МАТЕРИАЛ НА ОСНОВЕ ОКСИДА КРЕМНИЯ

Изобретение относится к области хроматографии. Предложен органо-модифицированный материал на основе оксида кремния, используемый для изготовления неподвижной фазы для жидкостной хроматографии, который содержит часть, представляющую собой немодифицированный оксид кремния, и часть, которая представляет собой оксид кремния, содержащий органические группы, в частности алкильные группы, алкенильные группы или алкинильные группы, связанные с атомами кремния. Предложен способ приготовления органо-модифицированного материала на основе оксида кремния, предусматривающий смешивание материала на основе оксида кремния и органосиланового соединения и осуществление взаимодействия в полученной смеси. Описаны характеристики разделяющего материала для неподвижной фазы, который приготовлен путем функционализации органо-модифицированного материала на основе оксида кремния. Изобретение обеспечивает получение материала с высокой химической и механической стабильностью. 9 н. и 18 з.п. ф-лы, 7 табл., 4 ил.

МАТЕРИАЛ НА ОСНОВЕ ОКСИДА КРЕМНИЯ

... 1. Способ приготовления органо-модифицированного материала на основе оксида кремния, заключающийся в приготовлении реакционной смеси путем смешения водной среды, содержащей от приблизительно 25 до приблизительно 100 мас.% воды, материал (S) на основе оксида кремния и одно или несколько органосилановых соединений (А), и взаимодействие данной смеси, причем одно или несколько органосилановых соединений А имеют: ! - общую формулу (R1)3-n(X)nSiR3-, где R1 представляет собой С1-С4 алкил, С2-С4 алкенил или С2-С4 алкинил, R3 представляет собой С1-С8 алкил, С2-С8 алкенил или С2-С8 алкинил, а Х представляет собой уходящую группу, n=2 или 3, или ! - общую формулу: (R4)3-n(X)nSiR6Si(R5)3-m(Y)m, где R4 и R5 независимо друг от друга представляют собой С1-С4 алкил, С2-С4 алкенил или С2-С4 алкинил, R6 представляет собой С1-С8 алкилен, С2-С8 алкенилен или С2-С8 алкинилен, а Х и Y представляют собой уходящие группы, n=2 или 3, m=2 или 3, ! материал (S) на основе оксида кремния существует в форме пористых ...

СПОСОБ ПОЛУЧЕНИЯ СОРБЕНТА НА ОСНОВЕ СШИТОГО ПОЛИМЕРА-УГЛЕРОДА

... 1. Способ получения сорбента на основе полимера-углерода, включающий смешение и отверждение:а) углеродистого сорбента,b) отверждающегося аминсодержащего полимера,включающий контактирование аминсодержащего полимера, имеющего первичные аминогруппы, с аллилгалогенидом в присутствии катализатора с образованием отверждающегося аминсодержащего полимера, содержащего концевые аллил-группы, вторичные и третичные аминогруппы,с) серного агента Sв орторомбической, моноклинической или аморфной формеd) ускорителя отверждения ие) необязательно, активатора.2. Способ по п. 1, в котором аминсодержащий полимер имеет среднечисленную молекулярную массу от примерно 1000 до примерно 10000.3. Способ по п. 1, в котором ускорителем отверждения является цинковая соль диэтилдитиокарбамата.4. Способ по п. 1, в котором серный агент вводят в избытке от количества, требуемого для отверждения отверждающегося аминсодержащего полимера в присутствии углеродистого сорбента.

PROCESS FOR EXTRACTING GALLIUM FROM INDUSTRIAL SOLUTION OF SODIUM ALUMINATE IN BAYER PROCESS

Chromatographie, die Siliziumdioxyd basierende Adsorbentien verwendet.

GEBUNDENE STATIONAERE PHASE FUER CHROMATOGRAPHIE.

TRENNUNG VON METALLEN DER PLATINGRUPPE

POROUS SYNTHETIC SORBENTS WITH A BIOCOMPATIBLE SURFACE AND THEIR PREPARATION

POROUS INORGANIC SUPPORT MATERIALS

... 1432713 Porous inorganic support materials CORNING GLASS WORKS 3 July 1974 [9 July 1973] 29456/74 Headings C1A C1M and C1N [Also in Division C3] A porous, substantially water-insoluble inorganic support material of specific surface area at least 5 m.2/g. consists of at least one metal oxide and has surface imino groups The porous material may be glass, zirconiacoated glass, alumina or titania, and the specific surface area is preferably at least 50 m.2/g. The porous material preferably has an average pore diameter of 200-1000 Š and a particle size of 20-80 mesh (U.S. Standard Sieve). The material having surface imino groups is made by reacting a porous, substantially waterinsoluble inorganic material of specific surface area at least 5 m.2/g., consisting of at least one metal oxide and having surface hydroxyl or oxide groups, with an aqueous solution of cyanogen bromide at pH 9-12. The reaction is preferably conducted at 0- 25‹ C. for at least 5 minutes, the pH ...

PREPARATION OF SELECTIVE ADSORBING PARTICLES

... 1462088 Selective absorbing carbon particles TOYO JOZO CO Ltd 18 March 1974 [19 March 1973] 11996/74 Heading C1A Selective absorbing carbon particles are prepared by forming particles of a dispersion of activated charcoal in a hydrophilic solvent solution of a polymer capable of forming a semipermeable film in a coagulating medium and then adding the dispersion dropwise into a bath of the coagulating medium to form the particles. Hydrophilic solvents may be selected from N2,N- dimethylformamide, dimethylsulfoxide, N,N- dimethylacetamide, acetone, methyl ethyl ketone, methanol, ethanol or isopropanol; as the polymer, ethyl cellulose, cellulose acetate, cellulose acetate phthalate, nitrocellulose, hydroxypropylmethyl cellulose phthalate, polyvinyl chloride, polyvinyl formal, polyvinyl butyral, polystyrenes, polyesters and polyacrylonitriles can be used; coagulating mediums may be selected from water, aqueous salt solutions, surfactant solutions, hydrophilic protective colloid solutions ...

ADSORBENT COMPOSED OF POROUS BEADS OF CHITOSAN AND ADSORPTION METHOD USING SAME

High performance anion-exchange chromatographic packing composition

An anion-exchange chromatographic packing composition has a substrate which comprises particles of from 1 to 75 micrometers diameter and having cation-exchanging sites at least on their available surfaces. The particles have a liquid coating which comprises a hydrophilic, water-soluble, film-forming resin having anion-exchanging sites which attract available cation-exchanging sites of the substrate, whereby the liquid coating is retained by electrostatic bonds on the available surfaces of the substrate particles. ...

Column for adsorption of blood proteins

A column for adsorption of blood proteins is disclosed which comprises a blood inlet and a blood outlet each with a filter, and a porous material packed between both the filters, which material has a mean pore diameter (D) of 30-3,000 angstroms with the volume occupied by pores with diameters of 0.8 D-1.2 D being at least 80% of the whole pore volume. The adsorption column can eliminate specific blood proteins by selective adsorption and is useful in the treatment of autoimmune diseases and cancer, for instance.

Rapid analysis of steroids and steroid derivatives

The subject technology is directed to a CO2-based chromatography system and method for rapid determination of the levels and/or the presence or absence of steroids or steroid derivatives in a sample.

Materials for hydrophilic interaction chromatography and processes for preparation and use thereof for analysis of glycoproteins and glycopeptides

A porous material comprising a copolymer comprising at least on hydrophilic monomer and at least a first and second poly-amide bonded phase, wherein the average pore size is greater than or equal to 200 Å or between 1 and 50Å. The porous material may comprise porous particles or a porous monolith comprising said copolymer. The hydrophilic polymer preferably comprises monomers having di or tri alkoxy silanes. The poly-amide bonded phase may comprise acrylamides, acrylates, acrylonitriles, and preferably poly(divinyl benzene-co-N-vinylcaprolactam). The material can have a median pore diameter of about 100 Å to about 1000 Å and a nitrogen content from about 0.5% to about 20%. Methods using said porous material for isolating, analysing and determining levels of a component from a mixture are disclosed, particularly via hydrophilic interaction liquid chromatography (HILIC). Methods are directed towards the separation of proteins and glycosylated proteins, due to improved pore diffusion arising ...

Reversed endcapping and bonding of HPLC phases using hydrosilanes

Materials for hydrophilic interaction chromatography and processes for preparation and use thereof for analysis of glycoproteins and glycopeptides

Conversion of normal phase silica to reverse phase silica

SEPARATION OF D-AMINOACID OXIDASE

... 1478423 Silica carrying carboxyphenyl alkylamino residues RHONE-POULENC INDUSTRIES 18 April 1975 [22 April 1974] 16119/75 Heading ClA [Also in Division C3] Enzymes are separated from protein solutions containing them by adsorption on a column of siliceous mineral carrier bearing haloalkylsilane grafts modified by replacement of the halo with residues of formula-NH-(CH 2 ) 3 -NH(CH 2 ) 2 -C 6 - H 4 -COOH. In an example a SiO 2 hydroxyl is reacted with triethyoxyiodopropylsilane in benzene and the product is further reacted with a benzene solution containing H 2 N- (CH 2 ) 3 -NH-(CH 2 ) 2 -C 6 H 4 COOC 2 H 5 before hydrodrying the resultant ester with 4N HCl.

CARRIER MEANS COATED WITH A HETERO-MACROCYCLIC COMPOUND

Arsenic remediation methods and coated adsorbent compositions therefor

Process using rare earth to remove oxyanions from aqueous streams

Process using rare earth to remove oxyanions from aqueous streams

Arsenic remediation methods and coated adsorbent compositions therefor

SURFACE-CHANGED DIVINYLBENZENHARZ WITH HÄMOKOMPATIBLER COATING

USE MONOLITHIC SORBENTIEN FOR PRÄPARATIVE CHROMATOGRAPHI SEPARATION PROCESSES

ADSORPTION COLUMN FOR THE CLEANING OF BODY FLUIDS

MEHRANALYT AFFINITÄTSSÄULE ONE TO THE ANALYSIS OF AFLATOXIN, FUMONISIN, OCHRATOXIN AND ZEARALENON

MEHRANALYT AFFINITÄTSSÄULE ONE TO THE ANALYSIS OF AFLATOXIN, OCHRATOXIN, ZEARALENON AND DEOXYNIVALENOL

SORPTIONSMITTEL FÜR ENDOTOXINE

The invention relates to a sorbent for removing endotoxins from a biological liquid, the sorbent comprising a water-insoluble, porous support and polymyxin which is immobilized on the support, said support having a neutral, hydrophobic surface and the polymyxin being immobilized on the surface of the support via hydrophobic interaction. The sorbent is especially used in extracorporeal blood purification, especially for the treatment of individuals suffering from a sepsis.

PROCEDURE FOR THE TREATMENT OF MUTAGENEN.

REACTION PRODUCT OF A GRAFTED DEXTRANOMERES AND A PHTHALOCYANINFARBSTOFFS AND ITS USE.

FIRM CARRIER FROM QUATERNISIERTER PEI SILICIC ACID FOR THE CHROMATOGRAPHY.

OPTICALLY ACTIVE ONE (METH) ACRYLIC ACID DERIVATIVES, ITS PRODUCTION, YOUR POLYMERIZATION TO OPTICAL ACTIVE ONES POLYMERS AND THEIR USE.

AT SURFACE GRAFTED SUBSTRATE, ITS PRODUCTION AND THIS CARRIER ABSTENTION ADSORBENTIEN FOR AFFINITY CHROMATOGRAPHY, AS WELL AS THEIR USE IN BIOLOGY.

HYDROPHOBE ADSORBENTIEN AND YOUR USE FOR THE ADSORPTION OF LIPOPROTEINEN

PROCEDURE AND DEVICE FOR THE RECUPERATION OF IMMUNOGLOBULINEN.

CHIRALE STATIONARY PHASES FOR THE CHROMATOGRAPHI SEPARATION FROM OPTICAL ISOMERS

SEPARATION FROM METALS OF GROUP OF PLATINUM

USE OF WITH POLYMER COATING SORPTIONSMITTELKOMPOSIT FOR THE SEPARATION, CLEANING, DEMINERALIZATION AND CONCENTRATION OF BIO POLYMERS

BORATE DISTANCE IN THE CHROMATOGRAPHY

USE OF SYNTHETIC GRANULATES OR POWDER FOR THE DISTANCE OF LIQUID ONES, GASEOUS ONES AND/OR SOLVED COMPONENTS OF A PROCESS STREAM

DEVICE FOR THE CLEANING OF PROTEINHALTIGER SOLUTIONS, PROCEDURES FOR THE PRODUCTION OF A SUBSTRATE FOR THE DEVICE AND USE OF THE DEVICE

SULFUR AND NITROGEN-CONTAINING HYDROCARBON COMPOUNDS AND PROCESS USING SAME IN RECOVERING AND CONCENTRATING DESIRED IONS FROM SOLUTIONS THEREOF

Affinity adsobents for fibrinogen

Triazine compounds and their use in forming multidimensional libraries for affinity chromatography

REMOVAL OF ARSENIC AND OTHER ANIONS USING NOVEL ADSORBENTS

AN EXTRACORPOREAL STABILISED EXPANDED BED ADSORPTION METHOD FOR THE TREATMENT OF SEPSIS

SIZE-EXCLUSION FILTERING DEVICE, METHOD FOR MAKING SAME AND RESULTING FILTERING METHOD

A material for elimination or detoxification of super antigens

Process for removing aromatic compounds from product- containing solutions

Removal of borate in chromatography

PHASE SUPPORTS FOR THE PARTITION CRHOMATOGRAPHY OF MACROMOLECULES, PRODUCTION METHOD THEREOF AND UTILIZATION THEREOF

Adsorbents for high mobility group proteins and column for purifying body fluid

Use of a composite polymer-coated sorbent for separation, purification, desalting and concentration of biopolymers

A PROCESS FOR THE SYNTHESIS OF A CHROMATOGRAPHIC PHASE

A process for the synthesis, delivery or deposition or localisation of a chromatographic phase, especially for chromatographic separation or solid phase extraction, comprises introducing a chemical moiety to a support using a supercritical fluid such as supercritical carbon dioxide.

PURIFICATION OF IMMUNOGLOBULINS

The present invention relates to a separation matrix comprised of a porous support to which ligands have been immobilised, wherein said ligands comprise at least one aliphatic sulphonamide. The nitrogen of the sulphonamide may be a secondary or tertiary amine. The invention also relates to a chromatography column that contains the described separation matrix, as well as to a method of isolating immunoglobulin-like compounds by adsorption to a separation matrix that comprises aliphatic sulphonamide ligands.

