SYSTEM AND PROCESS FOR THE REEMISSION OF DATA OF UPLINK IN A COMMUNICATION SYSTEM HAVE ACCESS MULTIPLE BY DISTRIBUTION BY CODE

PROCEEDED WITH GENERATION Of a RADIATION WISHED WAVELENGTHS, ETDISPOSITIF ASSOCIATES

MAGNETIC CERAMIC COMPOSITION FOR the USE IN DEVICES HAS MICROWAVES, MAGNETIC CERAMICS FOR the USE IN DEVICES HAS MICROWAVES AND ITS METHOD OF PREPARATION

TOGETHER OF FRONT PANEL FOR MICROWAWE OVEN AND PROCEEDED Of ASSEMBLY OF THIS UNIT

Apparatus of formation of image.

PLUG STRUCTURE OF THE CONTAINER.

PLUG STRUCTURE OF THE CONTAINER.

La présente invention concerne la structure de bouchage d'un récipient, qui est accouplé avec ledit récipient pour fermer/ouvrir ledit récipient. La structure de bouchon comprend un bouchon interne ayant cylindrique et accouplé avec une partie d'extrémité supérieure du récipient pour ouvrir/fermer le récipient, un bouchon externe cylindrique et inséré dans la surface extérieure du bouchon interne, de telle sorte que le bouchon externe est accouplée avec le bouchon interne, un élément inséré dans le bouchon externe et le bouchon interne et une unité amovible afin d'accoupler de manière fixe le composant avec le bouchon interne ou le bouchon externe ou séparer le composant avec le bouchon interne ou le bouchon externe sans séparer le bouchon interne ou le bouchon externe du récipient. En conclusion, le bouchon peut ouvrir/fermer le récipient de manière de fixer l'élément au bouchon ou de le démonter du bouchon sans séparer le bouchon du récipient.

EARTHQUAKE RESISTANT LID FOR CONTAINER TRANSPORTATION OF NUCLEAR FUEL ASSEMBLY AND SHIPPING CONTAINER FOR NUCLEAR FUEL ASSEMBLIES

METHOD FOR INTEGRATED MONITORING FOR A NUCLEAR DEVICE AND SYSTEM USING SAME

ARRAY SUBSTRATE, MANUFACTURING METHOD THEREOF AND LIQUID CRYSTAL DISPLAY DEVICE HAVING THE SAME

DISPLAY DEVICE AND METHOD OF MAKING SAME.

VERTICAL VIBRATOR

NANOPARTICULE HETERONUCLEAIRE OF RADIOISOTOPE HAS STRUCTURE NOYAU-COQUE AND ITS METHOD OF PREPARATION.

L'invention concerne une nanoparticule hétéronucléaire de radio-isotope à structure noyau-coque et son procédé de préparation. La nanoparticule hétéronucléaire de radio-isotope à structure noyau-coque comprend : un noyau contenant deux radio-isotopes différents choisis parmi198Au,63Ni,110mAg,64Cu,60Co,192Ir et103Pd ; et une coque de SiO2 entourant le noyau. La nanoparticule hétéronucléaire de radio-isotope à structure noyau-coque peut être utilisée comme traceur pour détecter une variation de rapport volumique ou pour évaluer les caractéristiques du comportement d'une ressource en eau, sur la base d'informations concernant le rapport de phase dans l'écoulement d'un fluide à plusieurs phases existant dans un procédé qui est mis en œuvre dans des conditions extrêmes telles qu'une température élevée et/ou une pression élevée.

COMMUNICATION SYSTEM FOR ENGINE HAS TURBINE

Système de communication (30), comprenant un capteur (25) servant à mesurer un état à un point de mesure concerné (20) défini sur un rotor (12) d'une turbine (10), à une certaine distance radiale d'un axe central (122) autour duquel peut tourner le rotor (12), des câblages disposés sur le rotor (12), à une certaine distance radiale de l'axe central (122), les câblages comprenant un premier tronçon de câblages (40) relié au capteur (25), un second tronçon de câblages (60) et une première connexion (50) par laquelle les premier et second tronçons de câblages (40, 60) peuvent être connectés, une seconde connexion (70) par laquelle le second tronçon de câblages (60) transmet un signal reflétant l'état détecté à un élément d'enregistrement non rotatif (75), et un module de compensation (65) de température disposé sur le second tronçon de câblage (60) pour régler le signal.

DISPLAY DEVICE, DEVICE OF REMOTE CONTROL AND RELATED FUNCTION OF ORDER

Un dispositif de commande à distance est proposé. Le dispositif de commande à distance destiné à sélectionner l'un d'une pluralité de modes d'exploitation d'un dispositif d'affichage externe étant exploitable entre un mode de pointage et un mode gestuel, associé au dispositif de commande à distance. Le dispositif de commande à distance inclut une unité de génération en sortie destinée à générer en sortie des informations connexes au dispositif de commande à distance, vers le dispositif externe, une unité de détection destinée à détecter le mouvement du dispositif de commande à distance, une unité de génération d'informations de mouvement destinée à générer des informations de mouvement sur la base du mouvement détecté du dispositif de commande à distance, une unité de changement de mode d'exploitation destinée à fournir des informations connexes à un mode d'exploitation, en vue de modifier le mode d'exploitation du dispositif externe exploitable entre le mode de pointage et le mode gestuel ...

Decoration kit type door assembly for e.g. refrigerator, has handle integral part of one of left or right side metallic covers, where handle has curved plate extending in longitudinal direction of cover in order to define hollow of cover

L'invention concerne un ensemble porte (100) du type à kit de décoration destiné à un produit électronique. Dans l'ensemble porte (100) comprenant des plaques de porte (10) et des couvercles latéraux gauche et droit (20a et 20b) couplés aux deux côtés des plaques de porte (10), une poignée (22b) de porte d'ouverture/de fermeture fait partie intégrante de l'un des couvercles latéraux gauche et droit (20a et 20b), entraînant une réduction des coûts de fabrication. De même, lorsque la poignée (22b) de porte du couvercle latéral a la forme d'une partie en creux (23b') définie intégralement dans le couvercle latéral de manière à ne pas faire saillie vers l'extérieur du couvercle latéral, l'ensemble porte (100) résultant donne une apparence extérieure satisfaisant aux demandes d'esthétisme des consommateurs.

Display device e.g. LCD device, has signal line connecting another signal line to driving circuit, where signal lines are formed in conductive-layer structure by interposing insulation layer between lower and upper lines

Un dispositif d'affichage comprend un circuit de pilotage formé sur un substrat ; au moins une première ligne de signaux (103) comportant des lignes inférieure (100) et supérieure (102) se chevauchant entre elles avec une couche d'isolation intercalée entre elles, la première ligne de signaux (103) étant formée au niveau d'un côté du circuit de pilotage ; et au moins une deuxième ligne de signaux (201) pour raccorder la première ligne de signaux (103) au circuit de pilotage. Application à un dispositif d'affichage à cristaux liquides (LCD) empêchant des défauts provoqués par déconnexion d'une ligne de signaux.

OXIDATIVE DECONTAMINATION REAGENT FOR REMOVING RADIOACTIVE DENSE OXIDE LAYER ON A METAL SURFACE AND OXIDATIVE DECONTAMINATION METHOD USING THE SAME

La présente invention concerne un réactif de décontamination oxydative pour l'élimination de la couche d'oxyde radioactif dense sur la surface métallique, le réactif comprenant un agent d'oxydation, un ion métallique, et un acide inorganique. Le réactif de décontamination oxydative de la présente invention est caractéristiquement préparé par ajout d'un ion métallique au réactif de décontamination oxydative classique contenant un agent d'oxydation et un acide inorganique. Lorsque le réactif de décontamination oxydative de la présente invention est utilisé, le potentiel électrique des parties métalliques du système primaire de la centrale nucléaire peut être régulé comme un potentiel passif en raison de l'ion métallique ajouté pendant la décontamination oxydative de la partie métallique primaire de la centrale nucléaire. Il est par conséquent possible d'inhiber la corrosion locale tout en réduisant significativement les déchets secondaires par le maintien du potentiel électrique de la partie ...

MULTIPLEXED MICROVOLT SENSOR SYSTEMS

L'invention concerne des systèmes et des procédés à capteur microvolt multiplexé. Un exemple de système peut comprendre une source lumineuse à impulsions, un premier segment optique guide d'onde couplé en fonctionnement à la source lumineuse à impulsions, un circulateur optique (104) contenant un premier port, un deuxième port et un troisième port, le premier port étant couplé en fonctionnement au premier segment guide d'onde optique (151), un deuxième segment guide d'onde optique (152) couplé en fonctionnement au deuxième port du circulateur optique (104), et une matrice d'éléments de détection (110). Chacun des éléments de détection peut comprendre un détecteur (230) et un modulateur électro-optique, le modulateur électro-optique (220) étant couplé en fonctionnement au deuxième segment guide d'onde optique. L'exemple de système peut comprendre en outre un troisième segment guide d'onde optique (153) couplé en fonctionnement au troisième port du circulateur optique (104), un interféromètre ...

LED LIGHTING AND OF VENTILATION COMBINE

Conduit d'éclairage et de ventilation combinés, comprenant au moins deux tuyaux optiques (110) à l'intérieur desquels de l'air est amené à passer, de la lumière se propageant dans les au moins deux tuyaux optiques (110) en étant totalement réfléchie, et un élément de raccordement (120) raccordant les uns aux autres les au moins deux tuyaux optiques, l'élément de raccordement (120) ayant un embout de raccordement (125) destiné à être raccordé à un tuyau (30). Une partie supérieure du conduit est noyée dans un faux-plafond (20) sous un vrai plafond (10) et une partie inférieure est exposée sous le faux-plafond (20). Selon une autre possibilité, l'ensemble du conduit d'éclairage et de ventilation combinés est installé de manière à être exposé sous le faux-plafond (20). Lorsque l'air et la lumière se propagent dans le conduit d'éclairage et de ventilation combinés, la lumière est totalement réfléchie à l'intérieur des tuyaux optiques (110) afin d'éclairer un espace intérieur et l'air est fourni ...

METHOD OF TREATING WASTE RADIOACTIVE ION EXCHANGE RESINS, AND APPARATUS THEREFOR

La présente invention concerne un procédé et un appareil de traitement de déchets de résines échangeuses d'ions contenant des radionucléides. La présente invention concerne également un procédé de traitement de déchets de résines échangeuses d'ions contenant des radionucléides par un traitement thermique par étapes et un appareil pour mettre en œuvre ledit procédé.

ELASTOMER COMPOUNDS

Il est décrit ici des composés élastomères comprenant : au moins un élastomère qui est résistant à la chaleur pendant 70 h à 100°C de sorte que le au moins un élastomère présente au moins une des propriétés suivantes choisies parmi : (a) une modification de dureté d'après duromètre d'au plus 15 points, (b) une modification de résistance à la traction d'au plus 40 %, et (c) une modification d'allongement à la rupture d'au plus 40 %. Le composé élastomère comprend de plus au moins un matériau à base de graphène présent dans une quantité de 0,01 pcc à 30 pcc par rapport au au moins un élastomère et au moins un noir de carbone présent dans une quantité de 15 pcc à 150 pcc par rapport au au moins un élastomère. Il est également décrit des procédés de fabrication de tels composés, et des articles comprenant des composés élastomères.

Farbzusammensetzung mit selbstständig Kratzer-beseitigenden Eigenschaften

Die Erfindung betrifft eine selbstständig Kratzer-wiederherstellende Farbzusammensetzung, die eine verkürzte Trocknungszeit und eine verlängerte Topfzeit aufweist, und bezogen auf das Gesamtgewicht der Farbzusammensetzung ungefähr 3040 Gew.-% eines verzweigten Polyesterharzes; ungefähr 3040 Gew.-% eines Acryl-Polyol-Harzes; ungefähr 0,20,5 Gew.-% eines Reaktionskatalysators; und ungefähr 0,9909 Gew.-% eines Reaktionsverzögerers enthält.

Arzneimittelzusammensetzung zur Prophylaxe und Behandlung vorzeitigen Samenergusses

PROCESS TO DETECT a CRACK CROSSING the WALL Of a TUBE AND TO MEASURE LALONGUEUR OF the CROSSING CRACK

HEMISPHERICAL RESONATOR GYROSCOPE MILLIMETER WITH INTERNAL FORCE.

Processing method call signaling intelligent network service in an electronic communications system for long distance/a tandem.

PROCESS AND APPARATUS TO REDUCE THE POWER IN MEMORIES HIDING PLACE ETSYSTEME OF DATA PROCESSING COMPRISING OF MEMORIES CHACHES

FIBRE OF POLYETHYLENE NAPHTALATE OF HIGH STRENGTH

ORGANIC TRANSISTOR IN THIN LAYERS, DISPLAY DEVICE HAS LIQUID CRYSTALS USING THIS TRANSISTOR, AND THEIR MANUFACTORING PROCESS

METHOD OF PREPARING A NANOSTRUCTURE RADIOISOTOPE WITH A FRAMEWORK METAL-LIGAND AND APPLICATION THEREOF

DEVICE ELECTROLUMINESCENT AND MANUFACTORING PROCESS OF THIS ONE

Dispositif électroluminescent comprenant un premier substrat (300) et un second substrat (350), chaque substrat étant subdivisé entre une région de contact (A) et une région de pixel (B). Selon l'invention, les éléments conducteurs positionnés dans chacune de la région de contact (A) et de la région de pixel (B) du premier substrat peuvent être sensiblement de la même hauteur, permettant de raccorder la couche de contact du premier substrat à une seconde ligne métallique du second substrat. Application à la fabrication d'un dispositif électroluminescent organique (OLED) dans lequel des transistors à couches minces (TFT) sont d'abord formés sur un substrat, puis des diodes électroluminescentes sont formées sur le transistor à couches minces.

OPTICAL AMPLIFIER HAS WEAK NOISE AND OPTICAL COMMUNICATION SYSTEM USING It

PROCESS Of ENERGY SAVING FOR AIR-CONDITIONER

TRANSMITTER, RECEIVER AND THEIR PROCESS IN A COMMUNICATION SYSTEM WITH THE HUMAN BODY.

Récepteur dans un système de communication avec le corps humain, comprenant des électrodes réceptrices (1 à n) comprenant une trame de transmission comprenant des trames de commande (300) et des trames de données (400), des premier et deuxième commutateurs connectés aux électrodes réceptrices (1 à n), une unité de commande de commutation (250) des premier et deuxième commutateurs (211, 212) pour connecter les électrodes réceptrices (1 à n) aux premier et deuxième commutateurs en réponse à chaque trame de commande (300), une unité de traitement de signal (214) en sortie des premier et deuxième commutateurs, une unité de détection de préambule (230) pour générer des valeurs de corrélation de préambule pour le premier préambule, et une unité de traitement de valeur de corrélation (240) commandant l'unité de commande de commutation (250) pour sélectionner des paires d'électrodes réceptrices (1 à n) finales sur la base des valeurs de corrélation de préambule.

LIGHT GUIDING PANEL AND LIQUID CRYSTAL DISPLAY DEVICE

METHOD OF OXIDE DISPERSION STRENGTHENED METAL MATERIAL USING A LASER

APPARATUS OF AUXILIARY CONDENSATION PASSIVE OF NUCLEAR PLANT

Un appareil de condensation auxiliaire passif d'une centrale nucléaire comprend une unité de génération de vapeur (110) configurée pour chauffer de l'eau (3) qui y est délivrée en une vapeur (5) par une chaleur produite lors du fonctionnement d'un réacteur nucléaire, une unité d'échange de chaleur refroidie par eau (120) reliée à l'unité de génération de vapeur (110) et configurée pour stocker une eau de refroidissement (1) afin de condenser la vapeur (5) délivrée par l'unité de génération de vapeur (110), et un réservoir de séparation vapeur-eau (140) comprenant un côté relié à l'unité d'échange de chaleur refroidie par eau (120) et l'autre côté relié à l'unité de génération de vapeur (110), un mélange d'eau (3) et de vapeur (5) délivré par l'unité d'échange de chaleur refroidie par eau (120) étant séparé en eau (3) et en vapeur (5) afin de délivrer seulement l'eau (3) à l'unité de génération de vapeur (110) .

CONDENSING APPARATUS AUXILIARY PASSIVE NUCLEAR POWER PLANT

DISPLAY DEVICE HAS Touchscreen

MACHINE AND a METHOD FOR GRINDING a GRID Of SPACING Of a UNIT HAVE FUEL NUCLEAR

La présente invention propose une machine et un procédé pour meuler une grille d'espacement d'un ensemble à combustible nucléaire. La machine comprend une unité de support de grille d'espacement, un premier robot à coordonnées rectangulaires pour meuler une surface externe de la grille d'espacement, un deuxième robot à coordonnées rectangulaires pour meuler un coin de la grille d'espacement et une unité de commande. L'unité de support de grille d'espacement comprend un gabarit de support sur lequel la grille d'espacement est installée et maintenue, et une table circulaire rotative qui est couplée au gabarit de support pour faire tourner le gabarit de support. Les premier et deuxième robots à coordonnées rectangulaires sont prévus dans des positions prédéterminées adjacentes à l'unité de support de grille d'espacement. L'unité de commande commande l'unité de support de grille d'espacement, les premier et deuxième robots à coordonnées rectangulaires et tous les programmes nécessaires pour ...

SYSTEM OF FOLLOW-UP IN Real-time Of a FUEL SWIMMING POOL EXHAUSTS AND PROCEEDED FOR THIS ONE

La présente invention se rapporte à un système de surveillance en temps réel d'une piscine de combustible épuisé, le système comportant : une unité de détection (100) configurée pour détecter de l'information de condition ; une unité de stockage d'entrée (200) configurée pour recevoir et stocker l'information de configuration d'un combustible usagé ; une unité d'opération et de détermination (300) configurée pour calculer l'information de condition courante du combustible usagé en utilisant l'information de condition détectée par l'unité de détection (100) et l'information de configuration et l'information d'historique stockées dans l'unité de stockage d'entrée (200) et configurée pour déterminer un niveau de risque en comparant l'information de condition courante à la valeur limite correspondant au niveau de risque ; et une unité d'affichage (400) .

GYROSCOPE HAS HEMISPHERICAL RESONATOR MILLIMETRE-LENGTH HAS INTERNAL DEVICE OF FORCE.

Le gyroscope à résonateur hémisphérique millimétrique à dispositif de force interne (GRHm) est un gyroscope petit, de faible coût et à hautes performances. Il peut présenter une conception extrêmement simplifiée ne comportant, dans un mode de réalisation du présent procédé et du présent appareil, que cinq pièces principales au total, la plupart des pièces remplissant de multiples fonctions. Le procédé et l'appareil dans un mode de réalisation peuvent comporter : un résonateur (108) et un corps (105) couplé fonctionnellement au résonateur, le corps simple comportant de manière intégrée des électrodes, une unité de support d'électrodes (107) , une bague soudée et une pluralité de broches (112) électriquement conductrices, la pluralité d'électrodes étant couplée fonctionnellement aux broches électriquement conductrices.

Verfahren zum Wiederauffinden von Bildtexturen und Vorrichtung dafür

DATENTRÄGERKASSETTE UND DATENTRÄGERLAUFWERKVORRICHTUNG DAMIT

Verfahren und Vorrichtung zum Durchführen von Handover zwischen Kernnetzwerkeinheiten in einem paketvermittelten Netzwerk

Streptococcus pneumoniae-Antigene und Impfstoffe

Herstellung von hochfestem und hochschlagzähem Polypropylen/Nanoton/Kautschuk-Komposit unter Verwendung einer Kautschuk/Nanoton-Vormischung

Offenbart hier sind eine Zusammensetzung aus einer Kautschuk/Nanoton-Vormischung und ein Verfahren zur Herstellung einer hochfesten und hochschlagzähen Zusammensetzung aus einem Polypropylen/Nanoton/Kautschuk-Komposit unter Verwendung der vorstehenden Zusammensetzung. Insbesondere ist ein Verfahren zur Herstellung einer Kautschuk/Nanoton-Vormischung unter Verwendung eines modifizierten Polymers mit einem hohen Gehalt an Maleinsäureanhydrid als Verträglichmacher bereitgestellt. Gemäß dem offenbarten Verfahren wird eine Nanoton-Vormischung auf Kautschukbasis bereitgestellt und diese kann bei Zugabe zu Propylen unter vorteilhafter Verbesserung der Schlagzähigkeit eine durch Kautschukzugabe verursachte Abnahme des Biegemoduls verhindern. Zudem kann unter Verwendung eines mit Maleinsäureanhydrid gepfropft-modifizierten Polymers mit einen hohen Gehalt an Maleinsäureanhydrid eine Zusammensetzung aus einer Kautschuk/Nanoton-Vormischung mit ausgezeichneter Dispergierbarkeit in Polymer erhalten werden ...

INTEGRATED CIRCUIT INCORPORATING A CIRCUIT TO CONTROL TRANSISTORS DEPUISSANCE GO UP ACCORDING TO A CONFIGURATION IN DEMI-PONT ALLOWING AN EXCESSIVE OSCILLATIONNEGATIVE OF THE NODE OF EXIT

METHOD FOR DETERMINING A SPEED LIMIT IN FORCE ON A ROAD TAKEN BY A MOTOR VEHICLE

DRUM TYPE WASHER.

METHOD AND APPARATUS FOR RETRANSMITTING DATA IN A MOBILE COMMUNICATION SYSTEM CDMA

APPARATUS FOR PASSIVE COOLING OF SPENT FUEL POOL

VIBRATOR LINEAR SMT

PROCESS OF POWER CONTROL DURING A TRANSFER WITHOUT CUT IN UNSYSTEME OF MOBILE COMMUNICATION

DRYER HAS VAPOR AND HAS HOT BREATH, AND ITS PROCESS OF ORDER.

PROGRAMMABLE APPARATUS TO DYNAMICALLY CONTROL THE VOLTAGE

La présente invention concerne un appareil programmable de commande dynamique de la tension, et plus particulièrement un appareil programmable de commande dynamique de la tension en mesure de commander dynamiquement la conversion de tension d'une unité de sortie en utilisant des données réglées dans des mémoires programmables, quand divers éléments d'informations détectés par une variété de capteurs montés dans un véhicule sont convertis en signaux électriques puis transmis.

