)-3-keto-2-crotonic acid and aluminum trichloride are mixed to react; and 4) Michael addition, in which, the 3-(4-substituted phenyl)-3-keto-2-crotonic acid reacts with a sodium bicarbonate solution. The method for preparing the 6-substituted-4-chromanone-2-methanoic acid has the characteristics of simple and safe operation and low production cost.

M3 muscarinic acetylcholine receptor antagonists

Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.

Remote control system and method and storage medium

The invention provides a remote control system and method and a storage medium, the remote control system comprises a control device, a controlled device, and a 5G channel and an optical fiber channel connecting the control device and the controlled device, specifically, the controlled device determines a service type of a to-be-sent service corresponding to a first service sending request in response to the first service sending request, and sends the to-be-sent service to the control device; and monitoring first performance data of an optical fiber channel and second performance data of a 5G channel under the condition of transmitting data to the control equipment based on the service type, determining a first target channel used for transmitting the to-be-transmitted service according to the two kinds of data, and transmitting the to-be-transmitted service to the control equipment through the first target channel. In the technical scheme, the 5G channel and the optical fiber channel ...

Large diameter expansible primary lens precision locking apparatus for spatial observation optical remote sensor

Vehicle over-limit overload and environment monitoring system

The invention belongs to the technical field of urban road and environment monitoring equipment, and particularly relates to a vehicle over-limit overload and environment monitoring system which comprises a first support, a second support and a third support. A first ground induction coil and a second ground induction coil are arranged on the two sides, in the vehicle advancing direction, of the quartz weighing sensor respectively, the first ground induction coil, the second ground induction coil and the quartz weighing sensor are connected with a first industrial personal computer case, and an environment monitoring box is arranged on the third support. The environment monitoring box is connected with a second industrial personal computer case arranged on the third support, snapshot cameras are arranged on the first support, the second support and the third support, the snapshot cameras are connected with a third industrial personal computer case, and the first industrial personal computer ...

Process design task driving and loop closing method based on PBOM

The invention provides a PBOM-based process design task driving and closed-loop method, which enables the whole process of process preparation work including PBOM creation, process route compiling, various process procedure compiling, various summary sheet completion and the like to be carried out in a task closed-loop mode, and ensures that a process file is complete through integrity check. Finally, the task creator completes task closing, a complete process file closed-loop link from the initiating end to the executing end is achieved, and the task monitoring rate is achieved.

METHOD AND APPARATUS FOR SIMULTANEOUSLY RUNNING MULTIPLE VIRTUAL MACHINES, AND ELECTRONIC DEVICE

The present invention provides a method and apparatus for simultaneously running multiple virtual machines, and an electronic device. The method includes: initiating a request of running a second operating system in Qemu; triggering abnormality to a Hypervisor of a currently running first operating system in a KVM module; storing a context of the Hypervisor of the first operating system in the Hypervisor of the first operating system, and loading the context of the Hypervisor of the second operating system; and storing the context of the first operating system in the Hypervisor of the second operating system, and loading the context of the second operating system. By adoption of the solution provided by the present application, multiple virtual machines can be run simultaneously, and the respective functions can be run independently. 1. A method for simultaneously running multiple virtual machines , comprising:initiating a request of running a second operating system in Qemu;triggering abnormality to a Hypervisor of a currently running first operating system in a KVM module;storing a context of the Hypervisor of the first operating system in the Hypervisor of the first operating system, and loading the context of the Hypervisor of the second operating system; andstoring the context of the first operating system in the Hypervisor of the second operating system, and loading the context of the second operating system.2. The method according to claim 1 , further comprising:when the termination of the running of the second operating system is monitored in the Qemu, storing the context of the second operating system in the Hypervisor of the second operating system, and loading the context of the first operating system;triggering abnormality to the Hypervisor of the second operating system in the KVM module; andstoring the context of the Hypervisor of the second operating system in the Hypervisor of the second operating system, and loading the context of the Hypervisor of ...

Transparent parallel board device for researching fracture acidizing fluid viscous

The invention relates to a transparent parallel plate device for researching the viscous fingering of fractured acidification fluid, which is utilized for the test and research for the viscous fingering of fractured acidification construction in an oil field. The transparent parallel plate is characterized in that the transparent parallel plate is composed of two transparent plates which are bonded at the four edges, and a stimulant slit with the width between 5 mm and 20 mm is formed between the two parallel plates. A pressure sensor is fixed on one side of the parallel plates. A release valve and an exhaust valve are fixed on the parallel plates, and an inlet and an outlet for testing fluid are arranged on the left end face and the right end face. The outlet of a pumping system is connected with the inlet of two intermediate containers. A piston or a diaphragm is arranged inside an intermediate container. The outlet of the intermediate container is connected with the inlet of a shunt.

Supporting structure of arc hydraulic pressure plays to rise dam

The utility model discloses a supporting structure of arc hydraulic pressure plays to rise dam has: upper end and dam body articulated supporting pole, raise, when the supporting pole supports the dam body, be used for the supporting when the dam body the bearing of lower extreme of supporting pole wherein, is equipped with the locating hole of locating support pole lower extreme on the bearing, in telescoping cylinder, the piston rod of telescoping cylinder stretch into the locating hole of bearing, and the lower extreme that can will support the pole release the locating hole, when the dam body goes up and down, along supporting the setting of pole lower extreme direction of motion, accepting the slide rail that supports the pole lower extreme and slide, will support the pole through the telescoping cylinder and release the bearing, the independent control supports the release of pole, and the release of supporting pole is reliable and stable, ensures the safety of dam body.

Eyesight protection device, eyesight protection system and monitoring method of eyesight protection device

The invention provides an eyesight protection device, an eyesight protection system and a monitoring method of the eyesight protection device, belongs to the technical field of communication, and can solve some problems in the prior art. The invention provides an eyesight protection device. The eyesight protection device comprises a millimeter wave radar monitoring module, a control module and a prompt module, wherein the millimeter wave radar monitoring module is configured to monitor the distance between a user and a reading material watched by the user; the control module is configured to generate a first control signal at least when it is judged that the distance monitored by the millimeter wave radar monitoring module is smaller than a first preset value; and the prompting module is configured to respond to the first control signal and send out a prompting signal.

COMMUNICATION IMPLEMENTATION METHOD, CENTRAL PROCESSING UNIT AND TERMINAL

A method for implementing communication includes: determining an operating system corresponding to a current time slice, the determined operating system supporting a communication network standard; determining a memory partition; running the determined operating system based on the determined memory partition and driving a Digital Signal Processor, a signal processing module supporting the communication network standard and a Radio Frequency signal transceiver based on a hardware driving program included in a system program of the determined operating system; controlling the signal processing module to read authentication information of the terminal and controlling the Digital Signal Processor to encapsulate, based on a communication protocol, the authentication information of the terminal to generate a communication network signal; and controlling the Radio Frequency signal transceiver to convert the communication network signal into a Radio Frequency signal and send the Radio Frequency signal to a communication network.