SEPARATION COLUMN FOR CHROMATOGRAPHY, MEDIUM FOR SOLID PHASE EXTRACTION AND SAMPLE INJECTION SYSTEM FOR CHROMATOGRAPHY

A separation column for chromatography or a medium for solid phase extraction, which comprises a hollow capillary and a collected body packed in the hollow capillary and serving as a stationary phase, the collected body comprising long fibers having an adsorbing ability selective towards a target solute and arranged in the axial direction of the capillary, and a sample injection system which comprises the foregoing hollow capillary incorporated into a loop of a valve or a passage connecting two valves, the valve(s) being used as an injector for the chromatography. The use of the polymeric long fibers, which have chemical structures specially designed so that they can specifically interact with a target substance (a solute or an analyte) to be analyzed, permits the selective or preferential extraction and/or concentration of the solute.

PHASE SUPPORTS FOR THE PARTITION CHROMATOGRAPHY OF MACROMOLECULES, A PROCESS FOR THEIR PREPARATION AND THEIR USE

Phase supports for the partition chromatography of macromolecules, composed of non-adsorptive base support particles which are insoluble in the phase system and have an average particle size within the range from 7 to 2000 .mu.m, the surface of which is coated with a material which is insoluble in the phase system, adheres firmly and has an affinity for one of the phases of the phase system for the partition chromatography, a process for their preparation and their use for separating, by partition chromatography, macromolecules, biopolymers, subcellular units and whole cells, in particular in an aqueous polyethylene glycol/dextran two-phase system.

ACYLATED POLYETHYLENIMINE BOUND CHROMATOGRAPHIC PACKING

ACYLATED POLYETHYLENIMINE BOUND CHROMATOGRAPHIC PACKING The acylated reaction product of silica gel or controlled pore glass and polyethyleniminopropyl trimethoxy silane suitable for use as chromatographic column packing, wherein said acyl function does not have a terminal carboxyl.

SULFONIC DERIVATIVES OF ACYLATED POLYETHYLENIMINE BONDED PHASE SILICAPRODUCTS

SULFONIC DERIVATIVES OF ACYLATED POLYETHYLENEIMINE BONDED PHASE SILICA PRODUCTS Sulfonic derivatives of N-acylated covalently bound, non-crosslinked polyethyleneimine bonded phase silicas of the formula: wherein ? is the backbone of a silica gel or glass, n is an integer such that the polyethyleneiminopropyl silane group has an average molecular weight of from about 400 to about 1800; q is an integer of zero or one; R is selected from the group consisting of hydrogen, or where x is an integer of 1 or 2 and m is an integer of zero or 1; when R is hydrogen or then R1 is where p is an integer of zero ox 1, and when R is then R1 is selected from the group consisting of hydrogen or where y is an integer of zero or 1, are especially useful as solid phases for the purification and separation of proteins having isoelectric points of below about 5.

PACKING MATERIAL FOR LIQUID CHROMATOGRAPHY

PACKING MATERIAL FOR LIQUID CHROMATOGRAPHY A packing material for liquid chromatography, comprising particles having a silicone polymer film coated on substantially the entire surface thereof, the packing material being produced by a process comprising the steps of: (a) bringing at least one silicone compound having the general formula (I): (R1HSiO)a(R2R3SiO)b(R4R5R6SiO?)c (I) wherein R1, R2, and R3 represent, independently, a hydrocarbon residue having 1 to 10 carbon atoms, which may be substituted with at least one halogen atom, R4, R5, and R6 represent, independently, hydrogen or a hydrocarbon residue having 1 to 10 carbon atoms, which may be substituted with at least one halogen atom, a is zero or an integer of 1 or more, b is zero or an integer of 1 or more, c is zero or 2, and a + b + c is 3 to 300, into contact with particles, whereby the silicone compound is polymerized on substantially the entire surface of the particles, and (b) crosslinking unreacted Si-H groups in the presence ...

SUPPORT MATRIX FOR AMINO-CONTAINING BIOLOGICALLY ACTIVE SUBSTANCES

An improved immobilized enzyme composite is prepared by subjecting a siliceous carrier to an initial treatment with alkali, then acid, then reacting the carrier with an organosilane. The organosilane may then be coupled through a covalent coupling agent with an enzyme. The alkali-acid treatment provide n exceptionally high number of hydroxyl groups per unit volume. so that the treated carrier is especially useful in the preparation of high performance immobilized enzyme compositions, particularly by multi-layering immobilization, providing a very high amount of enzyme activity per unit volume. Multi-layering is accomplished by successive steps of bonding a difunctional covalent coupling agent to a previously immobilized enzyme layer, then bonding an additional layer of enzyme to the coupling agent. This may be repeated to apply as many layers as desired.

COMPOSITION FOR CHROMATOGRAPHY

AFFINITY ADSORBENTS FOR FACTOR VIII AND VON WILLEBRAND'S FACTOR

For the separation, removal, isolation, purification, characterisation, identification or quantification of Factor VIII, von Willebrand's Factor or a protein that is a analogue of either, an affinity adsorbent is used that is a compound of formula (II) wherein one X is N and the other is N, C-C1 or C-CN; A is a support matrix, optionally linked to the triazine ring by a spacer; Y is O, S or NR2; Z is O, S or N-R3; R2 and R3 are each H, C1-6 alkyl, C1-6 hydroxyalkyl, benzyl or .beta.-phenylethyl; B and W are each an optionally substituted hydrocarbon linkage containing from 1 to 10 carbon atoms; D is H, OH or a primary amino, secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidino or amidino group; or B-D is -CHCOOH-(CH2)3-4-NH2; and R7 is a group bearing a positive charge at neutral pH.

BLOOD PURIFICATION DEVICE

SURFACE MODIFIED DIVINYLBENZENE RESIN HAVING A HEMOCOMPATIBLE COATING

... ▓▓▓A polymeric resin is disclosed in the form of beads or particles having a ▓coating thereon which renders the resin blood compatible. The resin comprises ▓divinylbenzene monomer which has a porosity, pore size, and surface area ▓suitable for absorption of unhealthy components of blood, such as .beta.-2-▓microglobulin.▓ ...

APPARATUS AND METHODS FOR CLEANING AND OXYGEN-ENRICHING AIR

A portable breathing apparatus for oxygen enrichment of breathable air comprises: an adsorption vessel; an air compressor for pumping air into the adsorption vessel; a valve for purging pressure from the adsorption vessel; an adsorbent disposed within the adsorption vessel adsorbing a non-oxygen constituent of air when the vessel is pressurized, thereby producing oxygen-enriched air, and desorbing the non-oxygen constituent when the pressure is purged.

SURFACE-GRAFTED PARTICULATE SUPPORT, PROCESS FOR ITS PREPARATION AND ADSORBANTS FOR AFFINITY CHROMATOGRAPHY INCORPORATING SUCH SUPPORT, AND THEIR USE, PARTICULARLY IN BIOLOGY

NOVEL CROSSLINKED POLYMERIC SUBSTRATES METHODS OF PREPARATION AND END USE APPLICATIONS OF THE SUBSTRATES

... ²A composition of matter wherein the composition comprises a siliceous ²substrate ²having silanols on the surface and a polymer selected from the group ²consisting ²essentially of a water soluble polymer, a water soluble copolymer, an alcohol ²soluble ²polymer, an alcohol soluble copolymer, and combinations of such polymers, ²wherein the ²polymer is chemically bonded to the siliceous substrate by a silane linking ²material ²having the general formula² O3/2SiQY²that is derived from an alkoxy-functional silane having the general formula²(RO)3SiQX²and processes for preparing the crosslinked polymer that is chemically bonded ²to the ²surface of the siliceous substrate.² ...

Passivated and Stabilized Porous Supports and Methods for the Preparation and Use of Same

This invention relates generally to modified porous solid supports and processes for the preparation and use of same. In particular, passivated porous mineral oxide, polymeric, or polymer-coated mineral oxide supports are disclosed which are characterized by a reversible high sorptive capacity substantially unaccompanied by non-specific adsorption of or interaction with biomolecules. Passivation is achieved by use of a passivation mixture comprising a main monomer, a passivating monomer and a crosslinking agent, which mixture upon polymerization results in the substantial elimination of the undesirable non-specific interaction with biomolecules.

REAGENTS

Improved affinity purification media are provided by the use of small specific binding agents, especially Fv antibody fragments or single domain antibody fragments, immobilised on porous carriers having pore sizes in the range 30-1000 angstroms, preferably 30-300 angstroms. Silica is a preferred carrier. The small fragments are able to penetrate the pores and maximise the effective surface area of the carrier, and the microporous silica is sufficiently robust to be used at high pressure, so enabling the speed and/or throughput of a purification procedure to be increased.

POLYMER BEAD CONTAINING IMMOBILIZED METAL EXTRACTANT

Toxic metal contaminants dissolved in dilute aqueous solutions such as waste waters are removed by contact with water insoluble polymeric beads having an internal pore structure containing immobilized extractant material capable of sorbing the metal contaminants. The beads are prepared by forming a solution of a polymeric material in an organic solvent, blending the extractant into the solution and injection the solution through a nozzle into water to form beads. The polymeric material is preferably polysulfone or cellulose acetate, and the extractant may be yeast, algae, penicillium mold, xanthan gum, guar gum, alginate, common duckweed (Lemna sp.) or a chemical compound. A metal of value can be separated from the extractant by using dilute mineral acids or other dilute solutions to solubilize the metal.

ABSORBENT FOR THE REMOVAL OF BIOMACROMOLECULES SUCH AS LDL AND ENDOTOXINS FROM WHOLE BLOOD IN EXTRACORPOREAL CIRCUITS

A material for the elimination of biomacromolecules, in particular LDL and ignotoxins from a whole blood circuit, comprising an absorbent, comprising a porous carrier material of a homo-, co-, or terpolymerizate of acrylic acid and/or methacrylic acid with a particle range of between 50 and 250 mmol and an exclusion level of at least 5 x 10 5 daltons, as well as organic ligands which are covalently bound to the carrier material via a spacer, wherein the carrier material has a spherical shape and suitably, the spacer contains no double bonds.

CHEMICAL PRODUCTS

A separation medium for use in protein separation comprising a water-insoluble m atrix carrying a plurality of polyamine groupings, said polyamine groupings having at least three basic nitrogen atoms. said basic nitrogen atoms being separated from each other by a chain of at least two intervening carbon atoms, there being a to tal of 5 such intervening carbon atoms when there is a total of three nitrogen atoms in each polyamine group, which may be used fo r at least partially purifying factor VIII.

TREATING RHODIUM, IRIDIUM AND RUTHENIUM SOLUTIONS

... 2103144 9221419 PCTABS00017 A method for the removal, separation, and concentration of Rh, Ir, and/or Ru from a source solution which may contain larger concentrations of other ions including H+ comprises bringing the source solution into contact with a compound comprising a polyalkylene-polyamine-containing ligand covalently bonded through an organic spacer silicon grouping to a solid inorganic support. The ligand portion(s) of the compound has affinity for complexed anionic species of Rh, Ir, and/or Ru. The Rh and/or Ru are first selectively removed from the compound through contact with a much smaller volume of a first receiving solution. The Ir is then removed from the compound through contact with a much smaller volume of a second receiving solution having a greater affinity for the Ir than the liquid portion of the compound or having a greater affinity for the ligand portion of the compound than the Ir species. The process is useful in the recovery and refining of the valuable Rh ...

REMOVAL OF BORATE IN CHROMATOGRAPHY

Borate-binding compositions are provided comprising polymers containing covalently attached borate-binding carbohydrates. Methods of making and using the compositions are also provided.

IMMOBILISED BRANCHED POLYALKYLENEIMINES

A solid phase ligand comprising branched polyalkyleneimine covalently bound to an inorganic support by a linking group.

Procédé pour extraire des substances organiques de solutions les contenant.

Procédé d'extraction de composés organiques hors de leur solution

Füllkörper, der insbesondere für Chromatographiekolonnen geeignet ist

CHROMATOGRAPHISCHES SORPTIONSMITTEL UND VERFAHREN ZUR HERSTELLUNG DESSELBEN.

PROCEDE D'OBTENTION DES CORPS DE GEL DE SILICE A PROPRIETES DE SURFACE MODIFIEES.

Flüssigkeitsbrücke

Zur Trennung von Stoffgemischen einsetzbares Adsorptionsmittel und seine Anwendung

[...] A [...][...].

PROCEDURE FOR THE PRODUCTION OF SPECIFIC SORBENTIEN.

PROCESS FOR THE PREPARATION OF POROUS MATERIAL.

MATERIAL FOR THE DISTANCE OF IMMUNE COMPLEXES FROM THE BLOOD OR FROM PLASMA.

PROCEDURE AND DEVICE FOR THE INTERMITTENT REGENERATION OF AN ADSORPTION COLUMN.

PROCEDURE FOR THE IMMOBILIZATION AND CLEANING OF PROTEINS.

BIOCHEMICAL PROCESS, GLASS MICROSPHERES AND BIOREACTOR FOR SEPARATING MATTER FROM A FLUID MEDIUM.

Drug-adsorbing material and medical device comprising same

A drug-adsorbing material capable of efficiently adsorbing and eliminating drugs (such as carcinostatic agents) from blood with a small amount without causing foreign body recognition reaction, such as blood coagulation, and a medical device provided with said drug-adsorbing material. The drug-adsorbing material is based on polymeric microparticles which swell upon adsorption of plasma components at pH value of 7 or above and keep their shape after swelling. The drug-adsorbing material is incorporated into a drug-administrating device for drug adsorption.

Activated solid support and method

Disclosed is a method for activating a solid support material with epoxy groups and for immobilising ligands thereon, utilising phase transfer catalytic conditions. The method permits the introduction of epoxy groups and specific nucleophilic ligands on the support material with a high level of substitution. Furthermore, the invention provides a general method for immobilising a ligand for use in a wide variety of chromatographic separation procedures such as ion exchange chromatography, hydrophobic interaction chromatography (HIC), reverse phase chromatography (RPC), or affinity chromatography.