Fabric e.g. clothes, treating e.g. drying, apparatus, has condensed water treating element treating condensed water that is formed under effect of condensation of vaporized humidity in storing space or air supplied by air supplying device

Est divulgué un appareil de traitement des tissus qui fournit de l'air chaud à un espace de logement (110) recevant des vêtements afin de sécher ces derniers. Cet appareil comprend une armoire (100) comprenant un espace de logement (110) pour recevoir des vêtements et une chambre de composants électriques (120) où sont installés un dispositif pourvoyeur d'humidité (140) pour vaporiser de la vapeur d'eau dans l'espace de logement (110) et un dispositif d'alimentation en air (130) pour fournir de l'air chaud ; et un élément de traitement de l'eau condensée pour traiter l'eau condensée formée par la condensation de la vapeur d'eau vaporisée dans l'espace de logement (110) ou de l'air chaud fourni par le dispositif d'alimentation en air (130). Par conséquent, cet appareil traite l'eau condensée formée dans l'espace (110) et empêche ainsi la formation de substances nocives pour l'organisme humain, comme la moisissure, dans cet espace (110).

Cloth treating e.g. refreshing, apparatus, has noise preventing device installed at level of inlet opening for avoiding noise generated inside equipment chamber and outside equipment chamber

Un appareil de traitement de vêtements (100) traitant des vêtements dans un état approprié pour être portés est décrit et comprend une armoire (101), un espace de réception (110) défini dans l'armoire pour recevoir des vêtements, des dispositifs de distribution d'air et d'humidité (130, 140) pour distribuer de l'air sec et de l'humidité dans l'espace de réception (110), respectivement, une chambre d'équipement (120) définie dans l'armoire (101) pour recevoir les dispositifs de distribution d'air chaud et de vapeur, la chambre d'équipement (120) comprenant un orifice d'admission (121) pour laisser l'air extérieur s'introduire dans la chambre d'équipement (120) à travers celui-ci pour refroidir les dispositifs de distribution d'air chaud et de vapeur, et un dispositif de prévention du bruit installé au niveau de l'orifice d'admission (121) pour empêcher le bruit généré dans la chambre d'équipement (120) d'être émis en dehors de la chambre d'équipement (120) à travers l'orifice d'admission ...

ROBOT Of INSPECTION OF the TYPE HAS TIGHTENING OF FINGERS FOR the TUBES Of a STEAM GENERATOR

Le robot d'inspection (R) comprend un module à déplacement avant ou arrière (10), un module à déplacement gauche ou droite (20), espacé du module à déplacement avant ou arrière (10), un module à dispositif d'inspection (30) installé sur le module à déplacement avant ou arrière (10) pour examiner l'intérieur de tubes de chauffe, et des modules de serrage (40) installés avec possibilité de déplacement vertical et horizontal et de rotation et comprenant une pluralité d'éléments de serrage à doigt, destinés à être insérés dans les tubes de chauffe par un mouvement vertical, de manière à serrer simultanément les tubes de chauffe. Grâce au déplacement avant ou arrière, au déplacement gauche ou droite et à la rotation des modules de serrage (40), le robot d'inspection (R) peut être déplacé librement pour examiner les tubes de chauffe, situés à différents emplacement, et peut serrer facilement les tubes de chauffe, ce qui permet d'obtenir un temps d'inspection réduit et une inspection stable.

Mobile terminal e.g. folding type mobile phone, for displaying broadcasted image, has control unit for controlling image such that image is displayed on screen-saver, and display for displaying image under control of control unit

Terminal mobile (100) comprenant un module de réception de diffusion (111) pour recevoir une image diffusée, une unité de commande (180) pour commander l'image diffusée de façon qu'elle soit affichée sur un écran de veille conformément à des informations d'affichage préétablies de l'écran de veille, et un afficheur (151) pour afficher l'image diffusée sous le contrôle de l'unité de commande (180). Puisqu'une image diffusée est affichée sur l'écran de veille, l'utilisateur peut y trouver du plaisir et de l'intérêt.

SYSTEM OF VENTILATION/ECLAIRAGE AND METHOD OF CORRESPONDING ORDER

Une conduite de ventilation/éclairage est décrite qui peut non seulement ventiler un espace intérieur, mais également peut éclairer l'espace intérieur. Un système de ventilation/éclairage utilisant la conduite de ventilation/éclairage et un procédé de commande pour le système de ventilation/éclairage sont également décrits. Le système de ventilation/éclairage comprend un dispositif de ventilation destiné à souffler de l'air, un dispositif d'alimentation en lumière destiné à fournir une lumière, une conduite de ventilation/éclairage destinée non seulement à guider l'air soufflé par le dispositif de ventilation pour ventiler un espace intérieur, mais également à réfléchir totalement la lumière pour éclairer un espace intérieur et un épurateur agencé dans la conduite de ventilation/éclairage.

PROCESSES AND CIRCUITS Of INPUT/OUTPUT OF DATA WHICH REVERSE LESBITS SELECTIVELY

IMAGE PROCESSING DEVICE, LEVELING DEVICE, DISPLAY SYSTEM INCLUDING THE SAME, AND CONTROL METHOD THEREOF

MACHINE HAS LINEN HAVING a VAPOR FEEDING ATTACHMENT

DISPLAY DEVICE

CARBON BLACK WITH AN STSA OF 80 TO 150 M2/G, AN OAN OF AT LEAST 180 ML/100G AND A COAN OF AT LEAST 110 ML/100G AND RUBBER COMPOUNDS INCORPORATING SAME

La présente invention concerne des noirs de carbone tels que des noirs de carbone de qualité renforcement hautement structurés. Le noir de carbone peut avoir les propriétés suivantes : une surface par épaisseur statistique (STSA) comprise entre 80 m2/g et 150 m2/g, un indice d'absorption d'huile (OAN) d'au moins 180 mL/100 g, et un indice d'absorption d'huile d'échantillons comprimés (COAN) d'au moins 110 mL/100 g. Elle concerne également des mélanges de caoutchouc qui incorporent le noir de carbone.

WEARABLE TERMINAL

L'invention concerne un terminal portable (100) comportant un corps principal (101), une carte principale (185) dans le corps principal (101), un premier pavé tactile (200) sur une surface arrière du corps principal (101), une carte flexible configurée pour connecter le corps principal (101) au premier pavé tactile (200), un bracelet (102) couplé au corps principal (101), enroulé autour d'un poignet d'un utilisateur pour immobiliser le corps principal (101) à la partie corporelle de l'utilisateur, un deuxième pavé tactile (210) sur l'autre surface d'une surface en contact avec la partie corporelle de l'utilisateur lorsque l'utilisateur porte le bracelet (102), une carte flexible ayant une extrémité connectée au deuxième pavé tactile (210) et l'autre à la carte principale (185), et un contrôleur (180) configuré pour extraire un électrocardiogramme par une mesure d'une différence de potentiels électriques de muscles corporels détectés par le premier pavé tactile (200) et le deuxième pavé ...

Mobile terminal i.e. mobile telephone, for use in mobile communication system to provide mobile communication system to e.g. local landowner, has middleware module transmitting processing result of mobile secured module function

Il est proposé un procédé et un dispositif pour fournir une fonction de module sécurisé mobile. En essayant d'effectuer une fonction de module sécurisé mobile pendant l'exécution d'une application sécurisée, un terminal mobile (100) génère une instruction correspondant à une fonction de module sécurisé mobile à effectuer, la transmet à un module d'identité universelle d'abonné (200), et acquiert un résultat de traitement d'une fonction de module sécurisé mobile sur la base d'un résultat de traitement d'une instruction de module sécurisé mobile correspondante reçue d'un module d'identité universelle d'abonné (200).

PORTE-SONDE FOR SENSOR OF ENGINE HAS TURBINE

Turbine (10) comprenant un organe ayant un corps, lequel peut tourner autour d'un axe géométrique central (122) d'un rotor et lequel est formé de manière à définir une cavité radialement très proche d'un point de mesure concerné (20) défini à une certaine distance radiale de l'axe géométrique central (122), un capteur (25) servant à mesurer un état au point de mesure concerné (20), un système de communication (30) par lequel des mesures d'états sont transmissibles du capteur (25) à un système d'enregistrement non rotatif et un porte-sonde insérable dans la cavité afin d'immobiliser le capteur (25) tout près du point de mesure concerné (20).

APPARATUS OF PASSIVE COOLING OF FUEL SWIMMING POOL EXHAUSTS

Un appareil destiné à refroidir une piscine de combustible épuisé (100) ayant un échangeur de chaleur (20) comprend une piscine d'eau de refroidissement (200) positionnée au-dessus de la piscine de combustible épuisé (100) ; un dispositif flottant (320) configuré pour être élevé en fonction d'un niveau d'eau d'une eau de refroidissement (110) dans la piscine de combustible épuisé (100) ; et un tuyau d'alimentation en eau de refroidissement de secours (300) configuré pour former un passage par l'intermédiaire duquel l'eau de refroidissement (110) de la piscine d'eau de refroidissement (200) est déplacée vers la piscine de combustible épuisé (100) et configuré pour comprendre une soupape à flotteur (310) qui ouvre ou ferme un passage d'écoulement de l'eau de refroidissement (110) en liaison avec la hauteur du dispositif flottant (320).

MACHINE AND METHOD FOR GRINDING A SPACER GRID OF A NUCLEAR FUEL ASSEMBLY

MANUFACTORING PROCESS Of a CELL Liquid crystal HAS

TOGETHER OF GRID FOR APPARATUS OF COLLECTION OF DUST HAS CYCLONE POURASPIRATEUR AND VACUUM CLEANER EQUIPS With SUCH a UNIT

SAFETY INJECTION SYSTEM USING A PASSIVE SAFETY INJECTION TANK

Curved display device e.g. LCD device, has a display screen having different curvatures with different radius of curvature that corresponds to radius of a circular arc which intersects with the corresponding segment of display screen

Un dispositif d'affichage (100) est fourni. Le dispositif d'affichage (100) inclut un écran d'affichage (DP1) destiné à afficher des images, et l'écran d'affichage (DP1) inclut différentes courbures au niveau de différents segments (HR1, HR2, HR3) de l'écran, chacune des différentes courbures présentant un rayon de courbure distinct, chaque rayon de courbure correspondant à un rayon d'un arc de cercle qui se rapproche d'une courbe croisant le segment correspondant (HR1, HR2, HR3).

DETERMINATION OF THE QUALITY OF RECEPTION IN A DEVICE OF RADIO COMMUNICATION.

Dispositif de communication radio, comprenant : un récepteur (202) configuré pour recevoir des signaux radio ; un circuit (204) de mesure configuré pour mesurer la qualité de réception de signaux radio reçus ; et une unité (206) de commande configurée pour commander le circuit (204) de mesure de façon à ce qu'une première mesure soit effectuée en utilisant la première largeur de bande de fréquences déterminée pour ainsi déterminer une première qualité de réception.

COMPOSITION OF RESERVE CHEMICALLY AMPLIFIEE CONTAINING OF SILICON

MOBILE TERMINAL AND METHOD FOR DISPLAYING SCREEN SAVER THEREOF

ZIRCONIUM ALLOY FOR IMPROVING OXIDATION RESISTANCE AT A VERY HIGH TEMPERATURE AND ITS MANUFACTURING METHOD.

APPARATUS INTENDS TO CHARGE A SPARE BATTERY BY USING A THERMOELECTRIC DEVICE OF GENERATION IN THE NUCLEAR PLANT

La présente invention se rapporte à un appareil destiné à charger une batterie de secours (300), qui délivre une alimentation de secours à un appareil de refroidissement de cœur de secours comprenant une pompe électrique ou une pompe à vapeur, l'appareil comportant : un dispositif de génération thermoélectrique (100) configuré pour détecter une chaleur de désintégration et une chaleur résiduelle produites dans une centrale nucléaire et configurée pour convertir la chaleur détectée en énergie électrique ; une unité de conversion d'énergie électrique (200) reliée au dispositif de génération thermoélectrique (100) pour sortir un courant généré dans le dispositif de génération thermoélectrique (100) sous forme d'une tension constante ; et la batterie de secours (300) configurée pour stocker une puissance délivrée par l'unité de conversion d'énergie électrique (200).

MOBILE COMMUNICATION NETWORK AND OF VIDEODIFFUSION WAITER AND PROCEDED' EXPLOITATION

Dans un système de communication comportant un réseau (201) de communication par radiodiffusion et un réseau (202) de communication par téléphonie mobile, des ressources radioélectriques sont affectées à l'utilisateur d'un terminal (204) de téléphonie mobile en tenant compte d'une priorité d'utilisateur de la radiodiffusion de l'utilisateur.

TRANSMITTER, RECEIVER AND THEIR PROCESS IN A COMMUNICATION SYSTEM WITH THE HUMAN BODY

Récepteur dans un système de communication avec le corps humain, comprenant des électrodes réceptrices (1 à n) comprenant une trame de transmission comprenant des trames de commande (300) et des trames de données (400), des premier et deuxième commutateurs connectés aux électrodes réceptrices (1 à n), une unité de commande de commutation (250) des premier et deuxième commutateurs (211, 212) pour connecter les électrodes réceptrices (1 à n) aux premier et deuxième commutateurs en réponse à chaque trame de commande (300), une unité de traitement de signal (214) en sortie des premier et deuxième commutateurs, une unité de détection de préambule (230) pour générer des valeurs de corrélation de préambule pour le premier préambule, et une unité de traitement de valeur de corrélation (240) commandant l'unité de commande de commutation (250) pour sélectionner des paires d'électrodes réceptrices (1 à n) finales sur la base des valeurs de corrélation de préambule.

FRAME OF LID FOR CONTAINER OF TRANSPORT Of ASSEMBLY OF FUEL NUCLEAR AND CONTAINER OF TRANSPORT FOR NUCLEAR FUEL ASSEMBLIES

Un bâti de couvercle pour un conteneur de transport d'assemblage de combustible nucléaire (10) et un conteneur de transport pour des assemblages de combustible nucléaire sont prévus. Le conteneur de transport comprend un conteneur inférieur (100) dans lequel un berceau (130) est installé, un conteneur supérieur (200) relié de manière démontable au conteneur inférieur (100), et un bâti de base (300) relié au berceau (130) avec au moins un assemblage de combustible nucléaire (10) placé dessus, et le bâti de couvercle (400) comprend une pluralité de supports (410) installés à l'écart l'un de l'autre de façon à entourer l'assemblage de combustible nucléaire placé sur le bâti de base, une pluralité de brides (420) séparées l'une de l'autre, reliées aux supports de façon à être perpendiculaires aux supports, articulées de manière rotative sur le bâti de base, et serrant l'assemblage de combustible nucléaire, et une pluralité de compensateurs d'espace reliés aux surfaces intérieures des supports ...

SUPPORT FRAME AND DISPLAY DEVICE INCLUDING THE ABOVEMENTIONED

Schwarzes, pastenförmiges Verbundmaterial, obere Platte einer Plasmaanzeigetafel und Herstellungsverfahren unter Verwendung desselben

Führungsstift-Basis-Vorrichtung

BIPOLAR BATTERY

MULTI-LAYER CERAMICS SUBSTRATE AND MANUFACTORING PROCESS OF THIS ONE

TRANSMITTER, RECEIVER AND METHOD IN A COMMUNICATION SYSTEM WITH THE HUMAN BODY

DISPLAY DEVICE TO SEIZE the CHARACTERS OF THE AFORESAID DEVICE

La présente invention concerne un dispositif d'affichage permettant de saisir les caractères dudit dispositif. Le dispositif d'affichage comprend : une unité d'affichage qui affiche une interface utilisateur de saisie de caractères comprenant une pluralité d'objets caractères, chaque objet caractère comprenant une bordure et un caractère situé dans la bordure, une unité de saisie qui reçoit une commande utilisateur pour la sélection de l'un de la pluralité d'objets caractères, et un dispositif de commande qui, si un premier objet caractère est sélectionné parmi la pluralité d'objets caractères au travers de l'unité de saisie, commande à l'unité d'affichage d'afficher au moins un objet caractère de recommandation associé au premier caractère en chevauchement partiel avec les objets caractères adjacents au premier objet caractère. Ainsi, un utilisateur peut saisir des caractères plus facilement au moyen de l'interface utilisateur de saisie de caractères.

TUBE PLATE OF A STEAM GENERATOR HAVING A CORROSION-RESISTANT LAYER AND MANUFACTURING METHOD THEREOF

La présente invention concerne une plaque tubulaire d'un générateur de vapeur installée pour supporter un tube du générateur de vapeur et un procédé de fabrication de celle-ci , notamment une plaque tubulaire d'un générateur de vapeur ayant une couche anticorrosive et un procédé de fabrication de celle-ci.

PROCESS AND CIRCUIT Of ADJUSTMENT OF CONTRAST IN a DISPLAY DEVICE

EARTHQUAKE RESISTANT LID FOR CONTAINER TRANSPORTATION OF NUCLEAR FUEL ASSEMBLY AND SHIPPING CONTAINER FOR NUCLEAR FUEL ASSEMBLIES

LIQUID LENS HAS FOCAL VARIABLE WITH TENSION OF REDUCED ORDER

PROCESS AND APPARATUS TO TRANSMIT INFORMATION OF SETS OF CONTROL CHANNELS DIVISIONS IN A MOBILE SYSTEM OF TELECOMMUNICATION ALLOWING THE DATA TRANSMISSION IN MODE OF PACKAGES

ORGANIZES HOLLOW LETTERS HAS PROGRESSIVE RESTITUTION AND ITS PROCESSES OF CREATION, TRANSMISSION AND RESTITUTION

AN APPARATUS FOR TISSUE TREATMENT.

PROCESSOR OF CLOTHING.

.

METHODS FOR TREATING CANCER AND NON-NEOPLASTIC CONDITIONS

Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments. 2. A pharmaceutical composition comprising the compound of .5. The method of claim 3 , wherein the cell is in a subject.6. The method of claim 4 , wherein in the cell is in a subject.13. A method for treating cancer in a human in need thereof claim 1 , comprising administering to the human an effective amount of the compound of .14. A method for treating a non-neoplastic condition in a human in need thereof claim 1 , comprising administering to the human an effective amount of the compound of .15. A method for treating a viral infection in a human in need thereof claim 1 , comprising administering to the human an effective amount of the compound of .16. The method of claim 13 , wherein the cancer is a solid tumor cancer.17. (canceled)18. The method of claim 14 , wherein the non-neoplastic condition is rheumatoid arthritis claim 14 , obesity claim 14 , psoriasis claim 14 , atherosclerosis claim 14 , diabetic retinopathy claim 14 , retinopathy of prematurity claim 14 , retrolental fibroplasia claim 14 , neovascular glaucoma claim 14 , age-related macular degeneration claim 14 , exudative macular ...

SURGICAL DRILL GUIDE ADAPTER WITH A HANDLE AND DETACHABLE HEAD

A dental implant surgical guide system is disclosed. A surgical guide is placed onto a patient's mouth. The surgical guide has one or more tubes for accepting detachable drill guide heads. The detachable drill guide heads are placed into a tube of the surgical guide using a handle. The handle has an attach/detach mechanism. A first drill guide head having a first inner diameter is attached to the handle to guide drilling of a first hole. The first drill guide head is removed using the attach/detach mechanism to accept a second drill guide head having a second inner diameter to guide drilling of a second hole. 1. A surgical guide system comprising:a surgical guide adapted to be placed onto a patient's mouth, the surgical guide having one or more tubes;a first drill guide head having a first inner diameter;a second drill guide head having a second inner diameter; anda handle comprising an attach/detach mechanism,wherein the first drill guide head is attached to the handle, removed from the tube, and detached from the handle using the attach/detach mechanism, andwherein the second drill guide head is attached to the handle and inserted into the tube.2. The surgical guide system of claim 1 , wherein the handle has a profile for clearing obstructions and/or reaching into the back of the patient's mouth.3. The surgical guide system of claim 1 , wherein one of first drill guide head and the second drill guide head is attachable to the handle at at least two different angles.4. The surgical guide system of claim 1 , wherein the attach/detach mechanism provides sufficient torsional rigidity to hold the position of the head while drilling.5. The surgical guide system of claim 1 , wherein the attach/detach mechanism is engaged by a selected from a group comprising a push button switch claim 1 , a slide switch claim 1 , a rocker switch claim 1 , a rotary switch claim 1 , an electrical switch claim 1 , and an electromagnetic switch.6. The surgical guide system of claim 1 , ...

INSECT PROOF AND INSECTICIDAL COMPOSITION FOR THE CONSERVATION OF CULTURAL PROPERTY COMPRISING Asarum sieboldii EXTRACT OR A FRACTION THEREOF AS AN ACTIVE INGREDIENT

Disclosed herein is an insect proof or insecticidal composition for the conservation of cultural properties against termites, comprising an extract of Asarum sieboldii as an active ingredient. Based on a methanol extract of Asarum sieboldii or a hexane fraction from the methanol extract, the composition is environmentally friendly and non-toxic to humans and animals. Also, because of its excellent insecticidal activity against termites, the composition can be used to protect wooden structures and cultural properties from termite damage, which is a great threat to the life of wooden structures and cultural properties, without toxicity to humans and animals.

Method and System for Generating a Dental Implant Surgical Drill Guide

A method and system for producing a dental implant surgical guide is disclosed. A patient-specific virtual model is generated using image data specific to a patient and virtual dental implants. The virtual model aligns the image data with the virtual dental implants using modeling software. A virtual mold is generated from the virtual model, and a physical mold is generated from the virtual mold. The physical mold is covered with a thermoplastic sheet via a thermoforming process. Excess thermoplastic material is trimmed off after the thermoforming process to produce a thermoformed piece. Metal tubes corresponding to each the virtual dental implants are placed onto the physical mold denoting the position, trajectory, and depth of the one or more virtual dental implants. A dental implant surgical guide that contains the thermoformed piece with the one or more tubes is produced. 1. A method for producing a dental implant surgical guide , the method comprising:receiving image data specific to a patient;determining position, trajectory and depth of one or more virtual dental implants;generating a virtual model based on the one or more virtual dental implants, wherein the virtual model aligns the image data with the one or more virtual dental implants;generating a virtual mold based on the virtual model;generating a physical mold from the virtual mold;covering the physical mold with a thermoplastic sheet via a thermoforming process;trimming off excess thermoplastic material after the thermoforming process to produce a thermoformed piece;placing one or more tubes corresponding to each one or more virtual dental implants onto the physical mold, wherein the one or more tube denote the position, trajectory, and depth of the one or more virtual dental implants; andproducing a dental implant surgical guide that contains the thermoformed piece with the one or more tubes.2. The method of claim 1 , wherein the image data provides sufficient resolution claim 1 , image detail claim ...

Indoor artificial breeding method of termite

Provided is a method of collecting wild termites and rearing the termites indoors. The method can be used to observe physiological and ecological characteristics of termites that give serious damage to wooden cultural assets and buildings, and thus basic information can be obtained for controlling termites.

