ROTOR BLADE HAVING HEELS-OSCILLATING AND ROTOR OF GAS TURBINE ENGINE COMPRISING SUCH FINS.

HAUL-OFF YARN WITHIN THE STRAP OF THE UNDERWATER CATAPULT IN WHICH

COMBUSTION DEVICE LEAN FUEL INJECTION SYSTEM UPSTREAM OF THE NOZZLES

LIGHT TAG DEVICE, SYSTEM CONTAINER EQUIPPED WITH THE DEVICE AND METHOD OF MAKING SAME

Dispositif d'étiquette lumineuse, système de récipient équipé d'un tel dispositif et procédé de fabrication associé. L'invention concerne un dispositif d'étiquette lumineuse comprenant un support (1) réalisé majoritairement en un matériau conducteur de lumière, ledit support (1) comportant d'une part une face interne destinée à être apposée sur un récipient (3) et d'autre part une face externe (4) opposée, ledit dispositif comprenant une source lumineuse (5) agencée de manière à éclairer la tranche du support (1), et étant caractérisé en ce que le support (1) présente au moins une portion dont l'épaisseur est graduellement décroissante depuis une première section (7) de ladite portion jusqu'à une seconde section (8) opposée de ladite portion, et en ce que la source lumineuse (5) est agencée pour éclairer ladite première section (7) de façon à illuminer la face externe (4) par conduction de la lumière depuis la première section (7) vers la deuxième section (8). Dispositifs d'étiquettes lumineuses ...

FUEL REFORMEUR FOR DEVICE OF COMBUSTION OF ENGINE HAS GAS TURBINE AND PROCESS OF REFORMING

Reformeur (60) destiné à servir dans un moteur à turbine à gaz, comprenant un noyau (62) contenant une composition catalytique (65) et un canal d'entrée pour un mélange de combustibles, de l'air et de la vapeur. Un canal de sortie (66) transporte le courant de reformat, contenant des hydrocarbures reformés et ayant subi un craquage thermique et de grandes quantités d'hydrogène en vue d'une combinaison avec l'apport principal destiné au dispositif de combustion. La chaleur supplémentaire est transférée (et thermiquement intégrée) à l'aide d'un ou de plusieurs dispositifs d'échange de chaleur (72, 77) pour un premier et/ou un second courants auxiliaires de combustibles qui subissent un craquage thermique et une vaporisation avant de se combiner avec le reformat.

Supporting RMA API over active message

Procédés, appareils et logiciels pour mettre en œuvre des interfaces de programmation (API) de RMA par message actif (AM). Des demandes d'écriture AM et de lecture AM sont envoyées par un nœud local à un nœud distant pour écrire des données ou lire des données dans une mémoire sur le nœud distant en utilisant des techniques d'accès à la mémoire distante (RMA). Les demandes AM sont traitées par des gestionnaires AM correspondants qui effectuent automatiquement des opérations associées avec les demandes. Par exemple, pour les demandes d'écriture AM, un gestionnaire de demandes d'écriture AM peut écrire des données contenues dans une demande d'écriture AM dans un espace d'adresses distant situé dans la mémoire du nœud distant, ou générer une demande d'écriture RMA correspondante qui est mise dans une file d'attente RMA utilisée conformément à un système de messages marqués. Des opérations similaires sont effectuées par des gestionnaires de demandes de lecture AM. Les opérations de lecture ...

TURBOSHAFT ENGINE INCLUDING AN ELEMENT OF TUBE OF MIXTURE COMPRISING A VORTEX GENERATOR

Une turbomachine (2) comporte une section de compresseur (4), une chambre de combustion (8, 30, 47, 50) reliée fonctionnellement à la section de compresseur (4), un capot d'extrémité (10) monté sur la chambre de combustion (8, 30, 47, 50), et un ensemble de buses d'injection (20, 21, 22) reliées fonctionnellement à la chambre de combustion (8, 30, 47, 50). L'ensemble de buses d'injection (20, 21, 22) comporte une pluralité d'éléments de tube de mélange (100). Chaque élément de la pluralité d'éléments de tube de mélange (100) comporte une conduite (130) ayant une première entrée de fluide (132), une seconde entrée de fluide (134) agencée en aval de la première entrée de fluide (132), une extrémité d'évacuation (137) agencée en aval des première et seconde entrées de fluide (132, 134) et un générateur de tourbillons (144, 170, 184, 193, 194, 195, 220, 222) agencé entre les première et seconde entrées de fluide (132, 134). Le générateur de tourbillons (144, 170, 184, 193, 194, 195, 220, 222 ...

FUEL REFORMER FOR COMBUSTOR OF GAS TURBINE ENGINE AND METHOD OF REFORMING

TURBOMACHINE INCLUDING AN ELEMENT MIXING TUBE WITH VORTEX GENERATOR

LIGHT TAG DEVICE, SYSTEM CONTAINER EQUIPPED WITH THE DEVICE AND METHOD OF MAKING SAME

DEVICE OF COMBUSTION HAS SYSTEM Of LOW-GRADE FUEL INJECTION UPSTREAM OF the TUBES

Dispositif de combustion (100) pour brûler un flux de combustible et un flux d'air. Le dispositif de combustion (100) peut comprendre un certain nombre de buses (120) de combustible, un système d'injection (270) de combustible pauvre en amont des buses, placé en amont des buses (120) de combustible, et un volume annulaire de prémélange (250) placé entre les buses (120) de combustible et le système d'injection (270) de combustible pauvre en amont des buses, pour prémélanger le flux de combustible et le flux d'air.

COSMETIC COMPOSITION ANHYDROUS PIGMENTEE

ASSEMBLY TO COUPLE an ENGINE HAS GAS TURBINE HAS TURBO BLOWER ON UNESTRUCTURE Of PLANE

Generator comprises rotor structure having rotor frame supporting field turns and rectifier assembly, bus bar electrically connecting field turns to rectifier assembly, and grounding bushing electrically connecting bus bar to rotor frame

Un générateur (10) comprend une structure de rotor ayant un châssis de rotor qui supporte des enroulements de champ et un ensemble de redresseur. Le châssis de rotor comprend une ouverture (48) et une barre omnibus (42) passe à travers l'ouverture (48) et raccorde électriquement les enroulements de champ et l'ensemble de redresseur. Un manchon de mise à la terre (52) raccorde électriquement la barre omnibus au châssis de rotor.