Crosslinked Polymer-Carbon Sorbent for Removal of Heavy Metals, Toxic Materials and Carbon Dioxide

A polymer-carbon sorbent for removing carbon dioxide, heavy metals and toxic materials from a flue gas from a combustion process, such as coal-fired power plants, is described. The sorbent comprises a carbonaceous sorbent material and a cured amine-containing polymer, and sulfur. The polymer-carbon sorbents are formed by curing a curable amine-containing polymer in the presence of the carbonaceous sorbent material, sulfur, a cure accelerator and, optionally, a cure activator. A convenient carbonaceous sorbent material is an activated carbon, and a convenient curable amine-containing polymer is an allyl-containing poly(ethyleneimine), having a number average molecular weight between about 1,000 and about 10,000. The polymer-carbon sorbents may contain sulfur in excess of an amount needed to cure the curable amine-containing polymer. Such polymer-carbon sorbents are shown to capture more mercury, in both elemental an ionic forms, compared to activated carbon and adsorb carbon dioxide.

High purity chromatographic materials comprising an ionizable modifier

The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are high purity chromatographic materials comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifier.

CALCIUM ALGINATE ADSORBENTS

A method of treating a liquid for removal of organic acid anions which comprises contacting a liquid containing organic acid anions with an adsorbent comprising calcium alginate-kaolinite or calcium alginate-quartz and a method of treating a liquid for removal of organic acid anions, heavy metal ions and thermally degraded organic products which comprises contacting a liquid containing organic acid anions, heavy metal ions and thermally degraded organic products with an adsorbent comprising calcium alginate-activated carbon are described. 1. A method of treating a liquid for removal of organic acid anions which comprises contacting a liquid containing organic acid anions with an adsorbent comprising calcium alginate-kaolinite (CAK) or calcium alginate-quartz (CAQ).2. The method of wherein the adsorbent is prepared by a process comprising adding drop-wise a mixed solution of alginate and kaolinite or quartz to a calcium chloride solution claim 1 , thereby cross linking alginate with calcium ions and finally get the adsorbent.3. The method of or which comprises passing of said liquid containing organic acid anions through a column containing said adsorbent in gel form.4. A method of treating a liquid for removal of organic acid anions claim 1 , heavy metal ions and thermally degraded organic products which comprises contacting a liquid containing organic acid anions claim 1 , heavy metal ions and thermally degraded organic products with an adsorbent comprising calcium alginate-activated carbon (CAC).5. The method of wherein the adsorbent is prepared by a process comprising adding drop-wise a mixed solution of alginate and activated carbon powder to calcium chloride solution to form a carbon impregnated CAC adsorbent.6. The method of or which comprises passing of said liquid containing organic acid anions claim 4 , heavy metal ions and thermally degraded organic products through a column containing said adsorbent in gel form.7. The method of any preceding claim wherein ...

CHROMATOGRAPHIC MATERIAL HAVING IMPROVED PH STABILITY, METHOD FOR PREPARATION THEREOF AND USES THEREOF

A chromatographic material including a substrate having a surface and having a polymeric layer covalently bound to the surface; the polymeric layer comprising polymer molecules covalently attached to the surface of the substrate, each polymer molecule being attached to the surface via multiple siloxane bonds and each polymer molecule being connected to one or more functionalizing compounds that each comprise a functional group, wherein the polymeric layer is formed by covalently attaching polymer molecules to the surface of the substrate via multiple siloxane bonds, each polymer molecule containing multiple first reactive groups, and reacting the first reactive groups of the attached polymer molecules with at least one functionalizing compound that comprises a second reactive group that is reactive with the first reactive groups and that further comprises a functional group. Preferred conditions of reacting the polymer with the substrate include elevated temperature and reduced pressure. 1. A chromatographic material comprising:a substrate having a surface and the substrate having a polymeric layer covalently bound to the surface;the polymeric layer comprising polymer molecules covalently attached to the surface of the substrate, each polymer molecule being attached to the surface via multiple siloxane bonds and each polymer molecule being connected to one or more functionalizing compounds that each comprise a functional group.2. The chromatographic material according to claim 1 , wherein the polymeric layer is formed by covalently attaching polymer molecules to the surface of the substrate via multiple siloxane bonds claim 1 , each polymer molecule containing multiple first reactive groups claim 1 , and reacting the first reactive groups of the attached polymer molecules with at least one functionalizing compound that comprises a second reactive group that is reactive with the first reactive groups and that further comprises a functional group.3. The ...

Chlorine neutralizer, throw-in type chlorine neutralizer containing the same, chlorine neutralizing apparatus, and chlorine neutralizing method

A chlorine neutralizer which can be used and manufactured in a simplified manner, a throw-in type chlorine neutralizer containing the same, a chlorine neutralizing apparatus, and a chlorine neutralizing method are provided. A chlorine neutralizer which neutralizes a chlorine-based component contains at least one selected from a vinyl alcohol based polymer and a polyamide resin, and the vinyl alcohol based polymer contains at least vinyl alcohol in a repeating structural unit.

METHOD FOR SYNTHESISING AMBROXIDE FROM AGERATINA JOCOTEPECANA

The present invention is related to a process for obtaining the (−)-13,14,15,16-tetranor-8a,12-labdanediol compound from the plant, the process comprises the steps of a) obtaining an organic concentrated extract from the shoot system; b) subjecting the organic concentrated extract to column chromatography in order to elute a fraction with the (−)-13,14,15,16-tetranor-8a,12-labdanediol compound; c) separating the eluted fractions comprising the (−)-13,14,15,16-tetranor-8a,12-labdanediol compound; and d) evaporating the organic solvent to yield the (−)-13,14,15,16-tetranor-8a,12-labdanediol compound in a solid form. 1Ageratina jocotepecanaAgeratina jocotepecana. A process for obtaining the (−)-13 ,14 ,15 ,16-tetranor-8a ,12-labdanediol compound from the plant , wherein the process comprises the steps of: a) obtaining an organic concentrated extract from the shoot system; b) subjecting the organic concentrated extract to column chromatography to elute a fraction with the (−)-13 ,14 ,15 ,16-tetranor-8a ,12-labdanediol compound; c) separating the eluted fractions comprising the (−)-13 ,14 ,15 ,16-tetranor-8a ,12-labdanediol compound; and d) evaporating the organic solvent to yield the (−)-13 ,14 ,15 ,16-tetranor-8a ,12-labdanediol compound in a solid form.2Ageratina jocotepecanaAgeratina jocotepecanaAgeratina jocotepecanaAgeratina jocotepecanaAgeratina jocotepecanaAgeratina jocotepecana. The process according to claim 1 , wherein the organic concentrated extract from the shoot system is obtained by a process comprising the following steps: a) drying the plant shoot system claim 1 , wherein the shoot system comprises the aerial parts of the plant claim 1 , such as flowers claim 1 , leaves and/or stems; b) macerating or refluxing the plant shoot system in an organic solvent for a period of time from 6 to 72 hours; c) filtering out the macerated or refluxed extract of step (b) to obtain an organic extract; and d) evaporating the solvent from the organic extract.3. The ...

POROUS COMPOSITE PARTICULATE MATERIALS, METHODS OF MAKING AND USING SAME, AND RELATED APPARATUSES

In an embodiment, a porous composite particulate material includes a plurality of composite particles. Each composite particle includes an acid-base-resistant core particle at least partially surrounded by one or more layers of acid-base-resistant shell particles. The shell particles are adhered to the core particle by a polymeric layer. The shell particles and/or core particles may be made from an acid-base-resistant material that is stable in harsh chemical conditions. For example, the shell particles may be made from diamond, graphitic carbon, silicon carbide, boron nitride, tungsten carbide, niobium carbide, zirconia, noble metals, combinations of the foregoing, or other acid-base-resistant materials and the core particle may include at least one exterior layer of non-diamond carbon. The porous composite particulate materials disclosed herein and related methods and devices may be used in separation technologies, including, but not limited to, chromatography and solid phase extraction. 1. A method for manufacturing a porous composite particulate material , the method comprising:providing a plurality of acid-base-resistant core particles, wherein a number of the plurality of acid-base-resistant core particles includes at least one exterior layer of non-diamond carbon;providing a plurality of acid-base-resistant shell particles;coating at least a portion of the plurality of acid-base-resistant core particles, at least a portion of the plurality of acid-base-resistant shell particles, or combinations thereof with polymer material;adhering a portion of the plurality of acid-base-resistant shell particles to each of the plurality of acid-base-resistant core particles with the polymer material to form a plurality of composite particles; andcross-linking the polymeric material.3. The method of claim 1 , wherein each of the number of the plurality of acid-base-resistant core particles includes about 70 volume % to about 90 volume % of the non-diamond carbon.4. The ...

POROUS COMPOSITE PARTICULATE MATERIALS, METHODS OF MAKING AND USING SAME, AND RELATED APPARATUSES

In an embodiment, a porous composite particulate material includes a plurality of composite particles. Each composite particle includes an acid-base-resistant core particle at least partially surrounded by one or more layers of acid-base-resistant shell particles. The shell particles are adhered to the core particle by a polymeric layer. The shell particles and/or core particles may be made from an acid-base-resistant material that is stable in harsh chemical conditions. For example, the shell particles and/or core particles may be made from diamond, graphitic carbon, silicon carbide, boron nitride, tungsten carbide, niobium carbide, zirconia, noble metals, acid-base stable highly cross-linked polymers, acid-base stable at least partially cross-linked polymers, titania, alumina, thoria combinations of the foregoing, or other acid-base-resistant materials. The porous composite particulate materials disclosed herein and related methods and devices may be used in separation technologies, including, but not limited to, chromatography and solid phase extraction. 1. A porous composite particulate material , comprising:a plurality of composite particles, at least some the plurality of composite particles including:an acid-base-resistant core particle;a plurality of acid-base-resistant shell particles at least partially surrounding the acid-base-resistant core particle, wherein the plurality of acid-base-resistant shell particles include at least one of diamond or graphitic carbon; andat least one polymer that is acid-base-resistant and exhibits about 1% to about 99% cross-linking, the plurality of acid-base-resistant shell particles bonded together by the at least one polymer.2. The porous composite particulate material of claim 1 , wherein each of the acid-base-resistant core particles of the at least some of the plurality of composite particles includes diamond or graphic carbon.3. The porous composite particulate material of claim 1 , wherein each of the acid-base- ...

NOVEL AFFINITY CHROMATOGRAPHY MEDIA FOR REMOVAL OF ANTI-A AND/OR ANTI-B ANTIBODIES

Embodiments described herein relate to novel chromatography media for removing anti-A and/or anti-B antibodies from a sample, as well as methods of using the same. The media described herein have several advantages over previously described media including, acid and alkaline stability. 1. A method of removing anti-A antibodies from a sample , the method comprising the steps of:(a) providing a sample comprising an amount of anti-A antibodies;(b) incubating the sample with a media comprising a solid support with a blood group A antigen ligand attached thereto, wherein the ligand is attached to the solid support at a ligand loading of at least 0.8 mg/ml of solid support, and wherein the media is stable under acid and/or alkaline conditions and wherein the solid support comprises a polymer selected from the group consisting of polyvinylether, polyvinylalcohol, polymethacrylate, polyacrylate, polystyrene, polyacrylamide, polymethacrylamide and polycarbonate and the blood group A antigen ligands are attached via pAA tentacle chemistry to a solid support, for the media to bind anti-A antibodies;(c) recovering portion of the sample which is not bound to the media; and(d) measuring amount of anti-A antibodies in the portion of the sample in (c), wherein the amount of anti-A antibodies in (d) is at least 80% less than the amount of anti-A antibodies in the sample in (a).2. A method of removing anti-B antibodies from a sample , the method comprising the steps of:(a) providing a sample comprising an amount of anti-B antibodies;(b) incubating the sample with a media for removing anti-B antibodies from a sample, the media comprising a solid support with a blood group B antigen ligand attached thereto, wherein the ligand is attached to the solid support at a ligand loading of at least 0.8 mg/ml of solid support, and wherein the media is stable under acid and/or alkaline conditions and wherein the solid support comprises a polymer selected from the group consisting of ...

Metal removal agent and metal removal method for removing metal impurities in solution

A metal adsorption agent including a chelating agent (A) and a chelating agent (B), wherein the chelating agent (A) is a metal adsorption agent containing a carrier having a glucamine-type functional group, and the chelating agent (B) is a metal adsorption agent containing a carrier having a thiol group, a thiourea group, an amino group, a triazabicyclodecene-inducing group, a thiouronium group, an imidazole group, a sulfonate group, a hydroxy group, an aminoacetate group, an amidoxime group, an aminophosphate group, or any combination of these groups. The carrier of each of the chelating agent (A) and the chelating agent (B) may be silica, a silica component-containing substance, polystyrene, or crosslinked porous polystyrene. The solution may contain water or an organic solvent.

SILICA-BASED PARTICLE WITH HYDROXY-TERMINATED PEG BONDING AND METHOXY-TERMINATED PEG SURFACE MODIFICATION

The present disclosure is directed to stationary phase materials for performing size exclusion chromatography. Embodiments of the present disclosure feature hydroxy-terminated polyethylene glycol surface modified silica particle stationary phase materials, which are optionally also methoxy-terminated polyethylene glycol surface modified. 1. A stationary phase material comprising porous silica particles having a surface , at least some substantial portion thereof modified with a hydroxy-terminated polyethylene glycol , and wherein at least a portion of the surface is modified with a methoxy-terminated polyethylene glycol.2. (canceled)3. The stationary phase material of claim 1 , wherein the porous silica particles have a diameter with a mean size distribution from about 1 to about 50 μm.4. The stationary phase material of claim 1 , wherein the porous silica particles have a diameter with a mean size distribution from about 1 to about 20 μm.5. The stationary phase material of claim 1 , wherein the porous silica particles have a diameter with a mean size distribution from about 1.5 to about 5 μm.6. The stationary phase material of claim 1 , wherein the porous silica particles have an average pore size from about 40 to about 3000 Å7. The stationary phase material of claim 1 , wherein the porous silica particles have an average pore size from about from about 1000 to about 3000 Å claim 1 , or from about 1000 to about 2000 Å.9. The stationary phase material of claim 8 , wherein m is 2 or 3.10. The stationary phase material of claim 8 , wherein n is from about 5 to about 15 claim 8 , or from about 8 to about 12.11. The stationary phase material of claim 8 , wherein m is 3 and n is from about 8 to about 12.12. The stationary phase material of claim 1 , wherein the hydroxy-terminated polyethylene glycol is present on the surface of the porous silica particles at a density from about 0.5 to about 15 μmol/m.13. The stationary phase material of claim 12 , wherein the hydroxy- ...

