Bioresorbable and biocompatible compounds for surgical use

A bioresorbable and biocompatible compound for surgical use is composed of functionalized collagen cross-linked with a glycosaminoglycan.

Tissue engineering support

Cell cultures or tissue engineering supports, include at least a porous matrix based on a collagen sponge which defines first pores and a porous three-dimensional knit which defines second pores, the porous matrix filling the three-dimensional knit and all the first and second pores being at least partially interconnected with one another.

BIORESORBABLE AND BIOCOMPATIBLE COMPOUNDS FOR SURGICAL USE

A bioresorbable and biocompatible compound for surgical use is composed of functionalized collagen cross-linked with a glycosaminoglycan. 1. A compound comprising a functionalized collagen covalently bonded directly to a glycosaminoglycan without the use of a crosslinking agent , wherein the glycosaminoglycan is chitosan and wherein the collagen is functionalized by oxidative cleavage.2. A compound as in wherein the functionalized collagen includes one or more reactive moieties selected from the group consisting of aldehydes claim 1 , sulfones claim 1 , vinylsulfones claim 1 , isocyanates claim 1 , and acid anhydrides.3. The compound of wherein the functionalized collagen includes one or more reactive moieties selected from the group consisting of —CON(COCH) claim 1 , —CON(COCH) claim 1 , —COH claim 1 , —CHO claim 1 , —CHOCH claim 1 , —N═C═O claim 1 , —SOCH═H claim 1 , —N(COCH) claim 1 , and —S—S—(CHN).4. A compound of wherein the glycosaminoglycan includes a blend of chitosan with different degree of acetylation selected from about 0.5 to 60%.5. An implant comprising a compound containing a functionalized collagen covalently bonded directly to a glycosaminoglycan without the use of a crosslinking agent claim 1 , wherein the glycosaminoglycan is chitosan and wherein the collagen is functionalized by oxidative cleavage.6. The implant of comprising a sponge containing said compound.7. The implant of comprising a textile containing said compound.8. The implant of comprising a hydrogel containing said compound.9. The implant of comprising threads containing said compound.10. The implant of comprising a non knitted claim 5 , non woven composite containing said compound.11. The implant of comprising a film containing said compound.12. The implant of comprising a mesh coated with a composition containing said compound.13. A method of forming a bioresorbable compound comprising contacting a functionalized collagen with a glycosaminoglycan without the use of a crosslinking ...

Instrument for storing and dispensing a surgical fastener

The device, designed to be fixed to the distal end of a fastener-positioning instrument, comprises a plane transverse distal end, a split first longitudinal channel and a second longitudinal channel, in which channels the anchoring bar and the stop bar of a fastener can slide, respectively. The device has a longitudinal bearing face that defines a half-space. The device further includes: a cam forming a stop/sliding surface for the distal end of the stop bar, in order to produce a pivoting movement of the stop bar; cams for the lateral splaying of the proximal part of the stop bar; and an escapement cam, allowing the lateral displacement of the distal part of the stop bar and its disengagement from the first cam.

Mesh implant

A mesh implant is disclosed which may be utilized for treating urinary incontinence, hernias, uterovaginal prolapses and other related injuries.

Compounds and medical devices activated with solvophobic linkers

The present disclosure relates to compounds and medical devices activated with a solvophobic material functionalized with a first reactive member and methods of making such compounds and devices.

Medical device with degradation-retarding coating

The present disclosure relates to implantable bioabsorbable medical devices having an amphiphilic coating for delaying the degradation of the device and methods of making such devices.

Guide for selecting and positioning a prosthesis

The invention relates to a device (1) and method for selecting the size and shape of a prosthesis and/or for determining the location of marks to be made on the external face of the skin of a patient intended to receive such a prosthesis, for example for repairing a hernia, comprising a sheet (2) of transparent material, the said sheet comprising: —a plurality of graphical representations (3a, 3b, 4a, 4b, 5a, 5b, 5c, 5d) concentrically embodying the respective outlines of various shapes and sizes of prosthesis, —a plurality of first holes (6a, 6b, 6c, 6d, 6e, 7a, 7b, 7c, 7d, 7e) arranged along the transverse line passing through the centre of the said sheet, and —a plurality of second holes (8a, 8b, 8c, 8d, 8e, 8f, 8g, 9a, 9b, 9c, 9d, 9e, 9f, 9g) arranged along the longitudinal line passing through the centre (C) of the said sheet.

Assessment of Shear Forces Distribution at Fixation Points of Textile Based Implants

A system for assessing the distribution of shear forces at fixation points on a textile-based implant includes a tissue model, a load simulation device, and an analysis system. The tissue model includes an upper surface defining an opening therethrough and a fixation support configured to secure a textile-based implant against the upper surface at a plurality of fixation points defined along a plane of the upper surface. The load simulation device is configured to apply a load to a textile-based implant that is secured to the tissue model. A marker is disposed on the fixation support at one or more of the plurality of fixation points. The analysis system is configured to calculate a shear force vector at each of the fixation points where a marker is disposed in response to the load applied by the load simulation device.

Biosynthetic implant for soft tissue repair

An implant and a process for preparing such an implant are disclosed. The implant includes a porous layer including collagen, a non-porous layer including a collagenic constituent, and a reinforcement component. The non-porous layer is joined to the porous layer and the reinforcement member is embedded into the non-porous layer. The porous layer has a three dimensional density ranging from about 20 mg collagen/cm 3 to about 200 mg collagen/cm 3 .

Bioresorbable knit for hernia repair and method for manufacturing the same

The present invention relates to a bioresorbable prosthetic porous knit comprising an arrangement of yarns of bioresorbable biocompatible material defining at least two sides for said knit, said knit being provided, on one of its sides, with barbs protruding outwards from said one side, wherein each yarn of the arrangement defining said two sides is doubled. The invention further relates to a method for manufacturing such a knit.

Surgical drain

In a surgical drain system formed with two or more branches, exudate flow from a patient's wound is directed between two branches with the respective filling and emptying times determined in order to identify the presence of a blockage in the drain.

Surgical fasteners and methods for sealing wounds

A method for closing a wound in tissue is provided which includes providing a surgical fastener having a plurality of reactive members of a specific binding pair attached on a surface of the surgical fastener, and providing tissue with a plurality of complementary reactive members of the specific binding pair, wherein upon contact of the reactive members on the surface of the surgical fastener with the complimentary reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the device to the tissue.