Traction wire for underwater catapult, has set of connecting strands arranged at external abutment, where wire has sling traction function that allows only one mode of operation along entire length of barrel

Le fil tracteur à l'intérieur du sandow propulseur de la catapulte sous-marine à propulsion de la flèche sur la longueur du canon : PCT/FR/2004/001732 du 05/07/2004 est le montage d'un fil (a) lové dans le canal du sandow propulseur (b), figure 1 pour l'abrégé, ce fil sertis (d) aux extrémités du sandow propulseur (b) est allongé sur la flèche lors de son chargement, puis est mis sous haute tension (T) lors des chargements successifs des sandows tendeurs(g) sur les points d'appuis sous le fût de la catapulte. Ce système permet d'augmenter la tension (T) sur la flèche, en conséquence sa vitesse initiale, par rapport au même sandow (b) monté sans fil. De plus ce fil (a) résistant, souple, fin, mono filament ou non, gainé ou pas, sécurise le sandow propulseur d'une rupture et augmente sa longévité car le fil encaisse toute l'énergie des sandows tendeurs en bloquant l'extension du sandow propulseur et stocke toute l'énergie des sandows tendeurs, on a un meilleur rendement de la propulsion.

GROUNDING SLEEVE FOR ROTOR OF GENERATOR

INHIBITOR OF RETENTION OF FLAME FOR DIFFUSER Of FUEL INJECTION IN a GAS TURBINE

Inhibiteur (90) de rétention de flamme comportant une base (116) et un support dressé (107) s'écartant de la base ; au moins une languette (92) en forme d'aile delta sur le support dressé, chacune ayant une extrémité relativement pointue (96) et une extrémité relativement large (100).

Accelerator e.g. graphic card processor, designing method for e.g. civil industry, involves calculating costs for created aggregate accelerators from cost function, and selecting one of accelerators according to calculated cost

L'invention concerne un procédé pour la conception d'accélérateurs, dits accélérateurs agrégats, chacun d'eux étant adapté à au moins deux boucles (41,42) d'un programme, un accélérateur agrégat (12) comprenant des noeuds, correspondant à des éléments architecturaux (13,14,15,16,17), et des liens entre ces noeuds, ledit procédé de conception étant caractérisé en ce qu'il comporte les étapes suivantes : - la génération (31) d'accélérateurs spécialisés (43,44) adaptés auxdites boucles (41,42), - la création (32) d'au moins un accélérateur agrégat (45) à partir desdits accélérateurs spécialisés (43,44) et d'une base de données (49) d'éléments architecturaux prédéfinis (49.1), - le calcul (33) d'un coût pour chacun des accélérateurs agrégats (46) créés à partir d'une fonction de coût prédéfinie, - la sélection (34), en fonction du coût, d'un d'accélérateur agrégat parmi les accélérateurs créés.

USE OF the SULPHASALAZINE AND ITS METABOLITES FOR the MANUFACTURE Of a USEFUL DRUG IN the TREATMENT OF the VENOUS INSUFFICIENCY AND the VENOUS ULCERS

VOLATILE COMPOUNDS FOR THE TREATMENT OF [...]

THE TRIFUNCTIONAL CATALYTIC REDUCTION OF NOX IN DRY GAS TURBINE

CATALYTIC REDUCTION TRIFONCTIONNELLE DRY OF Nox Of a GAS TURBINE

VOLATILE COMPOUNDS FOR THE TREATMENT OF NEUROPALUDISME

LA PRESENTE INVENTION CONCERNE DES COMPOSES HALOGENE VOLATILS ANESTHESIQUES POUR LEUR UTILISATION DANS LE TRAITEMENT PREVENTIF ET CURATIF DES SYMPTOMES DU NEURO PALUDISME.

Fan e.g. centrifugal fan, for use in radiator of car, has obstacle for producing noise whose phase is opposite to that of selected tonal noise, where amplitude of obstacle noise is equal to that of tonal noise

Beverage brewing device

The beverage brewing device is configured for use with a beverage brewer having an inlet probe for dispensing water and an outlet probe. The beverage brewing device includes a body defining a brew chamber configured to contain a dry beverage medium and at least one outlet probe receptacle defined in the body and extending upwardly from a bottom surface of the body. The at least one outlet probe receptacle is sized and configured to receive an outlet probe of a beverage brewer. A lid is removably securable to the body and is engageable with the body to selectively enclose a top opening of the body. An inlet probe opening is defined in the lid for receiving an inlet probe of the beverage brewer. At least one filter is defined within in the body, wherein the filter is configured to retain a dry beverage medium within the brew chamber while allowing a brewed beverage to pass through the brew chamber.

Device features and design elements for long-term adhesion

An electronic device for long-term adhesion to a mammal includes a housing with an electronic component. The electronic device may include a first wing and a second wing, each being integrally formed with the housing. An electrode is positioned on a bottom surface of each of the wings, the electrodes electrically connected to the electronic component. An adhesive layer is provided for adhesion to a surface of the mammal. The adhesive layer may cover a portion of the bottom surfaces of the wings but generally does not cover the electrode or a bottom surface of the housing. A method of applying an electronic device to a mammal includes removing first and second adhesive covers from first and second wings of the electronic device to expose an electrode and an adhesive coated on a bottom surface of each wing.

Therapeutic heterocyclic compounds

Compounds having the following Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use and preparation are disclosed:

Marker-assisted selection of tolerance to chloride salt stress

Various methods and compositions are provided for identifying and/or selecting soybean plants or soybean germplasm with tolerance to chloride salt stress. In certain embodiments, the method comprises detecting at least one marker locus that is associated with tolerance to chloride salt stress. In other embodiments, the method further comprises detecting at least one marker profile or haplotype associated with chloride salt stress tolerance. In further embodiments, the method comprises crossing a selected soybean plant with a second soybean plant. Further provided are markers, primers, probes and kits useful for identifying and/or selecting soybean plants or soybean germplasm with tolerance to chloride salt stress.

