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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 10204. Отображено 100.
06-12-2017 дата публикации

Устройство для изготовления косого шлифа

Номер: RU0000175485U1
Автор: Алина Юрьевна Фроликова, Константин Александрович Герасимов, Константин Львович Афанасьев
Принадлежит: Закрытое акционерное общество "ГРУППА КРЕМНИЙ ЭЛ"

Полезная модель относится к области электронной техники, а именно - к конструкции устройства для изготовления косого шлифа полупроводникового кристалла. Устройство состоит из пуансона, пресс-шайбы в виде цилиндра, на одном из оснований которого выполнена плоская фаска под углом косого шлифа, и наклеенного на плоскость фаски по линии пересечения плоскости фаски с основанием цилиндра исследуемого полупроводникового кристалла. При этом между исследуемым полупроводниковым кристаллом и фаской расположен сегмент плоскопараллельной пластины из того же материала что и исследуемый полупроводниковый кристалл, прямолинейный край которого совмещен с линией пересечения плоскости фаски и основания пресс-шайбы, а сам полупроводниковый кристалл смещен относительно прямолинейного края сегмента пластины на расстояние х, где х рассчитывается по формуле:,где К - коэффициент запаса для обеспечения начала шлифования сегмента плоскопараллельной пластины, а затем - шлифования исследуемого полупроводникового кристалла, равный 1,1-1,25; d - толщина исследуемого полупроводникового кристалла; α - угол между плоскостью фаски и основанием пресс-шайбы. Технический результат заключается в улучшении качества косых шлифов на небольших исследуемых кристаллах (размером менее чем 1,5×1,5 мм). 3 ил. Ц 1 175485 ко РОССИЙСКАЯ ФЕДЕРАЦИЯ 19 11 маза а за = (13 ВУ +4785 85091 (51) МПК ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ СОМ 13/00 (2006.01) (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (21)(22) Заявка: 2017120747, 13.06.2017 (24) Дата начала отсчета срока действия патента: 13.06.2017 Дата регистрации: 06.12.2017 Приоритет(ы): (22) Дата подачи заявки: 13.06.2017 (45) Опубликовано: 06.12.2017 Бюл. № 34 Адрес для переписки: 241037, г. Брянск, ул. Красноармейская, 103, ЗАО "ГРУППА КРЕМНИЙ ЭЛ", Технический отдел (72) Автор(ы): Афанасьев Константин Львович (КО), Герасимов Константин Александрович (КП), Фроликова Алина Юрьевна (КП) (73) Патентообладатель(и): Закрытое акционерное общество "ГРУИТА КРЕМНИЙ ЭЛ ...

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Номер записи: 1
07-12-2021 дата публикации

Учебно-демонстрационный комплекс

Номер: RU0000208190U1
Автор: Александр Павлович Белоглазов, Алексей Сергеевич Бородулин, Владимир Александрович Нелюб, Илья Владимирович Чуднов
Принадлежит: Общество с ограниченной ответственностью "Ниагара"

Полезная модель относится к области технологий производства изделий из композиционных материалов. Учебно-демонстрационный комплекс, представляющий собой устройство для проведения демонстрационных численных и физических экспериментов процесса вакуумной инфузии или вакуумного прессования изделий из полимерного композиционного материала, включающий в себя учебно-демонстрационный стенд для проведения процессов изготовления демонстрационных изделий из полимерного композиционного материала методами вакуумной инфузии или вакуумного прессования, с многоразовым вакуумным мешком, а также включающий сопутствующее программное обеспечение для численного моделирования технологических процессов. Стенд учебно-демонстрационного комплекса предназначен для проведения физических экспериментов с возможностью изменения отдельных технологических показателей и визуального наблюдения за возникающих при этом изменениях в ходе протекания технологических процессов. Стенд обеспечивает оптимизацию образовательного процесса за счет применения максимально адаптированного оборудования, закрепленного в единый мобильный блок и удобного для визуального наблюдения, применения единой системы электропитания, максимальной оптимизации времени проведения отдельных этапов техпроцесса и сокращения переходных этапов между ними. Техническим результатом заявленной полезной модели является оптимизация образовательного процесса. Технический результат достигается за счет использования специализированного комплекса, смонтированного в единый блок, удобный для транспортировки, быстрой пусконаладки и демонстрации всего процесса в одной зоне помещения, позволяющем проводить как числовые, так и физические эксперименты в обучающих целях. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 208 190 U1 (51) МПК G01N 11/00 (2006.01) G01N 33/44 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК G01N 11/00 (2021.08) (21)(22) Заявка: 2021128108, 24.09.2021 (24) Дата начала отсчета ...

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Номер записи: 2
19-01-2012 дата публикации

Method of determining subterranean formation parameters

Номер: US20120011927A1
Автор: Jean-Marc Donadille, Mohammed Badri, Patrice Ligneul
Принадлежит: Schlumberger Technology Corp

A method for assigning a wettability or related parameter to a subvolume of formation located between two or more boreholes is described with the method including the steps of obtaining measurements of the resistivity at the subvolume, obtaining further parameters determining a relation between resistivity and saturation from logging measurements along the two or more boreholes, obtaining geological measurement defining geological or rock-type boundaries within the formation between the two or more boreholes, selecting the subvolume such that it is not intersected by the geological or rock-type boundaries; transforming the resistivity measurements into the saturation at the subvolume; and—using the saturation and/or the further parameters to determine the wettability or related parameter for the subvolume.

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Номер записи: 3
22-03-2012 дата публикации

Systems and Methods for a Sample Fluid Collection Device

Номер: US20120067112A1
Автор: Adam Ernest Donath, Andreas Knaack, Benjamin Sullivan, Carl Gang Chen, Eric Donsky, Erol Craig Harvey, Fred Harry Davis, Graeme John Bullock, Matthew Daniel Solomon, Sasha Miu, Steve Zmina
Принадлежит: Tearlab Res Inc

A fluid collection device comprising a body comprising a capsule interface, and a capsule configured to interface with the body via the capsule interface and configured to hold a sample receiving chip. The sample receiving chip comprises a substrate that receives an aliquot volume of a sample fluid, wherein the substrate is operatively shaped to receive the aliquot volume of sample fluid through capillary action, and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region, whereupon energy properties of the sample fluid can be transduced to produce a sample fluid reading.

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Номер записи: 4
19-04-2012 дата публикации

Systems and methods for collecting tear film and measuring tear film osmolarity

Номер: US20120090388A1
Автор: Benjamin Sullivan, Eric Donsky
Принадлежит: Tearlab Res Inc

A sample receiving chip comprising a substrate that receives an aliquot volume of a sample fluid and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region. The energy imparted into the sample fluid is transduced by the sample region to produce an output signal that indicates energy properties of the sample fluid. The sample receiving chip also includes a channel formed in the substrate, the channel configured to collect the aliquot volume of a sample fluid and transfer the aliquot volume of sample fluid to the sample region.

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Номер записи: 5
21-06-2012 дата публикации

Wettability analysis of disaggregated material

Номер: US20120152547A1
Автор: Jerald J. Hinkel
Принадлежит: Schlumberger Technology Corp

A method for determining wettability of a solid, such as a reservoir rock material, is described. The method includes disaggregating the material, for example by grinding and placing the disaggregated material on the surface of the fluid. The wettability is analyzed based on whether a portion of the material floats on or sinks into the fluid. The method is well suited for heterogeneous solid materials that have mixed wetting characteristics and/or have varying surface types. The fluid can be evaluated as a potential treatment fluid or a component thereof that can be used for treating the rock formation. For example, the potential treatment fluid can include a surfactant or an oxidizing agent. A simple observation can be made whether substantially all of the material placed on the surface of the fluid sinks into the fluid, or the portions of floating and sinking material can be weighed.

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Номер записи: 6
01-11-2012 дата публикации

Method for determining turbidity point and free carbohydrate buffer coefficient of iron-carbohydrate complex

Номер: US20120276650A1
Автор: Chuanzheng Hua, Guoxin He, Jie Yang, Shoujun Xiong, Wen Fang
Принадлежит: Nanjing Lifenergy R&D Co Ltd

A method for determining a turbidity point and a free carbohydrate buffer coefficient of an iron-carbohydrate complex. The method includes: (1) contacting the complex with an acid; (2) determining hydrogen ion concentrations and solution turbidities of the complex in acid degradation; and (3) mathematically fitting the data, to obtain the turbidity point of the complex and the free carbohydrate buffer coefficient through mathematical treatment. A method for evaluating the safety of the iron-carbohydrate complex with the turbidity point and the free carbohydrate buffer coefficient.

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Номер записи: 7
28-03-2013 дата публикации

System and method for dissolution analysis of drug-eluting medical devices

Номер: US20130074587A1
Автор: Mel Merciadez
Принадлежит: Cordis Corp

This disclosure is directed to systems and methods for holding a medical device such as a stent undergoing dissolution analysis. A clip retains the device in a specific, reproducible orientation and positions it within a sample cell of the dissolution testing apparatus. Preferably, the medical device is positioned away from areas having relatively greater flow turbulence.

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Номер записи: 8
06-06-2013 дата публикации

METHODS TO CHARACTERIZE SAG IN FLUIDS

Номер: US20130139572A1
Автор: Jamison Dale E., Murphy Robert J.
Принадлежит:

Systems and methods for direct and indirect measurement of the density of a fluid which exhibits sag characteristics is disclosed. The sag measurement system includes a test container for holding a fluid mixture to be analyzed and a suction port on the test container. A pump is coupled to the suction port for circulating the fluid mixture from the test container through a circulation loop. A measurement device is coupled to the circulation loop and a return port directs the fluid mixture from the circulation loop back to the test container at substantially the same vertical location as the suction port. The fluid mixture flowing through the circulation loop passes through the measurement device before returning to the test container through the return port. The measurement device is operable to monitor the particle distribution of the fluid mixture as it changes due to gravity. 14-. (canceled)5. A method of analyzing sag performance comprising:placing a first fluid mixture to be analyzed in a test container;circulating the first fluid mixture through a first circulation loop including a density transducer;wherein the first fluid mixture enters and exits the first circulation loop through a first set of ports of the test container; andmonitoring a change in density of the first fluid mixture as a function of time.6. The method of claim 5 , further comprising:removing the first fluid mixture from the test container;cleaning the test container and the circulation loop;placing a second fluid mixture to be analyzed in the test container;circulating the second fluid mixture through the first circulation loop including the density transducer;wherein the second fluid mixture enters and exits the first circulation loop through the first set of ports of the test container;monitoring the change in density of the second fluid mixture as a function of time;comparing the change in density of the first fluid mixture over time with the change in density of the second fluid mixture ...

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Номер записи: 9
13-06-2013 дата публикации

DIHEDRAL SENSOR FOR EVALUATING TENSION, POTENTIAL AND ACTIVITY OF LIQUIDS

Номер: US20130145829A1
Автор: Gimenez Calbo Adonai
Принадлежит: EMBRAPA-EMPRESA BRASIILEIRA DE PESQUISA AGROPECUAR IA

In the dihedral sensor system, two flat plates are secured to a dihedron so that the distance (L) between the edge and the meniscus and the spacing between the plates (a) on the meniscus will be a function of the dihedron tangent (α). Thus, for pure water the tension (Ψ) is equal to the potential (T) and given by T=−2σ/[L tg(α)], wherein σ is the water surface tension. In order to measure water tension in the soil, the system is coupled to porous elements, while the sensor edge is pressed directly against roots and other plant organs. Water potential, instead, is measured with the edge positioned at a few micrometers from the sample and the response takes place after the exchange of a few picoliters of water, when the condition of balance of temperature and water vapor is approached. Visually, with a sliding gauge, one measures water tensions between zero and 0.3 MPa, while with the aid of a microscope the reading extends up to 3.0 MPa. The water activity corresponding to water potentials lower than −3.0 MPa can also be measured by adding a known number of molecules of solutes suitable for the water kept in the sensor. 12413. A sensor for evaluating tension , potential and activity of liquids , characterized by being constituted by two plates , an upper one () , by means of which the position (L) of the meniscus () is read , and a lower one () , secured on dihedron of angle α , the edge () of which has a junction between such plates , providing the constitution of a thin opening of contact with the sample.2. A sensor for evaluating tension claim 1 , potential and activity of liquids according to claim 1 , characterized by in that it is coupled claim 1 , markedly by means of its edge to a porous element for direct contact with the sample.3. A sensor for evaluating tension claim 2 , potential and activity of liquids according to claim 2 , characterized by having a porous element for direct contact with the sample claim 2 , which is elongate and provided with a side ...

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Номер записи: 10
13-06-2013 дата публикации

POTENCY TEST FOR VACCINE FORMULATIONS

Номер: US20130149726A1
Автор: ALLEN MICHELLE, BRUDERER URS PETER, GARRETT MARK, THIJSSEN MARTINUS ANTONIUS JOHANNES
Принадлежит:

The invention relates to certain methods for the determination of an antigen content of a first antigen in a mixture comprising two or more antigens. The invention also relates to a potency test for an antigen in a combination vaccine. The method allows the determination of the antigen content in a mixture additionally comprising antibodies that are capable of binding with the antigen. 2. (canceled)3. The method of claim 1 , wherein the immunoassay is an ELISA (enzyme linked immunosorbent assay).4. The method of claim 1 , wherein the mixture is a ready-to-use vaccine formulation.5. The method of claim 1 , wherein the mixture is incubated with an acid solution to dissociate the antigen-antibody complexes.6. The method of claim 5 , wherein the acid solution is a citric acid solution.7. The method of claim 5 , wherein the mixture is incubated with the acid solution for at least 8 hours.8. The method of claim 5 , wherein the mixture is incubated at a ratio (v/v) between the acid solution and the mixture of at least 25 claim 5 , preferably 25-75 claim 5 , more preferably 25-50.9. The method of claim 5 , wherein the acid solution has a pH of 1.0-3.0.10Mycoplasma hyopneumoniaeM. hyo. A method for the determination of an antigen content of a porcine circovirus type 2 (PCV-2) antigen in a mixture of at least a composition comprising the PCV-2 antigen and a composition comprising a () antigen claim 5 , the method comprising the steps of:a) mixing the two compositions; and{'i': 'M. hyo', 'b) determining the antigen content of the PCV-2 antigen by means of an immunoassay, characterized in that the antigen is obtained from a culture that does not comprise swine serum.'}11. A method for the determination of an antigen content of a first antigen in a mixture of at least a composition comprising the first antigen and a composition comprising a second antigen claim 5 , the method comprising the steps of:a) separating the second antigen from antibodies that are capable of binding ...

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Номер записи: 11
20-06-2013 дата публикации

METHODS FOR DETERMINING WETTABILITY ALTERATION

Номер: US20130152668A1
Автор: ABDALLAH WAEL, STUKAN MIKHAIL
Принадлежит: SCHLUMBERGER TECHNOLOGY CORPORATION

A protocol for determining the effect of water composition on surface alteration is described using simple and less preparation sensitive, brine/oil and rock/brine/air systems when compared to conventional rock/brine/oil measurement methods. A model glass/brine/oil system is described and it is demonstrated that experimental measurements of contact angle obtained using a conventional approach agree well with the contact angles predicted using the proposed protocol. 1. A method for determining wettability alteration due to fluid changes , the method comprising:measuring interfacial tension between a first liquid and a second fluid;measuring interfacial tension between the first liquid and a third fluid;measuring surface tension between the second fluid and a first reference fluid;measuring surface tension between the third fluid and the first reference fluid;measuring contact angle of the first liquid and a first solid surface in a second reference fluid;measuring contact angle of the second fluid and the first solid surface in the first reference fluid;measuring contact angle of the third fluid and the first solid surface in the first reference fluid; anddetermining a change in wettability for the first solid surface and the first liquid due to a change from the second fluid to the third fluid based at least in part on the measurements of interfacial tensions, surface tensions and contact angles.2. A method according to claim 1 , wherein said measurements are carried out using the same temperature and pressure.3. A method according to claim 1 , wherein the first reference fluid is air.4. A method according to claim 1 , wherein the second reference fluid is deionized water.5. A method according to claim 1 , wherein the second fluid is a liquid and the third fluid is a gas.6. A method according to claim 1 , wherein the second and third fluids are liquids.7. A method according to claim 1 , further comprising:measuring contact angle of the first liquid and a second ...

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Номер записи: 12
27-06-2013 дата публикации

Method of measuring the electroosmotic transport coefficient of a proton exchange membrane and device for implementing such a method

Номер: US20130166222A1
Автор: Arnaud Morin, Zhe Peng
Принадлежит: Commissariat a lEnergie Atomique et aux Energies Alternatives CEA

A method of determining the electroosmotic transport coefficient of a proton exchange membrane, the method including creating a stream of hydrated hydrogen on either side of the membrane which is permanently controlled so that the relative humidity is almost identical on each side of the membrane at any point, thereby making it possible to minimize any back diffusion into the membrane. Furthermore, the method includes estimating the back diffusion flux into the membrane from the rate of return to equilibrium of the relative humidity starting from the moment when the current is cut off.

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Номер записи: 13
01-08-2013 дата публикации

OIL MIGRATION SYSTEM

Номер: US20130192347A1
Автор: Dwyer Richard, Reedy John, Rogers Steve
Принадлежит: K&N Engineering, Inc.

An apparatus and a system is provided that may be utilized to determine oil migration and oil displacement from a pre-oiled air filter. The present invention may also be utilized to determine if oil is displaced from the air filter onto a portion of the apparatus for visualization to a user. The present invention utilizes a demonstration apparatus having a system for forcing air through the oil subjected air filter thereby attempting to force displacement of the oil from the air filter. The apparatus utilizes a blowing means whereby the oil infused air filter is subject to higher than normal air flow and whereby the apparatus has a deflection portion whereby if oil is displaced from the air filter, it is deflected onto the deflection portion where it would be physically viewable to an observer present in the vicinity of the apparatus. 1. An apparatus for determining oil displacement from a filtration media , the apparatus comprising:a container means having at least a side, and a top and bottom portion;an accommodation portion whereby the accommodation portion has an opening thereon for accommodating an air filtration media;a blower means for directing air flow through the air filtration media; andan extension receptacle positioned above the air filtration media.2. The apparatus of wherein the accommodation portion holds an air filtration media.3. (canceled)4. (canceled)5. The apparatus of wherein the extension receptacle positioned above the air filtration media has a top portion claim 1 , a bottom portion and two side portions whereby a wedge it formed between the two side portions wherein said wedge extends downwards from the bottom portion of the extension receptacle.6. (canceled)7. (canceled)8. (canceled)9. (canceled)10. (canceled)11. (canceled)12. (canceled)13. A system for determining displacement from a filtration media claim 1 , the system comprising:a container means having an accommodation portion whereby the accommodation portion has an opening thereon ...

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Номер записи: 14
01-08-2013 дата публикации

Ingestible Circuitry

Номер: US20130193950A1
Автор: COSTELLO BENEDICT, Hafezi Hooman, SNYDER ERIC J.
Принадлежит: PROTEUS DIGITAL HEALTH, INC.

The present invention provides for safe and reliable electronic circuitry that can be employed in ingestible compositions. The ingestible circuitry of the invention includes a solid support; a conductive element; and an electronic component. Each of the support, conductive element and electronic component are fabricated from an ingestible material. The ingestible circuitry finds use in a variety of different applications, including as components of ingestible identifiers, such as may be found in ingestible event markers, e.g., pharma-informatics enabled pharmaceutical compositions. 1. An device comprising:a support;a first electrode connected to the support;a second electrode connected to the support; anda control circuit for controlling current flow, wherein the control circuit is secured to the support and wherein the first electrode is electrically coupled to the control circuit at a first input and the second electrode is electrically coupled to the control circuit at a second input,wherein the first and second electrodes are made of dissimilar materials that are capable of providing a voltage potential when in contact with a conducting fluid.2. The device of claim 1 , wherein the control circuit is activated when the device contacts the conducting fluid claim 1 , which causes a voltage potential between the first and second electrodes that powers the control circuit.3. The device of wherein the control circuit produces a unique current signature by controlling the current path created between the first and second electrode through the conducting fluid.4. The device of wherein the support and control circuit are ingestible and at least one of the first and second electrodes is digestible.5. The device of claim 1 , wherein the first and second electrodes are created through deposition of a digestible material onto the support.6. The device of claim 1 , further comprising:a backing layer;a release layer laminated on one side thereof to the backing layer;a metallic ...

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Номер записи: 15
01-08-2013 дата публикации

SYSTEMS AND METHODS FOR COLLECTING TEAR FILM AND MEASURING TEAR FILM OSMOLARITY

Номер: US20130196344A1
Автор: DONSKY Eric, Sullivan Benjamin
Принадлежит: Tearlab Research, Inc.