Method of manufacturing an implantable film and prothesis comprising such a film

A method for manufacturing an implantable film and a prosthesis comprising such a film The present invention relates to a method for manufacturing a non porous film intended to be implanted in the human body, said method comprising the following steps: preparation of a first film, called intermediate film, via gelling of a starting solution comprising at least one polymer selected in the group consisting of collagen, glycosaminoglycans, and mixtures thereof, immersion of said intermediate film in an alkaline composition comprising at least one C 1 -C 4 alcohol, drying of the film obtained at the end of the immersing step. The invention also relates to a method for manufacturing a prosthesis comprising a textile support and such a film.

Assessment of Shear Forces Distribution at Fixation Points of Textile Based Implants

A system for assessing the distribution of shear forces at fixation points on a textile-based implant includes a tissue model, a load simulation device, and an analysis system. The tissue model includes an upper surface defining an opening therethrough and a fixation support configured to secure a textile-based implant against the upper surface at a plurality of fixation points defined along a plane of the upper surface. The load simulation device is configured to apply a load to a textile-based implant that is secured to the tissue model. A marker is disposed on the fixation support at one or more of the plurality of fixation points. The analysis system is configured to calculate a shear force vector at each of the fixation points where a marker is disposed in response to the load applied by the load simulation device.

Hernia prosthesis with marking means

Prosthesis (1) comprising a patch (2) made of biocompatible material, said patch having a generally plane geometric shape that defines two opposite faces, a centre, a length and a width of said patch, characterized in that said patch is provided, on one (2a) of its faces, with a single marking means (3) designed to indicate both the centre (C) of the patch and also the longitudinal direction of said patch.

Prosthesis for supporting a breast structure

The invention relates to a prosthesis for supporting a breast implant comprising: a reinforcement part configured to receive a curved lower portion of a breast implant, the reinforcement part having an elongation under 50N in the vertical direction of E1, a fixation part intended to be fixed to the pectoral muscle, the fixation part having an elongation under 50N in the vertical direction of E2, and a transition part connecting together the reinforcement part and the fixation part, said transition part having an elongation under 50N in the vertical direction of E3, wherein E3 is greater than E1 and greater than E2.

Synthetic prosthesis comprising a knit and a non porous film and method for forming same

The present invention relates to a synthetic prosthesis for tissue reinforcement comprising: a porous knit made from a monofilament of a synthetic biocompatible material, said knit defining two opposite faces, a first face and a second face, a synthetic non porous biodegradable film comprising at least a copolymer of at least ε-caprolactone, said film covering at least part of said first face, a synthetic biodegradable binder bonding said film to said first face, said binder comprising at least a polymer of ε-caprolactone, wherein said second face of said porous knit is left open to cell colonization. The invention also relates to a method for forming such a prosthesis.

Porous supports and vacuum hold down device using said supports

The present invention relates to a porous support (20) intended to be removably positioned on a top side (11b) of a perforated plate (11) of a table (10) of a vacuum hold down device (1), said perforated plate having a bottom side (11a) connected to a vacuum system (13) for producing reduced pressure on said bottom side, wherein the porous support comprises a perforated tray (21) provided on one side (21a) with outer reliefs (23) and on the other side (21b) with a blade penetrable porous structure (22) fixed thereon. The invention further relates to a vacuum hold down device (1) comprising such a support. The invention also relates to a process for replacing a first porous support by a second porous support in such a device.

Abdominal model for laparoscopic abdominal wall repair/reconstruction simulation

A physical abdominal surgical simulation system including an abdominal model mimicking the biomechanical properties and response of a patient specific abdomen and an image acquisition and analysis system. The abdominal model includes an abdominal wall model insert forming a frame of the abdominal model, an abdominal wall member secured to the abdominal wall model insert, a back member secured to the abdominal wall model insert in opposed relation with respect to the abdominal wall member, and an abdominal model cavity defined within abdominal wall model insert, the abdominal wall member, and the back member. The image acquisition and analysis system includes a plurality of cameras configured to capture images of the abdominal model cavity.

Textile-based prothesis for laparoscopic surgery

The invention relates to a prosthesis ( 1 ) comprising a textile ( 2 ) of elongate shape defining a longitudinal axis A, and a resilient frame ( 3 ) connected to said textile along substantially the peripheral edge of the textile, said frame forming, in the area of each short side of the textile, at least one U-shaped bend ( 4 ) extending in the direction of the longitudinal axis, said frame being able to adopt an unstressed configuration, in which said textile is deployed, and a stressed configuration, in which said frame is subjected to a radial force directed towards said longitudinal axis and said textile forms at least one longitudinal fold.

Package for a surgical mesh

The package ( 1 ) for a surgical mesh ( 100 ) comprises: a receiving member ( 2 ) configured and dimensioned to receive at least one surgical mesh ( 100 ), and a covering member ( 3 ) configured and dimensioned to cover the said at least one surgical mesh ( 100 ) maintaining with the receiving member ( 2 ) the surgical mesh ( 100 ) in a substantially flat position, and a gas channelling network interposed between the said receiving member ( 2 ) and the said covering member ( 3 ) configured to channel a sterilization gas within the at least one surgical mesh ( 100 ).

Gastric constriction device

Constriction device ( 1 ) which can be at least partially implanted in the human or animal body, comprising a constriction member ( 2 ) forming a ring in its operational configuration, said constriction member including a flexible band ( 12 ), of which the two ends ( 12 a, 12 b ) are adjacent to one another in the operational configuration, and a means ( 3 ) for actuating the constriction member, characterized in that, in cooperation, on the one hand, at least one end ( 12 b ) of the flexible band ( 12 ) includes a tractile element ( 13 ) for moving said end relative to the other end ( 12 a ), generating a radial deformation of the constriction member, and, on the other hand, the actuating means ( 3 ) comprises a member ( 25 ) for pulling the tractile element ( 13 ).

Bioresorbable knit

Bioresorbable three-dimensional prosthetic knits include a first porous face and a second porous face, the first face and the second face each containing yarns made of materials which undergo slow bioresorption and being opposite and separated from one another by the thickness of the knit and being connected to one another by a spacer. The spacer includes yarns made of materials which undergo slow bioresorption and yarns made of material which undergoes rapid bioresorption.