REPAIRING APPARATUS FOR REMOVAL OF METAL RESIDUALS ON DISPLAY SUBSTRATE

A repairing apparatus for removal of metal residuals on a display substrate is provided. The apparatus includes a storage container, comprising at least a first container configured to store a metal etchant; an adsorption component, configured to be adsorbed on a surface to be repaired on the display substrate and to cooperate with the surface to be repaired to define collectively a closed chamber therebetween; and a circulating pipe assembly, arranged to be connected and in fluid communication between the storage container and the adsorption component. The repairing apparatus may include a first fluid circuit arranged to be connected and in fluid communication between the first container and the adsorption component and configured to guide the metal etchant within the first container to flow to the adsorption component and into the chamber and then back into the first container.

Environment-friendly aerosol and preparation method thereof

The invention discloses an environment-friendly aerosol and a preparation method thereof. The aerosol is prepared from the following raw materials in percentage by weight: 0.1-3.5% of diclofenac sodium or lidocaine and chlorhexidine acetate, 0.05-17.5% of a percutaneous absorbent, 40-80% of a solvent and 15-45% of a propellant, wherein the propellant is dimethyl ether. The preparation method comprises the following steps: dissolving diclofenac sodium or lidocaine and chlorhexidine acetate in ethanol to obtain a diclofenac sodium solution or an ethanol solution containing lidocaine and chlorhexidine acetate; adding the percutaneous absorbent and the solvent into the diclofenac sodium solution or the ethanol solution containing lidocaine and chlorhexidine acetate to obtain a chemical solution; and injecting the chemical solution into a filling container, then sealing, injecting the propellant, and pressing to cover the container. The aerosol prepared by the method disclosed by the invention ...

Mobilizable fog room of cement maintaining shelf

The utility model discloses a mobilizable fog room of cement maintaining shelf, including the room body and the internal support in room, room body bottom is equipped with the guide slot that is parallel to each other, what be equipped with on the support that the multilayer is used for placing cement test block puts the thing board, the support bottom is equipped with rolling gyro wheel in the guide slot, the both sides face that the support is relative is equipped with the portion of gripping, placed cement test block on putting the thing board after, operating personnel pushes away movablesupport and slides along the guide slot through holding the portion of gripping, slides in the support on the guide slot in proper order, after the cement test block maintenance was accomplished, it could to pull out the guide slot with the support in proper order. Above -mentioned operation can be practiced thrift and left the space that supplies operating personnel transport cement test block between ...

Method for cultivating cotton on saline and alkaline lands

The invention discloses a method for cultivating cotton on saline and alkaline lands. The method sequentially includes steps of preparing lands; applying fertilizers to the lands; forming a plurality of seed sowing furrows; digging holes in the seed sowing furrows; sowing seeds in each hole; covering the seed sowing furrows by the aid of mulching films; releasing seedlings; performing top dressing and chemical control; pruning and performing topping; piling up soil on two sides of each mulching film after the mulching film covers the corresponding seed sowing furrows, and arranging side ridges on the two sides of each mulching film. The method for cultivating the cotton in the saline and alkaline lands has the advantages that the soil on the two sides of each mulching film is piled up, the corresponding side ridges are arranged on the two sides of each mulching film, salt in the soil can be gathered on the surfaces of the side ridges from the bottoms of the side ridges along the side ridges ...

Automatic frequency conveerting method for unidirectional wireless receiver

The method makes wireless receiver possible to connect to wireless peripheral equipment online to receive signal transferred from wireless peripheral in one way, and the signal is transferred to the connected host. When receiving signal of indicating that wireless peripheral equipment is interfered, the wireless receiver transfers a prompt for reminding of user to change channel for the identification code to the host to be displayed on screen, in order to prompt user to change channel for the identification code of the wireless peripheral equipment. Then, the method tests channel replaced by the wireless peripheral equipment, and changes channel for the identification code to a channel identical to the channel replaced by the wireless peripheral equipment. Thus, in automatic mode for changing channel, the wireless receiver can keep touch with wireless peripheral equipment online muchly without bother of changing channel frequently.

Method for producing methane through mixed slaking of straw stalks subjected to alkali treatment and surplus sludge

The invention discloses a method for producing methane through the mixed slaking of straw stalks subjected to alkali treatment and surplus sludge, and belongs to the technical field of solid waste disposal control and environment-friendly purification treatment. According to the invention, the mixed anaerobic fermentation is adopted to produce methane, the harmless disposal and resource utilization of wastes are realized while the straw stalks and surplus sludge are effectively treated, the system is stable in operation, the energy recovery rate is high, and a better treatment effect is achieved in the situation that the raw material sources are complex.

System and method for input tool invocation and proxy device

A system and a method for input tool invocation and a proxy device enable an installable operating system to perform input operation by invoking the input tool of a local operating system, such as a soft keyboard of the local operating system, an input method of the local operating system, or a soft keyboard and an input method of the local operating system. Even an operating system not installed with input tools can perform input operation by invoking an input tool of a local operating system, thereby avoiding repeated installations of input tools for different operating systems, and resolving the issue of large resource usage caused by repetitive installations of input tools.

Robot control system for minimizing a number of racks used for order picking

Techniques are provided for controlling an order-picking, rack-transporting robot. More specifically, the robot is controlled to select a minimized number of movable racks storing ordered products identified in one or more orders for product deliveries, while still ensuring that all ordered products are included.

Self-service vending device control method

A method for controlling a self-service vending device to be safely opened, a server and a self-service vending system are provided. The method comprises: acquiring first position information of a mobile terminal when it is detected that the mobile terminal requests the self-service vending device to be opened by scanning two-dimensional code information on the self-service vending device, and acquiring identifier information of the self-service vending device according to the two-dimensional code information (101); querying a preset database according to the identifier information of the self-service vending device, and acquiring second position information corresponding to the self-service vending device (102); and calculating a distance between the mobile terminal and the self-service vending device according to the first position information and the second position information, and determining whether the distance is within a preset safe distance range (103); and when the distance is within the preset safe distance range, controlling the self-service vending device to be opened (103a). Through the method, it can be determined whether a code scanning-based cabinet opening action of a user is a real action of the user, so as to improve the safety of the user's property.