A sample receiving chip comprising a substrate that receives an aliquot volume of a sample fluid and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region. The energy imparted into the sample fluid is transduced by the sample region to produce an output signal that indicates energy properties of the sample fluid. The sample receiving chip also includes a channel formed in the substrate, the channel configured to collect the aliquot volume of a sample fluid and transfer the aliquot volume of sample fluid to the sample region. 144.-. (canceled)45. A method for detecting or measuring an analyte of interest in tear fluid , comprising:i. contacting a substrate with an aliquot volume of tear fluid;ii. transferring energy to the aliquot volume of tear fluid; andiii. detecting energy transfer properties of the aliquot volume of tear fluid to produce a tear fluid reading, wherein the tear fluid reading is correlated to presence or quantity of an analyte of interest in the aliquot volume of tear fluid.46. The method of claim 45 , wherein the energy is optical energy.47. The method of claim 46 , comprising detecting the energy transfer properties of the aliquot volume of tear fluid by surface plasmon resonant transduction.48. The method of claim 45 , further comprising contacting the substrate with an eye of an individual and receiving the aliquot volume of tear fluid.49. The method of claim 45 , wherein the analyte of interest is a biomarker.50. The method of claim 45 , wherein the analyte of interest is osmolarity.51. The method of claim 45 , wherein the analyte of interest is a protein claim 45 , peptide claim 45 , or oligonucleotide.52. The method of claim 45 , wherein the analyte of interest is an immunoglobulin claim 45 , cytokine or mucin.53. The method of claim 52 , wherein the analyte of interest is lactoferrin claim 52 , TGFbeta claim 52 , TNFalpha claim 52 , Interleukin 1-A ...

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Номер записи: 16
01-08-2013 дата публикации

BACTERICIDAL ANTIBODY ASSAYS TO ASSESS IMMUNOGENICITY AND POTENCY OF MENINGOCOCCAL CAPSULAR SACCHARIDE VACCINES

Номер: US20130196352A1
Автор: Balocchi Cristiana, Donnelly John, GIULIANI Marzia Monica, Luzzi Enrico, MORI Elena, Paludi Marilena
Принадлежит: NOVARTIS AG

The disclosure provides compositions, methods and kits for assessing immunogenicity, potency, or both, of meningococcal capsular saccharide vaccines. The assessment is based upon measurement of binding of a bactericidal antibody to a capsular saccharide component in the vaccine. 1. A method of assessing immunogenicity of a meningococcal capsular saccharide vaccine for regulatory release comprising:(a) contacting the meningococcal capsular saccharide vaccine with a bactericidal antibody and optionally a control saccharide;(b) assessing the immunogenicity of the meningococcal capsular saccharide vaccine by measuring the binding of the bactericidal antibody to the meningococcal capsular saccharide vaccine or optionally to the control saccharide; and(c) releasing the meningococcal capsular saccharide vaccine if the immunogenicity meets regulatory requirements for release,{'i': N. meningitidis', 'N. meningitidis', 'N. meningitidis', 'N. meningitidis, 'wherein the meningococcal capsular saccharide vaccine comprises at least two saccharides selected from (i) an serogroup A capsular saccharide, (ii) an serogroup C capsular saccharide, (iii) an serogroup W135 capsular saccharide, and (iv) an serogroup Y capsular saccharide, and wherein the bactericidal antibody binds to one of the at least two saccharides and, optionally, to the control saccharide.'}2. The method of claim 1 , wherein the regulatory release requirements comprise a minimum immunogenicity requirement and a measurement reliability requirement.3. The method of claim 2 , wherein the measurement reliability requirement is a coefficient of variation of the measurements being less than a maximum value.4. The method of claim 3 , wherein the maximum value is a coefficient of variation of repeatability (all antigens) of 15%.5. The method of claim 1 , wherein the regulatory requirements are as determined by the U.S. Food and Drug Administration or the European Medicines Agency.6. The method of claim 1 , wherein the at ...

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Номер записи: 17
08-08-2013 дата публикации

METHOD FOR EVALUATING THE SOLUBILITY OF A CRYSTALLINE SUBSTANCE IN A POLYMER

Номер: US20130199313A1
Автор: Maegerlein Markus, SUN Ye, Tao Jing, YU Lian, ZHANG Geoff G.
Принадлежит:

A method for evaluating the solubility of a crystalline substance in a polymer comprises a) providing at least one sample of an intimate crystalline substance/polymer mixture at a predetermined crystalline substance concentration; b) annealing the sample at a constant temperature Tfor a period of time; c) heating the annealed sample while recording the heat flux over time by DSC; d) identifying a DSC dissolution endotherm in the recorded heat flux, if any; e) considering the crystalline substance concentration as a concentration above the crystalline substance solubility in the polymer at temperature Twhen there is a DSC dissolution endotherm identified, and considering the crystalline substance concentration as a concentration less than or equal to the crystalline substance solubility in the polymer at temperature Twhen there is no DSC dissolution endotherm identified. Thus, the method yields the upper and lower bounds for the equilibrium solubility at a given temperature or the upper and lower bounds for the equilibrium solubility temperature at a given crystalline substance concentration. The method improves accuracy of measurement near the glass transition temperature. 1. A method for evaluating the solubility of a crystalline substance in a polymer , comprisinga) providing at least one sample of an intimate crystalline substance/polymer mixture at a predetermined crystalline substance concentration;{'sub': 'a', 'b) annealing the sample at a constant temperature Tfor a period of time;'}c) heating the annealed sample while recording the heat flux over time by DSC;d) identifying a DSC dissolution endotherm in the recorded heat flux, if any;{'sub': a', 'a, 'e) considering the crystalline substance concentration as a concentration above the crystalline substance solubility in the polymer at temperature Twhen there is a DSC dissolution endotherm identified, and considering the crystalline substance concentration as a concentration less than or equal to the ...

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Номер записи: 18
29-08-2013 дата публикации

LIQUID CRYSTAL DEVICE FOR SCREENING CLEANERS OF BIOFOULING OR FOR VALIDATING CLEANING PROCESSES

Номер: US20130224780A1
Автор: Abbott Nicholas L., Tan Lie Na
Принадлежит: WISCONSIN ALUMNI RESEARCH FOUNDATION

Methods and devices for assaying the effectiveness of a cleaning composition in removing a protein or a biofilm from a surface are disclosed. Such methods include the steps of providing one or more proteins at an interface between an aqueous phase and a liquid crystal phase or at the surface of a liquid crystal, contacting the interface or liquid crystal surface with a cleaning composition, and observing the orientational ordering of the liquid crystal at the interface or liquid crystal surface. A continuous change in the orientational ordering of the liquid crystal at the interface or liquid crystal surface indicates that the proteins are being removed from the interface, and the rate of change in orientational ordering, the extent of the change in orientational ordering, or both, are correlated with the effectiveness of the cleaning composition. Because the ability of cleaning agents to remove proteins from the interface or liquid crystal surface is correlated with the state and concentration of the protein that is being removed, similar methods and devices can be used to assay the effectiveness of a putative protein stabilizing agent or to assay the optimal concentration of a protein for preventing the unfolding of the protein. 1. A method for assaying the effectiveness of a cleaning composition in removing a protein or a biofilm from a surface , the method comprising:(a) providing one or more proteins at an interface between an aqueous phase and a liquid crystal phase;(b) contacting the interface with a cleaning composition; and(c) observing the orientational ordering of the liquid crystal at the interface;wherein a continuous change in the orientational ordering of the liquid crystal at the interface indicates that the proteins are being removed from the interface, and wherein the rate of said change in orientational ordering, the extent of said change in orientational ordering, or both, are correlated with the effectiveness of the cleaning composition in ...

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Номер записи: 19
12-09-2013 дата публикации

Biomarker normalization

Номер: US20130233061A1
Автор: Benjamin Sullivan
Принадлежит: UNIVERSITY OF CALIFORNIA

A fluid sample is measured with a tear film measuring system that includes is processing device that receives a sample chip comprising a sample region configured to contain an aliquot volume of sample fluid, the processing device configured to perform analyses of osmolarity and of one or more biomarkers within the sample fluid, wherein the analysis of biomarkers includes normalization of biomarker concentration values.

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Номер записи: 20
19-09-2013 дата публикации

METHOD OF REGULATING THE VISCOSITY OF A MIXTURE COMPRISING AT LEAST TWO COMPONENTS HAVING DIFFERENT VISCOSITIES

Номер: US20130240779A1
Автор: THIELE Kai
Принадлежит: BASF SE

The invention relates to a method of regulating the viscosity of a mixture () comprising at least two components having different viscosities, which comprises the steps: 1125210. A method of regulating the viscosity of a mixture (; ) comprising at least two components having different viscosities , which comprises the steps:{'b': 125', '210, '(a) determination of the viscosity of the mixture (; ) by means of ultrasound measurements,'}{'b': 132', '222, '(b) standardization of the viscosity determined (; ) to standard conditions,'}{'b': 134', '224, '(c) comparison of the standardized viscosity with a prescribed intended value (; ),'}{'b': 125', '210, '(d) adjustment of the viscosity of the mixture (; ) by increasing or decreasing the proportion of at least one component of the mixture,'}where the ultrasound measurements in step (a) are carried out at or in a line conveying the mixture or in a vessel.2125112. The method according to claim 1 , wherein the mixture () composed of a plurality of components is obtained from a crude mixture () by distillation or crystallization claim 1 , with at least one component being at least partly separated off.3125130. The method according to claim 2 , wherein the viscosity of the mixture () obtained by distillation or crystallization is determined by means of ultrasound measurements () in the outflow stream.4. The method according to claim 2 , wherein the adjustment of the viscosity in step (d) of the method is effected by increasing or decreasing the amount separated off of at least one component separated off by distillation or crystallization by changing the introduction of energy or removal of energy.5. The method according to claim 2 , wherein the adjustment of the viscosity in step (d) of the method is effected by mixing in a partial amount of at least one component separated off by distillation or crystallization or by mixing in a crude product mixture having a different composition.6. The method according to claim 2 , wherein ...

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Номер записи: 21
26-09-2013 дата публикации

VACCINES

Номер: US20130251738A1
Автор: Coldham Nicholas G., Humphryes Phillip C.
Принадлежит: The Secretary of State for Environment, Food & Rural Affairs

There is provided a method of identifying a protective vaccine composition, comprising determining that the composition contains a protective concentration of a Lipl32 epitope polypeptide, for example, of a polypeptide comprising SEQ ID NO:13 or an antigenic variant or portion thereof. There is also provided a vaccine composition comprising a protective concentration of at least one Lipl32 epitope polypeptide having up to 250 amino acids and comprising SEQ ID NO:13 or an antigenic variant or portion thereof. There is further provided a method of identifying an immunogenic element in a vaccine composition comprising submitting the composition to a two-dimensional liquid chromatography mass spectrometry (2D LC/MS) process. 1Leptospira. A method of identifying a protective vaccine composition , comprising determining that the composition contains a protective concentration of a Lipl32 epitope polypeptide.2. The method of in which a Normalised Spectrum Abundance Factor is measured for the Lipl32 epitope polypeptide and found to be higher in the protective vaccine composition than in a known non-protective vaccine composition.3. The method of comprising determining that the composition contains a protective concentration of a polypeptide comprising SEQ ID NO:13 or an antigenic variant or portion thereof.4LeptospiraLeptospira. The method of wherein the vaccine composition comprises an attenuated species.5LeptospiraL. interrogans, L. kirschneri, L. noguchii, L. alexanderi, L. weilii, L.L. borgpetersenii, L. santarosai, L. kmetyi, L. canicolaL. icterohaemorragiae.. The method of wherein the attenuated species is genomospecies 1 claim 4 , or6. The method of wherein the Lipl32 epitope polypeptide is SEQ ID NO:13.7. The method of wherein the protective concentration of Lipl32 epitope polypeptide is at least 0.25_fmol/μg vaccine protein.8. The method of wherein the protective concentration of Lipl32 epitope polypeptide is at least 0.5_fmol/μg vaccine protein.9. The method of ...

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Номер записи: 22
31-10-2013 дата публикации

METHOD FOR CULLET QUALITY GRADING

Номер: US20130283937A1
Автор: Sabet Shahriar
Принадлежит:

A method for grading the quality of cullet. Some embodiments include methods for generating a statistically significant sample of material from a collection of cullet contaminated with waste. Other embodiments include methods for evaluating various qualities of the sample with relatively simple techniques. Yet other embodiments include a uniform and reasonably simple method for communicating the results of the evaluation among different parties. 1. A method for evaluating cullet , comprising:providing a quantity of cullet contaminated with other waste products;removing a sample from the quantity;counting the number of non-glass objects in the sample larger than a predetermined size;associating a first numerical grade with the number;separating from the sample cullet of one of the colors of amber, green, or flint and determining the weight fraction of that color within the sample;associating a second numerical grade with the weight fraction; andevaluating the usefulness of the quantity in a glass furnace using the first numerical grade and the second numerical grade.2. The method of which further comprises drying the sample and determining the fraction of weight lost by drying and associating a third numerical grade with the dried weight fraction claim 1 , wherein said evaluating uses the third numerical grade.3. The method of which further comprises rinsing the sample and determining the fraction of weight lost by rising and associating a third numerical grade with the rinsed weight fraction claim 1 , wherein said evaluating uses the third numerical grade.4. The method of which further comprises rinsing the sample and determining the fraction of weight lost by rising and associating the rinsed weight fraction with the weight loss by ignition claim 1 , wherein said evaluating uses the weight loss by ignition.5. The method of which further comprises determining the weight percentage of cullet particles smaller than a predetermined size in the sample and associating a ...

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Номер записи: 23
14-11-2013 дата публикации

CAVITATION SENSOR

Номер: US20130298646A1
Автор: Gonzalez-Avila Silvestre Roberto, Ohl Claus-Dieter
Принадлежит:

According to various embodiments, a cavitation sensor for detecting bubbles in a liquid is provided. The cavitation sensor may include: a substrate having an insulative surface; and an electrode arrangement provided on or within the insulative surface of the substrate. The electrode arrangement may include a first electrode and a second electrode being isolated from each other by the insulative surface, each of the first and the second electrode including a sensing portion. The spacing between the sensing portion of the first electrode and the sensing portion of the second electrode is adapted to allow charge flow between the first electrode and the second electrode caused by cavitation occurring at the sensing portion. 1. A cavitation sensor for detecting bubbles in a liquid , the cavitation sensor comprising:a substrate having an insulative surface; andan electrode arrangement provided on or within the insulative surface of the substrate; wherein the electrode arrangement comprises a first electrode and a second electrode being isolated from each other by the insulative surface, each of the first and the second electrode comprising a sensing portion, wherein the spacing between the sensing portion of the first electrode and the sensing portion of the second electrode is adapted to allow charge flow between the first electrode and the second electrode caused by cavitation occurring at the sensing portion;wherein the sensing portion of the first electrode and the sensing portion of the second electrode are configured to remain stationary relative to the substrate, to detect a change in the velocity of liquid flowing parallel to the substrate surface where the electrode arrangement is provided on.2. (canceled)3. The cavitation sensor of claim 1 , wherein the electrode arrangement is a layer having a thickness of around 300 nm.4. The cavitation sensor of claim 1 , wherein the sensing portion of the first electrode and the sensing portion of the second electrode each ...

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Номер записи: 24
14-11-2013 дата публикации

MEASUREMENT OF INTERFACIAL PROPERTY

Номер: US20130298649A1
Автор: Clarke Andrew
Принадлежит: SCHLUMBERGER TECHNOLOGY CORPORATION

Interfacial tension between first and second immiscible liquids is determined using a device in which entrance and exit channels are connected by a cavity with wider cross-section. A flow of the first liquid enters the cavity as a jet and breaks into droplets within the cavity. Passage of a droplet through the exit channel feeds back to perturb the jet entering the cavity. An alternating signal applied to a heating element perturbs the incoming jet and is progressively scanned over a frequency range which includes the system's resonant frequency (frequency of droplet formation with no signal to the heating element). A bandwidth of frequency is observed in which the frequency of droplet formation is phase locked to the frequency applied to the heater. The ratio of resonant frequency to this bandwidth is a measurement of the interfacial tension between the two liquids. 1. A method of determining interfacial tension between first and second immiscible liquids , comprising:directing a flow of the first liquid surrounded by a flow of the second liquid into a succession of three channels comprising an entrance channel, a cavity and exit channel , wherein the cavity connects the entrance and exit channels and has a wider cross-section for flow than both the entrance and exit channels,wherein the first liquid enters the cavity as a jet and breaks into droplets within the cavity, andwherein passage of a droplet through the exit channel creates a perturbation which feeds back to perturb the jet entering the cavity;supplying an alternating signal to perturb the incoming jet of the first liquid at the frequency of the supplied alternating signal; andvarying the frequency of the supplied alternating signal over a range while observing the frequency of droplet formation to determine a frequency bandwidth within which formation of droplets takes place at the frequency of the supplied alternating signal.2. A method according to claim 1 , further comprising directing the flows of ...

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Номер записи: 25
28-11-2013 дата публикации

SYSTEMS AND METHODS FOR DETECTION OF PARTICLES IN A BENEFICIAL AGENT

Номер: US20130316934A1
Автор: MATAYOSHI EDMUND, WANG JIE
Принадлежит:

Detection of particles in a liquid beneficial agent contained within a container includes selectively illuminating at least a portion of the liquid beneficial, obtaining an image from the illuminated portion of the liquid beneficial agent, analyzing image data representing the image, using a data processor, to obtain a particle concentration, measuring an image intensity value of the image data using the data processor, and determining a quality level of the liquid beneficial agent using the data processor based on the particle concentration and the measured image intensity value. 1. A method for detection of particles in a liquid beneficial agent contained within a container , comprising:selectively illuminating at least a portion of the liquid beneficial agent;obtaining an image from the illuminated portion of the liquid beneficial agent;analyzing image data representing the image, using a data processor, to obtain a particle concentration;measuring an image intensity value of the image data using the data processor; anddetermining a quality level of the liquid beneficial agent using the data processor based on the particle concentration and the measured image intensity value.2. The method according to claim 1 , wherein selectively illuminating the portion of the liquid beneficial agent comprises focusing light through an optical element corresponding to the container to provide an undistorted image of the liquid beneficial agent.3. The method according to claim 1 , wherein selectively illuminating the portion of the liquid beneficial agent comprises forming a thin sheet of illumination in the illuminated portion of the liquid beneficial agent.4. The method according to claim 1 , wherein the liquid beneficial agent is selectively illuminated with light having a wavelength in a range from about 200 nm to about 1100 nm.5. The method according to claim 1 , wherein the image is obtained by light scattering from particles in the illuminated portion of the liquid ...

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Номер записи: 26
06-02-2014 дата публикации

Methods and apparatus to determine diffusion properties of porous structures for drug delivery

Номер: US20140033800A1
Автор: Cary Reich, Kathleen Cogan Farinas, Michael S. Barrett, Randolph E. Campbell, Signe Erikson
Принадлежит: ForSight Vision4 Inc

Disclosed herein are improved therapeutic devices and methods and improved porous structures and measurement apparatus for use with therapeutic devices. In many embodiments, a porous structure is measured based on diffusion of the gas through the porous structure. The gas measurement may comprise an amount of gas measured to determine a resistance of the porous structure to diffusion. The diffusion of the gas through the porous structure can be used to determine release of a therapeutic agent through the porous structure, such that targeted amounts of therapeutic agent can be released for extended times and such that therapeutic device reservoir volume and porous frit structure can be tuned to release the therapeutic agent for an extended time above a target amount for the extended time.

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Номер записи: 27
13-02-2014 дата публикации

System and Method for Drug Detection Using SWIR

Номер: US20140043488A1
Автор: Gardner Charles, Nelson Matthew, Treado Patrick
Принадлежит: ChemImage Corporation

A method for detecting unknown materials, such as drugs. A first location is surveyed using a video capture device to identify a second location comprising an unknown material. The second location is interrogated using SWIR spectroscopic and/or imaging methods to generate a SWIR hyperspectral image. The SWIR hyperspectral image is analyzed to associate the unknown material with a known drug material. A system for detecting unknown materials, such as drugs comprising a first collection lens for collecting interacted photons from a first location and a visible imaging device for generating a visible image. A second collection lens may collect a plurality of interacted photons from a second location and a tunable filter may filter the interacted photons. A spectroscopic imaging device may detect the interacted photons and generate a SWIR hyperspectral image. A processor may analyze the SWIR hypespectral image to associate an unknown material with a known material. 1. A system for detecting drug materials comprising:a first collection lens configured to collect a first plurality of interacted photons from a first location comprising an unknown material;a visible imaging device configured for detecting the plurality of interacted photons and generating a visible image of the first location;a second collection lens for focusing and locating a second location comprising at least one unknown material and collecting a second plurality of interacted photons from the second location;a tunable filter for filtering the second plurality of interacted photons into a plurality of wavelength bands;a spectroscopic imaging device configured to detect the second plurality of interacted photons and generate a SWIR hyperspectral image of the second location; andat least one processor configured to analyze the SWIR hyperspectral image to associated the unknown material with at least one known material, wherein the known material comprises at least one drug.2. The system of wherein the ...