Patient-Specific Three-Dimensional Dentition model

A method and system for generating a color-textured three-dimensional dental model is specific to a patient is disclosed. According to one embodiment, a three-dimensional dental model that is deficient of volumetric data for a three-dimensional anatomical landmark is obtained. A two-dimensional anatomical landmark of a two-dimensional intra-oral photograph that corresponds to the three-dimensional anatomical landmark of the three-dimensional dental model is identified. The two-dimensional intra-oral photograph is projected onto the three-dimensional dental model. The three-dimensional anatomical landmark is calculated from the projection of the two-dimensional anatomical landmark of the two-dimensional intra-oral photograph. 1. A computer-implemented method comprising:identifying a three-dimensional anatomical landmark of a three-dimensional dental model, the three-dimensional anatomical landmark being deficient of volumetric data;identifying a two-dimensional anatomical landmark of a two-dimensional intra-oral photograph that corresponds to the three-dimensional anatomical landmark of the three-dimensional dental model;projecting the two-dimensional intra-oral photograph onto the three-dimensional dental model; andcalculating the three-dimensional anatomical landmark from the projection of the two-dimensional anatomical landmark of the two-dimensional intra-oral photograph.2. The computer-implemented method of further comprising generating a patient-specific color-textured three-dimensional dental model comprising the three-dimensional anatomical landmark.3. The computer-implemented method of claim L wherein the two-dimensional intra-oral photograph is projected onto the three-dimensional dental model using a common anatomical landmark that has volumetric data.4. The computer-implemented method of claim 3 , wherein the common anatomical landmark is selected from a group comprising tips of the teeth claim 3 , interproximal points claim 3 , and gingival margins.5. ...

Apparatus For Generating Volumetric Image and Matching Color Textured External Surface

Embodiments of the invention provide systems and methods for generating combined image data representing a volumetric image of a subject and a color textured external surface of the subject. According to one embodiment, two-dimensional image data and volumetric data of a subject is obtained using it two-dimensional imager and a volumetric scanner, respectively. The two-dimensional image data represent color texture of the subject, and the volumetric data represents both an internal and external structure of the subject. An opacity threshold of the volumetric data is set to render an external surface of the subject without generating external surface mesh data. An array ray is extended from a view point of the two-dimensional image data to the external surface of the subject such that the external surface of the subject has an opacity level higher than the opacity threshold. The two-dimensional image data is mapped to the external surface of the subject based on the extended array ray, and combined image data comprising the two-dimensional image data and the volumetric data is generated. 1. A method comprising:obtaining two-dimensional image data of a surface of the subject using a two-dimensional imager;obtaining volumetric data representing both an internal and external structure of the subject using a volumetric scanner;setting an opacity threshold of the volumetric data to render an external surface of the subject without generating external surface mesh data;extending an array ray from a view point of the two-dimensional image data to the external surface of the subject, wherein the external surface of the subject has an opacity level higher than the opacity threshold;mapping the two-dimensional image data to the external surface of the subject based on the extended array ray; andgenerating combined image data comprising the two-dimensional image data and the volumetric data.2. The method of further comprising visualizing the external surface of the volumetric ...

NOVEL DIPHENYLMETHANE DERIVATIVES AS SGLT2 INHIBITORS

The present invention relates to a compound with a diphenylmethane moiety having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes. The present invention also provides a method for preparing the compound, and a method for preventing or treating metabolic disorders, particularly diabetes, by using the compound. 5. The compound of , wherein said ring A is a benzene , indane , indene , dihydrobenzofuran , dihydroisobenzofuran , benzofuran , dihydrobenzothiophene , benzothiophene , tetrahydronaphthalene , dihydronaphthalene , chroman , chromene , isochroman , isochromene , benzodioxole , benzodioxane , benzooxazine , tetrahydroquinoline , tetrahydroquinoxaline , tetrahydroisoquinoline , indazole , indole , indoline , benzoimidazole , benzooxazole , benzothiazole , benzotriazole , quinazoline , quinoxaline , cinnoline , phthalazine , or benzotriazine ring , which is optionally substituted with a substituent as defined in .6. The compound of , wherein said ring B is a quinoline , quinoxaline , 3 ,4-dihydro-2H-benzo[b][1 ,4]dioxepine , 2 ,3-dihydrobenzo[b]thiophene , indazole , indole , 2 ,3-dihydrobenzo[b][1 ,4]dioxine , benzodioxole , indane , tetrahydronaphthalene , 3 ,4-dihydro-2H-thiochromene , dihydrobenzofuran , benzo[d][1 ,3]oxathiole , tetrahydroquinoline , or 3 ,4-dihydro-2H-benzo[b][1 ,4]oxazine ring , which is optionally substituted with a substituent as defined in .7. The compound of claim 1 , which is selected from the group consisting of:(1) (2S,3R,4R,5S,6R)-2-(7-bromo-6-(4-methoxybenzyl)-2,3-dihydro-1H-inden-4-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;(2) (2S,3R,4R,5S,6R)-2-(7-bromo-6-(4-ethoxybenzyl)-2,3-dihydro-1H-inden-4-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;(3) (2S,3R,4R,5S,6R)-2-(7-bromo-6-(4- ...

UPPER LIMB REHABILITATION ROBOT

There is provided an upper limb rehabilitation robot including: a base frame that has a side to which a connecting support is rotatably laterally connected; a connecting shaft unit that is rotatably disposed at a side of the connecting support; a link unit that has a side coupled to the connecting shaft unit and the other side with an upper limb connector mounted to enable a person who needs rehabilitation to connect an upper limb; an active actuator that rotates a connecting shaft unit; and a manual actuator that generates resistant torque against rotation to the connecting shaft unit. 1. An upper limb rehabilitation robot comprising:a base frame that has a side to which a connecting support is rotatably laterally connected;a connecting shaft unit that is rotatably disposed at a side of the connecting support;a link unit that has a side coupled to the connecting shaft unit and the other side with an upper limb connector mounted to enable a person who needs rehabilitation to connect an upper limb;an active actuator that is disposed at a side of the connecting support, connected with the connecting shaft unit, and rotates the connecting shaft unit; anda manual actuator that is connected to the connecting shaft unit and generates resistant torque against rotation of the connecting shaft unit.2. The upper limp rehabilitation robot of claim 1 , wherein the connecting shaft unit includes:a shaft body that has a rod shape and is rotatably longitudinally disposed on the connecting support; androtary connecting members that are coupled to a side of the shaft body, connected with the active actuator, and receive torque from the active actuator.3. The upper limp rehabilitation robot of claim 1 , wherein the link unit includes:a first rod fixed to the connecting shaft unit;a second rod with an end rotatably coupled to the connecting shaft unit;a third rod with a side rotatably coupled to the other side of the first rod by a pin; anda fourth rod with both ends rotatably coupled ...

REFRIGERATOR

A refrigerator includes a cabinet that defines a lower storage space, a front panel door part, a drawer part connected to the front panel door part, a support member located at the drawer part and configured to seat one or more objects stored in the drawer part, at least one draw-out rail that is configured to connect the drawer part to an inner wall surface of the lower storage space, and that is configured to extend and retract in multiple stages to assist insertion and withdrawal of the drawer part based on movement of the front panel door part, and at least one elevation device that is located at each of both side surfaces of the drawer part, that is connected to each of both sides of the support member, and that is configured to elevate the support member relative to the drawer part. 1. A refrigerator comprising:a cabinet in which an upper storage space and a lower storage space are defined;a door part configured to insert into and withdraw from the cabinet to open and close the lower storage space;a drawer part connected to the door part so as to be inserted into and withdrawn from the lower storage space, the drawer defining an accommodation space;a support member which is provided in the drawer part and on which a food or a container is seated;a draw-out rail connecting the drawer part to an inner wall surface of the storage space and extending in a multistage to insert and withdraw the door part and the drawer part; andan elevation device provided on each of both side surfaces of the drawer part and connected to both side ends of the support member to elevate the support member,wherein a drawer flange having a predetermined width is disposed on an upper end of each of both the side surfaces of the drawer part, andwherein the draw-out rail and the elevation device are disposed inside a space defined below the drawer flange.2. The refrigerator according to claim 1 , wherein the draw-out rail is disposed on a lower end of the drawer part to extend in a front ...

Laser patterning apparatus for three-dimensional object

A laser patterning apparatus for a three-dimensional object includes a laser generator, a beam expander configured to adjust a size of a laser beam generated by the laser generator, a dynamic focusing module configured to adjust a z-axis focus position of the laser beam passing through the beam expander, a scan head configured to adjust x- and y-axis focus position of the laser beam passing through the beam expander, a shape recognizer configured to recognize a shape of a three-dimensional object, and a controller configured to extract x-, y-, and z-axis data of the three-dimensional object and to control the scan head and the dynamic focusing module, in order to pattern the three-dimensional object with the laser beam.

PATIENT-SPECIFIC THREE-DIMENSIONAL DENTITION MODEL

A method and system for generating a color-textured three-dimensional dental model is specific to a patient is disclosed. According to one embodiment, a three-dimensional dental model that is deficient of volumetric data for a three-dimensional anatomical landmark is obtained. A two-dimensional anatomical landmark of a two-dimensional intra-oral photograph that corresponds to the three-dimensional anatomical landmark of the three-dimensional dental model is identified. The two-dimensional intra-oral photograph is projected onto the three-dimensional dental model. The three-dimensional anatomical landmark is calculated from the projection of the two-dimensional anatomical landmark of the two-dimensional intra-oral photograph. 1. A computer-implemented method comprising:receiving a three-dimensional dental model including three-dimensional volumetric data specific to a patient;receiving a plurality of two-dimensional intra-oral photographs specific to the patient;identifying a plurality of three-dimensional anatomical landmarks of the three-dimensional volumetric data;identifying a plurality of two-dimensional anatomical landmarks of the plurality of two-dimensional intra-oral photographs that correspond to the plurality of three-dimensional anatomical landmarks;projecting the plurality of two-dimensional intra-oral photographs onto the three-dimensional dental model based on the plurality of two-dimensional anatomical landmarks that correspond to the plurality of three-dimensional anatomical landmarks; andgenerating a patient-specific three-dimensional dental model including the three-dimensional volumetric data and the plurality of two-dimensional intra-oral photographs.2. The computer-implemented method of claim 1 , further comprising:dividing the three-dimensional dental model into a plurality of sections; andprojecting the plurality of two-dimensional intra-oral photographs onto the plurality of sections of the three-dimensional dental model.3. The computer- ...

Semiconductor device having line-type trench to define active region and method of forming the same

A semiconductor device includes a plurality of parallel-trenches that are parallel to each other, a plurality of intersect-trenches that are parallel to each other, a plurality of active regions that are confined by the parallel-trenches and the intersect-trenches, a plurality of lower conductive lines that cross the active regions, a plurality of upper conductive lines that are parallel to each other, that cross the lower conductive lines, and that cross over the active regions, and data storage elements connected to the active regions. Each of the parallel-trenches and the intersect-trenches is a straight line. The parallel-trenches cross the upper conductive lines and form a first acute angle with the upper conductive lines. The intersect-trenches cross the parallel-trenches and form a second acute angle with the parallel-trenches.

DISPLAY DEVICE

A display device includes a substrate; a bank defining a plurality of emission areas on the substrate; a plurality of light emitting elements at the plurality of emission areas; a plurality of spacers on the bank to surround peripheral portions of the plurality of emission areas, and the plurality of spacers are spaced apart from each other, so that film delamination of a light emitting element can be prevented by minimizing transmission of an impact to the light emitting element.

DISPLAY DEVICE

A display device includes a substrate including a display area having a first display area and a second display area, and a non-display area extending from the display area; a plurality of first sub-data lines disposed in the first display area; a plurality of second sub-data lines disposed in the second display area to correspond to the plurality of first sub-data lines; a control line including a line portion extending in a direction different from a direction in which the plurality of first sub-data lines and the plurality of second sub-data lines extend; and a plurality of transistors disposed between the plurality of first sub-data lines and the plurality of second sub-data lines and controlled by the control line to connect or disconnect the plurality of first sub-data lines and the plurality of second sub-data lines, thereby reducing power consumption by supplying a data signal only to a driving area during divisional driving. 1. A display device , comprising:a substrate including a display area having a first display area and a second display area and a non-display area extending from the display area;a plurality of first sub-data lines disposed in the first display area;a plurality of second sub-data lines disposed in the second display area to correspond to the plurality of first sub-data lines;a control line including a line portion extending in a direction different from a direction in which the plurality of first sub-data lines and the plurality of second sub-data lines extend; anda plurality of transistors disposed between the plurality of first sub-data lines and the plurality of second sub-data lines and controlled by the control line to connect or disconnect the plurality of first sub-data lines and the plurality of second sub-data lines.2. The display device of claim 1 , wherein the plurality of first sub-data lines and the plurality of second sub-data lines are spaced apart from each other.3. The display device of claim 1 , wherein the plurality ...

FIRE SUPPRESSION SYSTEM

A drone-based fire suppression system is disclosed. According to one embodiment, the system includes: an unloader configured to detach a detachable part from a drone; a charging station configured to charge fire suppressant to the detachable part of the drone; and a loader configured to attach the detachable part that is charged by the charging station to the drone. 1. A system comprising:an unloader configured to detach a detachable part from a drone;a charging station configured to charge fire suppressant to the detachable part of the drone; anda loader configured to attach the detachable part that is charged by the charging station to the drone.2. The system of further comprises a landing pad claim 1 ,wherein the landing pad comprises an unloading zone and a loading zone,wherein the unloader detaches the detachable part from the drone in the unloading zone, andwherein the loader attaches the detachable part to the drone in the loading zone.3. The system of claim 2 , wherein the landing pad includes one or more landing strips claim 2 , and wherein a landing strip of the one or more landing strips includes a landing zone in which the drone lands claim 2 , the unloading zone claim 2 , the loading zone claim 2 , and a take-off zone in which the drone takes off from the landing pad.4. The system of further comprises a transport mechanism that is configured to sequentially transport the drone in an order of the landing zone claim 3 , through the unloading zone and the loading zone claim 3 , and to the take-off zone.5. The system of claim 1 , wherein the unloader lowers the detachable part after detaching the detachable part from the drone and detaches a battery pack from the detachable part.6. The system of claim 5 , wherein the charging station attaches a charged battery pack to the detachable part.7. The system of claim 6 , wherein the loader raises the detachable part and attaches the detachable part that is charged with the fire suppressant and the charged battery ...

NEGATIVE ELECTRODE ACTIVE MATERIAL, NEGATIVE ELECTRODE INCLUDING THE NEGATIVE ELECTRODE ACTIVE MATERIAL, SECONDARY BATTERY INCLUDING THE NEGATIVE ELECTRODE, AND METHOD OF PREPARING THE NEGATIVE ELECTRODE ACTIVE MATERIAL

A negative electrode active material as well as a method of preparing a negative electrode active material which includes preparing a silicon-based compound including SiO, wherein 0.5 Подробнее

REFRIGERATOR

A refrigerator includes a cabinet defining a storage chamber, a drawer door, a rail assembly that slidably couples the drawer door to the cabinet, a driving device disposed at the door part, and an elevation device disposed at the drawer part to vertically elevate at least a portion of the drawer part. The driving device includes a motor assembly, a pair of screw units, and a pair of levers, each of the pair of levers being coupled to and configured to be rotated by a corresponding one of the pair of screw units to elevate the elevation device. The drawer door includes a door part configured to open and close the storage chamber and a drawer part that is configured to be inserted into and withdrawn out of the storage chamber and defines a storage space. 1. A refrigerator comprising:a cabinet that defines a storage chamber;a drawer door comprising a door part configured to open and close the storage chamber and a drawer part that is configured to be inserted into and withdrawn out of the storage chamber and defines a storage space;a rail assembly that slidably couples the drawer door to the cabinet;a driving device disposed at the door part and configured to provide a driving force; andan elevation device disposed at the drawer part, the elevation device being coupled to the driving device to vertically elevate at least a portion of the drawer part, a motor assembly,', 'a pair of screw units, each of the pair of screw units being disposed on opposite sides of the motor assembly and configured to be actuated by the motor assembly at the same time as each other, and', 'a pair of levers, each of the pair of levers being coupled to and configured to be rotated by a corresponding one of the pair of screw units, the pair of levers being coupled to and configured to elevate the elevation device, and, 'wherein the driving device comprises a housing,', 'a screw disposed in the housing and configured to be rotated by the motor assembly,', 'a screw holder that receives the ...

REFRIGERATOR

A refrigerator includes a cabinet defining a storage chamber, a drawer door configured to be inserted into and withdrawn out of the storage chamber, a driving device provided at the door part, an elevation device provided at the drawer part and having a scissors lift assembly, and a connecting assembly that couples the driving device to the scissors lift assembly to transfer driving force from the driving device to the scissors lift assembly. The elevation device is configured, based on being uncoupled from the connecting assembly, to be separable from the drawer part, and the elevation device includes a restricting unit configured to restrict the scissors lift assembly from unfolding when the elevation device is separated from the drawer part. The drawer door includes a drawer part and a door part that is configured to, based on the drawer door being inserted into the storage chamber, close the storage chamber. 1. A refrigerator comprising:a cabinet that defines a storage chamber; a drawer part that defines a storage space for storing a food object, and', 'a door part that is configured to, based on the drawer door being inserted into the storage chamber, close the storage chamber;, 'a drawer door configured to be inserted into and withdrawn out of the storage chamber, the drawer door comprisinga driving device provided at the door part and configured to provide a driving force;an elevation device provided at the drawer part and comprising a scissors lift assembly, the scissors lift assembly being configured to be driven by the driving device to thereby unfold and raise the food object stored in the storage space; anda connecting assembly that couples the driving device to the scissors lift assembly to transfer the driving force from the driving device to the scissors lift assembly,wherein the elevation device is configured, based on being uncoupled from the connecting assembly, to be separable from the drawer part, andwherein the elevation device comprises a ...

DOOR FOR HOME APPLIANCE, HOME APPLIANCE, AND METHOD FOR MANUFACTURING THE SAME

A door for a home appliance, a home appliance, and a method for manufacturing the same, are disclosed. The door for a home appliance comprises a panel assembly; and a frame assembly defining a predetermined space having an opening connected with an edge of the panel assembly, and making a foaming space for receiving a thermal insulator by means of the predetermined space of the frame assembly and the edge of the panel assembly, wherein a foaming injection hole through which the thermal insulator is injected is provided on at least one of ends of an upper surface, a lower surface, a left side and a right side of the frame assembly. 1. A refrigerator comprising:a cabinet to define a storage chamber therein; anda door that is hingedly coupled to the cabinet, and is configured to open and close the storage chamber,the door includes a panel assembly and a frame assembly connected to the panel assembly, wherein an insulation space is provided based on the panel assembly and the frame assembly, an insulating material is to be provided in the insulation space, the frame assembly to extend in a first direction between an upper portion and a lower portion, and the frame assembly to extend in a second direction between a first side portion and a second side portion, a front panel made of a transparent material, and', 'an insulation panel provided at a rear of the front panel and spaced apart from the front panel,, 'wherein the panel assembly includes a first injection hole to inject insulating material into the insulation space, and', 'a second injection hole that is spaced apart from the first injection hole, and to inject insulating material into the insulation space,, 'wherein the frame assembly includeswherein first and second injection holes are provided on at least one of the upper portion or the lower portion of the frame assembly, anda first portion of the first injection hole is aligned in the first direction with an upper side or a lower side of the panel assembly.2. ...

REFRIGERATOR

A refrigerator includes: a cabinet; a drawer door assembly including a front panel door part and a drawer part that defines an accommodation space; a rail that movably configured to connect the drawer door assembly to the cabinet and enable the drawer door assembly to insert into and withdraw from the cabinet; a driving device located at the front panel door part and configured to provide power; and an elevation device located in the drawer part and configured to be coupled to the driving device and elevate a portion of the drawer part relative to the front panel door part. The driving device includes: a motor assembly configured to provide driving force; a screw assembly configured to perform an elevation operation based on the driving force; and a lever that connects the screw assembly to the elevation device and that is configured to rotate based on the elevation operation.

REFRIGERATOR

A refrigerator includes a cabinet defining a storage chamber, a door configured to open and close the storage chamber, a cooling device configured to cool the storage chamber, an elevation device configured to move a container in the storage chamber upward and downward, a locking device disposed at the elevation device and configured to, based on the elevation device being rotated about a front end of the elevation device in a folded state, lock the elevation device to the folded state and maintain the folded state, and a support plate that is disposed at the elevation device and includes a handle disposed at a rear portion of the support plate.

Energy transfer structure and energy conversion device

An energy transfer structure includes an energy transfer material and a vacant space part provided in the energy transfer material where the vacant space part is provided through a region occupied with the energy transfer material or from a side of the region occupied with the energy transfer material toward an inside with a predetermined depth.

Electronic apparatus, control method thereof and eletronic system

An electronic apparatus is provided. The electronic apparatus includes a communicator; and a processor configured to: receive multimedia data from an external apparatus through the communicator; identify a plurality of objects in a first frame among a plurality of frames included in the multimedia data; obtain content information corresponding to the plurality of objects in the first frame; obtain a first fingerprint based on the first frame; and control the communicator to transmit the content information and the first fingerprint to a server.

REFRIGERATOR

A refrigerator includes a cabinet defining a storage chamber, a drawer door configured to be inserted into and withdrawn out of the storage chamber, a driving device provided at the door part, an elevation device provided at the drawer part and having a scissors lift assembly, and a connecting assembly that couples the driving device to the scissors lift assembly to transfer driving force from the driving device to the scissors lift assembly. The elevation device is configured, based on being uncoupled from the connecting assembly, to be separable from the drawer part, and the elevation device includes a restricting unit configured to restrict the scissors lift assembly from unfolding when the elevation device is separated from the drawer part. The drawer door includes a drawer part and a door part that is configured to, based on the drawer door being inserted into the storage chamber, close the storage chamber. 1. A refrigerator comprising:a cabinet that defines a storage chamber; a drawer part that defines a storage space configured to store a food object, the drawer part being configured to be inserted into and withdrawn out of the storage chamber, and', 'a door part that is configured to, based on the drawer part being inserted into the storage chamber, close at least a portion of the storage chamber;, 'a drawer door configured to be inserted into and withdrawn out of the storage chamber, the drawer door comprisinga driving device disposed at the drawer door; and a lower frame configured to be seated on a bottom surface of the drawer part,', 'an upper frame configured to be elevated relative to the lower frame and to support the food object, and', 'a restricting unit disposed at each of the upper frame and the lower frame and configured to selectively restrict the upper frame and the lower frame from moving relative to each other,, 'an elevation device detachably disposed inside the drawer part and configured to be elevated by a driving force of the driving ...