Bioresorbable knit

Medical device and method for making the same

Generation model and the system and method for simulating the influence to surgery surgical repair site

本发明提供了一种生成模型并模拟对外科手术修复部位的影响的系统和方法。提供了一种生成被固定至患者的可植入修复材料的基于计算机的可观察模型的方法。所述方法包括使用计算设备处理与患者相对应的数据，所述计算设备包括处理器和存储由处理器可执行的软件应用程序的存储器。所述方法还包括指示可植入修复材料和用于将可植入修复材料固定至患者的固定物以及指示所述固定物围绕可植入修复材料的分布。所述方法还包括在与计算设备可操作相关联的显示器上生成被固定至患者的可植入修复材料的可观察模型。所述可观察模型描绘了所指示的所述固定物围绕所述可植入修复材料的分布。

Method of forming a medical device on biological tissue

A method for in situ formation of a medical device on biological tissue includes attaching a plurality of reactive members of a primary specific binding pair to a surface of the biological tissue, and providing a plurality of fibers having attached thereto a plurality of complementary reactive members of the primary specific binding pair, wherein upon contact of the reactive members on the surface of the biological tissue with the complimentary reactive members on the fibers, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the fibers to the tissue. The fibers can incorporate functionalities which may cause them to bind to one another.

Medical devices incorporating functional adhesives

A method for bonding a polymeric medical device to tissue is provided which includes providing a polymeric medical device having a plurality of reactive members of a specific binding pair attached on a surface of the medical device, and providing tissue with a plurality of complementary reactive members of the specific binding pair, wherein upon contact of the reactive members on the surface of the medical device with the complimentary reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the device to the tissue. A kit is provided including a polymeric medical device such as a patch or mesh having a plurality of reactive members of a specific binding pair attached to a surface of the device and an applicator containing a solution or suspension of complementary reactive members of the specific binding pair, the complementary reactive members having a functionality that will adhere them to biological tissue upon contact, said applicator adapted to deliver the solution or suspension to biological tissue.

Crosslinked fibers and method of making same by extrusion

The present disclosure relates to a method of forming fibers. First and second precursors, each possessing a core and at least one functional group known to have click reactivity, are mixed. The mixed precursors are then extruded under heat to cross-link during fiber production.

Functionalized adhesive medical gel

A bioadherent substrate includes a medical gel or medical gel precursor having a plurality of reactive members of a specific binding pair attached on or adapted to be attached to a surface of the medical gel, said reactive members being capable of forming covalent bonds with a plurality of complementary reactive members of the specific binding pair via a reaction selected from a Huisgen cycloaddition reaction, a Diels-Alder reaction and a thiol-ene reaction. A method for adhering a medical gel to biological tissue includes providing a medical gel or a medical gel precursor having a plurality of reactive members of a specific binding pair attached on or adapted to be attached to a surface of the medical gel and providing tissue with a plurality of complementary reactive members of the specific binding pair, wherein upon contact of the reactive members on the medical gel with the complimentary reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the medical gel to the tissue.

Medical devices incorporating functional adhesives

Methods for treating a wound at a surgical target site are provided which includes utilizing a surgical access device having a plurality of reactive members of a specific binding pair releasably contained on a surface of the access device, the reactive members having affinity for binding a cellular component of tissue cells located at the target site; contacting the surface of the access device with the tissue cells, wherein upon contact of the reactive members on the surface of the access device with the tissue cells, the reactive members are released from the surface of the access device and bind to the tissue. A surgical access device for use in the minimally invasive surgery is also provided.

Medical device with predefined activated cellular integration

A medical device includes a substrate having at least a portion thereof functionalized with at least one reactive member and a chemotactic agent functionalized with at least one complementary reactive member. The at least one reactive member and the at least one complementary reactive member are covalently bonded, adhering the chemotactic agent to the substrate.

Medical device with inflammatory response-reducing coating

The present disclosure relates to implantable medical devices having a non-bioabsorbable substrate and an amphiphilic coating covalently bonded to the substrate for reducing the inflammatory response to the device after implantation.

Amphiphilic compounds and self-assembling compositions made therefrom

The present disclosure relates to amphiphilic compounds, self assembling compositions formed from the amphiphilic compounds and methods of making such compositions.

Functionalized surgical adhesives

A bioadherent composition includes a first mixture containing a plurality of reactive members of a specific binding pair, said reactive members being bound to a ligand capable of binding a receptor on biological tissue, and a second mixture containing a plurality of complementary reactive members of the specific binding pair, said complementary reactive members being bound to a ligand capable of binding a receptor on biological tissue, said reactive members capable of forming covalent bonds with said complementary reactive members via a reaction selected from Huisgen cycloaddition reactions, Diels-Alder reactions, and/or thiol-alkene reactions. A method for bonding biological tissue involves utilizing the bioadherent composition.

Compounds and medical devices activated with solvophobic linkers

The present disclosure relates to compounds and medical devices activated with a solvophobic material functionalized with a first reactive member and methods of making such compounds and devices.

Apparatus and method of reacting polymers passing through metal ion chelated resin matrix to produce injectable medical devices

The present disclosure relates to an apparatus and process for forming medical devices from an injectable composition. The apparatus includes a supply assembly configured to maintain and selective dispense a first precursor and a second precursor, a mixing assembly configured to mix the first and second precursors, and at least one catalyzing element including a transition metal ion to aid in the polymerization of the first and second precursors. The process includes dispensing a volume of the first precursor and a volume of the second precursor into a mixing assembly and mixing the first and second precursors. The first and second precursors each possess a core and at least one functional group known to have click reactivity with each other. The mixed precursors are contacted with a transition metal catalyst to produce a flowable composition for use as a medical device.

Surgical fasteners and methods for sealing wounds

A method for closing a wound in tissue is provided which includes providing a surgical fastener having a plurality of reactive members of a specific binding pair attached on a surface of the surgical fastener, and providing tissue with a plurality of complementary reactive members of the specific binding pair, wherein upon contact of the reactive members on the surface of the surgical fastener with the complimentary reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the device to the tissue.

Medical devices with an activated coating

Implantable medical devices include a substrate having applied thereto a coating including a polymeric material possessing a core and at least one functional group known to have click reactivity.

Apparatus and method of reacting polymers by exposure to UV radiation to produce injectable medical devices

Cross-linked compositions include a first precursor functionalized with a first reactive member and a second precursor functionalized with a second reactive member, the first and second reactive members covalently bonding with each other when exposed to UV radiation. The compositions are useful in a variety of surgical and wound treatment applications.