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Номер записи: 28
13-02-2014 дата публикации

FORMULATION SCREENING METHODS, APPARATUSES FOR PERFORMING SUCH METHODS AND FORMULATIONS FORMED BY SUCH METHODS

Номер: US20140045724A1
Автор: Selbo Jon
Принадлежит:

A method of screening for candidate compound-excipient combinations comprises dosing a compound into each receptacle of a collection of receptacles, dosing a first set of excipients and a second set of excipients into the receptacles wherein the dosing creates varying combinations of solutions of a first and second excipients within the receptacles, analyzing each receptacle for the presence of a precipitate, and classifying the receptacles based on the presence of a precipitate. 1. A method of screening for candidate compound-excipient combinations comprising:dosing a compound into each receptacle of a collection of receptacles;dosing a first set of excipients and a second set of excipients into said receptacles wherein said dosing creates multiple combinations of solutions of the first excipient set and the second excipient set within said receptacles;analyzing each receptacle for the presence of a precipitate; andclassifying the receptacles based on the presence of a precipitate.2. The method of wherein said compound is selected from the group consisting of an active pharmaceutical ingredient claim 1 , a nutraceutical claim 1 , or an agricultural active substance.3. The method of wherein said receptacle is a well plate claim 1 , a vial claim 1 , or a test tube.4. The method of wherein said receptacle is a well plate.5. The method of wherein said compound is dosed as a solid.6. The method of wherein said compound is dosed in an organic solvent.7. The method of wherein said compound and organic solvent form a solution.8. The method of wherein said receptacles are classified as either having precipitate or not having precipitate.9. The method of wherein said receptacles are classified based on the relative amount of precipitate present.10. The method of further comprising the step of removing the organic solvent prior to dosing with the first and second excipient sets.11. The method of wherein at least one set of excipients includes a set of polymers.12. The method ...

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Номер записи: 29
20-03-2014 дата публикации

In SItu Membrane Monitoring

Номер: US20140076030A1
Автор: Chilcott Terry Calvin, COSTER Hans Gerard Leonard
Принадлежит:

A method for in situ monitoring of a membrane of a membrane separation system comprises measuring a complex impedance of the membrane at a plurality of frequencies to provide an indication of the electrical conduction and electrical polarization properties of the membrane. The membrane based separation system for removing or reducing the concentration of materials carried in a fluid including a separation membrane has a first pair of electrodes separated by the membrane and arranged for measurement of the complex impedance of the membrane at a plurality of frequencies to provide the indication of the membrane properties. There may also be a second pair of electrodes separated by the membrane for injecting the stimulus current such that the injecting and monitoring functions are separated. 141-. (canceled)42. A method of in situ monitoring of a membrane separation system wherein the membrane separation system includes a separation membrane , and a pair of electrodes separated by the separation membrane , the method comprising:using the membrane separation system to separate a feed solution into a permeate and a residue, where the permeate passes through the separation membrane and the residue remains on a feed side of the separation membrane;applying an electrical alternating current stimulus through the separation membrane at one or more frequencies by applying the electrical stimulus between the pair of electrodes separated by the separation membrane;measuring a response electrical potential between the pair of electrodes separated by the separation membrane;comparing the electrical stimulus and the response electrical potential to determine a complex electrical impedance of the separation membrane at the one or more frequencies;determining electrical conduction and electrical polarization properties of the separation membrane from the complex electrical impedance of the separation membrane at the one or more of frequencies; andmonitoring changes of the electrical ...

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Номер записи: 30
10-04-2014 дата публикации

METHOD FOR DETERMINING WETTABILITY

Номер: US20140096628A1
Автор: Dyshlyuk Evgeny Nikolaevich
Принадлежит: SCHLUMBERGER TECHNOLOGY CORPORATION

Surface wettability of a material is determined by placing at least one sample of this material in at least one sealed calorimeter cell. Then a contact is provided of the at least one sample with a first wetting fluid and with a second wetting fluid at the same temperature and pressure. Heats of immersion are measured of the at least one sample in the first and the second wetting fluids and a wettability parameter is calculated for a solid/fluid/fluid system. 2. The method of claim 1 , wherein preliminary a contact between the first and the second wetting fluids is provided at the temperature and pressure of subsequent measurements of the heats of immersion.3. The method of claim 1 , wherein the surface area of the sample required for calculating the wetting parameter is determined by method of gas adsorption.4. The method of claim 1 , wherein the surface area of the sample required for calculating the wetting parameter is determined by a calorimeter using the Harkins-Jura method.5. The method of claim 1 , wherein the surface tension between the wetting fluids and the change of the surface tension with temperature is determined by the method of a rotating drop.6. The method of claim 1 , wherein the surface tension between the wetting fluids and the change of the surface tension with temperature is determined by the method of a sitting drop.7. The method of claim 1 , wherein a contact between the sample and the first wetting fluid is provided and the heat of immersion of the sample surface in the first fluid is measured claim 1 , then the sample surface is purified and a contact between the sample and the second wetting fluid is provided in the same cell of the calorimeter and the heat of immersion of the sample surface in the second fluid is measured.8. The method of claim 7 , wherein the sample is preliminary vacuum-processed.9. The method of claim 7 , wherein the sample is preliminary dried and purified.10. The method of claim 7 , wherein the cell with the sample ...

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Номер записи: 31
01-01-2015 дата публикации

Method and device for determining surface characteristics of stents, and stent defined surface characteristics

Номер: US20150000430A1
Автор: Arik Zucker, Armin W. MÄDER, Stefano Buzzi, Vincent Milleret
Принадлежит: Individual

A method and a device that determines surface characteristics of a stent to be implanted in a lumen in a body in which a wetting behavior of a stent surface serves as measure for the surface characteristics of the stent surface. In order to determine the wetting behavior, a course of a wetting force along a length of the stent surface is determined, the wetting power between the stent surface and a liquid surface being detected along the length of the stent.

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Номер записи: 32
06-01-2022 дата публикации

METHOD AND DEVICE FOR PHYSICOCHEMICAL CHARACTERIZATION OF MATERIALS

Номер: US20220003737A1
Автор: Antikainen Osmo, Ehlers Henrik, Räikkonen Heikki, Svanbäck Sami, Yliruusi Jouko
Принадлежит: The Solubility Company Oy

An analysis method and device including detecting at least one particle of matter in a fluid inside in a reaction chamber and correlating a change in the particle to a physicochemical property of the matter. 1. An analysis device comprisinga reaction chamber;at least one first inlet configured for passing at least one first fluid into the reaction chamber;at least one outlet configured for passing the at least one first fluid outside the reaction chamber;an immobilization zone arranged inside the reaction chamber configured to immobilize at least one particle; anda detection component capable of detecting changes in the at least one particle in the immobilization zone.2. The analysis device of claim 1 , wherein the at least one first inlet is configured for passing at least one second fluid into the reaction chamber claim 1 , the at least one outlet is configured for passing the at least one second fluid outside the reaction chamber and the immobilization zone is configured to immobilize at least one particle in at least one second fluid.3. The analysis device of claim 1 , wherein the detection component comprises a window arranged in a top plate claim 1 , bottom plate or in a wall defining the reaction chamber.4. The analysis device of claim 1 , wherein the detection component is integrated in a wall claim 1 , a top plate or a bottom plate of the device.5. The analysis device of claim 1 , wherein the immobilization zone comprises a permeable or semipermeable layer configured to receive the at least one particle via at least one second fluid.6. The analysis device of claim 1 , wherein the immobilization zone comprises a permeable or semipermeable layer configured to receive the at least one particle.7. A system comprising the analysis device of claim 1 , further comprising a fluid handling device for controlled passing of the at least one fluid through the analysis device claim 1 , the detection component capable of providing data about the at least one particle to ...

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Номер записи: 33
05-01-2017 дата публикации

METHOD FOR MEASURING DIFFUSION PERFORMANCE OF ACID DYE IN COLOR PASTE

Номер: US20170003211A1
Автор: Chen Feng, LONG Jiajie
Принадлежит:

The invention provides a method for measuring the diffusion performance of an acid dye in a color paste, comprising preparing a primary paste and placing the primary paste into a transparent cylindrical container; adding a dye to the primary paste formulate a color paste, and flatly and uniformly paving a layer of the color paste on an upper surface of the primary paste; performing constant-temperature treatment at 60-95° C. on the cylindrical container, so that the dye in the color paste on the top of the blank primary paste in the cylindrical container diffuses downwards to the bottom of the cylinder; and sampling the primary paste from a sampling hole, and diluting the sampled primary paste with deionized water. The method of the invention has simple operation steps, reliable and safe experiments, highly stable test data and good reproducibility of results, and high temperature and high pressure are not required herein. 2. The method for measuring the diffusion performance of an acid dye in a color paste as claimed in claim 1 , wherein the paste in the step A is selected from the group consisting of sodium alginate claim 1 , guar gum and carboxymethyl starch and any combination thereof.3. The method for measuring the diffusion performance of an acid dye in a color paste as claimed in claim 1 , wherein the primary paste in the step A contains an additive which is glycerol claim 1 , urea or ammonium sulphate claim 1 , the molar concentration of glycerol being 7.0×10molLto 5.0×10mol L claim 1 , the molar concentration of urea being 4.0×10mol Lto 1.5×10mol L claim 1 , and the molar concentration of ammonium sulphate being 1.0×10mol Lto 3.0×10mol L.4. The method for measuring the diffusion performance of an acid dye in a color paste as claimed in claim 3 , wherein the molar concentration of glycerol is 9.0×10mol Lto 3.0×10mol L claim 3 , the molar concentration of urea is 2.0×10mol Lto 1.0×10mol L claim 3 , and the molar concentration of ammonium sulphate is 0.5×10mol ...

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Номер записи: 34
07-01-2016 дата публикации

SYSTEM AND METHOD FOR RADIOSYNTHESIS, QUALITY CONTROL AND DOSE DISPENSING

Номер: US20160003791A1
Автор: Elizarov Arkadij, Lebedev Artem
Принадлежит:

A system and method for performing radiochemical synthesis, analysis and/or dispensing of radiopharmaceuticals using specially designed disposable components: palettes and caddies, the palette being an assembly of containers not connected with each other for direct material transfer; the caddy being a disposable component used to transfer material between containers on the palettes and/or other locations. 1. A system for performing a process selected from the group consisting of (a) radiopharmaceutical synthesis , (b) quality control tests of radiopharmaceuticals , (c) radiopharmaceutical dose dispensing , and (d) any combinations thereof , the system being configured to transfer a first quantity of one or more chemicals by picking up the first quantity of the one or more chemicals at a first location , transferring the first quantity of one or more chemicals to a second location and dropping off a second quantity of the one or more chemicals at a second location , wherein the first quantity is equal to or more than the second quantity.2. The system of claim 1 , wherein the system is for performing quality control tests of a radio-pharmaceutical product claim 1 , the system comprising:a holder having a plurality of containers, each configured to contain a reagent for performing a quality control test on the radio-pharmaceutical product, and in fluidic isolation from one another,wherein at least one of the plurality of containers contains a reagent different from another container.3. The system of claim 1 , wherein the system is for performing quality control tests of a radio-pharmaceutical product claim 1 , the system comprising:a palette comprising a plurality of containers, each of the containers comprising a reagent configured for reacting with the radio-pharmaceutical product and generating an optically detectable signal indicating a result of one of a plurality of quality control tests;wherein the quality control tests comprise at least two selected from the ...

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Номер записи: 35
04-01-2018 дата публикации

MEMS MICROTENSIOMETER

Номер: US20180003608A1
Автор: Lakso Alan N., Pagay Vinay, Santiago Michael, Sessoms David, Stroock Abraham D.
Принадлежит:

A device for measuring a chemical potential of a fluid in a plant tissue includes a cavity disposed within a sensor body as a liquid reservoir. The cavity is configured for containing therein a liquid, and the cavity including at least one opening. At least two porous membrane layers are positioned at least in part over the at least one opening of the cavity for selectively allowing water transfer between the plant fluid and the liquid in the cavity. At least one pressure sensor is configured for detecting changes in pressure of the liquid in the cavity. The changes are related to a chemical potential of the fluid in the plant tissue. 118-. (canceled)19. A device for measuring a chemical potential of a fluid in a plant tissue , said device comprising:a cavity disposed within a sensor body as a liquid reservoir, said cavity configured for containing therein a liquid, said cavity comprising at least one opening;at least two porous membrane layers positioned at least in part over said at least one opening of said cavity for selectively allowing water transfer between the plant fluid and the liquid in the cavity; andat least one pressure sensor configured for detecting changes in pressure of the liquid in said cavity, said changes are related to a chemical potential of the fluid in the plant tissue.20. The device according to claim 19 , wherein at least one of said at least two porous membrane layers comprises a reverse osmotic membrane or a nanoporous membrane.21. The device according to claim 19 , wherein said at least one pressure sensor comprises at least one piezoelectric transducer sensor or at least one strain gauge sensor.22. The device according to claim 19 , wherein said device comprises a Micro Electro-Mechanical System (MEMS).23. The device according to claim 19 , wherein said cavity is configured for being hydraulically connected to a vascular conduit of the plant claim 19 , via a space of the plant tissue claim 19 , wherein said chemical potential ...

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Номер записи: 36
02-01-2020 дата публикации

METHOD FOR OBSERVING SEBACEOUS GLAND

Номер: US20200003756A1
Автор: Ishizuka Shuta, Kurata Ryuichiro
Принадлежит: MANDOM CORPORATION

A method for observing a sebaceous gland, the method being useful for such applications as developing a cosmetic material or other external preparation, and including (I) a step for culturing, in a suspended state in a medium, a sebaceous gland structure in which the dermis and all or a portion of the subcutaneous tissue is removed from a skin tissue, and (II) a step for observing the cultured sebaceous gland structure obtained in step (I). 1. A method for observing a sebaceous , gland , comprising the steps of:I. culturing, in a suspended state in a medium, a sebaceous-gland-structure derived from a skin tissue, in which all or a portion of each of dermis and a subcutaneous tissue has been removed from the skin tissue, andII. observing the resulting cultured sebaceous-gland-structure in step I.2. The method for observing a sebaceous gland according to claim 1 , further comprising a step of removing all or the portion of each of the dermis and the subcutaneous tissue from an isolated skin tissue claim 1 , to obtain the sebaceous-gland-structure claim 1 , before carrying out the step I.3. A method for evaluating a sebum production-regulating action of a test substance claim 1 , comprising the steps of:A. culturing, in a suspended state in a medium in the absence of the test substance, a sebaceous-gland-structure derived from a skin tissue, in which all or a portion of each of dermis and a subcutaneous tissue has been removed from the skin tissue,B. culturing, in a suspended state in a medium in the presence of the test substance, a sebaceous-gland-structure derived from a skin tissue, in which all or a portion of each of dermis and a subcutaneous tissue has been removed from the skin tissue, andC. observing the resulting cultured sebaceous-gland-structure A in the step A and the resulting cultured sebaceous-gland-structure B in the step B, and evaluating the sebum production-regulating action of the test substance on the basis of difference in dynamics of the ...

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Номер записи: 37
07-01-2021 дата публикации

ANALYSIS METHOD OF 3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE BULK DRUG, TREATMENT FOR AMYOTROPHIC LATERAL SCLEROSIS, INHIBITION OF PROGRESSION OF AMYOTROPHIC LATERAL SCLEROSIS, AND METHOD OF PRODUCING DRUG CONTAINING 3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE BULK DRUG

Номер: US20210003544A1
Автор: SANO Aya, WAKASUGI Takeshi
Принадлежит: MITSUBISHI TANABE PHARMA CORPORATION

This method of analyzing the phenylhydrazine content in a 3-methyl-1-phenyl-2-pyrazolin-5-one bulk drug involves: obtaining a first measured value by measuring the phenylhydrazine content of a standard solution that contains phenylhydrazine or a salt thereof, a first acidic water and a first water-soluble organic solvent, and that exhibits a phenylhydrazine concentration of 0.01 μg/mL to 10 μg/mL; obtaining a second measured value by measuring the phenylhydrazine content in a sample solution that contains a 3-methyl-1-phenyl-2-pyrazolin-5-one bulk drug, a second acidic water and a second water-soluble organic solvent; and detecting the phenylhydrazine content in the 3-methyl-1-phenyl-2-pyrazolin-5-one bulk drug on the basis of the first measured value and the second measured value. The first acidic water is at least one type selected from hydrochloric acid, an aqueous acetic acid solution, and the like, the first water-soluble organic solvent is at least one type selected from acetonitrile and methanol, the second acidic water is at least one type selected from hydrochloric acid, an aqueous acetic acid solution, and the like, and the second water-soluble organic solvent is at least one type selected from acetonitrile, and methanol. 1. A method of analyzing the phenylhydrazine content in a 3-methyl-1-phenyl-2-pyrazolin-5-one bulk drug , which comprises:obtaining a first measured value by measuring the phenylhydrazine content in a phenylhydrazine standard solution that contains phenylhydrazine or a salt thereof, a first acidic water and a first water-soluble organic solvent, and that exhibits a phenylhydrazine concentration of 0.01 μg/mL to 10 μg/mL,obtaining a second measured value by measuring the phenylhydrazine content in a 3-methyl-1-phenyl-2-pyrazolin-5-one sample solution that contains a 3-methyl-1-phenyl-2-pyrazolin-5-one bulk drug, a second acidic water and a second water-soluble organic solvent, anddetecting the phenylhydrazine content in the 3-methyl-1- ...

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Номер записи: 38
13-01-2022 дата публикации

DETERMINING INTERFACIAL TENSION FOR FLUID-FLUID-SOLID ENVIRONMENTS

Номер: US20220011212A1
Автор: Engel Michael, Giro Ronaldo, Neumann Barros Ferreira Rodrigo, Steiner Mathias, Viana Ferreira Filipe
Принадлежит:

Aspects of the invention include determining, by a first AFM tip, a first snap-off force of a solid surface immersed in a first fluid, determining, by a second AFM tip, a second snap-off force, determining, by a third AFM tip, a third snap-off force, determining, by the first AFM tip, a fourth snap-off force of a droplet of the first fluid immersed in the second fluid on the solid surface, determining, by the second AFM tip, a fifth snap-off force, determining, by the third AFM tip, a sixth snap-off force, determining a first capillary force for first AFM tip and first droplet based on first snap-off force and fourth snap-off force, determining a second capillary force for second AFM tip and first droplet and a third capillary force for third AFM tip and first droplet, and determining interfacial tension between first fluid and second fluid based on the capillary forces. 1. A computer-implemented method comprising:using a processor to control an atomic force microscope (AFM) to make determinations; a first AFM tip having a first radius;', 'a second AFM tip having a second radius; and', 'a third AFM tip having a third radius; and, 'wherein the AFM comprises determining, by the processor operating the first AFM tip, a first snap-off force of a solid surface immersed in a first fluid;', 'determining, by the processor operating the second AFM tip, a second snap-off force of the solid surface immersed in the first fluid;', 'determining, by the processor operating the third AFM tip, a third snap-off force of the solid surface immersed in the first fluid;', 'determining, by the processor operating the first AFM tip, a fourth snap-off force of a first droplet of the first fluid deposited on the solid surface, wherein the first droplet, the first AFM tip, and the solid surface are immersed in a second fluid;', 'determining, by the processor operating the second AFM tip, a fifth snap-off force of the first droplet of the first fluid deposited on the solid surface, wherein the ...

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Номер записи: 39
11-01-2018 дата публикации

NMR-BASED SYSTEMS FOR CRUDE OIL ENHANCEMENT AND METHODS THEREOF

Номер: US20180011073A1
Автор: Cohen Tal, Rapoport Uri
Принадлежит: ASPECT INTERNATIONAL (2015) PRIVATE LIMITED

An NMR-based system () to analyze one or more of the following: (i) crude oil property, (ii) crude oil rheology of crude oil, comprising an NMR device () for providing time and/or batch resolved NMR analysis and/or crude oil rheological profile, said NMR having a crude oil inflow pipe (), and is in a fluid connection () with a crude oil refinery facility (); wherein said system further comprising a computer readable medium configured to store a retrievable crude oil NMR analysis and/or crude oil rheological profile of a desired crude oil product (standard crude oil product, SCOP), thereby providing said system means to compare NMR analysis and/or crude oil theological profile of said SCOP with said time or batch resolved crude oil. 1. An NMR-based system to analyze one or more of the following: (i) crude oil property , (ii) crude oil rheology of crude oil , comprising an NMR device for providing time and/or batch resolved NMR analysis and/or crude oil rheological profile , said NMR having a crude oil inflow pipe , and is in a fluid connection with a crude oil refinery facility; wherein said system further comprising a computer readable medium configured to store a retrievable crude oil NMR analysis and/or crude oil rheological profile of a desired crude oil product (standard crude oil product , SCOP) , thereby providing said system means to compare NMR analysis and/or crude oil rheological profile of said SCOP with said time or batch resolved crude oil.2. (canceled)3. (canceled)4. The NMR-based system of claim 18 , wherein said NMR comprises at least one first probe and at least one second probe claim 18 , thereby configuring said NMR to provide a time-resolved NMR analysis and/or rheological profile of crude oil flowing in said at least one first and at least one second probes claim 18 , concurrently or interchangeably.5. The NMR-based system of claim 4 , wherein said at least one second probe is configured to provide a time-resolved NMR analysis and/or rheological ...