Lip Seal

A seal includes an annular body defining a radial direction, an axial direction, and a circumferential direction; and further defines a cross-sectional area including a perimeter. The perimeter may comprise a first axial extremity, a second axial extremity, an outer radial extremity, and an inner radial extremity. The perimeter may include a first axial extremity defining surface and a second axial extremity defining surface, a first concave arcuate surface interposed between the inner radial extremity and the second axial extremity, and a second concave arcuate surface interposed between the outer radial extremity and the second axial extremity.

Lip Seal

A seal according to an embodiment of the present disclosure comprises an annular body defining a radial direction, an axial direction, and a circumferential direction; and further defining a cross-sectional area including a perimeter. The perimeter may comprise a first axial extremity, a second axial extremity, an outer radial extremity, and an inner radial extremity. The perimeter includes a first axially extending surface defining the outer radial extremity and an inner radial convex arcuate surface defining the inner radial extremity.

Physiological monitoring device

The present invention relates to a physiological monitoring device. Some embodiments of the invention allow for long-term monitoring of physiological signals. Further embodiments may also allow for the monitoring of secondary signals such as motion.

Substituted 6-azabenzimidazole compounds

The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

Glycerol 3- phosphate dehydrogenase for butanol production

Provided herein are glycerol-3-phosphate dehydrogenase (GPD) enzymes with increased K M for NADH and GPD enzymes with substantially the same affinity for NADH and NADPH and/or are feedback inhibited by glycerol-3-phosphate. Also provided herein are recombinant microorganisms comprising a heterologous gene encoding GPD and a deletion or disruption in an endogenous gene encoding GPD. Also provided are recombinant microorganisms comprising a heterologous gene encoding GPD and a butanol biosynthetic pathway. Further provided are methods of producing butanol comprising providing the recombinant microorganisms described herein and contacting the recombinant microorganism with at least one fermentable carbon substrate under conditions wherein butanol is produced.

Battery Disconnect Safeguard

In embodiments, a mobile device includes a primary battery as a power source to power components of the mobile device, and includes a secondary battery as an additional power source to power the components of the mobile device. A sensor is implemented to detect a free-fall of the device that indicates an impending secondary battery disconnect event due to the mobile device being dropped. A battery controller is implemented to receive a sensor input of the detected free-fall from the sensor. The battery controller can then switch from the secondary battery to the primary battery as the power source based on the detected free-fall of the mobile device. The battery controller can switch back from the primary battery to the secondary battery as the power source based on a lack of acceleration of the mobile device.

Systems and Methods for Detecting Threats and Contraband in Cargo

The present specification discloses systems and methods for identifying and reporting contents of a tanker, container or vehicle. Programmatic tools are provided to assist an operator in analyzing contents of a tanker, container or vehicle. Manifest data is automatically imported into the system for each shipment, thereby helping security personnel to quickly determine container contents. In case of a mismatch between container contents shown by manifest data and the contents as ascertained from the scanning system, the container or vehicle may be withheld for further inspection.

Variable flow adapters for air diffusers with damper

An air diffuser for a heating, ventilation, and/or air conditioning (HVAC) system includes a variable flow adapter including a plurality of nozzles and a damper. The variable flow adapter is configured to receive conditioned air from the HVAC system. The air diffuser also includes an actuator coupled to the damper and configured to actuate the damper between a first configuration and a second configuration. The damper is configured to block the conditioned air from passing therethrough and direct the conditioned air through the plurality of nozzles in the first configuration. Additionally, the damper is configured to open to direct the conditioned air therethrough in the second configuration.

Deactivation wipe kit and method of forming and using the same

A hazardous drug deactivation wipe kit includes a first pouch having a one-way valve coupled to an end thereof, a second pouch, and a third pouch. The first pouch contains a wipe saturated in a hypochlorite solution, the second pouch contains a wipe saturated in thiosulfate solution, and the third pouch contains a wipe saturated in isopropyl alcohol solution. The deactivation wipe kit may be used in a clean room to deactivate most hazardous drugs on a work surface.

Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes

Methods for the fermentative production of isobutanol is provided by the fermentative growth of a recombinant microorganism expressing a highly active ketol-acid reductoisomerase enzyme in addition to other enzymes required for conversion of glucose to isobutanol.

Ketol-acid reductoisomerase using nadh

Methods for the evolution of NADPH binding ketol-acid reductoisomerase enzymes to acquire NADH binding functionality are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to bind NADH are described.

Managing communications between robots and controllers

The present disclosure is directed to a system and method for managing communications with robots. In some implementations, a computer network, where operators interface with the network to control movement of robots on a wireless computer network includes a network arena controller and a plurality of robot controllers. The network arena controller is configured to provide firewall policies to substantially secure communication between robot controllers and the associated robots. Each controller is included in a different robot and configured to wirelessly communicate with the network arena controller. Each robot controller executes firewall policies to substantially secure wireless communication.

Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors

Provided herein are compounds of the General Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X 1 , X 2 , X 3 and X 4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including diseases or disorders mediated by a RET kinase.

Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors

Provided herein are compounds of the General Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X 1 , X 2 , X 3 and X 4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including diseases or disorders mediated by a RET kinase.

Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors

Provided herein are compounds of the General Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X 1 , X 2 , X 3 and X 4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including diseases or disorders mediated by a RET kinase.

Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors

Provided herein are compounds of the General Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X 1 , X 2 , X 3 and X 4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including diseases or disorders mediated by a RET kinase.

Membrane-based fluid control in microfluidic devices

A microfluidic device may include a substrate (410) that defines a flow-control cavity (420) and first (430) and second (440) channels in fluid communication with the flow-control cavity. A compliant membrane (450) for regulating fluid flow through the flow-control cavity may surround at least a portion of the flow-control cavity.

