11-04-2013 дата публикации
Номер: US20130090472A1
The invention provides compounds of the Formula (I), in which W is independently selected from W, W, W, W, W, or W represents a pair of substituents independently selected from H, alkyl, aryl or amide in which the amide is optionally part of a linking chain, and the Z—Zbonds (n=4-17; n′=n+1) are optionally of any whole or partial bond order, Y is Yor Y represents a pair of substituents independently selected from H, C--Calkyl, Zor Zaryl, or Y is optionally a bridging structure that may comprise one or more C--Camide, C--Cether, or C--Cester groups, R-Rare independently selected from no substituent, a lone pair of electrons, H, halogen, C-Caryl, C- C-alkyl, amine, C--Calkylamine, C--Camide, nitro, cyano, carboxyl, C--Cester, phosphane, thiol, C--Cthioether, OR′, and suitable pairs of adjacent R groups (R-R) may optionally together form part of a Cor Caryl ring, a Zor Zring, R′ is independently selected from H, C--Calkyl, Zor Zaryl, C--Cester, poly(—CO—), amine, and C--Calkylamine, Z-Zare independently selected from C, N, P, O, and S, and X is a pharmaceutically acceptable anion, for the treatment of cancer. 2. The compound of claim 1 , in which the anion is selected from halide claim 1 , hexafluorophosphate claim 1 , nitrate claim 1 , and triflate.3. The compound of claim 1 , in which Y represents two hydrogen atoms or Y.4. The compound of claim 3 , in which Y is Yand Zand Zare N.5. The compound of claim 4 , in which Z-Zare C.6. The compound of claim 1 , in which R-Rare selected from H claim 1 , C-Calkyl claim 1 , O—C-Calkyl claim 1 , hydroxyl and halogen.7. The compound of claim 6 , in which C-Calkyl is methyl claim 6 , O—C-Calkyl is O-ethyl claim 6 , and halogen is chlorine.8. The compound of claim 1 , in which W is selected from W claim 1 , W claim 1 , WWor W.9. The compound of claim 8 , in which R-Rare selected from H claim 8 , C-Calkyl claim 8 , O—C-Calkyl and halogen.10. The compound of claim 9 , in which C-Calkyl is methyl claim 9 , O—C-Calkyl is O-ethyl and ...
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