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Номер записи: 40
14-01-2021 дата публикации

IN SITU, REAL-TIME IN-LINE DETECTION OF FILLING ERRORS IN PHARMACEUTICAL PRODUCT MANUFACTURING USING WATER PROTON NMR

Номер: US20210010962A1
Автор: TARABAN Marc B., YU Yihua (Bruce)
Принадлежит:

A method of using the transverse relaxation rate (R) of solvent NMR signal to detect filling errors of an alum-containing product in real-time in-line during manufacturing, for example during a fill-finish unit operation. This technique can be used for quality control in vaccine manufacturing to ensure the delivery of the correct concentration of alum-containing product to the product container such as a vial or pre-filled syringe. 1. A method of detecting a filling error of an alum-containing product in real-time in-line during a fill-finish unit operation , said method comprising:flowing the alum-containing product into a filling conduit, wherein the filling conduit directs the alum-containing product into a vial, and wherein the filling conduit is arranged to flow through a magnet and a probe of nuclear magnetic resonance (NMR) spectrometer prior to the vial;{'sub': '2,m', 'measuring the transverse relaxation rate of solvent Rin the alum-containing product flowing through the filling conduit; and'}{'sub': 2,m', '2,r', '2,r, 'comparing the measured Rto a reference transverse relaxation rate of solvent R, wherein the reference Rrepresents an acceptable flow rate or concentration of aluminum particles in the alum-containing product,'}{'sub': 2,m', '2,r, 'wherein when the measured Ris inside a range of the reference R, there is no filling error.'}2. The method of claim 1 , wherein the Ris measured using nuclear magnetic resonance (NMR).3. The method of claim 1 , wherein the filling conduit delivers product from an upstream large-scale product vessel to a product container.4. The method of claim 1 , wherein the Rcan be measured without withdrawing the alum-containing product from the filling conduit.5. The method of claim 1 , wherein the solvent is water.6. The method of claim 1 , wherein the alum-containing product comprises particles in a range from about 1 nanometer and 50 microns in diameter claim 1 , preferably about 500 nm to about 1000 nm or about 1000 nm to ...

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Номер записи: 41
14-01-2021 дата публикации

SYSTEMS AND METHODS FOR CHARACTERIZING SURFACTANT PROTEIN D (SP-D) OLIGOMERS

Номер: US20210010988A1
Автор: Manning Mark Cornell, Manning Ryan R., Rosenbaum Jan Susan
Принадлежит:

Some embodiments of the methods and compositions provided herein include identifying and/or quantifying oligomeric species of surfactant protein-D (SP-D). Some embodiments include performing an asymmetric flow field-flow fractionation with multi-angle laser light scattering (AF4-MALLS) analysis on the SP-D. 1. A method to determine the activity of a pharmaceutical composition comprising surfactant protein-D (SP-D) , the method comprising:measuring the relative proportion of oligomeric species of SP-D in the pharmaceutical composition; andcalculating the relative proportion of SP-D dodecamers in the pharmaceutical composition, thereby determining the activity of the pharmaceutical composition.259.-. (canceled) This application claims priority to U.S. Prov. App. No. 62/650,138 filed Mar. 29, 2018 entitled “METHODS FOR CHARACTERIZING SURFACTANT PROTEIN D (SP-D) OLIGOMERS” which is incorporated by reference herein in its entirety.The present application is being filed along with a Sequence Listing in electronic format. The Sequence Listing is provided as a file entitled AIRWY013WOSEQLIST, created Mar. 20, 2019, which is approximately 7 Kb in size. The information in the electronic format of the Sequence Listing is incorporated herein by reference in its entirety.Some embodiments of the methods and compositions provided herein include identifying and/or quantifying oligomeric species of surfactant protein-D (SP-D). Some embodiments include performing an asymmetric flow field-flow fractionation with multi-angle laser light scattering (AF4-MALLS) analysis on the SP-D.Mammalian pulmonary surfactant is a mixture of proteins (10%) and lipids (90%) including the major lipid component dipalmitoylphosphatidylcholine (Zuo Y Y, et al., Biochim Biophys Acta (2008) 1778:1947-77). The main function of the pulmonary surfactant is to ensure minimal surface tension within the lung to avoid collapse during respiration. Furthermore, by interacting with inhaled pathogens, the pulmonary ...

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Номер записи: 42
09-01-2020 дата публикации

ELECTROCHEMICAL OSMOLARITY OR OSMOLALITY SENSOR FOR CLINICAL ASSESSMENT

Номер: US20200011778A1
Автор: Cardinell Brittney, Honikel Mackenzie, LaBelle Jeffrey, Lin Chi, Penman Andrew, Smith Marcus, Youngbar Pierce
Принадлежит:

Osmolality and osmolality sensors and methods utilizing electrochemical impedance to detect changes in impedance to varying salinity concentrations. By way of example, the impedance reported at the specified frequency varies logarithmically with the concentration of sodium chloride subject to the sensor surface. Measurements obtained by the sensors and methods herein are utilized, for example, to differentiate between the clinical stages of dry eye disease (290-316 mOsm/L) to complement the current diagnostic procedures. Blood serum, urinalysis, and saliva also may be tested and the corresponding osmolarity or osmolality level evaluated for indications of a disease or condition. 1. A method for collecting and analyzing osmolarity in a bodily fluid , comprising:contacting an absorbent material on a sensor with said bodily fluid, wherein said sensor comprises a substrate and an electrode operably configured to provide an electrochemical impedance measurement of said bodily fluid, andmeasuring an electrochemical impedance of said bodily fluid to determine osmolarity.2. The method of claim 1 , wherein said bodily fluid is tear fluid.3. The method of claim 2 , further comprising detecting an indication of dry eye claim 2 , wherein dry eye is indicated by a measured osmolarity range of between 290-316 mOsm/L.4. The method of claim 3 , further comprising treating dry eye based on said osmolarity.5. The method of claim 4 , wherein said treating includes one or more of punctal occlusion claim 4 , meibomian gland therapy claim 4 , an ocular anti-inflammatory medication claim 4 , cyclosporine ophthalmic emulsion claim 4 , lifitegrast ophthalmic solution claim 4 , or hydroxypropyl cellulose ophthalmic drops.6salvia. The method of claim 1 , wherein said fluid is or urine.7. A method for analyzing osmolality in a bodily fluid sample claim 1 , comprising measuring an electrochemical impedance of said bodily fluid sample with a device to determine osmolality.8. The method of claim ...

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Номер записи: 43
09-01-2020 дата публикации

DETECTION ANALYZER

Номер: US20200011853A1
Автор: Wu Aiguo, YANG FANG
Принадлежит:

A detection analyzer including a first sample input/output element, a second sample input/output element, a sample compartment, a vibration platform, a vibration generator, a data acquisition system, a laser converter, and a data display. The first sample input/output element and the second sample input/output element are each connected to the sample compartment; the vibration platform is located inside the sample compartment; the vibration generator is located outside the sample compartment, and the vibration platform is connected to the vibration generator; the data acquisition system is located outside the sample compartment, and is connected to the vibration platform; and the data display is connected to the data acquisition system. 113- (canceled).14. A detection analyzer , comprising:a first sample input/output element, a second sample input/output element, a sample compartment, a vibration platform, a vibration generator, a data acquisition system, a laser converter, and a data display; wherein the first sample input/output element and the second sample input/output element are respectively in communication with the sample compartment; the vibration platform is located in the sample compartment; the vibration generator is located outside the sample compartment and the vibration platform is connected to the vibration generator; the data acquisition system is located outside the sample compartment and is connected to the vibration platform; and the data display is connected to the data acquisition system.15. The detection analyzer according to claim 14 , wherein the vibration platform is comprised of a pressure sensitive material or a vibrating quartz material.16. The detection analyzer according to claim 14 , wherein the edge of the vibration platform is fixedly connected to the circuit board by electronic elements claim 14 , and the circuit board is connected to an external vibration generator.1718. The detection analyzer according to claim 14 , wherein the ...

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Номер записи: 44
03-02-2022 дата публикации

DISSOLUTION DEVICE

Номер: US20220032283A1
Автор: Boyer Scott, GRILC Blaz, Hubinette Fredrik, MASCHER Erik, Planinsek Odon
Принадлежит: KLARIA PHARMA HOLDING AB

A dissolution device for measuring a dissolution rate of a test sample in a fluid, the device comprising a first cavity and a second cavity, wherein each of the first and second cavities has a fluid inlet for connection to a fluid supply, and wherein the device comprises an opening between the first and second cavities, and the device comprises a sample support configured to position the test sample across the opening. 1. A dissolution device for measuring a dissolution rate of a test sample in a fluid , the device comprising:a first cavity; anda second cavity;wherein each of the first and second cavities has a fluid inlet for connection to a fluid supply; andwherein the device comprises an opening between the first and second cavities, and the device comprises a sample support configured to position the test sample across the opening.2. The device of claim 1 , wherein the sample support comprises a permeable support configured to support the test sample across the opening.3. (canceled)4. The device of claim 1 , further comprising first and second fluid supplies claim 1 , wherein the first and second cavities are in fluid communication respectively with the first and second fluid supplies via the respective fluid inlets claim 1 , and wherein the first fluid supply is at a static pressure claim 1 , measurable at a point within the first cavity and adjacent the test sample claim 1 , that is equal to or higher than a static pressure of the second fluid supply claim 1 , measurable at a point within the second cavity and adjacent the test sample.5. The device of claim 4 , wherein at least one of the first and second fluid supplies is configured to be substantially free of pressure pulsation.6. The device of claim 4 , wherein the first and second fluid supplies are configured to produce a substantially constant relative pressure therebetween.7. The device of claim 4 , wherein the static pressure of at least one of the first and second fluid supplies is provided by a ...

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Номер записи: 45
15-01-2015 дата публикации

PARTICLE SUSPENSIONS USED AS LOW-CONTRAST STANDARDS FOR INSPECTION OF LIQUIDS

Номер: US20150015872A1
Автор: Chow Winfred Tee, Christiaanse Johannes G. M., KIRK Greg, Kole Francisco
Принадлежит:

In certain embodiments, a method for validating the human visual inspection process or an optical analysis instrument for use with biological particles may include inspecting a standard particle solution using the optical analysis instrument. The standard particle solution may include a known concentration of standard particles suspended in solution with the standard particles having a defined size and shape distribution. The standard particles may have a refractive index that is substantially similar to a refractive index of the biological particles. The method may include assessing a concentration of standard particles in the standard particle solution from the inspection. The method may include assessing a difference between the assessed concentration of standard particles and the known concentration of standard particles. The method may include modifying one or more parameters of the optical analysis instrument based on the assessed difference between the concentrations. The method may include assessing a detection efficiency of the optical analysis instrument. 1. A standard particle suspension for use with human visual inspection and/or with an optical analysis instrument , comprising:a solution; andone or more pluralities of standard particles suspended in the solution, wherein each plurality of standard particles has a defined size and shape distribution, and wherein the standard particles have a defined refractive index and a buoyancy that is substantially similar to biological particles.2. The suspension of claim 1 , wherein the refractive index of the standard particles ranges from values that render the standard particle transparent in solution to opaque in solution.3. The suspension of claim 1 , wherein the standard particles have a defined size distribution around a selected particle size.411. The suspension of claim 1 , wherein the selected standard particle size ranges from about nanometer to about millimeter.5. The suspension of claim 1 , wherein the ...

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Номер записи: 46
15-01-2015 дата публикации

Method for the evaluation of the colloidal stability of liquid biopolymer solutions

Номер: US20150015886A1
Автор: Patrick Garidel, Thomas Hennes, Torsten Schultz-Fademrecht
Принадлежит: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

The invention concerns the field of biomolecule formulation screening and stability testing. It concerns a method for the evaluation of the colloidal stability of liquid biopolymer solutions. The present invention describes a method for determining the stability of a liquid pharmaceutical composition comprising: a) providing a liquid pharmaceutical composition in a container, b) shaking said container on a shaker, whereby the shaker performs an oloid movement, c) determining the stability of said liquid pharmaceutical composition.

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Номер записи: 47
15-01-2015 дата публикации

SYSTEMS AND METHODS FOR DETERMINING INGREDIENT AMOUNTS FOR PREPARATIONS FOR ADMINISTRATION TO PATIENTS

Номер: US20150019138A1
Автор: Kaucky Dennis, Kober Darlene Marie, Leech Douglas, Tribble Dennis A., Zybczynski Elizabeth Ann
Принадлежит: BAXTER CORPORATION ENGLEWOOD

Computer systems and non-transitory computer readable media for determining an amount of an ingredient for a preparation for a requested therapy (e.g., an order or a prescription) includes an identifier, volume, and amounts of first and second compounds in each of a plurality of premix solutions. A predefined formulary comprising a formulary concentration of each of a plurality of additions is provided. A premix solution is selected. An amount of a first additions to be added to the premix solution may be selected. A number of bags of the premix solution, needed to satisfy a volume associated with the selected premix solution, are optionally reserved. An additive volume is determined at least by the specified first amounts of the first addition and a corresponding formulary concentration. 1. A method for determining an amount of an ingredient for preparation of a requested therapy to be administered to a patient , comprising: (i) an identifier for the respective premix solution,', '(ii) a volume of the respective premix solution in a prepackaged bag containing the premix solution, and, 'receiving a first selection of a premix solution from a plurality of premix solutions and an ordered amount of the premix solution, wherein each respective one of the premix solutions includes a predetermined description at least comprising(iii) an amount of a first component in the respective premix solution contained in the prepackaged bag;receiving a second selection, wherein the second selection includes a first amount of a first addition from a plurality of additions, wherein the plurality of additions are predefined in a formulary comprising at least one formulary concentration for each respective addition in the plurality of additions; and calculating a partial infusion factor based on the ordered amount and the volume of the premix solution in the prepackaged bag, wherein the partial infusion factor is determined by dividing the volume of the premix solution in the ...

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Номер записи: 48
18-01-2018 дата публикации

Method for detecting dissolution rate of preparation containing colloidal bismuth pectin

Номер: US20180017496A1
Автор: Anping LI, Feng CUI, Ping Zhu, Tai Zheng, Yuexia WU, Zhengguo QIN
Принадлежит: Shanxi Zhendong Ante Biopharmaceutical Co Ltd

A method for detecting a dissolution rate of a preparation containing colloidal bismuth pectin includes steps of: according to “ Pharmacopoeia of the People's Republic of China , 2010 Edition, Volume 2, Appendix XC”, dispersing the preparation containing the colloidal bismuth pectin into dissolution medium, and directly obtaining dissolution liquid; adding a protonic acid dissociation agent into the dissolution liquid until a hydrogen ion concentration reaches 0.8-1.2 mol/L; centrifuging for separating a supernatant; coloring the supernatant by adding a chromogen solution of citric acid or ascorbic acid and potassium iodide to obtain a test solution; calculating a dissolution amount, which is accounted by bismuth, of the colloidal bismuth pectin with a spectrophotometry method. The method of the present invention well detects dissolution curves and rates of the colloidal bismuth pectin in the preparation thereof, satisfying quality control requirements.

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Номер записи: 49
17-04-2014 дата публикации

MINIATURIZED FLOW-THROUGH CELL

Номер: US20140102177A1
Автор: KANG Lifeng, Kochhar Jaspreet Singh, MAH Choon Siong
Принадлежит:

The present disclosure relates to a diffusion cell for testing the permeation of a compound(s) across a membrane. Also, the present disclosure relates to a method of manufacturing a diffusion cell. Further, the present disclosure relates to a method of performing an assay using a diffusion cell. 1. A diffusion cell comprising:a donor compartment;a receptor compartment, wherein the receptor compartment comprises a first opening and a second opening;a tube, wherein the tube extends through a vertical axis of the receptor compartment, wherein the tube comprises a length, wherein the tube comprise a first end and a second end, wherein the first end of the tube extends through the first opening of the receptor compartment, wherein the second end of the tube extends through the second opening of the receptor compartment.2. The diffusion cell of claim 1 , wherein the tube comprises a split.3. The diffusion cell of claim 2 , wherein the donor compartment comprises a first end and a second end claim 2 , wherein the donor compartment comprises a cavity extending along a vertical axis of the donor compartment claim 2 , wherein the cavity of the donor compartment comprises a first end and a second end claim 2 , wherein the first end of the cavity of the donor compartment forms a first opening in the first end of the donor compartment claim 2 , and wherein the second end of the cavity of the donor compartment forms a second opening in the second end of the donor compartment.4. The diffusion cell of claim 3 , wherein the receptor compartment comprises a cavity claim 3 , wherein the cavity of the receptor compartment comprises an open end and a closed end.5. The diffusion cell of claim 4 , wherein the second end of the donor compartment is adjacent to the closed end of the cavity of the receptor compartment.6. The diffusion cell of claim 5 , wherein the second opening in the second end of the donor compartment is adjacent to the split of the tube.7. The diffusion cell of claim 1 , ...

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Номер записи: 50
17-01-2019 дата публикации

NANO-EXTENSIONAL RHEOMETER

Номер: US20190017913A1
Автор: Kress Oliver, Makowski Marcin, Ostapenko Tanya
Принадлежит:

For measuring rheological properties of a liquid sample, the sample is attached to two sample attachment surfaces opposing each other in a pulling direction. The sample attachment surfaces and the liquid sample attached thereto are arranged in a field of view of a light microscope and imaged onto an electronic camera by means of an objective lens of the light microscope. One of the two sample attachment surfaces is pulled away from the other one in the pulling direction, while a plurality of images of the sample attachment surfaces and the sample attached thereto are registered with the camera. For different distances of the two sample attachment surfaces, both a diameter of the liquid sample in a middle between the two sample attachment surfaces and the respective distances of the two sample attachment surfaces are determined from the images registered with the electronic camera during the step of pulling. 1. A method of measuring rheological properties of a liquid sample , the method comprising the steps ofattaching the liquid sample to two sample attachment surfaces opposing each other in a pulling direction;arranging the two sample attachment surfaces in a field of view of a light microscope;imaging the two sample attachment surfaces and the liquid sample attached thereto onto an electronic camera by means of an objective lens of the light microscope;pulling one of the two sample attachment surfaces away from the other of the two sample attachment surfaces in the pulling direction;registering a plurality of images of the two sample attachment surfaces and the liquid sample attached thereto with the electronic camera during the step of pulling; andfor different distances of the two sample attachment surfaces, determining both a diameter of the liquid sample in a middle between the two sample attachment surfaces and the respective distances of the two sample attachment surfaces from the plurality of the images registered with the electronic camera during the step ...

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Номер записи: 51
21-01-2021 дата публикации

DETERMINING WETTABLITY CHARACTERISTICS OF A FLUID-FLUID-SOLID SAMPLE

Номер: US20210018417A1
Автор: Engel Michael, Giro Ronaldo, Neumann Barros Ferreira Rodrigo, Steiner Mathias B.
Принадлежит:

Provided are embodiments for a system for determining wettability of fluid-fluid-solid systems. The system includes a confocal optical microscope and a storage medium, the storage medium being coupled to a processor. The processor is configured to perform a scan of a sample of a multi-phase system using the confocal optical microscope, wherein a phase defines a structural phase of matter, identify each phase of the sample, and measure a three-phase contact line for the sample, wherein the three-phase contact line is along an interface of first fluid and a second fluid and an interface of a second fluid and solid. The processor is configured to obtain one or more characteristics from the sample based at least in part on the three-phase contact line, and provide the one or more characteristics for the sample. Also provided are embodiments for a method for determining the wettability of fluid-fluid-solid systems. 1. A method for determining wettability of fluid-fluid-solid systems , the computer-implemented method comprising:performing, by a measuring device, a scan of a sample of a multi-phase system, wherein a phase defines a structural phase of matter, wherein the sample comprises a first fluid in a liquid phase, a second fluid in a liquid or gas phase, and a solid, wherein the first fluid forms a droplet in the sample;identifying each phase of the sample;measuring a three-phase contact line for the sample, wherein the three-phase contact line is along a two-phase interface between the first fluid and the second fluid, a two-phase interface between the first fluid and the second fluid, and a two-phase interface between the second fluid and the solid;obtaining, by a computing device, one or more figures-of-merit from the sample based at least in part on the three-phase contact line and each of the two-phase interfaces; andproviding, by the computing device, the one or more figures-of-merit from the sample.2. The method of claim 1 , further comprising loading a ...