Absorbent article with stabilized absorbent structure having non-uniform lateral compression stiffness

An absorbent article having a liner adapted for contiguous relationship with the wearer's body, an outer cover in generally opposed relationship with the liner, and an absorbent body disposed between the liner and the outer cover. An absorbent structure of the absorbent body has a length, a thickness, a width, a longitudinal axis and a non-uniform lateral compression stiffness across its width. The non-uniform lateral compression stiffness is such that the absorbent structure assumes a pre-determined, or non-random buckled configuration under lateral compression thereof. In one embodiment, the buckled configuration is generally symmetric about a plane normal to the absorbent structure and in which the longitudinal axis of the absorbent structure lies.

Dry cell construction having a one piece plastic closure

A dry cell construction having a one-piece plastic closure covering the open end of the negative electrode can which contains a depolarizer mix and a current collector centrally imbedded in the depolarizer mix. The plastic closure rests on the top edge of the negative electrode can and has a tubular projection extending from the bottom thereof through which the current collector passes. The tubular projection covers the current collector throughout an airspace located above the depolarizer mix. The plastic closure contains at least one venthole extending from its top surface into contact with the airspace above the depolarizer mix and at least one groove in the top surface of the closure extending from the outer edge of the closure into contact with the airspace between the terminal cap on top of the current collector and the plastic closure. It is preferred that the plastic closure have a plurality of ventholes and grooves which are offset from each other. The cell construction of this invention is particularly adapted for rechargeable dry cells which utilize a depolarizer mix containing an azodicarbonamide depolarizer material.

Deep water drilling with casing

Methods and apparatus are provided to place a conductor pipe and a casing in a subsea environment. In one embodiment, a conductor pipe is jetted or drilled into the subsea floor. Thereafter, a casing drilling assembly comprising a drill casing and a drilling assembly is connected to the drill pipe using a crossover. The drilling assembly urged into the seafloor until a casing latch on the drilling assembly is engaged with a casing profile of the conductor pipe. During drilling, instrumentation in the drilling assembly may be used to measure geophysical data. The measured data may be used to optimize the drilling process. After the drill casing is engaged with the conductor pipe, cementing may be performed to set the drill casing.

Deep water drilling with casing

Methods and apparatus are provided to place a conductor pipe and a casing in a subsea environment. In one embodiment, a conductor pipe is jetted or drilled into the subsea floor. Thereafter, a casing drilling assembly comprising a drill casing and a drilling assembly is connected to the drill pipe using a crossover. The drilling assembly urged into the seafloor until a casing latch on the drilling assembly is engaged with a casing profile of the conductor pipe. During drilling, instrumentation in the drilling assembly may be used to measure geophysical data. The measured data may be used to optimize the drilling process. After the drill casing is engaged with the conductor pipe, cementing may be performed to set the drill casing.

Method for sensing analyte in test liquid through coagulation, reagent kit, synthetic particle carrying fixed ligand molecule, and use of the particle

(57)【要約】 【課題】 凝集により試験液中の分析物を検出するため の方法及び試薬キット、固定リガンド分子を担持する合 成粒子並びにその使用 【解決手段】 本発明は、試験液を凝集試薬及び不活性 マトリックスと接触させ、反応混合物に重力を作用さ せ、分析物と凝集試薬との反応を検定する、凝集により 試験液中の分析物を検出する方法に関し、該方法では、 凝集試薬として合成粒子を使用し、該粒子がマトリック スに対して実質的に赤血球のように挙動するように該粒 子の直径及び密度を選択する。更に、表面上にリガンド 分子が吸着されている新規の合成粒子及び検出試薬とし ての該粒子の使用を開示する。

Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes

Methods for the fermentative production of isobutanol is provided by the fermentative growth of a recombinant microorganism expressing a highly active ketol-acid reductoisomerase enzyme in addition to other enzymes required for conversion of glucose to isobutanol.

Ketol-acid reductoisomerase using NADH

Methods for the evolution of NADPH binding ketol-acid reductoisomerase enzymes to acquire NADH binding functionality are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to bind NADH are described.

Ketol-acid reductoisomerase using NADH

Methods for the evolution of NADPH specific ketol-add reductoisomerase enzymes to acquire NADH specificity are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to utilize NADH are described.

Host cells and methods for production of isobutanol

Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.

Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes

Methods for the fermentative production of isobutanol is provided by the fermentative growth of a recombinant microorganism expressing a highly active ketol-acid reductoisomerase enzyme in addition to other enzymes required for conversion of glucose to isobutanol.

Ketol-acid reductoisomerase using NADH

Methods for the evolution of NADPH binding ketol-acid reductoisomerase enzymes to acquire NADH binding functionality are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to bind NADH are described.

Ketol-acid reductoisomerase using NADH

Methods for the evolution of NADPH specific ketol-acid reductoisomerase enzymes to acquire NADH specificity are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to utilize NADH are described.

Ketol-acid reductoisomerase using NADH

Methods for the evolution of NADPH binding ketol-acid reductoisomerase enzymes to acquire NADH binding functionality are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to bind NADH are described.

Ketol-acid reductoisomerase using NADH

Methods for the evolution of NADPH specific ketol-acid reductoisomerase enzymes to acquire NADH specificity are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to utilize NADH are described.

Ketol-acid reductoisomerase using NADH

Methods for the evolution of NADPH binding ketol-acid reductoisomerase enzymes to acquire NADH binding functionality are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to bind NADH are described.

Host cells and methods for production of isobutanol

Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.

Host cells and methods for production of isobutanol

Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.

Force feedback system

A system and method for providing a tactile virtual reality to a user is present. The position and orientation of the user is utilized to generate a virtual reality force field. Forces are in turn generated on the user as a function of this force field. A six-axis manipulator is presented for providing a user interface to such a system. This manipulator provides a unique kinematic structure with two constant force springs which provide gravity compensation so that the manipulator effectively floats.

Ketol-acid reductoisomerase using nadh

Methods for the evolution of NADPH specific ketol-acid reductoisomerase enzymes to acquire NADH specificity are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to utilize NADH are described.

