19-10-2017 дата публикации
Номер: US20170296662A1
Автор:
FENG Jingyi,
Jiang Zhihuan,
Jin Hongtao,
LI Ye,
Lin Ni,
Liu Hanqing,
Wang Aiping,
Wang Yingming,
Wei Jinfeng,
Yan Xiaodan,
Zhang Qianaian
Принадлежит:
The present invention relates to a use of alpha-(8-quinolinyloxy) mono-substituted phthalocyanine zinc for the treatment of psoriasis. The use is suitable for various type of psoriasis by utilizing photodynamic therapy. The photosensitizer is used to treat psoriasis by utilizing laser wave length of 670 nm, with high light sensitivity, fast photobleaching, short time needed in protection from light, and avoiding potential toxic and side-effect of photochemistry therapy by using ultraviolet irradiation. The preparation used in the use of α-(8-quinolinyloxy) mono-substituted phthalocyanine zinc for the treatment of psoriasis includes solution, cream, nanomicelle, microsphere etc, and mode of administration can be systemic or topical administration. The practicability of treating psoriasis by photodynamic therapy has been validated on cell and animal model. The use achieves perfect effect. 14-. (canceled)6. The method of claim 5 , further comprising treating psoriasis of the following types: psoriasis vulgaris claim 5 , pustular psoriasis claim 5 , erythrodermic psoriasis claim 5 , or arthritic psoriasis.7. The method of claim 5 , wherein the method of treating comprises a photodynamic therapy using a semiconductor laser with a wavelength of 670 nm as a light source.8. The method of claim 5 , further comprising providing the alpha-(8-quinolinyloxy) mono-substituted phthalocyanine zinc in a formulation comprising a solution claim 5 , a cream claim 5 , a nanomicelle claim 5 , a microsphere claim 5 , or a patch.9. The method of claim 6 , wherein the psoriasis is classified into blood heat type claim 6 , blood dryness type or blood stasis type.10. The method of claim 5 , wherein the psoriasis occurs in any body part of the human patient.11. The method of claim 5 , wherein the method of treatment comprises a photodynamic therapy using a semiconductor laser.12. The method of claim 5 , wherein the method of treatment comprises a photodynamic therapy using a light source.13. ...
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