SYSTEM AND METHOD FOR PROVIDING COMPACT NAVIGATION-BASED SURGICAL GUIDE IN DENTAL IMPLANT SURGERY

A system and method for providing compact navigation-based surgical guide for dental implant surgery is disclosed. According to one embodiment, a surgical guide system comprise includes a surgical guide comprising having a tracking marker. The surgical guide is fabricated to be custom fitted to a patient's mouth or jawbone. The tracking marker is placed at an implant site according to a virtual implant plan. A sensor placed on a drill piece detects electromagnetic signals that are used to determine the position of the tracking marker. A computer in communication with the sensor processes the tracking marker data received from the sensor, determines a relative position of the drill piece with respect to the tracking marker, and provides real-time tracking of the drill piece on the display of the computer. 1. A surgical guide system comprising:a surgical guide comprising a tracking marker, wherein the surgical guide is fabricated to be custom fitted to a patient's mouth or jawbone, and the tracking marker is placed at an implant site according to a virtual implant plan;a drill piece comprising a sensor and a drill bit, wherein the sensor detects electromagnetic signals from the tracking marker and generates a relative position data of the tracking marker;a computer comprising a display and connected with the drill piece,wherein the computer receives the relative position data of the tracking marker from the sensor, determines a relative position of the tracking marker with respect to the drill piece using the relative position data of the tracking marker, correlates the relative position of the tracking marker to a predetermined virtual position of the tracking marker in the virtual implant plan, and provides real-time visual feedback of the drill piece on the display of the computer.2. The surgical guide system of claim 1 , wherein the tracking marker comprises three or more marking objects.3. The surgical guide system of claim 2 , wherein the computer determines the ...

VIRTUAL FLYING CAMERA SYSTEM

A virtual flying camera system is disclosed. According to one embodiment, the virtual flying camera system includes a plurality of cameras disposed along a track and spaced apart from each other, a recording system configured to receive input video streams from the plurality of cameras, and a control system configured to generate an output video stream from the input video streams. The output video stream includes a view of a virtually flying camera following a target at a user-adjustable speed. The control system generates the output video stream by merging a plurality of portions of the input video streams from adjacent cameras of the plurality of cameras. 1. A camera system comprising:a plurality of cameras disposed along a track and spaced apart from each other;a recording system configured to receive input video streams from the plurality of cameras; anda control system configured to generate an output video stream from the input video streams,wherein the output video stream includes a view of a virtually flying camera following a target at a user-adjustable speed, andwherein the control system generates the output video stream by merging a plurality of portions of the input video streams from adjacent cameras of the plurality of cameras.2. The camera system of further comprising a plurality of camera modules claim 1 , wherein a group of the plurality of cameras are mounted to each of the plurality of camera modules.3. The camera system of claim 1 , wherein the plurality of cameras are positioned at a predetermined interval.4. The camera system of claim 3 , wherein the control system determines a speed of the target based on time stamps of the input video stream and the predetermined interval between the plurality of cameras.5. The camera system of claim 1 , wherein the recording system includes a data interface configured to receive the input video streams from the plurality of cameras via a cable and a storage configured to record the input video streams.6. ...

REFRIGERATOR AND ELEVATION DEVICE FOR REFRIGERATOR

An elevation device for a refrigerator drawer includes a lower frame, an upper frame, and a lifting assembly. The lifting assembly includes: a pair of first rods having a first end rotatably coupled to the lower frame and a second end that translates along the upper frame; and a pair of second rods having a first end rotatably coupled to the upper frame and a second end that translates along the lower frame. The second rod is rotatably coupled to and crosses the first rod. The first or second rod is connected to a driving device via the first end of the first or second rod, with the driving device disposed outside the upper frame and the lower frame. The first and second rods are configured to, based on power from the driving device, rotate about their respective first ends to elevate the upper frame relative to the lower frame. 1. A refrigerator comprising:a cabinet that defines an upper storage space and a lower storage space;a front panel door part configured to open and close the lower storage space;a drawer part disposed rearward of the front panel door part and configured to insert into and withdraw from the lower storage space;a draw-out rail guiding the insertion and withdrawal of the drawer part;a driving device disposed at the front panel door part;a door cover that is disposed at a rear surface of the front panel door part and that covers the driving device;an elevation device disposed at the drawer part and configured to elevate an object stored in the drawer part, a lower frame disposed inside of the drawer part,', 'an upper frame disposed above the lower frame and configured to support the object,', 'a lifting assembly comprising a plurality of rods that are rotatably coupled to each other, that cross each other, and that connect the lower frame to the upper frame, and', 'a rotation shaft that protrudes from the lower frame and that is configured to connect to the driving device,, 'wherein the elevation device compriseswherein the driving device is ...

PATIENT-SPECIFIC THREE-DIMENSIONAL DENTITION MODEL

A method and system for generating a color-textured three-dimensional dental model is specific to a patient is disclosed. According to one embodiment, a three-dimensional dental model that is deficient of volumetric data for a three-dimensional anatomical landmark is obtained. A two-dimensional anatomical landmark of a two-dimensional intra-oral photograph that corresponds to the three-dimensional anatomical landmark of the three-dimensional dental model is identified. The two-dimensional intra-oral photograph is projected onto the three-dimensional dental model. The three-dimensional anatomical landmark is calculated from the projection of the two-dimensional anatomical landmark of the two-dimensional intra-oral photograph. 1. A computer-implemented method comprising:receiving a three-dimensional dental model including three-dimensional volumetric data specific to a patient;receiving a plurality of two-dimensional intra-oral photographs specific to the patient;identifying a plurality of three-dimensional anatomical landmarks of the three-dimensional volumetric data;identifying a plurality of two-dimensional anatomical landmarks of the plurality of two-dimensional intra-oral photographs that correspond to the plurality of three-dimensional anatomical landmarks;projecting the plurality of two-dimensional intra-oral photographs onto the three-dimensional dental model based on the plurality of two-dimensional anatomical landmarks that correspond to the plurality of three-dimensional anatomical landmarks; andgenerating a patient-specific three-dimensional dental model including the three-dimensional volumetric data and the plurality of two-dimensional intra-oral photographs.2. The computer-implemented method of claim 1 , further comprising:dividing the three-dimensional dental model into a plurality of sections; andprojecting the plurality of two-dimensional intra-oral photographs onto the plurality of sections of the three-dimensional dental model.3. The computer- ...

ADJUSTABLE ANATOMY DISPLAY TABLE

An adjustable anatomy display table is disclosed. According to one embodiment, the adjustable anatomy table includes a display configured to visualize the anatomy in a real size, a base configured to support the display, and an adjustable mechanism that mechanically couples the display to the base. The adjustable mechanism is configured to adjust a position of the display relative to the base. 1. An imaging system comprising:a display configured to visualize an image of an anatomy in a 1:1 life size of a patient, wherein the display has long sides and short sides;a base configured to support the display; andan adjustable mechanism that mechanically couples the display to the base,wherein the adjustable mechanism is configured to provide a plurality of adjustable positions of the display relative to the base,wherein the plurality of adjustable positions include a horizontal position in which the long sides and short sides of the display are in parallel to a ground at a same height and an upright position in which a first short side and a second short side of the short sides of the display are in parallel to the ground at different heights.2. The imaging system of claim 1 , wherein the plurality of adjustable positions further include an an upright position in which a first short side and a second short side of the short sides of the display are in parallel to the ground at different heights.3. The imaging system of claim 1 , wherein the adjustable mechanism is a tilting mechanism that is configured to tilt the display from the horizontal position to the upright position.4. The imaging system of claim 1 , wherein the adjustable mechanism further includes a rotational mechanism that is configured to rotate the display about a rotational axis.5. The imaging system of claim 1 , wherein the height adjusting mechanism is configured to adjust a height of the display in the horizontal position.6. The imaging system of claim 1 , wherein the anatomy is a human anatomy claim 1 ...

NEGATIVE ELECTRODE ACTIVE MATERIAL, NEGATIVE ELECTRODE INCLUDING NEGATIVE ELECTRODE ACTIVE MATERIAL, AND SECONDARY BATTERY INCLUDING NEGATIVE ELECTRODE

A negative electrode active material including silicon-based active material particles each including a core including SiO, wherein 0≤x≤2, and a coating layer present on the core. Also, a negative electrode active material in which the coating layer is any one of a carbon coating layer or a polymer coating layer, and the coating layer includes a fluorinated material including at least one of an alkali metal or an alkaline earth metal. 1. A negative electrode active material comprising:{'sub': 'x', 'b': '0', 'silicon-based active material particles comprising a core comprising SiO, wherein ≤x≤2, and a coating layer present on the core,'}wherein the coating layer is a carbon coating layer or a polymer coating layer, andthe coating layer comprises a fluorinated material comprising at least one selected from the group consisting of an alkali metal and an alkaline earth metal.2. The negative electrode active material of claim 1 , wherein the fluorinated material comprises at least one selected from the group consisting of LiF claim 1 , NaF and MgF.3. The negative electrode active material of claim 1 , wherein the fluorinated material is present in an amount of 0.1 wt % to 20 wt % claim 1 , based on a total weight of the coating layer.4. The negative electrode active material of claim 1 , wherein at least a part of the fluorinated material is spaced apart from the core.5. The negative electrode active material of claim 1 , wherein the silicon-based active material particles are in the form of single particles claim 1 , and{'sub': '50', 'an average particle diameter (D) of the silicon-based active material particles in the form of single particles is 0.1 μm to 50 μm.'}6. The negative electrode active material of claim 1 , wherein the silicon-based active material particles are in the form of primary particles agglomerated with each other to form secondary particles.7. The negative electrode active material of claim 6 , wherein an average particle diameter (D) of the ...

REFRIGERATOR AND ELEVATION DEVICE FOR REFRIGERATOR

An elevation device for a refrigerator drawer includes a lower frame, an upper frame, and a lifting assembly. The lifting assembly includes: a pair of first rods having a first end rotatably coupled to the lower frame and a second end that translates along the upper frame; and a pair of second rods having a first end rotatably coupled to the upper frame and a second end that translates along the lower frame. The second rod is rotatably coupled to and crosses the first rod. The first or second rod is connected to a driving device via the first end of the first or second rod, with the driving device disposed outside the upper frame and the lower frame. The first and second rods are configured to, based on power from the driving device, rotate about their respective first ends to elevate the upper frame relative to the lower frame. 1. A refrigerator comprising:a cabinet that defines an upper storage space and a lower storage space;a front panel door part configured to open and close the lower storage space;a drawer part disposed rearward of the front panel door part and configured to insert into and withdraw from the lower storage space;a draw-out rail guiding the insertion and withdrawal of the drawer part;a driving device disposed at the front panel door part;an elevation device disposed at the drawer part and configured to elevate an object stored in the drawer part, a lower frame disposed inside of the drawer part,', 'an upper frame disposed above the lower frame and configured to support the object,', 'a lifting assembly comprising a plurality of rods that are rotatably coupled to each other, that cross each other, and that connect the lower frame to the upper frame, and', 'a rotation shaft that protrudes from the lifting assembly and that is configured to connect to the driving device., 'wherein the elevation device comprises2. The refrigerator according to claim 1 , wherein the plurality of rods comprises:a pair of first rods comprising a first rod, the pair of ...

COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. 110-. (canceled)13. (canceled)14. (canceled)17. The method of claim 16 , wherein Ris heterocyclyl selected from azetidinyl claim 16 , tetrahydrofuranyl claim 16 , pyrrolidinyl claim 16 , piperidinyl claim 16 , piperazinyl claim 16 , 1 claim 16 ,4-diazepanyl claim 16 , 1 claim 16 ,2 claim 16 ,5 claim 16 ,6-tetrahydropyridinyl claim 16 , 1 claim 16 ,2 claim 16 ,3 claim 16 ,6-tetrahydropyridinyl claim 16 , hexahydropyrrolo[3 claim 16 ,4-b]pyrrol-(1H)-yl claim 16 , (3aS claim 16 ,6aS)-hexahydropyrrolo[3 claim 16 ,4-b]pyrrol-(1H)-yl claim 16 , (3 aR claim 16 , 6aR)-hexahydropyrrolo[3 claim 16 ,4-b]pyrrol-(1H)-yl claim 16 , hexahydropyrrolo[3 claim 16 ,4-b]pyrrol-(2H)-yl claim 16 , (3aS claim 16 ,6aS)-hexahydropyrrolo[3 claim 16 ,4-b]pyrrol-(2H)-yl claim 16 , hexahydropyrrolo[3 claim 16 ,4-c]pyrrol-(1H)-yl claim 16 , (3aR claim 16 ,6aS)-hexahydropyrrolo[3 claim 16 ,4-c]pyrrol-(1H)-yl claim 16 , octahydro-5H-pyrrolo[3 claim 16 ,2-c]pyridinyl claim 16 , octahydro-6H-pyrrolo[3 claim 16 ,4-b]pyridinyl claim 16 , (4aR claim 16 ,7aR)-octahydro-6H-pyrrolo[3 claim 16 ,4-b]pyridinyl claim 16 , (4aS claim 16 ,7aS)-octahydro-6H-pyrrolo[3 claim 16 ,4-b]pyridinyl claim 16 , hexahydropyrrolo[1 claim 16 ,2-a]pyrazin-(2H)-one claim 16 , hexahydropyrrolo[1 claim 16 ,2-a]pyrazin-(1H)-yl claim 16 , (7R claim 16 ,8aS)-hexahydropyrrolo[1 claim 16 ,2-a]pyrazin-(1H)-yl claim 16 , (8aS)-hexahydropyrrolo[1 claim 16 ,2-a]pyrazin-(1H)-yl claim 16 , (8aR)-hexahydropyrrolo[1 claim 16 ,2-a]pyrazin-(1H)-yl claim 16 , (8aS)-octahydropyrrolo[1 claim 16 ,2-a]pyrazin-(1H)-yl claim 16 , (8aR)-octahydropyrrolo[1 claim 16 ,2-a]pyrazin-(1H)-yl claim 16 , octahydro-2H-pyrido[1 claim 16 ,2-a]pyrazinyl claim 16 , 3-azabicyclo[3.1.0]hexyl claim 16 , (1R claim 16 ,5S)-3-azabicyclo[3.1.0]hexyl claim 16 , 8-azabicyclo[3.2.1]octyl claim 16 , (1R claim 16 ,5S)-8-azabicyclo[3.2.1]octyl claim 16 , 8-azabicyclo[3.2 ...

PANEL, ELECTRONIC DEVICE AND TRANSISTOR

A panel comprises a substrate; a transistor disposed on the substrate and including: a source electrode, a drain electrode, a gate electrode, a gate insulation layer, an active layer, an auxiliary source electrode configured to electrically connect one end of the active layer to the source electrode, and an auxiliary drain electrode configured to electrically connect an other end of the active layer to the drain electrode; and a capacitor disposed on the substrate and including a first plate and a second plate. The first plate of the capacitor is made of a same material as the auxiliary source electrode and the auxiliary drain electrode. 1. A panel , comprising:a substrate;a transistor disposed on the substrate and including:a source electrode,a drain electrode,a gate electrode,a gate insulation layer,an active layer,an auxiliary source electrode configured to electrically connect one end of the active layer to the source electrode, andan auxiliary drain electrode configured to electrically connect another end of the active layer to the drain electrode; anda capacitor disposed on the substrate and including a first plate and a second plate,wherein the first plate of the capacitor includes a same material as the auxiliary source electrode and the auxiliary drain electrode,wherein at least one of the auxiliary source electrode and the auxiliary drain electrode includes a metal or a conductive oxide including one of Indium Tin Oxide (ITO), Indium Zinc Oxide (IZO), ZnO, SnO2, TiO2, Ga-doped ZnO (GZO), and Al-doped ZnO (AZO),wherein the first plate of the capacitor is spaced apart from the auxiliary source electrode electrically connecting the active layer to the source electrode and the auxiliary drain electrode electrically connecting the active layer to the drain electrode, and does not overlap any of the source electrode and the drain electrode in a plain view, andwherein at least one of a part of the auxiliary source electrode and a part of the auxiliary drain ...

COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively. 2. The compound of claim 1 , wherein:{'sub': 1', '2', '1', '2', '1', '2', '1', '2', '1', '1', '2', '2', '1', '2', '2', '1, 'wand ware C—Ror C—R; wherein, one of wand wis C—Rand the other is C—R, provided that, when wis C—R, then wis C—R; or, when wis C—R, then wis C—R;'}{'sub': 1', '1-8', '1-8', '1-8', '1-8', '2', '1-8', '1-8', '1-8', '1-8', '1-8', '1-8', '1-8', '2', '1-8', '1-8', '1-8', '1-8', '1-8', '1-8', '2', '1-8', '1-8', '1-8', '1-8', '1-8', '1-8', '1-8', '2', '1-8', '1-8', '1-8', '1-8', '1-8', '1-8', '2', '1-8', '1-8', '1-8', '1-8', '2', '1-8', '1-8', '2', '1-8', '1-8', '1-8', '1-8', '1-8', '1-8', '2', '1-8', '1-8', '1-8', '1-8', '1-8', '1-8', '2', '1-8', '1-8', '1-8', '1-8', '1-8', '2-8', '1-8', '2-8', '1-8', '2', '2-8', '2-8', '1-8', '2-8', '1-8', '2', '2-8', '1-8', '1-8', '2', '1-8', '1-8', '1-8', '1-8', '1-8', '2', '1-8', '1-8', '1-8', '1-8', '1-8', '2', '1-8', '1-8', '1-8', '1-8', '1-8', '1-8', '1-8', '2', '1-8', '1-8', '1-8', '1-8', '1-8', '2', '1-8', '1-8', '1-8', '1-8', '1-8', '2', '1-8', '1-8', '1-8', '1-8', '2', '1-8', '1-8', '1-8', '1-8', '1-8', '2', '1-8', '1-8', '1-8', '1-8', '1-8', '1-8', '1-8', '1-8', '1-8', '1-8', '1-8', '1-8', '2', '1-8', '1-8', '1-8', '1-8', '1-8', '2', '1-8', '1-8', '1-8', '1-8', '1-8', '1-8', '2', '1-8', '1-8', '1-8', '1-8', '1-8', '2', '1-8', '1-8', '1-8 ...

DOOR FOR HOME APPLIANCE, HOME APPLIANCE, AND METHOD FOR MANUFACTURING THE SAME

A door for a home appliance, a home appliance, and a method for manufacturing the same, are disclosed. The door for a home appliance comprises a panel assembly; and a frame assembly defining a predetermined space having an opening connected with an edge of the panel assembly, and making a foaming space for receiving a thermal insulator by means of the predetermined space of the frame assembly and the edge of the panel assembly, wherein a foaming injection hole through which the thermal insulator is injected is provided on at least one of ends of an upper surface, a lower surface, a left side and a right side of the frame assembly. 120-. (canceled)21. A refrigerator comprising:a cabinet defining a storage chamber therein; anda door connected to the cabinet and configured to open and close the storage chamber, the door comprising:a panel assembly comprising:a front panel;an insulating panel spaced apart from the front panel; anda spacer arranged between the front panel and the insulating panel of the panel assembly,the panel assembly comprising an upper surface, a lower surface, a first side surface, and a second side surface; anda frame assembly that is connected to the front panel of the panel assembly, and that is configured to cover a portion of a rear surface of the insulating panel of the panel assembly, the frame assembly comprising:an upper frame and a lower frame;at least one side frame that is connected to the upper frame and the lower frame, and that has a length that is longer than a length of the upper frame and longer than a length of the lower frame; anda rear frame that is connected to the at least one side frame and that is in contact with the insulating panel of the panel assembly of the door,wherein the panel assembly and the frame assembly together define an insulation space therebetween that extends along the upper surface, the lower surface, the first side surface, and the second side surface of the panel assembly,wherein at least one insulating ...

COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. 115-. (canceled)17. The compound of claim 16 , wherein Ris heterocyclyl selected from azetidinyl claim 16 , tetrahydrofuranyl claim 16 , pyrrolidinyl claim 16 , piperidinyl claim 16 , piperazinyl claim 16 , 1 claim 16 ,4-diazepanyl claim 16 , 1 claim 16 ,2 claim 16 ,5 claim 16 ,6-tetrahydropyridinyl claim 16 , 1 claim 16 ,2 claim 16 ,3 claim 16 ,6-tetrahydropyridinyl claim 16 , hexahydropyrrolo[3 claim 16 ,4-b]pyrrol-(1H)-yl claim 16 , (3aS claim 16 ,6aS)-hexahydropyrrolo[3 claim 16 ,4-b]pyrrol-(1H)-yl claim 16 , (3aR claim 16 ,6aR)-hexahydropyrrolo[3 claim 16 ,4-b]pyrrol-(1H)-yl claim 16 , hexahydropyrrolo[3 claim 16 ,4-b]pyrrol-(2H)-yl claim 16 , (3 aS claim 16 ,6aS)-hexahydropyrrolo[3 claim 16 ,4-b]pyrrol-(2H)-yl claim 16 , hexahydropyrrolo[3 claim 16 ,4-c]pyrrol-(1H)-yl claim 16 , (3aR claim 16 ,6aS)-hexahydropyrrolo[3 claim 16 ,4-c]pyrrol-(1H)-yl claim 16 , octahydro-5H-pyrrolo[3 claim 16 ,2-c]pyridinyl claim 16 , octahydro-6H-pyrrolo[3 claim 16 ,4-b]pyridinyl claim 16 , (4aR claim 16 ,7aR)-octahydro-6H-pyrrolo[3 claim 16 ,4-b]pyridinyl claim 16 , (4aS claim 16 ,7aS)-octahydro-6H-pyrrolo[3 claim 16 ,4-b]pyridinyl claim 16 , hexahydropyrrolo[1 claim 16 ,2-a]pyrazin-(2H)-one claim 16 , hexahydropyrrolo[1 claim 16 ,2-a]pyrazin-(1H)-yl claim 16 , (7R claim 16 ,8aS)-hexahydropyrrolo[1 claim 16 ,2-a]pyrazin-(1H)-yl claim 16 , (8aS)-hexahydropyrrolo[1 claim 16 ,2-a]pyrazin-(1H)-yl claim 16 , (8aR)-hexahydropyrrolo[1 claim 16 ,2-a]pyrazin-(1H)-yl claim 16 , (8aS)-octahydropyrrolo[1 claim 16 ,2-a]pyrazin-(1H)-yl claim 16 , (8aR)-octahydropyrrolo[1 claim 16 ,2-a]pyrazin-(1H)-yl claim 16 , octahydro-2H-pyrido[1 claim 16 ,2-a]pyrazinyl claim 16 , 3-azabicyclo[3.1.0]hexyl claim 16 , (1R claim 16 ,5S)-3-azabicyclo[3.1.0]hexyl claim 16 , 8-azabicyclo[3.2.1]octyl claim 16 , (1R claim 16 ,5S)-8-azabicyclo[3.2.1]octyl claim 16 , 8-azabicyclo[3.2.1]oct-2-enyl claim 16 , ( ...