BIARYL UREA DERIVATIVE OR SALT THEREOF AND PREPARATION PROCESS AND USE FOR THE SAME

The present disclosure discloses a biaryl urea RORγt inhibitor, and specifically relates to a biaryl urea derivative, as represented by formula I, with an RORγt inhibiting activity, and a preparation process thereof, and a pharmaceutical composition comprising the compound. Further disclosed is use of the compound for treating an RORγt-related disease. 2. The method according to claim 1 , wherein m is 1 and Ris selected from a group consisting of —H claim 1 , —Cl claim 1 , —F claim 1 , and —CH.3. The method according to claim 2 , wherein r is 1 and Ris selected from a group consisting of —H claim 2 , —Cl claim 2 , —F claim 2 , —CF claim 2 , —OCF claim 2 , —CN claim 2 , C-Calkyl and heteroaryl.4. The method according to claim 2 , wherein r is 2 and Ris selected from a group consisting of —Cl claim 2 , —F claim 2 , —CF claim 2 , —OCF claim 2 , —CN claim 2 , and C-Calkyl.5. The method according to claim 1 , wherein Ris optionally selected from a group consisting of hydrogen claim 1 , halogen claim 1 , cyano claim 1 , hydroxyl claim 1 , and C-Calkyl.8. The method according to claim 1 , wherein the subject has RORγt receptor related diseases.9. The method according to claim 8 , wherein the diseases are multiple sclerosis claim 8 , rheumatoid arthritis claim 8 , collagen-induced arthritis claim 8 , psoriasis claim 8 , inflammatory bowel disease claim 8 , encephalomyelitis claim 8 , clonal disease claim 8 , asthma claim 8 , or cancer.10. The method according to claim 9 , wherein the cancer is prostate cancer. This application is a continuation application of U.S. patent application Ser. No. 16/312,436, filed Dec. 21, 2018, which is a national phase application of international patent application No. PCT/CN2017/088956, filed on Jun. 19, 2017, which claims the priority of Chinese Patent Applications No. 201610455177.X, field on Jun. 22, 2016, and the priority of Chinese Patent Applications No. 201610455207.7, field on Jun. 22, 2016. The entire contents of those applications ...

BIARYL UREA DERIVATIVE OR SALT THEREOF AND PREPARATION PROCESS AND USE FOR THE SAME

The present invention discloses a biaryl urea RORγt inhibitor, and specifically relates to a biaryl urea derivative, as represented by formula I, with an RORγt inhibiting activity, and a preparation process thereof, and a pharmaceutical composition comprising the compound. Further disclosed is use of the compound for treating an RORγt-related disease. 13-. (canceled)5. The compound or the pharmaceutically acceptable salt thereof according to claim 4 , wherein B is a phenyl or a six-membered heteroaryl.6. The compound or the pharmaceutically acceptable salt thereof according to claim 5 , wherein Rand Rare each independently selected from a group consisting of hydrogen and methyl.7. The compound or the pharmaceutically acceptable salt thereof according to claim 6 , wherein R1′ is selected from a group consisting of hydrogen claim 6 , —OCF claim 6 , —OCHF claim 6 , —CFand heteroaryl.8. The compound or the pharmaceutically acceptable salt thereof according to claim 7 , wherein m is 1 and Ris selected from a group consisting of —H claim 7 , —Cl claim 7 , —F claim 7 , and —CH.9. The compound or the pharmaceutically acceptable salt thereof according to claim 8 , wherein r is 1 and Ris selected from a group consisting of —H claim 8 , —Cl claim 8 , —F claim 8 , —CF claim 8 , —OCF claim 8 , —CN claim 8 , C-Calkyl and heteroaryl.10. The compound or the pharmaceutically acceptable salt thereof according to claim 8 , wherein r is 2 and Ris selected from a group consisting of —Cl claim 8 , —F claim 8 , —CF claim 8 , —OCF claim 8 , —CN claim 8 , and C-Calkyl.11. The compound or the pharmaceutically acceptable salt thereof according to claim 4 , wherein Z is O or NH.12. The compound or the pharmaceutically acceptable salt thereof according to claim 11 , wherein Ris optionally selected from a group consisting of hydrogen claim 11 , halogen claim 11 , cyano claim 11 , hydroxyl claim 11 , and C-Calkyl.13. The compound or the pharmaceutically acceptable salt thereof according to claim ...

Analytics and reporting tool for human capital management (hcm)

Described herein is a reporting framework. In accordance with one aspect of the framework, data is modeled into business-oriented data, wherein the data utilizes flat-table data modules. A subset is selected from the business-oriented data, and a dataset may be retrieved based on the subset. The retrieved dataset may be converted into structured query language (SQL) expression, which is then used to report the dataset.

MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR-GAMMA) FOR USE IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES

The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ. 2. The compound or salt according to claim 1 , wherein Ris heteroaryl substituted with C-Calkyl.3. The compound or salt according to or claim 1 , wherein Ris pyridinyl substituted with methyl.4. (canceled)5. The compound or salt according to claim 1 , wherein Ris methyl.6. The compound or salt according to claim 1 , wherein k is 1 and Ris Cl or F.78-. (canceled)9. The compound or salt according to claim 1 , wherein Ris H.10. The compound or salt according to claim 1 , wherein Ris methyl.11. The compound or salt according to claim 1 , wherein p is 0.12. The compound or salt according to claim 1 , wherein Ris C-Ccycloalkyl optionally substituted with one or two F or methyl.13. The compound or salt according to claim 12 , wherein Ris cyclobutyl substituted with methyl or two F.14. The compound or salt according to claim 12 , wherein Ris cyclopentyl.15. The compound or salt according to claim 1 , wherein Ris methyl substituted with cyclopropyl.16. The compound or salt according to wherein the compound is selected from:(S)—N-(3-((4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl)methyl)-5-fluoro-2-methylphenyl)-2-methylpyrimidine-5-carboxamide;(S)—N-(5-chloro-3-((4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl)methyl)-2-methylphenyl)-6-methylnicotinamide);(S)-3-cyano-N-(3-((4-(3,3-difluorocyclobutanecarbonyl)-3-methylpiperazin-1-yl)methyl)-5-fluoro-2-methylphenyl)benzamide;(S)—N-(5-chloro-3-((4-(2-cyclopropylacetyl)-3-methylpiperazin-1-yl)methyl)-2-methylphenyl)-6-methylnicotinamide;N-(5-fluoro-2-methyl-3-(((S)-3-methyl-4-((cis)-3-methylcyclobutanecarbonyl)piperazin-1-yl)methyl)phenyl)-6-methylnicotinamide;N-(5-fluoro-2-methyl-3-(((S)-3-methyl-4-((trans)-3-methylcyclobutanecarbonyl)piperazin-1-yl)methyl)phenyl)-6-methylnicotinamide;N-(5-chloro-2-methyl-3-(((S)-3-methyl-4-((trans)-3-methylcyclobutanecarbonyl)piperazin-1 ...