Improved yeast production host cells

Crabtree positive yeast cells that have endogenous expressed pyruvate decarboxylase genes inactivated and an engineered biosynthetic pathway utilizing pyruvate were found to have improved growth and product yield when glucose repression was reduced. These cells were able to grow in media containing a high glucose concentration.

Host cells and methods for production of isobutanol

Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.

Glycerol 3- phosphate dehydrogenase for butanol production

Provided herein are glycerol-3 -phosphate dehydrogenase (GPD) enzymes with increased K M for NADH and GPD enzymes with substantially the same affinity for NADH and NADPH and/or are feedback inhibited by glycerol-3-phosphate. Also provided herein are recombinant microorganisms comprising a heterologous gene encoding GPD and a deletion or disruption in an endogenous gene encoding GPD. Also provided are recombinant microorganisms comprising a heterologous gene encoding GPD and a butanol biosynthetic pathway. Further provided are methods of producing butanol comprising providing the recombinant microorganisms described herein and contacting the recombinant microorganism with at least one fermentable carbon substrate under conditions wherein butanol is produced.

Cetol-acid reductoisomerase using NADH

Una enzima cetol-ácido reductoisomerasa como se expone en la ID de SEC Nº: 17, en la que a) el resto 52 se muta; o b) los restos 47, 50 y 52 se mutan; o c) el resto 52 y al menos un resto seleccionado del grupo que consiste en 24, 33, 53, 61, 80, 115, 156, 165 y 170 se mutan; o d) los restos 47, 50, 52 y al menos un resto seleccionado del grupo que consiste en 24, 33, 53, 61, 80, 115, 156, 165 y 170 se mutan; y en la que dicha enzima cetol-ácido reductoisomerasa en el que dicha enzima cetol-ácido reductoisomerasa tiene una preferencia por la unión NADH en lugar de por NADPH, y en donde dicha mutación es una sustitución de aminoácidos. A ketol acid reductoisomerase enzyme as set forth in SEQ ID NO: 17, in which a) moiety 52 is mutated; or b) residues 47, 50 and 52 are mutated; or c) the remainder 52 and at least one remainder selected from the group consisting of 24, 33, 53, 61, 80, 115, 156, 165 and 170 are mutated; or d) residues 47, 50, 52 and at least one remainder selected from the group consisting of 24, 33, 53, 61, 80, 115, 156, 165 and 170 are mutated; and wherein said cetol acid reductoisomerase enzyme in which said cetol acid reductoisomerase enzyme has a preference for NADH binding rather than NADPH, and wherein said mutation is an amino acid substitution.

Yeast production host cells

Crabtree positive yeast cells that have endogenous expressed pyruvate decarboxylase genes inactivated and an engineered biosynthetic pathway utilizing pyruvate were found to have improved growth and product yield when glucose repression was reduced. These cells were able to grow in media containing a high glucose concentration.

Yeast production host cells

Crabtree positive yeast cells that have endogenous expressed pyruvate decarboxylase genes inactivated and an engineered biosynthetic pathway utilizing pyruvate were found to have improved growth and product yield when glucose repression was reduced. These cells were able to grow in media containing a high glucose concentration.

Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes

Methods for the fermentative production of isobutanol is provided by the fermentative growth of a recombinant microorganism expressing a highly active ketol-acid reductoisomerase enzyme in addition to other enzymes required for conversion of glucose to isobutanol.

Glycerol 3-phosphate dehydrogenase for butanol production

Provided herein are glycerol-3-phosphate dehydrogenase (GPD) enzymes with increased K M for NADH and GPD enzymes with substantially the same affinity for NADH and NADPH and/or are feedback inhibited by glycerol-3-phosphate. Also provided herein are recombinant microorganisms comprising a heterologous gene encoding GPD and a deletion or disruption in an endogenous gene encoding GPD. Also provided are recombinant microorganisms comprising a heterologous gene encoding GPD and a butanol biosynthetic pathway. Further provided are methods of producing butanol comprising providing the recombinant microorganisms described herein and contacting the recombinant microorganism with at least one fermentable carbon substrate under conditions wherein butanol is produced.

Ketol-acid reductoisomerase using nadh

Improved yeast production host cells

Crabtree positive yeast cells that have endogenous expressed pyruvate decarboxylase genes inactivated and an engineered biosynthetic pathway utilizing pyruvate were found to have improved growth and product yield when glucose repression was reduced. These cells were able to grow in media containing a high glucose concentration.

Glycerol 3- phosphate dehydrogenase for butanol production

Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes

Methods for the fermentative production of isobutanol is provided by the fermentative growth of a recombinant microorganism expressing a highly active ketol-acid reductoisomerase enzyme in addition to other enzymes required for conversion of glucose to isobutanol.

Fermentation production of isobutanol using highly active cetol-acid reductoisomerase enzymes

Un método para la conversión de acetolactato a dihidroxiisovalerato, que comprende: a) proporcionar una célula hospedante microbiana que comprende una construcción genética que codifica unpolipéptido que tienen una actividad específica de cetol-ácido reductoisomerasa mayor que la actividad específica deuna cetol-ácido reductoisomerasa de E. coli, en el que dicho polipéptido tiene una actividad específica de cetol-ácidoreductoisomerasa mayor que 1,1 μmoles/min/mg basada en la proteína purificada, medida mediante el ensayo deconsumo de NADPH, ejecutado bajo las siguientes condiciones: i) pH de aproximadamente 7,5; ii) una temperatura de aproximadamente 22,5 ºC; y iii) potasio mayor que aproximadamente 10 mM; y b) poner en contacto la célula hospedante de a) con acetolactato, en el que se produce 2,3-dihidroxiisovalerato. A method for the conversion of acetolactate to dihydroxyisovalerate, comprising: a) providing a microbial host cell comprising a genetic construct encoding a polypeptide having a specific activity of cetol-acid reductoisomerase greater than the specific activity of a ketol-acid reductoisomerase E coli, in which said polypeptide has a specific activity of cetol-acid-reductoisomerase greater than 1.1 μmol / min / mg based on the purified protein, measured by the NADPH consumption test, executed under the following conditions: i) pH of about 7.5; ii) a temperature of approximately 22.5 ° C; and iii) potassium greater than about 10 mM; and b) contacting the host cell of a) with acetolactate, in which 2,3-dihydroxyisovalerate is produced.

Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes

Methods for the fermentative production of isobutanol is provided by the fermentative growth of a recombinant microorganism expressing a highly active ketol-acid reductoisomerase enzyme in addition to other enzymes required for conversion of glucose to isobutanol.

Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes

Host cells and methods for production of isobutanol

Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.

Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes

Methods for the fermentative production of isobutanol is provided by the fermentative growth of a recombinant microorganism expressing a highly activ e ketol-acid reductoisomerase enzyme in addition to other enzymes required f or conversion of glucose to isobutanol.

Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes

Methods for the fermentative production of isobutanol is provided by the fermentative growth of a recombinant microorganism expressing a highly active ketol-acid reductoisomerase enzyme in addition to other enzymes required for conversion of glucose to isobutanol.

Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes

Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes

Methods for the fermentative production of isobutanol is provided by the fermentative growth of a recombinant microorganism expressing a highly active ketol-acid reductoisomerase enzyme in addition to other enzymes required for conversion of glucose to isobutanol.

Ketol-acid reductoisomerase using NADH

Increasing activity of 2' fucosyllactose transporters endogenous to microbial cells

A fermentation broth which includes a microbial cell which has been subjected to a condition under which the activity an endogenous transporter for 2' fucosyllactose is increased. Also provided are methods for increasing export of 2' fucosyllactose from a microbial cell, methods for identifying an endogenous yeast transporter of 2' fucosyllactose, and microbial cells genetically engineered to increase the activity of an endogenous transporter of 2' fucosyllactose.

Ketol-acid reductoisomerase using nadh

Methods for the evolution of NADPH binding ketol-acid reductoisomerase enzymes to acquire NADH binding functionality are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to bind NADH are described.

Ketol-acid reductoisomerase using nadh

Methods for the evolution of NADPH binding ketol-acid reductoisomerase enzymes to acquire NADH binding functionality are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to bind NADH are described.

Cetol-acid reductoisomerase using NADH

Una enzima cetol-ácido reductoisomerasa como se expone en la ID de SEC Nº: 17 que comprende mutaciones en los restos 47, 50, 52 y 53, que opcionalmente comprende además al menos una mutación en un resto seleccionado del grupo que consiste en 24, 33, 61, 80, 115, 156, 165 y 170, en el que dicha enzima cetol-ácido reductoisomerasa tiene una preferencia por la unión NADH en lugar de por NADPH, y en donde dicha enzima cetol-ácido reductoisomerasa es una enzima cetol-ácido reductoisomerasa de clase I. A ketol acid reductoisomerase enzyme as set forth in SEQ ID NO: 17 which comprises mutations in residues 47, 50, 52 and 53, which optionally further comprises at least one mutation in a moiety selected from the group consisting of 24, 33, 61, 80, 115, 156, 165 and 170, wherein said cetol-acid reductoisomerase enzyme has a preference for NADH binding rather than NADPH, and wherein said cetol-acid reductoisomerase enzyme is a cetol-enzyme Class I reductoisomerase acid.

Host cells and methods for production of isobutanol

Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.

Ketol-acid reductoisomerase using nadh

Methods for the evolution of NADPH binding ketol-acid reductoisomerase enzymes to acquire NADH binding functionality are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to bind NADH are described.

Ketol-acid reductoisomerase using nadh

Methods for the evolution of NADPH binding ketol-acid reductoisomerase enzymes to acquire NADH binding functionality are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to bind NADH are described.

Unified access control system

An amusement park access control system includes an amusement park area having an entrance. A unified access control device is positioned at the entrance and is configured to control guest access into the amusement park area. The unified access control device includes sensor modules and an access control module physically connected to one another to form a unified structure. The sensor modules scan the entrance to determine guest identification data. An access control computer system is communicatively coupled to the unified access control device and includes databases storing guest enrollment data and entitlement data associated with the guest enrollment data. The unified access control device identifies entitlements associated with the guest identification data based on a comparison between the guest identification data, the guest enrollment data, and the entitlement data, and controls guest access through the entrance based on the identified entitlements.

Force feedback system

A system and method for providing a tactile virtual reality to a user is present. The position and orientation of the user is utilized to generate a virtual reality force field. Forces are in turn generated on the user as a function of this force field. A six-axis manipulator is presented for providing a user interface to such a system. This manipulator provides a unique kinematic structure with two constant force springs which provide gravity compensation so that the manipulator effectively floats.

Force feedback system and actuator power management

A system and method for providing a tactile virtual reality to a user is present. The position and orientation of the user is utilized to generate a virtual reality force field. Forces are in turn generated on the user as a function of this force field. A six-axis manipulator is presented for providing a user interface to such a system. This manipulator provides a unique kinematic structure with two constant force springs, which provide gravity compensation so that the manipulator effectively floats.

Substituted spirocydic inhibitors of autotaxin

Stem canker tolerant soybeans and methods of use

Soybean plants, germplasm and seed comprising at least one native locus conferring improved stem canker tolerance, molecular markers useful for identifying and, optionally, selecting soybean plants displaying tolerance, improved tolerance, or susceptibility to stem canker, and methods of their use are provided. Also provided are isolated polynucleotides, probes, kits, systems, and the like, useful for carrying out the methods described herein. The QTL for stem canker tolerance is located on chromosome 14 (linkage group B2).

Physiological monitoring device

The present invention relates to a physiological monitoring device. Some embodiments of the invention allow for long-term monitoring of physiological signals. Further embodiments may also allow for the monitoring of secondary signals such as motion.

Device features and design elements for long-term adhesion

An electronic device for long-term adhesion to a mammal includes a housing with an electronic component. The electronic device may include a first wing and a second wing, each being integrally formed with the housing. An electrode is positioned on a bottom surface of each of the wings, the electrodes electrically connected to the electronic component. An adhesive layer is provided for adhesion to a surface of the mammal. The adhesive layer may cover a portion of the bottom surfaces of the wings but generally does not cover the electrode or a bottom surface of the housing. A method of applying an electronic device to a mammal includes removing first and second adhesive covers from first and second wings of the electronic device to expose an electrode and an adhesive coated on a bottom surface of each wing.