Crosslinked fibers and method of making same using UV radiation

Cross-linked fibers include first and second precursors, each possessing a core and at least one functional group known to have click reactivity when exposed to UV radiation. Mixtures of the first and second precursors are extruded to produce a filament and irradiated with UV light during the extrusion process.

Polymeric fibers having tissue reactive members

A method for bonding a polymeric fiber to tissue is provided which includes providing a polymeric fiber having a plurality of tissue reactive members linked to a surface of the fiber via a specific binding pair, and contacting the polymeric fiber to biological tissue, to covalently bond the fiber to the tissue.

Medical devices incorporating functional adhesives

A method for bonding a polymeric medical device to tissue is provided which includes providing a polymeric medical device having a plurality of reactive members of a specific binding pair attached on a surface of the medical device, and providing tissue with a plurality of complementary reactive members of the specific binding pair, wherein upon contact of the reactive members on the surface of the medical device with the complimentary reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the device to the tissue. A kit is provided including a polymeric medical device such as a patch or mesh having a plurality of reactive members of a specific binding pair attached to a surface of the device and an applicator containing a solution or suspension of complementary reactive members of the specific binding pair, the complementary reactive members having a functionality that will adhere them to biological tissue upon contact, said applicator adapted to deliver the solution or suspension to biological tissue.

A method for forming a barbed suture and the barbed suture thus obtained

Package for a surgical mesh

ADJUSTED ISOELASTIC PROSTHETIC FABRIC

THREE-DIMENSIONAL FILETWARE AS WALL REINFORCEMENT

DEVICE FOR TREATING PROLAPSUS BY VAGINAL SUSPENSION

SURGICAL BAND REEL

Pneumatic surgical instrument for the distribution and placement of connecting or fastening means

The handle body (A) constitutes one of the branches of a T, of which the other branch is formed by its attachment piece ( 2 ) which is continued by the interchangeable element (B), and this body includes, on the side toward the interchangeable element (B), indentations ( 26 ) for positioning the fingers of the hand, said indentations ( 26 ) being arranged on either side of the attachment piece, and of which one ( 26 a ), for positioning the index finger, is equipped with a bore through which there protrudes the push-button ( 14 ) for activating the pneumatic distributor ( 11 ).

Prosthesis for reinforcement of tissue structures

The present invention relates to a composite prosthesis for reinforcement of a tissue structure, including a porous textile support which includes an arrangement of threads each composed of at least one filament of nonabsorbable polymer material, said textile support defining a microporous texture including the interstices located between at least two threads at the sites of contact of one thread with at least one other thread, wherein, in at least one protected zone of the textile support, a hydrophilic absorbable material coats the textile support, forming a film enveloping and penetrating into the arrangement of threads, occluding at least the microporous texture, but without forming a plane layer covering at least one face of the textile support. It also relates to a process for preparing such a composite reinforcement prosthesis.

APPARATUS FOR STORAGE, DISTRIBUTION AND INSTALLATION OF SURGICAL ATTACHES

Reinforced composite implant

Multilayer structures including a porous layer and a non-porous layer having a reinforcement member are useful as implants.

Medical implant including a 3D mesh of oxidized cellulose and a collagen sponge

The present invention relates to A bioresorbable implant comprising: a bioresorbable porous layer including a biopolymer foam and defining first pores, a bioresorbable porous three-dimensional mesh made from a microbial cellulose and defining second pores, wherein the bioresorbable porous layer is disposed in the bioresorbable porous three-dimensional mesh. The invention also relates to a method of making a bioresorbable implant.

Knit with barbs on both faces

本发明涉及一种在其每个面上具有向外突出的倒钩的编织件，所述编织件通过如下方式得到：i）在至少四把梳栉上编织纱线，一把梳栉形成链，使两根针中的一根针空闲；两把梳栉穿有产生从所述编织件的面向外突出的线圈的单丝纱线；第四把梳栉建立其他三把梳栉的纱线之间的连接，ii）将在i）处得到的编织件热固化，iii）通过熔化线圈来形成倒钩。本发明还涉及一种包括这种编织件的修补件。

Medical device with inflammatory response-reducing coating

Implantable non-bioabsorbable medical devices have an amphiphilic coating for reducing the inflammatory response to the device after implantation.

Crosslinked fibers and method of making same using transition metal ions

Crosslinked fibers and method of making same using uv radiation

Crosslinked fibers and method of making same by extrusion

Surgical fasteners and methods for sealing wounds

The invention relates to a kit comprising a polymeric surgical fastener (110) having a plurality of reactive members of a specific binding pair attached to a surface of the surgical fastener and a container containing a liquid precursor including complementary reactive members of the specific binding pair. A method for closing a wound in tissue is provided which includes providing such a surgical fastener, and providing tissue with a plurality of complementary reactive members of the specific binding pair, wherein upon contact of the reactive members on the surface of the surgical fastener with the complimentary reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the device to the tissue.

Compounds and medical devices activated with solvophobic linkers

The present disclosure relates to compounds and medical devices activated with a solvophobic material functionalized with a first reactive member and methods of making such compounds and devices.

Compounds and medical devices activated with solvophobic linkers

The present disclosure relates to compounds and medical devices activated with a solvophobic material functionalized with a first reactive member and methods of making such compounds and devices.

Polymeric fibers having tissue reactive members

A method for bonding a polymeric fiber to tissue is provided which includes providing a polymeric fiber having a plurality of tissue reactive members linked to a surface of the fiber via a specific binding pair, and contacting the polymeric fiber to biological tissue, to covalently bond the fiber to the tissue.

Placement system for a means which reinforces a suture

Isoelastic porous mesh

lsoelastic porous meshes useful in hernia repair have pores that remain open under physiological loads.

METAL SUBSTRATE COATED WITH A COMPOSITION OF COLLAGEN AND POLYSACCHARIDES, PROCESS AND APPLICATIONS

GASTRIC RING OF TREATMENT OF OBESITY

Cellulose-containing medical device having a multi-layer structure produced without adhesive

Implants include a film layer containing cellulose secured to a surface of the porous layer that also contains cellulose, wherein the film layer is secured to the porous cellulose without the use of an adhesive.