ROBOT COOPERATION METHOD AND DEVICE, ROBOT, ROBOT SYSTEM, AND COMPUTER PROGRAM PRODUCT

A robot cooperation method includes: acquiring a team task, determining each robot in a robot team; determining a leader robot for the robot team; and determining whether any one robot in the robot team is the leader robot. If so, the any one robot generates and sends control instructions that respectively enable one or more robots in the robot team to cooperatively complete the team task; otherwise, it receives and executes a control instruction from the leader robot. Determination of the leader robot can include evaluating a leadership competence of each cooperating robot in the team, and assigning the robot with the highest leadership competence as the leader robot. A device in a robot to enable it to cooperatively work with other robots in a robot team, a robot having the device, and a robot system having more than one robot can employ the method. 1. A method for cooperating a plurality of robots in a robot network , comprising:acquiring information of a team task;determining, based on the acquired information of the team task, each robot in a robot team in the robot network, the robot team comprising at least one cooperating robot;determining a leader robot of the robot team; anddetermining whether any one robot in the robot team is the leader robot, and generating at least one control instruction configured respectively to enable one or more robots in the robot team to work cooperatively to complete the team task; and', 'sending the at least one control instruction respectively to the one or more robots in the robot team;', 'or if otherwise, in the any one robot:', 'determining the leader robot in the robot team;', 'receiving a control instruction from the leader robot; and', 'executing the control instruction., 'if so, in the any one robot2. The method of claim 1 , wherein the determining a leader robot of the robot team is based on leadership competence evaluation claim 1 , and comprises:determining a leadership competence of each of the at least one ...

METHOD AND DEVICE FOR OBTAINING DEMAND-TRANSPORT CAPACITY UNMATCHED REGION IN CAR-CALLING SERVICES, AN APPARATUS AND NON-VOLATILE COMPUTER STORAGE MEDIUM

A method and device for obtaining a demand-transport capacity unmatched region in car calling services, an apparatus and non-volatile computer storage medium. The method comprises: obtaining data of departure coordinates and destination coordinates of the car-call respectively from a plurality of historical order data; clustering the data of the departure coordinates and destination coordinates respectively to obtain a departure coordinate cluster set and a destination coordinate cluster set; building M×N demand regions respectively from M departure coordinate clusters in the departure coordinate cluster set and N destination coordinate clusters in the destination coordinate cluster set; obtaining a demand region in which a ratio of the number of accepted orders of the user to a total number of orders is less than a preset order-accepting ratio threshold from the M×N demand regions as the demand-transport capacity unmatched region. 1. A method for obtaining a demand-transport capacity unmatched region in car calling services , wherein the method comprises:obtaining data of departure coordinates and destination coordinates of the car-call respectively from a plurality of historical order data;clustering the data of the departure coordinates and destination coordinates respectively to obtain a departure coordinate cluster set and a destination coordinate cluster set;building M×N demand regions respectively from M departure coordinate clusters in the departure coordinate cluster set and N destination coordinate clusters in the destination coordinate cluster set;obtaining a demand region in which a ratio of the number of accepted orders of the user to a total number of orders is less than a preset order-accepting ratio threshold from the M×N demand regions as the demand-transport capacity unmatched region.2. The method according to claim 1 , wherein the clustering the data of the departure coordinates and destination coordinates respectively to obtain a departure ...

METHOD AND ELECTRONIC DEVICE FOR STARTING APPLICATION

A method and an electronic device for starting an application are disclosed. The method includes: receiving, by a first virtual machine, startup information and creating a startup identifier associated with the startup information; receiving, via the first virtual machine, a startup instruction for starting an application on a second virtual machine; acquiring startup information corresponding to the startup instruction, the startup information including information of the second virtual machine and information of the application on the second virtual machine; starting the second virtual machine according to the information of the second virtual machine; and starting the application on the second virtual machine according to the information of the application on the second virtual machine. 1. A method for starting an application , comprising:receiving, by a first virtual machine, startup information and creating a startup identifier associated with the startup information;receiving, via the first virtual machine, a startup instruction for starting an application on a second virtual machine;acquiring startup information corresponding to the startup instruction, the startup information comprising information of the second virtual machine and information of the application on the second virtual machine;starting the second virtual machine according to the information of the second virtual machine; andstarting the application on the second virtual machine according to the information of the application on the second virtual machine;wherein the receiving, via the first virtual machine, a startup instruction for starting an application on a second virtual machine comprises:receiving, via the first virtual machine, a startup instruction for starting the application on the second virtual machine that is generated after the startup identifier is triggered;wherein the receiving, by a first virtual machine, startup information comprises:determining, by a virtualization layer ...

DEVICE DETECTION METHOD AND SYSTEM, ELECTRONIC DEVICE, CLOUD ROBOT SYSTEM, AND COMPUTER PROGRAM PRODUCT

The present application provides a device detection method and system, an electronic device, a cloud robot system. The method includes: in a first operating system, when a device detection instruction sent by a device detection program is detected, determining a driving program operation instruction corresponding to the device detection instruction, and transmitting the driving program operation instruction to a second operating system; in the second operating system, operating a corresponding driving program according to the driving program operation instruction, and feeding back an operation result to the first operating system; and in the first operating system, returning the operation result to the device detection program. 1. A device detection method , comprising:in a first operating system, when a device detection instruction sent by a device detection program is detected, determining a driving program operation instruction corresponding to the device detection instruction, and transmitting the driving program operation instruction to a second operating system;in the second operating system, operating a corresponding driving program according to the driving program operation instruction, and feeding back an operation result to the first operating system; andin the first operating system, returning the operation result to the device detection program.2. The method according to claim 1 , wherein said operating a corresponding driving program according to the driving program operation instruction refers to:only when it is determined that the driving program operation instruction satisfies preset security conditions, operating the corresponding driving program according to the driving program operation instruction.3. The method according to claim 2 , wherein claim 2 , the preset security conditions comprise:the security level of the first operating system is greater than a preset level; or,the first operating system is an operating system securely running in a ...

VIRTUAL MACHINE CREATION METHOD AND APPARATUS

A virtual machine creation method and apparatus are disclosed. The method includes: acquiring a first installation package of a first application; determining essential environmental data corresponding to the first installation package; obtaining a simplified operating system via compilation according to the essential environmental data; packaging the simplified operating system and the first installation package to obtain a virtual machine installation package; and running the virtual machine installation package to create a virtual machine. 1. A virtual machine creation method , comprising:acquiring a first installation package of a first application;determining essential environmental data corresponding to the first installation package;obtaining a simplified operating system via compilation according to the essential environmental data;packaging the simplified operating system and the first installation package to obtain a virtual machine installation package; andrunning the virtual machine installation package to create a virtual machine.2. The method according to claim 1 , wherein prior to the determining essential environmental data corresponding to the first installation package claim 1 , the method further comprises:determining a security level of the first application; anddetermining, according to the security level of the first application, that a virtual machine needs to be created for the first application.3. The method according to claim 2 , wherein after the running the virtual machine installation package to create a virtual machine claim 2 , the method further comprises:acquiring a second installation package;determining that the second installation package and the first installation package of the first application satisfy a predetermined condition; andinstalling the second installation package to the virtual machine.4. The method according to claim 3 , wherein the predetermined condition comprises:the second installation package is an updated ...