PACKING MATERIAL FOR LIQUID CHROMATOGRAPHY AND COLUMN FOR LIQUID CHROMATOGRAPHY

A packing material for liquid chromatography, including particles of a copolymer having a monomer unit derived from a (meth)acrylic acid ester and a monomer unit derived from divinylbenzene, wherein a ratio between the monomer unit derived from a (meth)acrylic acid ester and the monomer unit derived from divinylbenzene is 70 mass % to 90 mass %:30 mass % to 10 mass %, wherein the particles each have a sulfo group bonded to a surface thereof and a structure in which the sulfo group is bonded includes a structure represented by the formula (1): 2. The packing material for liquid chromatography according to claim 1 , wherein the (meth)acrylic acid ester includes glycidyl methacrylate.3. A method of producing the packing material of claim 1 , including the steps of: copolymerizing a monomer mixture containing a (meth)acrylic acid ester and divinylbenzene through suspension polymerization to obtain copolymer particles; and causing the copolymer particles and a sulfonating agent to react with each other in a solvent containing a secondary alcohol in the presence of a base.4. The method of producing the packing material according to claim 3 , wherein the step of causing the copolymer particles and a sulfonating agent to react with each other is performed after the step of obtaining the copolymer particles without subjecting the obtained particles to another chemical reaction.5. The method of producing the packing material according to claim 3 , wherein the (meth)acrylic acid ester is glycidyl methacrylate claim 3 , the sulfonating agent is propanesultone claim 3 , and the secondary alcohol is 2-propanol.6. A column for liquid chromatography for analysis of glycated hemoglobin claim 1 , which is packed with the packing material for liquid chromatography of .7. A method of analyzing glycated hemoglobin claim 1 , including using a column packed with the packing material for liquid chromatography of . The present invention relates to a packing material for liquid ...

POLYMER FOR SEPARATION OF ANALYTES AND METHODS FOR PREPARATION AND USE OF SAME

A polymer for liquid chromatography or solid phase extraction is provided. The polymer is prepared by polymerizing styrene and divinylbenzene to form a styrene-divinylbenzene copolymer; soaking the styrene-divinylbenzene copolymer in a swelling agent to form nano-scale micropores; and soaking the microporous styrene-divinylbenzene copolymer in methanol. When packed in a chromatographic column, the polymer can be used to produce produce natural health or medicinal products from species, for example, industrial hemp. 1. A method for making a polymer for use in liquid chromatography or solid phase extraction , the method comprising:polymerizing styrene and divinylbenzene to form a styrene-divinylbenzene copolymer;soaking the styrene-divinylbenzene copolymer in a swelling agent to form nano-scale micropores; andsoaking the microporous styrene-divinylbenzene copolymer in methanol.2. The method according to claim 1 , wherein polymerizing styrene and divinylbenzene comprises:adding the styrene, the divinylbenzene, a polymerization initiator, and a pore-forming agent to an organic medium to form a mixture; andheating the mixture to initiate a polymerization reaction and to form, by the polymerization reaction, the styrene-divinylbenzene copolymer.3. The method according to claim 1 , wherein the molar ratio of the styrene to the divinylbenzene is in a range of 0.8:1 to 1.2:1.4. The method according to claim 2 , wherein the polymerization initiator comprises one or more of azobisisobutyronitrile and benzoyl peroxide.5. The method according to claim 2 , wherein a number of moles of the polymerization initiator used is 1 to 2% of a number of moles of the styrene.6. The method according to claim 2 , wherein the pore-forming agent comprises polyethylene glycol.7. The method according to claim 2 , wherein the organic medium comprises a mixture of polyethylene glycol and liquid paraffin.8. The method according to claim 7 , wherein the volume ratio of polyethylene glycol and liquid ...

PROCESS FOR PREPARING A COPOLYMER POLYOL

A process for preparing a copolymer polyol containing a reduced content of residual monomers and volatiles including the steps of: (a) providing at least one copolymer polyol containing a first initial content of residual monomers and volatiles; (b) providing at least one molecular sieve adsorbent; (c) contacting the at least one copolymer polyol with the at least one molecular sieve adsorbent for a period of time and at a temperature sufficient for the at least one molecular sieve adsorbent to adsorb at least a portion of the first initial content of residual monomers and volatiles present in the at least one copolymer polyol to reduce the first initial content of residual monomers and volatiles of the at least one copolymer polyol to form at least one copolymer polyol containing a second reduced content of residual monomers and volatiles; and (d) separating the at least one molecular sieve adsorbent containing a portion of the first initial content residual monomers and volatiles from the at least one copolymer polyol to form at least one copolymer polyol containing a second reduced content of residual monomers and volatiles. 1. A process for preparing a copolymer polyol containing a reduced content of residual monomers and volatiles comprising the steps of:(a) providing at least one copolymer polyol containing a first initial content of residual monomers and volatiles;(b) providing at least one molecular sieve adsorbent;(c) contacting the at least one copolymer polyol with the at least one molecular sieve adsorbent for a period of time and at a temperature sufficient for the at least one molecular sieve adsorbent to adsorb at least a portion of the first initial content of residual monomers and volatiles present in the at least one copolymer polyol to reduce the first initial content of residual monomers and volatiles of the at least one copolymer polyol to form at least one copolymer polyol containing a second reduced content of residual monomers and volatiles; ...

HIGH PURITY CHROMATOGRAPHIC MATERIALS COMPRISING AN IONIZABLE MODIFIER

The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are high purity chromatographic materials comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifier. 117-. (canceled)19. The high purity chromatographic material of claim 18 , wherein the ratio of the hydrophobic surface group:ionizable modifier is from about 2.5:1 to about 12:1.20. The high purity chromatographic material of claim 18 , wherein m is 2 or 3.21. The high purity chromatographic material of claim 18 , wherein the ionizable modifying reagent is 2-(2-(trichlorosilyl)ethyl)pyridine claim 18 , 2-(2-(trimethoxy)ethyl)pyridine claim 18 , 2-(2-(triethoxy)ethyl)pyridine claim 18 , 2-(4-pyridylethyl)triethoxysilane claim 18 , 2-(4-pyridylethyl)trimethoxysilane claim 18 , 2-(4-pyridylethyl)trichlorosilane.22. The high purity chromatographic material of claim 18 , further comprising a chromatographic core material.23. The high purity chromatographic material of claim 22 , wherein the chromatographic core material is a silica material or a hybrid inorganic/organic material.24. The high purity chromatographic material of claim 23 , wherein the chromatographic core material is a superficially porous material.25. The high purity chromatographic material of claim 18 , wherein the hydrophobic surface group is a C4 to C30 bonded phase claim 18 , an aromatic claim 18 , a phenylalkyl claim 18 , a fluoro-aromatic claim 18 , a phenylhexyl claim 18 , a pentafluorophenylalkyl claim 18 , or a chiral bonded phase26. A method for preparing a high purity chromatographic material according to comprising the steps of:reacting a ...

ADSORBENT, HEAVY METAL REMOVING AGENT, MOLDED BODY USING SAME, AND WATER PURIFIER

An embodiment of the present invention relates to an adsorbent which contains a fine particle compound containing an aluminosilicate compound and activated carbon particles, wherein the fine particle compound containing an aluminosilicate compound has a specific surface area of 300 m/g or more and an average particle size of 10 to 200 μm and includes particles having a particle size of 10 μm or less in volume particle size distribution at 10 volume % or less, and the activated carbon particles have a mode diameter of 0.06 to 0.6 mm. 1: An adsorbent comprising:a fine particle compound (A) comprising an aluminosilicate compound; andactivated carbon particles;wherein:{'sup': '2', 'the fine particle compound (A) has a specific surface area of 300 m/g or more and an average particle size D50 of 3 to 200 μm;'}the fine particle compound (A) comprises particles having a particle size of 10 μm or less in a volume particle size distribution at 10 volume % or less; andthe activated carbon particles have a mode diameter of 0.06 to 0.6 mm.2: The adsorbent according to claim 1 , wherein a ratio of silicon to aluminum as oxides (SiO/AlO) in the aluminosilicate compound is 3 or less.3: The adsorbent according to claim 1 , wherein the fine particle compound (A) is resent in the adsorbent in an amount of 1 to 50 mass %.4: An adsorbent comprising:a fine particle compound (B) comprising an aluminosilicate compound;a plastic powder; andactivated carbon;wherein:the fine particle compound (B) and the plastic powder form composite aggregate particles; andthe composite aggregate particles comprise particles having a particle size of 40 μm or less in a volume particle size distribution at 15 volume % or less.5: The adsorbent according to claim 4 , wherein:{'sup': '2', 'the fine particle compound (B) has a specific surface area of 300 m/g or more and an average particle size D50 of 3 to 200 μm; and'}the fine particle compound (B) comprises particles having a particle size of 10 μm or less in ...

Separations with organic molecular solids

A host material may be used for the separation of elements or compounds, wherein the host material is an organic molecular solid with suitable cavities for accommodating a guest material to be separated, and with interconnections between the cavities to allow the guest material to diffuse through the host material, and wherein said interconnections are closed for a proportion of the time or have a static pore limiting diameter which is smaller than the static dimension of the guest material. Applications include separations of rare gases, chiral molecules, and alkanes. One class of suitable host materials may be made by imine condensation.

NOVEL CROSSLINKED POLYMERIC SUBSTRATES METHODS OF PREPARATION AND END USE APPLICATIONS OF THE SUBSTRATES

A composition of matter wherein the composition comprises a siliceous substrate having silanols on the surface and a polymer selected from the group consisting essentially of a water soluble polymer, a water soluble copolymer, an alcohol soluble polymer, an alcohol soluble copolymer, and combinations of such polymers, wherein the polymer is chemically bonded to the siliceous substrate by a silane linking material having the general formula 133.-. (canceled)34. A process for preparing a crosslinked polymer that is chemically bonded to the surface of a siliceous substrate , said process consisting essentially of:(I) heating a predetermined amount of alcohol in a reaction vessel with stirring, wherein the alcohol has from 1 to 9 carbon atoms;(II) adding a predetermined amount of a hydrolysis catalyst selected from organic acids having from 1 to 7 carbon atoms:(III) adding a predetermined amount of a silanol condensation catalyst;(IV) adding a predetermined amount of siliceous substrate containing reactive silanols; [{'br': None, 'sub': '3', '(RO)SiQX'}, 'wherein R is a hydrocarbon group having from 1 to 6 carbon atoms, Q is a hydrocarbon group having from 0 to 6 carbon atoms, X is a functional group selected from the group consisting of epoxy, halogen, methacrylate, vinyl, amine, allyl, phosphonate, styrlamine, and sulfide;, '(V) adding a predetermined amount of silane coupling agent, said silane being an alkoxy-functional silane having the general formula'} (i) a water soluble polymer,', '(ii) a water soluble copolymer,', '(iii) an alcohol soluble polymer,', '(iv) an alcohol soluble copolymer, and', '(v) combinations of (i) to (iv),, '(VI) adding a predetermined amount of polymer, said polymer being selected from the group consisting of'}(VII) stirring the combination of (I) to (VI) for a period of time of 12 hours or less at a temperature of 75° C. or less; wherein the ratio of polymer to siliceous substrate is in the range of P:S wherein P is 0.1 to 50 and S is 99.9 ...

SELECTIVE ADSORPTION OF HALOCARBON IMPURITIES CONTAINING CL, BR AND I IN FLUOROCARBONS OR HYDROFLUOROCARBONS USING ADSORBENT SUPPORTED METAL OXIDE

Methods for purification of a fluorocarbon or hydrofluorocarbon containing at least one undesired halocarbon impurities comprise flowing the fluorocarbon or hydrofluorocarbon through at least one adsorbent beds to selectively adsorb the at least one undesired halocarbon impurities through physical adsorption and/or chemical adsorption, wherein the at least one adsorbent beds contain a metal oxide supported on an adsorbent in an inert atmosphere. 1. A process for purification of a fluorocarbon or hydrofluorocarbon containing at least one undesired halocarbon impurities , comprising:flowing the fluorocarbon or hydrofluorocarbon through at least one adsorbent beds to selectively adsorb the at least one undesired halocarbon impurities through physical adsorption and/or chemical adsorption, wherein the at least one adsorbent beds contain a metal oxide supported on an adsorbent in an inert atmosphere.2. The process of claim 1 , further comprising:distilling an outlet stream of the at least one adsorption beds to obtain a purified fluorocarbon or hydrofluorocarbon.3. The process of claim 1 , wherein the at least one undesired halocarbon impurities are Cl-containing claim 1 , Br-containing claim 1 , I-containing claim 1 , or combinations thereof halocarbons.4. The process of claim 3 , wherein the at least one undesired halocarbon impurities are chlorofluorocarbons (CFC) and/or hydrochlorofluorocarbons (HCFC).5. The process of claim 1 , wherein the adsorbent is silica claim 1 , alumina or molecular sieves.6. The process of claim 1 , wherein the metal oxide is CuO or MgO.7. The process of claim 1 , wherein the metal oxide is CuO supported by alumina.8. The process of claim 1 , wherein a flow rate of the fluorocarbon or hydrofluorocarbon into the adsorption bed in vapor phase ranges from 0.5 slm to 500 l/min.9. The process of claim 1 , wherein a temperature of the adsorption bed ranges from −50° C. to 150° C.10. The process of claim 1 , wherein a concentration of impurities in ...

CANISTER

A canister that adsorbs and desorbs fuel vapor generated in a fuel tank of a vehicle includes a housing and at least one expansion inhibitor. The housing is in a form of a cylinder configured to be filled with activated carbon. The housing includes a filled portion which is an area in the housing filled with the activated carbon; an unfilled portion which is an area in the housing not filled with the activated carbon; a boundary portion that defines a boundary between the filled portion and the unfilled portion; and a center portion which is situated at the axial center of the filled portion. The at least one expansion inhibitor inhibits an expansion of the boundary portion in an outward direction from being greater than an expansion of the center portion in the outward direction. 1. A canister that adsorbs and desorbs fuel vapor generated in a fuel tank of a vehicle , the canister comprising:a housing in a form of a cylinder configured to be filled with activated carbon; andat least one expansion inhibitor,wherein the housing includes a filled portion which is an area in the housing filled with the activated carbon; an unfilled portion which is an area in the housing not filled with the activated carbon; a boundary portion that defines a boundary between the filled portion and the unfilled portion; and a center portion which is situated at the axial center of the filled portion, andwherein the at least one expansion inhibitor is configured to inhibit an expansion of the boundary portion in an outward direction from being greater than an expansion of the center portion in the outward direction.2. The canister according to claim 1 ,wherein the at least one expansion inhibitor is formed on the housing, andwherein a wall thickness of the housing at the at least one expansion inhibitor is thicker than a thickness of periphery of the at least one expansion inhibitor.3. The canister according to claim 1 ,wherein the at least one expansion inhibitor includes at least two ...