SUB-URETRAL SUPPORT KIT FOR THE TREATMENT OF URINARY INCONTINENCE OF FEMALE EXERCISE

SUB-URETRAL SUPPORT KIT FOR THE TREATMENT OF URINARY INCONTINENCE OF FEMALE EXERCISE

The invention concerns a surgical assembly for supporting the urethra (1) in a woman, comprising a sub-urethral supporting tape (2) and a skin penetrating needle (3). The invention is characterised in that when combined: d) a composite strip (4) assembles at least both the sub-urethral supporting tape (2) and a flattened protective sheath (5) wherein said tape is arranged; e) the flattened sheath (5) comprises, lengthwise, two parts (51, 52) arranged on either side of a separation zone (6) wherein is provided cleavable linking means (7) between the two parts; f) the composite strip (4) comprises at each of its two ends (4a, 4b) a common part (81), for example a female part, of connecting means (8) capable of being locked and unlocked, while the proximal tip (31) of the skin penetrating needle (3) comprises another part (82), for example a male part, of said connection means (8).

SURGICAL CLIP FOR FIXING AND MAINTAINING A HERNIA PROSTHESIS

PROSTHESIS BASED ON TEXTILE FOR LAPAROSCOPIC PATHWAY

COMPLETE AND UNIVERSAL IMPLANT FOR THE REPAIR OF HERNIA BY ANTERIOR

GASTRIC RING OF TREATMENT OF OBESITY

APPARATUS FOR STORING, DISPENSING AND LAYING "I" LAYERED SURGICAL FASTENERS

Cet appareil comprend, dans un corps tubulaire (20), un coulisseau-magasin (22) solidaire d'une aiguille (50) et contenant lui-même des attaches (A), des moyens de distribution une à une des attaches et un poussoir d'éjection (42), apte à pousser dans l'aiguille la barre d'ancrage (2) de la première attache (A) en attente.Selon l'invention, le coulisseau-magasin (22) comporte :- au dessous de l'aiguille (50) un doigt transversal (59) apte, lors de la distribution de l'attache par déplacement de sa barre d'ancrage (2) au moyen du poussoir (42), à recevoir l'appui de l'extrémité aval (3a) de cette barre d'arrêt pour la forcer à basculer en soulevant son extrémité amont (3b),- à côté de l'aiguille (50), une nervure (51) saillant vers le bas et apte à guider le basculement de l'extrémité amont (3a) de la barre d'arrêt (3), pour que cette dernière ne vienne pas buter contre l'aiguille,- et, sur le doigt transversal (59), une face pentue (59a) chassant, transversalement et hors de ce doigt, l'extrémité aval (3a) de la barre d'arrêt (3).

THREE DIMENSIONAL PROTHETIC FABRIC WITH RESORBABLE DENSE FACE

La présente invention porte sur un tissu prothétique tridimensionnel comprenant une première et une deuxième faces, ladite première face et ladite deuxième face étant opposées et séparées l'une de l'autre par l'épaisseur dudit tissu, ladite première face étant poreuse, caractérisé en ce que ladite deuxième face est dense et réalisée en au moins un premier fil, résorbable. Elle porte également sur un procédé de préparation d'un tel tissu et sur une prothèse obtenue à partir d'un tel tissu. The present invention relates to a three-dimensional prosthetic fabric comprising a first and a second face, said first face and said second face being opposite and separated from each other by the thickness of said fabric, said first face being porous, characterized in that said second face is dense and made of at least one first absorbable thread. It also relates to a process for preparing such a tissue and to a prosthesis obtained from such a tissue.

Coating metal substrates with polysaccharide, e.g. for production of vascular endoprostheses, involves chemical modification, application of a reactive silane as coupling agent and coating with polysaccharide solution

Coating metal substrates with polysaccharides (I) involves: (1) pretreatment by chemical modification of the surface; and (2) application of an intermediate coating of a silane compound containing groups which react with the metal and groups which react with (I); before (3) application of a coating solution containing (I). Coating metal substrates with a layer of a polysaccharide compound (I), involves: (1) chemical modification of the metal surface, e.g. with a liquid modifier; (2) application of an intermediate coating of a silane compound (II), e.g. in solution, with two reactive groups, one for reaction with the metal and the other for direct or indirect reaction with (I); and (3) application of a coating material containing (I), e.g. in solution. Independent claims are also included for: (1) Metal substrates coated by this method; (2) Vascular endoprosthesis of the stent type comprising a coated metal substrate as in (1); and (3) Metal objects for medical or surgical applications, e.g. stents for transluminal percutaneous coronary angioplasty, comprising a coated metal substrate as above with a polysaccharide-based surface coating attached by covalent bonding to the substrate via an intermediate coating (II) with many grafting points consisting of silane units attached to the metal by metal-O- bonds and to the polysaccharide by covalent -NH- bonds.

Surgical fastener of sloping I-shape has anchoring bar made with tapered distal end with hemispherical tip to prevent core formation

The fastener (A), made in a sloping I-shape from anchoring (2), stop (3) and connecting (4) bars, has the distal portion (2a) of the anchoring bar made conical in shape, tapering towards a hemispherical tip (2c). The fastener is made from a biocompatible or bioresorbable plastic material, and once in place its overall length (L') is no more than 10.5 mm, and its overall height (H) no more than 6.1 mm. In addition, the distal portion has a tooth (2b) to protect the joint between the anchoring and connecting bars.

GASTRIC OBESITY TREATMENT RING

Cet anneau gastrique (1) comprend une bande (2) propre à entourer la paroi de l'estomac et des moyens (3, 7) permettant, après implantation, de modifier la section de l'ouverture délimitée par l'anneau (1).Selon l'invention,- la bande (2) comprend au moins une zone (2c) en un matériau déformable élastiquement dans le sens longitudinal de cette bande (2);- ladite zone (2c) présente au moins deux points d'appui (7) aménagés sur elle en deux emplacements séparés dans le sens longitudinal de la bande (2), et- l'anneau (1) comprend au moins un élément rigide (3) en un matériau biorésorbable, prenant appui contre ladite zone (2c} au niveau desdits points d'appui (7), cet élément rigide (3) permettant, avant résorption, de maintenir lesdits points d'appui (7) à une distance l'un de l'autre différente de la distance séparant ces deux points d'appui (7) en l'absence de déformation élastique de ladite zone (2c) de la bande (2), et, après résorption, ne faisant plus obstacle au retour de ladite zone (2c) de la bande (2) dans son état de non-déformation. This gastric ring (1) comprises a strip (2) suitable for surrounding the wall of the stomach and means (3, 7) allowing, after implantation, to modify the section of the opening delimited by the ring (1) .According to the invention, - the strip (2) comprises at least one zone (2c) made of an elastically deformable material in the longitudinal direction of this strip (2); - said zone (2c) has at least two support points (7) arranged on it in two separate locations in the longitudinal direction of the strip (2), and the ring (1) comprises at least one rigid element (3) made of a bioresorbable material, bearing against said zone (2c } at said support points (7), this rigid element (3) allowing, before absorption, to maintain said support points (7) at a distance from one another different from the distance separating these two support points (7) in the absence of elastic deformation ...