Dynamic Layout Management for Robotics Warehouse System

Embodiments implement a minispace concept to dynamically manage layout of a robotics warehouse system. The warehouse space is divided into a plurality of equally sized minispaces, each corresponding to a standard rack footprint. Each minispace is identified by tagging with a unit location ID and attribute(s) such as coordinates. Minispaces may be referenced in a task planning process flow that initially comprises determining stock and rack, followed by determining a relevant workstation. The task is then assigned to an appropriate robot, and a travel route is planned (e.g., shortest path in minispace layout). Robot actions within the route are then planned and executed by the warehouse management system according to the minispace layout. Minispaces allow a robot to identify each minispace by the tagging, and to plan the next movement accordingly. The use of minispaces may facilitate collision avoidance by grouping actions together and allowing performance of minispace locking/checking procedures. 1. A computer-implemented method comprising an in-memory database engine:dividing a warehouse space into a plurality of minispaces having a same dimension;storing the plurality of minispaces in an in-memory database;storing a warehouse layout model in the in-memory database;storing a location map model in the in-memory database;referencing, in response to a task specifying a product, the plurality of minispaces to determine a rack of the warehouse space relevant to the product;referencing the plurality of minispaces to determine a static workstation of the warehouse space to receive the rack;referencing the plurality of minispaces and the warehouse layout model to prepare a route plan between the rack and the static workstation, preparation of the route plan not considering the location model;referencing the location map model, the layout model, and the route plan to prepare a robot action plan to move the rack to the static workstation; andcommunicating with a robotics ...

Model Driven Layout Design for Robotics Warehouse

Embodiments relate to the design of a (good-to-person) robotics warehouse, and in particular to a warehouse layout model. The warehouse layout model is interposed between a warehouse map/location model containing concrete physical location data (e.g., QR codes), and an overlying warehouse management system generally configured to interact with a robotics system. The warehouse layout model defines basic elements such as •rackspace, •rackspace block, •lane, and •workstation. Those elements may in turn be arranged into basic patterns such as •storage area, •workstation area, •entry area, and others. The layout model also includes a set of basic traveling rules governing the movement of robots in relation to the elements and patterns. The layout model serves as a translator between the generalized warehouse management system, and the location/map model specific to a particular warehouse footprint. The warehouse layout model facilitates adapting the robotic system to changes as the warehouse expands and evolves. 1. A computer-implemented method comprising:receiving instructions to create a warehouse layout model from a warehouse location model comprising physical locations recognized by a robotics system; a plurality of elements,', 'a plurality of patterns assembled from one or more of the plurality of elements, and', 'robot movement rules dictated by one or more of the plurality of patterns, wherein the creating comprises the warehouse layout model mapping one or more of the plurality of elements, the plurality of patterns, and the robot movement rules to the physical locations; and, 'creating the warehouse layout model according to the instructions by applying the warehouse location model to a warehouse layout model template comprising,'}communicating the warehouse layout model for display to the user.2. A method as in wherein the creating comprises mapping claim 1 , by the warehouse layout model claim 1 , one of the plurality of elements comprising a product rackspace ...

Method and apparatus for displaying application image

A method and a device for displaying an application image are provided, and the method includes the following steps: receiving a display request from a second operating system, and reading the application image stored in a storage area; judging whether it is required to process the application image through a window manager according to the configuration of the local image display system, and if required, sending the application image to the window manager, and sending the application image processed by the window manager to a display graphics library for processing; if not, directly sending the application image to the display graphics library for processing; and acquiring the location of the display memory through a display driver, sending the application image processed by the display graphics library to the display memory, and displaying the application image through the display memory. Using the solution, the application image of the installable operating system can be displayed in the local operating system.

Novel m3 muscarinic acetylcholine receptor antagonists

Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.

Prolyl hydroxylase inhibitors

The invention described herein relates to certain 2,4-dioxo-l,2,3,4-tetrahydro-7- quinazolinecarboxamide derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.

Retinoid-related orphan gamma receptor modulators (ROR-gamma) for use in the treatment of autoimmune and inflammatory diseases

Un compuesto de la fórmula I o una de sus sales farmacéuticamente aceptables**Fórmula** en donde: R1 es: - alquilo C1-C6; - metilo sustituido con i) cicloalquilo C3-C5; ii) fenoxi; o iii) un fenilo y un segundo sustituyente seleccionado del grupo que consiste en: metilo, halo y metoxi; - etilo sustituido con i) fenilo, dicho fenilo está opcionalmente sustituido con halo o metoxi o ii) heteroarilo; - bencilo, en donde el grupo fenilo de dicho bencilo está opcionalmente sustituido con halo, metoxi o SO2CH2CH3; - alquenilo C2 opcionalmente sustituido con un F y un fenilo; - cicloalquilo C3-C7, dicho cicloalquilo está opcionalmente sustituido con uno o dos sustituyentes seleccionados del grupo que consiste en fenilo, metilo y F; o dicho cicloalquilo está opcionalmente fusionado con un anillo fenilo; - heterocicloalquilo opcionalmente sustituido con uno o dos alquilos C1-C3; - heteroarilo opcionalmente sustituido con uno a dos sustituyentes seleccionados del grupo que consiste en: alquilo C1-C3, alcoxi C1-C3 y CF3; y - fenilo sustituido con uno a tres sustituyentes seleccionados del grupo que consiste en: i) halo; ii) CN; iii) alquilo C1-C3 opcionalmente sustituido con uno a tres F; iv) alcoxi C1-C3; v) (CH2)nNRaRb; vi) C(O)CH3; y vii) CH2OCH3; R2 es halo o alquilo C1-C3; R3 es halo o metilo; R4 es H o metilo; R5 es alquilo C1-C3; R6 es alquilo C1-C3; R7 está seleccionado del grupo que consiste en: - alquilo C1-C7 opcionalmente sustituido con uno o más sustituyentes seleccionados del grupo que consiste en halo, cicloalquilo C3-C5 y CF3; - cicloalquilo C3-C7 opcionalmente sustituido con uno o dos sustituyentes seleccionados del grupo que consiste en F, CH2F, CHF2, metilo y metoxi, cada k es 0 ó 1; cada p es 0 ó 1; cada n es 0, 1 ó 2; cada Ra es H o alquilo C1-C3; cada Rb es H o alquilo C1-C3; A compound of the formula I or a pharmaceutically acceptable salt thereof ** Formula ** wherein: R 1 is: - C 1 -C 6 alkyl; - methyl substituted with i) C3-C5 cycloalkyl; ii) phenoxy; ...