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Номер записи: 52
21-01-2021 дата публикации

Determination of asphaltene solubility distribution

Номер: US20210018477A1
Автор: Birbal Chawla, Bridget E. Lang, Eric B. Sirota
Принадлежит: ExxonMobil Research and Engineering Co

Systems and methods are provided for determining an asphaltene solubility distribution for a petroleum sample and/or other hydrocarbon sample. A vessel for performing the method can include both packing material(s) and sidewall(s) that correspond to substantially inert materials. The vessel can initially contain a precipitating solvent suitable for causing precipitation of asphaltenes from a hydrocarbon sample. Examples of a precipitating solvents can correspond to n-heptane, toluene, and mixtures of n-heptane and toluene. The petroleum sample is then introduced into the vessel, along with a carrier solvent. The volume of the precipitating solvent can be large relative to the sample, so that the solubility of asphaltenes in the sample becomes dependent on the properties of the precipitating solvent. If asphaltenes are precipitated, the asphaltenes can be washed out of the column using a dissolution solvent. The asphaltenes washed out using the dissolution solvent can then be characterized to determine a total asphaltene content.

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Номер записи: 53
21-01-2021 дата публикации

SYSTEMS, DEVICES, AND METHODS FOR ULTRASONIC AGITATION MEDIATED KINETIC RELEASE TESTING OF COMPOUNDS

Номер: US20210018482A1
Автор: Acevedo Andrew J., Desai Darash, Holt Glynn R., Zaman Muhammad
Принадлежит:

Systems, devices, and methods for kinetic release testing of compounds are discussed herein. Ultrasonic agitation, with resultant cavitation and acoustic streaming, is used to breakdown and release drugs from one or more compounds to form a solution. The system uses small volumes of solvent to increase accessibility and portability of the system. Once dissolved, the solution is passed to a sampling system for calculating kinetic release behavior. The kinetic release behavior can be compared to existing reference data to identify the compound and/or confirm accurate manufacture by comparison of dissolution characteristics of the active ingredients. In some embodiments, streak photography and hydrophone measurements are used to study the effects of system parameters on the acousto-hydrodynamic environment. 1. A method for testing characteristics of a compound , the method comprising:combining the compound with a solvent to form a sample or the utilizing the compound alone in the case of liquid or syrup formulations;activating a sonicator to agitate the sample to transform the sample into a solution;sampling the solution at a plurality of time intervals;determining kinetic release behavior of the compound in solution as a function of data related to the samplings;comparing the data of the samplings with a reference data set of kinetic release behavior of the compound to form a result; andproducing an output based on the result.2. The method of claim 1 , wherein the sampling occurs during agitation of the sample.3. The method of claim 1 , further comprising coupling the sonicator to a horn for agitating the sample to transform the sample into the solution.4. The method of claim 3 , further comprising adjusting one or more of an amplitude setting of the sonicator claim 3 , frequency of applied ultrasonic signal claim 3 , diameter of the horn claim 3 , and geometry of the horn to change a rate of transformation of the sample into the solution.5. The method of claim 3 , ...

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Номер записи: 54
21-01-2021 дата публикации

APPARATUS AND METHOD FOR MEASURING DEGRADATION KINETICS OF A BIOMATERIAL IN AQUEOUS SOLUTION BELOW THE NORMAL FREEZING TEMPERATURE

Номер: US20210018485A1
Автор: DE BRITO ESTRELA Rui, GIL SENA REGO Pedro, SILVESTRE DUARTE Andreia Filipa
Принадлежит:

This present disclosure describes an apparatus and a method for measuring degradation kinetics of a biomaterial in aqueous solution below the normal freezing temperature. Further includes new systems comprising high-pressure containers with nucleating-locks, a temperature-control holder for the high-pressure containers, a holder for the nucleating-locks and an insulated low-temperature gradient chamber. A method is described comprising several steps such as filling of the high-pressure container with the biomaterial solution to be slightly below freezing temperature, closing of the container with a nucleating-lock, which is below freezing temperature, allowing the container to reach the reaction temperature, removing the container at selected time and bringing it to above freezing temperature and opening the container to recover the biomaterial solution. 1. A method for measuring degradation kinetics of a biomaterial in aqueous solution , comprising the steps of:filling a high-pressure container with the biomaterial in aqueous solution and submitting said biomaterial to a temperature below the freezing temperature of the biomaterial at atmospheric pressure;closing the high-pressure container with a nucleating-lock, wherein the nucleating-lock is at a temperature below the freezing temperature of the biomaterial at atmospheric pressure;allowing the high-pressure container to reach a pre-determined temperature different from the freezing temperature of the biomaterial at atmospheric pressure;removing the high-pressure container at a selected time and placing it at a temperature higher than the freezing temperature of the biomaterial at atmospheric pressure; andopening the high-pressure container for recovering the biomaterial in aqueous solution for complementary analytic characterization,wherein the degradation kinetics of the biomaterial in aqueous solution is measured at a temperature below the freezing temperature of the biomaterial at atmospheric pressure.2. The ...

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Номер записи: 55
26-01-2017 дата публикации

Slippery Anti-Fouling Surfaces Fabricated from Reactive Polymer Multilayers

Номер: US20170022371A1
Автор: CARTER Matthew, LYNN David, MANNA Uttam
Принадлежит: WISCONSIN ALUMNI RESEARCH FOUNDATION

This invention provides slippery liquid-infused porous surfaces (SLIPS) using nanoporous or microporous and chemically reactive polymer multilayers. This approach permits fabrication of slippery anti-fouling coatings on complex surfaces and provides new means to manipulate the mobilities of contacting aqueous fluids. The results expand the range of tools that can be used to manipulate the behaviors of SLIPS and open the door to new applications of this emerging class of soft materials. 1. A method for fabricating a nanoporous or microporous slippery liquid-infused porous surface (SLIPS) multilayer film on a substrate , wherein said multilayer film comprises one or more bilayers , said method comprising the steps of:a) exposing the surface of the substrate to a first solution comprising a first polymer wherein a layer of the first polymer is deposited on at least a portion of the substrate;b) exposing the substrate to a second solution comprising a second polymer wherein the second polymer reacts with the first polymer layer and a layer of the second polymer is deposited on at least a portion of the first polymer layer, thereby forming a bilayer having nanoscale porosity or microscale porosity in the multilayer film; andc) exposing the substrate to an oil wherein said oil coats at least a portion of the multilayer film and said oil at least partially fills the pores of at least a portion of said multilayer film.2. The method of further comprising the step of patterning the substrate so that the multilayer film is formed on a first specified portion of the substrate and a second specified portion of the substrate is not covered by the oil infused multilayer film.3. The method of further comprising the step of functionalizing a portion of the one or more bilayers on the first specified portion of the substrate with an amine claim 2 , hydroxyl group claim 2 , thiol group claim 2 , or hydrazine group having the formula R—NH claim 2 , R—OH claim 2 , R—SH or R—NHNH claim 2 ...

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Номер записи: 56
26-01-2017 дата публикации

QUANTITATION OF TAMOXIFEN AND METABOLITES THEREOF BY MASS SPECTROMETRY

Номер: US20170023537A1
Автор: Clarke Nigel
Принадлежит:

Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of norendoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and tamoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, norendoxifen, and other tamoxifen metabolites. 1. A method for determining the amount of norendoxifen in a human sample by mass spectrometry , comprising:(a) purifying the sample by liquid chromatography;(b) ionizing said norendoxifen to produce one or more norendoxifen ions detectable by mass spectrometry;(c) detecting the amount of the norendoxifen ion(s) from step (b) by mass spectrometry;wherein the amount of the ion(s) detected is related to the amount of norendoxifen in said sample,wherein the method has a limit of quantitation of less than or equal to 5 ng/mL.2. The method of claim 1 , further comprising protein precipitation prior to step (a).3. The method of claim 1 , further comprising filtration prior to step (a).4. The method of claim 1 , wherein said liquid chromatography is high pressure liquid chromatography (HPLC).5. The method of claim 1 , wherein said liquid chromatography is high turbulence liquid chromatography (HTLC).6. The method of claim 1 , further comprising detecting the amount of an internal standard.7. The method of claim 5 , wherein said internal standard is a N-Desmethyl-4-Hydroxy Tamoxifen-d5.8. The method of claim 1 , wherein said ionization is by atmospheric pressure chemical ionization (APCI).9. The method of claim 1 , wherein said ionization is by electrospray ionization (ESI).10. The method of claim 1 , wherein said ionization is in positive ion mode.11. The method of claim 1 , wherein said sample is a serum or plasma sample.12. The method of claim 1 ...

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Номер записи: 57
25-01-2018 дата публикации

SHORT-WAVE INFRARED SUPER-CONTINUUM LASERS FOR NATURAL GAS LEAK DETECTION, EXPLORATION, AND OTHER ACTIVE REMOTE SENSING APPLICATIONS

Номер: US20180024104A1
Автор: Islam Mohammed N.
Принадлежит:

A measurement system performs non-destructive quality control or constitutive analysis using a light source generating an output optical beam using semiconductor sources that generate an input optical beam, a multiplexer configured to receive the input beam and to form an intermediate optical beam, and fibers configured to receive the intermediate beam and to form the output beam. The fibers include a fused silica fiber having a core diameter less than 400 microns. The output beam includes wavelengths between 700 and 2500 nanometers and has a bandwidth of at least 10 nanometers. The system includes a measurement apparatus that receives the output beam and delivers the beam to a sample to generate a spectroscopy beam. A receiver is configured to receive the spectroscopy beam and process the beam to generate an output signal. The light source and receiver are remote from the sample, which includes plastics or food industry goods. 1. A measurement system comprising: a plurality of semiconductor sources configured to generate an input optical beam;', 'a multiplexer configured to receive at least a portion of the input optical beam and to form an intermediate optical beam;', 'one or more fibers configured to receive at least a portion of the intermediate optical beam and to form the output optical beam;', 'wherein at least a portion of the one or more fibers comprises a fused silica fiber having a core diameter less than 400 microns;', 'wherein the output optical beam comprises one or more optical wavelengths, at least a portion of which are between 700 nanometers and 2500 nanometers; and', 'wherein the output optical beam has a bandwidth of at least 10 nanometers;, 'a light source configured to generate an output optical beam, comprisinga measurement apparatus configured to receive a received portion of the output optical beam and to deliver a delivered portion of the output optical beam to a sample, wherein the delivered portion of the output optical beam is configured ...

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Номер записи: 58
10-02-2022 дата публикации

METHODS OF GENERATING ORGANOIDS FOR HIGH THROUGHPUT SCREENING OF DRUGS

Номер: US20220042975A1
Автор: AYYASH Muneef, EHRLICH Avner, Nahmias Yaakov
Принадлежит: YISSUM Research Development Company of the Hebrew University of Jerusalem LTD.

Methods of generating organoids on multi-well plates are provided by depositing a polymeric solution comprising cells under conditions which result in a homogenous population of organoids, which can be used for high throughput analysis for drug screening and for determining treatment regimens of a drug. 1. A method of determining a dose range of a pharmaceutically active agent to be administered for treating a disease or condition , the method comprising:incubating a plurality of organoids with a respective plurality of different concentrations of said agent;monitoring function of said organoids over a time period to determine, for each organoid, a time-to-onset (TTO) of a response of said organoid to said agent, thereby providing a plurality of TTO values, one for each of said concentrations;fitting said plurality of TTO values to an asymptotic function;extracting an asymptotic value from said asymptotic function; anddetermining a range of a dose amount based on said extracted asymptotic value.2. The method of claim 1 , wherein said monitoring is in the absence of flow of said agent to and from said organoids.3. (canceled)4. The method of claim 1 , wherein said incubating is within bioreactors under condition of a steady flow of said agent to said organoids.5. The method according to claim 1 , wherein said monitoring said function claim 1 , comprises monitoring oxygen levels.6. The method according to claim 5 , wherein said organoids are embedded with oxygen sensors claim 5 , and wherein said monitoring said oxygen levels comprises monitoring signals emitted by said oxygen sensors.78-. (canceled)9. The method according to claim 1 , wherein said asymptotic function claim 1 , is selected from the group consisting of: an asymptotically decaying function claim 1 , an exponential function and a non-exponential function.1011-. (canceled)12. The method according to claim 1 , wherein said determining the dose range comprises selecting a dose range such that a peak plasma ...

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Номер записи: 59
24-01-2019 дата публикации

RESONANTLY-DRIVEN DROP CONTACT-LINE MOBILITY MEASUREMENT

Номер: US20190025177A1
Автор: STEEN Paul H., XIA Yi
Принадлежит: CORNELL UNIVERSITY

The present disclosure relates to, inter alia, systems and methods for measuring contact-line mobility of a liquid on a solid substrate. The system includes a motion-generation component, a motion-measurement component, and a computer component. The motion-generation component can include an actuator and a controller, the actuator being adapted to mount a solid substrate and effective to impart periodic forcing to the solid substrate when a test droplet of the liquid is deposited thereon, and the controller being adapted to tune frequency and amplitude of the forcing to induce measurable contact-line displacement of the test droplet on the solid substrate. The motion-measurement component includes an image acquisition device adapted for capturing images of the test droplet. The image acquisition device has requisite spatial and temporal resolution to enable acquisition of image data of the test droplet, the image data including contact-line displacement, contact-line speed, and contact angle at or near contact-line. 1. A system for measuring contact-line mobility of a liquid on a solid substrate , wherein said system comprises: (i) said actuator adapted to mount a solid substrate, and effective to impart periodic forcing to the solid substrate when a test droplet of the liquid is deposited thereon; and', '(ii) said controller is adapted to tune frequency and amplitude of the forcing to induce measurable contact-line displacement of the test droplet on the solid substrate;, '(a) a motion-generation component comprising an actuator and a controller, wherein(b) a motion-measurement component comprising an image acquisition device adapted for capturing images of the test droplet deposited on the solid substrate before, during and/or after the forcing imparted by the actuator, said image acquisition device having requisite spatial and temporal resolution to enable acquisition of image data of the test droplet comprising contact-line displacement, contact-line speed, and ...

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Номер записи: 60
24-01-2019 дата публикации

METHOD AND APPARATUS FOR INDETIFICATION OF COUNTERFEIT DRUGS, PHARMACEUTICALS, OR MEDICINES

Номер: US20190025219A1
Автор: Koulikov Serguei
Принадлежит:

Systems and methods for measuring the isotope ratio of one or more gaseous oxides produced during combustion of drugs, pharmaceuticals, or medicines aiming to detect counterfeit drugs, pharmaceuticals, or medicines based on comparison of the isotopic composition of the tested drugs, pharmaceuticals, or medicines with the isotopic composition of the authentic products. 1) A method of determining counterfeit drugs , pharmaceuticals , or medicines , the method comprising of the steps of: a) converting the drugs , pharmaceuticals , or medicines into gaseous oxides by combustion with oxygen with known isotopic composition; b) delivering said gaseous oxides to an optical absorption spectroscopy based isotopic ratio gas analyzer; c) measuring isotopic composition of at least one of the following gaseous oxides: CO , CO , NO , NO , NO , HO , HO , SO , SO , ClO; d) comparing the measured isotopic composition of said gaseous oxides with the isotopic composition of said gaseous oxides produced by combustion of an authentic product.2) The method of claim 1 , wherein a source of oxygen with known isotopic composition is a zero air made from the ambient air.3) The method of claim 1 , further including measuring the amount of one or more said gaseous oxides formed through the combustion process.4) The method of claim 1 , further including dilution of said gaseous oxides formed through the combustion process by a balance gas.5) The method of claim 1 , wherein converting drugs claim 1 , pharmaceuticals claim 1 , or medicines in liquid form includes removing a solvent from drugs claim 1 , pharmaceuticals claim 1 , or medicines in liquid form claim 1 , and converting their residuals into gaseous oxides by combustion.6) The method of claim 1 , wherein conversation of drugs claim 1 , pharmaceuticals claim 1 , or medicines in liquid form includes removing a solvent from drugs claim 1 , pharmaceuticals claim 1 , or medicines in liquid form claim 1 , and converting the solvent into gaseous ...

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Номер записи: 61
23-01-2020 дата публикации

Vitro Method and Apparatus for Analysing the Behaviour of Substances in Simulated Physiological Environment

Номер: US20200025664A1
Автор: JERE Dhananjay Jagdish, Mahler Hanns-Christian, Patel Sulabh
Принадлежит:

The invention refers to an in vitro method and apparatus for analysing the behaviour of substances in simulated physiological environment. The method comprises the steps of providing a first fluid, a gel matrix and a second fluid, separating the first fluid and the gel matrix by at least one first semi-permeable membrane and separating the gel matrix and the second fluid by at least one second semi-permeable membrane. The method further comprises the steps of injecting a substance into the first fluid, letting the substance migrate from the first fluid through the at least one first semi-permeable membrane, through the gel matrix, through the at least one second semi-permeable membrane and into the second fluid, and determining clearance of the substance from the first fluid. 121.-. (canceled)22. An apparatus for analyzing the behaviour of molecules in simulated physiological environment , the apparatus comprisinga first compartment for receiving a first fluid,a second compartment for receiving a gel matrix, anda third compartment for receiving a second fluid; the apparatus further comprisingat least one first semi-permeable membrane, andat least one second semi-permeable membrane, the at least one second semi-permeable membrane being arranged at a distance from the at least one first semi-permeable membrane, whereinthe at least one first semi-permeable membrane is arranged between the first compartment and the second compartment, and wherein the at least one second semi-permeable membrane is arranged between the second compartment and the third compartment.23. The apparatus according to claim 22 , wherein the first compartment claim 22 , the second compartment and the third compartment are arranged in a row claim 22 , and wherein the at least one first semi-permeable membrane and the at least one second semi-permeable membrane are arranged substantially vertically between the respective compartments.24. The apparatus according to claim 22 , further comprising ...

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Номер записи: 62
28-01-2021 дата публикации

Experimental Device for Measuring Diffusion Coefficient of Natural Gas

Номер: US20210025801A1
Автор: Jiayi Zhang, Shuyong Hu, Tingting Qiu
Принадлежит: SOUTHWEST PETROLEUM UNIVERSITY

The present invention discloses a new experimental device for measuring a diffusion coefficient of natural gas, mainly including a new core holder, a differential pressure sensor, pressure gauges, multiport valves, a confining pressure pump, a vacuum pump, a hydrocarbon gas source, a nitrogen gas source, a gas chromatograph, an intermediate container, sample chambers, a pressure stabilizing device, and pressure-sensitive alarm devices. A rubber sleeve of the new core holder can prevent a core from being stuck in the holder during core replacement due to an improper operation. The configured pressure stabilizing device is connected to the sample chambers, to ensure stable internal pressure in the chambers after sampling. In this way, one experimental variable is omitted, and an experimental result is more accurate and reliable. If gas leakage occurs. A sensor device can sense the gas leakage in time and sends an alarm to a mobile device of an experimenter.

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Номер записи: 63
04-02-2016 дата публикации

PORTABLE SENSORS FOR DETERMINATION OF LIQUID SURFACE TENSION, AND METHODS OF USES THEREOF

Номер: US20160033383A1
Автор: FALDE Eric, Grinstaff Mark W., Yohe Stefan
Принадлежит:

The present invention relates to the measurement of liquid surface tension using a small, portable sensor. More specifically, the present invention relates to a sensor on which a droplet of the sample liquid is placed and quickly either wets and changes color or remains non-wetted for several minutes. The detection range of this type of sensor is tunable to surface tensions useful for detecting surfactant levels in water, biological liquids, and other liquids, making it useful for a variety of medical, veterinary, home-care, environmental, and global health applications. 1. A method of determining surface tension of a fluid sample comprising:a. contacting the fluid sample with a selectively wetting layer of a surface tension sensor, wherein the surface tension sensor comprises the selectively wetting layer and an indicator layer, the selectively wetting layer comprising a roughened and/or porous structure tuned to a pre-determined critical wetting surface tension (CWST), and the indicator layer comprising a hydrophilic material and a detectable agent, wherein the detectable agent generates a detectable signal upon wetting of the indicator layer;b. detecting a detectable signal from the indicator layer; and 'determining surface tension of the fluid sample to be at or above the pre-determined CWST if a detectable signal from the indicator layer is absent.', 'c. determining surface tension of the fluid sample to be below the pre-determined CWST if a detectable signal from the indicator layer is present; or'}2. The method of claim 1 , wherein the selectively wetting layer comprises microfibers.3. The method of claim 2 , wherein the microfibers have a diameter of about 1 μm to about 10 μm.4. The method of claim 1 , wherein the pre-determined CWST is characterized by a non-wetted or partially wetted state to a wetted state within a range of about 1-2 mN/m claim 1 , 2-3 mN/m claim 1 , or 3-4 mN/m.5. The method of claim 1 , wherein the predetermined CWST is between 25 and ...