Device features and design elements for long-term adhesion

An electronic device for long-term adhesion to a mammal includes a housing with an electronic component. The electronic device may include a first wing and a second wing, each being integrally formed with the housing. An electrode is positioned on a bottom surface of each of the wings, the electrodes electrically connected to the electronic component. An adhesive layer is provided for adhesion to a surface of the mammal. The adhesive layer may cover a portion of the bottom surfaces of the wings but generally does not cover the electrode or a bottom surface of the housing. A method of applying an electronic device to a mammal includes removing first and second adhesive covers from first and second wings of the electronic device to expose an electrode and an adhesive coated on a bottom surface of each wing.

Device features and design elements for long-term adhesion

An electronic device for long-term adhesion to a mammal includes a housing with an electronic component. The electronic device may include a first wing and a second wing, each being integrally formed with the housing. An electrode is positioned on a bottom surface of each of the wings, the electrodes electrically connected to the electronic component. An adhesive layer is provided for adhesion to a surface of the mammal. The adhesive layer may cover a portion of the bottom surfaces of the wings but generally does not cover the electrode or a bottom surface of the housing. A method of applying an electronic device to a mammal includes removing first and second adhesive covers from first and second wings of the electronic device to expose an electrode and an adhesive coated on a bottom surface of each wing.

Physiological monitoring device

The present invention relates to a physiological monitoring device. Some embodiments of the invention allow for long-term monitoring of physiological signals. Further embodiments may also allow for the monitoring of secondary signals such as motion.

Physiological monitoring device

The present invention relates to a physiological monitoring device. Some embodiments of the invention allow for long-term monitoring of physiological signals. Further embodiments may also allow for the monitoring of secondary signals such as motion.

Wearable monitor

The present disclosure relates to a wearable monitor device and methods and systems for using such a device. In certain embodiments, the wearable monitor records cardiac data from a mammal and extracts particular features of interest. These features are then transmitted and used to provide health-related information about the mammal.

Wearable monitor

The present disclosure relates to a wearable monitor device and methods and systems for using such a device. In certain embodiments, the wearable monitor records cardiac data from a mammal and extracts particular features of interest. These features are then transmitted and used to provide health-related information about the mammal.

Expression of biologically active PDGF analogs in eucaryotic cells

Methods for expressing a variety of biologically active PDGF analogs in eucaryotic cells are disclosed. The methods generally comprise introducing into a eucaryotic host cell a DNA construct capable of directing the expression and secretion of biologically active PDGF analogs in eucaryotic cells. The DNA construct contains a transcriptional promoter followed downstream by a suitable DNA sequence. The DNA sequence may encode a protein substantially homologous to the A-chain or the B-chain of PDGF, or a portion thereof, or an A-B heterodimer. In addition, a portion of the DNA sequence may encode at least a portion of the A-chain, while another portion encodes at least a portion of the B-chain of PDGF. Eucaryotic cells transformed with these DNA constructs are also disclosed. Methods of promoting the growth of mammalian cells, comprising incubating the cells with a biologically active PDGF analog expressed by a eucaryotic host cell transformed with such a DNA construct, are also disclosed.

Incorporation of apertured area into an absorbent article

An absorbent article having improved handling of body exudates. The absorbent article can minimize the amount of body exudates in contact with a wearer's skin and can minimize the incidence of leakage of body exudates from the absorbent article. The benefits of the absorbent article are achieved, in part, by a body facing material having features that help minimize contact of body exudates with the wearer's skin while also being constructed so that the body facing material does not stick to the wearer's skin in use. The body facing material includes a plurality of hollow projections, a plurality of apertures and bonded areas. The bonded areas may be formed with adhesive or by mechanical bonds.

Expression of factor VII activity in mammalian cells

Methods are disclosed for producing proteins having biological activity for blood coagulation mediated by Factor VIIa. The proteins are produced by mammalian host cells which have been stably transfected with a DNA construct containing a nucleotide sequence which codes at least partially for either Factor VII. The nucleotide sequence comprises a first nucleotide sequence encoding a calcium binding domain, joined to a second nucleotide sequence positioned downstream of the first sequence. In particular, the first nucleotide sequence may be derived from a genomic clone or cDNA clone of Factor VII. The second sequence encodes a catalytic domain for the serine protease activity of Factor VIIA. The joined sequences code for proteins having substantially the same biological activity for blood coagulation as Factor VIIa.

Absorbent article with stabilized absorbent structure

System for controlling the distribution and use of digital works using secure components

A system for controlling the distribution and use of digital works using digital tickets. In the present invention, a “digital ticket” is used to entitle the ticket holder to exercise some usage right with respect to a digital work. Usage rights are used to define how a digital work may be used or distributed. Each usage right may specify a digital ticket which must be present before the right may be exercised. Digital works are stored in repositories which enforce a digital works usage rights. Each repository has a “generic ticket agent” which punches tickets. In some instances only the generic ticket agent is necessary. In other instances, punching by a “special ticket agent” residing on another repository may be needed.

Enhanced remote controls for robots

This disclosure relates to enhanced control of user configurable devices, such as robots. One system may include a user-configurable device and an on-vehicle programmable controller coupled to the user-configurable device. This system may further include a wireless receiver coupled to the on-vehicle programmable controller via one signal wire, where a substantial portion of the receiver-controlled communications occur using the one signal wire. Another system may include (alternatively or in combination as appropriate) a user-configurable device including an on-vehicle programmable controller and a first tether port. The system may also include a remote control transmitter with at least one wireless output and a second tether port, where the transmitter is communicably coupled to the user-configurable remote control device.