Prolyl Hydroxylase Inhibitors

The invention described herein relates to certain 4-oxo-2-thioxo-1,2,3,4-tetrahydro-7-quinazolinecarboxamide derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.

Prolyl hydroxylase inhibitors

The invention described herein relates to certain 4-oxo-2-thioxo- 1,2,3, 4-tetrahydro-7-quinazolinecarboxamide derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.

Device detection method and system, electronic device, cloud robot system, and computer program product

The present application provides a device detection method and system, an electronic device, a cloud robot system. The method includes: in a first operating system, when a device detection instruction sent by a device detection program is detected, determining a driving program operation instruction corresponding to the device detection instruction, and transmitting the driving program operation instruction to a second operating system; in the second operating system, operating a corresponding driving program according to the driving program operation instruction, and feeding back an operation result to the first operating system; and in the first operating system, returning the operation result to the device detection program.

Method and apparatus for starting application program

The present invention provides a method and apparatus for starting an application. The method includes: receiving, via a first virtual machine, a startup instruction for starting an application on a second virtual machine, and acquiring startup information corresponding to the startup instruction, the startup information including information of the second virtual machine and information of the application on the second virtual machine; and starting the second virtual machine according to the information of the second virtual machine, and starting the application on the second virtual machine according to the information of the application on the second virtual machine. According to the technical solutions of the present application, a user is capable of directly starting the application on the second virtual machine in the operating environment of the first virtual machine, with no need to switch an operating system to find an application, and thus user's operations are convenient.

Biaryl urea derivative or salt thereof and preparation process and use for the same

The present disclosure discloses a biaryl urea RORγt inhibitor, and specifically relates to a biaryl urea derivative, as represented by formula I, with an RORγt inhibiting activity, and a preparation process thereof, and a pharmaceutical composition comprising the compound. Further disclosed is use of the compound for treating an RORγt-related disease.

Modulators of the retinoid-related orphan receptor gamma (ror-gamma) for use in the treatment of autoimmune and inflammatory diseases

Prolyl hydroxylase inhibitors

Novel m3 muscarinic acetylcholine receptor antagonists

Novel m3 muscarinic acetylcholine receptor antagonists

Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.

NEW ANTAGONISTS OF THE M3 ACETILCOLINE MUSCARINIC RECEPTOR

Se proporcionan antagonistas del receptor muscarínico de acetilcolina y métodos de uso de los mismos. Muscarinic acetylcholine receptor antagonists and methods of use thereof are provided.

Compounds derived from n- (3 - {[4- (alkyl / cycloalkyl-carbonyl) piperazin-1-yl] methyl} phenyl) formamide, orphaned gamma receptor retinoid-related modulators (ror-gamma); pharmaceutical composition; and its use in the treatment of multiple sclerosis and / or psoriasis.

MODIFICATIONS OF RETINOID CONTAINER ORFANIC RECEPTOR C (ROR-C) FOR USE IN THE PROTECTION AGAINST AUTOMOBILE AND INFLAMMATORY DISEASES

Η παρούσα εφεύρεση σχετίζεται με καινοφανείς τροποποιητές του σχετικού με ρετινοειδή ορφανού υποδοχέα γ (RORγ) και με τη χρήση αυτών στην αγωγή έναντι νόσων που διαμεσολαβούνται από τον RORγ. The present invention relates to novel modifiers of the retinoid-related orphan gamma receptor (RORγ) and their use in the treatment of RORγ-mediated diseases.

Preparation and use of therapeutic hydrogels

Systems and methods of preparing therapeutic materials from amniotic tissue are discussed. In some embodiments the amniotic tissues are ground and used to generate hydrogels. Variations in the materials and preparation methods result in attributes, such as preservation of protein activity and/or thickening time, that are applicable to various therapeutic uses. As an illustrative example, a hydrogel of finely ground amniotic tissue can be freeze-dried and cryoground to particle sizes suitable for use in ophthalmic, oral, or other treatments. In some embodiments, the invention includes to a highly efficient and effective cryogenic grinding process and mechanic engineering design to make fine, uniform sizes and highly dissoluble powder particles for industry large scale manufacturing. This is accomplished while maintaining the original important physical, chemical and biological characteristics of the Materials being grinded. Exemplary embodiments include grinding of amniotic tissue, proteins, collagen, mucopolysaccharide and freeze-dried tissues, for the generation of therapeutic materials.

Building site dust suppression device for construction

本实用新型公开了一种建筑施工用工地抑尘装置，包括清洗机箱，所述清洗机箱的一端通过螺栓连接有水平设置的固定块，所述清洗机箱的顶部通过螺栓连接有水平设置的支撑金属板，所述支撑金属板的顶部两侧均通过螺栓连接有竖直设置的支撑侧板，两个所述支撑侧板相靠近的一侧均通过螺栓连接有竖直设置的安装板，且安装板的一侧通过螺栓连接有喷头。本实用新型中，抑尘装置的固定块以及清洗机箱的底部均设置在挖好的坑中，使得支撑金属板与地面保持水平，在工地工程车经过时，工程车位于支撑金属板的顶部，两侧的支撑侧板上设置的喷头可以对车身两侧进行喷水，将车身打湿，快捷的进行抑尘，且方便人员的操作。

Method and Apparatus for Intelligent Management of a Network Element

A network element (NE) includes an intelligent interface (II) with its own operating environment rendering it active during the NE boot process, and with separate intelligence allowing it to take actions on the NE prior to, during, and after the boot process. The combination of independent operation and increased intelligence provides enhanced management opportunities to enable the NE to be controlled throughout the boot process and after completion of the boot process. For example, files may be uploaded to the NE before or during the boot process to restart the NE from a new software image. The II allows this downloading process to occur in parallel on multiple NEs from a centralized storage resource. Diagnostic checks may be run on the NE, and files, and MIB information, and other data may be transmitted from the II to enable a network manager to more effectively manage the NE.

Novel m3 muscarinic acetylcholine receptor antagonists

Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.

Ccr8 antagonists

The invention relates to certain substituted bicyclicaryl-benzenesulfonamide and their use for inhibiting the chemokine receptor nominated CCR8. The generic structure for these compounds, as defined herein is that of a benzenesulfonamide of Formula (I).

Prolyl hydroxylase inhibitors

The invention described herein relates to certain 4-oxo-2-thioxo- 1,2,3,4- tetrahydrothienopyrimidine-6-carboxamide derivatives of formula (I) and (II); which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.

Communication method and apparatus, electronic device, and program product

8-oxo-3-azabicyclo[3.2.1]octane compound or salt thereof, and preparation method therefor and use thereof

Provided are a group of 8-oxa-3-azabicyclo[3.2.1]octane compounds of formula (I) used as ATR inhibitors, and a preparation method therefor, a pharmaceutical composition containing same, and the use thereof in the treatment or prevention of ATR-related diseases.