FABRIC WITH PICOTS COATED WITH WATER-SOLUBLE MATERIAL

La présente invention se rapporte à un tissu prothétique (5) comprenant un arrangement (2) de fils définissant au moins deux faces (2a, 2b) pour ledit tissu, ledit tissu comprenant sur au moins une de ses faces un ou plusieurs picots (3) saillant vers l'extérieur par rapport à ladite face, caractérisé en ce que lesdits picots sont recouverts d'un revêtement (6) en matériau biocompatible hydrosoluble. L'invention concerne également un procédé d'obtention d'un tel tissu et des prothèses obtenues à partir d'un tel tissu. The present invention relates to a prosthetic fabric (5) comprising an arrangement (2) of threads defining at least two faces (2a, 2b) for said fabric, said fabric comprising on at least one of its faces one or more pins (3). ) protruding outwardly with respect to said face, characterized in that said pins are covered with a coating (6) of water-soluble biocompatible material. The invention also relates to a process for obtaining such a fabric and prostheses obtained from such a fabric.

KNITTED PICOTS

La présente invention porte sur un tricot prothétique à base d'au moins un premier fil de matériau polymère biocompatible définissant une première et une deuxième faces opposées et ajourées, et d'au moins un deuxième fil, monofilament thermofusible et biocompatible, formant des picots saillant à l'extérieur d'au moins ladite première face et obtenus par fusion de boucles générées par ledit deuxième fil, le barème suivi pour le tricotage desdits premier(s) et deuxième fils sur un métier chaîne à trois barres à passettes B1, B2, B3 étant le suivant selon la norme ISO 11676 : - Barre B1 : 1.0/0.1// - Barre B2 : 1.0/7.7/6.6/7.7// - Barre B3 : 2.1/5.5/3.4/0.0// ledit deuxième fil suivant le barème de la barre B3. La présente invention porte également sur un procédé de fabrication d'un tel tricot. The present invention relates to a prosthetic knit based on at least a first yarn of biocompatible polymer material defining a first and a second opposite and perforated faces, and of at least a second yarn, hot melt and biocompatible monofilament, forming salient dots. outside of at least said first face and obtained by merging loops generated by said second yarn, the scale followed for the knitting of said first and second yarns on a three-bar bead chain loom B1, B2, B3 being the following according to the standard ISO 11676: - Bar B1: 1.0 / 0.1 // - Bar B2: 1.0 / 7.7 / 6.6 / 7.7 // - Bar B3: 2.1 / 5.5 / 3.4 / 0.0 // said second wire following the scale of the B3 bar. The present invention also relates to a method of manufacturing such a knit.

APPARATUS FOR STORING, DISPENSING AND LAYING SURGICAL I-LAYER FASTENERS

PROSTHESIS BASED ON TEXTILE FOR LAPAROSCOPIC PATHWAY

REINFORCING ELEMENT OF A TREILLIS

Device for ligating oblong anatomical structure e.g. ileo-caecal appendix during laparoscopy, has ligating component with two branches and setup using applicator which includes slider driving branches away or towards each other

L'invention concerne un dispositif pour ligaturer une structure anatomique qui comporte un élément de ligature ayant deux branches reliées par une charnière et des moyens (71, 73) pour lier entre elles les deux branches et un applicateur comportant un corps cylindrique ayant à son extrémité distale un logement pour recevoir l'élément de ligature, ce logement présentant une paroi latérale (40) contre laquelle est disposée la face externe de l'une des branches de l'élément de ligature, un coulisseau (80) monté mobile le long de la paroi latérale (40) et actionné par un organe de manoeuvre, des moyens (76) pour rapprocher ou écarter les deux branches de l'élément de ligature commandés par le coulisseau (80) et des moyens de mise en oeuvre (83, 85) des éléments de liaison (72, 73) des deux branches de l'élément de ligature par un élément de traction (86).

PROSTHETIC COMPRISING A REINFORCED TRELLIS

HEMOSTATIC PATCH AND PREPARATION METHOD

La présente invention porte sur un patch hémostatique comprenant une couche poreuse à base de cellulose oxydée et un film neutralisé à base de chitosane, ledit film comprenant une face libre et une face fixée à une des faces de la couche poreuse, et sur le procédé de préparation d'un tel patch comprenant les étapes suivantes : - a°) préparation d'une couche poreuse à base de cellulose oxydée, - b°) préparation d'un film à base de chitosane à partir d'une solution aqueuse acide de chitosane, - c°) fixation du film obtenu en b°) à une face de la couche poreuse, - d°) neutralisation du film obtenu en b°), - l'étape c°) pouvant être réalisée avant ou après l'étape d°), caractérisé en ce que : l'étape d°) de neutralisation comprend le traitement dudit film avec une composition neutralisante comprenant au moins de l'éthanol et de l'hydroxyde d'ammonium (NH4OH). The present invention relates to a hemostatic patch comprising a porous layer based on oxidized cellulose and a neutralized film based on chitosan, said film comprising a free face and a face attached to one of the faces of the porous layer, and on the method of preparation of such a patch comprising the following steps: - a) preparation of a porous layer based on oxidized cellulose, b) preparation of a film based on chitosan from an aqueous acid solution of chitosan - c) fixing the film obtained in b °) to one side of the porous layer, - d °) neutralization of the film obtained in b °) - step c °) can be performed before or after the step d °), characterized in that: the neutralization step d °) comprises treating said film with a neutralizing composition comprising at least ethanol and ammonium hydroxide (NH4OH).

