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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 8. Отображено 8.
07-07-2023 дата публикации

Synthesis method of topiroxostat

Номер: CN116396275A
Автор: QIN HUAWEI, ZHU QINGGUO, LIU BOWEI, ZHAO MIN, CAI YIFAN, ZHAO PU, ZHOU ZHIKUI
Принадлежит:

The invention discloses a synthesis method of topiroxostat, and belongs to the technical field of triazole heterocyclic compound synthesis. The preparation method is characterized by comprising the following steps: by taking 4-cyanopyridine as a raw material, oxidizing to generate 4-cyanopyridine nitrogen oxide, and then carrying out Pinner condensation reaction to generate 4-((2N-isonicotinoyl hydrazine) formamidine) pyridine nitrogen oxide; the preparation method comprises the following steps: taking 2-(2-cyanopyridine-4-yl) formamidino) isonicotinoyl hydrazine as a raw material, directly carrying out a cyanation reaction to obtain N '-((2-cyanopyridine-4-yl) formamidino) isonicotinoyl hydrazine, after the reaction is finished, directly carrying out a heating reaction, carrying out intermolecular cyclization to construct a triazole structure and generate topiroxostat, and refining to obtain a topiroxostat refined product. The synthesis method has the advantages of simple steps, convenient ...

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Номер записи: 1
04-07-2023 дата публикации

Directional synthesis method of process impurity R of mactentan

Номер: CN116375652A
Автор: ZHU QINGGUO, FENG SHIYU, QIN HUAWEI, CAI YIFAN, HU DEXING, LI YONGHUA, LIU MENGHUI, REN HONGWEI, ZHOU ZHIKUI
Принадлежит:

The invention provides a directional synthesis method of a process impurity R of mactentan, and belongs to the technical field of heterocyclic compounds. The preparation method comprises the following steps: preparing methanesulfonate R-1 from a macsutentan intermediate 1 and methanesulfonyl chloride, carrying out a condensation reaction on the methanesulfonate R-1 and activated macsutentan, and carrying out quenching, post-treatment, crystallization and column separation to obtain a process impurity R. According to the scheme, the process impurity R with relatively high purity can be directly obtained in an oriented manner, and quantitative monitoring of the specific impurity R in the production process of the mactentan is realized.

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Номер записи: 2
18-07-2023 дата публикации

Method for detecting specified elements in lanthanum carbonate

Номер: CN116448864A
Автор: SUO ZHEDAN, WANG XIA, ZHOU ZHIKUI, GUO JIANYING, QIAO XINHUI, JI CHAOWEI, WANG JIANFENG, LUO MIN, SU MENG
Принадлежит:

The invention provides a method for detecting specified elements in lanthanum carbonate, and belongs to the technical field of drug analysis and detection. A lanthanum solution is added into the linear control solution, the concentration of the lanthanum solution in the linear control solution is matched with the concentration of lanthanum in the sample solution, and the linear correlation coefficient R of a specified element in the sample solution is larger than 0.99; pumping a certain amount of lanthanum solution linear blank solution matched with the matrix solution in concentration into the instrument, and stabilizing the instrument matrix; and drawing a standard curve of the sample solution by adopting an internal standard method in a helium mode to complete detection of specified elements. When the method is used for measuring V, Co, Ni, As, Se, Cd, Hg and Pb in lanthanum carbonate, the detection limit is low, the recovery rate is good, and the stability of all solutions is good within ...

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Номер записи: 3
07-04-2023 дата публикации

Preparation method of fudosteine

Номер: CN115925593A
Автор: ZHU QINGGUO, QIU CAIYUN, ZHOU ZHIKUI, CAI YIFAN, YANG BINGBING, FENG SHIYU, DENG MINGZHI
Принадлежит:

The invention discloses a preparation method of fudosteine, which belongs to the technical field of medical synthesis, and is characterized by comprising the following steps: (1) 3-chloro-1-propanol treatment: extracting and washing 3-chloro-1-propanol with a non-polar solvent for 2-4 times, and removing an organic layer for later use; or dissolving 3-chloro-1-propanol in water, washing with a non-polar solvent for 2-4 times, and removing the organic layer to obtain a 3-chloro-1-propanol aqueous solution for later use; (2) carrying out fudosteine reaction: carrying out reaction on L-cysteine and the treated 3-chloro-1-propanol at the temperature of 30 to 60 DEG C; (3) crystallization and purification: dropwise adding an organic solvent into the concentrated solution obtained in the step (2) for crystallization, cooling, filtering and drying to obtain fudosteine; according to the method, the raw material 3-chloro-1-propanol generating impurities is pretreated, and then ethanol crystallization ...