8-oxa-3-azabicyclo[3.2.1]octane compounds or salt thereof, and preparation method and use thereof

Provided are a group of 8-oxa-3-azabicyclo[3.2.1]octane compounds of formula (I) used as ATR inhibitors, and a preparation method therefor, a pharmaceutical composition containing same, and the use thereof in the treatment or prevention of ATR-related diseases.

Durable search queries for reliable distributed data retrieval

A data intake and query system executes a search query at a first execution time for querying events having associated time stamps within a first time period characterized by a first start time and a first end time. The first start time is computed based upon a time indicated by reference time information stored prior to execution of the search query. The system determines whether execution of the search query completed successfully based upon a first search result obtained from executing the search query. If the first execution of the search query was not successful, the system computes for a second execution of the search query after the first execution, a second time period using the reference time information. The second execution is configured to query events with associated timestamps that fall within a second time period that includes the first time period and an additional time period.

Method for evaluating permeability of hydrate-bearing sediment

J **, ltffi2>Mi@$i ()W) (43) Pd', WO 2023/025326 A9 2023 4 3 P 2 (02.03.2023) W IPO I PCT (51) M §':-4 T,1 }% : (CN)o.~ Ti9 (WANG, Shuo); i GO1N 15/08 (2006.01) NA E -K f Y 66 , Shandong 266580 (CN)o (21) MI,5i%%: PCT/CN2022/116966 3fXbJk(ZHIANG,Huanhuan); TiT X A E - l M §66 , Shandong 266580 (CN)o (22) M $,i EH : 20224 9 ] 5 H (05.09.2022) -E R(WANG, Bin); + lW T WtiA i X AX (25) $ jfji : + I N Vl Y §66, Shandong 266580 (CN)o A J9j ((WEI, Zhoutuo); N A Wii X A X (26)(-K - M 66, Shandong 266580 (CN)o . #) (30) R t $fi : K (GE, Xinmin); + lT i X A K 202210883800.7 202247A26H (26.07.2022) CN 41f Y §§66 , Shandong 266580 (CN) o I'J 202210883799.8 202247A26H (26.07.2022) CN (DENG, Shaogui); F lid N i X X -K (71) iA : ;F A - t A (± $ (CHI- 4flY¶66t, Shandong 266580 (CN)o NA UNIVERSITY OF PETROLEUM (EAST CHINA)) (74) 4IJtkA :--N- 4*4 I iP*AtY I R'i [CN/CN]; + l U T N h A i X A X -K l N (QINGDAO LAWSCI INTELLECTUAL PROPERTY _669, Shandong 266580 (CN)o CO.,LTD.); +$$W 11I% Lid4ki52 (72) &fl A: JIW (XING, Lanchang); F+ Pd Lb 3*$d 1LtURFl)2401, Shandong 266100 (CN)o A A rZii A -K fl Y6 66 9, Shandong 266580 (54) Title: METHOD FOR EVALUATING PERMEABILITY OF HYDRATE-BEARING SEDIMENT -~(54)&lZA:7 1f% 4 cc FF AA AA Complex conductivity spectrum DD of a hydrate-bearing sediment e--- -- BB Calculate 4 CC Complex conductivity real part FF DD Complex conductivity imaginary part EE Equivalent dielectric constant E FF Theoretical model 3 GG Hydrate saturation (57) Abstract: A method for evaluating the permeability of a hydrate-bearing sediment, comprising: obtaining a complex conductivity spectroscopy of a hydrate-bearing sediment; calculating a hydrate saturation on the basis of the complex conductivity spectroscopy; calculating a formation factor by using an Archie's first law or calculating a formation factor by using a complex conductivity real part, a complex conductivity imaginary part and conductivity of pore water; and calculating the ...

8-oxo-3-azabicyclo[3.2.1]octane compound or salt thereof, and preparation method therefor and use thereof

Communication method and apparatus, electronic device, and program product

Smart cat litter box

Novel m3 muscarinic acetylcholine receptor antagonists

Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.

System and method for input tool invocation and proxy device

A system and a method for input tool invocation and a proxy device enable an installable operating system to perform input operation by invoking the input tool of a local operating system, such as a soft keyboard of the local operating system, an input method of the local operating system, or a soft keyboard and an input method of the local operating system. Even an operating system not installed with input tools can perform input operation by invoking an input tool of a local operating system, thereby avoiding repeated installations of input tools for different operating systems, and resolving the issue of large resource usage caused by repetitive installations of input tools.

Self-service vending device control method

A method for controlling a self-service vending device to be safely opened, a server and a self-service vending system are provided. The method comprises: acquiring first position information of a mobile terminal when it is detected that the mobile terminal requests the self-service vending device to be opened by scanning two-dimensional code information on the self-service vending device, and acquiring identifier information of the self-service vending device according to the two-dimensional code information (101); querying a preset database according to the identifier information of the self-service vending device, and acquiring second position information corresponding to the self-service vending device (102); and calculating a distance between the mobile terminal and the self-service vending device according to the first position information and the second position information, and determining whether the distance is within a preset safe distance range (103); and when the distance is within the preset safe distance range, controlling the self-service vending device to be opened (103a). Through the method, it can be determined whether a code scanning-based cabinet opening action of a user is a real action of the user, so as to improve the safety of the user's property.

Preparation and use of therapeutic hydrogels

8-oxo-3-azabicyclo[3.2.1]octane compound or salt thereof, and preparation method therefor and use thereof

Provided are a group of 8-oxa-3-azabicyclo[3.2.1]octane compounds of formula (I) used as ATR inhibitors, and a preparation method thereof, a pharmaceutical compositions containing same, and the use thereof in the treatment or prevention of ATR-related diseases.

一种橡胶产品加工用便于加料的反应釜

本实用新型公开了一种橡胶产品加工用便于加料的反应釜，包括反应釜本体，所述反应釜本体一侧外壁安装有电动导轨，且电动导轨一侧外壁滑动连接有电动滑块，所述电动滑块一侧外壁安装有安装架，且安装架底部一侧内壁两端均安装有连接杆，两个连接杆的顶部外壁转动连接有同一个第一储物壳体，所述安装架一侧内壁两端均转动连接有电动伸缩杆，且电动伸缩杆另一端与第一储物壳体一侧外壁转动连接，所述反应釜本体底部外壁四角均安装有支撑腿。本实用新型中，设置有电动机、上料壳体、旋转轴、第一螺旋叶片和第二储物壳体，能够快速将基本材料生胶加入到反应釜壳体中，减少了工作人员的工作量，提高了工作效率。

