13-03-2014 дата публикации
Номер: US20140072577A1
Herein provided are compositions, methods of manufacture and methods of use pertaining to anti-alpha toxin antibodies and fragments. 184-. (canceled)85Staphylococcus aureus. An isolated antibody or antigen-binding fragment thereof , wherein the isolated antibody or antigen-binding fragment thereof immunospecifically binds to a alpha toxin polypeptide and comprises:(a) a VH CDR1 comprising the amino acid sequence of SEQ ID NO: 7, 10, 13 or 69;(b) a VH CDR2 comprising the amino acid sequence of SEQ ID NO: 8, 11, 14, 17, 70 or 75;(c) a VH CDR3 comprising the amino acid sequence of SEQ ID NO: 9, 12, 15, 18, 16, 65, 66, 67, 71, 72, 76 or 78;(d) a VL CDR1 comprising the amino acid sequence of SEQ ID NO: 1 or 4;(e) a VL CDR2 comprising the amino acid sequence of SEQ ID NO: 2, 5, 73 or 77; and(f) a VL CDR3 comprising the amino acid sequence of SEQ ID NO: 3, 6, 64, 68 or 74.86. The antibody or antigen binding fragment of claim 85 , wherein the VH CDR1 claim 85 , VH CDR2 claim 85 , VH CDR3 claim 85 , VL CDR1 claim 85 , VL CDR2 and VL CDR3 correspond to the amino acid sequences of SEQ ID NOs: 7 claim 85 , 8 claim 85 , 9 claim 85 , 1 claim 85 , 2 and 3; SEQ ID NOs: 10 claim 85 , 11 claim 85 , 12 claim 85 , 1 claim 85 , 2 and 3; SEQ ID NOs: 13 claim 85 , 14 claim 85 , 15 claim 85 , 4 claim 85 , 5 and 6; SEQ ID NOs: 7 claim 85 , 17 claim 85 , 18 claim 85 , 1 claim 85 , 2 and 3; SEQ ID NOs: 7 claim 85 , 8 claim 85 , 16 claim 85 , 1 claim 85 , 2 and 64; SEQ ID NOs: 7 claim 85 , 8 claim 85 , 65 claim 85 , 1 claim 85 , 2 and 64; SEQ ID NOs; 7 claim 85 , 8 claim 85 , 66 claim 85 , 1 claim 85 , 2 and 64; SEQ ID NOs: 7 claim 85 , 8 claim 85 , 67 claim 85 , 1 claim 85 , 2 and 68; SEQ ID NOs: 7 claim 85 , 8 claim 85 , 67 claim 85 , 1 claim 85 , 2 and 64; SEQ ID NOs: 7 claim 85 , 8 claim 85 , 78 claim 85 , 1 claim 85 , 2 and 64; SEQ ID NOs: 7 claim 85 , 8 claim 85 , 65 claim 85 , 1 claim 85 , 2 and 68; SEQ ID NOs: 69 claim 85 , 70 claim 85 , 71 claim 85 , 1 claim 85 , 2 and 68; SEQ ID NOs: ...
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