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Номер записи: 4
23-06-2023 дата публикации

Method for detecting residual quantity of methyl sulfamate

Номер: CN116297937A
Автор: HU DEXING, LI QILING, QUAN WENRUI, ZHAO KAIHU, LIAN MIAOLI, ZHOU ZHIKUI, YAO LIGAO, QIU JIAJUN
Принадлежит:

The invention provides a method for detecting residual quantity of methyl sulfamate, and belongs to the technical field of testing and analyzing materials by utilizing column chromatography. The method comprises the following steps: respectively preparing a derivatization reagent, an internal standard solution, a reference substance solution and a test solution, adding the derivatization reagent into a sample to be detected, heating and deriving to promote a target object to be converted into a detection target object, and then forming a stationary phase by cyanopropyl benzene and dimethyl siloxane for gradient elution. The method is applied to quantitative determination of methyl sulfamate trace residues, the detection sensitivity can reach 0.7468 ng/ml, the method has the advantages of being simple, sensitive, accurate, reliable, high in stability, good in reproducibility and the like, and the recovery rate is 95.01%-108.56%.

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Номер записи: 5
25-04-2023 дата публикации

Method for determining residual quantity of L-tartaric acid in tetrahydroisoquinoline

Номер: CN116008432A
Автор: HU DEXING, WANG LIHONG, HE FENGJIE, LI KAIYING, ZHAO KAIHU, LIAN MIAOLI, ZHOU ZHIKUI, YAO LIGAO, QIU JIAJUN
Принадлежит:

The invention provides a method for determining the residual quantity of L-tartaric acid in tetrahydroisoquinoline, and belongs to the technical field of medicine analysis. A high performance liquid chromatography method is adopted, octadecylsilane chemically bonded silica is used as a filler of a chromatographic column for separation, a UV detector is used for quantitative analysis, and chromatographic conditions are as follows: a mobile phase is composed of a mobile phase A and a mobile phase B, the mobile phase A is a water phase with the pH value of 2.8-3.2 and accounts for 90-100% (V/V) of the total amount of the mobile phase, and the mobile phase B is a water phase with the pH value of 2.8-3.2 and accounts for 90-100% (V/V) of the total amount of the mobile phase. The mobile phase A is acetonitrile, the mobile phase B is acetonitrile, the mobile phase is subjected to gradient elution, and the flow velocity is 0.6-0.8 mL/min; the column temperature is 28-32 DEG C; the detection wavelength ...

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Номер записи: 6
16-11-2011 дата публикации

Chemical preparation method of norfloxacin

Номер: CN0102241629A
Автор: JIAJUN QIU, CONG LIU, LIGAO YAO, LIN JUN, LONG SHU, GUOYANG SHAN, ZHIKUI ZHOU, QIU JIAJUN, LIU CONG, YAO LIGAO, SHU LONG, SHAN GUOYANG, ZHOU ZHIKUI
Принадлежит:

The invention mainly discloses a chemical preparation method of norfloxacin. The chemical preparation method is performed by carrying out reaction on 1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (formula I) and piperazine (formula II) used as raw materials, Lewis acid used as a catalyst and alcohol used as a solvent at a certain temperature for a certain period of time, and then carrying out post-treatment to obtain norfloxacin. The chemical preparation method disclosed by the invention has the advantages of mild reaction conditions, high reaction selectivity, and extremely low ratio of a 6-fluoro-substituted isomer, and is a very competitive synthesis route.

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Номер записи: 7
23-06-2023 дата публикации

Quantitative detection method for genotoxic impurities in dihydrohomoerythromycin

Номер: CN116297979A
Автор: GUO JING, WANG XIA, ZHOU ZHIKUI, GUO JIANYING, SUO ZHEDAN, LUO MIN
Принадлежит:

The invention provides a quantitative detection method for genotoxic impurities in dihydrohomoerythromycin, and belongs to the technical field of saccharides and derivatives thereof. The method comprises the following steps: adding dichloromethane into dihydrohomoerythrocin, and carrying out ultrasonic treatment to obtain a test solution; and determining genotoxic impurities in the test solution, wherein the genotoxic impurities comprise methyl methanesulfonate and ethyl methanesulfonate. The scheme has the advantages of high detection sensitivity, qualitative and quantitative determination and the like.

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Номер записи: 8