一种全自动防尘调焦系统

本实用新型公开了一种全自动防尘调焦系统。本实用新型包括相机和密封箱，相机密封于密封箱内，相机的头部安装有镜头，镜头远离相机的一端安装有用于调焦的镜头调焦齿轮圈，镜头和镜头调焦齿轮圈均位于密封箱内；密封箱内还安装有驱动电机，驱动电机的电机轴上安装有电机齿轮，电机齿轮与镜头调焦齿轮圈相啮合；镜头调焦齿轮圈所对应的密封箱一端设置有阶梯孔，阶梯孔内卡接有高透镜，高透镜与阶梯孔之间设置有透镜密封圈。本实用新型整个结构完全密封做到防尘防水，可以使电子设备达到一个更高的IP等级；可以使控制器自动调节镜头的焦距，不仅调焦的精度提高，而且更易于操作，减少了手动调焦的麻烦，在实际应用中可适用于更多的场景。

Metal powder preparation system and preparation method

The present application relates to a metal powder preparation system and method in the technical field of metal powder preparation for additive manufacturing. The metal powder preparation system includes a medium frequency smelting furnace, a homogeneous insulated quantitative pouring furnace, a precision-controlled liquid level temperature pouring ladle, and a plurality of groups of atomization mechanisms connected in sequence. The present application improves the preparation quality of the metal powder, so that the parameters such as the powder particle size, sphericity, fluidity, oxygen content, component distribution, and particle size distribution of the metal powder can all meet the requirements of high-quality metal additive manufacturing, achieving efficient and continuous preparation of the metal powder at the same time.

Self-service vending device control method

Automatic trash bag sealing device in an automatic cat litter box and automatic cat litter box

The present disclosure discloses an automatic trash bag sealing device for an automatic cat litter box and an automatic cat litter box. In the automatic trash bag sealing device, a drive motor drives a first rod and/or a second rod to rotate, thereby driving a pushing member to move towards a sealing member, and the trash bag is sealed when the sealing member is interfaced with the pushing member. The sealing device has fewer parts and is simple to assemble, effectively reducing the difficulty of process assembly and the overall cost of the automatic cat litter box.

一种玉米种植用肥料混合装置

本实用新型公开了一种玉米种植用肥料混合装置，包括本体，所述本体的顶部固定连接有混合箱，所述混合箱顶部的左侧开设有进料口，所述混合箱左侧的上端设置有混合机构，所述混合箱左侧的下端固定连接有固定板，所述固定板的顶部固定安装有第一电机，所述第一电机的输出轴固定连接有转动杆。本实用新型通过第二电机的输出轴固定连接有旋转杆，旋转杆的外表面固定连接有绞龙，起到了初步混合的效果，通过第一电机的输出轴固定连接有转动杆，转动杆的上下两端均固定连接有搅拌叶，起到了再次混合的效果，通过混合箱顶部的左侧开设有进料口，起到了加入不同肥料的效果，解决了现有的施肥都为单独一种的肥料进行施肥的问题。

Bacillus subtilis dk-03 and use thereof

The present disclosure provides a Bacillus subtilis DK-03 and use thereof. The B. subtilis DK-03 has been deposited at China Center for Type Culture Collection (CCTCC) on January 20, 2021 under accession number M2021018. The B. subtilis DK-03 provided by the present disclosure has excellent enzyme-producing and antibacterial properties and high safety, which can be used as a microbial inoculant or a feed additive to improve the balance of intestinal flora in donkey foals, improve an immune function of a donkey foal, promote the digestion and absorption of nutrients in a donkey foal feed, increase the growth performance of the donkey foal, and help improve economic benefits of donkey farms.

Eyesight protection device, eyesight protection system and detection method for eyesight protection device

The present disclosure provides an eyesight protection device, an eyesight protection system and an detection method for the eyesight protection device, which belongs to the technical field of communication, and can solve some problems in the prior art. The present disclosure provides an eyesight protection device, which includes: a millimeter-wave radar detection circuit, a control circuit and an alarm circuit. The millimeter-wave radar detection circuit is configured to detect a distance between a user and a reading material read by the user. The control circuit is configured to generate a first control signal at least when it is determined that the distance detected by the millimeter-wave radar detection circuit is smaller than a first predetermined value. The alarm circuit is configured to send out an alarm signal in response to the first control signal.

Novel m3 muscarinic acetylcholine receptor antagonists

Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.

8-oxa-3-azabicyclo[3.2.1]octane compounds or salt thereof, and preparation method and use thereof

Provided are a group of 8-oxa-3-azabicyclo[3.2.1]octane compounds of formula (I) used as ATR inhibitors, and a preparation method thereof, a pharmaceutical compositions containing same, and the use thereof in the treatment or prevention of ATR-related diseases.

Human-computer interaction method and system of display device

Disclosed are a human-computer interaction method and system of a display device, which are used for providing a new interaction manner. A main control module is configured to receive an interactive instruction of a user and generate OSD data, and a data processing module is configured to superimpose and display a received video stream and the OSD data. The human-computer interaction system includes a data source generation module, a main control module and a data processing module. The data source generation module is configured to generate a video stream and send the video stream to the data processing module. The main control module is configured to receive an interactive instruction sent by a user, generate OSD data according to the interactive instruction, and transmit the OSD data to the data processing module. The data processing module is configured to superimpose the received video stream with the OSD data, and output the superimposed video stream to a display end for displaying to make a response to the interactive instruction sent by the user.

Flat panel detector and imaging system

A flat panel detector and an imaging system are disclosed. The flat panel detector includes: a main housing including a bottom wall and a side wall connected to the bottom wall, the bottom wall and the side wall defining an accommodating space; and a detection module in the accommodating space, the detection module including a support plate, a detection substrate, a driving circuit board, and a flexible circuit board, where the support plate includes a support surface and a bottom surface opposite to each other and a side surface connected therebetween, the detection substrate is fixed on the support surface, the driving circuit board is fixed on the support plate and is on a side of the support plate away from the detection substrate, and the flexible circuit board connects the detection substrate with the driving circuit board by passing the side surface of the support plate.

Method for improving saline-alkali land via fungus-vegetable rotation

The invention relates to crop planting, in particular to a method for improving saline-alkali land via fungus-vegetable rotation, provides a mode of crop rotation, including “cultivating edible fungi by using local straws--pacl<aging edible fungus residues for bag cultivation of ganoderma lucidum in spring--covering ganoderma lucidum with earth for cultivation of a second time-- cultivating short-season vegetables in autumn-- covering packages or sticks of waste pleurotus eryngii fungi with earth for fruiting a second time -- returning fungus residues to field for tomato cultivation”, and applies this mode to crop rotation of saline-alkali land in greenhouse facilities, so as to improve soil of saline-alkali lands. This method has high utilization rate of agricultural and forestry wastes, notable economic benefits, and can enhance soil utilization and reduce soil processing steps, and is favorable for carrying out soil improvement technology of saline-alkali lands, increasing income and realizing sustainable development of agriculture.