04-05-2018 дата публикации
Номер: KR1020180045344A
Принадлежит:
The present invention relates to a composition for enhancing migration or differentiation of stem cells, comprising colony stimulating factor-2 (CSF-2) protein as an effective component, and to a method for culturing stem cells with enhanced migration and differentiation potentials. In the present invention, it was confirmed that the CSF-2 protein, when used to treat adult stem cells, adipose-derived mesenchymal stem cells, increases stemness, and that when culturing by adding the protein to an osteoclast differentiation culture, osteoblast differentiation potential is greatly enhanced. In addition, it was confirmed that the expression of EMT markers including fibronectin (FN 1), snail, twist, and vimentin is significantly increased, and thus greatly improves migration potential, and at the same time, that cytoskeletal proteins of stem cells are rearranged into a spindle shape. Thus, the CSF-2 protein can be beneficially used as a composition for enhancing the therapeutic effect of stem ...
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