A METHOD FOR THE SEPARATION OF C4 OLEFIN MIXTURES

A method for the separation of C4 olefin mixtures using anion-pillared hybrid porous materials as physical adsorbents is provided. The anion-pillared hybrid porous material was constructed by metal ions (M), organic ligand (L), and inorganic anion (A), forming a three-dimensional structure (A-L-M). C4 olefin mixtures contact with hybrid porous materials in certain ways, then each single C4 olefin monomer can be obtained. The pore size of anion-pillared hybrid porous materials and the spatial configurations of the anions within the pores can be fine-tuned and pre-designed. C4 olefins with different size and shape can be efficiently separated by the anion-pillared hybrid porous materials through shape recognition and size-sieving mechanism. 2. The method of separating C4 olefins according to claim 1 , wherein the first kind of organic ligand L1is any of Adenine claim 1 , 2-Amino-6-chloropurine claim 1 , and Guanine.3. The method of separating C4 olefins according to claim 1 , wherein the third kind of organic ligand L3 is any of 4 claim 1 ,4′-bipyridylacetylene claim 1 , 4 claim 1 ,4′-azopyridine claim 1 , 3-hydro-4 claim 1 ,4′-bipyridylacetylene claim 1 , 2-floro-4 claim 1 ,4′-bipyridylacetylene.4. The method of separating C4 olefins according to claim 1 , wherein the organic ligand L1 is Adenine claim 1 , the resulted hybrid porous materials A-L1-M can separate 1-butene and 1 claim 1 ,3-butadiene mixtures with polymer-grade of iso-butene and high purity 1 claim 1 ,3-butadiene obtained; or can separate the mixtures of 1 claim 1 ,3-butadiene claim 1 , 1-butene claim 1 , trans-2-butene claim 1 , iso-butene and cis-2-butene; or can separate 1 claim 1 ,3-butadiene and iso-butene mixtures with polymer-grade of iso-butene obtained; or can separate 1-butene and iso-butene mixtures with polymer-grade of iso-butene obtained; or can separate trans-2-butene and cis-2-butene mixtures with polymer-grade of cis-2-butene and high purity trans-butene obtained.5. The method of ...

CHROMATOGRAPHIC MATERIAL HAVING IMPROVED PH STABILITY, METHOD FOR PREPARATION THEREOF AND USES THEREOF

A chromatographic material including a substrate having a surface and having a polymeric layer covalently bound to the surface; the polymeric layer comprising polymer molecules covalently attached to the surface of the substrate, each polymer molecule being attached to the surface via multiple siloxane bonds and each polymer molecule being connected to one or more functionalizing compounds that each comprise a functional group, wherein the polymeric layer is formed by covalently attaching polymer molecules to the surface of the substrate via multiple siloxane bonds, each polymer molecule containing multiple first reactive groups, and reacting the first reactive groups of the attached polymer molecules with at least one functionalizing compound that comprises a second reactive group that is reactive with the first reactive groups and that further comprises a functional group. Preferred conditions of reacting the polymer with the substrate include elevated temperature and reduced pressure. 1. A method of separating a sample , the method comprising: a substrate having a surface and the substrate having a polymeric layer covalently bound to the surface;', 'the polymeric layer comprising polymer molecules covalently attached to the surface of the substrate, each polymer molecule being attached to the surface via multiple siloxane bonds and each polymer molecule being connected to one or more functionalizing compounds that each comprise a functional group, wherein the functional group comprises C14-C22 alkyl, each polymer molecule containing multiple first reactive groups and multiple silyl groups,', 'wherein the polymeric layer is formed by covalently attaching the polymer molecules to the surface of the substrate via the multiple silyl groups, and reacting the first reactive groups of the attached polymer molecules with the one or more functionalizing compounds, wherein the one or more functionalizing compounds each comprise a second reactive group, wherein the second ...

PACKING MATERIAL FOR HILIC COLUMNS, HILIC COLUMN FILLED WITH SAME, AND METHOD FOR ANALYZING OLIGOSACCHARIDE WITH USE OF SAME

Provided is a packing material for HILIC columns for more accurately and more easily performing oligosaccharide analysis by liquid chromatography; an HILIC column which is filled with the packing material for HILIC columns; and a method for analyzing an oligosaccharide with use of this packing material for HILIC columns A packing material for HILIC columns according to the present invention is composed of particles, each of which is obtained by reacting glycidol to a hydroxyl group of a porous cross-linked polymer base material having the hydroxyl group, and which have a hydrophilicity index of 2.30 or more and a surface-pH index of from 0.95 to 1.05. 1. A packing material for HILIC columns , comprising a cross-linked polymer base material having a hydroxyl group ,wherein the cross-linked polymer base material is porous particles;a glycidol is reacted with the hydroxyl group of the cross-linked polymer base material;a hydrophilicity index is 2.30 or more; and wherein the hydrophilicity index is defined by a separation coefficient of al (U/2dU), when performing a liquid chromatography measurement of a uridine (U) and a 2′-deoxyuridine (2dU) in a HILIC separation mode condition;', 'the surface-pH index is a separation coefficient of α2 (Tb/Tp), when performing a liquid chromatography measurement of a theobromine (Tb) and a theophylline (Tp) in a HILIC separation mode condition;', 'the separation coefficient α1 (U/2dU) and the separation coefficient α2 (Tb/Tp) are ratios of retention factors k of the materials, respectively;', {'sub': 0', '0', '0, 'each retention factor k is defined by k=(t-t)/t, wherein tis an elution time of toluene and, t is an elution time of each substance; and'}, 'a condition of the liquid chromatography measurement in the HILIC separation mode is shown as below:', 'a column temperature is 30° C.; and', 'a mobile phase is a mixed liquid of an acetonitrile and a water solution in a ratio (acetonitrile/water solution) of 90/10 (volume before mixing ...

SOLID SUPPORT WITH A GRAFTED CHAIN

Articles that contain a solid support with a grafted chain extending from the solid support, methods of making these articles, and various uses of the articles are described. More specifically, the grafted chain has a functional group that can react with or interact with target compound. Alternatively, the functional group on the grafted chain can react with a modifying agent to provide another group that can react with or interact with the target compound. The grafted chains are attached to the solid support through a ring-opened azlactone group. The articles can be used to purify the target compound or to separate the target compound from other molecules in a sample. 1. An article comprising a modified grafted support of Formula (V){'br': None, 'sup': 1', '1', '2', '4', '3, 'sub': 2', '2', 'p', '2, 'SS—(CO)—NH—C(R)—(CH)—(CO)-Q-Y-Q-(CO)—CRU—CH—U\u2003\u2003(V)'} SS comprises a solid support in the form of a membrane, foam, film, sheet, or coating on a substrate;', 'p is an integer equal to 0 or 1;', {'sup': '1', 'each Ris each independently selected from alkyl, heteroalkyl, aryl, or aralkyl;'}, {'sup': '1', 'Yis a first linking group comprising an alkylene, heteroalkylene, arylene, or combination thereof;'}, {'sup': 3', '3, 'each Q is independently a divalent group selected from oxy, thio, or —NR— where Ris hydrogen, alkyl, heteroalkyl, aryl, or aralkyl;'}, {'sup': '2', 'each Ris independently hydrogen or an alkyl;'}, {'sup': 3', '2', '2, 'sub': '2', 'Ucomprises at least one divalent monomeric unit of formula CR(YL-T)-CH—;'}, {'sup': '2', 'Yis a second linking group selected from a single bond or a divalent group comprising an alkylene, heteroalkylene, arylene, or combination thereof;'}, {'sup': 3', '2', '2, 'sub': '2', 'Uincludes at least one divalent monomeric unit of formula —CR(YL-T)-CH—;'}, {'sup': 4', '2', '2, 'sub': '2', 'Uis hydrogen or comprises at least one divalent monomeric unit of formula —CR(YL-T)-CH—;'}, {'sup': '1', 'L is an attachment group formed ...

Functionalized Polyamide Stationary Phase for Chromatography and Microwave Assisted Formation Thereof

Chromatography devices and methods for forming and using the devices are described. The devices include a polyimide-based support phase and a polymer grafted to a surface of the polyimide-based support phase. A microwave-assisted graft polymerization protocol is described to form the polymer at the surface of the support phase. Devices can be utilized in high-efficiency separation of macromolecules such as proteins. 1. A separation apparatus comprising;a fluid conduit including a first end and a second end;a support phase disposed within the conduit between the first end and the second end, the support phase comprising a polymeric composition that includes a polyamide at a surface of the support phase;a polymer grafted to the polyamide at the surface of the support phase, the polymer comprising a chromatography functionality for a separation protocol.2. The separation apparatus of claim 1 , wherein the support phase comprises a plurality of fibers or a capillary-channeled polymer fiber claim 1 , wherein the fibers are optionally non-porous.3. The separation apparatus of claim 1 , the chromatographic functionality comprising ion exchange functionality claim 1 , hydrophilic interaction functionality claim 1 , affinity chromatography functionality claim 1 , metal ion separation functionality claim 1 , or combinations thereof.4. The separation apparatus of claim 1 , the chromatographic functionality comprising a carboxylic acid claim 1 , a sulfonate claim 1 , a primary amine claim 1 , a secondary amine claim 1 , a tertiary amine claim 1 , a quaternary amine claim 1 , a hydroxyl claim 1 , an acetic acid claim 1 , a nitrile claim 1 , an amidoxime claim 1 , an ester claim 1 , an azide claim 1 , an alkyne claim 1 , an epoxide claim 1 , or combinations thereof.5. The separation apparatus of claim 1 , wherein the fluid conduit is a single use conduit.6. The separation apparatus of claim 1 , wherein the chromatography functionality is present on the support phase in a density ...

Liquid chromatography packing material

A liquid chromatography packing material employing crosslinked polymer particles, wherein the volume average particle size of the crosslinked polymer particles is at least 2 μm but not more than 10 μm, the amount of fine particles having a particle size of 1 μm or less among the crosslinked polymer particles is less than 1% by volume, and the identity coefficient in the particle size distribution is not more than 1.15.

Rigid and contorted divinyl crosslinkers

Polymerizable compositions containing rigid and contorted divinyl crosslinkers and polymeric materials prepared from the polymerizable compositions are described. The crosslinkers have a spirobisindane-type structure and can undergo free radical polymerization reactions. Methods of preparing the polymeric materials from the polymerizable compositions are also described.

Granulated Zeolites With High Adsorption Capacity for Adsorption of Organic Molecules

The invention relates to granulated zeolites with high adsorption capacity for organic molecules and the use of the zeolites for adsorbing organic molecules from liquids or gas streams.

Functionalized Particulate Support Material and Methods of Making and Using the Same

Functionalized particulate support material suitable for use in chromatography columns or cartridges, such as in a liquid chromatography (HPLC) column, is disclosed. Chromatography columns or cartridges containing the functionalized particulate support material, methods of making functionalized particulate support material, and methods of using functionalized particulate support material, such as a media in a chromatography column or cartridge, are also disclosed. 1. A functionalized particulate support material comprising:a particle having a particle surface; anda combination of functional groups extending from the particle surface, said combination of functional groups comprising (i) a first set of functional groups that enable polymerization of one or more monomers onto the particle surface via the first set of functional groups, and (ii) a second set of functional groups that increases the wettability of said particle surface.2. The functionalized particulate support material of claim 1 , wherein said second functional group is bonded to said one or more monomers or to the particle surface.3. The functionalized particulate support material of or claim 1 , wherein said particle comprises an inorganic particle.43. The functionalized particulate support material of any one of to claims 1 , wherein said particle comprises a silica particle.54. The functionalized particulate support material of any one of to claims 1 , wherein said particle has a particle size claims 1 , as measured by a median particle dimension claims 1 , ranging from about 1 μm to about 120 μm.65. The functionalized particulate support material of any one of to claims 1 , wherein said particle comprises a porous particle having a particle size claims 1 , as measured by a median particle dimension claims 1 , ranging from about 10 μm to about 120 μm claims 1 , and a median pore size of at least 150 Å.76. The functionalized particulate support material of any one of to claims 1 , wherein said first ...

SILICA AGGREGATE, ADSORBENT, ADSORPTION COLUMN, CLEANING SYSTEM, METHOD FOR TREATING LIQUID, AND METHOD FOR PRODUCING SILICA AGGREGATE

A silica aggregate includes primary silica particles aggregated, the primary silica particles having an average particle size of 1 nm or more and less than 10 nm, the primary silica particles being crosslinked to each other by a bond containing a siloxane bond. 1. A silica aggregate , comprising:primary silica particles aggregated,the primary silica particles having an average particle size of 1 nm or more and less than 10 nm,the primary silica particles being crosslinked to each other by a bond containing a siloxane bond.2. The silica aggregate according to claim 1 , wherein the silica aggregate contains aluminum oxide on at least a portion of a surface thereof.3. The silica aggregate according to claim 2 , wherein a percentage by mass of the aluminum oxide with respect to silica in the silica aggregate is 3% or more by mass.4. The silica aggregate according to claim 1 , wherein the silica aggregate has an average particle size of 10 μm or more and 2 claim 1 ,000 μm or less.5. The silica aggregate according to claim 1 , wherein the primary silica particles have an average particle size of 4 nm or more and 6 nm or less.6. The silica aggregate according to claim 1 , wherein the silica aggregate contains an amino group or an epoxy group on a surface thereof.7. The silica aggregate according to claim 1 , wherein the silica aggregate is used for adsorption of a metal ion.8. The silica aggregate according to claim 7 , wherein the metal ion is an ion containing at least one element selected from the group consisting of cesium claim 7 , strontium claim 7 , ruthenium claim 7 , lead claim 7 , cadmium claim 7 , zinc claim 7 , copper claim 7 , iron claim 7 , nickel claim 7 , silver claim 7 , rhodium claim 7 , palladium claim 7 , and iridium.9. The silica aggregate according to claim 1 , further comprising:DNA immobilized on the silica aggregate.10. The silica aggregate according to claim 9 , wherein the silica aggregate has a DNA content of 1% or more by mass and 50% or less ...