SURGICAL STAPLER FOR PREPOSITIONING AND ATTACHING TEXTILE PROSTHESIS, METHOD OF LOADING THE SAME, AND SELF-AGRIPPTING SURGICAL STRAIN

La présente invention concerne une agrafe chirurgicale (100a) auto-agrippante comprenant une section médiane (101a) avec une surface distale (102a) et une surface proximale (103a), ladite agrafe chirurgicale (100a) comprenant en outre une partie distale allongée (104a) comprenant un pas de vis (105a) apte à pénétrer dans des tissus biologiques et s'étendant depuis ladite surface distale (102a), et des moyens de fixation amovible (106a) à un textile. Lesdits moyens de fixation amovible (106a) comprennent une pluralité de plots auto-agrippants (107a) formant harpon, lesdits plots auto-agrippants (107a) étant répartis sur la périphérie de ladite surface proximale (103a). La présente invention concerne également une agrafeuse chirurgicale (400) chargée avec au moins deux ensembles d'attaches (405, 406) chirurgicales de types différents délivrés dans un ordre préétabli. L'agrafeuse chirurgicale (400) selon l'invention est utilisable pour la mise en oeuvre d'une méthode chirurgicale de traitement des défauts herniaires. The present invention relates to a self-gripping surgical clip (100a) comprising a medial section (101a) with a distal surface (102a) and a proximal surface (103a), said surgical clip (100a) further comprising an elongated distal portion (104a). ) comprising a thread (105a) adapted to penetrate biological tissue and extending from said distal surface (102a), and detachable attachment means (106a) to a textile. The said removable attachment means (106a) comprise a plurality of self-gripping plummets (107a) forming a harpoon, the said self-gripping pads (107a) being distributed around the periphery of the said proximal surface (103a). The present invention also relates to a surgical stapler (400) loaded with at least two sets of surgical fasteners (405, 406) of different types delivered in a pre-established order. The surgical stapler (400) according to the invention can be used for the implementation of a surgical method for treating ...

PROSTHETIC WITH RADIO OPAQUE ELEMENT

DEVICE FOR PACKING AND FOLDING A PIECE OF SOFT MATERIAL, IN PARTICULAR A PARIETAL REINFORCEMENT

KNIT WITH PICOTS ON BOTH SIDES

La présente invention porte sur un tricot muni sur chacune de ses faces de picots saillant vers l'extérieur, obtenu par : -i) tricotage de fils sur au moins quatre barres à passettes, une barre formant chaînette laissant une aiguille libre sur deux ; deux barres enfilées en fil monofilament générant des bouclettes saillant à l'extérieur des faces dudit tricot; la quatrième barre réalisant la liaison entre les fils des trois autres barres, - ii) thermofixation du tricot obtenu en i), - iii) formation des picots par fusion des boucles. L'invention porte également sur une prothèse comprenant un tel tricot. The present invention relates to a knit provided on each of its outwardly protruding pin faces, obtained by: -i) knitting yarns on at least four guide bars, a bar forming a chain leaving one free needle out of two; two bars threaded monofilament wire generating loops protruding outside the faces of said knit; the fourth bar making the connection between the threads of the three other bars, ii) thermofixation of the knit obtained in i), iii) formation of the spikes by fusion of the loops. The invention also relates to a prosthesis comprising such a knit.

GASTRIC RING OF TREATMENT OF OBESITY

REINFORCING ELEMENT OF A TREILLIS

La présente invention porte sur un élément de renfort (200) pour un treillis circulaire, comprenant une pluralité de doigts (201) formant, au repos, une structure conique (202) pouvant s'ouvrir lorsque l'élément de renfort est placé sous contrainte axiale, chaque doigt comportant un segment sommital (201a) et un segment périphérique (201b) définissant une partie sommitale (202a) et une partie périphérique (202b) de ladite structure conique, ledit élément de renfort comprenant pour chaque doigt des moyens de désalignement (201c, 205 ; 402 ; 502) dudit segment sommital et dudit segment périphérique, au moins sous contrainte axiale dudit élément de renfort, lesdits moyens de désalignement autorisant dans ladite position sous contrainte axiale, d'une part la partie périphérique de ladite structure conique à adopter une configuration plane, et d'autre part ladite partie sommitale de ladite structure à conserver une forme conique. L'invention porte également sur une prothèse (300) comprenant un tel élément de renfort (200) associé à un treillis (1). The present invention relates to a reinforcing member (200) for a circular lattice, comprising a plurality of fingers (201) forming, at rest, a conical structure (202) that can be opened when the reinforcing member is under stress. axial, each finger having an upper segment (201a) and a peripheral segment (201b) defining a top portion (202a) and a peripheral portion (202b) of said conical structure, said reinforcing member comprising for each finger misalignment means ( 201c, 205; 402; 502) of said top segment and said peripheral segment, at least under axial stress of said reinforcing element, said misalignment means allowing in said axially stressed position, on the one hand the peripheral portion of said conical structure to adopt a planar configuration, and secondly said top portion of said structure to maintain a conical shape. The invention also relates to a prosthesis (300) comprising such a ...

PROSTHESIS FOR INGUINAL HERNIA

La présente invention porte sur une prothèse (1) pour la réparation d'une hernie inguinale, destinée à être implantée par voie laparoscopique postérieure ou ouverte, comprenant : un textile (2) ajouré en matériau biocompatible, comprenant une première face (2a), destinée à être placée en regard des tissus biologiques de la région inguinale, et une deuxième face (2b), opposée à ladite première face, destinée à être placée en regard du péritoine, ladite première face étant munie de moyens d'accroche aptes à fixer ledit textile dans lesdits tissus biologiques de la région inguinale, caractérisée en ce qu'au moins une partie de ladite deuxième face (2b) est recouverte d'un revêtement non poreux (7) constitué d'un matériau hydrosoluble à 37°C et non hydrosoluble à 25°C. L'invention porte encore sur un procédé de fabrication d'une telle prothèse. The present invention relates to a prosthesis (1) for the repair of an inguinal hernia, intended to be implanted posteriorly or openly laparoscopically, comprising: a textile (2) perforated biocompatible material, comprising a first face (2a), intended to be placed opposite the biological tissues of the inguinal region, and a second face (2b), opposite to said first face, intended to be placed facing the peritoneum, said first face being provided with attachment means able to fix said textile in said biological tissue of the inguinal region, characterized in that at least a portion of said second face (2b) is covered with a non-porous coating (7) consisting of a water-soluble material at 37 ° C and not water soluble at 25 ° C. The invention also relates to a method of manufacturing such a prosthesis.

