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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 10. Отображено 10.
11-11-2009 дата публикации

Application of near infrared fluorescent chemical in lymphaden imaging and angiogram

Номер: CN0101574529A
Автор: SHI CHUNMENG, ZHANG CHAO, TAN XU, SU YONGPING, CHENG TIANMIN, CHUNMENG SHI, CHAO ZHANG, XU TAN, YONGPING SU, TIANMIN CHENG
Принадлежит:

The invention relates to an application of near infrared fluorescent chemical in lymphaden imaging and angiogram. The application of near infrared fluorescent chemical in lymphaden imaging and angiogram has the beneficial effects of simple operation, high marking efficiency, easy resolving and non toxic side effects, thus providing powerful technical support for clinician to effectively, accurately and safely resolving the lymphaden.

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Номер записи: 1
12-05-2010 дата публикации

Human alpha-defensin 5 antiviral active mutant polypeptide and preparation method and application

Номер: CN0101704886A
Автор: CHEN FANG, CHENG TIANMIN, SHEN MINGQIANG, SU YONGPING, WANG AIPING, WANG JUNPING, WANG SONG, FANG CHEN, TIANMIN CHENG, MINGQIANG SHEN, YONGPING SU, AIPING WANG, JUNPING WANG, SONG WANG
Принадлежит:

The invention relates to human alpha-defensin 5 (HD5) antiviral active mutant polypeptide and preparation method and application. The 21th glutamic acid in HD5 of the amino acid sequence of the mutant polypeptide can be replaced into arginine (E21R). The preparation method of the mutant polypeptide has two preparation methods, namely a solid-phase chemical synthesis method and a gene engineering preparation method. The HD5 mutant polypeptide of the invention has efficient antiviral activity under the conditions that serum exits or absents, and compared with parent HD5 polypeptide, the antiviral function of the invention is obviously improved. The HD5 mutant polypeptide of the invention is used for preventing viral infection, such as HSV, HPV, HIV and the like.

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Номер записи: 2
09-06-2010 дата публикации

Method for screening human alpha-defensin antivirus activity mutant

Номер: CN0101724633A
Автор: CHEN FANG, CHEN MO, CHENG TIANMIN, SU YONGPING, WANG AIPING, WANG JUNPING, XU YANG, FANG CHEN, MO CHEN, TIANMIN CHENG, YONGPING SU, AIPING WANG, JUNPING WANG, YANG XU
Принадлежит:

The invention discloses a method for screening a human alpha-defensin antivirus activity mutant, comprising the following steps of: targeted random mutation of human alpha-defensin, construction of a mutant library, targeted integration and homogeneity expression of the mutant in a CHO cell and screening of the effective antivirus activity mutant. The method obviously improves the human alpha-defensin molecule through mutation and screening on the basis of reserving the basic biology property, so as to open up a new path for searching and researching effective and low-toxicity antivirus medicines.

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Номер записи: 3
06-06-2012 дата публикации

Gene engineering preparation method of bioactive peptide containing human alpha defensin 5

Номер: CN0101525629B
Автор: CHEN MO, WANG JUNPING, WANG AIPING, SHEN MINGQIANG, SU YONGPING, CHENG TIANMIN, WANG SONG, MO CHEN, JUNPING WANG, AIPING WANG, MINGQIANG SHEN, YONGPING SU, TIANMIN CHENG, SONG WANG
Принадлежит:

The invention relates to a gene engineering preparation method of bioactive peptide containing human alpha defensin 5 and discloses a method for constructing expression vector of bioactive peptide gene containing human alpha-defensin 5 and for screening and fermenting in high density transformed yeast cloning strain thereof and the method for separating and purifying the bioactive peptide in fermentation supernatant. The invention also discloses the application of the bioactive peptide containing human alpha defensin 5 in preparing polypeptide medicine. The invention is applicable to realization of high efficiency fermentation expression through simple operation in the industrialized production scale and low-cost and high-efficiency purification and preparation of the bioactive peptide containing human alpha defensin 5 capable of highly effectively killing multiple pathogenetic bacteria and resisting virus such as HPV.

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Номер записи: 4
21-03-2012 дата публикации

Human alpha-defensin 5 antiviral active mutant polypeptide and preparation method and application

Номер: CN0101704886B
Автор: CHEN FANG, CHENG TIANMIN, SHEN MINGQIANG, SU YONGPING, WANG AIPING, WANG JUNPING, WANG SONG, FANG CHEN, TIANMIN CHENG, MINGQIANG SHEN, YONGPING SU, AIPING WANG, JUNPING WANG, SONG WANG
Принадлежит:

The invention relates to human alpha-defensin 5 (HD5) antiviral active mutant polypeptide and preparation method and application. The 21th glutamic acid in HD5 of the amino acid sequence of the mutant polypeptide can be replaced into arginine (E21R). The preparation method of the mutant polypeptide has two preparation methods, namely a solid-phase chemical synthesis method and a gene engineering preparation method. The HD5 mutant polypeptide of the invention has efficient antiviral activity under the conditions that serum exits or absents, and compared with parent HD5 polypeptide, the antiviral function of the invention is obviously improved. The HD5 mutant polypeptide of the invention is used for preventing viral infection, such as HSV, HPV, HIV and the like.