METHOD FOR PRODUCING A FRACTION OF XENON RADIOISOTOPES, IN PARTICULAR XE-133, FRACTION OF XENON RADIOISOTOPES, IN PARTICULAR XE-133

A method for producing a fraction of xenon radioisotopes, comprising the steps of dissolving enriched uranium targets forming a slurry and a gaseous phase containing xenon radioisotopes, isolating the xenon radioisotopes using zeolite doped with silver, preferably chosen from the group consisting of aluminosilicates doped with silver, titanosilicates doped with silver and mixtures thereof, and recovering the fraction of xenon radioisotopes, in particular Xe-133. 1. A method for producing a fraction of xenon radioisotopes , comprising the steps of:(iv) dissolving enriched uranium targets by contacting with base to provide an alkaline slurry containing aluminum salts and isotopes generated from the fission of highly-enriched uranium and a gaseous phase containing xenon radioisotopes, as a fission product of uranium,(v) isolating the gaseous phase containing said Xenon radioisotopes, and(vi) recovering a fraction containing said xenon radioisotopes,wherein said uranium targets are low-enriched uranium targets and said isolation of said gaseous phase containing said xenon radioisotopes, comprises a step of adsorbing Xenon radioisotopes on a zeolite doped with silver.2. The method for producing a fraction of xenon radioisotopes according to claim 1 , further comprising a step of flushing said alkaline slurry with a rare gas making it possible to drive said gaseous phase containing said xenon radioisotopes for the purpose of isolating it.3. The method for producing a fraction of xenon radioisotopes according to claim 1 , wherein said zeolite is an aluminosilicate zeolite of the chabazite type claim 1 , doped with silver.4. The method for producing a fraction of xenon radioisotopes according to claim 1 , wherein said zeolite is a titanosilicate zeolite of the ETS type claim 1 , preferably ETS-10 claim 1 , doped with silver.5. The method for producing a fraction of xenon radioisotopes according to claim 1 , wherein said recovery of a fraction containing said xenon ...

Porous composite particulate materials, methods of making and using same, and related apparatuses

In an embodiment, a porous composite particulate material includes a plurality of composite particles. Each composite particle includes an acid-base-resistant core particle at least partially surrounded by one or more layers of acid-base-resistant shell particles. The shell particles are adhered to the core particle by a polymeric layer. The shell particles and/or core particles may be made from an acid-base-resistant material that is stable in harsh chemical conditions. For example, the shell particles may be made from diamond, graphitic carbon, silicon carbide, boron nitride, tungsten carbide, niobium carbide, zirconia, noble metals, combinations of the foregoing, or other acid-base-resistant materials and the core particle may include at least one exterior layer of non-diamond carbon. The porous composite particulate materials disclosed herein and related methods and devices may be used in separation technologies, including, but not limited to, chromatography and solid phase extraction.

Chemically Modified Graphene

This disclosure relates to graphene derivatives, as well as related devices including graphene derivatives and methods of using graphene derivatives.

Separation method and analysis method

A sample, carbon dioxide in a supercritical state, and a modifier are introduced into a separation column disposed on the upstream side of a back pressure control valve, and components included in the sample are separated. The separation column is packed with polymer beads as a packing material. The sample thus separated may be further supplied to an analysis by chromatography and/or a mass analysis.

METHOD FOR PREPARING AN ADSORBENT MATERIAL COMPRISING A STEP OF BASIC MIXING, AND METHOD FOR EXTRACTING LITHIUM FROM SALINE SOLUTIONS USING SAID MATERIAL

The present invention relates to the field of solid materials for the adsorption of lithium. In particular, the present invention relates to a new method for the preparation of a crystallized and shaped solid material, preferably in extruded form, of formula LiX.2Al(OH),nHO, wherein n is between 0.01 and 10, x is 1 when X is an anion selected from among chloride, hydroxide and nitrate anions, and x is 0.5 when X is an anion selected from among sulfate and carbonate anions, comprising a boehmite precipitation step a) under specific temperature and pH conditions, at least one basic mixing shaping step, wherein the method also comprises a final hydrothermal treatment step, all to increase the lithium adsorption capacity and the kinetics of adsorption of the materials obtained, compared with the materials of the prior art when it is used in a method for lithium extraction from saline solutions. 1. Method for preparing a crystallized solid material of formula LiX.2Al(OH) , nHO , wherein n is between 0.01 and 10 , and x is equal to 1 when X is an anion selected from the group consisting of chloride , hydroxide and nitrate anions , and x is 0.5 when X is an anion selected from the group consisting of sulfate and carbonate anions , wherein the method comprises at least the following steps:a) precipitating boehmite, in an aqueous medium, of at least one basic precursor selected from the group consisting of among sodium aluminate, potassium aluminate, aqueous ammonia, sodium hydroxide and potassium hydroxide; and at least one acidic precursor selected selected from the group consisting of aluminum sulphate, aluminum chloride,aluminum nitrate, sulfuric acid, hydrochloric acid, and nitric acid, wherein at least one of one of the basic or acidic precursors comprises aluminum, to obtain a boehmite suspension, step a) operating at a temperature of between 5 and 35° C., and the amount of the basic precursor is chosen in order to obtain a pH of end of precipitation in the reaction ...

Process for preparing an adsorbing material comprising a precipitating step of boehmite according to specific conditions and process for extracting lithium from saline solutions using this material

The present invention relates to the field of solid materials for adsorption of lithium. In particular, the present invention relates to a novel method for preparing a crystallized and shaped solid material, preferably as extrudates, of formula LiXx.2Al(OH)3, nH2O with n being comprised between 0.01 and 10, x being equal to 1 when X is an anion selected from among chloride, hydroxide and nitrate anions, and x being equal to 0.5 when X is an anion selected from among sulfate and carbonate anions, comprising a step a) for precipitation of boehmite under specific temperature and pH conditions, at least one shaping step, preferably by extrusion, said method also comprising a final hydrothermal treatment step, the whole giving the possibility of increasing the adsorption capacity for lithium as well as the adsorption kinetics of the materials obtained as compared with the materials of the prior art when the latter is used in a method for extracting the lithium from saline solutions.

Separation Medium

A separation medium for use in the separation of analytes from a feed stream containing suspended solids, processes of separation using the separation medium, and the use of the separation medium to separate analytes from a feed stream containing suspended solids. The separation medium is provided as a hydrogel having a structure whose surfaces are defined by a triply periodic minimal surface, the hydrogel comprising at least one ligand that binds at least one target analyte. 120.-. (canceled)21. A separation medium comprising a hydrogel having a structure whose surfaces are defined by a triply periodic minimal surface , the hydrogel comprising at least one ligand that binds at least one target analyte.22. The separation medium according to wherein the structure of the hydrogel is selected from the group comprising a Schoen gyroid structure claim 21 , a Schwarz diamond structure claim 21 , a Schwartz Primitive structure and a Schoen IWP structure.23. The separation medium according to wherein the structure of the hydrogel is a gyroid structure.24. The separation medium according to wherein the hydrogel is a thermoresponsive hydrogel.25. The separation medium according to wherein the hydrogel is a polysaccharide hydrogel claim 21 , for example claim 21 , an agarose or cellulose hydrogel.26. The separation medium according to wherein the hydrogel is functionalised with a ligand for use in ion exchange chromatography or hydrophobic interaction chromatography claim 21 , preferably cation exchange claim 21 , preferably anion exchange.27. A chromatographic apparatus comprising a separation medium wherein the separation medium is comprised of a hydrogel having a structure whose surfaces are defined by a triply periodic minimal surface claim 21 , the hydrogel comprising at least one ligand that binds at least one target analyte.28. The chromatographic apparatus according to claim 27 , wherein the separation medium is comprised in or is in the form of a column.29. A process ...

Porous Silica Particles

The present disclosure provides a porous silica having an average pore diameter of at least 210 Å and a pore volume of at least 0.80 cmg. The present disclosure also provides a method of producing the porous silica including gelling a liquid phase-dispersed nanoparticulate silica in the presence of either (i) a Brønsted acid and an amine group having two or more primary or secondary amine groups or (ii) an amino acid. 1. A porous silica having an average pore diameter of at least 210 Å and a pore volume of at least 0.80 cmg.2. The porous silica as set forth in claim 1 , wherein the average pore diameter is up to 500 Å and/or the pore volume is up to 1.2 cmg.3. The porous silica as set forth in claim 1 , wherein one or more of the following conditions apply:{'sup': 3', '−1, '(i) the pore volume is at least 0.84 cmg;'}{'sup': 3', '−1, '(ii) the pore volume is up to 1.0 cmg;'}(iii) the average pore diameter is at least 250 Å;(iv) the average pore diameter is up to 450 Å;{'sup': 2', '−1, '(v) the porous silica has a specific surface area of from 50 to 500 mg;'}(vi) the porous silica has a surface modified with one or more organic groups;(vii) the porous silica has a pore size distribution of from 0.10 to 2.30; and(viii) the porous silica is in solid form.4. A process for producing a porous silica having an average pore diameter of at least 210 Å and a pore volume of at least 0.80 cmg claim 1 , the process comprising the step of gelling a liquid phase-dispersed nanoparticulate silica in the presence of either (i) a Brønsted acid and an amine compound having two or more amine groups selected from primary amine groups and secondary amine groups or (ii) an amino acid.5. The process as set forth in claim 4 , wherein the nanoparticulate silica has primary particles having an average diameter of from 2 to 200 nm claim 4 , and/or the liquid-phase dispersion of nanoparticulate silica is a water-in-oil emulsion or dispersion with the aqueous phase comprising the nanoparticulate ...

Composite adsorbent bead, process for its production, gas separation process and gas adsorption bed

Composite adsorbent beads have a porous and non-adsorbent core comprising at least one inorganic material and a porous and adsorbent shell comprising at least one adsorbent layer comprising a porous adsorbent material on the surface of the core. The core preferably comprises agglomerated inorganic particles having a mean particle size equal to or smaller than the mean particle size of the surrounding agglomerated adsorbent particles. The beads preferably are manufactured by calcining together a non-sintered core and the adsorbent layer. The beads can be used at the outlet end of an adsorption column to improve performance.

Novel affinity ligands and their use

The present invention relates to novel affinity ligand-matrix conjugates comprising a ligand with general formula (a), which ligand is attached to a support matrix in position (A), optionally through a spacer arm interposed between the matrix and ligand. The invention furthermore relates to these novel affinity ligand-matrix conjugates and the preparation and use thereof in the purification of proteinaceous materials such as e.g. immunoglobulins, insulins, Factor VII, or human Growth Hormone or analogues, derivates and fragments thereof and precursors.

Zinc-oxide-based sorbents and processes for preparing and using same

The disclosure relates to zinc oxide-based sorbents, and processes for preparing and using them. The sorbents are preferably used to remove one or more reduced sulfur species from gas streams. The sorbents comprise an active zinc component, optionally in combination with one or more promoter components and/or one or more substantially inert components. The active zinc component is a two phase material, consisting essentially of a zinc oxide (ZnO) phase and a zinc aluminate (ZnAl 2 O 4 ) phase. Each of the two phases is characterized by a relatively small crystallite size of typically less than about 500 Angstroms. Preferably the sorbents are prepared by converting a precursor mixture, comprising a precipitated zinc oxide precursor and a precipitated aluminum oxide precursor, to the two-phase, active zinc oxide containing component.

Zinc oxide-based sorbents and processes for preparing and using same

The disclosure relates to zinc oxide-based sorbents, and processes for preparing and using them. The sorbents are preferably used to remove one or more reduced sulfur species from gas streams. The sorbents comprise an active zinc component, optionally in combination with one or more promoter components and/or one or more substantially inert components. The active zinc component is a two phase material, consisting essentially of a zinc oxide (ZnO) phase and a zinc aluminate (ZnAl 2 O 4 ) phase. Each of the two phases is characterized by a relatively small crystallite size of typically less than about 500 Angstroms. Preferably the sorbents are prepared by converting a precursor mixture, comprising a precipitated zinc oxide precursor and a precipitated aluminum oxide precursor, to the two-phase, active zinc oxide containing component.

Zinc-oxide-based sorbents and processes for preparing and using same

Zinc oxide-based sorbents, and processes for preparing and using them are provided. The sorbents are preferably used to remove one or more reduced sulfur species from gas streams. The sorbents comprise an active zinc component, optionally in combination with one or more promoter components and/or one or more substantially inert components. The active zinc component is a two phase material, consisting essentially of a zinc oxide (ZnO) phase and a zinc aluminate (ZnAl 2 O 4 ) phase. Each of the two phases is characterized by a relatively small crystallite size of typically less than about 500 Angstroms. Preferably the sorbents are prepared by converting a precursor mixture, comprising a precipitated zinc oxide precursor and a precipitated aluminum oxide precursor, to the two-phase, active zinc oxide containing component.

Process for preparing zinc oxide-based sorbents

The disclosure relates to zinc oxide-based sorbents, and processes for preparing and using them. The sorbents are preferably used to remove one or more reduced sulfur species from gas streams. The sorbents comprise an active zinc component, optionally in combination with one or more promoter components and/or one or more substantially inert components. The active zinc component is a two phase material, consisting essentially of a zinc oxide (ZnO) phase and a zinc aluminate (ZnAl 2 O 4 ) phase. Each of the two phases is characterized by a relatively small crystallite size of typically less than about 500 Angstroms. Preferably the sorbents are prepared by converting a precursor mixture, comprising a precipitated zinc oxide precursor and a precipitated aluminum oxide precursor, to the two-phase, active zinc oxide containing component.

SPHERICAL SIO (DOWN ARROW) 2 (DOWN ARROW) PARTICLES

Porous composite particulate materials, methods of making and using same, and related apparatuses

In an embodiment, a porous composite particulate material includes a plurality of composite particles. Each composite particle includes an acid-base-resistant core particle at least partially surrounded by one or more layers of acid-base-resistant shell particles. The shell particles are adhered to the core particle by a polymeric layer. The shell particles and/or core particles may be made from an acid-base-resistant material that is stable in harsh chemical conditions. For example, the shell particles and/or core particles may be made from diamond, graphitic carbon, silicon carbide, boron nitride, tungsten carbide, niobium carbide, zirconia, noble metals, acid-base stable highly cross-linked polymers, acid-base stable at least partially cross-linked polymers, titania, alumina, thoria combinations of the foregoing, or other acid-base-resistant materials. The porous composite particulate materials disclosed herein and related methods and devices may be used in separation technologies, including, but not limited to, chromatography and solid phase extraction.

