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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 7. Отображено 7.
28-04-2023 дата публикации

GIP and GLP-1 dual-receptor agonist polypeptide compound and application thereof

Номер: CN116023444A
Автор: LUO QIANDONG, GUO PEILIANG, ZHANG GAOXIA, CAI JUNJIE, HOU SHIXING, ZHOU YOU, TAN YONGPING, WANG YUANLAN
Принадлежит:

The invention relates to the field of medicines, in particular to a GIP and GLP-1 dual-receptor agonist polypeptide compound and application thereof. Particularly, amino acid substitution is introduced, and fatty acids with different lengths are connected to the 20th lysine residue through PEG/AEA modification, so that the stability of the compound is improved, the in-vivo action time is prolonged, and the compound has the efficacy of reducing blood sugar and losing weight, can be used as an effective raw material for preparing medicines for treating or preventing diabetes, and has a wide application prospect. The traditional Chinese medicine composition can also be used for preparing weight-losing medicines or medicines for treating non-alcoholic steatohepatitis.

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Номер записи: 1
11-03-2009 дата публикации

Preparation method of (R)-(+)-N-propargyl-1-indan amines

Номер: CN0101381314A
Автор: QIANDONG LUO, JIAN XU, YONG ZHANG, LUO QIANDONG, XU JIAN, ZHANG YONG
Принадлежит:

The invention discloses a method for preparing rasagiline which has simple and convenient operation and is suitable for industrialized production. In the method, primary amine group on 1-indan amine is protected by o-Nos, and the 1-indan amine removes the protecting group after the 1-indan amine is substituted by propargyl chloride (or propargyl bromide); compared with the prior method, two steps of reactions are added in the method, but after the 1-indan amine is protected by the o-Nos, the reaction specificity of the 1-indan amine and the propargyl chloride (or the propargyl bromide) is greatly improved; and the protecting group can be easily removed after reaction without other side effects, so a single product is generated. Besides, raw materials and reaction reagent used in the method is cheap and easily obtained. The method has the advantages of simple and easy operation, mild reaction condition, easy control, good reaction selectivity, total yield improvement and cost reduction, ...

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Номер записи: 2
30-03-2018 дата публикации

Drying cabinet of even heating

Номер: CN0207163141U
Автор: LUO QIANDONG, HU DEYIN
Принадлежит: CHENGDU FURUCON BIOLOGICAL TECH CO LTD, CHENGDU FURUCON BIOLOGICAL TECHNOLOGY CO., LTD.

The utility model discloses a drying cabinet of even heating, including drying cabinet and inert gas device, the drying cabinet pass through the gas supply line with the inert gas device is connected,be provided with the isolation valve door on the gas supply line, adjusting valve and manometer, still be connected with gas -exhaust branch pipe on the gas supply line, the drying cabinet includes and is located the box the heating pipe of bottom half and lateral wall is located the dry mechanism of rotation at box middle part lies in the backup pad of rotatory dry mechanism below, and lie in ventilation mechanism in the backup pad, the gas supply line end is located the below of the heating pipe of bottom half, the backup pad is located the top of the heating pipe of bottom half, the dryingcabinet top is provided with sealing door. Through the rational design to drying cabinet of even heating, make the gas that gets into the drying cabinet not contain impurity, it is more even than theheating ...

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Номер записи: 3
26-03-2014 дата публикации

Synthesis route of [2-[2-(Fmoc-amino) ethoxy] ethoxy] acetic acid

Номер: CN103664701A
Автор: LUO QIANDONG, HU DEYIN
Принадлежит:

The invention discloses a synthesis route and a refining method for a key intermediate [2-[2-(Fmoc-amino) ethoxy] ethoxy] acetic acid of an anti-AIDS drug. [2-[2-(Fmoc-amino) ethoxy] ethoxy] acetic acid is a polypeptide separating agent. According to the method, the raw material cost is low, the yield is high, and the finished product content is higher than 99%.

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Номер записи: 4
15-07-2015 дата публикации

Peptide and protein pegylation agent synthesis method

Номер: CN104774161A
Автор: LUO QIANDONG, HU DEYIN
Принадлежит:

The present invention discloses a synthesis route and an operation method of a peptide and protein pegylation agent, wherein the pegylation agent is used for polypeptides and drug structure modification, the raw materials of the method are cheap, and the amount of the polyethylene glycol can be defined.

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Номер записи: 5
20-04-2011 дата публикации

New preparation method of (R)-2-acetamido-N-benzyl-3-methoxy propionamide (lacosamide)

Номер: CN0102020585A
Автор: Luo Qiandong
Принадлежит:

The invention relates to a new preparation method of (R)-2-acetamido-N-benzyl-3-methoxy propionamide (lacosamide), which has the advantages of simple operation and is suitable for industrialized production. Boc-serine is utilized to form lactone, the O-methylation is carried out directly without adding any catalyst, and has the advantages of single reaction, mild condition, easy control and good market prospect.

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Номер записи: 6
08-10-2003 дата публикации

Technique of preparing extract product of ÔÇÿLiangtoujianÔÇÖ and its application in preparing medication of treating cancer

Номер: CN0001446818A
Автор: LI WENJUN, LUO QIANDONG, SUN QIAN, WENJUN LI, QIANDONG LUO, QIAN SUN
Принадлежит:

A process for preparing the extract of amphioxea includes extracting in alkali solution, neutralizing with acid, concentrating, depositing in alcohol and refining. Its advantage is high purity and output rate of raddeanin A. Its application in preparing anticancer medicine is also disclosed.

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Номер записи: 7