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Номер записи: 64
04-02-2016 дата публикации

METHODS FOR DETERMINING ACTIVE INGREDIENTS OF AN HERBAL MEDICINE, SOURCES OF AND CATALYTIC PATHWAYS FOR PRODUCTION THEREOF

Номер: US20160033464A1
Автор: ZHANG Zongchao
Принадлежит:

Disclosed are methods for determining active ingredients of herbal medicines including identifying organic sources and catalytic (mineral) pathways to produce such active ingredients. 1. A method comprising:a) utilizing an herbal medicine comprising at least one herb comprising cellulosic material and minerals, wherein said cellulosic material comprises organic components;b) analyzing each of said herbs of said herbal medicine to identify and quantify an analyte selected from the group consisting of: i) said minerals, ii) the elements: C, H, N, O, S, B, P, and halides, iii) said organic components, and iv) combinations thereof;c) contacting a portion of each of said herbs of said herbal medicine with portions of a solvent to remove any of said minerals removable by said solvent thereby forming mineral-reduced herbs;d) analyzing each of said mineral-reduced herbs to identify and quantify non-removable minerals not removed in step c);e) decocting a portion of each of said herbs in a portion of an aqueous solution comprising water to form individual herb liquors;f) decocting a portion of each of said mineral-reduced herbs in a portion of said aqueous solution to form individual mineral-reduced herb liquors;g) contacting a portion of said herbal medicine comprising each of said herbs with a portion of said solvent to remove any of said minerals removable by said solvent to form a mineral-reduced herbal medicine;h) decocting a portion of said herbal medicine comprising each of said herbs in a portion of said aqueous solution to form an herbal medicine liquor;i) decocting a portion of said mineral-reduced herbal medicine in a portion of said aqueous solution to form a mineral-reduced herbal medicine liquor;j) performing medicinal efficacy testing for each of said individual herb liquors, each of said individual mineral-reduced liquors, said herbal medicine liquor, and said mineral-reduced herbal medicine liquor; andk) comparing the medicinal efficacies of the liquors ...

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Номер записи: 65
01-05-2014 дата публикации

METHODS FOR TESTING AND ASSESSING ASPHALT CONCRETE MIXTURE WORKABILITY AND COMPACTABILITY

Номер: US20140116116A1
Автор: Dongre Rajendra Nidhish
Принадлежит: Pine Instrument Company

Methods of design, testing and quality control for asphalt concrete pavement mixtures. 1. A method for determining a material characteristic of asphalt concrete mixtures , the method comprising:heating an asphalt concrete mixture contained in a molding apparatus to a first temperature;placing the mixture into the molding apparatus, the molding apparatus having at least one moveable end plate;applying a force to the mixture via the end plate at a predetermined loading rate and to a first force and to a second force;measuring and recording the applied forces and heights of the mixture in the molding apparatus during the application of the forces, anddetermining a material characteristic of the mixture by calculating a force, height relationship of the asphalt concrete mixture at the first and second force levels.2. The method of further comprising the step of determining a strain of the asphalt concrete mixture based on the measured heights of the mixture in the molding apparatus during the application of forces.3. The method of further comprising the step of determining a material characteristic of the asphalt concrete mixture by calculating a slope of a stress-strain relationship of the asphalt concrete mixture at the first and second stress levels.4. The method of wherein the determined material characteristic is workability.5. The method of wherein the determined material characteristic is compactability.6. The method of wherein the strain is determined as a volumetric strain based on an initial height at a predetermined stress level.7. The method of wherein molding apparatus is a Superpave Gyratory Compactor.8. The method of wherein the loading rate is constant.9. The method of wherein the loading rate is a constant strain rate of the material specimen.10. The method of wherein the loading rate is varied throughout a material stress range.11. The method of further comprising the steps of testing the asphalt concrete mixture with and without compaction aids to ...

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Номер записи: 66
01-02-2018 дата публикации

ASSEMBLY FOR ASSESSING DRUG PERMEABILITY WITH ADJUSTABLE BIOMIMETIC PROPERTIES

Номер: US20180031465A1
Автор: Bauer-Brandl Annette, Di Cagno Massimiliano Pio
Принадлежит:

There is provided an assembly and process for its preparation for predicting the permeability of chemical compounds, comprising a donor compartment for adding a composition comprising the compound; a barrier based on a support and a phospholipid layer adhering to the support; and an acceptor compartment for accepting the compound upon permeation of the barrier. 1. A barrier assembly , for determining permeability of one or more chemical compounds across a biological barrier , the barrier assembly comprising:a donor compartment for adding the chemical compound or a composition comprising the compound;an acceptor compartment for accepting the compound upon permeation across a barrier; anda barrier separating the donor compartment and acceptor compartment;wherein said barrier comprises a polymeric support, a phospholipid layer adhering to the surface of the polymeric support, and a cover layer on top of the phospholipid layer.240-. (canceled)41. The barrier assembly according to claim 1 , wherein the thickness of the polymeric support ranges from 0.1-300 μm.42. The barrier assembly according to claim 1 , wherein the thickness of the phospholipid layer ranges from 0.1-300 p.m.43. The barrier assembly according to claim 1 , wherein the phospholipid layer is present in an amount of 0.05-10 mg/cm2 on the surface of the polymeric support.44. The barrier assembly according to claim 1 , wherein the polymeric support comprises cellulose claim 1 , cellulose acetate claim 1 , cellulose nitrate claim 1 , cellulose hydrate claim 1 , hydrophilic mixed cellulose esters claim 1 , polyamides claim 1 , polyethylene claim 1 , polypropylene claim 1 , polyurethane claim 1 , polyethylenterephthalate claim 1 , polyvinylfluoride claim 1 , polyvinylchloride claim 1 , polyvinylidendifluoride claim 1 , polytetrafluoroethylen claim 1 , polysulfones claim 1 , a hydrophilic polyethersulfone claim 1 , polycarbonate claim 1 , or cellulose hydrate.45. The barrier assembly according to claim 1 , ...

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Номер записи: 67
05-02-2015 дата публикации

Method and Device for Determining Solid Particle Surface Energy

Номер: US20150033833A1
Автор: Bikkina Prem Kumar, Gomez Luis Eduardo, Kouba Gene Edward, Mohan Ram S., Shoham Ovadia, Subramani Hariprasad Janakiram
Принадлежит:

A method of determining solid particle surface energy includes placing solid particles in a container made of a very high surface energy material and pouring a liquid into the container. The method further includes tilting the container to drain out from the container a first subset of the solid particles floating at a top surface of the liquid and tilting the container to move the liquid away from a second subset of the solid particles that are below the top surface. The method also includes tilting the container to move the liquid back toward the second subset of the solid particles such that at least a portion of the second subset of particles floats at the top surface of the liquid and tilting the container to drain out from the container the portion of the second subset of the solid particles now floating at the top surface of the liquid. 1. A method of determining solid particle surface energy , the method comprising:placing solid particles in a container made of a very high surface energy material;pouring a liquid into the container;tilting the container to drain out from the container a first subset of the solid particles floating at a top surface of the liquid;tilting the container to move the liquid away from a second subset of the solid particles that are below the top surface;tilting the container to move the liquid back toward the second subset of the solid particles such that at least a portion of the second subset of particles floats at the top surface of the liquid; andtilting the container to drain out from the container the portion of the second subset of the solid particles now floating at the top surface of the liquid.2. The method of claim 1 , further comprising repeating the steps of tilting the container to move the liquid away from the second subset of the solid particles claim 1 , tilting the container to move the liquid back toward the second subset of solid particles claim 1 , and tilting the container to drain out from the container the ...

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Номер записи: 68
17-02-2022 дата публикации

Application of the apparent volume of distribution in extraction technologies and pharmacokinetics

Номер: US20220050094A1
Автор: Savva Michalakis
Принадлежит:

The present invention relates to the discovery of the apparent volume of distribution as an intensive physical property of matter and its use in the field of chemical separation sciences and pharmacokinetics. The invention provides various methods of determining the amount of substance in all phases, substance concentration in all phases, extraction efficiency, solvent capacity, phase volume needed to achieve a given extraction efficiency, the substance's apparent volumes of distribution with respect to each phase in the system and the partition coefficient or distribution ratio that defines the partitioning of the substance between two phases that are in contact. In the field of pharmacokinetic multiphasic compartment models the invention provides methods to determine the substance amount in the body from measured plasma substance concentration at all times in the one-compartment model and at times of momentary distribution equilibrium of the substance (t) in multi-compartment models. 2. The exclusive use of the apparent volume of distribution in multiphasic compartment models composed of kinetically different compartments with respect to the rate of drug uptake/release , where each compartment can be composed of one or more phases and each phase can have the same or different drug affinity.3. That compartment volumes as determined by regression analysis of experimental data in classical pharmacokinetic compartment models , where each compartment may be composed of one or more phases , represent real physiologically relevant body fluid volumes accessible by a substance. Ser. No. 16/992,658Not Applicable.Not Applicable.Not Applicable.The literature is abundant with hundreds of different “definitions” for the volume of distribution e.g., a mathematical ratio, a fudge factor, a proportionality constant, an ideal, hypothetical, theoretical, imaginary or apparent volume that has no direct anatomical or physiological meaning but somehow it relates the drug concentration ...

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Номер записи: 69
04-02-2021 дата публикации

Apparatus buffer and method for ph control

Номер: US20210033588A1
Автор: Andrew Curl, Dean Fitzgerald, Fang Liu
Принадлежит: University of Hertfordshire

An apparatus, buffer solutions and a method are provided for pH control of in vitro dissolution tests used to monitor the drug release rate from solid unit dosage forms which are used to predict their in vivo effects or for quality control purposes. A method of preparing a continuous condition and a clear bicarbonate ion based solution for in vitro dissolution testing of pharmaceutical products is also provided. An enclosure device is also provided for use in the provision of pH control and stabilization to a bicarbonate based solution used in the in vitro dissolution testing of pharmaceutical products.

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Номер записи: 70
31-01-2019 дата публикации

ANALYSIS METHOD AND ANALYSIS DEVICE

Номер: US20190034597A1
Автор: Noguchi Shintaro, OTA Chikashi, Tsumoto Kouhei
Принадлежит:

Raman spectra of protein solutions having a plurality of concentrations are acquired. An index, which changes according to interaction between protein molecules, is calculated based on a predetermined peak included in the Raman spectra. A threshold of concentration at which protein can be denatured is specified based on change in the index against change in concentration. The threshold is compared with a concentration of the protein solution required as medicine such as antibody drug, and whether the protein solution is suitable as medicine or not is determined. When the concentration required as medicine is equal to or higher than the threshold, for example, it is judged that the protein solution is not suitable as medicine. When the protein solution is not suitable as medicine, analysis can be repeated by changing a condition of the protein solution. 111-. (canceled)12. An analysis method for analyzing a protein solution utilizing Raman spectroscopy , comprising the steps of:acquiring a Raman spectrum of each of protein solutions, which contain a specific protein dissolved therein and have a plurality of concentrations, by Raman spectroscopy;calculating an index, which increases and decreases according to interaction between protein molecules in the protein solution, based on one or a plurality of predetermined peaks included in the Raman spectrum for each concentration;specifying a concentration range, in which a variation of the index against increase in concentration falls in a predetermined range, based on the index calculated regarding each concentration;specifying a threshold of concentration, which is to be used as a criterion for determining whether the specific protein is denatured or not, based on the concentration range; andcomparing the threshold with a specific concentration value set for the specific protein.13. An analysis method for analyzing a protein solution utilizing Raman spectroscopy , comprising the steps of:acquiring a Raman spectrum of ...

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Номер записи: 71
09-02-2017 дата публикации

MEDICAL RESEARCH TOOL COMPOSITION

Номер: US20170035912A1
Автор: VITALIANO FRANCO, VITALIANO GORDANA DRAGAN
Принадлежит:

The invention in suitable embodiments is directed to using purified, non-cage clathrin protein for purposes of assisting in drug discovery and development. In one aspect, a tool composition, formed in whole or in part from isolated, synthetic and or recombinant amino acid residues comprising in whole or in part one or more protein sequence, forms one or more type of tool for carrying out various elements and activities of drug discovery and development. 1. A medical research tool composition for use in discovering drugs comprising: a man made non-cage clathrin protein and has an amino acid sequence of at least 50 , 60 , 70 , 80 , or 90% sequence identity when compared to SEQ ID NO: 1 , SEQ ID NO: 2 , SEQ ID NO: 3 , SEQ ID NO: 4 , SEQ ID NO: 5 , SEQ ID NO: 6 , SEQ ID NO: 7 SEQ ID NO: 8 , SEQ ID NO: 9 , SEQ ID NO: 10 or SEQ ID NO: 11 , and including at least one of a medical research element of one or more type , wherein a formulation comprised of the preceding protein or composition and at least a portion of the medical research element is used to perform discovery of at least one medicinal aspect of a drug or use thereof , and administering the formulation in vitro or in vivo to one or more type of medical research subject.2. The medical research tool composition of further comprising , a man made protein that has at least 50 , 60 , 70 , 80 , or 90% sequence identity when compared to SEQ ID NO: 12 or SEQ ID NO: 13 , and the preceding protein disposed adjacent to the sequence according to , and binding to the sequence.3. The medical research tool composition of claim 1 , wherein the element is a small or large molecule element.4. The medical research tool composition of claim 1 , wherein the element is a biological element.5. The medical research tool composition of claim 1 , wherein the element is a chemical element.6. The medical research tool composition of claim 1 , wherein the element is bound together with the composition.7. The medical research tool ...

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Номер записи: 72
24-02-2022 дата публикации

MEASURING DEVICE FOR MEASURING AN INTENSIVE MEASURAND

Номер: US20220054018A1
Автор: HOSS Michael, WIORA Georg
Принадлежит: Courage + Khazaka Electronic GmbH

In a measuring device for measuring an intensive measurand, including at least one measuring chamber having at least one opening, the opening being placeable on the body to be examined. At least three sensors for measuring the intensive measurand are arranged in the measuring chamber, the sensors being arranged at different distances from the body to be examined during measurement. An evaluation device being provided which receives the values measured by the sensors and determines a total value for the intensive measured variable from the at least three measured values as well as a substance or energy diffusion rate. 127-. (canceled)28. A measuring device for measuring an intensive measurand , in particular the concentration of a substance emitted by a body by diffusion or the temperature , comprising at least one measuring chamber having at least one opening , the opening being placeable on the body to be examined ,wherein at least three sensors for measuring the intensive measurand are arranged in the measuring chamber, the sensors being arranged at different distances from the body to be examined during measurement,wherein an evaluating device is provided that receives the values measured by the sensors and determines a total value for the intensive measurand from the at least three measured values.29. The measuring device according to claim 28 , wherein the measuring chamber comprises at least two openings.30. The measuring device according to claim 28 , wherein a calculation rule is stored in the evaluating device claim 28 , on the basis of which the evaluating device determines the total value.31. The measuring device according to claim 30 , wherein the calculation rule stored in the evaluating device weights the values measured by the sensors differently to determine the total value for the intensive measurand.32. The measuring device according to claim 30 , wherein the calculation rule stored in the evaluating device uses a robust estimator when determining ...

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Номер записи: 73
09-02-2017 дата публикации

MEASUREMENT TECHNIQUES FOR LIQUID CRYSTAL PARAMETERS AND ION IMPURITIES

Номер: US20170038614A1
Автор: JI LIANHUA, ZOU HENRY ZHONG
Принадлежит:

Provided is a set of techniques for measuring different properties or parameters of liquid crystal mixtures by applying a driving waveform and measuring the response current and/or the optical response. This may be done by using specific liquid crystal test cells. Also provided are the optimized test cell parameters that are used in the algorithms for calculating the properties. 1. A method for measuring the twist elastic constant (K) of a liquid crystal mixture under test , the method comprising:providing a liquid crystal test cell having a pair of electrodes;placing the liquid crystal mixture under test into the liquid crystal test cell;applying an electrical driving signal to the electrodes of the liquid crystal test cell;measuring an electrical response signal from the electrodes; and{'sub': '22', 'based on the electrical driving signal and the electrical response signal, and in the absence of measuring light transmitted through or reflected off of the liquid crystal test cell, determining the twist elastic constant (K) for the liquid crystal mixture under test.'}2. A method as defined in claim 1 , wherein the determining includes determining dielectric properties of the liquid crystal test cell.3. A method as defined in claim 1 , wherein the determining includes determining a constant related to a geometry of the liquid crystal test cell.4. A method as defined in claim 1 , wherein the determining includes using the following equation: K=(V)(aπ)(∈|Δ∈|) claim 1 , where Vis the threshold minimum voltage that causes liquid crystal molecules to turn claim 1 , a is a feature factor that is a function of the test cell geometry claim 1 , ∈is the vacuum permittivity claim 1 , and |Δ∈| is the dielectric anisotropy.5. A method for measuring the twist elastic constant (K) of a liquid crystal mixture under test claim 1 , the method comprising:providing a liquid crystal test cell having a pair of electrodes;providing a light source that directs light into one side of the ...

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Номер записи: 74
24-02-2022 дата публикации

WATER ABSORBENT RESIN PARTICLES, ABSORBENT, ABSORBENT ARTICLE AND LIQUID SUCTION POWER MEASUREMENT METHOD

Номер: US20220055014A1
Автор: NISHIDA Moe
Принадлежит:

Disclosed is water-absorbent resin particles, in which a value of non-pressurization DW after 3 minutes is 14 ml/g or more, and a value of liquid suction power after 3 minutes measured by the following method is 11 ml/g or more. A liquid suction power measurement method: 0.3 g of the water-absorbent resin particles is uniformly dispersed in a cylindrical container having a mesh-like bottom and having an inner diameter of 26 mm; the cylindrical container is placed in a container containing 40 g of a physiological saline solution, the water-absorbent resin particles are caused to absorb the physiological saline solution for 30 minutes from the bottom of the cylindrical container, and thereby a swollen gel is obtained; and non-pressurization DW, which is measured in a state where another 0.3 g of the water-absorbent resin particles is uniformly dispersed on the swollen gel in the cylindrical container, is defined as liquid suction power. 1. Water-absorbent resin particles ,wherein a value of non-pressurization DW after 3 minutes is 14 ml/g or more, and a value of liquid suction power after 3 minutes measured by the following method is 11 ml/g or more,a liquid suction power measurement method: 0.3 g of the water-absorbent resin particles is uniformly dispersed in a cylindrical container having a mesh-like bottom and having an inner diameter of 26 mm; the cylindrical container is placed in a container containing 40 g of a physiological saline solution, the water-absorbent resin particles are caused to absorb the physiological saline solution for 30 minutes from the bottom of the cylindrical container, and thereby a swollen gel is obtained; and non-pressurization DW, which is measured in a state where another 0.3 g of the water-absorbent resin particles is uniformly dispersed on the swollen gel in the cylindrical container, is defined as liquid suction power.2. The water-absorbent resin particles according to claim 1 , wherein a content of silica particles is 1.8% by mass ...

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Номер записи: 75
24-02-2022 дата публикации

Diffusion Cell Clamping and Assembly Tools

Номер: US20220057313A1
Автор: Huang Joseph Zhili, Wen Ping
Принадлежит:

A diffusion/permeation cell, commonly referred to as a Franz cell, is provided for topical or transdermal drug delivery research and development in the pharmaceutical industry. The cell comprises a receptor container, a donor chamber, a quick clamping apparatus, and/or an assembly tool. Systems and methods provide a cost-effective diffusion cell, especially for use with an automatic diffusion release testing system. 2. The diffusion cell of claim 1 , wherein the clamping nut has a U-shape bottom plate and the threads on its upper body.3. The clamping nut of claim 1 , wherein the preferred material for the clamping nut is plastics and made by 3D printing or injection model fabrication.4. The clamping nut of claim 1 , wherein the donor cap is made from inert material comprising at least one of glass and teflon.5. The diffusion cell of claim 1 , wherein the pressing screw has an opening at its center and the threads on its body claim 1 , wherein a preferred material is plastics and made by 3D printing or injection model fabrication.6. A diffusion cell assembly tool claim 1 , comprising:a body;its top surface;a recess;raised pallets; andbaffle plates.7. The diffusion cell assembly tool of claim 6 , wherein the top surface has a contour profile of the U-shape bottom plate of the clamping nut.8. The diffusion cell assembly tool of claim 6 , wherein the recess has a contour profile of the receptor container of the diffusion cell.9. The diffusion cell assembly tool of claim 6 , wherein a height of the raised pallets is equal to a height of the U-shape bottom plate of the clamping nut.10. The diffusion cell assembly tool of claim 6 , wherein the baffle plates are higher than the thickness of the annular flange of the receptor container.11. The diffusion cell assembly tool of claim 6 , wherein the body of the tool is made from 3D printing or plastic injection model.12. A method of assembling a diffusion cell claim 6 , comprising:placing a donor plate with a center opening ...