TETRAHYDROCARBAZOLES AS ACTIVE AGENTS FOR INHIBITING VEGF PRODUCTION BY TRANSLATIONAL CONTROL

The present invention relates to methods, compounds, and compositions for inhibiting angiogenesis. More particularly, the present invention relates to methods, compounds, and compositions for inhibiting VEGF production. 144.-. (canceled)4854-. (canceled) The present application claims priority to and the benefit under 35 U.S.C. §119 of U.S. Provisional Application No. U.S. Provisional Application No. 60/633,738, filed Dec. 6, 2004, which application is herein incorporated by reference in its entirety. The present application claims priority to and the benefit under 35 U.S.C. §119 of U.S. Provisional Application No. 60/629,889, filed Nov. 23, 2004, and U.S. Provisional Application No. 60/639,283, filed Dec. 27, 2004.The present invention relates to methods, compounds, and compositions for inhibiting angiogenesis. More particularly, the present invention relates to methods, compounds, and compositions for inhibiting VEGF production.Aberrant angiogenesis plays a critical role in the pathogenesis of numerous diseases, including malignant, ischemic, inflammatory and immune disorders (1, 2). The best-known of these disorders are cancer, exudative macular degeneration and diabetic retinopathy (DR), the last two of which are leading cause of blindness in the United States (3, 4). During the last decade our understanding of the molecular basis of angiogenesis has grown considerably. Numerous cytokines and growth factors that stimulate angiogenesis, such as VEGF, FGF-2, PDGF, IGF-1, TGF, TNFα, G-CSF have been identified (5-7). Among these growth factors, Vascular Endothelial Growth Factor (VEGF) plays a central role in angiogenesis (2).VEGF, also known as VEGF-A, was initially identified for its ability to induce vascular permeability and to promote vascular endothelial cell proliferation (8-10). VEGF is encoded by a single gene that gives rise to four isoforms by alternative splicing (11). All four isoforms share the same unusually long and GC rich 5′-UTR, as well as a 3′- ...

NEGATIVE ELECTRODE ACTIVE MATERIAL AND SECONDARY BATTERY INCLUDING THE SAME

The present disclosure relates to a negative electrode active material and a secondary battery including the same, and in particular, provides a negative electrode active material particle including a core including a carbon-based active material, and a shell surrounding the core and including a polymer, wherein silicon-based active material particles are embedded in the shell, and at least a part of the silicon-based active material particles are exposed to a surface of the shell. 1. A negative electrode active material particle comprising:a core including a carbon-based active material; anda shell surrounding the core and including a polymer,wherein silicon-based active material particles are embedded in the shell, and at least a part of the silicon-based active material particles are exposed to a surface of the shell.2. The negative electrode active material particle of claim 1 , wherein at least a part of the silicon-based active material particles in the negative electrode active material particle are present as being exposed to outside the surface of the shell.3. The negative electrode active material particle of claim 1 , wherein the silicon-based active material particles are separated from the core.4. The negative electrode active material particle of claim 1 , wherein the polymer is a polymer having a n-bond.5. The negative electrode active material particle of claim 1 , wherein the polymer is one or more types selected from the group consisting of poly(1-pyrenemethyl methacrylate) which is a homopolymer of pyrene claim 1 , poly(1-pyrenemethyl methacrylate-co-triethylene oxide methyl ether methacrylate) which is a copolymer of pyrene claim 1 , a polymer changing the pyrene side chain of the homopolymer or the copolymer of pyrene to anthracene claim 1 , polyparaphenylene claim 1 , polyaniline claim 1 , poly(9 claim 1 ,9-dioctylfluorene-co-fluorenone-co-methylbenzoic ester having a carbonyl group and methylbenzoic ester claim 1 , and polyacetylene having a ...

NOVEL DIPHENYLMETHANE DERIVATIVES AS SGLT2 INHIBITORS

A compound with a diphenylmethane moiety having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney is disclosed. A pharmaceutical composition including the compound as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes is disclosed. A method for preparing the compound, and a method for preventing or treating metabolic disorders, particularly diabetes, by using the compound is provided. 5. The compound of , wherein said ring A is a benzene , indane , indene , tetrahydronaphthalene , dihydronaphthalene ring , which is optionally substituted with a substituent as defined in .6. The compound of , wherein said ring B is a quinoline , quinoxaline , 3 ,4-dihydro-2H-benzo[b][1 ,4]dioxepine , 2 ,3-dihydrobenzo[b]thiophene , indazole , indole , 2 ,3-dihydrobenzo[b][1 ,4]dioxine , benzodioxole , indane , tetrahydronaphthalene , 3 ,4-dihydro-2H-thiochromene , dihydrobenzofuran , benzo[d][1 ,3]oxathiole , tetrahydroquinoline , or 3 ,4-dihydro-2H-benzo[b][1 ,4]oxazine ring , which is optionally substituted with a substituent as defined in .7. The compound of claim 1 , which is selected from the group consisting of:(1) (2S,3R,4R,5S,6R)-2-(7-bromo-6-(4-methoxybenzyl)-2,3-dihydro-1H-inden-4-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;(2) (2S,3R,4R,5S,6R)-2-(7-bromo-6-(4-ethoxybenzyl)-2,3-dihydro-1H-inden-4-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;(3) (2S,3R,4R,5S,6R)-2-(7-bromo-6-(4-ethylbenzyl)-2,3-dihydro-1H-inden-4-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;(4) (2S,3R,4R,5S,6R)-2-(7-chloro-6-(4-methoxybenzyl)-2,3-dihydro-1H-inden-4-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;(5) (2S,3R,4R,5S,6R)-2-(7-fluoro-6-(4-methoxybenzyl)-2,3-dihydro-1H-inden-4-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;(6) (2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-(6-(4-methoxybenzyl)-7-methyl-2,3-dihydro-1H-inden-4-yl)tetrahydro-2H- ...

NEGATIVE ELECTRODE ACTIVE MATERIAL, NEGATIVE ELECTRODE INCLUDING THE SAME, AND SECONDARY BATTERY INCLUDING THE NEGATIVE ELECTRODE

The present invention relates to a negative electrode active material including a carbonaceous matrix having a first particle and a second particle, wherein the first particle includes a silicon core, an oxide layer disposed on the silicon core and including SiO(0 Подробнее

NOVEL CRYSTALLINE FORM OF 5-CHLORO-N-(METHYL)THIOPHENE-2-CARBOXAMIDE METHANESULFONATE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The present invention relates to a novel crystalline form of 5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide methanesulfonate and a pharmaceutical composition containing the same. The novel crystalline form of a compound according to the present invention exhibits excellent stability even in high-temperature and humidity environments, and thus can be favorably used to prevent or treat diseases, such as thrombosis, myocardial infarction, atherosclerosis, inflammation, stroke, angina pectoris, restenosis after angioplasty, and thromboembolism. 1. An anhydrous crystalline 5-chloro-N-({(5S)-2-oxo-3-[4-(5 ,6-dihydro-4H-[1 ,2 ,4]triazin-1-yl)phenyl]-1 ,3-oxazolidin-5-yl}methyl) thiophene-2-carboxamide methanesulfonate (GCC-4401C) , whose X-ray powder diffraction spectrum using Cu-Kα radiation comprises peaks at an angle of diffraction 2θ of 4.302 , 8.621 , 9.606 , 12.103 , 12.879 , 15.648 , 17.353 , 17.949 , 19.26 , 19.577 , 20.252 , 21.792 , 23.108 , 23.356 , 25.76 and 27.463.2. The anhydrous crystalline GCC-4401C of claim 1 , which shows a peak at 178±2° C. in a differential scanning calorimetry (DSC) analysis.3. An anhydrous crystalline 5-chloro-N-({(5S)-2-oxo-3-[4-(5 claim 1 ,6-dihydro-4H-[1 claim 1 ,2 claim 1 ,4]triazin-1-yl)phenyl]-1 claim 1 ,3-oxazolidin-5-yl}methyl) thiophene-2-carboxamide methanesulfonate claim 1 , whose X-ray powder diffraction spectrum using Cu-Kα radiation comprises peaks at an angle of diffraction 2θ of 12.022 claim 1 , 15.721 claim 1 , 15.971 claim 1 , 18.125 claim 1 , 18.928 claim 1 , 19.979 claim 1 , 20.311 claim 1 , 20.726 claim 1 , 21.66 claim 1 , 22.805 claim 1 , 23.18 claim 1 , 23.985 claim 1 , 25.857 claim 1 , 27.25 claim 1 , 27.829 claim 1 , 28 claim 1 , 28.189 and 29.753.4. The anhydrous crystalline 5-chloro-N-({(5S)-2-oxo-3-[4-(5 claim 3 ,6-dihydro-4H-[1 claim 3 ,2 claim 3 ,4]triazin-1-yl)phenyl]-1 claim 3 ,3-oxazolidin-5-yl}methyl) thiophene-2-carboxamide ...

TRANSISTOR ASSEMBLY, AND ORGANIC LIGHT EMITTING DISPLAY PANEL AND ORGANIC LIGHT EMITTING DISPLAY DEVICE INCLUDING THE SAME

Disclosed are a transistor assembly, an organic light emitting display panel including the same, and an organic light emitting display device including the organic light emitting display panel, in which a first electrode of a switching transistor is used as a gate of a driving transistor. 1. A transistor assembly comprising:a substrate;a switching channel provided on the substrate;a gate insulation layer provided on the switching channel to overlap a switching active part configuring the switching channel;a switching gate provided on the gate insulation layer to overlap the switching active part;a first insulation layer covering the switching channel, the gate insulation layer, and the switching gate;a driving channel provided on the first insulation layer;a second insulation layer covering the driving channel and the first insulation layer;a first electrode connected to a first conductor part of the switching channel and provided on the second insulation layer; anda second electrode connected to a second conductor part of the switching channel and provided on the second insulation layer,wherein the first conductor part of the switching channel is disposed to overlap a driving active part of the driving channel.2. The transistor assembly of claim 1 , wherein the first conductor part of the switching channel is used as a gate of a driving transistor including the first insulation layer and the driving channel.3. The transistor assembly of claim 1 , wherein the first conductor part is a source of a switching transistor.4. The transistor assembly of claim 1 , wherein a third conductor part configuring the driving channel is disposed to overlap the first conductor part configuring the switching channel.5. The transistor assembly of claim 4 , wherein the third conductor part of the driving transistor is a source of a driving transistor.6. The transistor assembly of claim 1 , wherein the first electrode is disposed to overlap a third conductor part of the driving channel. ...

TRANSISTOR SUBSTRATE, ORGANIC LIGHT EMITTING DISPLAY PANEL INCLUDING THE SAME, METHOD OF MANUFACTURING THE TRANSISTOR SUBSTRATE, AND ORGANIC LIGHT EMITTING DISPLAY DEVICE INCLUDING THE ORGANIC LIGHT EMITTING DISPLAY PANEL

Disclosed are a transistor substrate, an organic light emitting display panel including the same, a method of manufacturing the transistor substrate, and an organic light emitting display device including the organic light emitting display panel, in which a driving transistor and a switching transistor are provided and each include an oxide semiconductor of which both ends are covered by an insulation layer, and a gate of the driving transistor and a gate of the switching transistor are provided on different layers. 1. A transistor substrate comprising:a substrate;a switching channel on the substrate;a driving channel on the substrate;a gate insulation layer covering the switching channel and the driving channel;a switching gate on the gate insulation layer and overlapping a switching active part which includes an oxide semiconductor and constitutes the switching channel;a first insulation layer covering the switching gate and the gate insulation layer;a driving gate on the first insulation layer and overlapping a driving active part which includes an oxide semiconductor and constitutes the driving channel;a second insulation layer covering the driving gate and the first insulation layer;a first electrode on the second insulation layer and connected to a first conductor part constituting the switching channel and the driving gate; anda second electrode on the second insulation layer and connected to a second conductor part constituting the switching channel.2. The transistor substrate of claim 1 , wherein the driving gate comprises:a first gate electrode on the first insulation layer and overlapping a third conductor part constituting the driving channel, the first gate electrode including a transparent conductive material; anda second gate electrode connected to the first electrode, disposed on the first gate electrode and overlapping the driving active part.3. The transistor substrate of claim 2 , wherein the first gate electrode comprises a first area overlapping ...

PANEL, ELECTRONIC DEVICE AND TRANSISTOR

A panel comprises a substrate; a transistor disposed on the substrate and including: a source electrode, a drain electrode, a gate electrode, a gate insulation layer, an active layer, an auxiliary source electrode configured to electrically connect one end of the active layer to the source electrode, and an auxiliary drain electrode configured to electrically connect an other end of the active layer to the drain electrode; and a capacitor disposed on the substrate and including a first plate and a second plate. The first plate of the capacitor is made of a same material as the auxiliary source electrode and the auxiliary drain electrode. 1. A panel , comprising:a substrate; a source electrode,', 'a drain electrode,', 'a gate electrode,', 'a gate insulation layer,', 'an active layer,', 'an auxiliary source electrode configured to electrically connect one end of the active layer to the source electrode, and', 'an auxiliary drain electrode configured to electrically connect an other end of the active layer to the drain electrode; and, 'a transistor disposed on the substrate and includinga capacitor disposed on the substrate and including a first plate and a second plate,wherein the first plate of the capacitor is made of a same material as the auxiliary source electrode and the auxiliary drain electrode.2. The panel of claim 1 , wherein the gate insulation layer is composed of a dielectric and is between the gate electrode and the active layer to extend between the first plate and the second plate.3. The panel of claim 1 , wherein the active layer is composed of an oxide semiconductor.4. The panel of claim 3 , wherein each of the auxiliary source electrode claim 3 , the auxiliary drain electrode claim 3 , and the first plate is composed of a metal or a conductive oxide semiconductor.5. The panel of claim 4 , wherein:at least one of the auxiliary source electrode, the auxiliary drain electrode, and the first plate is composed of the conductive oxide semiconductor, and ...

NEGATIVE ELECTRODE ACTIVE MATERIAL, NEGATIVE ELECTRODE INCLUDING THE SAME, SECONDARY BATTERY INCLUDING THE NEGATIVE ELECTRODE, AND PREPARATION METHOD OF THE NEGATIVE ELECTRODE ACTIVE MATERIAL

A negative electrode active material including a silicon-carbon-based particle, the silicon-carbon-based particle having a SiCmatrix and boron doped in the SiCmatrix, wherein x of the SiCmatrix is 0.3 or more and less than 0.6. 1. A negative electrode active material , comprising: [{'sub': 'x', 'a SiCmatrix; and'}, {'sub': 'x', 'boron doped in the SiCmatrix,'}], 'a silicon-carbon-based particle, wherein the silicon-carbon-based particle comprises{'sub': 'x', 'wherein x of the SiCmatrix is 0.3 or more and less than 0.6.'}2. The negative electrode active material of claim 1 ,wherein the boron is present in an amount of 0.5 wt % to 1 wt % based on a total weight of the silicon-carbon-based particle.3. The negative electrode active material of claim 1 ,{'sub': '50', 'wherein an average particle diameter (D) of the silicon-carbon-based particles is 1 μm to 10 μm.'}4. The negative electrode active material of claim 1 ,{'sub': 'x', 'wherein the SiCmatrix comprises SiC and Si.'}5. The negative electrode active material of claim 1 , wherein the boron is present inside the SiCmatrix.6. A method for preparing a negative electrode active material claim 1 , the method comprising:forming a matrix fluid by performing a first heat treatment wherein vaporized silicon source, carbon source, and carrier gas are introduced into a first reaction furnace; andreacting the matrix fluid and boron in the gaseous state to form a SiC matrix doped with boron, wherein{'sub': 'x', 'x of the SiCmatrix is 0.3 or more and less than 0.6.'}7. The method of claim 6 ,wherein in the step of forming of the matrix fluid,a ratio of an inflow rate of the vaporized silicon source to an inflow rate of the carbon source is 1:0.3 to 1:0.6.8. The method of claim 6 ,wherein the first heat treatment is performed at a temperature range of 1500° C. to 2500° C.9. The method of claim 6 ,wherein the carrier gas is at least one selected from the group consisting of Ar, He, and Ne.10. The method of claim 6 ,{'sub': 'x', ' ...

COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. 6. The compound of claim 1 , wherein the form is selected from a free acid claim 1 , free base claim 1 , salt claim 1 , isotopologue claim 1 , stereoisomer claim 1 , racemate claim 1 , enantiomer claim 1 , diastereomer or tautomer thereof.7. The compound of claim 6 , wherein the salt form is a chloride claim 6 , hydrobromide claim 6 , hydrochloride claim 6 , dihydrochloride claim 6 , acetate claim 6 , trifluoroacetate or trifluoroacetic acid salt.8. The compound of claim 1 , wherein the compound is selected from the group consisting of:3-(1,3-benzothiazol-2-yl)-7-(piperazin-1-yl)-2H-pyrano[2,3-b]pyridin-2-one3-(4-chloro-1,3-benzothiazol-2-yl)-7-(piperazin-1-yl)-2H-pyrano[2,3-b]pyridin-2-one3-(1,3-benzothiazol-2-yl)-7-(4-methylpiperazin-1-yl)-2H-pyrano[2,3-b]pyridin-2-one3-(1,3-benzothiazol-2-yl)-7-[4-(2-chloroethyl)piperazin-1-yl]-2H-pyrano[2,3-b]pyridin-2-one3-(4-chloro-1,3-benzothiazol-2-yl)-7-(4-methylpiperazin-1-yl)-2H-pyrano[2,3-b]pyridin-2-one3-(4-chloro-1,3-benzothiazol-2-yl)-7-[4-(2-hydroxybenzyl)piperazin-1-yl]-2H-pyrano[2,3-b]pyridin-2-onetert-butyl 4-[3-(1,3-benzothiazol-2-yl)-2-oxo-2H-pyrano[3,2-c]pyridin-7-yl]piperazine-1-carboxylatetert-butyl 4-[3-(4-chloro-1,3-benzothiazol-2-yl)-2-oxo-2H-pyrano[3,2-c]pyridin-7-yl]piperazine-1-carboxylate3-(4-chloro-1,3-benzothiazol-2-yl)-7-(piperazin-1-yl)-2H-pyrano[3,2-c]pyridin-2-one3-(4-chloro-1,3-benzothiazol-2-yl)-7-[4-(2-hydroxyethyl)piperazin-1-yl]-2H-pyrano[2,3-b]pyridin-2-one3-(4-chloro-1,3-benzothiazol-2-yl)-7-(4-methylpiperazin-1-yl)-2H-pyrano[3,2-c]pyridin-2-one3-(4-chloro-1,3-benzothiazol-2-yl)-7-(4-ethylpiperazin-1-yl)-2H-pyrano[2,3-b]pyridin-2-one3-(4-chloro-1,3-benzothiazol-2-yl)-7-(4-propylpiperazin-1-yl)-2H-pyrano[2,3-b]pyridin-2-one3-(1,3-benzothiazol-2-yl)-7-(4-methylpiperazin-1-yl)-2H-pyrano[3,2-c]pyridin-2-one3-(4-methyl-1,3-thiazol-2-yl)-7-(piperazin-1-yl)-2H-pyrano[2,3-b]pyridin-2-one7-( ...

DOOR FOR HOME APPLIANCE, HOME APPLIANCE, AND METHOD FOR MANUFACTURING THE SAME

A door for a home appliance, a home appliance, and a method for manufacturing the same, are disclosed. The door for a home appliance comprises a panel assembly; and a frame assembly defining a predetermined space having an opening connected with an edge of the panel assembly, and making a foaming space for receiving a thermal insulator by means of the predetermined space of the frame assembly and the edge of the panel assembly, wherein a foaming injection hole through which the thermal insulator is injected is provided on at least one of ends of an upper surface, a lower surface, a left side and a right side of the frame assembly. 1. A refrigerator comprising:a cabinet defining a storage chamber therein;a lighting unit provided in the refrigerator; anda door that opens and closes the storage chamber and hingedly coupled to the cabinet,wherein the door includes a panel assembly and a frame assembly connected to the panel assembly,wherein the door defines an insulating space to prevent a heat outside the refrigerator from being transmitted to the storage chamber,the insulating space includes a first insulating space and a second insulating space,wherein the panel assembly includes a front panel made of a transparent material and an insulation panel provided at the rear of the front panel and spaced apart from the front panel,the first insulating space is defined by the front panel and the insulation panel,the second insulating space is defined by the panel assembly and the frame assembly and extended along an outer periphery of the panel assembly,wherein the second insulating space is provided outside the first insulating space and filled with an insulating material,wherein an inlet for injecting insulating material is provided on at least one of the upper portion or lower portion of the frame assembly,at least a portion of the inlet is arranged to overlap an upper side or a lower side of the panel assembly,wherein an interior of the storage chamber is visible through ...

Smart raw cotton total management system

Provided is a smart raw cotton total management system and more particularly, a smart raw cotton total management system which promotes efficiency of raw cotton management by providing a variety of evaluation information on the raw cotton purchased by the member to the member side and totally manages a raw cotton member and a raw cotton supplier by providing purchase prior information to the member when requesting the raw cotton purchase of the member to perform reasonable raw cotton purchase and transaction.

FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS

The disclosure provides novel chemical compounds represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof. The compounds can be used as an inhibitor of Trk and are useful in the treatment of pain, cancer, inflammation, neurodegenerative disease and certain infectious diseases. 2. The compound of claim 1 , wherein Ra phenyl ring substituted with one or more substituent groups are independently selected from the group consisting of fluorine claim 1 , methoxy and ethoxy claim 1 , wherein Rand Rare H claim 1 , wherein Ris selected from the group consisting of H claim 1 , methyl claim 1 , ethyl claim 1 , iso-propyl claim 1 , cyclopropyl claim 1 , t-butyl claim 1 , methoxyethyl and hydroxyethyl.3. The compound of claim 1 , wherein Ris a pyridine ring substituted with at least one selected from the group consisting of fluorine and methoxy claim 1 , wherein Rand Rare H claim 1 , wherein Ris selected from the group consisting of H claim 1 , methyl claim 1 , ethyl claim 1 , iso-propyl claim 1 , cyclopropyl claim 1 , t-butyl claim 1 , methoxyethyl and hydroxyethyl.4. The compound of claim 1 , wherein Ris a pyrid-2-on-3-yl ring optionally substituted with one or more substituent groups independently selected from the group consisting of halogen and C1-C4 alkyl.5. The compound of claim 1 , wherein when —NRRdoes not form a ring structure claim 1 , Ris selected from the group consisting of hydrogen claim 1 , linear C1-C6 alkyl and branched C1-C6 alkyl claim 1 , and Ris selected from the group consisting of linear C1-C6 fluoroalkyl claim 1 , branched C1-C6 fluoroalkyl claim 1 , linear C1-C6 difluoroalkyl claim 1 , branched C1-C6 difluoroalkyl claim 1 , linear C1-C6 trifluoroalkyl claim 1 , branched C1-C6 trifluoroalkyl claim 1 , linear C1-C6 hyroxyalkyl claim 1 , branched C1-C6 hyroxyalkyl claim 1 , linear C2-C6 difluoroalkyl claim 1 , and branched C2-C6 difluoroalkyl.6. The compound of claim 1 , wherein —NRRforming a 4- ...

Method and apparatus for displaying virtual reality image

A user wears a virtual reality mask (VR mask) ( 100 ) and then watches a virtual reality image. The VR mask ( 100 ) blocks light incident from the outside. When the user wears the VR mask ( 100 ), the user cannot discover an obstacle ( 500 ) positioned outside the VR mask ( 100 ). The user may collide with the obstacle ( 500 ) and may be injured by the obstacle ( 500 ). Accordingly, in order to prevent injury to the user who uses the VR mask ( 100 ), it is necessary to make the user recognize the obstacle ( 500 ) positioned outside the VR mask ( 100 ). In order to recognize an obstacle, a virtual reality image and the obstacle may be displayed together, or the amount of light incident from the outside may be adjusted.

ORGANIC LIGHT EMITTING DISPLAY DEVICE AND METHOD FOR MANUFACTURING THE SAME

An organic light emitting display device includes a transparent base member, a touch sensor which includes a touch electrode disposed above the transparent base member and a touch protection layer which covers the touch electrode, a black matrix which is disposed below or above the touch sensor and defines a plurality of opening areas, a plurality of color filters which is disposed on the same plane as the black matrix and corresponds to the plurality of opening areas, a first buffer layer disposed above the upper one of the touch sensor and the plurality of color filters, a thin film transistor disposed above the first buffer layer, and an organic light emitting element which is disposed above the thin film transistor and corresponds to the plurality of opening areas. 1. An organic light emitting display device , comprising:a transparent base member;a touch sensor which includes a touch electrode disposed above the transparent base member and a touch protection layer which covers the touch electrode;a black matrix which is disposed below or above the touch sensor and defines a plurality of opening areas;a plurality of color filters which is disposed on the same plane as the black matrix and corresponds to the plurality of opening areas;a first buffer layer disposed above the upper one of the touch sensor and the plurality of color filters;a thin film transistor disposed above the first buffer layer; andan organic light emitting element which is disposed above the thin film transistor and corresponds to the plurality of opening areas.2. The organic light emitting display device according to claim 1 , wherein the first buffer layer is a single layer or multi layer selected from a group consisting of silicon nitride SiNx claim 1 , silicon oxide SiOx claim 1 , and aluminum oxide AlOx.3. The organic light emitting display device according to claim 1 , wherein the black matrix and the plurality of color filters are disposed below the touch sensor claim 1 , the first ...

MULTIVISION DISPLAY APPARATUS

A multivision display apparatus which enables participants who conduct a video conference to conduct the video conference in a manner in which the participants keep eye contact with each other. The multivision display apparatus includes a plurality of display apparatuses which output images, a bezel provided on an edge of each of the plurality of display apparatuses, a light receiving device which is provided on the bezel positioned at the center of a screen formed with the plurality of display apparatuses to have a vertical length, and receives an image, and an image receiving device which is provided on an upper end of the bezel to be connected to the light receiving device, receives the image received by the light receiving device, generates image data, and transmits the image data to the display apparatuses. 1. A multivision display apparatus comprising:a plurality of display apparatuses which output images;a bezel provided on an edge of each of the plurality of display apparatuses;a light receiving device which is provided on the bezel positioned at a center of a screen formed with the plurality of display apparatuses to have a vertical length, and receives an image; andan image receiving device which is provided on an upper end of the bezel to be connected to the light receiving device, receives the image received by the light receiving device, generates image data, and transmits the image data to the display apparatuses.2. The multivision display apparatus of claim 1 , wherein the light receiving device includes:a light receiver which receives an image from an external source;a body tube which connects the light receiver and the image receiving device; anda reflector which is provided inside the body tube, reflects the image received by the light receiver to the image receiving device.3. The multivision display apparatus of claim 2 , wherein the light receiver is provided with a lens to receive the image from the external source.4. The multivision display ...

THIN FILM TRANSISTOR SUBSTRATE AND DISPLAY DEVICE INCLUDING THE SAME

Disclosed is a thin film transistor substrate which facilitates to realize a bottom gate structure where a gate electrode is disposed below an active layer, and to increase an area for a storage capacitor, and a display device including the same, wherein the thin film transistor substrate may include a light shielding layer, a buffer layer for covering the light shielding layer, and a driving transistor prepared on the buffer layer while being overlapped with the light shielding layer, and provided to supply a driving current to an organic light emitting device. 1. A thin film transistor assembly , comprising:a light shielding layer;a buffer layer covering the light shielding layer; anda driving transistor positioned on the buffer layer while being overlapped with the light shielding layer, and connected to supply a driving current to an organic light emitting device, a driving transistor active layer having a driving transistor source layer, a driving transistor drain layer, and a driving transistor channel layer, wherein the driving transistor active layer is overlapped with the light shielding layer;', 'a driving transistor gate insulating film that overlays the driving transistor channel layer; and', 'a driving transistor upper electrode positioned on the driving transistor gate insulating film,', 'wherein the driving transistor gate electrode is the light shielding layer that receives a first voltage signal, and the driving transistor upper electrode receives a second voltage which is different from the first voltage., 'wherein the driving transistor includes2. The thin film transistor assembly according to claim 1 , wherein the driving transistor upper electrode is electrically connected with the driving transistor source layer.3. The thin film transistor assembly according to claim 1 , wherein a thickness of the buffer layer is larger than a thickness of the driving transistor gate insulating film.4. The thin film transistor assembly according to claim 1 , ...

NEGATIVE ELECTRODE ACTIVE MATERIAL, NEGATIVE ELECTRODE COMPRISING THE NEGATIVE ELECTRODE ACTIVE MATERIAL, AND SECONDARY BATTERY COMPRISING THE NEGATIVE ELECTRODE

A negative electrode active material which includes a secondary particle including first primary particles, wherein the first primary particle includes a core including SiO, wherein 0≤x<2, an intermediate layer which covers at least a portion of a surface of the core and includes silicon nitride, silicon oxynitride, or a mixture thereof, and a carbon coating layer which covers at least a portion of the intermediate layer and includes nitrogen-doped carbon, and a negative electrode and a lithium secondary battery which include the same. 1. A negative electrode active material , comprising:a secondary particle, comprising first primary particles, [{'sub': 'x', 'a core comprising SiO, wherein 0≤x<2;'}, 'an intermediate layer which covers at least a portion of a surface of the core and comprises silicon nitride, silicon oxynitride, or a mixture thereof; and', 'a carbon coating layer which covers at least a portion of the intermediate layer and comprises nitrogen-doped carbon., 'wherein the first primary particles comprise'}2. The negative electrode active material of claim 1 , wherein at least one of the core claim 1 , the intermediate layer claim 1 , and the carbon coating layer of the primary particle comprises a metal compound.3. The negative electrode active material of claim 1 , wherein claim 1 , in addition to the first primary particles claim 1 , the secondary particle further comprises [{'sub': 'x', 'a core comprising SiO, wherein 0≤x<2;'}, 'an intermediate layer which covers at least a portion of a surface of the core and comprises silicon nitride, silicon oxynitride, or a mixture thereof; and', 'a carbon coating layer which covers at least a portion of the intermediate layer and comprises nitrogen-doped carbon,', 'wherein at least one of the core, the intermediate layer, and the carbon coating layer of the metal compound-doped primary particles comprises a metal compound., 'metal compound-doped primary particles which comprise'}4. The negative electrode active ...

METHOD FOR DUAL INHIBITION OF SGLT1 AND SGLT2 USING DIPHENYLMETHANE DERIVATIVES

The present invention relates to a method for dual inhibition of sodium-dependent glucose cotransporter 1 (SGLT1) and sodium-dependent glucose cotransporter 2 (SGLT2) present in the intestine and kidney by using the compound of formula I or a pharmaceutically acceptable salt or a prodrug thereof: 5. The method of , wherein said ring A is a benzene , indane , indene , dihydrobenzofuran , dihydroisobenzofuran , benzofuran , dihydrobenzothiophene , benzothiophene , tetrahydronaphthalene , dihydronaphthalene , chroman , chromene , isochroman , isochromene , benzodioxole , benzodioxane , benzooxazine , tetrahydroquinoline , tetrahydroquinoxaline , tetrahydroisoquinoline , indazole , indole , indoline , benzoimidazole , benzooxazole , benzothiazole , benzotriazole , quinazoline , quinoxaline , cinnoline , phthalazine , or benzotriazine ring , which is optionally substituted with a substituent as defined in .6. The method of , wherein said ring B is a quinoline , quinoxaline , 3 ,4-dihydro-2H-benzo[b][1 ,4]dioxepine , 2 ,3-dihydrobenzo[b]thiophene , indazole , indole , 2 ,3-dihydrobenzo[b][1 ,4]dioxine , benzodioxole , indane , tetrahydronaphthalene , 3 ,4-dihydro-2H-thiochromene , dihydrobenzofuran , benzo[d][1 ,3]oxathiole , tetrahydroquinoline , or 3 ,4-dihydro-2H-benzo[b][1 ,4]oxazine ring , which is optionally substituted with a substituent as defined in .7. The method of claim 1 , wherein the compound of formula I is selected from the group consisting of:(1) (2S,3R,4R,5S,6R)-2-(7-bromo-6-(4-methoxybenzyl)-2,3-dihydro-1H-inden-4-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;(2) (2S,3R,4R,5S,6R)-2-(7-bromo-6-(4-ethoxybenzyl)-2,3-dihydro-1H-inden-4-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;(3) (2S,3R,4R,5S,6R)-2-(7-bromo-6-(4-ethylbenzyl)-2,3-dihydro-1H-inden-4-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;(4) (2S,3R,4R,5S,6R)-2-(7-chloro-6-(4-methoxybenzyl)-2,3-dihydro-1H-inden-4-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;(5) (2S,3R, ...

REFRIGERATOR AND CONTROL METHOD THEREOF

A refrigerator includes a cabinet forming a storage space, a main door that opens and closes the storage space while defining an opening part that is in communication with the storage space, a sub-door mounted to the main door and configured to open and close the opening part, the sub-door including a panel assembly for allowing selective viewing of an inside of the opening part, the injection port is provided at a lower side of the sub-door to direct an insulating foaming solution to a space in the sub-door, a detection device for detecting an operation of a user, a lighting unit inside the refrigerator that turns on based on user operation to allow selective viewing of the inner side of the opening part, and a display unit inside the refrigerator at a position corresponding to the panel. 1. A refrigerator comprising:a cabinet to define a storage chamber therein;a lighting device configured to illuminate the storage chamber; anda door connected to the cabinet and configured to open and close the storage chamber, a door frame having an opening;', 'a panel assembly configured to cover the opening of the door frame;', 'a display provided at rear of the panel assembly;', 'a sensor provided in the door frame, and configured to detect an input applied to the panel assembly; and', 'a processor configured to control the lighting device and the display according to whether the sensor detects the input, and, 'wherein the door includes a space is formed between a lateral side of the panel assembly and the door frame, and', 'an injection port is provided at a position on a lower side of the door frame and directs a foaming solution to the space to form an insulation material., 'wherein2. The refrigerator of claim 1 , wherein the panel assembly includes:a front panel;an insulating panel provided rear of the front panel; anda spacer provided between the front panel and the insulating panel,wherein the front panel and the insulating panel have a viewing area.3. The refrigerator ...

Memory device, memory system, and method of operating memory device

A method of operating a memory device includes: checking for errors in data read from a first address of a memory cell array of the memory device; counting the number of errors that occurred in the data read from the first address; receiving a first command for data read from the first address; determining whether the number of errors that occurred in the data read from the first address is greater than or equal to a first value; and mapping the first address to a second address, if the number of errors that occurred in the data read from the first address is greater than or equal to the first value.

Implant assessment using ultrasound and optical imaging

A system may include an ultrasound probe and a controller unit configured to obtain a baseline ultrasound image of a patient's breast area using the ultrasound probe and to obtain a follow-up ultrasound image of the patient's breast area using the ultrasound probe. The controller unit may further be configured to use one or more machine learning models to compare the baseline ultrasound image with the follow-up ultrasound image; detect a change in a morphology or integrity of the patient's breast area based on the comparison of the baseline ultrasound image with the follow-up ultrasound image; and generate a recommendation for a medical intervention based on the detected change.

REFRIGERATOR AND CONTROL METHOD THEREOF

A refrigerator includes a cabinet forming a storage space, a main door that opens and closes the storage space while defining an opening part that is in communication with the storage space, a sub-door mounted to the main door and configured to open and close the opening part, the sub-door including a panel assembly for allowing selective viewing of an inside of the opening part, a detection device for detecting an operation of a user, a lighting unit inside the refrigerator that turns on based on user operation to allow selective viewing of the inner side of the opening part, and a display unit inside the refrigerator at a position corresponding to the panel assembly that becomes visible and displays an operation state of the refrigerator when the lighting unit turns on. 1. A refrigerator comprising:a cabinet defining a storage space;a main door rotatably mounted to the cabinet and configured to open and close the storage space, the main door defining an opening part that is in communication with the storage space;a sub-door rotatably mounted to the main door and configured to open and close the opening part, the sub-door including a panel assembly that is configured to allow selective viewing of an inner side of the opening part through the panel assembly;a detection device provided to the sub-door and configured to detect an operation of a user;a lighting unit provided inside the refrigerator and configured to, based on the sub-door being closed and based on the detection of the user operation by the detection device, turn on to allow viewing of the inner side of the opening part by causing the panel assembly to appear transparent; anda display unit provided inside the refrigerator at a position corresponding to the panel assembly, the display unit being configured to become visible and display an operation state of the refrigerator based on the lighting unit turning on.2. The refrigerator according to claim 1 , wherein the display unit is detachably provided in ...

Refrigerator and controlling method thereof

Provided is a refrigerator including: a storage compartment in which a plurality of accommodation spaces are disposed; a detection unit that detects a storage container accommodated in the plurality of accommodation spaces; a display unit that displays accommodation information regarding the plurality of accommodation spaces; and a controller that controls the display unit so as to display the accommodation spaces in which a new storage container may be accommodated, based on a result of detection of the detection unit.

REFRIGERATOR

A refrigerator includes: a cabinet defining a first storage space, a door including a drawer part that defines a second storage space inside the first storage space and a door part that is mounted on a front surface of the drawer part to open and close the second storage space, a door gasket sealing a gap between the cabinet and the door, a draw-out motor configured to provide a driving force for a drawing out operation of the door, and a controller configured to control the draw-out motor. The controller is configured to count a number of rotations of the draw-out motor for a set period of time based on the draw-out motor being started for opening of the door according to received input, and stop and re-operate, based on a draw-out distance of the door being shorter than a set distance, the draw-out motor. 1. A refrigerator comprising:a cabinet defining a first storage space;a door including (i) a drawer part that defines a second storage space inside the first storage space and (ii) a door part that is mounted on a front surface of the drawer part to open and close the second storage space;a door gasket made of an elastically deformable material and provided along a periphery of the door part to seal, based on the door being closed, a gap between the cabinet and the door;a draw-out motor configured to provide a driving force for a drawing out operation of the door;a detector configured to detect an open/close state of the door;a manipulation part configured to receive user input to control an operation of the draw-out motor; anda controller configured to control the draw-out motor, count a number of rotations of the draw-out motor for a set period of time based on the draw-out motor being started for opening of the door according to the received input of the manipulation part, and', 'stop and re-operate, based on a draw-out distance of the door being shorter than a set distance, the draw-out motor., 'wherein the controller is configured to2. The refrigerator of ...

Method and device for searching new material

A method for searching a new material includes: performing a learning on a material model, which is modeled based on a known material; determining a candidate material by inputting a targeted physical property to a result of the learning; and determining the new material from the candidate material.

NEGATIVE ELECTRODE ACTIVE MATERIAL AND LITHIUM SECONDARY BATTERY INCLUDING THE SAME

The present invention relates to a silicon-carbon-based composite negative electrode active material, and a negative electrode for a secondary battery and a lithium secondary battery including the same, and particularly to a silicon-carbon-based composite negative electrode active material, in which physical stability is improved by including a carbon-based core capable of intercalating and deintercalating lithium ions and at least one silicon particle included in the carbon-based core and disposed in the form of being distributed in an outer portion of the carbon-based core, and a negative electrode for a secondary battery and a lithium secondary battery in which life characteristics are improved by including the same. 1. A silicon-carbon-based composite negative electrode active material comprising:a carbon-based core capable of intercalating and deintercalating lithium ions; andat least one silicon particle included in the carbon-based core and disposed in a form of being distributed in an outer portion of the carbon-based core.2. The silicon-carbon-based composite negative electrode active material of claim 1 , wherein the carbon-based core comprises a single material selected from the group consisting of natural graphite claim 1 , artificial graphite claim 1 , graphite claim 1 , graphitizable carbon claim 1 , non-graphitizable carbon claim 1 , carbon black claim 1 , and graphite oxide claim 1 , or a mixture of two or more thereof.3. The silicon-carbon-based composite negative electrode active material of claim 1 , wherein an average particle diameter of the carbon-based core is in a range of 5 μm to 30 μm.4. The silicon-carbon-based composite negative electrode active material of claim 1 , wherein the carbon-based core has a concentration gradient in which porosity is gradually increased from a center of the core to the outer portion of the core.5. The silicon-carbon-based composite negative electrode active material of claim 4 , wherein the outer portion of ...

NEGATIVE ELECTRODE ACTIVE MATERIAL AND SECONDARY BATTERY INCLUDING THE SAME

The present invention relates to a negative electrode active material and a secondary battery including the same, and specifically, provides a negative electrode active material particle including a core, which includes a carbon-based active material and an oxygen functional group, and a shell, which surrounds the core and includes a silicon-based active material. 1. A negative electrode active material particle comprising a core , which comprises a carbon-based active material and an oxygen functional group , and a shell which surrounds the core and comprises a silicon-based active material.2. The negative electrode active material particle of claim 1 , wherein the oxygen functional group comprises one or more of a hydrophilic group and a hydrophobic group.3. The negative electrode active material particle of claim 2 , wherein the hydrophilic group comprises one or more of a hydroxyl group and a carboxyl group claim 2 , and the hydrophobic group comprises one or more of an ether group and a carbonyl group.4. The negative electrode active material particle of claim 1 , wherein the oxygen functional group is covalently bound to an outermost carbon atom of the carbon-based active material.5. The negative electrode active material particle of claim 1 , wherein the oxygen functional group is bound to about 2.0 to 4.0% of all sites of an outermost carbon atom of the carbon-based active material at which the oxygen functional group is covalently bondable.6. The negative electrode active material particles of claim 1 , further comprising a coating layer which surrounds the shell and comprises one or more of a carbon-based material and a polymer.7. The negative electrode active material particle of claim 6 , wherein the carbon-based material comprise amorphous carbon claim 6 , and the polymer comprises a conductive polymer.8. The negative electrode active material particle of claim 6 , wherein the coating layer is 1 to 50 wt % of an overall weight of the negative electrode ...

NEGATIVE ELECTRODE ACTIVE MATERIAL FOR LITHIUM SECONDARY BATTERY, METHOD OF PREPARING THE SAME, AND LITHIUM SECONDARY BATTERY INCLUDING THE SAME

The present invention relates to a negative electrode active material for a lithium secondary battery, a method of preparing the same, and a lithium secondary battery including the negative electrode active material, wherein since the negative electrode active material includes a surface-treated silicon nanoparticle and the surface-treated silicon nanoparticle includes a silicon nanoparticle and a surface treatment layer which is disposed on a surface of the silicon nanoparticle and includes crystalline SiO, the negative electrode active material may exhibit significantly improved initial efficiency characteristics as well as excellent lifetime and capacity characteristics when used in a battery. 1. A negative electrode active material for a lithium secondary battery , comprising:a surface-treated silicon nanoparticle,{'sub': '2', 'wherein the surface-treated silicon nanoparticle comprises a silicon nanoparticle and a surface treatment layer which is disposed on a surface of the silicon nanoparticle and includes crystalline SiO.'}2. The negative electrode active material for a lithium secondary battery of claim 1 ,{'sub': '2', 'wherein the crystalline SiOis included in an amount of 2 wt % to 15 wt % based on a total weight of the surface-treated silicon nanoparticle.'}3. The negative electrode active material for a lithium secondary battery of claim 1 ,{'sub': '50', 'wherein the silicon nanoparticle has an average particle diameter (D) of 150 nm or less.'}4. The negative electrode active material for a lithium secondary battery of claim 1 ,wherein the surface treatment layer has a thickness of 1 nm to 20 nm.5. The negative electrode active material for a lithium secondary battery of claim 1 , further comprising a carbon-based negative electrode active material.6. The negative electrode active material for a lithium secondary battery of claim 5 ,wherein the carbon-based negative electrode active material is included in an amount of 10 wt % to 90 wt % based on a total ...