Porous composite particulate materials, methods of making and using same, and related apparatuses

In an embodiment, a porous composite particulate material includes a plurality of composite particles. Each composite particle includes an acid-base-resistant core particle at least partially surrounded by one or more layers of acid-base-resistant shell particles. The shell particles are adhered to the core particle by a polymeric layer. The shell particles and/or core particles may be made from an acid-base-resistant material that is stable in harsh chemical conditions. For example, the shell particles and/or core particles may be made from diamond, graphitic carbon, silicon carbide, boron nitride, tungsten carbide, niobium carbide, zirconia, noble metals, acid-base stable highly cross-linked polymers, acid-base stable at least partially cross-linked polymers, titania, alumina, thoria combinations of the foregoing, or other acid-base-resistant materials. The porous composite particulate materials disclosed herein and related methods and devices may be used in separation technologies, including, but not limited to, chromatography and solid phase extraction.

Method for producing adsorbent materials for liquid chromatography using zwitterionic silanes

Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von mit zwitterionischen Silanen modifizierten Adsorbentien für die Flüssigchromatographie, ein Adsorbens, das nach diesem Verfahren hergestellt ist, eine Chromatographiesäule, die ein solches Adsorbens enthält sowie schließlich die Verwendung einer derartigen Chromatographiesäule für die Flüssigchromatographie. The present invention relates to a process for the preparation of zwitterionic silane-modified adsorbents for liquid chromatography, to an adsorbent prepared by this process, to a chromatography column containing such an adsorbent, and finally to the use of such a chromatographic column for liquid chromatography.

Use of zwitterionic adsorbents for liquid chromatography, chromatography column with such adsorbents and their use

Verwendung von zwitterionischen Adsorbentien für die Flüssigchromatographie, wobei die Adsorbentien einen festen Träger haben, der eine poröse Struktur hat, und wobei die Adsorbentien nach einem Verfahren hergestellt sind, das die folgenden Schritte umfasst: a) Umsetzen einer Silanverbindung der allgemeinen Formel I(Formel I) mit entweder einer Sulfonsäureverbindung der allgemeinen Formel II(Formel II) oder mit einer Sulfonsäureverbindung der allgemeinen Formel III(Formel III), ... Use of zwitterionic adsorbents for liquid chromatography, the adsorbents having a solid support having a porous structure, and wherein the adsorbents are prepared by a process comprising the steps of: a) reacting a silane compound of general formula I (Formula I) ) with either a sulfonic acid compound of the general formula II (formula II) or with a sulfonic acid compound of the general formula III (formula III),

Adsorption carrier-packed column

Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same

Improvements in the existing procedures and materials for conduct of high gradient magnetic separation (HGMS) are disclosed. Superior superparamagnetic particles, optionally coated with a polysaccharide or other, usually organic, materials can be prepared in uniform compositions with homogeneous magnetizations. The coating can conveniently be conjugated to a specific binding moiety complementary to a biological material whose purification or separation is desired. In addition, plastic coated matrices which form superior magnetic gradient-intensifying supports are disclosed, along with improved methods and apparatus to conduct HGMS.

Methods for coating metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same

Improvements in the existing procedures and materials for conduct of high gradient magnetic separation (HGMS) are disclosed. Superior superparamagnetic particles, optionally coated with a polysaccharide or other, usually organic, materials can be prepared in uniform compositions with homogeneous magnetizations. The coating can conveniently be conjugated to a specific binding moiety complementary to a biological material whose purification or separation is desired. In addition, plastic coated matrices which form superior magnetic gradient-intensifying supports are disclosed, along with improved methods and apparatus to conduct HGMS.

Novel affinity ligands and their use

Novel ion exchange porous resins for solid phase extraction and chromatography

Porous titania spheres

Porous titania or zirconia spheres having a particle diameter of about 1 to 100 microns, a pore volume of about 0.1 to 1 cc/g, and a pore diameter in the range of about 10 to 5,000 Angstrom units are made by spray drying a slurry of ultimate titania or zirconia particles having a diameter about equal to that of the desired pore diameter of the formed sphere, and a reactive binder. The spheres can be used in high performance liquid chromatography columns and as catalyst supports.

Silane-modified clay

Clay particles with organo silane-modified surfaces are provided along with a process for their preparation. The silane-modified clay is relatively easily and reliably produced by reacting clay with a R-substituted halosilane (R being a hydrophobic group) in a polar solvent containing a tertiary amine. The produced silanized clay is stable over a wide range of storage and use conditions. Contacting processes for using the silane-modified clay to remove organic contaminants from aqueous media are also provided. After use, the silane-modified clay particles can be regenerated, treated and reused for such contaminant removal.

Procedimento per la purificazione di acque contenenti prodotti organici,mediante estrazione dei detti prodotti organici per mezzo di un solvente immobilizzato

具有改进的pH稳定性的色谱材料、其制备方法和其用途

一种色谱材料，其包括具有表面的基质且所述基质具有共价结合至所述表面的聚合层；所述聚合层包含共价连接到所述基质的表面的聚合物分子，每一聚合物分子经由多个硅氧烷键连接到表面且每一聚合物分子连接到一或多个各自包含官能团的官能化化合物，其中所述聚合层如下形成：经由多个硅氧烷键将聚合物分子共价连接至所述基质的所述表面，每一聚合物分子含有多个第一反应性基团，且使所述连接的聚合物分子的所述第一反应性基团与至少一种官能化化合物反应，所述化合物包含与所述第一反应性基团反应的第二反应性基团且进一步包含官能团。使所述聚合物与所述基质反应的优选的条件包括高温和减压。

グラフト化鎖を伴う固体支持体

特异吸附c‑Myc标签单域重链抗体的免疫亲和材料

本发明属于基因工程领域，具体为针对c‑Myc标签的单域重链抗体(又称纳米抗体)，其具有SEQ ID NO.1所示的氨基酸序列。本发明所提供的氨基酸序列可以作为前体，通过随机或定点突变技术进行改造，能够获得性质(亲和性、特异性、稳定性等)更好的突变体，该高特异性的纳米抗体可作为针对c‑Myc的免疫亲和吸附材料，对含有c‑Myc标签的重组蛋白进行纯化。

Solid support with a grafted chain

Articles that contain a solid support with a grafted chain extending from the solid support, methods of making these articles, and various uses of the articles are described. More specifically, the grafted chain has a functional group that can react with or interact with target compound. Alternatively, the functional group on the grafted chain can react with a modifying agent to provide another group that can react with or interact with the target compound. The grafted chains are attached to the solid support through a ring-opened azlactone group. The articles can be used to purify the target compound or to separate the target compound from other molecules in a sample.

旋光异构体分离用填充剂的制造方法

本发明提供一种可在多孔载体上均匀负载多糖衍生物的制造方法。即，在搅拌装置内，通过搅拌操作，使多孔载体与多糖衍生物溶液接触，在多孔载体上负载光学活性高分子化合物的制造方法，其使用立式双轴搅拌装置作为搅拌装置，使多孔载体上负载多糖衍生物的负载量为23质量%或23质量%以上的旋光异构体分离用填充剂的制造方法。

탄화수소혼합물로부터에틸렌및프로필렌,그리고불포화탄화수소분리용흡착제제조방법,그리고이흡착제를이용한분리방법

본 발명은 불포화탄화수소를 선택적으로 흡착시킬 수 있는 매우 안정한 원통형과 구형의 새로운 고체흡착제를 제조하기 위한 방법 및 과정을 제공하고자 하는 것으로서, 이 흡착제들은 ㉠ 은화합물과, ㉡ 상기화합물을 최소한으로 지지해줄 수 있는 충분한 표면적을 지니는 적절한 지지체로 구성되는 혼합물질을 시발로 하여, 이후 이 혼합물질을 함침단계와 열처리단계를 순차적으로 거침으로써 최종적인 흡착제를 제조할 수 있게 된다. 이러한 흡착제 제조과정 중 첨가제(촉진제, promoter)를 선택적으로 부가시킬 수 있다. 본 발명의 또다른 목적은 혼합물로부터 에틸렌 그리고 (혹은) 프로필렌 성분을 선택적으로 분리하는 공정을 제공함에 있다. 이때 혼합물은 에틸렌 그리고 (혹은) 프로필렌 성분 이외에 수소(H 2 ), 헬륨(He), 메테인(CH 4 ), 에테인(C 2 H 6 ), 혹은 프로페인(C 3 H 8 ) 성분으로 이루어진 두 성분 혹은 상기 성분 중의 일부로 구성된 다성분 혼합물를 의미한다. 본 공정은 0℃∼100℃의 온도와 1∼100기압의 압력조건에서 상기 혼합물을 본 흡착제가 충진된 탑에 통과시키고 이 후 압력을 낮추거나 온도를 높임으로써 탈착과정에 의해 고순도의 에틸렌과 (혹은) 프로필렌 생성물을 얻을 수 있다.

利用活性炭从包含靶蛋白的样品去除片段

本发明提供新的和改良的蛋白纯化方法，其涉及某种类型的含碳物质，并且导致高效且选择性地去除蛋白片段而不会不利影响期望的蛋白产物的收率。

Acylated polyethylenimine bound chromatographic packing

This invention relates to the N-acylated covalently bound, non- crosslinked polyethyleneimine reaction product of particulate silicagel having an average particle diameter of about 3-70 μm and average pore size of about 50-1000 angstrom units or particulate controlled pore glass having an average particle diameter of about 37-177 m and an average pore size of 40-1000 anstrom units, with polyethyleneiminopropyl trimethoxy silane having an av. molecular weight of about 400-1800, wherein the N-acyl function ahs the formulas of R-CO-, in which R is a member from the gp. consisting of 1-8C alkyl or phenyl substd. with one or more substituents from the gp. consisting of 1-4C alkyl, 1-4 alkoxy, halo and nitro.

Solid adsorbent for unsaturated hydrocarbon and process for separation of unsaturated hydrocarbon from gas mixture

A solid adsorbent for an unsaturated hydrocarbon com­ prising (a) (i) a silver or copper(I) halide or (ii) a silver or copper(I) halide and the halide of a bivalent metal, or (iii) a silver or copper(I) halide and an aluminum halide, and (b) polystyrene or a derivative thereof. This solid adsorbent can effectively adsorb an unsaturated hydrocarbon such as ethylene from a gas mixture by contact­ ing the gas mixture therewith at a temperature of -40°C to 140°C under normal pressures.

Patent JPS5247355B2

Process for separation of unsaturated hydrocarbon from gas mixture

A solid adsorbent for an unsaturated hydrocarbon comprising (a) (i) a silver or copper(I) halide or (ii) a silver or copper(I) halide and the halide of a bivalent metal, or (iii) a silver or copper(I) halide and an aluminum halide, and (b) polystyrene or a derivative thereof. This solid adsorbent can effectively adsorb an unsaturated hydrocarbon such as ethylene from a gas mixture by contacting the gas mixture therewith at a temperature of -40° C. to 140° C. under normal pressures.

Sorbent based on cross-linked polymer and carbon for removal of heavy metals, toxic materials and carbon dioxide

FIELD: chemistry. SUBSTANCE: invention considers sorbent based on cross-linked polymer and carbon for removal of carbon dioxide, heavy metals, toxic materials in flue gas in result of combustion process at coal-fired power stations. The sorbent contains a carbon-bearing sorbent, cured amine-containing polymer and sulphur. The sorbents based on polymer and carbon are formed in result of curing of amine-containing polymer in presence of carbonic sorbent, sulphur cross-linking agent, a curing accelerator and a curing activating agent optionally. The suitable carbonic sorbent is activated carbon while the suitable amine-containing polymer is allyl-containing poly(ethelyneimine) with average molecular weight from about 1500 up to 10000. The sorbents based on polymer and carbon may contain sulfur exceeding the quantity required for curing of amine-containing polymer. EFFECT: invention allows capturing more mercury in elementary and ionic forms. 14 cl, 9 dwg РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 520 444 C2 (51) МПК B01D 53/02 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2012140446/05, 21.02.2011 (24) Дата начала отсчета срока действия патента: 21.02.2011 (72) Автор(ы): МОХАНТИ Диллип (US) (73) Патентообладатель(и): СЕНТРАЛ МИЧИГАН ЮНИВЕРСИТИ (US) Приоритет(ы): (30) Конвенционный приоритет: (43) Дата публикации заявки: 27.03.2014 Бюл. № 9 R U 22.02.2010 US PCT/US2010/000501 (45) Опубликовано: 27.06.2014 Бюл. № 18 A, 04.07.1967. US 4157438 А, 05.06.1979. БОЛЬШАЯ РОССИЙСКАЯ ЭНЦИКЛОПЕДИЯ" Москва 1995" том 4. RU 2064429 C1, 27.07.1996 (86) Заявка PCT: US 2011/025583 (21.02.2011) C 2 C 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 24.09.2012 (87) Публикация заявки PCT: 2 5 2 0 4 4 4 WO 2011/103529 (25.08.2011) R U 2 5 2 0 4 4 4 (56) Список документов, цитированных в отчете о поиске: US 4305827 A, 15.12.1981. US 3329649 Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, строение 3, ...

Process for regenerating adsorbents with supercritical fluids

An adsorbate is removed from an adsorbent by contacting the adsorbent with a supercritical fluid which is a solvent for the adsorbate. The supercritical fluid containing the dissolved adsorbate is then subjected to a physical treatment which renders the supercritical fluid a nonsolvent for the adsorbate and makes it possible to remove the adsorbate from the supercritical fluid. The supercritical fluid is then subjected to another physical treatment to restore it to a state wherein it is a solvent for the adsorbate so that it may be reused. The process and apparatus are particularly suitable for adsorbent regeneration in the treating of waste water.