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Номер записи: 76
24-02-2022 дата публикации

ANALYTICAL METHOD FOR DETERMINATION OF IN VITRO DRUG RELEASE PROFILE FROM MICRONEEDLE PATCHES

Номер: US20220057377A1
Автор: Ameri Mahmoud, He Aihua, Lewis Hayley
Принадлежит:

The present disclosure relates to a novel in vitro dissolution method to assess the release of a bioactive agent from an intracutaneous microneedle system wherein the bioactive agent is coated on or integral to the microneedles. The present disclosure further relates to a novel sample holder clip assembly specially adapted for use with microneedle arrays and patches. 1. A method for determining the in vitro dissolution profile of a bioactive agent from a microneedle patch , comprising the steps of:a. providing a microneedle patch comprising a bioactive agent;b. affixing the patch to an outer surface of a sample holder wherein the microneedles are oriented outward from the outer surface;c. applying a membrane over the microneedles and the patch;d. immersing the sample holder having the patch and membrane in a dissolution medium;e. taking at least 2 samples of the dissolution medium at different time points;f. determining the concentration of the bioactive agent in the samples; andg. calculating the rate of dissolution of the bioactive agent from the patch.2. The method of further comprising attaching a clip over the membrane and sample holder.3. The method of wherein the clip has an opening.4. The method of wherein the opening is a shape selected from the group consisting of rectangular claim 3 , square claim 3 , oblong claim 3 , circular claim 3 , parallelogram claim 3 , pentagon claim 3 , octagon claim 3 , hexagon claim 3 , rhombus claim 3 , oval claim 3 , and triangular.5. The method of wherein the opening is a size of about 10 cm claim 3 , or 9 cm claim 3 , or 8 cm claim 3 , or 7 cm claim 3 , or 6 cm claim 3 , or 5 cm claim 3 , or 4 cm claim 3 , or 3 cm claim 3 , or 2 cm claim 3 , or 1 cm.6. The method of wherein the dissolution medium has a volume of about 50 mL to about 200 mL.7. The method of wherein the dissolution medium has a volume of about 900 mL.8. The method of wherein the dissolution medium has a temperature of about 32 degrees.9. The method of wherein ...

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Номер записи: 77
12-02-2015 дата публикации

SYSTEMS AND METHODS FOR A SAMPLE FLUID COLLECTION DEVICE

Номер: US20150045694A1
Автор: Sullivan Benjamin, Zmina Steve
Принадлежит:

A fluid collection device comprising a body comprising a capsule interface, and a capsule configured to interface with the body via the capsule interface and configured to hold a sample receiving chip. The sample receiving chip comprises a substrate that receives an aliquot volume of a sample fluid, wherein the substrate is operatively shaped to receive the aliquot volume of sample fluid through capillary action, and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region, whereupon energy properties of the sample fluid can be transduced to produce a sample fluid reading. 124-. (canceled)25. A tear fluid collection device configured to collect an aliquot volume of less than 20 uL of tear fluid from a subject , comprisinga) a body; i. a tip portion that extends beyond the body sufficiently to allow the TCI card to receive the aliquot volume;', 'ii. a substrate configured to receive the aliquot volume and having a sample region which transfers energy to the aliquot volume and is sized such that the aliquot volume operatively covers a portion of the sample region; and, 'b) a tear collection interface (TCI) card configured to attach to the body and receive the aliquot volume, comprisingc) a removable sheath configured to attach to the TCI card.26. The collection device of claim 25 , wherein the collection device is configured to collect the aliquot volume from an inferior tear meniscus of the subject.27. The fluid collection device of claim 25 , wherein the TCI card comprises a vent hole.28. The collection device of claim 25 , wherein the tip portion of the TCI card has a width and shape sufficient to soften contact of the tip portion with an eye.29. The collection device of claim 25 , wherein the tip portion of the TCI card extends approximately 0.5 millimeters beyond the body.30. The collection device of claim 25 , wherein the sample region includes a plurality of electrodes ...

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Номер записи: 78
18-02-2016 дата публикации

CRYSTALS OF LAQUINIMOD SODIUM AND IMPROVED PROCESS FOR THE MANUFACTURE THEREOF

Номер: US20160046582A1
Автор: Frenkel Anton, Fristedt Ulf Tomas, Ioffe Vladimir, Jansson Karl-Erik, Laxer Avital
Принадлежит: TEVA PHARMACEUTICAL INDUSTRIES LTD.

The subject invention provides a mixture of Crystalline Laquinimod sodium particles, wherein (i) ≧90% of the total amount by volume of the laquinimod sodium particles have a size of ≦40 μm or (ii) ≧50% of the total amount by volume of the laquinimod sodium particles have a size of ≦15 μm and wherein: a) the mixture has a bulk density of 0.2-0.4 g/mL; b) the mixture has a tapped density of 0.40-0.7 g/mL; c) an amount of heavy metal in the mixture is no more than 20 ppm relative to the amount by weight of laquinimod sodium; d) an amount of MCQ in the mixture is no more than 0.15% relative to the amount of laquinimod sodium as measured by HPLC; e) an amount of MCQCA in the mixture is no more than 0.15% relative to the amount of laquinimod sodium as measured by HPLC; or f) an amount of MCQME in the mixture is no more than 0.12% relative to the amount of laquinimod sodium as measured by HPLC. The subject invention also provides a pharmaceutical composition comprising an amount of laquinimod and at least one of BH-3-HKAQ, MCQ, MCQCA, MCQME, NEA, and MCQEE. The subject invention also provides processes for preparing BH-3-HLAQ, MCQ, MCQCA, MCQEE, and compounds prepared by said processes. Further provided is a process for testing whether a sample of laquinimod contains an undesirable impurity. Further provided is a process for preparing a validated pharmaceutical composition comprising laquinimod, for preparing a pharmaceutical composition comprising laquinimod, or for distributing a validated batch of a pharmaceutical composition comprising laquinimod, for validating a batch of a pharmaceutical product containing laquinimod and a pharmaceutically acceptable carrier for distribution, and for preparing a packaged pharmaceutical composition comprising laquinimod, each comprising determining the amount of at least one of BH-3-HLAO, MCQ, MCQCA, MCQME Подробнее

Номер записи: 79
06-02-2020 дата публикации

Phase wetting detection and water layer thickness characterization in multiphase oil-water and oil-water-gas flow

Номер: US20200041397A1
Автор: Luciano Daniel Paolinelli
Принадлежит: OHIO UNIVERSITY

In one embodiment, a method of monitoring fluid flow includes mounting at least one probe including at least two electrodes to a conduit having a mixture including at least oil and water flowing therethrough and exciting the at least two electrodes with an AC voltage and a predetermined frequency. The method also includes measuring an impedance between the at least two electrodes and detecting a water layer based on the measured impedance. The mixture may also include gas. In another embodiment, a method of detecting phase wetting in a pipe includes measuring a high frequency impedance response of a two concentric electrode probe flush mounted in the pipe.

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Номер записи: 80
15-02-2018 дата публикации

APPARATUS AND METHODS FOR DETERMINING SURFACE WETTING OF MATERIAL UNDER SUBTERRANEAN WELLBORE CONDITIONS

Номер: US20180045633A1
Автор: Bardapurkar Sameer, Gajji Bhargav, Palla Venkata Gopala Rao, PINDIPROLU Sairam KS
Принадлежит:

Methods and apparatuses for determining surface wetting of metallic materials at downhole wellbore condition with fixed or changing well fluids are disclosed. In general, the methods according to the disclosure include carrying out an electrical impedance spectroscopy (“EIS”) for a system simulating downhole conditions for the wetting of a surface by simultaneously dynamically moving electrodes exposed to the well fluid while measuring the changes in electrical characteristics between the electrodes. 1. A method comprising the steps of:a. providing a first and second electrodes each having a surface thereon;b. wetting the surfaces on the first and second electrodes with a first fluid;c. immersing the surfaces on the first and second electrodes in a second fluid;d. moving the first and second electrodes in the second fluid; ande. at least once during or after applying the moving step, making an electrical impedance spectroscopy measurement between the first and second electrodes while maintaining the electrodes electrically insulated from each other and immersed in the second fluid.2. The method according to claim 1 , wherein the moving step creates shear between the surfaces and the second fluid.3. The method according to claim 1 , wherein the providing claim 1 , wetting claim 1 , immersing claim 1 , moving a measurement steps are performed at one or more of temperatures elevated above atmospheric temperature and pressures elevated above atmospheric pressure.4. The method according to claim 1 , wherein the moving step comprises rotating the first and second electrodes in the second fluid.5. The method according to claim 1 , additionally comprising the steps of: before the moving step claim 1 , making a first electrical impedance spectroscopy measurement between the first and second electrode; during or after the moving step claim 1 , making a second electrical impedance spectroscopy measurement between the first and second electrode; comparing the first electrical ...

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Номер записи: 81
15-02-2018 дата публикации

Automated Filter Changer

Номер: US20180045702A1
Автор: Downes Gary Charles, Shaw Steven William
Принадлежит:

An automatic filter changer that automatically inserts and removes a filter from a fluidic path. Filters are introduced into the automatic filter changer in stacks. The lead filter and each stack is removed from its respective stack one by one by a filter separator. The separated filters are deposited onto a shuttle plate which moves the filters into their respective fluidic paths. Fluid couplers connect to each filter to complete their respective fluidic paths and allow fluids to be filtered before sampling. Once collection of the samples is complete, the filters are removed from the fluidic path and discarded or saved for reuse. The shuttle path is returned to its original position to receive new filters to repeat the process again. A graphic user interface is provided to allow the user to program a specific set of instructions to automate the entire process. 1. An automatic filter changer , comprising:a. housing;b. a filter stack block attached to the housing, the filter stack block comprising a plurality of holes linearly arranged to receive a plurality of filter stacks, wherein each hole is configured to receive one filter stack;c. a filter separator positioned below the filter stack block, the filter separator configured to separate one filter at a time from each filter stack away from its respective filter stack sequentially so that a first filter from a first filter stack is separated before a first filter of a second filter stack;d. a shuttle plate positioned below the filter separator to catch a released filter, wherein a motor is operatively connected to the shuttle plate to move the shuttle plate in a horizontal direction to carry a set of released filters to a fluid coupler; ande. a centering plate assembly positioned to trap the released filter against the shuttle plate in alignment with the fluid coupler,f. wherein the shuttle plate comprises a plurality of slots defined by slot arm pairs, and the fluid coupler comprises a plurality of upper fluid ...

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Номер записи: 82
25-02-2016 дата публикации

APPARATUS FOR MEASURING RHEOLOGICAL PARAMETERS AND METHODS FOR ITS OPERATION

Номер: US20160054213A1
Автор: KHALDE Chirag, SANGWAI Jitendra
Принадлежит:

An apparatus for measuring rheological parameters of a multi-phase fluid is provided. The apparatus includes a static chamber containing a multi-phase fluid having at least a first phase and a second phase. The apparatus also includes a rotor member submersed in the multiphase fluid in the static chamber. The rotor member includes a first set of threads formed on a first portion of the rotor member submersed in the first phase of the multi-phase fluid and a second set of threads formed on a second portion of the rotor member submersed in the second phase of the multi-phase fluid. 1. An apparatus for measuring rheological parameters of a multi-phase fluid , the apparatus comprising:a static chamber containing a multi-phase fluid having at least a first phase and a second phase; anda rotor member submersed in the multi-phase fluid in the static chamber and rotatable about a rotational axis within the static chamber, wherein the rotor member comprises a first set of threads formed on a first portion of the rotor member submersed in the first phase of the multi-phase fluid and a second set of threads formed on a second portion of the rotor member submersed in the second phase of the multi-phase fluid.2. The apparatus of claim 1 , wherein the static chamber and the rotor member are coaxial.3. The apparatus of claim 1 , wherein the static chamber is formed of stainless steel claim 1 , hastelloy claim 1 , or combinations thereof.4. The apparatus of claim 1 , wherein the rotor member is formed of stainless steel claim 1 , hastelloy claim 1 , or combinations thereof.5. The apparatus of claim 1 , wherein the first set of threads and the second set of threads are oppositely angled.6. The apparatus of claim 5 , wherein a thread angle of the first set of threads is about 5 degrees to about 70 degrees.7. The apparatus of claim 5 , wherein a thread angle of the second set of threads is between 5 degrees and 70 degrees.8. The apparatus of claim 1 , wherein at least one of the first ...

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Номер записи: 83
25-02-2016 дата публикации

Method for establishing shenqi fuzheng injection fingerprint spectrum

Номер: US20160054276A1
Автор: Donglai LIU, Wenhua Huang, Xuehua Liu, Yangang SONG
Принадлежит: Limin Pharmaceutical Factory of Livzon Pharmaceutical Group

A method for establishing a Shenqi Fuzheng injection fingerprint spectrum, comprising: employing an ultra-high voltage liquid chromatography mass spectrometer to test the Shenqi Fuzheng injection, the chromatography conditions including: chromatographic column: Agilent Zorbax Eclipse Plus C18, 2.1 mm×100 mm, 1.8 μm; mobile phase: mobile phase A is 0.1% formic acid aqueous solution, and mobile phase B is 0.1% formic acid acetonitrile solution; employing gradient elution procedure as follows: 0-0.5 min, 95% of mobile phase A, and 5% of mobile phase B; 0.5-10 min, 95%-75% of mobile phase A, and 5%-25% of mobile phase B; 10-15 min, 75%-45% of mobile phase A, and 25%-55% of mobile phase B; 15-18 min, 45%-0% of mobile phase A, and 55%-100% of mobile phase B; and 18-20 min, 0% of mobile phase A, and 100% of mobile phase B.

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Номер записи: 84
25-02-2021 дата публикации

DETECTION METHOD FOR QUALITY GRADE OF TRADITIONAL CHINESE MEDICINE

Номер: US20210055276A1
Автор: CHANG Aibing, JIANG Dahai, Li XiaoHong, LIU Yanru, SONG Zhongxing, TANG ZHISHU, YANG Ningjuan
Принадлежит:

Disclosed is a detection method for quality grade of traditional Chinese medicine (TCM), including: detecting the levels of quality control index components of TCM and efficacy-related in vitro activity by establishing a correlation between principal components of TCM and in vitro activity; determining the state of sample cluster by principal component analysis; constructing a logistic regression model of quality grade versus index components and bioactivity and establishing corresponding grade detection formulas of Chinese medicinal materials by fitting a large number of sample data for Chinese medicinal materials from different places of origin and batches. The method of the present invention realizes the mathematical expression of a standard for quality difference of TCM, and provides a feasible solution for the industrialized evaluation of quality grades of Chinese medicinal materials or herbal slices finally. 1. A detection method for quality grade of traditional Chinese medicine (TCM) , wherein: the TCM may be Chinese medicinal materials or herbal slices; the detection method is established by constructing a model of correlation between bioactivity and component of TCM.2. The detection method for quality grade of TCM according to claim 1 , wherein the detection method comprises the following steps: (1) TCM test sample preparation and determination of component assay; (2) bioactivity assay for TCM; (3) principal component assay for TCM; and (4) establishment of TCM quality grade detection formulas by a logistic regression model.3. The detection method for quality grade of TCM according to claim 2 , wherein step (1) is specifically as follows:sample preparation: weighing approximately 0.3 g of Chinese medicinal materials or herbal slices accurately in a conical flask with cover, accurately adding 50 mL of methanol thereto, sealing tightly, weighing, sonicating for 30 min, cooling, weighing again, making up for a weight loss with methanol, shaking well, filtering ...

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Номер записи: 85
25-02-2021 дата публикации

QUANTITATION OF TAMOXIFEN AND METABOLITES THEREOF BY MASS SPECTROMETRY

Номер: US20210055277A1
Автор: Clarke Nigel
Принадлежит:

Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of norendoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and tamoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, norendoxifen, and other tamoxifen metabolites. 1. A method for determining an amount of tamoxifen and N-Desmethyl Tamoxifen in a human sample in a single mass spectrometry assay , comprising:(a) purifying the sample by liquid chromatography;(b) ionizing said tamoxifen and N-Desmethyl Tamoxifen to produce one or more ions detectable by mass spectrometry; and(c) detecting an amount of the ion(s) from step (b) by mass spectrometry; wherein the amount of the ion(s) detected is related to the amount of each of tamoxifen and N-Desmethyl Tamoxifen in said sample,wherein the method has a limit of quantitation of less than or equal to 1.5 ng/mL for tamoxifen and N-Desmethyl Tamoxifen.2. The method of claim 1 , further comprising protein precipitation prior to step (a).3. The method of claim 1 , further comprising filtration prior to step (a).4. The method of claim 1 , wherein said liquid chromatography is high pressure liquid chromatography (HPLC).5. The method of claim 1 , wherein said liquid chromatography is high turbulence liquid chromatography (HTLC).6. The method of claim 1 , further comprising detecting the amount of an internal standard.7. The method of claim 1 , wherein said ionization is in positive ion mode.8. The method of claim 1 , wherein said sample is a serum or plasma sample.9. The method of claim 1 , wherein said mass spectrometry is tandem mass spectrometry.10. The method of claim 1 , wherein further comprising determining an amount of metabolites selected from the group ...

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Номер записи: 86
23-02-2017 дата публикации

METHOD OF AND APPARATUS FOR FORMULATING MULTICOMPONENT DRUG

Номер: US20170052157A1
Автор: MORI Yoshikazu, NODA Keiichi
Принадлежит:

Provided are a method of and an apparatus for formulating a multicomponent drug capable of surely making a multicomponent drug meeting criteria for productization with high accuracy into a product. The method and apparatus obtain a chromatogram from an extract or a base of a multicomponent drug, evaluate whether the base meets the criteria for productization based on the obtained chromatogram with high accuracy, and subject the base determined in the high-accuracy evaluating as an accepted one meeting the criteria to dosage form processing, to produce a formulated drug having a given dosage-form. 1. A method of formulating a multicomponent drug , comprising:obtaining a chromatogram from a base of a multicomponent drug;evaluating whether the base meets criteria for productization based on the obtained chromatogram; andsubjecting the base determined in the evaluating of the base as an accepted one meeting the criteria for productization to dosage form processing, to produce a formulated drug having a given dosage-form, wherein gathering as a first target fingerprint peaks in which each one peak has a height that is a maximum value or an area value in signal strength and retention time points of the peaks detected from the chromatogram;', 'comparing the peaks of the first target fingerprint and peaks of a reference fingerprint as evaluation criteria corresponding to the first target fingerprint, to specify corresponding peaks between the first target fingerprint and the reference fingerprint;', 'obtaining target fingerprint peak feature values in which assigned peaks of the first target fingerprint which are specified and assigned to corresponding peaks of the reference fingerprint are quantified as feature values by comparing and evaluating the assigned peaks of the first target fingerprint and peaks of a plurality of reference fingerprints as evaluation criteria;', 'gathering as a second target fingerprint remaining peaks with the exclusion of the assigned peaks that ...

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Номер записи: 87
26-02-2015 дата публикации

Methods for Analyzing Cysteamine Compositions

Номер: US20150056712A1
Автор: Muttavarapu Ramesh, Powell Kathlene
Принадлежит:

Methods of analyzing purity of compositions comprising cysteamine and detecting impurities in cysteamine compositions are described. 1. A method of analyzing purity of a composition comprising cysteamine comprising:(i) injecting a sample solution comprising cysteamine onto a reverse-phase HPLC column;(ii) eluting the sample from the column using a mobile phase comprising an alkyl sulfonic acid, a buffer, acetonitrile, and methanol; and(iii) measuring the eluted sample using a UV detector at a wavelength of about 170 nm to about 250 nm.2. The method of claim 1 , further comprising dissolving a cysteamine sample in a solvent having an acidic pH to form the sample solution comprising cysteamine.3. A method of analyzing purity of enteric-coated cysteamine beads comprising:(i) grinding enteric-coated cysteamine beads;(ii) dissolving the ground beads in a solvent having an acidic pH to form a sample solution comprising cysteamine;(iii) injecting the sample solution onto a reverse-phase HPLC column;(iv) eluting the sample from the column using a mobile phase comprising an alkyl sulfonic acid, a buffer, acetonitrile, and methanol; and(v) measuring the eluted sample using a UV detector at a wavelength of about 170 nm to about 250 nm.400. The method of claim or claim 1 , wherein the solvent comprises an alkyl sulfonic acid claim 1 , a buffer claim 1 , acetonitrile claim 1 , and methanol.5. (canceled)6. The method of or claim 1 , wherein the HPLC column has a packing material particle size of about 1 μm to about 10 μm in diameter.7. (canceled)8. The method of or claim 1 , wherein the HPLC column has an internal diameter of about 0.1 mm to about 10 mm.911-. (canceled)12. The method of or claim 1 , wherein the eluted sample is measured using a UV detector at a wavelength of about 180 nm to about 230 nm.13. (canceled)14. The method of or claim 1 , wherein the mobile phase comprises:about 5% to about 95% by volume of an aqueous solution having a pH of about 2.0 to 3.0, the aqueous ...