NEGATIVE ELECTRODE ACTIVE MATERIAL, METHOD OF PREPARING THE SAME, AND LITHIUM SECONDARY BATTERY INCLUDING THE SAME

The present invention relates to a negative electrode active material, a method of preparing the same, and a lithium secondary battery including the same. In particular, the present invention relates to a composite negative electrode active material that includes: a core capable of intercalating and deintercalating lithium ions; and a plurality of coating layers comprising two or more Si layers having different densities formed on a surface of the core, and thus has enhanced stability by minimizing the formation of cracks occurring by the repetition of charging and discharging, a method of preparing the same, and a lithium secondary battery including the same and thus exhibiting enhanced lifespan characteristics. 1. A composite negative electrode active material comprising:a core capable of intercalating and deintercalating lithium ions; anda plurality of coating layers comprising two or more silicon (Si) layers having different densities formed on a surface of the core.2. The composite negative electrode active material of claim 1 , wherein the core comprises a carbon-based core or a non-carbon-based core.3. The composite negative electrode active material of claim 2 , wherein the non-carbon-based core comprises Si or a non-crystalline or crystalline Si oxide represented by SiOwhere 0 Подробнее

COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY

Provided herein are compounds of Formula (I): 4. The compound of claim 3 , wherein{'sub': '1', 'Ris heterocyclyl;'}{'sub': 3', '4, 'wherein, heterocyclyl is optionally substituted with one, two or three Rsubstituents and optionally, with one additional Rsubstituent; or,'}{'sub': '3', 'wherein, heterocyclyl is optionally substituted with one, two, three or four Rsubstituents; and'}{'sub': '2', 'Ris aryl or heteroaryl;'}{'sub': 6', '7, 'wherein, aryl or heteroaryl is optionally substituted with one, two or three Rsubstituents and optionally, with one additional Rsubstituent.'}5. The compound of claim 1 , wherein the form is selected from a free acid claim 1 , free base claim 1 , salt claim 1 , enantiomer claim 1 , diastereomer or tautomer thereof.6. The compound of claim 5 , wherein the salt form is a chloride claim 5 , hydrobromide claim 5 , hydrochloride claim 5 , dihydrochloride claim 5 , acetate claim 5 , trifluoroacetate or trifluoroacetic acid salt.7. The compound of claim 1 , wherein the compound is selected from the group consisting of:2-(3,4-dimethoxyphenyl)-7-(1,2,3,6-tetrahydropyridin-4-yl)-4H-pyrazino[1,2-a]pyrimidin-4-one;2-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-7-(1,2,3,6-tetrahydropyridin-4-yl)-4H-pyrazino[1,2-a]pyrimidin-4-one;2-(2-methyl-1,3-benzoxazol-6-yl)-7-(1,2,3,6-tetrahydropyridin-4-yl)-4H-pyrazino[1,2-a]pyrimidin-4-one; hydrochloride (1:1)2-(2-methyl-1,3-benzoxazol-6-yl)-7-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-4H-pyrazino[1,2-a]pyrimidin-4-one;7-(1-ethyl-1,2,3,6-tetrahydropyridin-4-yl)-2-(2-methyl-1,3-benzoxazol-6-yl)-4H-pyrazino[1,2-a]pyrimidin-4-one;2-(1,3-dimethylpyrrolo[1,2-a]pyrazin-7-yl)-7-[1-(propan-2-yl)-1,2,3,6-tetrahydropyridin-4-yl]-4H-pyrazino[1,2-a]pyrimidin-4-one;2-(4,6-dimethylpyrazolo[1,5-a]pyrazin-2-yl)-7-(piperidin-4-yl)-4H-pyrazino[1,2-a]pyrimidin-4-one;2-(4, 6-dimethylpyrazolo[1,5-a]pyrazin-2-yl)-7-(1-methylpiperidin-4-yl)-4H-pyrazino[1,2-a]pyrimidin-4-one;2-(4, 6-dimethylpyrazolo[1,5-a]pyrazin-2-yl)-7-(1- ...

REFRIGERATOR

A refrigerator includes a cabinet that defines a lower storage space, a front panel door part, a drawer part connected to the front panel door part, a support member located at the drawer part and configured to seat one or more objects stored in the drawer part, at least one draw-out rail that is configured to connect the drawer part to an inner wall surface of the lower storage space, and that is configured to extend and retract in multiple stages to assist insertion and withdrawal of the drawer part based on movement of the front panel door part, and at least one elevation device that is located at each of both side surfaces of the drawer part, that is connected to each of both sides of the support member, and that is configured to elevate the support member relative to the drawer part. 1. A refrigerator , comprising:a cabinet that defines a storage space;a front door panel configured to open and close at least a portion of the storage space;an elevation motor installed on a rear surface of the front door panel;a door-side shaft is connected with the elevation motor;a drawer coupled to the front door panel and configured to insert into and withdraw from the storage space, the drawer being configured to accommodate a food container;an elevation device installed on the drawer and configured to elevate the food container,a drawer-side shaft connected to the elevation device; anda door-side shaft connected to the elevation motor;wherein the driving power of the elevation motor is transferred through the door-side shaft and the drawer-side shaft to the elevation device.2. The refrigerator according to claim 1 , further comprising a support member disposed in the drawer and configured to support the food container claim 1 ,wherein the elevation device is connected to ends of the support member and configured to elevate the support member relative to the bottom surface of the drawer.3. The refrigerator according to claim 1 , wherein the door-side shaft extends in a first ...

SYSTEM AND METHOD FOR PROVIDING MAGNETIC BASED NAVIGATION SYSTEM IN DENTAL IMPLANT SURGERY

A system and method for providing magnetic based navigation in dental implant surgery is disclosed. According to one embodiment, a surgical navigation system comprises a custom piece that is made to fit in a patient's anatomy and comprises a first magnetic component. The surgical navigation system further comprises an instrument assembly comprising a drill bit and a second magnetic component. A processing unit receives and displays a first position and orientation data from the first magnetic component with respect to a second position and orientation data from the second magnetic component to track the movement of the first magnetic component with respect to the second magnetic component. 1. A surgical navigation system comprising:a custom piece made to fit in a patient's anatomy, the custom piece comprising a first magnetic component;an instrument assembly comprising a drill bit and a second magnetic component;a processing unit receiving at least one of a first position and orientation data from the first magnetic component and a second position and orientation data from the second magnetic component; anda display displaying the at least one of the first position and orientation data of the first magnetic component and the second position and orientation data of the second magnetic component.2. The surgical navigation system of claim 1 , wherein the first magnetic component is a magnetic transmitter claim 1 , and the second magnetic component is a magnetic sensor.3. The surgical navigation system of claim 2 , wherein the magnetic sensor receives signal transmitted from the magnetic transmitter and determines the second position and orientation data based on the received signal from the magnetic transmitter.4. The surgical navigation system of claim 1 , wherein the first magnetic component is a magnetic sensor claim 1 , and the second magnetic component is a magnetic transmitter.5. The surgical navigation system of further comprising a magnetic transmitter claim 1 ...

METHOD OF PREPARING NEGATIVE ELECTRODE ACTIVE MATERIAL

The present invention relates to a method of preparing a negative electrode active material which includes forming a mixture by mixing LiO and SiO(0 Подробнее

SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS

Amine substituted pyridine and pyrazine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein. 2. The compound of claim 1 , wherein Ris optionally substituted heteroaryl or heterocyclyl selected from 1H-pyrazolyl claim 1 , 1H-imidazolyl claim 1 , 1 claim 1 ,2-oxazolyl claim 1 , pyridinyl claim 1 , 1H-indolyl claim 1 , 2H-indazolyl claim 1 , 4 claim 1 ,5 claim 1 ,6 claim 1 ,7-tetrahydro-2H-indazolyl claim 1 , 1H-benzimidazolyl claim 1 , imidazo[2 claim 1 ,1-b][1 claim 1 ,3]thiazolyl claim 1 , pyrazolo[1 claim 1 ,5-a]pyridinyl claim 1 , pyrazolo[1 claim 1 ,5-c]pyrimidinyl claim 1 , imidazo[1 claim 1 ,2-a]pyridinyl claim 1 , 5 claim 1 ,6 claim 1 ,7 claim 1 ,8-tetrahydroimidazo[1 claim 1 ,2-a]pyridinyl claim 1 , 1H-imidazo[4 claim 1 ,5-b]pyridinyl claim 1 , 1H-imidazo[4 claim 1 ,5-c]pyridinyl claim 1 , 4 claim 1 ,5 claim 1 ,6 claim 1 ,7-tetrahydro-3H-imidazo[4 claim 1 ,5-c]pyridinyl claim 1 , imidazo[1 claim 1 ,2-a]pyrazinyl claim 1 , imidazo[1 claim 1 ,2-a]pyrimidinyl claim 1 , 7H-purinyl or quinolinyl.3. A compound or a form thereof is selected from the group consisting of:6-(1H-benzimidazol-1-yl)-N-(4-methoxyphenyl)pyrazin-2-amine6-(1H-benzimidazol-1-yl)-N-(4-iodophenyl)pyrazin-2-amineN-(3-chloro-4-methoxyphenyl)-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyridin-2-amineN-(4-methoxyphenyl)-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyridin-2-amineN-(4-methoxyphenyl)-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrazin-2-amine6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amineN-(3-fluoro-4-methoxyphenyl)-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrazin-2-amineN-(3-fluoro-4-methoxyphenyl)-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyridin-2-amineN-(4- ...

NEGATIVE ELECTRODE ACTIVE MATERIAL, NEGATIVE ELECTRODE INCLUDING THE SAME AND LITHIUM SECONDARY BATTERY INCLUDING THE SAME

The present invention relates to a negative electrode active material which includes a secondary particle including a first particle which is a primary particle, wherein the first particle includes a first core and a first surface layer which is disposed on a surface of the first core and contains carbon, and the first core includes a metal compound which includes one or more of a metal oxide and a metal silicate and one or more of silicon and a silicon compound; a method of preparing the same; an electrode including the same; and a lithium secondary battery including the same. 1. A negative electrode active material , comprising a secondary particle including a first particle which is a primary particle and a second particle which is a primary particle ,wherein the first particle includes a first core, and a first surface layer which is disposed on a surface of the first core and contains carbon, andthe first core includes:one or more of silicon and a silicon compound; anda metal compound which includes one or more of a metal oxide and a metal silicate,wherein the secondary particle further includes a second particle which is a primary particle, the second particle includes a second core and a second surface layer which is disposed on a surface of the second core and contains carbon, and the second core includes one or more of silicon and a silicon compound.2. The negative electrode active material according to claim 1 , wherein the metal compound is doped in an amount of 1 to 50 wt % based on the total weight of the first particle.3. The negative electrode active material according to claim 1 , wherein a weight ratio of the first particle and the second particle is in a range of 1:0.25 to 1:4.4. The negative electrode active material according to claim 1 , wherein an average particle size Dof each of the first core and the second core is in a range of 0.5 to 20 μm.5. The negative electrode active material according to claim 1 , wherein the silicon included in each ...

NEGATIVE ELECTRODE ACTIVE MATERIAL, NEGATIVE ELECTRODE INCLUDING THE SAME, AND SECONDARY BATTERY INCLUDING THE NEGATIVE ELECTRODE

The present invention relates to a negative electrode active material including a carbonaceous matrix having a plurality of nano-particles, wherein the nano-particles have a silicon core, an oxide layer disposed on the silicon core and including SiO(0 Подробнее

PYRAZOLE DERIVATIVES AS TNIK, IKKe AND TBK1 INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Provided is pyrazole derivatives as a TNIK (Traf2- and NCK-interacting kinase), IKKε (I-kappa-B kinase epsilon) and TBK1 (TANK-binding kinase 1) inhibitor; the pyrazole derivative according to the present invention effectively inhibits TNIK, IKKε and TBK1, and thus is useful not only as an anticancer agent for the treatment of various cancers including colorectal cancer, breast cancer, CNS cancer, colon cancer, non-small cell lung cancer, kidney cancer, prostate cancer, ovarian cancer, uterus cancer, stomach cancer, liver cancer, skin cancer, lung cancer, brain cancer, bladder cancer, esophageal cancer, pancreatic cancer, thyroid cancer, head and neck cancer, squamous cell carcinoma, osteosarcoma, B-cell or T-cell lymphoma, acute or chronic leukemia and multiple myeloma, but as a therapeutic agent for chronic inflammation. 2. The compound of claim 1 , wherein Ris substituted or unsubstituted phenyl claim 1 , pyrazole or pyridine.3. The compound of claim 2 , wherein Ris phenyl which is substituted with at least one substituent selected from the group consisting of fluoro claim 2 , methoxy claim 2 , methylthio claim 2 , methyl claim 2 , tert-butyl claim 2 , methylpiperazinyl claim 2 , piperazinyl claim 2 , morpholino claim 2 , dimethylpiperazinyl claim 2 , dimethylmorpholino claim 2 , hydroxypiperidinyl claim 2 , ethylpiperazinyl claim 2 , methoxypiperidinyl claim 2 , methoxyethylamino claim 2 , methoxypropylamino claim 2 , pyrrolidinylethylamino claim 2 , morpholinoethylamino claim 2 , dimethylaminopropylamino claim 2 , methyl(methylaminoethylamino) claim 2 , tetrahydrofuranylmethylamino claim 2 , dimethylamino ethylamino claim 2 , isopentylamino claim 2 , tetrahydropyranyl ethylamino claim 2 , hexylamino claim 2 , cyclohexylamino claim 2 , cyclopentylamino claim 2 , cycloheptylamino claim 2 , cyclooctylamino claim 2 , cyclohexylmethylamino claim 2 , cyclohexenylethylamino claim 2 , pyrrolylethylamino claim 2 , tert-butyloxy carbonyl tetrahydropyridinyl claim 2 , ...

7-AZAINDOLE OR 4,7-DIAZAINDOLE DERIVATIVES AS IKK EPSILON AND TBK1 INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Provided are 7-azaindole or 4,7-diazaindole derivatives as an IKKε (I-kappa-B kinase epsilon) and TBK1 (TANK-binding kinase 1) inhibitor. The 7-azaindole or 4,7-diazaindole derivative effectively inhibits IKKε and TBK1, and thus is useful not only as an anticancer agent for the treatment of various cancers including colorectal cancer, breast cancer, CNS cancer, colon cancer, non-small cell lung cancer, kidney cancer, prostate cancer, ovarian cancer, uterus cancer, stomach cancer, liver cancer, skin cancer, lung cancer, brain cancer, bladder cancer, esophageal cancer, pancreatic cancer, thyroid cancer, head and neck cancer, squamous cell carcinoma, osteosarcoma, B-cell or T-cell lymphoma, acute or chronic leukemia and multiple myeloma, but as a therapeutic agent for chronic inflammation. 2. The compound of claim 1 , wherein the ring A is benzene.4. The compound of claim 1 , wherein Ris H claim 1 , halogen claim 1 , substituted or unsubstituted phenyl claim 1 , substituted or unsubstituted thiophenyl claim 1 , substituted or unsubstituted isoindolinonyl claim 1 , substituted or unsubstituted pyridinyl claim 1 , substituted or unsubstituted furanyl claim 1 , substituted or unsubstituted benzodioxolyl claim 1 , substituted or unsubstituted thiadiazolyl claim 1 , substituted or unsubstituted indazolyl or substituted or unsubstituted oxoisoindolinyl5. The compound of claim 4 , wherein the phenyl claim 4 , thiophenyl claim 4 , isoindolinonyl claim 4 , pyridinyl claim 4 , furanyl claim 4 , benzodioxolyl claim 4 , thiadiazolyl claim 4 , indazolyl or oxoisoindolinyl is substituted with one or more substituents selected from the group consisting of fluoro claim 4 , chloro claim 4 , amino claim 4 , tetrahydro-2H-pyran-amino claim 4 , cyano claim 4 , acetyl claim 4 , acetamido claim 4 , methylsulfonamido claim 4 , methyl claim 4 , morpholinomethyl claim 4 , piperazinylmethyl claim 4 , methylpiperazinylmethyl claim 4 , ethylpiperazinylmethyl claim 4 , pyrrolidinylmethyl claim 4 , ...

NEGATIVE ELECTRODE ACTIVE MATERIAL, NEGATIVE ELECTRODE INCLUDING THE NEGATIVE ELECTRODE ACTIVE MATERIAL, AND SECONDARY BATTERY INCLUDING THE NEGATIVE ELECTRODE

The present invention relates to a negative electrode active material which includes a carbonaceous matrix including a first particle and a second particle, wherein the first particle includes a silicon core, an oxide layer which is disposed on the silicon core and includes SiO(0 Подробнее

ADJUSTABLE ANATOMY DISPLAY TABLE

An adjustable anatomy display table is disclosed. According to one embodiment, the adjustable anatomy table includes a display configured to visualize the anatomy in a real size, a base configured to support the display, and an adjustable mechanism that mechanically couples the display to the base. The adjustable mechanism is configured to adjust a position of the display relative to the base. 1. An imaging system comprising:a display configured to visualize an image of an anatomy in a real size;a base configured to support the display; andan adjustable mechanism that mechanically couples the display to the base,wherein the adjustable mechanism is configured to adjust a position of the display relative to the base.2. The imaging system of claim 1 , wherein the adjustable mechanism is a tilting mechanism that is configured to tilt the display from a horizontal position to an upright position.3. The imaging system of claim 1 , wherein the adjustable mechanism is a rotational mechanism that is configured to rotate the display about a rotational axis.4. The imaging system of claim 1 , wherein the adjustable mechanism is a height adjusting mechanism that is configured to adjust a height of the display.5. The imaging system of further comprises a second adjustable mechanism that is selected from a group comprising a tilting mechanism that is configured to tilt the display from a horizontal position to an upright position claim 1 , a rotational mechanism that is configured to rotate the display about a rotational axis claim 1 , and a height adjusting mechanism that is configured to adjust a height of the display.6. The imaging system of claim 1 , wherein the anatomy is a human anatomy claim 1 , and wherein the display is configured to visualize the human anatomy from a head to a toe.7. The imaging system of claim 1 , wherein the imaging system is configured to receive an input from a user claim 1 , and wherein the input from the user comprises an input to dissect claim 1 , ...

NEGATIVE ELECTRODE ACTIVE MATERIAL, NEGATIVE ELECTRODE INCLUDING THE SAME, AND SECONDARY BATTERY INCLUDING THE NEGATIVE ELECTRODE

A negative electrode active material including a core having SiO(0≤x<2), an intermediate layer covering at least a portion of a surface of the core and including at least one of silicon nitride or silicon oxynitride, and a carbon coating layer covering at least a portion of the intermediate layer and containing nitrogen. 1. A negative electrode active material , comprising:{'sub': 'x', 'a core including SiO(0≤x<2);'}an intermediate layer covering at least a portion of a surface of the core and including at least one of silicon nitride or silicon oxynitride; anda carbon coating layer covering at least a portion of the intermediate layer and containing nitrogen.2. The negative electrode active material of claim 1 , wherein an average particle diameter (D) of the core is 0.1 μm to 100 μm.3. The negative electrode active material of claim 1 , wherein the core further comprises a metal compound claim 1 , and wherein the metal compound comprises at least one of a metal oxide or a metal silicate.4. The negative electrode active material of claim 3 , wherein the metal compound is the metal oxide and the metal oxide comprises one or two or more oxides selected from the group consisting of Li claim 3 , Mg claim 3 , Al claim 3 , Ca claim 3 , and Ti.5. The negative electrode active material of claim 3 , wherein the metal compound is the metal silicate and the metal silicate includes one or two or more silicates selected from the group consisting of Li claim 3 , Mg claim 3 , Al claim 3 , Ca claim 3 , and Ti.6. The negative electrode active material of claim 3 , wherein the metal compound is included in an amount of 1 wt % to 60 wt % based on a total weight of the core.7. The negative electrode active material of claim 1 , wherein a thickness of the intermediate layer is 1 nm to 100 nm.8. The negative electrode active material of claim 1 , wherein a thickness of the carbon coating layer is 1 nm to 100 nm.9. The negative electrode active material of claim 1 , wherein the nitrogen ...

COMPOUNDS AS TNIK, IKKEPSILON AND TBK1 INHIBITORS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Provided is a compound of formula (I) as a TNIK (Traf2- and NCK-interacting kinase), IKKε (I-kappa-B kinase epsilon) and TBK1 (TANK-binding kinase 1) inhibitor; the compound according to the present invention effectively inhibits TNIK, IKKε and TBK1, and thus is useful not only as an anticancer agent for the treatment of various cancers including colorectal cancer, breast cancer, CNS cancer, colon cancer, non-small cell lung cancer, kidney cancer, prostate cancer, ovarian cancer, uterus cancer, stomach cancer, liver cancer, skin cancer, lung cancer, brain cancer, bladder cancer, esophageal cancer, pancreatic cancer, thyroid cancer, head and neck cancer, squamous cell carcinoma, osteosarcoma, B-cell or T-cell lymphoma, acute or chronic leukemia and multiple myeloma, but as a therapeutic agent for chronic inflammation. 2. The compound of claim 1 , wherein Ris pyrrolidine.3. The compound of claim 1 , wherein Ris —NH—C(═O)—R claim 1 , Rbeing Calkyl claim 1 , substituted or unsubstituted phenyl claim 1 , substituted or unsubstituted thiophenyl claim 1 , substituted or unsubstituted furanyl claim 1 , substituted or unsubstituted pyridinyl or substituted or unsubstituted pyrrolidinyl.4. The compound of claim 3 , wherein said phenyl claim 3 , thiophenyl claim 3 , furanyl claim 3 , pyridinyl or pyrrolidinyl is substituted with one or more substituents selected from the group consisting of fluoro claim 3 , chloro claim 3 , bromo claim 3 , nitro claim 3 , cyano claim 3 , amino claim 3 , tertbutyloxycarbonyl claim 3 , methyl claim 3 , methylthio claim 3 , methylsulfonyl claim 3 , methoxy claim 3 , acetamido claim 3 , methylpiperazinyl claim 3 , aminopiperidinyl claim 3 , morpholino claim 3 , morpholinoethoxy claim 3 , methylamino claim 3 , dimethylamino claim 3 , dimethylaminoethylamino claim 3 , dimethylaminopropylamino claim 3 , aminoethylamino claim 3 , hydroxyethylamino claim 3 , hydroxypropylamino claim 3 , hydroxybutylamino claim 3 , methoxyethylamino claim 3 , ...

REFRIGERATOR

A refrigerator includes: a cabinet; a drawer door assembly including a front panel door part and a drawer part that defines an accommodation space; a rail that movably configured to connect the drawer door assembly to the cabinet and enable the drawer door assembly to insert into and withdraw from the cabinet; a driving device located at the front panel door part and configured to provide power; and an elevation device located in the drawer part and configured to be coupled to the driving device and elevate a portion of the drawer part relative to the front panel door part. The driving device includes: a motor assembly configured to provide driving force; a screw assembly configured to perform an elevation operation based on the driving force; and a lever that connects the screw assembly to the elevation device and that is configured to rotate based on the elevation operation. 1. A refrigerator comprising:a cabinet that defines a storage space;a drawer door assembly comprising (i) a front panel door part that is configured to open and close at least a portion of the storage space and (ii) a drawer part that defines an accommodation space;a rail that is configured to movably connect the drawer door assembly to the cabinet and enable the drawer door assembly to insert into and withdraw from the storage space;a driving device located at the front panel door part and configured to provide power; andan elevation device located in the drawer part and configured to be coupled to the driving device, the elevation device being configured to elevate a portion of the drawer part relative to the front panel door part, a motor assembly configured to provide a driving force;', 'a screw assembly configured to perform an elevation operation based on the driving force from the motor assembly; and', 'a lever that connects the screw assembly to the elevation device and that is configured to rotate based on the elevation operation of the screw assembly., 'wherein the driving device ...