焼成されたアルミナ上に二酸化炭素および水不純物を吸着させることにより空気を精製する方法

(57)【要約】 【課題】乾燥され脱炭酸された空気を得ることを可能と するために大気空気流において見出され得るＣＯ 2 およ び水蒸気をともに吸着するためのプロセスを提供するこ と。 【解決手段】二酸化炭素（ＣＯ 2 ）および水蒸気不純物 の少なくともどれほどかは、多くとも１０重量％の少な くとも１種のアルカリ金属酸化物またはアルカリ土類金 属酸化物を含む少なくとも１種の焼成されたアルミナ上 に前記不純物を吸着させることにより除去される、二酸 化炭素および水蒸気を含む空気流を精製するための方法 であって、前記吸着は−１０℃ないし８０℃の温度で実 施される。

FUNCTIONALIZED MATERIAL MATERIAL CONSISTING OF PARTICLES AND METHODS FOR PRODUCING AND USING IT

1. Функционализированный, состоящий из частиц материал носителя, содержащий:частицу, имеющую поверхность частицы; исочетание функциональных групп, исходящих из поверхности частицы, где указанное сочетание функциональных групп включаетa) (i) первый ряд функциональных групп, которые позволяют полимеризацию одного или более мономеров на поверхности частицы через первый ряд функциональных групп, и (ii) второй ряд функциональных групп, которые повышают смачиваемость указанной поверхности частицы,и/илиb) (i) первый ряд функциональных групп, связанный с, по крайней мере, одним полимером, исходящим из поверхности частицы, и (ii) второй ряд функциональных групп, которые повышают смачиваемость указанной поверхности частицы.2. Функционализированный, состоящий из частиц материал носителя по п. 1, где указанная частица содержит частицу двуокиси кремния.3. Функционализированный, состоящий из частиц материал носителя по п. 1, где указанный первый ряд функциональных групп содержит ненасыщенные связи.4. Функционализированный, состоящий из частиц материал носителя по п. 1, где указанный второй ряд функциональных групп содержит, по крайней мере, одну гидрофильную органическую группу.5. Функционализированный, состоящий из частиц материал носителя по пп. 3-4, где указанный первый ряд функциональных групп включает винильные группы, и указанный второй ряд функциональных групп включает диольные группы.6. Функционализированный, состоящий из частиц материал носителя по п. 5, где указанные первый и второй ряд функциональных групп являются частью молекулы, содержащей азогруппы и группы карбоновой кислоты.7. Функционализированный, состоящий из частиц материал носителя по РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (51) МПК C07F 7/18 (11) (13) 2015 114 177 A (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2015114177, 16.09.2013 (71) Заявитель(и): У.Р. ГРЕЙС ЭНД КО.-КОНН. (US) Приоритет(ы): (30) Конвенционный приоритет: (72) Автор(ы): ГУ Фын (US) 17.09. ...

Activated polymer solid bodies and processes for the production thereof

A chemically modified and activated, hydroxyl-group-containing, natural or synthetic, polymeric solid body surface is disclosed, as well as a process for the activation of such solid body surfaces by means of organo-silanes and, if necessary, homo- or heterobifunctional reagent. The surfaces are used for the stable, simple and economical binding of proteins, nucleic acids, low-molecular ligands, cells, microorganisms and other biological materials, in biology, biotechnology and medicine.

Porous titania or zirconia spheres

Porous titania or zirconia spheres having a particle diameter of about 1 to 100 microns, a pore volume of about 0.1 to 1 cc/g, and a pore diameter in the range of about 10 to 5,000 Angstrom units are made by spray drying a slurry of ultimate titania or zirconia particles having a diameter about equal to that of the desired pore diameter of the formed sphere, and a reactive binder. The spheres can be used in high performance liquid chromatography columns and as catalyst supports.

High capacity regenerable sorbent for removing arsenic and other toxic ions from drinking water

The present invention is directed to a sorbent comprising a disordered polyvalent metal oxide on the surface of an inert substrate. The substrate can be a layered silicate, such as vermiculite, an aluminosilicate such as montmorillonite, or a nonlayered silicate such as a zeolite. The sorbent removes ionic contaminants, such as arsenic, from process streams.

Porous inorganic support material coated with an organic stationary phase, for use in chromatography, and process for its preparation

POROUS INORGANIC SUPPORT MATERIAL COATED WITH AN ORGANIC STATIONARY PHASE, FOR USE IN CHROMATOGRAPHY, AND PROCESS FOR ITS PREPARATION. ABSTRACT The invention relates to support material usable as such in chromatography or as a starting material which, upon linkage to it of compounds containing ionic groups, ligands or biomacro-molecules, can be used as ion exchanger, as a medium in affinity chromatography or in enzymatic reactions and consists of porous, inorganic silanized particles onto which there is covalently bonded an organic, stationary phase built up of (co)polymerized vinyl monomers containing amide groups, said inorganic particles having been silanized with an organo silane of the formula I

Adsorbents and methods for the separation of ethylene and propylene and/or unsaturated hydrocarbons from mixed gases

Adsorbents useful in the selective adsorption of unsaturated hydrocarbons, the manufacture of the adsorbents, and processes for the separation of unsaturated hydrocarbons using the adsorbents.

Substrate for analyzing hydrophilic substances having low molecular weight

TITLE OF THE INVENTION: A SUBSTRATE FOR ANALYZING HYDROPHILIC SUBSTANCES HAVING LOW MOLECULAR WEIGHT ABSTRACT OF THE DISCLOSURE: A porous substrate for analyzing hydrophilic substances having low molecular weight, comprising a cross-linked copolymer having methylol groups, the copolymer being made of a monomer of styrene-series and a cross-linking agent copolymerizable with the monomer, the outer surface thereof being hydrophilic and the inner surface of pores thereof being hydrophobic, is prepared by sub-jecting a mixture of the monomer and the cross-linking agent to suspension polymerization in water in the presence of a pore regulator and a water-soluble polymer and providing the resultant cross-linked copolymer with methylol groups.

Coated polydivinylbenzene beads

The present invention provides novel, polymeric supports, methods of making, and methods of using the supports, that have a fluorinated, amidated surface. The supports include polymeric microbeads, thin layers or membranes, plates, monoliths and the like. The supports are useful as packing materials for normal phase, reverse phase, and size exclusion chromatography, and provide high speed separation of analytes with excellent resolution. The fluorinated, amidated surface may include a composition comprising a plurality of repeating units, for example, having the following structure:

Coated polydivinbenzene beads

The present invention provides novel, polymeric supports, methods of making, and methods of using the supports, that have a fluorinated, amidated surface. The supports include polymeric microbeads, thin layers or membranes, plates, monoliths and the like. The supports are useful as packing materials for normal phase, reverse phase, and size exclusion chromatography, and provide high speed separation of analytes with excellent resolution. The fluorinated, amidated surface may include a composition comprising a plurality of repeating units, for example, having the following structure:

Coated polydivinylbenzene beads

The present invention provides novel, polymeric supports, methods of making, and methods of using the supports, that have a fluorinated, amidated surface. The supports include polymeric microbeads, thin layers or membranes, plates, monoliths and the like. The supports are useful as packing materials for normal phase, reverse phase, and size exclusion chromatography, and provide high speed separation of analytes with excellent resolution. The fluorinated, amidated surface may include a composition comprising a plurality of repeating units, for example, having the following structure:

Devices and methods for the purification, isolation, desalting or buffer/solvent exchange of substances

一种旋转柱装置，包含刚性多孔过滤器，该刚性多孔过滤器在离心分离过程中仍保持其形状；层析方法，使用上述装置将所需物质例如生物分子从混合物中的其它物质中分离；以及套件，包含具有用于上述方法中的一种或多种试剂的装置。

Zinc oxide-based sorbents and processes for preparing and using same

본 발명은 산화아연계 수착제, 및 이를 제조 및 사용하는 방법에 관한 것이다. 수착제는 바람직하게는 하나 이상의 환원된 황 종을 가스 스트림으로부터 제거하는데 사용한다. 수착제는 활성 아연 성분을, 경우에 따라 1종 이상의 촉진제 성분 및/또는 1종 이상의 실질적으로 불활성 성분과 함께 포함한다. 활성 아연 성분은 본질적으로 산화아연(ZnO) 상 및 알루민산아연(ZnAl 2 O 4 ) 상으로 이루어진 2상 물질이다. 각각의 2상은 전형적으로 미세결정 크기가 약 500 Å 미만으로 비교적 작은 것을 특징으로 한다. 바람직하게는 수착제는 침전 산화아연 전구체 및 침전 산화알루미늄 전구체를 포함하는 전구체 혼합물을 2상의 활성 산화아연을 포함하는 성분으로 전환시켜 제조한다. The present invention relates to zinc oxide sorbents and methods of making and using the same. The sorbent is preferably used to remove one or more reduced sulfur species from the gas stream. The sorbents comprise the active zinc component, optionally with one or more promoter components and / or one or more substantially inert components. The active zinc component is essentially a biphasic material consisting of a zinc oxide (ZnO) phase and a zinc aluminate (ZnAl 2 O 4 ) phase. Each two phase is typically characterized by a relatively small microcrystal size of less than about 500 GPa. Preferably the sorbent is prepared by converting a precursor mixture comprising a precipitated zinc oxide precursor and a precipitated aluminum oxide precursor into a component comprising two phases of active zinc oxide.

Patent JPS5924854B2

Removal of fragments from a sample containing a target protein using activated carbon

본 발명은 특정 유형의 탄소질 물질을 포함하는 신규하고 개선된 단백질 정제 공정을 제공하며, 소망하는 단백질 생성물 수율에 나쁜 영향을 주지 않고도 단백질 단편의 선택적 제거를 초래한다. The present invention provides a new and improved protein purification process involving certain types of carbonaceous materials and results in the selective removal of protein fragments without adversely affecting the desired protein product yield.

Purification of immunoglobulins

本发明涉及一种分离基质，该分离基质包含固定有配体的多孔载体，其中所述配体包含至少一种脂族磺酰胺。磺酰胺的氮可以是仲胺或叔胺。本发明也涉及装有所述分离基质的层析柱，以及通过将免疫球蛋白样化合物吸附到包含了脂族磺酰胺配体的分离基质上进行分离的方法。

Porous molded body, and method and apparatus for manufacturing porous molded body

Fiber construct for treating biological components

본 발명은 극세 섬유로 이루어지는 섬유 구조체이면서, 소형 컬럼에 충전해도 섬유간의 공극을 안정되게 유지할 수 있는 섬유 구조체의 제공을 목적으로 하고, 평균 직경이 50㎛ 미만의 섬유로 이루어지고, 상기 섬유의 일부는 권축을 갖는 생체 성분 처리 재료용 섬유 구조체를 제공한다. The present invention provides a fiber structure which is a fiber structure made of ultrafine fibers and which can stably maintain voids between fibers even when filled in a small column and is made of fibers having an average diameter of less than 50 탆, Provides a fibrous structure for a biocomponent treatment material having crimps.

Method for producing novel separating agent for optical isomer separation

Method of purification of oxydaze of d-aminoacids

Method for separating carbon tetraolefin mixture

本发明公开了一种碳四烯烃混合物的分离方法，以离子杂化多孔材料为分离材料，采用特定的分离介质与碳四烯烃接触的方式，从碳四烯烃混合物中分离出单个碳四烯烃；所述离子杂化多孔材料为由金属离子、无机阴离子和有机配体通过配位键形成的多孔材料通式为A‑L‑M。本发明首次提供了一种离子杂化多孔材料吸附分离C4烯烃的方法，精准调控离子杂化多孔材料的孔径以及阴离子空间几何分布，择形和尺寸筛分效应，实现不同尺寸和形状的C4烯烃各组分的选择性分离。

Porous inorganic/organic hybrid particles for chromatographic separations and process for their preparation

Novel material for chromatographic separations, processes for its preparation, and separations devices containing the chromatographic material. In particular, the disclosure describes porous inorganic/organic hybrid particles having a chromatographically-enhancing pore geometry, which desirably may be surface modified, and that offer more efficient chromatographic separations than that known in the art.

Porous inorganic/organic hybrid monolith materials for chromatographic separations and process for their preparation

Novel materials for chromatographic separations, processes for their preparation, and separation devices containing the chromatographic materials. In particular, the novel materials are porous inorganic/organic hybrid monolith materials, which desirably may be surface modified, and which offer more efficient chromatographic separations than that known in the art.

MATERIALS FOR A HYDROPHILIC INTERACTION CHROMATOGRAPHY AND METHOD FOR THE PREPARATION AND USE THEREOF FOR THE ANALYSIS OF GLYCOPROTEINS AND GLYCOPEPTIDES

Die Erfindung betrifft Polyamid-gebundene stationäre Phasen für die hydrophile Interaktionschromatographie (HILIC) und neue HILIC-Verfahren zur Verwendung bei der Charakterisierung von großen biologischen Molekülen, die mit polaren Gruppen modifiziert und dem Fachmann als Glykane bekannt sind. Erfindungsgemäß werden insbesondere neue, Polyamid-gebundene Materialien bereitgestellt, die für eine effiziente Auftrennung von großen Biomolekülen entworfen sind, z. B. Materialien mit einem großen Prozentsatz an großen Poren (d. h. weiten Poren). Ferner werden erfindungsgemäß vorteilhafterweise neue HILIC-Verfahren bereitgestellt, die in Kombination mit den hierin beschriebenen Materialien der stationären Phase verwendet werden können, um effektiv Protein- und Peptidglykoformen dadurch aufzutrennen, dass früher ungelöste Probleme, wie Aggregation von Proteinproben auf der Säule, geringe Empfindlichkeit eines chromatographischen Nachweises der Glykanreste und geringe Auflösung von Peaks aufgrund von beschränkter Porendiffusion und langen Diffusionswegen innerhalb/zwischen Partikeln, eliminiert werden. This invention relates to polyamide-linked stationary phases for hydrophilic interaction chromatography (HILIC) and to novel HILIC methods for use in the characterization of large biological molecules modified with polar groups and known to those skilled in the art as glycans. In particular, according to the invention, new polyamide-bound materials are provided which are designed for efficient separation of large biomolecules, e.g. B. Materials with a large percentage of large pores (i.e., wide pores). Further, according to the present invention, advantageously new HILIC methods are provided which can be used in combination with the stationary phase materials described herein to effectively separate protein and peptide glycoforms by addressing previously unresolved issues such as aggregation of protein samples on the column chromatographic detection of the glycan residues and ...

High purity chromatographic materials comprising an ionizable modifier

The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are high purity chromatographic materials comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifier

High purity chromatographic materials comprising an ionizable modifier

The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are high purity chromatographic materials comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifier.

Porous hybrid particles with organic groups removed from the surface

A material for chromatographic separations, processes for its preparation, and separation devices containing the chromatographic material. In particular, porous inorganic/organic hybrid materials are provided with a decreased concentration of surface organic groups. These particles may be surface modified and have enhanced stability at low pH.

Monolithic organic copolymer

Monolithic organic copolymer prepared by copolymerisation of a phenyl (meth)acrylate and a phenylene di(meth)acrylate in the presence of a porogen, wherein said copolymerisation is carried out at a temperature of at least 70° C. This polymer can be used as chromatographic material for separating biopolymers and small molecules.