PROSTHETIC FOR UMBILIC HERNIA

La présente invention porte sur une prothèse (200) comprenant : - un treillis (1) délimité par un bord extérieur périphérique (1a), - un cadre (2) solidaire dudit treillis et adoptant la forme dudit bord extérieur périphérique du treillis, situé en retrait dudit bord extérieur périphérique et étant pourvu de deux points dits points de charnière (3a, 3b), la ligne passant par lesdits deux points de charnière passant également par le centre (1 b) du treillis et formant ainsi une ligne de pliage M du treillis en deux parties, caractérisée en ce que ladite prothèse comprend en outre deux pièces d'ancrage (5) en matériau suturable situées sur une même face du treillis (1) de part et d'autre de ladite ligne de pliage, chaque pièce présentant une partie fixe (5a) liée audit treillis et une partie libre (5b), ladite partie libre étant reliée à au moins un élément filiforme (7). The present invention relates to a prosthesis (200) comprising: - a lattice (1) defined by a peripheral outer edge (1a), - a frame (2) integral with said lattice and adopting the shape of said outer peripheral edge of the lattice, located in removing said peripheral outer edge and being provided with two points called hinge points (3a, 3b), the line passing through said two hinge points also passing through the center (1b) of the lattice and thus forming a fold line M of trellis in two parts, characterized in that said prosthesis further comprises two anchoring pieces (5) of suturable material located on the same face of the trellis (1) on either side of said fold line, each piece having a fixed part (5a) connected to said lattice and a free part (5b), said free part being connected to at least one filiform element (7).

PROSTHESIS FOR INGUINAL HERNIA

The present invention relates to a prosthesis (1) for the repair of an inguinal hernia, which prosthesis (1) is intended to be implanted by a posterior or open laparoscopic route and comprises: an openworked textile (2) made of biocompatible material, comprising a first face (2a) intended to be placed facing the biological tissues of the inguinal region, and a second face (2b) arranged opposite said first face and intended to be placed facing the peritoneum, said first face being provided with fastening means that are able to fix said textile in said biological tissues of the inguinal region, characterized in that at least a part of said second face (2b) is covered with a non-porous coating (7) composed of a material that is hydrosoluble at 37°C and non-hydrosoluble at 25°C. The invention also relates to a method for producing such a prosthesis.

KNITTED PICOTS

The present invention relates to a prosthetic knit based on at least a first yarn of biocompatible polymer material defining first and second opposite and openwork faces, and on at least a second biocompatible and heat-fusible monofilament yarn, forming barbs that protrude outwards from at least said first face and are obtained by melting loops generated by said second yarn, the chart followed for the knitting of said first and second yarns on a warp knitting machine having three guide bars B1, B2, B3 being the following, according to the ISO 11676 standard: - Bar B1 : 1.0/0.1// - Bar B2: 1.0/7.7/6.6/7.7// - Bar B3: 2.1/5.5/3.4/0.0// said second yarn following the chart of bar B3. The present invention also relates to a process for manufacturing such a knit.

Loaded surgical stapler

The present invention relates to a surgical stapler loaded with at least two sets of surgical fasteners (405, 406) of different types that are delivered in a pre-established order. The invention also relates to a surgical kit comprising such a surgical stapler and a textile prosthesis.

EXTERNAL REINFORCEMENT OF VENOUS GRAFT

The invention concerns a venous graft external reinforcement comprising a porous tubular body having a diametrical dimension not greater than the maximum dimension of the vein section around which it is to be set, said body being formed by meshes whereof the yarns are made of polymeric material. It consists of an external tubular body (12), formed by a woven sheath, transversely and longitudinally inextensible; and an internal woven tubular sheath (13) extensible at least longitudinally, the meshes of said internal sheath (13) being formed by biocompatible monofilament plastic yarns and having a cross-section several times greater than that of the external sheath (12) meshes.

DEMAILABLE KNIT

PROSTHETIC FOR LAPAROSCOPIC PATH

La présente invention porte sur une prothèse (1) comprenant : - au moins un textile (2) biocompatible souple délimité par un bord extérieur périphérique (2a), - au moins un élément de renfort dudit textile, ledit élément de renfort étant sous la forme d'un cadre (3) solidaire dudit textile et adoptant substantiellement la forme dudit bord extérieur périphérique du textile, ledit cadre étant pourvu d'au moins quatre points de charnière (4a, 4b) permettant de plier ledit textile en deux parties selon un premier axe passant par le centre du textile, puis de nouveau en deux parties selon un deuxième axe passant par le centre du textile, ledit deuxième axe étant substantiellement perpendiculaire audit premier axe. The present invention relates to a prosthesis (1) comprising: - at least one flexible biocompatible textile (2) delimited by a peripheral outer edge (2a), - at least one reinforcing element of said textile, said reinforcing element being in the form a frame (3) secured to said textile and substantially adopting the shape of said peripheral outer edge of the textile, said frame being provided with at least four hinge points (4a, 4b) for folding said textile into two parts according to a first axis passing through the center of the textile, then again in two parts along a second axis passing through the center of the textile, said second axis being substantially perpendicular to said first axis.

Implant for replacing or reinforcing e.g. tendon, has collagen sponge based bioresorbable porous matrix and porous three dimensional knitted fabric defining pores partially interconnected between each other

The implant has a collagen sponge based bioresorbable porous matrix defining pores, where the collagen is a mixture of rapid in-vivo bioresorption collagen e.g. oxide collagen, and slowly in-vivo bioresorption collagen. Porous three dimensional knitted fabric defines other pores, where the two sets of pores are partially interconnected between each other. A part of the porous three dimensional knitted fabric is non-bioresorbable. The porous three dimensional knitted fabric has front and rear faces connected between each other by strut. The slowly in-vivo bioresorption collagen is collagen reticulated with reticulation agent e.g. glutaraldehyde, 2,3 glycidyl ether, carbodiimide, divinyl sulfone, hexamethylene diisocyanate or acyl azide.

SURGICAL STAPLER FOR PREPOSITIONING AND ATTACHING TEXTILE PROSTHESIS, METHOD OF LOADING THE SAME, AND SELF-AGRIPPTING SURGICAL STRAIN