Method and apparatus for liquefying natural gas stream

【課題】天然ガス流を液化する装置及び方法を提供すること。 【解決手段】該方法は、液化のための脱水された天然ガス流を供給する工程、該脱水された天然ガス流を予冷装置で予冷する工程であって、該予冷をハイドロフルオロカーボン（ＨＦＣ）冷媒から本質的になる予冷冷却剤を用いて行う予冷工程、該予冷された脱水された天然ガス流を主熱交換器において気化される炭化水素混合冷媒冷却剤との間接的熱交換によって更に冷却して液化した天然ガス製品流を製造する工程を含み、該混合冷媒冷却剤はエタン、メタン、窒素、及び３モル％以下のプロパンを含む。 【選択図】図１

Substituted 6-azabenzimidazole compounds having HPK1 inhibitory activity

The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

Fabrics with v-guides

A fabric having one or more guides attached to a wear surface of the fabric so to encapsulate fifty percent or more of the fabric caliper. Advantageously, the encapsulation of the fabric by the guide, and not the chemical affinity of the materials, is the mechanism that attaches the guide and fabric. Consequently, the bond strength is equal to the tear strength of either the fabric.

TRIP DEVICE FOR INTERRUPTION DEVICE WITH IMMEDIATE CIRCUIT PROTECTION AND SWITCH PROVIDED WITH SUCH TRIP DEVICE

The idea behind this algorithm is to provide prioritized data in an optimal sequence to expedite initialization/activation of ordered processes necessary to effect circuit protection functionality from a circuit breaker trip unit.

An improved method for extracting cocoa procyanidins

A cocoa extract which is rich in procyanidin oligomers is made by extracting defatted cocoa beans with solvents or aqueous solvents which solubilize the procyanidins. The yield of procyanidins in an extract varies with the cocoa beans used, the solvent used, the pH of the solvent used and the extraction temperature. Extraction parameters can be optimized to increase procyanidin yield and to allow for the preferential extraction of higher or lower molecular weight oligomers. A preferred extraction method is a counter-current solvent extraction process in which the cocoa extract is recycled.

Systems and methods for detecting threats and contraband in cargo

Novel chimeric tnf ligands

The present invention is directed to an isolated polynucleotide sequence encoding a chimeric TNFα, comprising a first nucleotide sequence encoding a domain or subdomain of a tumor necrosis factor ligand other than TNFα, wherein the encoded domain or subdomain replaces a cleavage site of native TNFα, and a second nucleotide sequence encoding a domain or subdomain of native TNFα that binds to a TNFα receptor. The encoded chimeric TNFα is significantly less susceptible to cleavage from the cellular surface and, as a result can increase the concentration of a ligand capable of binding to a TNFα receptor on the surface of a cell. The chimeric TNFα is therefore useful in methods for inducing apoptosis of a cell expressing a TNFα receptor, inducing activation of an immune system cell and treating neoplastic cells, by introducing into the cell of interest an isolated polynucleotide sequence encoding a chimeric TNFα that is expressed on the surface of the cell.

System and method for providing topic-guided broadening of advertising targets in social indexing

A computer-implemented system and method for providing topic-guided broadening of advertising targets in social indexing is provided. Articles of digital information and one or more social indexes (11) are maintained. Each social index includes topics that each relate to one or more of the articles. A Web page, which includes one or more of the articles, is identified. The one or more topics in at least one of the social indexes related to the one or more articles are determined (42). A plurality of advertising expressions that are each associated with advertising content for an online advertiser are received (43). Each of the advertising expressions is successively matched (44) to the one or more topics related to the one or more articles followed by matching words descriptive of the one or more topics.

Time variable incentive for purchasing goods and services

An apparatus and method for motivating a consumer to promptly indicate an interest in purchasing a product and/or service over a computer network includes the steps of presenting an offer for sale of a product and/or service to the consumer over the computer network (S1), concurrently presenting an incentive for purchasing the product and/or service to the consumer promptly over the computer network. The incentive is initially set to a predetermined maximum value (S2) and decreases over a period of time (S3). Additional steps include indicating an interest to purchase the product and/or service by the consumer at a point in time during the period of time (S5), and providing the consumer the current value of the incentive corresponding to the point in time at which the consumer indicated the interest (S7).

Therapeutic heterocyclic compounds

Compounds having the following Formula (I), or a pharmaceutically acceptable salt or pharmaceutically acceptable tautomer thereof, and methods of their use and preparation are disclosed: Formula (I)

Beverage brewing device

The beverage brewing device, which is configured for use with a beverage brewer having an inlet probe for dispensing water and an outlet probe, includes a body defining a brew chamber configured to contain a dry beverage medium and at least one outlet probe receptacle extending upwardly from a bottom surface of the body. The outlet probe receptacle is sized and configured to receive an outlet probe of a beverage brewer. A lid is removably securable to the body and is engageable with the body to selectively enclose a top opening of the body. An inlet probe opening is defined in the lid for receiving an inlet probe of the beverage brewer. At least one filter is defined within the body, wherein the filter is configured to retain a dry beverage medium within the brew chamber while allowing a brewed beverage to pass through the brew chamber.

Seal assembly for track pin joint assembly

A seal assembly can be incorporated into a track pin joint assembly including a pin defining a longitudinal axis, a first member and a second member both coaxial with the pin about the longitudinal axis. The first member is pivotable about the longitudinal axis with respect to the second member and includes a load ring engagement surface defining, at least in part, an axially- extending seal cavity disposed in proximal relationship to the second member. A seal assembly including a seal ring and a load ring is disposed in the seal cavity and sealingly engages the first member and the second member. At least one of a load ring engagement surface of the first member and an axial segment of a first member engagement surface of the load ring includes a convex rounded portion extending over at least half the axial length thereof.

High permeability texturing belt

The instant invention relates to an industrial fabric for producing a textured product, wherein the industrial fabric has a first layer, such as a woven base fabric, and a second layer, such as a film, that extends over at least a portion of a top surface of the first layer. The second layer has macro voids and micro voids. In certain embodiments, the macro voids impart a texture in a fiber product produced on the industrial fabric, whereas the micro voids limit or prevent penetration of the fibers of the product into the micro voids while at the same time increasing permeability of the industrial fabric.