REFRIGERATOR

A refrigerator includes a cabinet that defines a lower storage space, a front panel door part configured to open and close the lower storage space, a drawer part connected to the front panel door part, a support member located at the drawer part, and an elevation assembly located at the front panel door part and configured to elevate the support member relative to the drawer part. The elevation assembly includes at least one elevation member that extends from the front panel door part to the drawer part and that passes through the drawer part, and a driving device that is located in the front panel door part, that is configured to provide power to the at least one elevation member, and that is configured to cause a vertical movement of the at least one elevation member relative to the drawer part. 1. A refrigerator comprising:a cabinet that defines an upper storage space and a lower storage space;a front panel door part configured to open and close at least a portion of the lower storage space;a drawer part connected to the front panel door part and configured to insert into and withdraw from the lower storage space together with the front panel door part;a support member located at the drawer part and configured to seat an object stored in the drawer part; andan elevation assembly located at the front panel door part and configured to elevate the support member relative to the drawer part, at least one elevation member that extends from the front panel door part to the drawer part, that is configured to pass through at least a portion of the drawer part, and that is located vertically below the support member, with the at least one elevation member being configured to support the support member; and', 'a driving device that is located in the front panel door part, that is configured to provide power to the at least one elevation member, and that is configured to cause a vertical movement of the at least one elevation member relative to the drawer part., 'wherein ...

NEGATIVE ELECTRODE ACTIVE MATERIAL FOR LITHIUM SECONDARY BATTERY, METHOD OF PREPARING THE SAME, AND LITHIUM SECONDARY BATTERY INCLUDING THE MATERIAL

Provided are a negative electrode active material for a lithium secondary battery and a method of preparing the same, wherein since the negative electrode active material includes porous polycrystalline silicon and the porous polycrystalline silicon includes pores disposed at grain boundaries, the negative electrode active material may exhibit a buffering action by internally absorbing changes in volume of the active material during charge and discharge. As a result, lifetime characteristics of a negative electrode and a battery may be improved. 1. A negative electrode active material for a lithium secondary battery , the negative electrode active material comprising:porous polycrystalline silicon,wherein the porous polycrystalline silicon comprises pores disposed at grain boundaries.2. The negative electrode active material for a lithium secondary battery of claim 1 , wherein the porous polycrystalline silicon further comprises pores formed on a surface of the porous polycrystalline silicon.3. The negative electrode active material for a lithium secondary battery of claim 1 , wherein the porous polycrystalline silicon has a porosity of 5 vol % to 80 vol %.4. The negative electrode active material for a lithium secondary battery of claim 1 , wherein the porous polycrystalline silicon has an average grain size of 3 nm to 300 nm.5. The negative electrode active material for a lithium secondary battery of claim 1 , wherein the porous polycrystalline silicon has an average particle diameter (D) of 0.01 μm to 50 μm.6. The negative electrode active material for a lithium secondary battery of claim 1 , wherein the porous polycrystalline silicon comprises a metal impurity in an amount of 2 claim 1 ,000 ppm or less.7. The negative electrode active material for a lithium secondary battery of claim 1 , wherein the porous polycrystalline silicon does not comprise a metal impurity.8. The negative electrode active material for a lithium secondary battery of claim 1 , further ...

NEGATIVE ELECTRODE ACTIVE MATERIAL, NEGATIVE ELECTRODE INCLUDING THE NEGATIVE ELECTRODE ACTIVE MATERIAL, AND SECONDARY BATTERY INCLUDING THE NEGATIVE ELECTRODE

A negative electrode active material which includes a core including SiO(0 Подробнее

NEGATIVE ELECTRODE ACTIVE MATERIAL, METHOD OF PREPARING THE SAME, NEGATIVE ELECTRODE INCLUDING THE SAME AND LITHIUM SECONDARY BATTERY INCLUDING THE SAME

The present invention relates to a negative electrode active material including a secondary particle in which primary particles are aggregated, wherein the primary particle includes: a core including one or more of silicon and a silicon compound; and a surface layer which is disposed on a surface of the core and contains carbon, wherein an average particle size Dof the core is in a range of 0.5 μm to 20 μm, a method of preparing the same, an electrode including the same, and a lithium secondary battery including the same. 1. A negative electrode active material , comprising a secondary particle in which primary particles are aggregated ,wherein the primary particle includes:a core including one or more of silicon and a silicon compound; anda surface layer which is disposed on a surface of the core and contains carbon,{'sub': '50', 'wherein an average particle size Dof the core is in a range of 0.5 μm to 20 μm.'}2. The negative electrode active material according to claim 1 , wherein the silicon compound is a silicon oxide (SiO claim 1 , 0 Подробнее

Polymer

The present application relates to a polymer and a use thereof. The present application may provide a functional polymer which expresses a low solubility to a polar solvent and a non-polar solvent and which is suitable for forming a film. If applied to the use of cosmetics such as mascara or to medical uses, the polymer in the present application may express a tolerance to diverse solvents such as sebum, sweat, tears and the like, and thus enables makeup to last, etc. Accordingly, the polymer may be applied to diverse uses and used in film forming agents, cosmetic compositions, or cosmetics, or the like.

NEGATIVE ELECTRODE ACTIVE MATERIAL, NEGATIVE ELECTRODE INCLUDING THE SAME AND LITHIUM SECONDARY BATTERY INCLUDING THE SAME

The present invention relates to a negative electrode active material which includes a secondary particle including a first particle which is a primary particle, wherein the first particle includes a first core and a first surface layer which is disposed on a surface of the first core and contains carbon, and the first core includes a metal compound which includes one or more of a metal oxide and a metal silicate and one or more of silicon and a silicon compound; a method of preparing the same; an electrode including the same; and a lithium secondary battery including the same. 1. A negative electrode active material , comprising a secondary particle including a first , particle which is a primary particle ,wherein, the first particle includes a first core, and a first surface layer which is disposed on a surface of the first core and contains carbon, andthe first core includes:one or more of silicon and a silicon compound; anda metal compound which includes one or more of a metal oxide and a metal silicate.2. The negative electrode active material according to claim 1 , wherein the metal compound is doped in an amount of 1 to 50 wt % based on the total weight of the first particle.3. The negative electrode active material according claim 1 , to claim 1 , wherein the secondary particle flintier includes a second particle which is a primary particle claim 1 , the second particle includes a second core and a second surface layer which is disposed on a surface of the second core and contains carbon claim 1 , and the second core includes one or more of silicon and a silicon compound.4. The negative electrode active material according to claim 3 , wherein a weight ratio of the first particle and the second particle is in a range of 1:0.25 to 1:4.5. The negative electrode active material according to claim 3 , wherein an average particle size Dof each of the first core and the second core is in a range of 0.5 to 20 μm.6. The negative electrode active material according to ...

NOVEL ANTI-MESOTHELIN ANTIBODY AND COMPOSITION COMPRISING THE SAME

The present invention relates to an antibody specifically bound to mesothelin (MSLN), a nucleic acid encoding the antibody, a vector and a host cell including the nucleic acid, a method for producing the antibody, and a pharmaceutical composition for treating cancer or tumor including the antibody as an active ingredient. The antibody specifically bound to the mesothelin according to the present invention has high affinity and specificity to an antigen, such that it is possible to develop an antibody effectively usable for treatment or diagnosis of cancer or tumor diseases. 1. An antibody binding to mesothelin comprising a heavy chain variable region comprising a heavy chain CDR comprising:a heavy chain CDR1 comprising an amino acid sequence of SEQ ID NO: 9, 15, 21, 27, or 59;a heavy chain CDR2 comprising an amino acid sequence of SEQ ID NO: 10, 16, 22, 28, 60, 65, 71, 75, 80, 84, 121, 122, 123 or 125; anda heavy chain CDR3 comprising an amino acid sequence of SEQ ID NO: 11, 17, 23, 29, 61, 66, 72, 76, 81, 85, 124 or 126.2. An antibody binding to mesothelin comprising a light chain variable region comprising a light chain CDR comprising:a light chain CDR1 comprising an amino acid sequence of SEQ ID NO: 12, 18, 24, 30, 62, 67, 70, 77, 86 or 117;a light chain CDR2 comprising an amino acid sequence of SEQ ID NO: 13, 19, 25, 63, 68, 73, 78 or 82; anda light chain CDR3 comprising an amino acid sequence of SEQ ID NO: 14, 20, 26, 64, 69, 74, 79, 83, 87, 118, 119 or 120.3. The antibody of claim 1 , wherein the heavy chain variable region comprises an amino acid sequence of SEQ ID NO: 1 claim 1 , 3 claim 1 , 5 claim 1 , 7 claim 1 , 46 claim 1 , 48 claim 1 , 51 claim 1 , 53 claim 1 , 55 claim 1 , 57 claim 1 , 112 claim 1 , 113 claim 1 , 114 claim 1 , 115 or 116 claim 1 , or an amino acid sequence having a sequence homology thereto of at least 80%.4. The antibody of claim 1 , wherein the light chain variable region comprises an amino acid sequence of SEQ ID NO: 2 claim 1 , 4 ...

NOVEL ANTI-GLYPICAN 3 ANTIBODY AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

The present invention relates to an antibody specifically binding to glypican 3 (GPC3), a nucleic acid encoding the antibody, a vector and a host cell containing the nucleic acid, a method of preparing the antibody, and a pharmaceutical composition for treating cancer or tumor, containing the antibody as an active ingredient. The antibody specifically binding to glypican 3 according to the present invention may be effectively used to treat cancer or tumor, particularly, hepatocellular carcinoma due to high affinity and specificity to glypican 3. 1. An anti-glypican 3 antibody comprising a heavy chain variable region comprising the following heavy chain CDRs:a heavy chain CDR1 comprising an amino acid sequence of SEQ ID NO: 133, 143, 149, 159, 169, 174, 184, 199, 262, 268, 273, 281, 285, 291, 297, 308, 353, 363, 374, 380, or 386;a heavy chain CDR2 comprising an amino acid sequence of SEQ ID NO:134, 144, 150, 160, 170, 175, 185, 200, 231, 263, 266, 269, 274, 282, 286, 292, 298, 303, 309, 314, 318, 323, 328, 331, 336, 341, 345, 349, 354, 359, 364, 369, 375, 381, or 387; anda heavy chain CDR3 comprising an amino acid sequence of SEQ ID NO: 135, 139, 145, 151, 155, 161, 165, 171, 176, 180, 186, 189, 194, 195, 201, 205, 207, 210, 214, 218, 222, 227, 232, 237, 239, 243, 247, 250, 254, 258, 259, 264, 267, 270, 275, 278, 279, 283, 287, 293, 299, 304, 310, 315, 319, 324, 329, 332, 337, 342, 346, 350, 355, 360, 365, 370, 376, 382, or 388, ora light chain variable region comprising the following light chain CDRs:a light chain CDR1 comprising an amino acid sequence of SEQ ID NO: 136, 140, 146, 152, 156, 162, 166, 172, 177, 181, 187, 190, 193, 196, 202, 208, 211, 215, 219, 223, 224, 228, 233, 240, 244, 251, 255, 260, 265, 271, 288, 294, 300, 305, 311, 316, 320, 325, 333, 338, 343, 347, 356, 361, 366, 371, 377, 383, or 389;a light chain CDR2 comprising an amino acid sequence of SEQ ID NO: 137, 141, 147, 153, 157, 163, 167, 178, 182, 191, 197, 203, 209, 212, 216, 220, 225, 229, 234 ...

Antibody-linker-drug conjugate, preparation method therefor, and anticancer drug composition containing same

The present invention relates to an antibody-linker-drug conjugate in which an antibody and a cytotoxic drug are conjugated through an enzyme cleavable peptide linker capable of directly binding to a lysine residue of an antibody, a preparation method therefor, and an anticancer drug composition containing the same as an active ingredient.

NEGATIVE ELECTRODE ACTIVE MATERIAL, NEGATIVE ELECTRODE INCLUDING THE SAME, AND SECONDARY BATTERY INCLUDING THE NEGATIVE ELECTRODE

The present invention relates to a negative electrode active material including a spherical carbon-based particle, and a carbon layer disposed on the spherical carbon-based particle and including a nano-particle, wherein the nano-particle has a silicon core, an oxide layer disposed on the silicon core and including SiO(0 Подробнее

REFRIGERATOR

A refrigerator includes a cabinet that defines a lower storage space, a front panel door part, a drawer part connected to the front panel door part, a support member located at the drawer part and configured to seat one or more objects stored in the drawer part, at least one draw-out rail that is configured to connect the drawer part to an inner wall surface of the lower storage space, and that is configured to extend and retract in multiple stages to assist insertion and withdrawal of the drawer part based on movement of the front panel door part, and at least one elevation device that is located at each of both side surfaces of the drawer part, that is connected to each of both sides of the support member, and that is configured to elevate the support member relative to the drawer part. 1. A refrigerator , comprising:a cabinet that defines an upper storage space and a lower storage space;a front panel door part configured to open and close at least a portion of the lower storage space by moving away from and toward the lower storage space, respectively;a drawer part that is connected to the front panel door part, that is configured to insert into the lower storage space based on the front panel door part moving toward the lower storage space, and that is configured to withdraw from the lower storage space based on the front panel door part moving away from the lower storage space, the drawer part defining a drawer space therein;a support member located at the drawer part and configured to seat one or more objects stored in the drawer part;at least one draw-out rail that is configured to connect the drawer part to an inner wall surface of the lower storage space, and that is configured to extend and retract in multiple stages to assist insertion and withdrawal of the drawer part based on movement of the front panel door part; andat least one elevation device that is located at each of both side surfaces of the drawer part, that is connected to each of both sides of ...

VIRTUAL FLYING CAMERA SYSTEM

A virtual flying camera system is disclosed. According to one embodiment, a system includes: a video buffer configured to store input video streams from a plurality of cameras; and a video processor configured to generate an output video stream from the input video streams. The input video streams include a plurality of input video frames, each of the plurality of input video frames includes at least a partial image of a moving target. The output video stream includes a plurality of output video frames, each of the plurality of output video frames is generated by shifting a corresponding input video stream to position the moving target at a desired location within the output video frame, The output video stream is playable at a user-adjustable speed showing a view of a virtually flying camera that follows the moving target at the desired location within each of the plurality of output video frames. 1. A system comprising:a video buffer configured to store input video streams from a plurality of cameras; anda video processor configured to generate an output video stream from the input video streams,wherein the input video streams comprise a plurality of input video frames, each of the plurality of input video frames includes at least a partial image of a moving target, wherein the output video stream comprises a plurality of output video frames, each of the plurality of output video frames is generated by shifting a corresponding input video stream to position the moving target at a desired location within the output video frame, andwherein the output video stream is playable at a user-adjustable speed showing a view of a virtually flying camera that follows the moving target at the desired location within each of the plurality of output video frames.2. The system of claim 1 , wherein at least some of the plurality of input video frames include a reference object that has a known distance from the plurality of cameras claim 1 , and wherein the video processor ...

Bladder monitoring system

A bladder monitoring system includes a scanning system and a wearable bladder monitoring device (or patch). The scanning system obtains scan data that shows a bladder in a patient and identifies, based on the scan data, a placement location on the patient for the wearable bladder monitoring device. The scanning system indicates the placement location to a user; and identifies customization settings for one or more sensors of the wearable bladder monitoring device to enable the one or more sensors to detect extents of the bladder when the wearable bladder monitoring device is attached at the placement location.

SILICON-BASED PARTICLE-POLYMER COMPOSITE AND NEGATIVE ELECTRODE ACTIVE MATERIAL COMPRISING THE SAME

The present invention relates to a silicon-based particle-polymer composite, which includes silicon-based particles; and a polymer coating layer formed on the silicon-based particles, in which the polymer coating layer includes metal-substituted poly(acrylic acid) in which hydrogen atoms in carboxyl groups of the poly(acrylic acid) chain are substituted with one or more selected from the group consisting of K, Na and Li. 1. A silicon-based particle-polymer composite , comprising:silicon-based particles; anda polymer coating layer formed on the silicon-based particles,wherein the polymer coating layer comprises a metal-substituted poly(acrylic acid) in which hydrogen atoms of carboxyl groups are substituted with one or more selected from the group consisting of K, Na and Li.2. The composite according to claim 1 , wherein 10 to 100% of the hydrogen atoms are substituted with K claim 1 , Na or Li.3. The composite according to claim 1 , wherein the polymer coating layer comprises the metal-substituted poly(acrylic acid) in which the hydrogen atoms are substituted with Na.4. The composite according to claim 1 , wherein the polymer coating layer comprises the metal-substituted poly(acrylic acid) in which 50 to 100% of the hydrogen atoms are substituted with Na.5. The composite according to claim 1 , wherein the polymer coating layer comprises the metal-substituted poly(acrylic acid) in which 70 to 90% of the hydrogen atoms are substituted with Na.6. The composite according to claim 1 , wherein the silicon-based particles comprise a mixture of one or more selected from the group consisting of Si claim 1 , silicon oxide particles (SiO claim 1 , 0 Подробнее

COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. 115-. (canceled)17. The method of claim 16 , wherein Ris heteroaryl selected from furo[3 claim 16 ,2-b]pyridinyl claim 16 , furo[3 claim 16 ,2-c]pyridinyl claim 16 , furo[2 claim 16 ,3-c]pyridinyl claim 16 , thieno[3 claim 16 ,2-c]pyridinyl claim 16 , thieno[2 claim 16 ,3-d]pyrimidinyl claim 16 , 1H-pyrrolo[2 claim 16 ,3-b]pyridinyl claim 16 , 1H-pyrrolo[2 claim 16 ,3-c]pyridinyl claim 16 , pyrrolo[1 claim 16 ,2-a]pyrimidinyl claim 16 , pyrrolo[1 claim 16 ,2-a]pyrazinyl claim 16 , pyrrolo[1 claim 16 ,2-b]pyridazinyl claim 16 , pyrazolo[1 claim 16 ,5-a]pyridinyl claim 16 , pyrazolo[1 claim 16 ,5-a]pyrazinyl claim 16 , imidazo[1 claim 16 ,2-a]pyridinyl claim 16 , imidazo[1 claim 16 ,2-a]pyrimidinyl claim 16 , imidazo[1 claim 16 ,2-c]pyrimidinyl claim 16 , imidazo[1 claim 16 ,2-b]pyridazinyl claim 16 , imidazo[1 claim 16 ,2-a]pyrazinyl claim 16 , imidazo[2 claim 16 ,1-b][1 claim 16 ,3]thiazolyl claim 16 , imidazo[2 claim 16 ,1-b][1 claim 16 ,3 claim 16 ,4]thiadiazolyl claim 16 , [1 claim 16 ,3]oxazolo[4 claim 16 ,5-b]pyridinyl and quinoxalinyl; wherein claim 16 , each instance of heteroaryl is optionally substituted with one claim 16 , two or three Rsubstituents and optionally claim 16 , with one additional Rsubstituent.18. The method of claim 16 , wherein Ris Calkyl selected from methyl claim 16 , ethyl claim 16 , propyl claim 16 , isopropyl and tert-butyl.19. The method of claim 16 , wherein Ris Calkyl selected from methyl claim 16 , ethyl claim 16 , propyl claim 16 , isopropyl and tert-butyl.20. The method of claim 16 , wherein Ris claim 16 , in each instance claim 16 , hydrogen.21. The method of claim 16 , wherein Ris Calkyl.22. The method of claim 16 , wherein Ris hydrogen or Calkyl.23. The method of claim 16 , wherein the salt form is a chloride claim 16 , hydrobromide claim 16 , hydrochloride claim 16 , dihydrochloride claim 16 , acetate claim 16 , ...

METHOD FOR PRODUCING DIPHENYLMETHANE DERIVATIVE

The present invention relates to an improved method for producing a diphenylmethane derivative which is effective as a sodium-dependent glucose cotransporter (SGLT) inhibitor, the method being carried out by means of a convergent synthesis method in which each major group is separately synthesized and then coupled. As such, in comparison to a linear synthesis method disclosed in existing documents, the synthesis pathway is compact and yield can be increased, and risk factors inherent in the linear synthesis pathway can be reduced. Furthermore, the crystal form of the compound produced according to the method has superb physicochemical characteristics, and thus can be effectively utilized in fields such as pharmaceutical manufacturing. 3. The method for producing the compound of Formula 1a according to claim 2 ,wherein the cyclization reaction is a cyclization reaction using a Vilsmeier reagent, a cyclization reaction using a leaving group, a cyclization reaction using a halide, or a cyclization reaction using a Mitsunobu reaction.6. The method for producing the compound of Formula 1a according to claim 1 ,{'sub': '1-7', 'wherein the method further comprises an alkylation reaction after the step (3), and X′ is Calkyl.'}7. The method for producing the compound of Formula 1a according to claim 1 ,wherein the step (3) further includes isolating only a compound in which glucose is in a β-form, after or during the deprotection and reduction process.11. The method for producing the compound of Formula 1a according to claim 9 , wherein each of the compound of Formula 7 and n-butyllithium is used in an amount of 1.5 to 2.5 equivalents with respect to 1 equivalent of the compound of Formula 6.12. The method for producing the compound of Formula 1a according to claim 1 ,wherein the method further comprises a step of performing crystallization using a solvent selected from the group consisting of toluene, ethyl acetate, dichloromethane, a mixture of tetrahydrofuran and ...

Mixed supported metallocene catalyst, method of preparing the same, method of preparing polyolefin using the mixed supported metallocene catalyst, and polyolefin prepared using the method of preparing polyolefin using the mixed supported metallocene cata

Method of forming extruded polystyrene foams and the products made therefrom

The invention a method of forming complex shape of styrenic polymer foams in which a pressing surface is created, for example, by planing/machining a layer of an as formed extruded styrenic polymer plank, contacting said plank with a contoured die face and pressing the foam to form the complex shape.

Inhibitors of mtor and methods of treatment using same

The present invention provides novel compounds that inhibit mTOR activity. Compositions, including pharmaceutical compositions, comprising compounds of the present invention are also provided. The present invention also provides methods of treatment comprising administering compositions of the present invention to a subject in need thereof.