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Номер записи: 88
05-03-2015 дата публикации

Method of cavitation/flashing detection in or near a process control valve

Номер: US20150059886A1
Автор: Shawn W. Anderson
Принадлежит: FISHER CONTROLS INTERNATIONAL LLC

A system and apparatus for detecting and monitoring cavitation inside a flow control device, such as a control valve, includes an acoustic emission sensor coupled to the flow control device in a manner to acquire acoustic signals caused by cavitation. A processor receives acoustic information from the acoustic emission sensor. The processor selectively identifies cavitation events from the acoustic information that meet certain predefined criteria. Cavitation levels are monitored based on at least one of a rate of cavitation events and intensity of individual cavitation events. The cavitation levels may be used to identify the presence of cavitation in the flow control device, to track accumulated cavitation in the flow control device, and/or to identify significant changes in the cavitation levels over time. This information may be used to reduce cavitation, estimate repair and maintenance, and/or monitor performance of the flow control device.

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Номер записи: 89
05-03-2015 дата публикации

AUTHENTICATION SYSTEMS EMPLOYING FLUORESCENT DIAMOND PARTICLES

Номер: US20150060699A1
Автор: Janoff Andrew S.
Принадлежит:

Authentication systems for products employing populations containing particles of diamonds that have fluorescent emissions of various wavelengths, intensities and durations are described. By varying the populations of diamond particles in products to be labeled, multiple different identification systems can be obtained permitting authentication taggants for large numbers of different products. 1. A product which comprises a prescribed form of an authentication system which system comprises at least one population of fluorescent diamond particles wherein the wavelength , duration and intensity of the fluorescence emission of said particles is dependent on the wavelength , duration and intensity of the excitation energy ,wherein said prescribed form consists of one homogeneous population of diamond particles, orwherein said prescribed form consists of one heterogeneous population of said particles; orwherein said prescribed form comprises at least two different homogeneous populations of fluorescent diamond particles; orwherein said prescribed form comprises at least one population that is homogeneous and at least one population that is heterogeneous; andwherein each different population has a unique fluorescence wavelength or intensity or duration or combination thereof.2. The product of which is associated with a code designating the excitation wavelength(s) and/or duration(s) and/or intensity(ies) that cause said population(s) to fluoresce claim 1 , and/or designates the wavelength(s) and/or duration(s) and/or intensity(ies) of the fluorescent emission of the prescribed form.3. The product of wherein said code is secret and disclosed only to designated recipient(s).4. The product of wherein the prescribed form of authentication system is distributed throughout the product.5. The product of which is a powder claim 1 , semisolid claim 1 , emulsion or liquid.6. The product of which is a solid.7. The product of wherein the solid has a surface and the prescribed form of ...

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Номер записи: 90
10-03-2022 дата публикации

GREASE EVALUATION

Номер: US20220074916A1
Автор: Khonsari Michael M., Koottaparambil Lijesh
Принадлежит:

Methods of evaluating viscous compositions are disclosed. The methods may be used to evaluate degradation levels of lubricants including grease. The methods may include preparing a surface for testing by leveling and flattening a viscous composition, placing a drop of a liquid on the flattened leveled surface, evaluating the observed contact angle between the drop and the surface, and then comparing the observed contact angle to a reference contact angle. 1. A method of evaluating lubricant comprising:a. acquiring a sample of a mechanically used grease from a mechanical device;{'claim-text': ['i. orienting a portion of the sample to level and', 'ii. flattening the portion of the sample;'], '#text': 'b. preparing a grease surface for testing by'}c. placing a drop of a liquid on the grease surface;d. evaluating an observed contact angle between the drop and the grease surface; ande. comparing the observed contact angle to a reference contact angle;f. wherein the mechanically used grease is degraded as compared to a pristine grease of the same type.2. The method of wherein the mechanically used grease has experienced bleed off as compared to the pristine grease of the same type.3. The method of wherein the mechanically used grease has experienced oxidation as compared to the pristine grease of the same type.4. The method of wherein the mechanically used grease has experienced mechanical degradation as compared to the pristine grease of the same type.5. The method of wherein the mechanically used grease has experienced contamination as compared to the pristine grease of the same type.6. The method of wherein the mechanically used grease has experienced water contamination as compared to the pristine grease of the same type.7. The method of wherein the observed contact angle correlates with the kinematic viscosity of the mechanically used grease across varying degradation levels for a degradation type wherein the degradation type is selected from bleed off claim 1 , ...

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Номер записи: 91
01-03-2018 дата публикации

Alkylaromatic Sulfonate Compositions From Mixed Hydrocarbons

Номер: US20180057451A1
Автор: BIELENBERG James R., Gooding Beatrice M., Owens Tracie L., Reiner Virginia M., Zhang Jingwen, ZHAO Mosha H.
Принадлежит:

Provided herein are various methods for forming alkylaromatic sulfonate compositions and blended alkylaromatic sulfonate compositions, and such compositions themselves. The methods of various embodiments include obtaining a C-Chydrocarbon mixture, optionally treating the mixture to concentrate the mixture in sulfonatable aromatics, and sulfonating the mixture to form the alkylaromatic sulfonates. The mixture or treated mixture may be blended with linear alkyl benzene (LAB) compositions and sulfonated, and/or the alkylaryl sulfonates may be blended with linear alkylbenzene sulfonate (LAS) compositions, to form the blended alkylaromatic sulfonates of some embodiments. These compositions and processes for making them may be tailored to serve a variety of end uses, such as detergents in cleaning solutions or for enhanced oil recovery operations, and/or as low foaming and/or hydrotropic additives in detergent formulations, and the like. 1. A process comprising:{'sub': 7', '30, 'claim-text': wherein the hydrocarbon mixture comprises 5-40 wt % sulfonatable aromatics comprising: (i) mono-alkyl benzenes; (ii) multi-alkyl benzenes in which any two adjacent alkyl substitutions on the benzene may be joined to form a non-aromatic ring fused to the benzene, provided that either or both of the benzene and the fused non-aromatic ring is further alkyl-substituted; and, optionally, (iii) alkyl-substituted polycyclic aromatics;', 'further wherein the hydrocarbon mixture comprises 1.75-30 wt % of the mono-alkyl benzenes, 0.25-30 wt % of the multi-alkyl benzenes, and 0-20 wt % of the alkyl-substituted polycyclic aromatics, such wt % s based on the total mass of the hydrocarbon mixture;, '(a) obtaining a hydrocarbon mixture comprising at least 90 wt % C-Chydrocarbons;'} wherein the treating comprises 1, 2, 3, 4, or 5 solvent extractions; and', 'further wherein the precursor alkylaromatic composition comprises 15-35 wt % mono-alkyl benzenes, 15-30 wt % multi-alkyl benzenes; and 0-25 wt % ...

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Номер записи: 92
01-03-2018 дата публикации

Alkylaromatic Sulfonate Compositions From Mixed Hydrocarbons

Номер: US20180057452A1
Автор: Jingwen Zhang, Mosha H. ZHAO, Tracie L. Owens, Virginia M. REINER
Принадлежит: ExxonMobil Chemical Patents Inc

Provided herein are various methods for forming alkylaromatic sulfonate compositions and blended alkylaromatic sulfonate compositions, and such compositions themselves. The methods of various embodiments include obtaining a C 8 -C 30 hydrocarbon mixture, optionally treating the mixture to concentrate the mixture in sulfonatable aromatics, and sulfonating the mixture to form the alkylaromatic sulfonates. The mixture or treated mixture may be blended with linear alkyl benzene (LAB) compositions and sulfonated, and/or the alkylaryl sulfonates may be blended with linear alkylbenzene sulfonate (LAS) compositions, to form the blended alkylaromatic sulfonates of some embodiments. These compositions and processes for making them may be tailored to serve a variety of end uses, such as detergents in cleaning solutions or for enhanced oil recovery operations, and/or as low foaming and/or hydrotropic additives in detergent formulations, and the like.

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Номер записи: 93
01-03-2018 дата публикации

Alkylaromatic Sulfonate Compositions From Mixed Hydrocarbons

Номер: US20180057453A1
Автор: Owens Tracie L., Reiner Virginia M., Zhang Jingwen, ZHAO Mosha H.
Принадлежит:

Provided herein are various methods for forming alkylaromatic sulfonate compositions and blended alkylaromatic sulfonate compositions, and such compositions themselves. The methods of various embodiments include obtaining a C-Chydrocarbon mixture, optionally treating the mixture to concentrate the mixture in sulfonatable aromatics, and sulfonating the mixture to form the alkylaromatic sulfonates. The mixture or treated mixture may be blended with linear alkyl benzene (LAB) compositions and sulfonated, and/or the alkylaryl sulfonates may be blended with linear alkylbenzene sulfonate (LAS) compositions, to form the blended alkylaromatic sulfonates of some embodiments. These compositions and processes for making them may be tailored to serve a variety of end uses, such as detergents in cleaning solutions or for enhanced oil recovery operations, and/or as low foaming and/or hydrotropic additives in detergent formulations, and the like. 3. The process of claim 1 , wherein the hydrocarbon mixture comprises at least 95 wt % of the alkylated naphthalenes claim 1 , and the blended alkylaromatic precursor comprises (i) from 2 to 60 wt % of the alkylated naphthalenes claim 1 , and (ii) from 40 to 98 wt % of the LAB composition.4. The process of claim 3 , wherein the blended alkylaromatic precursor comprises (i) from 2 to 25 wt % of the alkylated naphthalenes claim 3 , and (ii) from 75 to 98 wt % of the LAB composition.5. The process of claim 2 , wherein each of the alkylated naphthalenes is a tri-alkyl-substituted naphthalene claim 2 , such that one of R-Ris H.6. The process of claim 4 , wherein Ris H claim 4 , Ris C-Calkyl claim 4 , and Rand Rare each C-Calkyl.7. The process of claim 5 , wherein each of the alkylated naphthalenes is 6 claim 5 ,7-dimethyl-1-(4-methylpentyl)-Naphthalene.8. The process of claim 1 , wherein the hydrocarbon mixture comprises at least 95 wt % of the di-alkylbenzenes claim 1 , and the blended alkylaromatic precursor comprises (i) from 2 to 60 wt % ...

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Номер записи: 94
04-03-2021 дата публикации

MEASURING DEVICE AND METHOD OF PHYSICAL PROPERTY MEASURING

Номер: US20210060637A1
Автор: CHIANG Tsung-Hsuan, CHUANG Tsung-Han, CHUNG Chih-Ang, HO JENG-RONG, Jang Jason Shian-Ching, LEE Ya-Huan, YEN Chih-Shan
Принадлежит:

A measuring device includes a furnace, a draining vessel, a loader and a computing system for physical properties. The draining vessel with molten metal fluid is in the furnace. The loader accumulates the molten metal fluid from the draining vessel. The computing system includes a recording unit, transform unit, computing unit and processor. The recording unit records the vessel information. By the assumed physical parameters and the vessel information, the transform unit transforms a weight of the molten metal fluid in the loader into a first length criterion, and the computing unit simulates the flowing of the molten metal fluid to have a second length criterion. The processor minimizes the difference of the first and the second length criterion by changing the assumed physical parameters. The physical properties of the molten metal fluid are determined when the difference is minimized. 1. A measuring device for measuring physical properties of a molten metal fluid comprising:a furnace having a chamber;a draining vessel located in the chamber and having an opening, wherein the draining vessel is configured to accommodate the molten metal fluid;a loader aligned with the opening to accumulate the molten metal fluid from the draining vessel during a time period; and a recording unit recording a vessel information of the draining vessel;', 'a transform unit configured to transform a weight of the molten metal fluid accumulated in the loader during the time period into a first length criterion;', 'a computing unit configured to simulate flowing of the molten metal fluid to have a second length criterion by assumed physical parameters and the vessel information; and', 'a processor configured to minimize a difference function of the first and the second length criterions by changing the assumed physical parameters, wherein current physical parameters of the assumed physical parameters are determined as the physical properties of the molten metal fluid when the difference ...

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Номер записи: 95
01-03-2018 дата публикации

METHOD FOR PRODUCING POLYPEPTIDE HETERO-OLIGOMER

Номер: US20180057607A1
Автор: Hori Yuji, Igawa Tomoyuki, Kadono Shojiro, Katada Hitoshi
Принадлежит: Chugai Seiyaku Kabushiki Kaisha

It is intended to provide a method for efficiently and stably producing a heteromultimer by incubating homo variants of plural types of heavy chain constant region-containing polypeptides differing in antigen-binding activity under a reducing condition that reorganize the inter-polypeptide disulfide bond between cysteine residues outside of core hinge regions. A feature of the production method of the present invention is that amino acid residues in the core hinge regions do not form any disulfide bond. 1. A method for producing a heteromultimer , comprising the steps of:a) providing a homologous form of a first polypeptide having a first antigen-binding activity and comprising a heavy chain constant region;b) providing a homologous form of a second polypeptide having a second antigen-binding activity that is different from the first antigen-binding activity and comprising a heavy chain constant region;c) incubating the homologous form of the first polypeptide and the homologous form of the second polypeptide together under a reducing condition that allows cysteines outside of core hinge regions to cause disulfide bond isomerization; andd) obtaining a heteromultimer comprising the first and second polypeptides, wherein amino acid residues in the core hinge regions do not form any disulfide bond.2. The production method according to , wherein step a) of comprises the step of providing a third polypeptide that forms a multimer with the first polypeptide , and step b) comprises the step of providing a fourth polypeptide that forms a multimer with the second polypeptide.3. The production method according to claim 2 , wherein the third polypeptide and the fourth polypeptide are antibody light chains.4. The production method according to any one of to claim 2 , wherein the outside of core hinge regions are light chain constant regions.5. The production method according to claim 4 , wherein in the heavy chain constant region of the first and/or the second polypeptide claim ...

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Номер записи: 96
21-02-2019 дата публикации

Method for predictive determination of the behavior of a reactive mixture intended for obtaining a geopolymer, and method for optimization of said geopolymer

Номер: US20190056373A1
Автор: Alexandre Autef, Ameni Gharzouni, Elodie Prud'Homme, Emmanuel JOUSSEIN, Laëticia Vidal, Sylvie Rossignol
Принадлежит: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, UNIVERSITE DE LIMOGES

A method for determination of the behavior of a reactive mixture intended for obtaining a geopolymer. The reactive mixture comprises at least one aluminosilicate material. The method includes determining a proportion of amorphous phase of the at least one aluminosilicate material and determining a degree of wettability of the at least one aluminosilicate material. If the proportion of amorphous phase is greater than 45% and if the degree of wettability is situated in a range between 300 μg/l and 1400 μg/l, then the reactive mixture, formed by the reaction of the at least one aluminosilicate material with an alkaline solution, forms a geopolymer.

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Номер записи: 97
03-03-2016 дата публикации

DISSOLUTION TEST EQUIPMENT

Номер: US20160061801A1
Автор: Hughes Lyn, Wright Donald Frederick
Принадлежит:

Apparatus and method for dissolution testing of active substances in various dosage forms is provided. The apparatus has filtration cells equipped and configured to simulate bodily functions, operate continuously and facilitate testing various types of dosage forms including, but not limited to, tablets, capsules and those having non-disintegrating substrates. 1. A dissolution test method using an apparatus , the apparatus comprising wherein said shelf screen is a mesh screen compatible with said medium and having a have a mesh size of from 200 mesh to 10 mesh;', 'wherein said first chamber additionally comprises tubing configured to remove liquid and particle solids from below said shelf screen to said second chamber;', 'wherein said first chamber additionally comprises a lid, and said first chamber additionally comprises a hole in the lid for sample addition;, 'a) a first chamber comprising a base and a shelf screen and being capable of transferring solid particles to said second chamber;'}b) said second chamber connected in series to said first chamber via said tubing and being capable of retaining solids;c) at least one supply of media that can be continuously passed into one or more of said chambers;d) a medium analysis device that analyzes effluent from said chambers for substances of interest in the tests; wherein each of said chambers has a sample addition port and an agitator that mixes the sample and medium; and', 'wherein said agitator of said first chamber is proximate to said base and said shelf screen is positioned in said first chamber, above said agitator, on an opposite side of said agitator from said base,', 'the dissolution test method comprising the steps of:, 'e) a heating device that controls temperature of medium in each of said chambers;'}A) passing one or more media through at least said first and second chambers;B) adding the test sample to the first chamber;C) passing medium through each of said chambers such that any undissolved portion ...

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Номер записи: 98
01-03-2018 дата публикации

VISUALIZER, MEASUREMENT SYSTEM, AND MEASUREMENT METHOD

Номер: US20180058841A1
Автор: WAKITA Naohide
Принадлежит:

A state visualizer according to one aspect of the present disclosure includes an optical member including a fixed part that has a fixed relative positional relationship with an object to be measured and a movable part that is movably supported by the fixed part and keeps a constant angle with respect to a gravity direction, the optical member retroreflecting a light or an electromagnetic wave in a case where the fixed part and the movable part are in a predetermined positional relationship. The optical member changes an intensity of the light or the electromagnetic wave reflected in a retroreflection direction in accordance with a change of a relative positional relationship between the fixed part and the movable part. 1. A visualizer , comprising:an optical member including a fixed part that has a fixed relative positional relationship with an object to be measured and a movable part that is movably supported by the fixed part and keeps a constant angle with respect to a gravity direction, the optical member retroreflecting a light or an electromagnetic wave in a case where the fixed part and the movable part are in a predetermined positional relationship, whereinthe optical member changes an intensity of the light or the electromagnetic wave reflected in a retroreflection direction in accordance with a change of a relative positional relationship between the fixed part and the movable part.2. The visualizer according to claim 1 , whereinthe optical member includes a first mirror having a first mirror surface, a second mirror having a second mirror surface, and a third mirror having a third mirror surface, the first mirror surface, the second mirror surface, and the third mirror surface intersecting and facing one another;the first mirror is included in the fixed part,the second mirror is included in the movable part and is supported by the fixed part so that the second mirror surface keeps a constant angle with respect to the gravity direction; andthe optical ...

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Номер записи: 99
04-03-2021 дата публикации

METHOD FOR PRODUCING LIBRARY FOR USE IN PREDICTION OF ACTION OF SUBSTANCE OF INTEREST ON LIVING BODY, AND METHOD FOR EVALUATING ACTION OF SUBSTANCE OF INTEREST ON LIVING BODY BASED ON CHANGE IN ACTION PARAMETER OR THE LIKE OF ZEBRAFISH

Номер: US20210062367A1
Автор: KOIWA Junko, TANAKA Toshio, YAMANAKA Mikiko
Принадлежит:

A method for producing a library for use in prediction of the action of a substance of interest on a living organism, the library having a large number of numerical data obtained based on change in a behavioral parameter of zebrafish and a large number of numerical data representing change in expression levels of genes integrated and recorded therein. 1. A method for producing a library for use in prediction of the action of a substance of interest on the living organism , the library having a large number of numerical data obtained based on change in a behavioral parameter of zebrafish and a large number of numerical data representing change in expression levels of genes integrated and recorded therein , the method comprising:preparing a substance of known action that is a substance whose action on the living organism is known;measuring a behavioral parameter of zebrafish not given the substance of known action in a bath having the zebrafish therein;administering the substance of known action to the bath having the zebrafish therein and measuring the behavioral parameter of the zebrafish after the administration of the substance of known action in the bath having the zebrafish therein;detecting change in the behavioral parameter of the zebrafish by the administration of the substance of known action;subdividing data representing the change in the obtained behavioral parameter and converting the data into a large number of numerical data;normalizing the large number of numerical data obtained based on the change in the behavioral parameter;normalizing a large number of numerical data representing the change in expression levels of genes after the administration of the substance of known action; andintegrating and recording the large number of numerical data obtained based on the change in the behavioral parameter and the large number of numerical data representing change in expression levels of genes, both normalized.2. The method for producing a library according ...

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Номер записи: 100