Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 4. Отображено 4.
28-04-2023 дата публикации

GIP and GLP-1 dual-receptor agonist polypeptide compound and application thereof

Номер: CN116023444A
Автор: LUO QIANDONG, GUO PEILIANG, ZHANG GAOXIA, CAI JUNJIE, HOU SHIXING, ZHOU YOU, TAN YONGPING, WANG YUANLAN
Принадлежит:

The invention relates to the field of medicines, in particular to a GIP and GLP-1 dual-receptor agonist polypeptide compound and application thereof. Particularly, amino acid substitution is introduced, and fatty acids with different lengths are connected to the 20th lysine residue through PEG/AEA modification, so that the stability of the compound is improved, the in-vivo action time is prolonged, and the compound has the efficacy of reducing blood sugar and losing weight, can be used as an effective raw material for preparing medicines for treating or preventing diabetes, and has a wide application prospect. The traditional Chinese medicine composition can also be used for preparing weight-losing medicines or medicines for treating non-alcoholic steatohepatitis.

Подробнее
Номер записи: 1
06-08-2014 дата публикации

Automatic blackboard eraser

Номер: CN103963522A
Автор: LIANG JIANZHI, ZHAN NIANYUAN, XIE XIANGQIANG, LONG DANNING, ZHANG HAIYAN, HE CUI, YANG MING, LI JIANXIN, TAN YONGPING
Принадлежит:

The invention discloses an automatic blackboard eraser which comprises a rolling erasing mechanism, a rolling shaft, a first drive device, a second drive device and a dust removal device. The rolling erasing mechanism comprises a rolling shaft frame. The rolling shaft is rotatably arranged on the rolling shaft frame, and a brush is arranged around the rolling shaft. The first drive device comprises a guide rail arranged on one side of a blackboard and a screw on the other side of the blackboard, one end of the screw is connected with a first motor, one end of the rolling shaft frame is connected with a screw nut, the screw nut is connected with a screw in a matched mode, and the other end of the rolling shaft frame is arranged on the guide rail in a sleeved mode. The second drive device is connected with the rolling shaft. The automatic blackboard eraser is convenient to use, erasing speed is high, no dust flies when the blackboard eraser is used, damage of the dust to human bodies is avoided ...

Подробнее
Номер записи: 2
04-08-2023 дата публикации

Synthesis method of urease inhibitor impurity B

Номер: CN116535438A
Автор: SHI YUHUA, GAN HUAQIANG, YU YIZHONG, GAO YU, GU XUANYU, TAN YONGPING
Принадлежит:

The invention discloses a synthesis method of a urease inhibitor impurity B. The synthesis method comprises the following steps: adding a solvent into a reaction bottle under the protection of nitrogen, controlling the temperature to be-10 to 30 DEG C, simultaneously, respectively and slowly dropwise adding n-butylamine and a thiophosphoryl chloride solution, keeping the temperature to be-10 to 30 DEG C, and stirring for 0.5 to 3 hours; cooling the system to-60 to-10 DEG C, slowly introducing ammonia gas, slowly heating to 0-30 DEG C, then slowly adding water, extracting and layering, concentrating an organic phase, and performing column chromatography separation to obtain the urease inhibitor impurity B. The synthesis method disclosed by the invention is short in reaction step and simple and convenient to operate, and the high-purity urease inhibitor impurity B can be rapidly obtained.

Подробнее
Номер записи: 3
09-05-2023 дата публикации

Synthesis method of urease inhibitor impurity A

Номер: CN116082395A
Автор: SHI YUHUA, GAN HUAQIANG, YU YIZHONG, GAO YU, GU XUANYU, TAN YONGPING
Принадлежит:

The invention discloses a synthesis method of a urease inhibitor impurity A. The synthesis method comprises the following steps: adding thiophosphoryl chloride and a solvent into a reaction bottle under the protection of nitrogen, slowly dropwise adding n-butylamine under the condition of controlling the temperature to be-40-0 DEG C, slowly heating to 0-30 DEG C, keeping the temperature to react for 0.5-3 hours, then slowly adding water, extracting and layering, concentrating an organic phase, and performing column chromatography separation, thereby obtaining the urease inhibitor impurity A, the urease inhibitor impurity A is obtained. The synthesis method disclosed by the invention is short in reaction step and simple and convenient to operate, and the high-purity urease inhibitor impurity A can be rapidly obtained.

Подробнее
Номер записи: 4