04-07-2013 дата публикации
Номер: US20130172354A1
Автор:
Barsanti Paul A.,
Hu Cheng,
Jin Jeff,
Keyes Robert,
Kucejko Robert,
Lin Xiaodong,
Pan Yue,
Pfister Keith B.,
Sendzik Martin,
Sutton James,
Wan Lifeng
The present invention provides a compound of formula (I): 2. The method of claim 1 , wherein:{'sub': '8', 'Ris Cl.'}3. The method of claim 1 , wherein:{'sub': 1', '16, 'Ris X—R;'}{'sub': '1-2', 'X is a bond, or Calkyl;'}{'sub': 16', '1-2', '4-6, 'Ris selected from the group consisting of C-alkyl, Ccycloalkyl, heterocycloalkyl, phenyl, and heteroaryl;'}{'sub': 16', '1-3', '3-6', '1-2', '22', '12', '1-2', '12', '12', '22', '12', '19', '22', '19', '13', '14', '15', '2', '12', '17', '18', '22', '17', '18', '15', '19', '22', '15', '19', '15', '2, 'wherein Ris substituted with one to three groups independently selected from halogen, hydrogen, Calkyl, Cbranched alkyl, OH, Calkoxy, R—OR, S(O)R, C(O)OR, R—C(O)OR, C(O)R, R—OC(O)R, C(O)NRR, NRS(O)R, NRR, R—NRR, NRC(O)R, R—NRC(O)R, and NRC(O)OCHPh.'}5. The method of wherein:{'sub': 3', '2, 'Ris selected from H, methyl, cyano, chloro, CONH, amino, cyclopropyl, ethyl, and fluoro;'}{'sub': '4', 'Ris selected from halogen, methyl, hydrogen, and halo-methyl;'}{'sub': '6', 'Ris H;'}{'sub': 7', '2', '3, 'Ris selected from H, COOH, Cl, F, CONH, CN, and CF;'}{'sub': '8', 'Ris Cl;'}{'sub': 17', '18', '1-3', '1-4', '3-6', '22', '12', '22', '2', '12', '22', '15', '2', '12', '17', '18', '20', '21, 'Rand Rare each, independently, selected from the group consisting of hydrogen, Calkyl, Chaloalkyl, Cbranched alkyl, R—OR, R—S(O)R, R—NRS(O)R, heterocycloalkyl or heteroaryl; alternatively, Rand Ralong with the nitrogen atom to which they are attached to can be taken together to form a four to six membered heterocyclic ring wherein said ring carbon atoms are optionally substituted with R, and the ring nitrogen atoms are optionally substituted with R;'}{'sub': 19', '1-3, 'Ris selected from C-alkyl, optionally substituted heterocycloalkyl, optionally substituted aryl or optionally substituted heteroaryl;'}{'sub': 20', '1-3, 'Rrepresents the group Calkyl; and'}{'sub': 22', '1-4', '3-6, 'Ris selection from the group consisting of Calkyl, and Cbranched ...
Подробнее