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Номер записи: 5
09-09-2009 дата публикации

Gene engineering preparation method of bioactive peptide containing human alpha defensin 5

Номер: CN0101525629A
Автор: WANG AIPING, WANG JUNPING, SU YONGPING, CHENG TIANMIN, WANG SONG, SHEN MINGQIANG, CHEN MO, AIPING WANG, JUNPING WANG, YONGPING SU, TIANMIN CHENG, SONG WANG, MINGQIANG SHEN, MO CHEN
Принадлежит:

The invention relates to a gene engineering preparation method of bioactive peptide containing human alpha defensin 5 and discloses a method for constructing expression vector of bioactive peptide gene containing human alpha-defensin 5 and for screening and fermenting in high density transformed yeast cloning strain thereof and the method for separating and purifying the bioactive peptide in fermentation supernatant. The invention also discloses the application of the bioactive peptide containing human alpha defensin 5 in preparing polypeptide medicine. The invention is applicable to realization of high efficiency fermentation expression through simple operation in the industrialized production scale and low-cost and high-efficiency purification and preparation of the bioactive peptide containing human alpha defensin 5 capable of highly effectively killing multiple pathogenetic bacteria and resisting virus such as HPV.

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Номер записи: 6
02-07-2008 дата публикации

Self blood plasma skin experimental approach for detecting chronic urticaria

Номер: CN0101209212A
Автор: SUN RENSHAN, LIU RONGQING, CHEN XIAOHONG, CHENG TIANMIN, WU JINJIN, YE QINGYI, DIAO QINGCHUN, HUANG XIUYING, YANG YADONG, BAO HONG, RENSHAN SUN, RONGQING LIU, XIAOHONG CHEN, TIANMIN CHENG, JINJIN WU, QINGYI YE, QINGCHUN DIAO, XIUYING HUANG, YADONG YANG, HONG BAO
Принадлежит:

The invention relates to a self-plasma and skin test method for detecting chronic urticaria, which has the following steps: (1) the peripheral blood of the patient is taken according to the allowable dosage of the usual skin tests and is added in a test tube containing blood anticoagulant; (2) the plasma is separated centrifugally; (3) one twentieth of the centrifugally separated plasma is absorbed to be injected in the forearm flexor skin, and the same volume of physiological saline is taken to be injected in the opposite side of the forearm flexor of the same patient, so as to carry out a control test; (4) the test results are observed after 30 minutes. The invention can greatly shorten the waiting time of the results of the patients, and the test results are accurate, so the invention can be used for clinically replacing self-serum skin test so as to carry out the test of the specific anti-IgE receptor autoantibodies with high affinity.

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Номер записи: 7
20-04-2011 дата публикации

Application of near infrared fluorescent chemical in lymphaden imaging and angiogram

Номер: CN0101574529B
Автор: SHI CHUNMENG, ZHANG CHAO, TAN XU, SU YONGPING, CHENG TIANMIN, CHUNMENG SHI, CHAO ZHANG, XU TAN, YONGPING SU, TIANMIN CHENG
Принадлежит:

The invention relates to an application of near infrared fluorescent chemical in lymphaden imaging and angiogram. The application of near infrared fluorescent chemical in lymphaden imaging and angiogram has the beneficial effects of simple operation, high marking efficiency, easy resolving and non toxic side effects, thus providing powerful technical support for clinician to effectively, accurately and safely resolving the lymphaden.

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Номер записи: 8
02-09-2009 дата публикации

Application of carbocyanine dye near infrared fluorescent compound

Номер: CN0101518528A
Автор: CHUNMENG SHI, YING ZHU, YONGPING SU, TIANMIN CHENG, SHI CHUNMENG, ZHU YING, SU YONGPING, CHENG TIANMIN
Принадлежит:

The invention discloses an application of a carbocyanine dye near infrared fluorescent compound in the preparation of a photosencitizer used for treating tumors or abnormal hyperplasia tissues, shown The invention discloses an application of a carbocyanine dye near infrared fluorescent compound in the preparation of a photosencitizer used for treating tumors or abnormal hyperplasia tissues, shown in formula I or II, wherein X is selected from iodine, chlorine, bromine, alkyl sulfide (OSO2-alkyl), BF4 or ClO4; R1 is selected from chlorine or bromine; R2 is selected from hydrogen, alkyl, hydroxyin formula I or II, wherein X is selected from iodine, chlorine, bromine, alkyl sulfide (OSO2-alkyl), BF4 or ClO4; R1 is selected from chlorine or bromine; R2 is selected from hydrogen, alkyl, hydroxyl group (-OH), carboxyl (-COOH), aryl, aromatic alkyl, alkyl sulfonate, alkyl carbonate and alkyl amine; and n is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, l1 or 12.l group (-OH), carboxyl (-COOH), aryl, aromatic ...

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Номер записи: 9
04-03-2009 дата публикации

Application of human transcription co-activate factor PC4 in preparations for preparing, diagnosing, curing or preventing tumor

Номер: CN0101377487A
Автор: CHUNMENG SHI, YING ZHU, YONGPING SU, TIANMIN CHENG, CHAO ZHANG, SHAOJUN WANG, YI PENG, XINZE RAN, SHI CHUNMENG, ZHU YING, SU YONGPING, CHENG TIANMIN, ZHANG CHAO, WANG SHAOJUN, PENG YI, RAN XINZE
Принадлежит:

The invention relates to the application of human transcriptional co-activator PC4 in preparing a preparation for diagnosing, treating or preventing tumors, particularly, the preparation for the diagnosis, the treatment or the prevention of the tumors is a preparation for diagnosing, treating or preventing the tumors from replasing and transforming, or a preparation for diagnosing, treating or preventing stem sells from malignant transforming. The preparation for diagnosing, treating or preventing the tumor comprises a preparation for diagnosing, treating or preventing prostate cancer, breastcancer or lung cancer. The result of the invention shows that human transcriptional co-activator PC4 genes are strongly expressed in various human tumor tissues such as the lung cancer, the breast cancer, the prostate cancer, and the like. The human transcriptional co-activator PC4 genes can be used for detection marker genes of various tumors, particularly, can be taken as warning marker molecules ...

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Номер записи: 10